CN109324174A - A kind of smart phone sperm analysis instrument that instant health is easy-to-use - Google Patents
A kind of smart phone sperm analysis instrument that instant health is easy-to-use Download PDFInfo
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- CN109324174A CN109324174A CN201810927986.5A CN201810927986A CN109324174A CN 109324174 A CN109324174 A CN 109324174A CN 201810927986 A CN201810927986 A CN 201810927986A CN 109324174 A CN109324174 A CN 109324174A
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Abstract
The invention discloses a kind of smart phone sperm analysis instrument that instant health is easy-to-use, are related to medical treatment detection device field.The present invention includes the smart phone for carrying ontology, sperm micro-fluidic chip, being connected on carrying ontology, carrying ontology includes the cell type shell of a 3D printing, there are four the buckles being engaged by clamping with the shell of smart phone for the upper surface setting of cell type shell, the one side of cell type shell offers a slot, and sperm micro-fluidic chip is slidably matched with slot.The present invention is by providing a kind of cell type shell with buckle and sperm micro-fluidic chip slot by 3D printing, LED luminescent system and battery are installed in cell type shell, the smart phone with the application program for recording and detecting semen quality data on cell type shell is matched with the sperm micro-fluidic chip being plugged in slot, sperm in sperm micro-fluidic chip is analyzed and detected, detection price holds high that cheap, detection speed is fast, operation is convenient, detection efficiency is high.
Description
Technical field
The invention belongs to medical treatment detection device fields, more particularly to a kind of smart phone that instant health is easy-to-use essence
Sub- analyzer.
Background technique
Infertile Mr. and Mrs of the whole world more than 45,000,000, wherein 40% or more case be male dominate it is infertile because
Element.Semen analysis is to detect the standard of male infertility infertility, but male usually from goes for urologist and feels awkward, female
Property at this time undertake more infertile censures.This is, economical, and culture, society, geographical, religion etc. is infertile detection
Major obstacle, worldwide, especially developing country, related disease are the health care problems underestimated and ignored
One of.The key criterion for judging sperm quality is sperm concentration, motion state and form, and Manual Microscope is tested and computer aided manufacturing
Helping sperm analysis (CASA) system is the main method of current clinical criteria, however, these methods are labour-intensive, prices
It is expensive and be based on laboratory.CASA technology needs well-trained people to operate simultaneously, could generate reliably and repeat
As a result.Due to the characteristic costly of system, many clinics and small hospital of giving birth to do not have the platform based on CASA, therefore
Semen analysis is carried out using the manual methods taken time and effort.Manual test is the result is that subjective, therefore different clinics are difficult to do
To consistent.
There are also other methods, such as turbidimetry, photon correlation spectroscopy, Laser Doppler speed for current sperm detection
Instrument, the analysis based on impedance, no lens imaging, the occlusion detection based on paper and the imaging based on concave-sphere.Then these methods
All each have their own problem, without really realizing that the requirement of quick diagnosis (Point of care) inexpensively quickly and easily uses,
And serve the user of no any semen analysis experience.Wherein this certain methods cannot directly assess sperm concentration and work
Power, but almost all of method requires valuableness, huge data collecting instruments and independent data processing apparatus.
Work in terms of the accurate analysis sperm of most recently used sphere lens-mobile phone setting progress, is only exaggerated shifting
Image on liquid to polyethylene print needs the monitor that worksheet is transmitted to Duan Du to be operated manually analysis.
Then expert technical staff can be with the activity of the sperm quantity of the every FOV of manual calculations and sample.The research report shows to use this
The mobile device of kind sphere lens can be easy to produce high-frequency wrong egative film.Therefore this sphere lens mobile phone setting is uncomfortable
Front yard semen analysis of the whole family.
With family, basic male infertility infertility detection method is not Fertimarq and Sperm currently on the market
Check, they are used to detect the sperm-specific protein of sperm head using chemical staining methods.
Trak, the product of another food and drug administration approval, using centrifuge for estimating microfluid
The power of sperm on decoration, the analysis need the commemorative analysis of a compact centrifuge and classify to sperm, and sample is based on essence
Sub- concentration standard not 15,000,000 sperms/ml, accuracy > 94%.But all these measurement intelligent measure sperm concentrations, without
It is the power of sperm.
Microfluid has had shown that the big advantage of tool as a kind of novel biotechnology, and regrowth doctor is widely applied
It learns in equipment, then medicine and biology, such as low-cost bio sensing analysis, single cell analysis, gene expression spectrum analysis and DNA
Sequence analysis.On sperm analysis, microfluid it is past be suitable attention to be also resulted in 10 years, and have several advanced point
Analysis platform has been developed, such as the sperm genomics of the high amount of spitting.On the other hand, the progress of consumption electronic product, it is special
It is not that mobile processing capacity improves, memory capacitance increases, and the development of power consumption and function is all application paving of the microfluid in health care
Road is put down.Current numerous medical applications are realized by increasing external accessory in mobile phone, such as are tied on the camera of mobile phone
That closes a variety of accurate diagnosis (point of care) sets change.Pass through compound a variety of micro-fluidic chips, pH effect chip, mobile phone
Very strong function is capable of providing to go to realize the cheap and easy-to-use infertile diagnostic function of mobile phone.
Here, a kind of smart phone sperm analysis instrument that instant health is easy-to-use is illustrated, by the way that on a small quantity new is added
Fresh sperm (< 35 microlitres) sample is encased in the disposable microfluidic device for measuring sperm concentration to test sperm concentration and fortune
Dynamic property is easy to use, quickly, high degree of automation and cheap.The concentration of its offer precision simultaneously, energy value, and
Linear viscosity and curve viscosity.Sperm is loaded into the disposable microfluidic device of low cost, is quickly divided by handset image
Analyse sample.Along a modular volume, sperm capacity can be amounted to, total sperm count and total motile count, solution
It has determined problem above.
Summary of the invention
The purpose of the present invention is to provide a kind of smart phone sperm analysis instrument that instant health is easy-to-use, pass through offer
A kind of cell type shell buckled with sperm micro-fluidic chip slot that has by 3D printing, is equipped with LED and shines in cell type shell
System and battery, on cell type shell with record and the smart phone of the application program of detection semen quality data be plugged in
Sperm micro-fluidic chip in slot matches, and the sperm in sperm micro-fluidic chip is analyzed and detected, and solves existing
Some sperms detect the problem of expensive detection slow, the inconvenient victory of speed.
In order to solve the above technical problems, the present invention is achieved by the following technical solutions:
The present invention is a kind of smart phone sperm analysis instrument that instant health is easy-to-use, including to carry ontology, sperm micro-
Fluidic chip, the smart phone being connected on carrying ontology, the carrying ontology includes the cell type shell of 3D printing, described
There are four the buckle being engaged by clamping with the shell of smart phone, the one sides of the cell type shell for the upper surface setting of cell type shell
A slot is offered, the inner top surface and inner bottom surface of the slot offer corresponding with the camera position of smart phone respectively
An aspherical microlens eyeglass, institute are fixedly installed in one through-hole and the second through-hole, the first through hole and the second through-hole respectively
Sperm micro-fluidic chip is stated to be slidably matched with slot；
The inner bottom surface of the cell type shell is fixedly installed with charged lithium cells and the white opposite with the second lead to the hole site
The another side of LED lamp, the cell type shell is provided with charging jack and switch button.
Further, the sperm micro-fluidic chip is the disposable micro fluidic device based on unpowered mechanical pumping sample,
Using polydimethylsiloxane light bulb, end is generating negative pressure chamber come made of load sample on slide.
Further, the load sample is not washing less than 35 microlitres, untreated sample of sperm.
Further, it is mounted with by way of taking pictures in the smart phone and records semen quality data in real time and store
The application program of these data, the application program is taken pictures with the speed of 30 frame per second and measurement and records print, described to apply journey
Sequence automatically generates imaging report and report result according to record print.
The invention has the following advantages:
The present invention is by providing a kind of cell type shell with buckle and sperm micro-fluidic chip slot by 3D printing, box
LED luminescent system and battery are installed, the application with record and detection semen quality data on cell type shell in shell body
The smart phone of program is matched with the sperm micro-fluidic chip being plugged in slot, to the sperm in sperm micro-fluidic chip into
Row analysis and detection have the advantages that sperm detection and analysis is cheap, detection speed is fast, operation is convenient.
Certainly, it implements any of the products of the present invention and does not necessarily require achieving all the advantages described above at the same time.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, will be described below to embodiment required
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for ability
For the those of ordinary skill of domain, without creative efforts, it can also be obtained according to these attached drawings other attached
Figure.
Fig. 1 is a kind of structural schematic diagram of the easy-to-use smart phone sperm analysis instrument of instant health of the invention；
State signal when Fig. 2 is a kind of instant health of the invention easy-to-use smart phone sperm analysis instrument work
Figure；
Fig. 3 is the schematic diagram of internal structure of carrying ontology of the invention；
Fig. 4 is the structure rearview of Fig. 3；
In attached drawing, parts list represented by the reference numerals are as follows:
1- carries ontology, 2- smart phone, 3- sperm micro-fluidic chip, 4- charged lithium cells, 5- switch button, 6- charging
Socket, 7- white light-emitting diode LED light, 11- cell type shell, 12- buckle, 13- slot, 14- first through hole, 15- second are logical
Hole, 21- camera.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts all other
Embodiment shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " upper surface ", "inner", " top surface ", " bottom surface ", " other side
The indicating positions such as face " or positional relationship, are merely for convenience of description of the present invention and simplification of the description, rather than indication or suggestion is signified
Component or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as to the present invention
Limitation.
It please referring to shown in Fig. 1-4, the present invention is a kind of smart phone sperm analysis instrument that instant health is easy-to-use, including
Carrying ontology 1, sperm micro-fluidic chip 3, the smart phone 2 being connected on carrying ontology 1, carrying ontology 1 include a 3D printing
Cell type shell 11, there are four the buckle 12 being engaged by clamping with the shell of smart phone 2, boxes for the upper surface setting of cell type shell 11
The one side of shell body 11 offers a slot 13, and the inner top surface and inner bottom surface of slot 13 offer and smart phone 2 respectively
It is fixed respectively in the corresponding first through hole 14 in 21 position of camera and the second through-hole 15, first through hole 14 and the second through-hole 15 to pacify
Equipped with an aspherical microlens eyeglass, sperm micro-fluidic chip 3 is slidably matched with slot 13；
The inner bottom surface of cell type shell 11 is fixedly installed with charged lithium cells 4 and the white opposite with 15 position of the second through-hole
LED lamp 7, the another side of cell type shell 11 are provided with charging jack 6 and switch button 5.
Wherein, sperm micro-fluidic chip 3 is to use poly- two based on the disposable micro fluidic device of unpowered mechanical pumping sample
Methyl-monosilane light bulb, end is generating negative pressure chamber come made of load sample on slide.
Wherein, load sample is 30 microlitres and does not wash, untreated sample of sperm.
Wherein, the length for carrying ontology 1 is respectively 15.2cm, 8.2cm, 3.4cm, and carrying 1 mass of ontology is 75g.
Wherein, it is mounted with by way of taking pictures in smart phone 2 and records semen quality data in real time and store these numbers
According to application program, application program taken pictures with the speed of 30 frame per second and measurement and records print, and application program is according to record print
Automatically generate imaging report and report result.
Wherein, the effective FOV of smart phone 2 is 886*886 pixel, is Motorola MotoX model smart phone, intelligence
Result averagely used time 4.48s in total is reported and reported to 2 automated imaging of mobile phone.
Wherein, total Mobile phone accessory cost and the price of disposable microfluidic device are 4.45 U.S. dollars, and wherein mobile phone optics is attached
Part cost is 3.59 dollars, and micro-fluidic cost is at 0.86 dollar.
Wherein, the training and execute what untrained user was obtained using CASA platform that the test of smart phone 2 obtains
Results, and it was found that the analyzer based on smart phone 2 can detecte the sperm concentration (< 1500 of abnormal conditions semen sample
Ten thousand sperms/ml) and motility (< 40%) between 0 to 4.08 hundred million sperms/milliliter, accuracy 97.71%.Based on intelligent hand
Agreement between the analyzer and CASA of machine 2 is analyzed using Passing-Bablok regression analysis and Bland-Altman, patient
The quantitative result of semen sample shows fabulous result.
The preclinical sample for detecting low sperm count:
When assessing the performance of the semen analysis instrument based on smart phone, sample point is carried out according to concentration gradient at low concentrations
Class measures the sperm concentration of 56 parts of freezing preservation seminal fluid samples in double blind experiment, this also sperm concentration substantially 100,000
A sperm/ml.In addition parallel laboratory test is that an independent technical staff is allowed to count manually under the microscope by standard cell counts device
Number sperm, this method have evaluated the system in the judge ability of lower sperm concentration, are especially used to monitor vasectoray
Patient.The patient for receiving vasectoray needs to assess his sperm in 3 to 6 months after surgery, be tested by detecting
Whether card operation is successful (sperm concentration ,≤100,000 sperm/ml).
Passing-Bablok regression analysis (n=56) shows that the values of intercept of A is 0.02078, and confidence interval (CI) is
0.06186 to 0.001318, B slope value are that 0.9530, CI is 0.7913 to 1.0032.
The accumulation, which is linearly tested to be displayed without, has apparent dominance deviation with P=0.52.
Bland-Altman analysis is compared flat based on smart phone counting and based on two kinds of sperm counts of Manual Microscope
Equal deviation is 0.07612 hundred million/milliliter, and standard deviation range is 4,270,000 sperm/ml, consistency boundary condition be 8.446 to
823.30 ten thousand sperm/ml.
These statistical analysis show that the deviation of two kinds of analysis means is increased by the increase of seminal concentration.However it is testing
In, the fixed concentration difference of two kinds of sperm test methods is not observed.By establishing an optimum sensitivity and specific threshold
Value analysis, establishes recipient's operating characteristic curve (ROC) and analyzes.The analysis chart of ROC and vertical scatter plot illustrate
The sensitivity and specificity of equipment.ROC (n=56) shows best when sperm concentration threshold value is 0.103*106 sperm/milliliter
Sensitivity is that 92.86%, CI value is 66.1% to 100%,.It is lower than 100,000 sperm/milliliter measurement threshold values in identification
It is accuracy rate 98.21%, area (AUC) is 0.9930 under the curve of areas, has the exact CI range of binomial from 0.9230
To 1.0000.
It is trained to test clinical semen sample using user:
The performance of the semen analysis instrument based on smart phone, sensitivity, specificity and accuracy are assessed, is come from by test
The semen sample of 164 parts of Massachusetts General Hospital (MGH), and result is compared with the CASA result obtained.Proof exists on the whole
Sperm concentration test and Sperm Motility test repeatable consistency 90% or more.It is returned and is divided using Passing-Bablok
Analysis method (n=164) analyzes two kinds of sperm systems of device and CASA based on smart phone, in patient's semen sample
In concentration map.A and B value is respectively 1.5762 (CI, 0.4678 to 2.8996) and 0.8801 (CI, 0.8106 to 0.9588).Line
Property angle point test with P=0.69 there is no significant deviation from linearity.These results indicate that based on smart phone sperm diagnosis system
System, in the measurement of high sperm concentration (> 1 hundred million sperms/ml), there are this saturation points.However the saturation point of device is not appointed
What meaning, will not influence the performance of sperm diagnostic analysis.By being evaluated in 15,000,000 sperms that WHO assert/ml threshold point
Sperm concentration, analyzer diagnostic accuracy and characteristic based on smart phone 2 have respectively reached 91.30% (CI, 79.21 arrive
97.58%) and 97.46 (CI, 92.75 to 99.47%), corresponding accuracy rate are that 95.73%. is gone based on mobile phone detection device
Monitor sperm.
In the description of this specification, the description of reference term " one embodiment ", " example ", " specific example " etc. means
Particular features, structures, materials, or characteristics described in conjunction with this embodiment or example are contained at least one implementation of the invention
In example or example.In the present specification, schematic expression of the above terms may not refer to the same embodiment or example.
Moreover, particular features, structures, materials, or characteristics described can be in any one or more of the embodiments or examples to close
Suitable mode combines.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to better explain the present invention
Principle and practical application, so that skilled artisan be enable to better understand and utilize the present invention.The present invention is only
It is limited by claims and its full scope and equivalent.
Claims (4)
1. a kind of smart phone sperm analysis instrument that instant health is easy-to-use, which is characterized in that including carrying ontology (1), essence
Liquid micro-fluidic chip (3), the smart phone (2) being connected in carrying ontology (1), the carrying ontology (1) include a 3D printing
Cell type shell (11), there are four be engaged by clamping with the shell of smart phone (2) for the upper surface setting of the cell type shell (11)
Buckle (12), the one side of the cell type shell (11) offers a slot (13), the inner top surface of the slot (13) and interior
Bottom surface offers first through hole (14) corresponding with camera (21) position of smart phone (2) and the second through-hole (15) respectively,
An aspherical microlens eyeglass, the sperm miniflow are fixedly installed in the first through hole (14) and the second through-hole (15) respectively
Control chip (3) is slidably matched with slot (13)；
The inner bottom surface of the cell type shell (11) is fixedly installed with charged lithium cells (4) and opposite with the second through-hole (15) position
White light-emitting diode LED light (7), the another side of the cell type shell (11) is provided with charging jack (6) and switch is pressed
Button (5).
2. a kind of smart phone sperm analysis instrument that instant health is easy-to-use according to claim 1, which is characterized in that institute
Stating sperm micro-fluidic chip (3) is to use polydimethylsiloxane based on the disposable micro fluidic device of unpowered mechanical pumping sample
Light bulb, end is generating negative pressure chamber come made of load sample on slide.
3. a kind of smart phone sperm analysis instrument that instant health is easy-to-use according to claim 2, which is characterized in that institute
Stating load sample is not washing less than 35 microlitres, untreated sample of sperm.
4. the easy-to-use smart phone sperm analysis instrument of an instant health according to claim 1, which is characterized in that institute
It states smart phone (2) and is mounted with the application journey for recording semen quality data in real time by way of taking pictures and storing these data
Sequence, the application program are taken pictures with the speed of 30 frame per second and measurement and record print, the application program according to record print from
It is dynamic to generate imaging report and report result.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111551544A (en) * | 2020-05-06 | 2020-08-18 | 东南大学 | Bivalent copper ion rapid detection device and detection method based on paper-based micro-fluidic chip |
| CN112673090A (en) * | 2018-10-29 | 2021-04-16 | Nok株式会社 | Micro-fluidic chip and micro-fluidic device |
| CN113884453A (en) * | 2021-09-30 | 2022-01-04 | 太原理工大学 | Detection device based on smartphone immunoturbidimetry and application of detection device in rapid detection of myocardial infarction marker |
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Application publication date: 20190212 |