CN109320510A - Preparation method of Maropitan free base - Google Patents
Preparation method of Maropitan free base Download PDFInfo
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- CN109320510A CN109320510A CN201811427521.XA CN201811427521A CN109320510A CN 109320510 A CN109320510 A CN 109320510A CN 201811427521 A CN201811427521 A CN 201811427521A CN 109320510 A CN109320510 A CN 109320510A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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Abstract
The invention relates to a preparation method of free maririptan alkali, and the reaction relates to (2S,3R) -2-benzhydrylquinuclidine-3-alcohol and R1SO2Cl or (CF)3SO2)2And reacting the compound IV with 2-methoxy-5-tert-butyl-benzylamine in the presence of alkali and a solvent to obtain free maripidan alkali.
Description
Technical field
The invention belongs to synthesis material prescription law technology fields, and in particular to the preparation of the smooth free alkali of bulk pharmaceutical chemicals horse sieve.
Background technique
Citric acid horse sieve smooth (Maropitant Citrate) is the receptor anticaking agent of 1 type neurokinin (NK1), can be led to
It crosses inhibition P substance (nauseant key neurotransmitter) and acts on central nervous system.Citric acid horse sieve is smooth to be belonged to
One kind of the peaceful drug of alternative quinoline, due to significant in efficacy, FDA in 2007 ratifies the medicine and vomits for preventing and treating the acute of dog
It spits, the subsequent prescription externally applied drug for being equally approved for cat.Citric acid horse sieve is smooth, and there are two types of dosage form, the citric acid horses of injection
The smooth acute vomiting for being applied to prevent and treat dog of sieve；Tablet citric acid horse sieve is smooth for the acute of preventing canine and due to dizzy
Vomiting caused by dynamic disease；It both can be used as the prescription externally applied drug of cat.The Ministry of Agriculture has approved citric acid horse sieve in May, 2016
Smooth import registration is equally used for preventing and treating the acute vomiting of dog.
Citric acid horse sieve is smooth to be also known as CJ-11,972, trade name Cerenia (antiemetic is peaceful), by Pfizer's original
Grind exploitation.The smooth molecular weight of citric acid horse sieve is 678.82, and chemical name is (2S, 3S) -2- benzhydryl-N- (tertiary fourth of 5-
Base -2- methoxy-benzyl) the peaceful citrate monohydrate of -3- amino-quinoline.Its chemical structural formula is as follows:
Document WO2004035575, WO2005075473 etc. are open to report the smooth synthetic method of horse sieve；This method
Synthetic route needs 8 step reactions to realize the preparation of the smooth free alkali of horse sieve, is directed to uncontrollable phenyl-magnesium-bromide
Grignard reagent and cuprous bromide dimethyl sulphide (CuBr (CH3)2S) the Michael addition reaction of participation, multi-step pressure hydration
Reaction etc..Specific reaction equation is as follows:
Not only route is long for the method for the above-mentioned smooth free alkali of synthesis horse sieve, and yield is low, and (8 step overall yield of reaction are only 10%
Left and right), and be related in reaction process using a variety of precious metals, such as Ti, Pt, Pd, it is not only at high cost, and remove these
Noble metal residual needs to expend a large amount of solvent and adsorbent.For this purpose, developing the smooth method of new synthesis horse sieve to this
The industrialization production of drug is even more important.
Summary of the invention
The purpose of the present invention is to provide a kind of new methods for preparing the smooth free alkali of horse sieve, it is intended to original be avoided to grind in patent
It is a large amount of using noble metal reagent, chiral split reagent and the low defect of total recovery.
Synthetic route of the invention is as follows:
The reaction first step is related to (S) -2- benzhydryl-quinuclidine -3- ketone (Formulas I) in Na/i-PrOH/Toluene condition
Lower reaction generates (2S, 3R) -2- benzhydryl-quinuclidine -3- alcohol (Formula II).
Reaction second step be by Formula II compound in the presence of alkali and solvent and R1SO2Cl or (CF3SO2)2O reacts
Obtain the compound formula IV of hydroxyl protection.
The solvent that reaction second step uses is CH2Cl2,THF,2-MeTHF,Dioxane,CH3CN。
The alkali that reaction second step uses is Pyridine, Et3N,DIPEA,Morpholine,DMAP。
The R of formula III1For methyl, p-methylphenyl, phenyl.
The R of formula IV2For mesyl (Ms), p-toluenesulfonyl (Ts), trifyl (Tf), benzenesulfonyl
(PhSO2-)。
Reaction third step is sent out in the presence of alkali and solvent with 2- methoxyl group -5- tert-butyl-benzylamine by formula IV compound
Raw reaction obtains the smooth free alkali of horse sieve.
Reacting alkali used in third step is Et3N,DIPEA,Pyridine,Morpholine,DMAP。
Reacting solvent used in third step is THF, 2-MeTHF, DMF, CH2Cl2, Dioxane, CH3CN, TMBE.
Synthetic route of the invention is short, and total recovery is high, and the reagent used is easy to be commercialized a large amount of buyings, technological operation letter
It is single, and be not related to being suitble to the industrial amplification production of the smooth free alkali of horse sieve using noble metals such as Pd, Ti, Pt.
Specific embodiment
Following exemplary embodiments are used to illustrate that the present invention, technical staff in the art are simply replaced to what the present invention was done
It changes and improves etc. and belong within the technical solution that the present invention is protected.
Embodiment one: the preparation of (2S, 3R) -2- benzhydryl-quinuclidine -3- alcohol (Formula II)
(S) -2- benzhydryl-quinuclidine -3- ketone (Formulas I) (130g, 446mmol, 1.0eq.) and first are added in 5L reaction flask
Benzene (1.8L), system is heated to reflux a point water after addition, removes water a small amount of in reaction system.Then system reflux state
Under be slowly added to the metal Na (50g, 2175mmol) being cut into small pieces, be slowly added to i-PrOH under reflux state after addition
(450mL).System back flow reaction is naturally cooling to room temperature after 1.5 hours, methanol (1L) quenching reaction is added in reaction system.System
Removal solvent is concentrated under reduced pressure in high vacuum, and H is added in residue2O (2L) and CH2Cl2(1L), system stand after stirring 3 hours, separate
Organic phase, water phase CH2Cl2(3 × 500mL) is extracted three times, merges organic phase, and removal solvent is concentrated under reduced pressure in organic phase high vacuum,
Residue column chromatographic purifying obtain (2S, 3R) -2- benzhydryl-quinuclidine -3- alcohol (Formula II) (light yellow solid, 94.3g,
72.1%).
Embodiment two: (2S, 3R) -2- benzhydryl -3- mesyloxy-quinine (formula IV, R2=Ms) preparation
(2S, 3R) -2- benzhydryl-quinuclidine -3- alcohol (Formula II) (5.0g, 17mmol) and CH are added into reaction flask2Cl2
(15mL).Reaction system ice salt bath is cooled to 5 DEG C, then slow transits through dropping funel and Pyridine (25mL) and MsCl is added
(4.0g, 34.9mmol).System warms naturally to after being stirred at room temperature 5 hours after addition, and system is heated to back flow reaction 2
Hour, then system is naturally cooling to room temperature.HCl solution (2N in H is added in system2O) regulation system pH value is to 8-9, then
CHCl is added3(3 × 120mL) is extracted three times, merges organic phase, and removal solvent, residue column is concentrated under reduced pressure in organic phase high vacuum
Chromatographic purifying obtains (2S, 3R) -2- benzhydryl -3- mesyloxy-quinine (formula IV, R2=Ms) (5.15g, 81.5%).
Embodiment three: the preparation of the smooth free alkali of horse sieve
(2S, 3R) -2- benzhydryl -3- mesyloxy-quinine (formula IV, R is added in reaction flask2=Ms) (4.5g,
12.11mol) and DMF (20mL).After addition, into system be added triethylamine (4.9g, 48.42mmol, 4.0eq.) and
2- methoxyl group -5- tert-butyl-benzylamine (3.50g, 18.11mol).System is warming up to 100 DEG C of reactions to TLC tracking after addition
Disappearance of starting material.System is naturally cooling to room temperature, system high vacuum removed under reduced pressure organic solvent, and CH is added in residue2Cl2
(60mL) and H2O (60mL) separates organic phase, water phase CH2Cl2It extracts (3 × 30mL).Merge organic phase, organic phase saturation
Brine It (50mL), anhydrous Na2SO4Precipitation is depressurized after drying, residue column chromatographic purifying obtains the smooth free alkali of horse sieve
(4.94g, 87.1%).
Example IV: (2S, 3R) -2- benzhydryl -3- trifluoro-methanesulfonyl oxy-quinine (formula IV, R2=Tf) preparation
(2S, 3R) -2- benzhydryl-quinuclidine -3- alcohol (Formula II) (12.2g, 41.6mmol) and nothing are added into reaction flask
Water THF (40mL).Reaction system ice salt bath is cooled to 5 DEG C or so, then slow transits through dropping funel and DIPEA (50mL) is added
And Tf2O(23.5g,83.3mmol).System warms naturally to be stirred at room temperature 24 hours after addition.It is molten that HCl is added in system
Liquid (2N in H2O) then CHCl is added to 8-9 in regulation system pH value3(3 × 200mL) is extracted three times, merges organic phase, organic
Removal solvent is concentrated under reduced pressure in phase high vacuum, and residue column chromatographic purifying obtains (2S, 3R) -2- benzhydryl -3- trifluoro methylsulfonyl
Oxygroup-quinine (formula IV, R2=Tf) (13.48g, 76.2%).
Embodiment five: the preparation of the smooth free alkali of horse sieve
(2S, 3R) -2- benzhydryl -3- trifluoro-methanesulfonyl oxy-quinine (formula IV, R is added in reaction flask2=Tf)
(12.0g, 28.2mol) and 2-MeTHF (50mL).After addition, DMAP (10.34g, 84.64mmol) is added into system
With 2- methoxyl group -5- tert-butyl-benzylamine (6.55g, 33.89mol).After addition system be warming up to back flow reaction to TLC with
Track disappearance of starting material.System is naturally cooling to room temperature, system high vacuum removed under reduced pressure organic solvent, and CH is added in residue2Cl2
(120mL) and H2O (120mL) separates organic phase, water phase CH2Cl2It extracts (3 × 60mL).Merge organic phase, organic phase saturation food
Salt water washing (120mL), anhydrous Na2SO4Precipitation is depressurized after drying, residue column chromatographic purifying obtains the smooth free alkali of horse sieve
(10.92g, 82.6%).
Claims (6)
1. the method for preparing the smooth free alkali of horse sieve, reaction equation are as follows:
2. the preparation method with compound formula IV as shown in claim 1, it is characterised in that Formula II compound is in alkali and molten
In the presence of agent and R1SO2Cl or (CF3SO2)2O reacts to obtain the compound formula IV of hydroxyl protection.
3. in claim 2, reacting the solvent used is CH2Cl2,THF,2-MeTHF,Dioxane,CH3CN；What reaction used
Alkali is Pyridine, Et3N,DIPEA,Morpholine,DMAP。
4. in claim 2, the R of formula III1For methyl, p-methylphenyl, phenyl；The R of formula IV2For mesyl (Ms), to first
Benzenesulfonyl (Ts), trifyl (Tf), benzenesulfonyl (PhSO2-)。
5. the preparation method with the smooth free alkali of horse sieve as shown in claim 1, it is characterised in that exist in alkali and solvent
Following formula I V and 2- methoxyl group -5- tert-butyl-benzylamine reacts to obtain the smooth free alkali of horse sieve.
6. in claim 5, reacting the alkali used is Et3N,DIPEA,Pyridine,Morpholine,DMAP；Reaction is used
Solvent be THF, 2-MeTHF, DMF, CH2Cl2, Dioxane, CH3CN, TMBE.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110713488A (en) * | 2019-11-28 | 2020-01-21 | 海门慧聚药业有限公司 | Crystal form of Maropiptan free base and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3560510A (en) * | 1969-03-05 | 1971-02-02 | Aldrich Chem Co Inc | 2-benzhydrylquinuclidines |
| WO2002085901A1 (en) * | 2001-04-19 | 2002-10-31 | Pharmacia & Upjohn Company | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
| CN1914202A (en) * | 2004-02-02 | 2007-02-14 | 辉瑞产品有限公司 | Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine |
| US20110144150A1 (en) * | 2009-12-14 | 2011-06-16 | Lampe John W | Bridged bicyclic rho kinase inhibitor compounds, composition and use |
| CN106977512A (en) * | 2017-05-04 | 2017-07-25 | 海门慧聚药业有限公司 | The method for preparing the smooth free alkali of horse sieve |
-
2018
- 2018-11-27 CN CN201811427521.XA patent/CN109320510B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3560510A (en) * | 1969-03-05 | 1971-02-02 | Aldrich Chem Co Inc | 2-benzhydrylquinuclidines |
| WO2002085901A1 (en) * | 2001-04-19 | 2002-10-31 | Pharmacia & Upjohn Company | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
| CN1914202A (en) * | 2004-02-02 | 2007-02-14 | 辉瑞产品有限公司 | Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine |
| US20110144150A1 (en) * | 2009-12-14 | 2011-06-16 | Lampe John W | Bridged bicyclic rho kinase inhibitor compounds, composition and use |
| CN106977512A (en) * | 2017-05-04 | 2017-07-25 | 海门慧聚药业有限公司 | The method for preparing the smooth free alkali of horse sieve |
Non-Patent Citations (2)
| Title |
|---|
| KOMAL G. LALWANI ET AL.: "《A Concise Enantioselective Synthesis of (+)-L-733,060 and (+)-T-2328 via Sequential Proline Catalysis》", 《SYN LETT》 * |
| ZUNHUA YANG ET AL.: "《Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist》", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110713488A (en) * | 2019-11-28 | 2020-01-21 | 海门慧聚药业有限公司 | Crystal form of Maropiptan free base and preparation method thereof |
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Address after: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Applicant after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Address before: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Applicant before: WISDOM PHARMACEUTICAL Co.,Ltd. |
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Address after: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Patentee after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Address before: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Patentee before: Jiangsu Huiju Pharmaceutical Co.,Ltd. |