CN109304094A - A kind of active electric diacolation takes the integrating device and its extraction integrated approach of microring array - Google Patents
A kind of active electric diacolation takes the integrating device and its extraction integrated approach of microring array Download PDFInfo
- Publication number
- CN109304094A CN109304094A CN201811445823.XA CN201811445823A CN109304094A CN 109304094 A CN109304094 A CN 109304094A CN 201811445823 A CN201811445823 A CN 201811445823A CN 109304094 A CN109304094 A CN 109304094A
- Authority
- CN
- China
- Prior art keywords
- liquid
- fluid passage
- liquid inlet
- phase
- diacolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000605 extraction Methods 0.000 title claims abstract description 34
- 239000007788 liquid Substances 0.000 claims abstract description 193
- 239000012530 fluid Substances 0.000 claims abstract description 115
- 239000011521 glass Substances 0.000 claims abstract description 12
- 239000000758 substrate Substances 0.000 claims abstract description 12
- 238000000622 liquid--liquid extraction Methods 0.000 claims abstract description 9
- 238000000638 solvent extraction Methods 0.000 claims abstract description 9
- 239000012071 phase Substances 0.000 claims description 43
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 14
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 14
- 239000012074 organic phase Substances 0.000 claims description 12
- 239000008346 aqueous phase Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 9
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 230000005684 electric field Effects 0.000 description 4
- 238000005370 electroosmosis Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000005501 phase interface Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 230000036632 reaction speed Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
Abstract
The invention discloses integrating devices and its extraction integrated approach that a kind of active electric diacolation takes microring array, belong to microfluidic art.Including glass substrate, liquid inlet I, the components such as liquid inlet II, chip is arranged on a glass substrate, liquid inlet I, liquid inlet II is connected with one end of fluid passage I, the other end of fluid passage I and liquid inlet III, liquid inlet IV is connected to after crossing with one end of fluid passage II, the other end of fluid passage II is separately connected liquid outlet I, liquid outlet II, the fluid passage I and II outside wall surface two sides of fluid passage are alternately equipped with laterally disposed electrode block, one piece or more the cuboid floor vertically placed is equipped with inside the fluid passage I and fluid passage II.The present invention can be such that two-phase liquid is sufficiently mixed, so that improving liquid-liquid extraction efficiency controllably realizes liquid drop movement, internal mix and reaction, effectively provide the extraction efficiency of microchip.
Description
Technical field
The present invention relates to integrating devices and its extraction integrated approach that a kind of active electric diacolation takes microring array, belong to miniflow
Control technical field.
Background technique
Micro-fluidic chip is to form network by microchannel, and it is tens of to hundreds of microns that reaction compartment, which is limited in size range,
Channel interior, controlled fluid runs through whole system, and by laboratories such as biology, chemistry, miniature to one piece of basic function several to be put down
On square centimetre of chip, a variety of biologies, chemical analysis processes may be implemented.Reaction system has high under the microreactor scale
Specific surface area and high mass-transfer performance not only can significantly shorten the reaction time by accurate process control and reduce sample
Product consumption, it is often more important that the increase that quantity is directly carried out using microreactor as basic unit can realize the integrated of module, into
And realize high-throughput product controllable preparation, it is expected non-so as to avoid being difficult to caused by the direct geometry amplification of traditional reactor
Ideal behavior.Microfluidic device is widely used in the fields such as integrated electronic, precision instrument, Medical Devices and bio-pharmaceuticals, microfluid
Device is suitble to the exploitation of various flow control systems, and control technology includes light, electricity, gas, magnetic, heat, gas phase variation etc., micro-
It has been widely used in fluidic chip technology, if microfluid conveys, DNA sequence, cell separation etc..
Aqueous phase solution and extraction agent two-phase continue to flow through fluid passage in the prior art, are passed by the diffusion between two-phase
Matter effect carries out conventional extraction, and the extraction efficiency of the extraction is low, reaction speed is slow.
Summary of the invention
The technical problem to be solved in the present invention is to provide integrating devices and its extraction that a kind of active electric diacolation takes microring array
Integrated approach is taken, for solving the problems, such as that existing multi-phase fluid extraction efficiency is low, reaction speed is slow.The present invention uses PDMS material
Material production microchannel structure, can be restored to original state under certain deformation condition and structure there is no permanently breaking
It is bad.Microchannel structure is made using PDMS material, original state can be restored under certain deformation condition and structure does not have
There is generation permanent damage.The present invention, which collects laminar flow extraction and drop formation reaction, important application value, so as to efficient
Improve liquid-liquid extraction efficiency.
The technical solution adopted by the present invention is that: a kind of active electric diacolation takes the integrating device of microring array, including 1- glass
Substrate, the liquid inlet 2- I, the liquid inlet 3- II, 4- electrode block, 5- chip, the liquid inlet 6- III, 7- fluid passage II, 8- liquid
Body exports I, 9- liquid outlet II, the liquid inlet 10- IV, 11- fluid passage I, 12- cuboid floor；
The chip 5 is arranged in glass substrate 1, and the chip 5 is equipped with liquid inlet I 2, liquid inlet II 3, liquid inlet
III 6, liquid inlet IV 10, fluid passage I 11, fluid passage II 7, liquid outlet I 8, liquid outlet II 9；Liquid inlet I 2, liquid
Body entrance II 3 is connected with one end of fluid passage I 11, the other end of fluid passage I 11 and liquid inlet III 6, liquid inlet
IV 10 cross after be connected to one end of fluid passage II 7, the other end of fluid passage II 7 is separately connected liquid outlet I 8, liquid
II 9 are exported, fluid passage I 11 and fluid passage II 7 are in same level, the fluid passage I 11 and fluid passage II 7
Outside wall surface two sides are alternately equipped with laterally disposed electrode block 4, and the electrode of phase the same side electrode plate 4 is identical, different lateral electrode plates 4
Electrode on the contrary, the fluid passage I 11 and II 7 inside of fluid passage are equipped with one piece or more the cuboid rib vertically placed
Plate 12.
Preferably, every piece of 4 front end of electrode block is equipped with one piece of cuboid in the fluid passage I 11 and fluid passage II 7
Floor 12.
Preferably, the chip 5 is made of PDMS polydimethyl siloxane material.
Preferably, the feed liquor direction of the liquid inlet III 6 and liquid inlet IV 10 and fluid passage I 11 and fluid passage
II 7 is vertical.
Preferably, the chip 5 is 45mm long, wide 15mm, thick 5mm；The glass substrate 1 is 60mm long, wide 25mm, thick 5mm.
Preferably, the liquid inlet I 2, liquid inlet II 3, liquid inlet III 6, liquid inlet IV 10, liquid outlet I
8, the diameter of liquid outlet II 9 is 1mm, II 7 width d of fluid passage I 11 and fluid passage2For 0.5mm, high h2It is long for 0.35mm
The wide d of cube shape floor 121For 0.2mm, long L1For 0.1mm, height h2For 0.35mm, every electrode plate 4 is L long2It is wide for 0.7mm
Spend d3For 0.15mm, height h1For 0.2mm.
A method of taking the integrating device of microring array using a kind of active electric diacolation, to carry out extraction integrated, specifically
Step are as follows: first aqueous phase liquid is injected to liquid inlet I 2, to water phase liquid filled pipe I 11 and fluid passage II 7 and from liquid
After exporting the outflow of I 8, liquid outlet II 9, then aqueous phase liquid is injected from liquid inlet I 2 simultaneously, is injected from liquid inlet II 3 organic
Phase liquid, organic phase and water phase two-phase liquid enter jointly in fluid pipeline I 11, realize the extraction between water phase and oily phase, liquid
Body channel I 11 is externally provided with one piece or more of electrode plate 4, and cuboid corresponding with electrode plate 4 is additionally provided in fluid passage I 11
Shape floor 12 makes two-phase liquid carry out hybrid extraction by electrode plate 4 and cuboid floor 12 to the flow-disturbing of two-phase liquid,
Effect of extracting is improved, when two-phase liquid flows into fluid pipeline I 11 and fluid passage II 7, liquid inlet III 6, liquid inlet IV 10
Behind the cross channel formed, liquid inlet III 6, liquid inlet IV 10 are passed through in organic phase liquid to fluid passage II 7, into
Row multitple extraction realizes that organic phase package aqueous phase liquid carries out liquid-liquid extraction, and liquid flows into fluid passage II 7, fluid passage
II 7 outsides are equipped with electrode plate 4, inside is equipped with cuboid floor 12, carry out flow-disturbing again, it is to be extracted after final liquid from
It is flowed out in liquid outlet I 8, liquid outlet II 9.
The beneficial effects of the present invention are:
(1) electroosmotic flow mainly drives fluid by applying voltage, and present invention application exchanges driven by electroosmosis, and voltage is low, fast
Degree is fast, and electric osmose speed is proportional to alternating voltage square value.Usually very low voltage can be obtained the electric osmose similar with direct current electric osmose
Speed, so as to avoid the generation of electrochemical reaction and bubble and the appearance of joule heat problem.And the speed of electroosmotic flow may be used also
It is controlled with same voltage, the direction of fluid motion is controlled with the variation of voltage direction, control fluid difference position in micro-fluidic system
The flow set.
(2) present invention makes two-phase successively pass through two using the driving of passive type floor supplementary structure and alternating current field force
Person's liquid plays the role of very strong flow-disturbing, efficiently improves two-phase liquid extraction efficiency, increases the efficiency of two-phase liquid extraction.
(3) present invention efficiently improves two-phase liquid extraction efficiency, is changed to cross have by traditional two-phase extraction entrance
Machine mutually wraps up aqueous phase liquid, so that the contact area for increasing two-phase liquid improves the efficiency of laminar flow liquid-liquid extraction, shortens
Extraction time.
(4) present invention makes chip using PDMS polydimethyl siloxane material, and material translucency is good, biocompatibility is good
And good chemical inertness, the toughness of material is relatively high, and elasticity is good.
(5) apparatus of the present invention are mainly played very using electric field power drive and passive type floor supplementary structure using simply
Strong flow-disturbing effect, because its without mechanical moving element, at low cost and fluid motion is high-efficient the advantages that, be a kind of extensive use
Polymer material in micro-fluidic equal fields.
Detailed description of the invention
Fig. 1 is the chip overall structure diagram of apparatus of the present invention；
Fig. 2 is the enlarged drawing of fluid passage internal structure；
Fig. 3 is cross-sectional view of the Fig. 2 along line A-A.
Each label in figure are as follows: 1- glass substrate, the liquid inlet 2- I, the liquid inlet 3- II, 4- electrode plate, 5- chip, 6- liquid
Body entrance III, 7- fluid passage II, 8- liquid outlet I, 9- liquid outlet II, the liquid inlet 10- IV, 11- fluid passage I, 12-
Cuboid floor.
Specific embodiment
In the following with reference to the drawings and specific embodiments, the invention will be further described.
Embodiment 1: as shown in Figure 1-3, a kind of active electric diacolation takes the integrating device of microring array, including glass substrate 1,
Liquid inlet I 2, liquid inlet II 3, electrode block 4, chip 5, liquid inlet III 6, fluid passage II 7, liquid outlet I 8, liquid
Export II 9, liquid inlet IV 10, fluid passage I 11, cuboid floor 12；
The chip 5 is arranged in glass substrate 1, and the chip 5 is equipped with liquid inlet I 2, liquid inlet II 3, liquid inlet
III 6, liquid inlet IV 10, fluid passage I 11, fluid passage II 7, liquid outlet I 8, liquid outlet II 9；Liquid inlet I 2, liquid
Body entrance II 3 is connected with one end of fluid passage I 11, the other end of fluid passage I 11 and liquid inlet III 6, liquid inlet
IV 10 cross after be connected to one end of fluid passage II 7, the other end of fluid passage II 7 is separately connected liquid outlet I 8, liquid
II 9 are exported, fluid passage I 11 and fluid passage II 7 are in same level, the fluid passage I 11 and fluid passage II 7
Outside wall surface two sides are alternately equipped with laterally disposed electrode block 4, and the electrode of phase the same side electrode plate 4 is identical, different lateral electrode plates 4
Electrode on the contrary, the fluid passage I 11 and II 7 inside of fluid passage are equipped with one piece or more the cuboid rib vertically placed
Plate 12.
Further, every piece of 4 front end of electrode block is equipped with one piece of cuboid in the fluid passage I 11 and fluid passage II 7
Shape floor 12.
Further, the chip 5 is made of PDMS polydimethyl siloxane material.Due to entire chip 5 be by
What PDMS (dimethyl silicone polymer) material was constituted, material translucency is good, convenient for observing the flow behavior of fluid, biology when experiment
Compatibility is good and good chemical inertness, and the toughness of material is relatively high, and elasticity is good, and durability and resistance to pressure are relatively high.The dress
It sets and uses simply, it is at low cost, it is a kind of polymer material for being widely used in micro-fluidic equal fields.
Further, the feed liquor direction of the liquid inlet III 6 and liquid inlet IV 10 and fluid passage I 11 and liquid are logical
Road II 7 is vertical.
Further, the chip 5 is 45mm long, wide 15mm, thick 5mm；The glass substrate 1 is 60mm long, wide 25mm, thick
5mm。
Further, the liquid inlet I 2, liquid inlet II 3, liquid inlet III 6, liquid inlet IV 10, liquid outlet
I 8, the diameter of liquid outlet II 9 is 1mm, II 7 width d of fluid passage I 11 and fluid passage2For 0.5mm, high h2For 0.35mm,
The wide d of cuboid floor 121For 0.2mm, long L1For 0.1mm, height h2For 0.35mm, every electrode plate 4 is L long2For 0.7mm,
Width d3For 0.15mm, height h1For 0.2mm.
A method of taking the integrating device of microring array using a kind of active electric diacolation, to carry out extraction integrated, specifically
Step are as follows: first aqueous phase liquid is injected to liquid inlet I 2, to water phase liquid filled pipe I 11 and fluid passage II 7 and from liquid
After exporting the outflow of I 8, liquid outlet II 9, then aqueous phase liquid is injected from liquid inlet I 2 simultaneously, is injected from liquid inlet II 3 organic
Phase liquid, organic phase and water phase two-phase liquid enter jointly in fluid pipeline I 11, realize the extraction between water phase and oily phase, liquid
Body channel I 11 is externally provided with one piece or more of electrode plate 4, and cuboid corresponding with electrode plate 4 is additionally provided in fluid passage I 11
Shape floor 12 makes two-phase liquid carry out hybrid extraction by electrode plate 4 and cuboid floor 12 to the flow-disturbing of two-phase liquid,
Effect of extracting is improved, when two-phase liquid flows into fluid pipeline I 11 and fluid passage II 7, liquid inlet III 6, liquid inlet IV 10
Behind the cross channel formed, liquid inlet III 6, liquid inlet IV 10 are passed through in organic phase liquid to fluid passage II 7, into
Row multitple extraction realizes that organic phase package aqueous phase liquid carries out liquid-liquid extraction, and liquid flows into fluid passage II 7, fluid passage
II 7 outsides are equipped with electrode plate 4, inside is equipped with cuboid floor 12, carry out flow-disturbing again, it is to be extracted after final liquid from
It is flowed out in liquid outlet I 8, liquid outlet II 9.
Mixing duct inside fluid present invention pipeline I 11 and fluid passage II 7 inside from input duct to liquid outlet
The extraction efficiency that the device is improved using the asymmetric cuboid floor 12 in two sides, in the liquid flow after each supplementary structure
Cross-sectional area out halves, and flow velocity increases, and vortex and disturbance are produced in a small distance, so that stable laminar flow occurs
Biggish disturbance, disturbance is so that diffusion process of the target molecule from high concentration to low concentration is accelerated in water phase and organic phase.Cause
This, cuboid floor 12 not only promotes molecular motion of the target molecule in the vertical direction in each liquid phase, but also enhances
The transmittance process of target molecule at phase interface, to improve the extraction efficiency of liquid-liquid extraction significantly.
Fluid present invention pipeline I 11 and the outer two sides of fluid passage II 7 are equipped with electrode plate corresponding with cuboid floor 12
4, liquid, which often flows through, in fluid pipeline I 11 with fluid passage II 7 corresponds to the other side after a cuboid floor 12 and is equipped with
One electrode plate 4, electrode plate 4 are vertical with applying one on the outside of II 7 solid wall surface of fluid passage (dielectric) in fluid pipeline I 11
Electric field, since dielectric is non-conductive, vertical electrode is not to act directly on the solution of microchannel, the vertical electric field in outside
Can change the potential on the inside of wall surface by polarization, chip 5 of the present invention uses PDMS polydimethyl siloxane material, with
When two-phase liquid contacts, the surface of solids occurs hydrolysis and is polarized, and forms silanol surface groups, these groups may be positively charged,
Negative electricity or neutrality, counter ions in wall surface charge attraction solution related with the pH value of two-phase liquid repel same sex ion.It applies
It is powered under field action, fluid pipeline I 11 is distorted with liquid flow direction in fluid passage II 7, and the liquid near electrode plate 4
Region produces a local turbulence, so that irregularity is presented in flowing, so as to change initial distribution inside laminar flow, enhance
The transmittance process of target molecule at phase interface makes to wrap up mutually between them, effectively improves fluid pipeline I 11 and liquid
The mixing in channel II 7, to improve the extraction efficiency of liquid-liquid extraction significantly.
Fluid present invention pipeline I 11 and fluid passage II 7, liquid inlet III 6, liquid inlet IV 10 are formed cross logical
Realize that multitple extraction wraps up mutually in road, after three channels merge, liquid travels from liquid channel II 7, mixing liquid can go out again
Existing laminar condition, also be provided on fluid pipeline II 7 with the floor supplementary structure of fluid pipeline I 11 and electrode plate 4, finally take
II 9 two liquid outlet I 8, liquid outlet branch outlets collect mixing liquid.
The present invention makes microchannel structure using PDMS material, and original shape can be restored under certain deformation condition
There is no permanent damages for state and structure, and the present invention collects drop formation, drop is collected in one, passes through the pipe to two-phase liquid
Road setting and peripheral hardware electric field, can be such that two-phase liquid is sufficiently mixed, so that improving liquid-liquid extraction efficiency controllably realizes liquid
Drop movement, internal mix and reaction, while the specific surface area at extraction interface is increased, effectively provide the extraction effect of microchip
Rate, high reliablity, model simplification, it is readily appreciated that, it is simple to operate.
Specific embodiments of the present invention are explained in detail above in conjunction with attached drawing, but the present invention is not limited to above-mentioned realities
Example is applied, it within the knowledge of a person skilled in the art, can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (7)
1. the integrating device that a kind of active electric diacolation takes microring array, which is characterized in that including glass substrate (1), liquid inlet I
(2), liquid inlet II (3), electrode block (4), chip (5), liquid inlet III (6), fluid passage II (7), liquid outlet I (8),
Liquid outlet II (9), liquid inlet IV (10), fluid passage I (11), cuboid floor (12)；
The chip (5) is arranged on glass substrate (1), and the chip (5) is equipped with liquid inlet I (2), liquid inlet II
(3), liquid inlet III (6), liquid inlet IV (10), fluid passage I (11), fluid passage II (7), liquid outlet I (8), liquid
Body exports II (9)；Liquid inlet I (2), liquid inlet II (3) are connected with one end of fluid passage I (11), fluid passage I
(11) the other end is connected to after crossing with liquid inlet III (6), liquid inlet IV (10) with one end of fluid passage II (7), liquid
The other end in body channel II (7) is separately connected liquid outlet I (8), liquid outlet II (9), fluid passage I (11) and fluid passage
II (7) are in same level, and the fluid passage I (11) and fluid passage II (7) outside wall surface two sides are alternately equipped with transverse direction
The electrode block (4) of placement, and the electrode of phase the same side electrode plate (4) is identical, the electrode of different lateral electrode plates (4) is on the contrary, described
Fluid passage I (11) and fluid passage II (7) inside be equipped with one piece or more the cuboid floor (12) vertically placed.
2. the integrating device that a kind of active electric diacolation according to claim 1 takes microring array, it is characterised in that: the liquid
Every piece of electrode block (4) front end is equipped with one piece of cuboid floor (12) in body channel I (11) and fluid passage II (7).
3. the integrating device that a kind of active electric diacolation according to claim 1 takes microring array, it is characterised in that: the core
Piece (5) is made of PDMS polydimethyl siloxane material.
4. the integrating device that a kind of active electric diacolation according to claim 1 takes microring array, it is characterised in that: the liquid
The feed liquor direction of body entrance III (6) and liquid inlet IV (10) is vertical with fluid passage I (11) and fluid passage II (7).
5. the integrating device that a kind of active electric diacolation according to claim 1 takes microring array, it is characterised in that: the core
Piece (5) long 45mm, wide 15mm, thick 5mm；Glass substrate (1) the long 60mm, wide 25mm, thick 5mm.
6. the integrating device that a kind of active electric diacolation according to claim 2 takes microring array, it is characterised in that: the liquid
Body entrance I (2), liquid inlet II (3), liquid inlet III (6), liquid inlet IV (10), liquid outlet I (8), liquid outlet II
(9) diameter is 1mm, fluid passage I (11) and fluid passage II (7) width d2For 0.5mm, high h2For 0.35mm, cuboid
The wide d of floor (12)1For 0.2mm, long L1For 0.1mm, height h2For 0.35mm, the long L of every electrode plate (4)2For 0.7mm, width
d3For 0.15mm, height h1For 0.2mm.
7. a kind of take the integrating device of microring array to be extracted using a kind of any one of the claim 1 ~ 6 active electric diacolation
Integrated method, which is characterized in that specific steps are as follows: aqueous phase liquid first is injected to liquid inlet I (2), it is hydraulically full to water phase
Pipeline I (11) and fluid passage II (7) and after liquid outlet I (8), liquid outlet II (9) outflow, then simultaneously from liquid inlet
Aqueous phase liquid is injected in I (2), is injected with machine-phase liquid body from liquid inlet II (3), organic phase and water phase two-phase liquid enter liquid jointly
In body pipeline I (11), the extraction between water phase and oily phase is realized, fluid passage I (11) is externally provided with one piece or more of electrode plate
(4), it and in fluid passage I (11) is additionally provided with cuboid floor (12) corresponding with electrode plate (4), by electrode plate (4)
With cuboid floor (12) to the flow-disturbing of two-phase liquid, so that two-phase liquid is carried out hybrid extraction, improve effect of extracting, work as two-phase
Liquid inflow fluid pipeline I (11) forms cross with fluid passage II (7), liquid inlet III (6), liquid inlet IV (10)
Behind channel, liquid inlet III (6), liquid inlet IV (10) are passed through in organic phase liquid to fluid passage II (7), are carried out multistage
Extraction realizes that organic phase package aqueous phase liquid carries out liquid-liquid extraction, and liquid flows into fluid passage II (7), fluid passage II (7)
Outside is equipped with electrode plate (4), inside is equipped with cuboid floor (12), carries out flow-disturbing again, it is to be extracted after final liquid
The outflow from liquid outlet I (8), liquid outlet II (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811445823.XA CN109304094A (en) | 2018-11-29 | 2018-11-29 | A kind of active electric diacolation takes the integrating device and its extraction integrated approach of microring array |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811445823.XA CN109304094A (en) | 2018-11-29 | 2018-11-29 | A kind of active electric diacolation takes the integrating device and its extraction integrated approach of microring array |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109304094A true CN109304094A (en) | 2019-02-05 |
Family
ID=65223404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811445823.XA Pending CN109304094A (en) | 2018-11-29 | 2018-11-29 | A kind of active electric diacolation takes the integrating device and its extraction integrated approach of microring array |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109304094A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112844070A (en) * | 2020-12-02 | 2021-05-28 | 宁波诺丁汉大学 | Method for preparing polyvinylidene fluoride hollow film by microfluidics |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010006785A1 (en) * | 1997-04-28 | 2001-07-05 | J. Michael Ramsey | Method and apparatus for analyzing nucleic acids |
| CN107051304A (en) * | 2017-03-29 | 2017-08-18 | 海南大学 | A kind of active electric osmose micro-mixer of unsymmetric structure and electrode |
| CN206535499U (en) * | 2017-02-20 | 2017-10-03 | 海南大学 | A kind of iris type electric osmose micro-mixer |
| CN208060350U (en) * | 2018-04-13 | 2018-11-06 | 大连海事大学 | A kind of micro flow control chip device particle being carried out based on nano-micrometre combination of channels and cell sequence is detached and counted |
| CN108771884A (en) * | 2018-05-08 | 2018-11-09 | 昆明理工大学 | A kind of combined type hybrid extraction device and method |
| CN209451370U (en) * | 2018-12-21 | 2019-10-01 | 昆明理工大学 | A kind of AC Electric Heater micro mixing device of inclined field heating |
-
2018
- 2018-11-29 CN CN201811445823.XA patent/CN109304094A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010006785A1 (en) * | 1997-04-28 | 2001-07-05 | J. Michael Ramsey | Method and apparatus for analyzing nucleic acids |
| CN206535499U (en) * | 2017-02-20 | 2017-10-03 | 海南大学 | A kind of iris type electric osmose micro-mixer |
| CN107051304A (en) * | 2017-03-29 | 2017-08-18 | 海南大学 | A kind of active electric osmose micro-mixer of unsymmetric structure and electrode |
| CN208060350U (en) * | 2018-04-13 | 2018-11-06 | 大连海事大学 | A kind of micro flow control chip device particle being carried out based on nano-micrometre combination of channels and cell sequence is detached and counted |
| CN108771884A (en) * | 2018-05-08 | 2018-11-09 | 昆明理工大学 | A kind of combined type hybrid extraction device and method |
| CN209451370U (en) * | 2018-12-21 | 2019-10-01 | 昆明理工大学 | A kind of AC Electric Heater micro mixing device of inclined field heating |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112844070A (en) * | 2020-12-02 | 2021-05-28 | 宁波诺丁汉大学 | Method for preparing polyvinylidene fluoride hollow film by microfluidics |
| CN112844070B (en) * | 2020-12-02 | 2022-03-29 | 宁波诺丁汉大学 | Method for preparing polyvinylidene fluoride hollow film by microfluidics |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9126197B2 (en) | Pipettes, methods of use, and methods of stimulating an object of interest | |
| CN101250483B (en) | Combined splint microelectrode type micro-fluidic dielectrophoresis cell separation and enrichment chip | |
| US20160201024A1 (en) | Microfluidic devices and/or equipment for microfluidic devices | |
| CN209451370U (en) | A kind of AC Electric Heater micro mixing device of inclined field heating | |
| Xiang et al. | Inertial microfluidic syringe cell concentrator | |
| CN103103120A (en) | Integrated temperature controlled PCR-CE (polymerase chain reaction-capillary electrophoresis) micro-fluidic chip and preparation method thereof | |
| Čemažar et al. | Microfluidic devices for manipulation, modification and characterization of biological cells in electric fields–a review | |
| CN105457692B (en) | Microfluidic separation device and method | |
| CN203525731U (en) | Multistage sorting microfluidic device for rare cells | |
| CN108144659A (en) | Based on chip lab microflow control technique micro-structure assisted extraction device and method | |
| Wu et al. | Modular microfluidics for life sciences | |
| CN107523481A (en) | A kind of micro-nano biomone screening installation based on micro-fluidic chip | |
| Dudani et al. | Mediating millisecond reaction time around particles and cells | |
| CN106622408A (en) | Micro-fluidic chip based on MHD control | |
| Zhu et al. | Stackable micromixer with modular design for efficient mixing over wide Reynold numbers | |
| CN109304094A (en) | A kind of active electric diacolation takes the integrating device and its extraction integrated approach of microring array | |
| CN108993337A (en) | A kind of integrating device of drop fluid micro-reactor | |
| CN209451869U (en) | A kind of micro fluidic device for realizing multiplicity detection based on electroosmotic flow | |
| CN101301989A (en) | Microfluid drive and mixed structure, and use method thereof | |
| CN101059526B (en) | Method for driving fluid movement in micropassage using electric heat flow | |
| CN202315775U (en) | Micro hybrid device | |
| CN210022179U (en) | High-efficient extraction integrated device that mixes | |
| CN105912766A (en) | Electric nanofluid enrichment loss mechanism simulation method | |
| CN102500266A (en) | Quick micro-mixing device for high-viscosity solution | |
| TW200534916A (en) | A microfluidic mixer utilizing electroosmotic flow |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20211217 |