CN109303800A - A kind of lowering fat and protecting liver composition and its preparation method and application - Google Patents
A kind of lowering fat and protecting liver composition and its preparation method and application Download PDFInfo
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- CN109303800A CN109303800A CN201710617681.XA CN201710617681A CN109303800A CN 109303800 A CN109303800 A CN 109303800A CN 201710617681 A CN201710617681 A CN 201710617681A CN 109303800 A CN109303800 A CN 109303800A
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to food, drug, field of health care products, a kind of lowering fat and protecting liver composition and its preparation method and application is specifically provided.The composition is mainly formed by saussurea intybus, Herba Cistanches, Poria cocos, compatibility, has apparent lowering fat and protecting liver effect.Based on traditional Chinese medicine compatibility theory, it is guidance with modern pharmaceutical theory, determines the composition compatibility mutually to act synergistically.While lowering fat and protecting liver, passive protective physical fitness can also be enhanced, natural safety has no toxic side effect.
Description
Technical field
The present invention relates to drug, food and field of health care products, in particular to a kind of lowering fat and protecting liver composition and its preparation side
Method and application.
Background technique
Hyperlipidemia is the common disease frequently-occurring disease of the middle-aged and the old, is one of principal element of incidence of atherosclerosis, can
Cause serious cardiovascular and cerebrovascular disease, such as hypertension, coronary heart disease, cerebrovascular disease, senile dementia.As our people lives
Horizontal continuous improvement, the change of dietary structure, hyperlipidemia has been in high incidence trend.According to statistics, population of China hyperlipidemia
Disease incidence be about 20%~40%, there are about 80,000,000 people by patient at present, and daily still with the speed increase of ten thousand people.Therefore, early
Phase controls and treatment hyperlipidemia is extremely urgent in time.
Liver is in the metabolism of body, bile generation, removing toxic substances, blood coagulation, immune, heat generation and the adjusting of water and electrolyte
Very important effect is played, is one huge " chemical plant " in body.The trend risen year by year has been presented in its disease incidence,
Cirrhosis, hepatitis, liver ascites, alcoholic liver, liver cancer etc. belong to liver diseases, when this disease possesses longer treatment
Between, faster development speed, treatment difficulty is larger, and patient once suffers from obtaining liver diseases, the work for affecting patient of high degree
Make and live, but the traditional therapy of medically liver diseases is not ideal enough, can not effectively improve the quality of life of patient.
Chinese herbal medicine as natural drug, can selecting the acupoints according to the channel, and have bidirectional modulation, few side effects, noresidue, without drug resistance
The advantages that property.Patient body can mildly be improved using natural drug, incremental keeps body built-in system continuous
Improve.Therefore it provides a kind of can be of great significance with the composition that lowering fat and protecting liver acts on.
Summary of the invention
The present invention provides a kind of composition and its preparation method and application with lowering fat and protecting liver effect.The composition with
Witloof is main component, compatibility and mass percent are as follows: saussurea intybus 20-80%, Herba Cistanches 15-50%, Poria cocos 5-50%, the group
Closing can also add in several ingredients of Herba Epimedii, hawthorn, Chinese yam, pueraria lobata, Radix Glycyrrhizae, purple perilla, semen coicis, cassia seed in object compatibility
At least any one.
The present composition is prepared according to the following steps to obtain:
1. saussurea intybus 20-80% is dried, moisture takes the saussurea intybus dried less than 10%, and alcohol reflux extracts, and is concentrated under reduced pressure, obtains
To ethanol extract.
2. Herba Cistanches 15-50%, Poria cocos 5-50% dry, make moisture less than 10%, water mentions, and filtrate decompression is concentrated for filtering,
Obtain water extract.
3. quantitative ethanol extract and water extract is taken to mix concentration.
Preferably, the composition selects following compatibility: saussurea intybus 50-60%, Herba Cistanches 20-40%, Poria cocos 10-30%.
It is furthermore preferred that the composition selects following compatibility: saussurea intybus 55.9%, Herba Cistanches 30.8%, Poria cocos 13.3%.
Further, the composition can be used for preparing food, health care product, drug.
The beneficial effects of the present invention are: the present invention utilizes the mutual association between natural constituents based on drug matching theory
Same-action obtains lowering fat and protecting liver obvious effect, the simple composition of without side-effects and preparation method.In terms of microcosmic angle, this
The active constituent collective effect of composition each component, can improve the elasticity and permeability of blood vessel, and vasodilator is removed intravascular
Wall residue purifies blood, reduces the adherency of erythrocyte and leucocyte, reduces blood viscosity, improves blood circulation state
And hematopoietic function.And liver blood microcirculation can be improved, promote liver metabolism ability, liver cell anoxic conditions are changed
It is kind.Increase the synthesis of liver internal protein, promote liver cell RNA, DNA synthesis, promotes DNA synthesis and cell when hepatic tissue regeneration
Division growth process accelerates liver cell to regenerate along original reticular fibre bracket.Liver Glutathione peptide content increases simultaneously,
Content of triglyceride reduces, and promotes the effect of lipid-metabolism in the detoxification ability and liver of liver.
Specific embodiment
Example 1 group closes the preparation of object and its lowering fat and protecting liver chrysanthemum tea
1. saussurea intybus dries, make moisture less than 10%, take 55.9% saussurea intybus dried, 65% second of (mass weight) is measured with 10 times
Alcohol reflux extracts 3 times, each 2h, collects combined extract, is concentrated under reduced pressure, and temperature is 50 DEG C, and pressure 0.08MPa obtains second
Alcohol extracting thing.
2.30.8% Herba Cistanches and 13.3% Poria cocos use water boiling method, extract three times, and first time amount of water is 10 times of amounts, boil
2h is extracted in boiling, and second of amount of water is 8 times of amounts, boils and extracts 1.5h, and third time amount of water is 6 times of amounts, boils and extracts 1.5h, is closed
And filtrate, filtrate is sieved with 100 mesh sieve, filtrate decompression is concentrated, temperature is 60 DEG C, and pressure 0.08MPa obtains water extract.
3. quantitative ethanol extract and water extract is taken to be diluted with water, diluted concentration is controlled below 30% (mass fraction),
It using 50% chrysanthemum of total composition as carrier, is coated using above-mentioned dilution, weight gain to 200%.It is coated control condition:
It is 50-70 DEG C of temperature, fast after revolving speed 6-20r/min(is first slow), inlet air temperature is at 60-80 DEG C, 50-70 DEG C of outlet temperature.It has been coated
It is dried at being placed on 50 DEG C.
The preparation of 2 composition of embodiment and its coffee
1. saussurea intybus dries, moisture takes 50% saussurea intybus dried less than 10%, and 65% ethyl alcohol for measuring (mass weight) with 10 times returns
Stream extracts 3 times, each 2h, collects combined extract, is concentrated under reduced pressure, and temperature is 50 DEG C, and pressure 0.08MPa obtains ethyl alcohol and mentions
Take object.
2.20% Herba Cistanches and 30% Poria cocos use water boiling method, extract three times, and first time amount of water is 10 times of amounts, boil and mention
2h is taken, second of amount of water is 8 times of amounts, boils and extracts 1.5h, and third time amount of water is 6 times of amounts, boils and extracts 1.5h, merges filter
Liquid sieves with 100 mesh sieve filtrate, and filtrate decompression is concentrated, and temperature is 60 DEG C, and pressure 0.08MPa obtains water extract.
3. the resulting ethanol extract of step 1 and the resulting water extract mixing of step 2, dehydration receive cream, ground coffee are added
It, less than 1%, is mixed to moisture with vegetable fat powder (1:10:18) granulation, drying, is filling, being packaged to be finished product.
The preparation of lowering fat and protecting liver capsule of the embodiment 3 containing composition
1. saussurea intybus dries, moisture takes 55% saussurea intybus dried less than 10%, and 65% ethyl alcohol for measuring (mass weight) with 10 times returns
Stream extracts 3 times, each 2h, collects combined extract, is concentrated under reduced pressure, and temperature is 50 DEG C, and pressure 0.08MPa obtains ethyl alcohol and mentions
Take object.
2.30% Herba Cistanches and 15% Poria cocos use water boiling method, extract three times, and first time amount of water is 10 times of amounts, boil and mention
2h is taken, second of amount of water is 8 times of amounts, boils and extracts 1.5h, and third time amount of water is 6 times of amounts, boils and extracts 1.5h, merges filter
Liquid sieves with 100 mesh sieve filtrate, and filtrate decompression is concentrated, and temperature is 60 DEG C, and pressure 0.08MPa obtains water extract.
3. the resulting ethanol extract of step 1 and the resulting water extract mixing of step 2, are dried, crushed into fine powder, mistake
The wetting agent of fine powder quality 20% and the adhesive of fine powder quality 20% is added in 150 meshes, and softwood processed is prepared, and crosses 14 mesh Buddhist nuns
Dragon sieve granulation, dries to moisture 3% hereinafter, be fitted into No. 3 capsule shells at 70 DEG C, obtains the lowering fat and protecting liver capsule of this composition.
The fat-reducing effect verification test of 4 composition of embodiment
1, test material
SPF grades SD rat 130, male, weight 180g-200g, Shandong Province's Experimental Animal Center offer (credit number: SCXK
(Shandong) 20140007).High lipid food (20.0% sucrose, 15% lard, 1.2% cholesterol, 0.2% sodium taurocholate, suitable junket egg
White, calcium monohydrogen phosphate, mountain flour etc., remaining is basic feed).Bezafibrate (Jiangsu Vanguard Pharmaceutical Co., Ltd., lot number 151111).
(biological work is built up in Nanjing for triglycerides, total cholesterol, high-density lipoprotein cholesterol, low density lipoprotein cholesterol kit
Journey research institute).
2, test method
After rat adapts to 5 days under experimental situation, rat is randomly divided into 13 groups by weight, model group, Bezafibrate group
(100mg Kg-1), composition 1-10, Normal group, every group 10.
Normal group is fed with normal diet, remaining groups of animals is fed with above-mentioned high lipid food.Average every left side 23g daily
It is right.Normal group and model group stomach-filling physiological saline, other each daily stomach-fillings in afternoon of administration group are primary, and stomach-filling volume is 1mL/
100g rat.Successive administration 45 days, rat was freely intake.Experiment terminates evening before that day administration as last time, fasting.Monitoring
Rat body weight variation, food utilization, rat blood serum TG, TC, HDL-C, LDL-C content.
3, test result
All data withIt indicates, data is handled using SPSS19.0 software, carried out using the t method of inspection equal
Number compares.P < 0.05 is that difference is statistically significant.
1) changes of weight
Compared with Normal group, model group rats weight dramatically increases (P < 0.01), show obesity rat model modeling at
Function.It is compared with model group, the rat body weight significant decrease (P < 0.01) of Bezafibrate group, composition 1-7 group shows composition
There is apparent inhibiting effect to the weight gain of Fatty rat.The compatibility of composition 1-7 and each ingredient percent are shown in Table
1, composition is shown in Table 2 to the influence of rat model weight.Table 1 is the compatibility table of composition 1-7, and table 2 is that rat body weight changes table.
The compatibility table of 1 composition 1-7 of table
Composition 8 is to continue to be added to the Herba Epimedii for accounting for 3 total amount 10% of composition on the basis of composition 3.
Composition 9 continues to be added to the chrysanthemum for accounting for 3 total amount 10% of composition on the basis of composition 3.
Composition 10 is to continue to be added to the yam flour for accounting for 3 total amount 10% of composition and account for group on the basis of composition 3
Close the perilla herb oil of 3 total amount 0.5% of object.
2 rat body weight of table changes table
Note: the * P < 0.01 compared with Normal group；The #P < 0.01 compared with model group.
2) food utilization
Model group rats food ration significantly reduces compared with rats in normal control group, and food utilization increases (P < 0.01)；With mould
The comparison of type group, without significantly sexually revising, food utilization reduces composition group food ration.Composition is to rat model food consumption table
It is shown in Table 3.Table 3 is that rat feed consumes table.
3) rat blood serum TG, TC, HDL-C, LDL-C content
Compared with Normal group, model group rats serum TG, TC content significantly increase (P < 0.01 or P < 0.05)；With model
Group compares, and there was no significant difference with reduction to a certain degree by TG in Bezafibrate group, composition group rat blood serum, HDL-C content
It is significant to increase (P < 0.01 or P < 0.05).As the result is shown: composition has preferable effect for reducing blood fat to obese rat, wherein group
The lipid-lowering effect for closing object 4,5,6 is close, and the lipid-lowering effect of composition 1,2,3 is close, and the lipid-lowering effect of composition 4,5,6 is compared with group
It closes object 1,2,3 to increase, composition 7 is improved compared with the lipid-lowering effect of composition 1-6.And it is added on the basis of composition 7
Herba Epimedii, chrysanthemum, yam flour and perilla herb oil, lipid-lowering effect further increase compared with composition 7.Each composition is to model
The influence of rat blood serum biochemical indicator is shown in Table 4.Table 4 is rat blood serum changes of biochemical indexes table.
4 rat blood serum changes of biochemical indexes table of table
The test of 5 composition protect liver efficacy validation of embodiment
1, test material
SPF Kunming mice, female fifty-fifty, the 20 ± 2g of weight of hero, Shandong Province's Experimental Animal Center provide (credit number SCXK
(Shandong) 20140007).Bifendate (Guangzhou group of stars medicine company limited liability company, lot number IF40002).56 degree of strong, colourless liquor distilled from sorghum
White wine (Beijing is along prosperous agriculture limited liability company).Alanine aminotransferase (ALT) and aspartate transaminase (AST) are (by south
Bioengineering Research Institute's offer is built up in capital).
2, test method
After mouse adapts to 3 days under experimental situation, mouse is randomly divided into 13 groups by weight, model group, Bifendate group
(150mg Kg-1), Normal group, composition the 1-10, (group technology and the group technology in embodiment 5 of composition 1-10
It is identical) every group 10.Normal group and model group give the physiological saline of same dosage, the 10 points of fillings in the morning of remaining each group mouse
56 degree of stomach strong, colourless liquor distilled from sorghum white wine 16ml/Kg, continuous 15 days.Meanwhile daily each group in afternoon is administered by the weight of animals, bifendate
Group medication is that 150 mg Kg-1 are deprived of food but not water after mouse continuous gavage is administered 15 days, pluck eyeball afterwards for 24 hours and take blood, is separated
Serum measures glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease in serum.Liver is taken to claim liver weight in wet base, it is crosscutting at from right lobe of liver edge 1cm
One piece of hepatic tissue is fixed in 10% formalin, conventional to be dehydrated, paraffin section, to carry out histopathological examination and scoring.
3, test result
1) influence of the composition to model mice AST and ALT
Compared with Normal group, model group AST and ALT value are significantly raised (P < 0.05), compared with model group, bifendate
Group and composition group can reduce hepatic injury mouse AST and ALT(P < 0.05), there is certain protection to alcohol liver tissue injury
Effect.It the results are shown in Table 5.Table 5 is influence of the composition to model mice AST and ALT.
2) composition is sliced the hepatic tissue pathology of alcoholic liver injury
Normal group murine liver tissue structure under light microscopic is normal.Compared with Normal group, model group mouse liver cell is bright
Aobvious steatosis, cytoplasm is loose, interior visible fusion fat drips, while part of hepatocytes necrosis occurs；Bifendate group has less
Liver cell has fat drips vacuole, and core is clear, mouse adipose liver cell lesion situation be improved significantly；Composition 1-3 is compared with model group
Mouse Liver Prevalence makes moderate progress, and mouse hepatopathy situation makes moderate progress compared with composition 1-3 in composition 4-6, mouse in composition 7
Liver is clear in structure, and fat drips quantity significantly reduces, and visible clearly nucleus under mirror, effect is the most significant compared with composition 1-6,
Composition 8-10 effect is similar to the effect of composition 7.(wherein the slice map of composition 1-3 is by 1 generation of composition for the result is shown in Figure 1
Table, composition 4-6 slice map represented by composition 4, the slice map of composition 8-10 is represented by composition 8).Fig. 1 is combination
Hepatic tissue pathology slice map of the object to alcoholic liver injury.A. Normal group；B. model group；C. Bifendate group；D.
Composition 1-3 group；E. composition 4-6 group；F. composition 7-10 group.
Claims (13)
1. a kind of lowering fat and protecting liver composition, it is characterised in that according to mass percent meter, including following component: saussurea intybus 20-
80%, Herba Cistanches 15-50%, Poria cocos 5-50%.
2. composition according to claim 1, it is characterised in that the composition can also add Herba Epimedii, chrysanthemum,
Chinese yam, purple perilla oil component.
3. composition according to claim 1, it is characterised in that according to mass percent meter, including following component: Mao Ju
Lettuce 50-60%, Herba Cistanches 20-40%, Poria cocos 10-20%.
4. composition according to claim 1, it is characterised in that according to mass percent meter, including following component: Mao Ju
Lettuce 55.9%, Herba Cistanches 30.8%, Poria cocos 13.3%.
5. composition according to claim 1, it is characterised in that be prepared from the following steps: (1) saussurea intybus is dried,
Make moisture less than 10%, take the saussurea intybus dried, alcohol reflux extracts, and is concentrated under reduced pressure, obtains ethanol extract；(2) Herba Cistanches,
Poria cocos dries, and makes moisture less than 10%, and water mentions, and filtrate decompression is concentrated, obtains water extract by filtering；(3) quantitative ethyl alcohol is taken to mention
Object and water extract is taken to mix concentration.
6. the addition of Herba Epimedii ingredient in composition according to claim 2, which is characterized in that by Herba Epimedii and meat desert
Rong, Poria cocos dry together, make moisture less than 10%, and water mentions, and filtrate decompression is concentrated, obtains water extract by filtering.
7. the addition of chrysanthemum ingredient in composition according to claim 2, it is characterised in that its form added includes: chrysanthemum
Flower water extract, chrysanthemum dried flower.
8. the addition of Chinese yam ingredient in composition according to claim 2, it is characterised in that added in the form of yam flour
Into composition.
9. Herba Epimedii in composition according to claim 2, chrysanthemum, Chinese yam, purple perilla oil component additive amount be saussurea intybus
The 10-20% of quality.
10. the preparation step of composition according to claim 5, it is characterised in that the concentration of alcohol in step (1) is
65%。
11. the preparation step of composition according to claim 5, it is characterised in that ethyl alcohol described in step (3) extracts
The diluted concentration of object and water extract controls below 30% (mass fraction).
12. application of the composition according to claim 1 in terms of lowering fat and protecting liver.
13. application of the composition according to claim 1 in the food, drug, health care product for preparing lowering fat and protecting liver.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038098A (en) * | 2019-05-30 | 2019-07-23 | 广西圣特药业有限公司 | A kind of chrysanthemum Pu fresh breeze tea and preparation method thereof |
| CN116196377A (en) * | 2023-01-06 | 2023-06-02 | 福建省中医药科技开发有限公司 | Composition with liver protection effect and capable of accelerating alcohol metabolism, preparation method and application thereof |
-
2017
- 2017-07-26 CN CN201710617681.XA patent/CN109303800A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038098A (en) * | 2019-05-30 | 2019-07-23 | 广西圣特药业有限公司 | A kind of chrysanthemum Pu fresh breeze tea and preparation method thereof |
| CN116196377A (en) * | 2023-01-06 | 2023-06-02 | 福建省中医药科技开发有限公司 | Composition with liver protection effect and capable of accelerating alcohol metabolism, preparation method and application thereof |
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