CN109294242A - A kind of infant's nebulizer material and preparation method thereof - Google Patents
A kind of infant's nebulizer material and preparation method thereof Download PDFInfo
- Publication number
- CN109294242A CN109294242A CN201810967035.0A CN201810967035A CN109294242A CN 109294242 A CN109294242 A CN 109294242A CN 201810967035 A CN201810967035 A CN 201810967035A CN 109294242 A CN109294242 A CN 109294242A
- Authority
- CN
- China
- Prior art keywords
- infant
- nebulizer
- preparation
- mouth
- silicon oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/44—Block-or graft-polymers containing polysiloxane sequences containing only polysiloxane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2207/00—Properties characterising the ingredient of the composition
- C08L2207/04—Thermoplastic elastomer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Silicon Polymers (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation methods of infant's nebulizer material, include the following steps: the preparation of (one) fluorine silica polycondensate object；(2) single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；(3) it is kneaded；(4) it forms.The invention also discloses the infant's nebulizer materials being prepared according to the preparation method.The texture fidelity of infant's nebulizer material disclosed by the invention and breast of mothers is high, tear-proof, stretch-proof, anti-aging, high temperature resistant and resilience are excellent, the compliance of infant's atomization inspiration treatment can be improved, it is set to cooperate medical therapy to the maximum extent, material pliability is moderate and nontoxic, will not damage mucous membrane of mouth because of the frequent activity of infant.
Description
Technical field
The present invention relates to technical field of medical instrument more particularly to a kind of infant's nebulizer material and its preparations
Method.
Background technique
Fog inhalation therapy has become the various respiratory diseases up and down for the treatment of in global range, such as flu, fever, cough
It coughs, the trachea-bronchial epithelial cells such as asthma, abscess of throat, pharyngitis, rhinitis, bronchitis, pneumoconiosis, alveolar, the disease occurred in thoracic cavity
Prefered method and infantile respiratory disease conventional treatments.When being applied to infant, due to Infant Mentality and
Physiological particularity, sick child often to the sound generated in atomization process and quail by spraying and cry and scream it is more than, mismatch, and
It is bad that existing vaporizer mouth containing mouth prepares material property, more or less there is that hardness is larger, and disinfection is difficult, easy to aging, has
The defect of rubber smell causes treatment that can not continue, has not only wasted drug but also affected the treatment.Intravenously administrable etc., which can only be increased, wound
Property therapeutic modality, increases infants' pain and medical-risk.
Selection suitable material prepares breast nursing simulated mouth containing mouth, can eliminate infant's feared state of mind, makes it to greatest extent
Cooperate medical therapy, improves the compliance of infant's atomization inspiration treatment.Mouth containing mouth material in the prior art mainly have rubber,
Latex and silica gel three classes, rubber mouth containing mouth have rubber taste, and the formula of rubber compound adjusts difficulty, is easy to appear xanthochromia, and vulcanizing agent
In contain sulphur, be harmful to the human body；Latex sucks mouth pliability and elasticity is good, but its rubber taste for generally having one slight, makes
Color is gradually deepened during, and high temperature resistance is bad, it is easy to aging, therefore the time limit used is very short；The mouth containing of silica gel
Mouth can resist temperature change, can be boiled, surface is smooth, transparent, tasteless, resistance to ag(e)ing is good, but silica gel elasticity it is bad,
Surface is harder, and lear energy is poor.
Therefore, it is high to develop a kind of texture fidelity with breast of mothers, tear-proof, stretch-proof, anti-aging, high temperature resistant and returns
Elasticity is excellent, and the moderate breast nursing simulated mouth nozzle for atomizing inhalation device of baby of hardness is accorded with the demands of the market with material, has extensive
Market value.
Summary of the invention
In order to overcome the defects of the prior art, the present invention provide a kind of mouth nozzle for atomizing inhalation device of baby material and
Preparation method, it is the preparation method simple process, easy to operate；Make the texture of material and breast of mothers by Molecular Design
Fidelity is high, and tear-proof, stretch-proof, anti-aging, high temperature resistant and resilience are excellent, can be improved infant's atomization inspiration treatment according to
From property, it is made to cooperate medical therapy to greatest extent, material pliability is moderate and nontoxic, will not be due to the frequent activity of infant
Damage mucous membrane of mouth.
To achieve the above object of the invention, the technical solution adopted by the present invention is that, a kind of infant's nebulizer material
Preparation method, include the following steps:
The preparation of I fluorine silica polycondensate object: by two (chloromethyl) tetramethyl-disilazanes, bis- (3- amino -4- fluorophenyl) ketones
It is dissolved in high boiling solvent, and basic catalyst is added thereto, be stirred to react at 60-80 DEG C 15-20 hours, then thereto
Be added 1- amino benzotriazole, continue stirring 1-2 hour, after be cooled to room temperature, be precipitated in water, and by the polymer of precipitation use
Ethanol washing 3-5 times is finally placed in drying 12-18 hours at 90-100 DEG C of vacuum oven, obtains fluorine silica polycondensate object；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object being prepared by step I is dissolved in diformazan
Solution is formed in sulfoxide, then single-ended epoxy silicon oil and catalyst are added thereto, is stirred to react at 80-90 DEG C 10-15 hours,
Solvent is evaporated off in back spin, and is washed 3-5 times with isopropanol, then is placed in drying 10-15 hours at 50-60 DEG C of vacuum oven, obtains
Single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer, the thermoplastic polyurethane that will be prepared by step II
Elastomer is put on open mill and is kneaded, and adds organic amine catalyst, beats triangle bag and clot is 3-5 times each, slice is parked
For use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating,
Pressurization, heat preservation, is cooled to room temperature, obtains infant's nebulizer material.
Preferably, (chloromethyl) tetramethyl-disilazane, bis- (3- amino -4- fluorophenyl) ketones, height two described in step I
Boiling point solvent, basic catalyst, 1- amino benzotriazole mass ratio be 1:1:(6-10): (0.3-0.5): 0.1.
Preferably, the high boiling solvent is in dimethyl sulfoxide, n,N-Dimethylformamide, N-Methyl pyrrolidone
It is one or more of.
Preferably, the basic catalyst is selected from one of potassium carbonate, sodium carbonate, potassium hydroxide, sodium hydroxide or several
Kind.
Preferably, the object of fluorine silica polycondensate described in step II, dimethyl sulfoxide, single-ended epoxy silicon oil and catalyst mass ratio 1:
(3-5):(0.3-0.5):0.1。
Preferably, the catalyst is selected from least one of triethylamine, tetrabutylammonium bromide.
Preferably, single-ended epoxy silicon oil modified fluoro-silicone condensation polymer described in step III, thermoplastic polyurethane elastomer, organic
The mass ratio of amine catalyst is 1:(0.4-0.7): 0.05.
Further, the organic amine catalyst is preferably triethylamine.
Further, it is vacuumized described in step IV, vacuum degree is 5 × 10-2-5×10-3Pa；The heating speed of the heating
Rate is 20-40 DEG C/min, is warming up to 1500-2000 DEG C；The moulding pressure is 2 × 107-4×107Pa；The heat preservation of the heat preservation
Time is 15-20 minutes.
A kind of mouth nozzle for atomizing inhalation device of baby material, using the preparation of above-mentioned infant's nebulizer material
Method is prepared.
A kind of mouth nozzle for atomizing inhalation device of baby, using above-mentioned mouth nozzle for atomizing inhalation device of baby with material prepare and
At.
A kind of infant's nebulizer, using above-mentioned mouth nozzle for atomizing inhalation device of baby as mouth containing mouth.
The beneficial effects of adopting the technical scheme are that
1) mouth nozzle for atomizing inhalation device of baby material provided by the invention, it is preparation method simple process, easy to operate, make
It is easy to get with raw material, material pliability is moderate and nontoxic, will not damage mucous membrane of mouth because of the frequent activity of infant.
2) mouth nozzle for atomizing inhalation device of baby material provided by the invention, by Molecular Design make material with
The texture fidelity of breast of mothers is high, and tear-proof, stretch-proof, anti-aging, high temperature resistant and resilience are excellent, and infant's mist can be improved
The compliance for changing Inhalation in Treating, makes it cooperate medical therapy to greatest extent.
3) mouth nozzle for atomizing inhalation device of baby material provided by the invention, containing fluorine silica polycondensate object, comprehensive performance is more
Add excellent, introducing amino benzo triazole structure triazole blocked by 1- amino benzo, raising material anti-ultraviolet ageing ability；It will
Fluorine silica polycondensate object is blended to obtain blend with polyurethane termoplastic elastomer, so that material is provided simultaneously with fluorine silica polycondensate object and poly- ammonia
The advantages of ester thermoplastic elastomer (TPE), have excellent resilience, high temperature resistance, tear resistance, in forming process, material
Between can crosslink effect, form three-dimensional net structure, further increase the stability, heat-resisting quantity and tear resistance of material
Energy；Fluorine silica polycondensate object is modified by single-ended epoxy silicon oil, introduces long soft segment, one improves the rebound of material
Property, two come so that formed between strand it is certain unfold space, resilience can not only be improved, it may also be ensured that material softness degree
It is moderate, so that breast of its quality similar to mother, improves the curative compliance of infant.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Present invention raw material as used in the following examples is from upper Haiquan sunrise foreign trade Co., Ltd.
Embodiment 1
A kind of preparation method of infant's nebulizer material, includes the following steps:
The preparation of I fluorine silica polycondensate object: by two (chloromethyl) tetramethyl-disilazane 100g, bis- (3- amino -4- fluorophenyls)
Ketone 100g is dissolved in dimethyl sulfoxide 600g, and potassium carbonate 30g is added thereto, is stirred to react at 60 DEG C 15 hours, then to
1- amino benzotriazole 10g is wherein added, continues stirring 1 hour, after be cooled to room temperature, be precipitated in water, and by the poly- of precipitation
Object is closed with ethanol washing 3 times, drying 12 hours at 90 DEG C of vacuum oven is finally placed in, obtains fluorine silica polycondensate object；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object 100g being prepared by step I is dissolved in
Solution is formed in dimethyl sulfoxide 300g, then single-ended epoxy silicon oil 30g and triethylamine 10g is added thereto, is stirred at 80 DEG C anti-
It answers 10 hours, solvent is evaporated off in back spin, and is washed 3 times with isopropanol, then is placed in drying 10 hours at 50 DEG C of vacuum oven, obtains
Single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer 100g, the thermoplastic poly that will be prepared by step II
Urethane elastomer 40g, which is put on open mill, to be kneaded, and triethylamine 5g is added, and beats triangle bag and clot each 3 times, slice is parked
For use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating,
Pressurization, heat preservation, is cooled to room temperature, obtains infant's nebulizer material；Described to vacuumize, vacuum degree is 5 × 10-2Pa；
The heating rate of the heating is 20 DEG C/min, is warming up to 1500 DEG C；The moulding pressure is 2 × 107Pa；The guarantor of the heat preservation
The warm time is 15 minutes.
A kind of mouth nozzle for atomizing inhalation device of baby material, using the preparation of above-mentioned infant's nebulizer material
Method is prepared.
A kind of mouth nozzle for atomizing inhalation device of baby, using above-mentioned mouth nozzle for atomizing inhalation device of baby with material prepare and
At.
A kind of infant's nebulizer, using above-mentioned mouth nozzle for atomizing inhalation device of baby as mouth containing mouth.
Embodiment 2
A kind of preparation method of infant's nebulizer material, includes the following steps:
The preparation of I fluorine silica polycondensate object: by two (chloromethyl) tetramethyl-disilazane 100g, bis- (3- amino -4- fluorophenyls)
Ketone 100g is dissolved in n,N-Dimethylformamide 700g, and sodium carbonate 35g is added thereto, and it is small to be stirred to react 16 at 65 DEG C
When, then thereto be added 1- amino benzotriazole 10g, continue stirring 1.2 hours, after be cooled to room temperature, be precipitated in water, and will
The polymer of precipitation is finally placed in drying 13 hours at 92 DEG C of vacuum oven, is obtained fluorine silica polycondensate object with ethanol washing 4 times；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object 100g being prepared by step I is dissolved in
Solution is formed in dimethyl sulfoxide 350g, then single-ended epoxy silicon oil 35g and tetrabutylammonium bromide 10g is added thereto, at 83 DEG C
It is stirred to react 12 hours, solvent is evaporated off in back spin, and is washed 4 times with isopropanol, then to be placed at 53 DEG C of vacuum oven dry 11 small
When, obtain single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer 100g, the thermoplastic poly that will be prepared by step II
Urethane elastomer 50g, which is put on open mill, to be kneaded, and triethylamine 5g is added, and beats triangle bag and clot each 4 times, slice is parked
For use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating,
Pressurization, heat preservation, is cooled to room temperature, obtains infant's nebulizer material；Described to vacuumize, vacuum degree is 3 × 10-2Pa；
The heating rate of the heating is 25 DEG C/min, is warming up to 1600 DEG C；The moulding pressure is 2.5 × 107Pa；The heat preservation
Soaking time is 16 minutes.
A kind of mouth nozzle for atomizing inhalation device of baby material, using the preparation of above-mentioned infant's nebulizer material
Method is prepared.
A kind of mouth nozzle for atomizing inhalation device of baby, using above-mentioned mouth nozzle for atomizing inhalation device of baby with material prepare and
At.
A kind of infant's nebulizer, using above-mentioned mouth nozzle for atomizing inhalation device of baby as mouth containing mouth.
Embodiment 3
A kind of preparation method of infant's nebulizer material, includes the following steps:
The preparation of I fluorine silica polycondensate object: by two (chloromethyl) tetramethyl-disilazane 100g, bis- (3- amino -4- fluorophenyls)
Ketone 100g is dissolved in N-Methyl pyrrolidone 800g, and potassium hydroxide 40g is added thereto, and it is small to be stirred to react 18 at 70 DEG C
When, then thereto be added 1- amino benzotriazole 10g, continue stirring 1.5 hours, after be cooled to room temperature, be precipitated in water, and will
The polymer of precipitation is finally placed in drying 15 hours at 95 DEG C of vacuum oven, is obtained fluorine silica polycondensate object with ethanol washing 5 times；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object 100g being prepared by step I is dissolved in
Solution is formed in dimethyl sulfoxide 400g, then single-ended epoxy silicon oil 40g and triethylamine 10g is added thereto, is stirred at 85 DEG C anti-
It answers 13 hours, solvent is evaporated off in back spin, and is washed 5 times with isopropanol, then is placed in drying 13.5 hours at 56 DEG C of vacuum oven, obtains
To single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer 100g, the thermoplastic poly that will be prepared by step II
Urethane elastomer 60g, which is put on open mill, to be kneaded, and triethylamine 5g is added, and beats triangle bag and clot each 5 times, slice is parked
For use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating,
Pressurization, heat preservation, is cooled to room temperature, obtains infant's nebulizer material；Described to vacuumize, vacuum degree is 1 × 10-2Pa；
The heating rate of the heating is 30 DEG C/min, is warming up to 1800 DEG C；The moulding pressure is 3 × 107Pa；The guarantor of the heat preservation
The warm time is 18 minutes.
A kind of mouth nozzle for atomizing inhalation device of baby material, using the preparation of above-mentioned infant's nebulizer material
Method is prepared.
A kind of mouth nozzle for atomizing inhalation device of baby, using above-mentioned mouth nozzle for atomizing inhalation device of baby with material prepare and
At.
A kind of infant's nebulizer, using above-mentioned mouth nozzle for atomizing inhalation device of baby as mouth containing mouth.
Embodiment 4
A kind of preparation method of infant's nebulizer material, includes the following steps:
The preparation of I fluorine silica polycondensate object: by two (chloromethyl) tetramethyl-disilazane 100g, bis- (3- amino -4- fluorophenyls)
Ketone 100g is dissolved in high boiling solvent 900g, and basic catalyst 45g is added thereto, and it is small to be stirred to react 19 at 75 DEG C
When, then thereto be added 1- amino benzotriazole 10g, continue stirring 1.8 hours, after be cooled to room temperature, be precipitated in water, and will
The polymer of precipitation is finally placed in drying 17 hours at 98 DEG C of vacuum oven, is obtained fluorine silica polycondensate object with ethanol washing 4 times；
The high boiling solvent is that dimethyl sulfoxide, N,N-dimethylformamide, N-Methyl pyrrolidone 2:1:3 in mass ratio are mixed
Mixture；The basic catalyst be potassium carbonate, sodium carbonate, potassium hydroxide, sodium hydroxide 1:2:1:3 in mass ratio mixing and
At mixture；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object 100g being prepared by step I is dissolved in
Solution is formed in dimethyl sulfoxide 450g, then single-ended epoxy silicon oil 45g and catalyst 10g is added thereto, is stirred at 88 DEG C anti-
It answers 14 hours, solvent is evaporated off in back spin, and is washed 4 times with isopropanol, then is placed in drying 14 hours at 58 DEG C of vacuum oven, obtains
Single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；The catalyst is that triethylamine, tetrabutylammonium bromide 3:5 in mass ratio are mixed
Mixture；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer 100g, the thermoplastic poly that will be prepared by step II
Urethane elastomer 65g, which is put on open mill, to be kneaded, and triethylamine 5g is added, and beats triangle bag and clot each 5 times, slice is parked
For use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating,
Pressurization, heat preservation, is cooled to room temperature, obtains infant's nebulizer material；Described to vacuumize, vacuum degree is 8 × 10-2Pa；
The heating rate of the heating is 35 DEG C/min, is warming up to 1900 DEG C；The moulding pressure is 3.5 × 107Pa；The heat preservation
Soaking time is 19 minutes.
A kind of mouth nozzle for atomizing inhalation device of baby material, using the preparation of above-mentioned infant's nebulizer material
Method is prepared.
A kind of mouth nozzle for atomizing inhalation device of baby, using above-mentioned mouth nozzle for atomizing inhalation device of baby with material prepare and
At.
A kind of infant's nebulizer, using above-mentioned mouth nozzle for atomizing inhalation device of baby as mouth containing mouth.
Embodiment 5
A kind of preparation method of infant's nebulizer material, includes the following steps:
The preparation of I fluorine silica polycondensate object: by two (chloromethyl) tetramethyl-disilazane 100g, bis- (3- amino -4- fluorophenyls)
Ketone 100g is dissolved in dimethyl sulfoxide 1000g, and potassium carbonate 50g is added thereto, is stirred to react at 80 DEG C 20 hours, then to
1- amino benzotriazole 10g is wherein added, continues stirring 2 hours, after be cooled to room temperature, be precipitated in water, and by the poly- of precipitation
Object is closed with ethanol washing 5 times, drying 18 hours at 100 DEG C of vacuum oven is finally placed in, obtains fluorine silica polycondensate object；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object 100g being prepared by step I is dissolved in
Solution is formed in dimethyl sulfoxide 500g, then single-ended epoxy silicon oil 50g and tetrabutylammonium bromide 10g is added thereto, at 90 DEG C
It is stirred to react 15 hours, solvent is evaporated off in back spin, and is washed 5 times with isopropanol, then to be placed at 60 DEG C of vacuum oven dry 15 small
When, obtain single-ended epoxy silicon oil modified fluoro-silicone condensation polymer；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer 100g, the thermoplastic poly that will be prepared by step II
Urethane elastomer 70g, which is put on open mill, to be kneaded, and triethylamine 5g is added, and beats triangle bag and clot each 5 times, slice is parked
For use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating,
Pressurization, heat preservation, is cooled to room temperature, obtains infant's nebulizer material；Described to vacuumize, vacuum degree is 5 × 10-3Pa；
The heating rate of the heating is 40 DEG C/min, is warming up to 2000 DEG C；The moulding pressure is 4 × 107Pa；The guarantor of the heat preservation
The warm time is 20 minutes.
A kind of mouth nozzle for atomizing inhalation device of baby material, using the preparation of above-mentioned infant's nebulizer material
Method is prepared.
A kind of mouth nozzle for atomizing inhalation device of baby, using above-mentioned mouth nozzle for atomizing inhalation device of baby with material prepare and
At.
A kind of infant's nebulizer, using above-mentioned mouth nozzle for atomizing inhalation device of baby as mouth containing mouth.
Comparative example
This example provides a kind of breast milk and prevents true composite polyethylene material, and preparation method and formula are the same as Chinese invention patent CN
10643289A embodiment 1.
1-5 of the embodiment of the present invention mouth nozzle for atomizing inhalation device of baby being prepared and comparative example 1 is breast nursing simulated poly-
Ethylene composite material and pure silicon glue are tested for the property respectively, and test result and method are shown in Table 1
Table 1
As can be seen from the above table, mouth nozzle for atomizing inhalation device of baby disclosed by the embodiments of the present invention has more excellent
Mechanical property and anti-ultraviolet ageing, and hardness is smaller.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (10)
1. a kind of preparation method of infant's nebulizer material, which comprises the steps of:
The preparation of I fluorine silica polycondensate object: two (chloromethyl) tetramethyl-disilazanes, bis- (3- amino -4- fluorophenyl) ketones are dissolved in
In high boiling solvent, and basic catalyst is added thereto, is stirred to react at 60-80 DEG C 15-20 hours, then be added thereto
1- amino benzotriazole continues stirring 1-2 hours, after be cooled to room temperature, be precipitated in water, and by the polymer ethyl alcohol of precipitation
Washing 3-5 times is finally placed in drying 12-18 hours at 90-100 DEG C of vacuum oven, obtains fluorine silica polycondensate object；
II single-ended epoxy silicon oil modified fluoro-silicone condensation polymer: the fluorine silica polycondensate object being prepared by step I is dissolved in dimethyl sulfoxide
Middle formation solution, then single-ended epoxy silicon oil and catalyst are added thereto, 10-15 hours are stirred to react at 80-90 DEG C, back spin
Solvent is evaporated off, and is washed 3-5 times with isopropanol, then is placed in drying 10-15 hours at 50-60 DEG C of vacuum oven, obtains single-ended
Epoxy silicon oil modified fluoro-silicone condensation polymer；
III is kneaded: single-ended epoxy silicon oil modified fluoro-silicone condensation polymer, the thermoplastic polyurethane elastic that will be prepared by step II
Body is put on open mill and is kneaded, and adds organic amine catalyst, beats triangle bag and clot is 3-5 times each, slice is parked for use；
IV molding: the obtained film prepared by step III being placed in mold, high temperature furnace is put into, vacuumizes heating, is pressurizeed,
Heat preservation, is cooled to room temperature, obtains infant's nebulizer material.
2. the preparation method of infant's nebulizer material according to claim 1, which is characterized in that in step I
Described two (chloromethyl) tetramethyl-disilazane, bis- (3- amino -4- fluorophenyl) ketones, high boiling solvent, basic catalyst, 1-
The mass ratio of amino benzotriazole is 1:1:(6-10): (0.3-0.5): 0.1.
3. the preparation method of infant's nebulizer material according to claim 1, which is characterized in that described high boiling
Point solvent is selected from one or more of dimethyl sulfoxide, N,N-dimethylformamide, N-Methyl pyrrolidone.
4. the preparation method of infant's nebulizer material according to claim 1, which is characterized in that the alkalinity
Catalyst is selected from one or more of potassium carbonate, sodium carbonate, potassium hydroxide, sodium hydroxide.
5. the preparation method of infant's nebulizer material according to claim 1, which is characterized in that in step II
The fluorine silica polycondensate object, dimethyl sulfoxide, single-ended epoxy silicon oil and catalyst mass ratio 1:(3-5): (0.3-0.5): 0.1；Institute
It states catalyst and is selected from least one of triethylamine, tetrabutylammonium bromide.
6. the preparation method of infant's nebulizer material according to claim 1, which is characterized in that in step III
The single-ended epoxy silicon oil modified fluoro-silicone condensation polymer, thermoplastic polyurethane elastomer, organic amine catalyst mass ratio be 1:
(0.4-0.7):0.05；The organic amine catalyst is preferably triethylamine.
7. the preparation method of infant's nebulizer material according to claim 1, which is characterized in that in step IV
Described to vacuumize, vacuum degree is 5 × 10-2-5×10-3Pa；The heating rate of the heating is 20-40 DEG C/min, is warming up to
1500-2000℃；The moulding pressure is 2 × 107-4×107Pa；The soaking time of the heat preservation is 15-20 minutes.
8. a kind of baby that the preparation method for stating infant's nebulizer material using any one of claim 1-7 is prepared
Child's mouth nozzle for atomizing inhalation device material.
9. a kind of infant's nebulizer mouth being prepared using infant's nebulizer described in claim 8 with material
Containing mouth.
10. a kind of infant's Neulized inhalation using mouth nozzle for atomizing inhalation device of baby described in claim 9 as mouth containing mouth
Device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810967035.0A CN109294242B (en) | 2018-08-23 | 2018-08-23 | Material for infant aerosol inhaler and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810967035.0A CN109294242B (en) | 2018-08-23 | 2018-08-23 | Material for infant aerosol inhaler and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109294242A true CN109294242A (en) | 2019-02-01 |
| CN109294242B CN109294242B (en) | 2021-05-04 |
Family
ID=65165561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810967035.0A Active CN109294242B (en) | 2018-08-23 | 2018-08-23 | Material for infant aerosol inhaler and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109294242B (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283212A (en) * | 1997-12-22 | 2001-02-07 | 瓦克化学有限公司 | Organopolysiloxane materials which can be cross-linked by cleaving alcohols into elastomers |
| GB2355252A (en) * | 1999-10-14 | 2001-04-18 | Bespak Plc | Dispensing apparatus coated with a cold plasma polymerised silazane, siloxane or alkoxysilane |
| US20030148030A1 (en) * | 2001-06-12 | 2003-08-07 | Vernon Paul M. | Barrier coatings for elastomeric materials |
| CN2860505Y (en) * | 2005-12-31 | 2007-01-24 | 徐春玲 | Atomizing inhalator for trachea incision |
| CN101048448A (en) * | 2004-10-25 | 2007-10-03 | 南农股份公司 | Method of producing a silicone rubber item and the product obtainable by the method |
| CN101909683A (en) * | 2007-11-06 | 2010-12-08 | 3M创新有限公司 | Medicinal inhalation devices and components thereof |
| CN103547614A (en) * | 2011-03-21 | 2014-01-29 | 莫门蒂夫性能材料股份有限公司 | Organomodified carbosiloxane monomers containing compositions and uses thereof |
| CN104096301A (en) * | 2014-06-26 | 2014-10-15 | 张秀卿 | Aerosol inhalation device used in paediatric internal medicine |
| CN104341779A (en) * | 2014-10-28 | 2015-02-11 | 宁波爱乐宝婴儿用品有限公司 | Antibacterial nipple and preparation method thereof |
| CN205322943U (en) * | 2016-01-27 | 2016-06-22 | 崔伟 | Infant's atomizer mouth |
-
2018
- 2018-08-23 CN CN201810967035.0A patent/CN109294242B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283212A (en) * | 1997-12-22 | 2001-02-07 | 瓦克化学有限公司 | Organopolysiloxane materials which can be cross-linked by cleaving alcohols into elastomers |
| GB2355252A (en) * | 1999-10-14 | 2001-04-18 | Bespak Plc | Dispensing apparatus coated with a cold plasma polymerised silazane, siloxane or alkoxysilane |
| US20030148030A1 (en) * | 2001-06-12 | 2003-08-07 | Vernon Paul M. | Barrier coatings for elastomeric materials |
| CN101048448A (en) * | 2004-10-25 | 2007-10-03 | 南农股份公司 | Method of producing a silicone rubber item and the product obtainable by the method |
| CN2860505Y (en) * | 2005-12-31 | 2007-01-24 | 徐春玲 | Atomizing inhalator for trachea incision |
| CN101909683A (en) * | 2007-11-06 | 2010-12-08 | 3M创新有限公司 | Medicinal inhalation devices and components thereof |
| CN103547614A (en) * | 2011-03-21 | 2014-01-29 | 莫门蒂夫性能材料股份有限公司 | Organomodified carbosiloxane monomers containing compositions and uses thereof |
| CN104096301A (en) * | 2014-06-26 | 2014-10-15 | 张秀卿 | Aerosol inhalation device used in paediatric internal medicine |
| CN104341779A (en) * | 2014-10-28 | 2015-02-11 | 宁波爱乐宝婴儿用品有限公司 | Antibacterial nipple and preparation method thereof |
| CN205322943U (en) * | 2016-01-27 | 2016-06-22 | 崔伟 | Infant's atomizer mouth |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109294242B (en) | 2021-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103408946B (en) | Konjac glucomannan composite gel-containing baby nipple and preparation method thereof | |
| CN103494668A (en) | Medical hydrogel moisturizing eye care mask and preparation method thereof | |
| CN101152137B (en) | Body spray cream for baby and technique of preparing the same | |
| CN107602952A (en) | A kind of hypo-allergenic, antibacterial and mouldproof Heveatex sponge material, its preparation method and application | |
| CN113480852B (en) | Liquid silicone nipple and preparation method thereof | |
| CN108785581A (en) | One kind moistens the lung and relieve the cough oral solution and its preparation method and application of relievining asthma | |
| CN109294242A (en) | A kind of infant's nebulizer material and preparation method thereof | |
| CN107118403A (en) | A kind of ochre green tea latex product and its processing technology | |
| CN103788421B (en) | One-time exercise protects sound of baby talk cover and preparation method thereof | |
| CN116549675B (en) | Non-irritating medical ultrasonic coupling agent and preparation method thereof | |
| CN103550815A (en) | Preparation method of microporous polysaccharide microspheres | |
| CN102975321B (en) | Method for preparing condom by using polyisoprene rubber latex | |
| CN105031674A (en) | Disinfectant medical ultrasonic coupling agent and production process thereof | |
| CN106913899A (en) | Plant polyose styptic sponge is prepared using secondary freezing | |
| CN107320764A (en) | Ventilative medical dressing of a kind of moisturizing and preparation method thereof | |
| CN107286395A (en) | A kind of manufacture craft of the natural emulsion mattress of mold-proof oxidation-resistant | |
| CN107129603A (en) | A kind of ochre chrysanthemum latex product and its processing technology | |
| CN106377290A (en) | Drug-loaded titanium nail and preparation method thereof | |
| CN109021589A (en) | A kind of preparation method of sweat absorption and moisture emgloves | |
| CN110227175A (en) | It is a kind of with antibacterial, the medical dressing that can promote wound healing and preparation method thereof | |
| CN104491789A (en) | Traditional Chinese medicine formula for treating infantile pneumonia and preparation method for syrup of traditional Chinese medicine formula | |
| TWI653996B (en) | Airway device | |
| CN108264013A (en) | A kind of production method of latex silk quilt and latex silk quilt | |
| CN213250672U (en) | Disposable oxygen concentration maintaining hood for newborn | |
| CN109810303A (en) | A kind of antibacterial latex pillow and its processing technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210415 Address after: 400 700 Chongqing Beibei District Soil and Water High-tech Industrial Park No. 5 Yunhan Avenue with 190 Applicant after: RUNSHENG PHARMACY Co.,Ltd. Address before: 410205 463, 7th floor, Yannong complex building, Dongfanghong community, 459 Lusong Road, high tech Development Zone, Changsha City, Hunan Province Applicant before: HUNAN BOJUN BIOMEDICINE Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |