CN109289112A - A kind of tubing and preparation method thereof and catheter with pH instruction function - Google Patents
A kind of tubing and preparation method thereof and catheter with pH instruction function Download PDFInfo
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- CN109289112A CN109289112A CN201811425778.1A CN201811425778A CN109289112A CN 109289112 A CN109289112 A CN 109289112A CN 201811425778 A CN201811425778 A CN 201811425778A CN 109289112 A CN109289112 A CN 109289112A
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- tube body
- catheter
- tubing
- indicator
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0227—Materials having sensing or indicating function, e.g. indicating a pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3324—PH measuring means
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to medical instruments field more particularly to a kind of tubing with pH instruction function and preparation method thereof and catheters.The tube body material of catheter provided by the invention is from the tubing of research and development, and the tubing includes transparent tube body and is keyed to the pH indicator of the transparent tube body inner surface by chemistry.Catheter provided by the invention is provided with pH indicator in inboard wall of tube body, and the urine ph values for flowing through catheter can be monitored by way of discoloration, good for the real-time of urine ph values detection, high sensitivity；And the form of the transparent quality cooperation guiding-tube bend of catheter, it is exaggerated indicating effect again while obtaining indicator colouring information, convenient for observation；Simultaneously as pH indicator is to be fixed on the inboard wall of tube body of catheter by way of chemical bonding, therefore stability with higher, the dissociation that pH indicator does not occur durings urine washes away equal fall off, the period of warning is long, and biological safety is high.
Description
Technical field
The present invention relates to medical instruments field more particularly to a kind of tubing and preparation method thereof with pH instruction function and
Catheter.
Background technique
Self retaining catheter is technology common in clinical treatment and diagnosis, is sent out in terms of solving paruria and observation urine volume
Wave irreplaceable role.However catheter associated urinary tract infections are clinical most commonly seen one of nosocomial infections.Statistical number
According to display, urinary tract infections accounts for 40% or so of all hospital acquired infections, wherein 80% urinary tract infections is by self retaining catheter
Cause.
The development of catheter associated urinary tract infections, it is closely related with the crust of Preserving time catheter.Catheter crust master
It will be caused by urease secreting type bacterium (e.g., proteus mirabilis, proteus and providencia rettgeri).This be because
Specifically generation ammonia can be decomposed by catalyzing urea for the urease of such bacterial secretory, and urine is made to become alkalinity from slant acidity,
To promote calcium and magnesium ion in urine to be precipitated out to form crystallization.These crystallizations are deposited in bacterial biof iotalm, keep bacterium effective
The attack of host immune system and antibiotic is resisted on ground, to seriously reduce the effect of later period antibacterial therapy.In addition, urinary tract bacterium
Crystallobionts film is formed in catheter lumens, blocking pipeline simultaneously interferes urine to be discharged in time, will cause patient's pyelonephritis, loses
Blood disease or endotoxin shock are even dead.
Therefore, real-time monitoring flows through the urine pH of catheter, learn urease secreting bacteria to the invasion situation of urine, and
Early warning is made to catheter crust and blocking, it will help be urethral catheterization while rationally extending catheter service life
The confirmation that pipe associated urinary tract infections dispose the best opportunity provides reference frame.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of tubing with pH instruction function and preparation method thereof and leading
Urinary catheter, catheter provided by the invention real-time monitoring can flow through the urine ph values of catheter by way of discoloration.
The present invention provides a kind of tubing with pH instruction function, including transparent tube body and are keyed to institute by chemistry
State the pH indicator of transparent tube body inner surface.
Preferably, the material of the transparent tube body includes polyolefin, polyurethane, polyurethane, silicon rubber, latex and thermoplastic
One of property elastomer is a variety of.
Preferably, the pH indicator include bromothymol blue, alpha naphthol phthalein, thymol blue, curcumin, dimethyl diaminophenazine chloride and
It is one of phenol red or a variety of.
Preferably, the region area of the transparent tube body inner surface connection pH indicator accounts for the transparent tube body inner surface gross area
2~100%.
The present invention provides a kind of preparation methods of tubing described in above-mentioned technical proposal, comprising the following steps:
A) plasma pretreatment is carried out to the inner surface of transparent tube body, obtains the tube body of inner surface activation；
B) grafting liquid is added in the tube body of the inner surface activation, ultraviolet irradiation obtains inner surface graft modification
Tube body；
C) pH indicator, catalysts and solvents are added in the tube body of the inner surface graft modification, are reacted, is obtained
To the tubing with pH instruction function.
Preferably, in step b), contain graft in the grafting liquid；The graft includes hydroxy-ethyl acrylate, first
Base hydroxy-ethyl acrylate, hydroxypropyl acrylate, hydroxy propyl methacrylate, acrylic acid list polyethylene glycol, methacrylic acid list are poly-
One of ethylene glycol, methacrylic acid 2- amino ethyl ester and methyl propenoic acid glycidyl ether are a variety of.
Preferably, in step b), the wavelength of the ultraviolet irradiation is 180~420nm；The time of the ultraviolet irradiation is 5
~60min.
Preferably, in step c), the catalyst is sulfuric acid, phosphoric acid, sulfonic acid, ferric trichloride or alchlor.
Preferably, in step c), the temperature of the reaction is 20~120 DEG C；The time of the reaction is 0.5~12h.
The present invention provides a kind of catheter with pH instruction function, the tube body material of the catheter is above-mentioned technology
Tubing described in scheme.
Compared with prior art, the present invention provides a kind of tubing with pH instruction function and preparation method thereof and urethral catheterization
Pipe.The tube body material of catheter provided by the invention is from the tubing of research and development, and the tubing includes transparent tube body and passes through chemistry
It is keyed to the pH indicator of the transparent tube body inner surface.Catheter provided by the invention is indicated in inboard wall of tube body provided with pH
Agent can monitor the urine ph values for flowing through catheter by way of discoloration, good for the real-time of urine ph values detection, sensitivity
It is high；And the form of the transparent quality cooperation guiding-tube bend of catheter, it is exaggerated again while obtaining indicator colouring information
Indicating effect, convenient for observation；Simultaneously as pH indicator is the inboard wall of tube body for being fixed on catheter by way of chemical bonding
On, therefore stability with higher, the dissociation that pH indicator does not occur durings urine washes away equal fall off, warn the period
Long, biological safety is high.In the present invention, the urine ph values of catheter are flowed through by real-time monitoring, can learn that urease is secreted
Bacterium makes early warning to the invasion situation of urine, and to catheter crust and blocking, is guaranteeing catheter service life
Rationally extend simultaneously, and provides reference frame for the confirmation that catheter associated urinary tract infections dispose the best opportunity.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
The present invention provides a kind of tubing with pH instruction function, including transparent tube body and are keyed to institute by chemistry
State the pH indicator of transparent tube body inner surface.
Tubing provided by the invention includes transparent tube body and pH indicator.Wherein, the material material of the transparent tube body is preferably
In medical macromolecular materials, including but not limited to polyolefin, polyurethane, polyurethane, silicon rubber, latex and thermoplastic elastomer (TPE)
It is one or more；The polyolefin includes but is not limited to polyvinyl chloride；The hardness of the transparent tube body is preferably 60~90A,
Concretely 60A, 65A, 70A, 75A, 80A, 85A or 90A；The light transmittance of the transparent tube body is preferably 75~95%, specifically
It can be 75%, 78%, 80%, 83%, 85%, 88%, 90%, 92% or 95%.The present invention is specific to the transparent tube body
Structure snd size are not particularly limited, and those skilled in the art design the structure and selection urethral catheterization of transparent tube body according to actual needs
The size of pipe.
In the present invention, the pH indicator is keyed to the transparent tube body inner surface by chemistry, including but unlimited
In bromothymol blue, alpha naphthol phthalein, thymol blue, curcumin, dimethyl diaminophenazine chloride and one of phenol red or a variety of.The present invention is to upper
The source for stating pH indicator does not have special limitation, is using the pH indicator of mentioned kind well known to those skilled in the art
Can, it can such as use its commercial goods.
In the present invention, the region area of the transparent tube body inner surface connection pH indicator preferably accounts for table in transparent tube body
The 2~100% of the face gross area, concretely 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%,
17%, 20%, 22%, 25%, 27%, 30%, 32%, 35%, 37%, 40%, 42%, 45%, 47%, 50%, 52%,
55%, 57%, 60%, 62%, 65%, 67%, 70%, 72%, 75%, 77%, 80%, 82%, 85%, 87%, 90%,
92%, 95%, 97% or 100%.
The present invention also provides a kind of preparation methods of tubing described in above-mentioned technical proposal, comprising the following steps:
A) plasma pretreatment is carried out to the inner surface of transparent tube body, obtains the tube body of inner surface activation；
B) grafting liquid is added in the tube body of the inner surface activation, ultraviolet irradiation obtains inner surface graft modification
Tube body；
C) pH indicator, catalysts and solvents are added in the tube body of the inner surface graft modification, are reacted, is obtained
To the tubing with pH instruction function.
In method provided by the invention, plasma pretreatment is carried out to the inner surface of transparent tube body first.Wherein, institute
Transparent tube body hereinbefore by the agency of is stated, details are not described herein.During plasma is pretreated, gas used is preferred
For the one or more of air, oxygen, nitrogen, argon gas, hydrogen, ammonia and carbon dioxide；The flow velocity of the gas is preferably 2~
500cc/min, concretely 2cc/min, 5cc/min, 10cc/min, 20cc/min, 30cc/min, 40cc/min, 50cc/
min、100cc/min、150cc/min、200cc/min、250cc/min、300cc/min、350cc/min、400cc/min、
450cc/min or 500cc/min；The pretreated power of plasma is preferably 20~800W, concretely 20W, 30W,
40W、50W、60W、70W、80W、90W、100W、120W、150W、170W、200W、220W、250W、270W、300W、320W、
350W、370W、400W、420W、450W、470W、500W、520W、550W、570W、600W、620W、650W、670W、700W、
720W, 750W, 770W or 800W；The pretreated pressure of plasma is preferably 5~100Pa, concretely 5Pa, 10Pa,
15Pa、20Pa、25Pa、30Pa、35Pa、40Pa、45Pa、50Pa、55Pa、60Pa、65Pa、70Pa、75Pa、80Pa、85Pa、
90Pa, 95Pa or 100Pa；The plasma pretreated time is preferably 1~30min, concretely 1min, 5min,
10min, 15min, 20min, 25min or 30min.After plasma pre-processes, the tube body of inner surface activation is obtained.
After obtaining the tube body of inner surface activation, grafting liquid is added in the tube body of the inner surface activation.Wherein, described
Contain graft and solvent in grafting liquid；The graft include but is not limited to hydroxy-ethyl acrylate, hydroxyethyl methacrylate,
Hydroxypropyl acrylate, hydroxy propyl methacrylate, acrylic acid list polyethylene glycol, methacrylic acid list polyethylene glycol, metering system
One of sour 2- amino ethyl ester and methyl propenoic acid glycidyl ether are a variety of；The solvent include but is not limited to water, methanol,
Ethyl alcohol, isopropanol, ether, acetone, dimethylformamide, in dimethyl sulfoxide, chloroform and carbon tetrachloride it is one or more；Institute
Stating content of the graft in the grafting liquid is preferably 0.01~0.5g/mL, concretely 0.01g/mL, 0.03g/mL,
0.05g/mL、0.08g/mL、0.1g/mL、0.13g/mL、0.15g/mL、0.18g/mL、0.2g/mL、0.23g/mL、0.25g/
mL、0.28g/mL、0.3g/mL、0.33g/mL、0.35g/mL、0.38g/mL、0.4g/mL、0.43g/mL、0.45g/mL、
0.48g/mL or 0.5g/mL.In the present invention, the dosage of the grafting liquid is preferably the 2~100% of the tube body internal volume,
Concretely 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 17%, 20%, 22%, 25%,
27%, 30%, 32%, 35%, 37%, 40%, 42%, 45%, 47%, 50%, 52%, 55%, 57%, 60%, 62%,
65%, 67%, 70%, 72%, 75%, 77%, 80%, 82%, 85%, 87%, 90%, 92%, 95%, 97% or 100%.
After the grafting liquid addition, ultraviolet irradiation is carried out to tube body.Wherein, the light source of the ultraviolet irradiation is preferably low-pressure mercury
Lamp, medium pressure mercury lamp, high-pressure sodium lamp, iodine-tungsten lamp and add one or more of optical filter；The wavelength of the ultraviolet irradiation is preferably
180~420nm, concretely 180nm, 200nm, 220nm, 240nm, 254nm, 260nm, 280nm, 300nm, 320nm,
340nm, 360nm, 365nm, 380nm, 400nm or 420nm；The time of the ultraviolet irradiation is preferably 5~60min, specifically may be used
For 5min, 10min, 15min, 20min, 25min, 30min, 35min, 40min, 45min, 50min, 55min or 60min.It is purple
After external irradiation, the tube body after irradiation is washed, obtains the tube body of inner surface graft modification.
After obtaining the tube body of inner surface graft modification, pH indicator, catalysts and solvents are added to the inner surface and are connect
In the modified tube body of branch.Wherein, the pH indicator hereinbefore by the agency of, details are not described herein；The catalyst includes
But it is not limited to sulfuric acid, phosphoric acid, sulfonic acid, ferric trichloride or alchlor；The solvent includes but is not limited to water, methanol, ethyl alcohol, different
Propyl alcohol, ether, acetone, dimethylformamide, in dimethyl sulfoxide, chloroform, carbon tetrachloride it is one or more；The pH instruction
The ratio of the quality of agent and the pH indicator, catalysts and solvents total volume is preferably (0.01~20) g:100mL, concretely
0.01g:100mL、0.1g:100mL、0.5g:100mL、1g:100mL、3g:100mL、5g:100mL、8g:100mL、10g:
100mL, 12g:100mL, 15g:100mL, 18g:100mL or 20g:100mL；The quality of the catalyst and the pH are indicated
Agent, catalysts and solvents total volume ratio be preferably (0.01~5) g:100mL, concretely 0.01g:100mL, 0.1g:
100mL、0.3g:100mL、0.5g:100mL、0.8g:100mL、1g:100mL、1.5g:100mL、2g:100mL、2.5g:
100mL, 3g:100mL, 3.5g:100mL, 4g:100mL, 4.5g:100mL or 5g:100mL.The pH indicator, catalyst and
After solvent adds, reacted.Wherein, the temperature of the reaction is preferably 20~120 DEG C, concretely 20 DEG C, 25 DEG C,
30℃、35℃、40℃、45℃、50℃、55℃、60℃、65℃、70℃、75℃、80℃、85℃、90℃、95℃、100℃、
105 DEG C, 110 DEG C, 115 DEG C or 120 DEG C；The time of the reaction is preferably 0.5~12h, concretely 0.5h, 1h, 1.5h,
2h、2.5h、3h、3.5h、4h、4.5h、5h、5.5h、6h、6.5h、7h、7.5h、8h、8.5h、9h、9.5h、10h、10.5h、
11h, 11.5h or 12h.After reaction, the tube body after reaction is washed and is dried, obtained provided by the invention with pH
Indicate the tubing of function.
Tubing provided by the invention is provided with pH indicator in its inner wall, can be monitored by way of discoloration and flow through tubing
Liquid pH value, high sensitivity good for the real-time of liquid pH value detection；And the transparent quality cooperation guiding-tube bend of tubing
Form is exaggerated indicating effect while obtaining indicator colouring information again, convenient for observation；Simultaneously as pH indicator is
It is fixed on by way of chemical bonding on the inboard wall of tube body of tubing, therefore stability with higher, washes away and waited in liquid
The dissociation that pH indicator does not occur in journey falls off, and the period of warning is long, and biological safety is high.
The present invention also provides a kind of catheter with pH instruction function, the tube body material of the catheter is above-mentioned skill
Tubing described in art scheme.
Catheter provided by the invention is provided with pH indicator in inboard wall of tube body, can monitor to flow through by way of discoloration and lead
The urine ph values of urinary catheter, high sensitivity good for the real-time of urine ph values detection；And the transparent quality cooperation of catheter is led
Curved form is managed, is exaggerated indicating effect again while obtaining indicator colouring information, convenient for observation；Simultaneously as pH
Indicator is fixed on the inboard wall of tube body of catheter by way of chemical bonding, therefore stability with higher is being urinated
The dissociation that pH indicator does not occur during washing away etc. for liquid falls off, and the period of warning is long, and biological safety is high.In the present invention, lead to
The urine ph values that real-time monitoring flows through catheter are crossed, can learn urease secreting bacteria to the invasion situation of urine, and to urethral catheterization
Early warning is made in pipe crust and blocking, and reasonable in guarantee catheter service life extends simultaneously, and urinate for catheter correlation
The confirmation of road feel dye disposition best opportunity provides reference frame.
For the sake of becoming apparent from, it is described in detail below by following embodiment.
Embodiment 1
Urinary tract bacterium infection is prepared to warn type catheter
A) polyvinyl chloride catheter (hardness 70A, light transmittance 92%) is pre-processed with plasma, running parameter are as follows:
Power 200W, pressure 15Pa, oxygen gas, flow velocity 30cc/min, time 5min, obtain the catheter of surface active.
B) compound concentration is the aqueous solution of 0.05g/mL hydroxyethyl methacrylate, is added to the catheter of surface active
In inner cavity, solution usage is the 100% of catheter lumens volume；It is shone with the high-pressure sodium lamp that wavelength is 254nm, power is 300W
20min is penetrated, is then washed with ethyl alcohol, deionized water sonic oscillation, obtains the catheter of surface graft modification；
C the acetone mixed solution of 0.05g/mL bromothymol blue and 0.01g/mL sulfuric acid) is added to above-mentioned surface to connect
In the inner cavity of the modified catheter of branch, until solution is full of entire inner cavity；Reaction 4h is carried out at a temperature of 60 DEG C later, indicates pH
Agent is chemically bonded on the inner wall of catheter；Sample with ethanol, the washing of deionized water sonic oscillation, vacuum drying are had
The catheter of pH instruction function.
Embodiment 2
A) polyurethane guide urinary catheter (hardness 80A, light transmittance 88%) is pre-processed with plasma, running parameter are as follows: function
Rate 60W, pressure 15Pa, air gas, flow velocity 20cc/min, time 15min, obtain the catheter of surface active.
B) compound concentration is the aqueous solution of 0.1g/mL methacrylic acid 2- amino ethyl ester, is added to the urethral catheterization of surface active
In the inner cavity of pipe, solution usage is the 20% of catheter lumens volume；With the high-pressure mercury that wavelength is 365nm, power is 300W
Light irradiation 10min is then washed with ethyl alcohol, deionized water sonic oscillation, obtains the catheter of surface graft modification；
C the acetone mixed solution of 0.05g/mL alpha naphthol phthalein and 0.005g/mL sulfuric acid) is added to above-mentioned surface grafting to change
Property catheter inner cavity in, until solution be full of entire inner cavity；Reaction 12h is carried out at a temperature of 40 DEG C later, makes pH indicator
It is chemically bonded on the inner wall of catheter；Sample with ethanol, the washing of deionized water sonic oscillation, vacuum drying are obtained with pH
Indicate the catheter of function.
Embodiment 3
Urinary tract bacterium infection is prepared to warn type catheter
A) silica fubber cathete (hardness 75A, light transmittance 80%) is pre-processed with plasma, running parameter are as follows: function
Rate 400W, pressure 40Pa, oxygen gas, flow velocity 40cc/min, time 30min, obtain the catheter of surface active.
B) compound concentration is the aqueous solution of 0.05g/mL methacrylic acid list polyethylene glycol, is added to the urethral catheterization of surface active
In the inner cavity of pipe, solution usage is the 80% of catheter lumens volume；With the high-pressure mercury that wavelength is 365nm, power is 300W
Light irradiation 10min is then washed with ethyl alcohol, deionized water sonic oscillation, obtains the catheter of surface graft modification；
C the acetone mixed solution of 0.1g/mL bromothymol blue and 0.01g/mL sulfuric acid) is added to above-mentioned surface grafting
In the inner cavity of modified catheter, until solution is full of entire inner cavity；Reaction 8h is carried out at a temperature of 70 DEG C later, makes pH indicator
It is chemically bonded on the inner wall of catheter；Sample with ethanol, the washing of deionized water sonic oscillation, vacuum drying are obtained with pH
Indicate the catheter of function.
Embodiment 4
Discoloration test
It is 10 that bacterial concentration is introduced in sterile artificial's urine of pH 6.110The bacillus variabilis of cfu/ml, culture for 24 hours, obtain
The bacterium infection artificial urine (pH=7.6) obtained.Sterile artificial's urine is injected separately into the catheter of Examples 1 to 3 preparation
With bacterium infection artificial urine, the color change in region of warning in catheter is recorded.
The color of 1 catheter of table under various circumstances
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Color in air | Yellow | Light brown | Light orange |
| Sterile artificial's urine, pH6.1 | Yellow | Light brown | Crocus |
| Infect artificial urine, pH7.6 | Navy blue | Black | Blue-green |
It can be seen from Table 1 that catheter provided by the invention has apparent color difference in different pH urines, say
Bright catheter provided by the invention can effectively monitor the urine pH for flowing through catheter, and learn urease secreting bacteria pair with this
The invasion situation of urine.
Embodiment 5
The test of catheter simulated infection
The catheter of Examples 1 to 3 preparation is connected with the infusion bag (simulation bladder) for filling artificial urine, toward infusion bag
In fresh sterile artificial's urine is pumped into the flow velocity of 0.75mL/min, make infusion bag urine keep discharge-injection dynamic
Equilibrium state and amount of urine maintain 20mL or so (37 DEG C).When experiment starts, 0.1mL bacillus variabilis is injected toward infusion bag
(1010cfu/ml).Record catheter is warned the time of discoloration and pipeline blockage respectively.
2 catheter of table is warned discoloration, the time of pipeline blockage and catheter pre-warning time
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Average value | |
| Warn Coloring Time/h | 24 | 22 | 26 | 24 |
| The pipeline blockage time/h | 54 | 48 | 66 | 56 |
| Pre-warning time/h | 30 | 26 | 40 | 32 |
It can be seen from Table 2 that catheter provided by the invention does catheter crust and blocking in simulated infection test
It is up to the pre-warning time of 40h out.Since simulated experiment takes the bacterial concentration occurred much higher than practical infection event, urine
The bacterium infection pre-warning time of type catheter in actual use of warning in road will further extend, this will be urinated for catheter correlation
Time enough is striven in the disposition of road feel dye.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of tubing with pH instruction function, including transparent tube body and table in the transparent tube body is keyed to by chemistry
The pH indicator in face.
2. tubing according to claim 1, which is characterized in that the material of the transparent tube body include polyolefin, polyurethane,
One of polyurethane, silicon rubber, latex and thermoplastic elastomer (TPE) are a variety of.
3. tubing according to claim 1, which is characterized in that the pH indicator includes bromothymol blue, alpha naphthol
Phthalein, thymol blue, curcumin, dimethyl diaminophenazine chloride and one of phenol red or a variety of.
4. tubing according to claim 1, which is characterized in that the region of the transparent tube body inner surface connection pH indicator
Area accounts for the 2~100% of the transparent tube body inner surface gross area.
5. a kind of preparation method of any one of Claims 1 to 4 tubing, comprising the following steps:
A) plasma pretreatment is carried out to the inner surface of transparent tube body, obtains the tube body of inner surface activation；
B) grafting liquid is added in the tube body of the inner surface activation, ultraviolet irradiation obtains the tube body of inner surface graft modification；
C) pH indicator, catalysts and solvents are added in the tube body of the inner surface graft modification, are reacted, is had
There is the tubing of pH instruction function.
6. preparation method according to claim 5, which is characterized in that in step b), contain graft in the grafting liquid；
The graft includes hydroxy-ethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxy propyl methacrylate, third
Olefin(e) acid list polyethylene glycol, methacrylic acid list polyethylene glycol, methacrylic acid 2- amino ethyl ester and methyl propenoic acid glycidyl
One of ether is a variety of.
7. preparation method according to claim 5, which is characterized in that in step b), the wavelength of the ultraviolet irradiation is 180
~420nm；The time of the ultraviolet irradiation is 5~60min.
8. preparation method according to claim 5, which is characterized in that in step c), the catalyst be sulfuric acid, phosphoric acid,
Sulfonic acid, ferric trichloride or alchlor.
9. preparation method according to claim 5, which is characterized in that in step c), the temperature of the reaction is 20~120
℃；The time of the reaction is 0.5~12h.
10. a kind of catheter with pH instruction function, which is characterized in that the tube body material of the catheter is claim 1
~4 described in any item tubing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811425778.1A CN109289112B (en) | 2018-11-27 | 2018-11-27 | Pipe with pH indicating function, preparation method thereof and catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811425778.1A CN109289112B (en) | 2018-11-27 | 2018-11-27 | Pipe with pH indicating function, preparation method thereof and catheter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109289112A true CN109289112A (en) | 2019-02-01 |
| CN109289112B CN109289112B (en) | 2021-05-04 |
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ID=65143764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811425778.1A Active CN109289112B (en) | 2018-11-27 | 2018-11-27 | Pipe with pH indicating function, preparation method thereof and catheter |
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|---|---|
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Cited By (1)
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