CN109288745A - A kind of tender skin maintenance cosmetic composition and preparation method thereof - Google Patents
A kind of tender skin maintenance cosmetic composition and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The present invention provides a kind of tender skins to conserve cosmetic composition.Specifically, the composition contains scarce atelocollagen, soluble collagen cross-linked polymer, collagenous amino acids, lactoglobulin and yeast tunning extract.The effect of composition of the invention not only can make elasticity of skin tender, delaying skin aging, additionally aid the growth chemotactic of sensibility, impaired property skin cell, and concertedness promotees skin inflammatory resolution, integrate moisturizing of moistening, anti-ageing soft, maintenance skin barrier.
Description
Technical field
The invention belongs to field of biotechnology, and in particular to a kind of tender skin maintenance cosmetic composition and preparation method thereof.
Background technique
With the rapid development of social economy, people's lives level is also higher and higher, and more and more women start weight
Depending on beauty and skin care, skin care product is begun to use to improve the skin problem of oneself.
However, the product level of Cosmetic Market is uneven at present, some product prices are high, some product overnutritions,
It is born more than skin, along with the continuous deterioration of living environment, or even is easy to enable skin to be irritated and sensitive, serious meeting
Cause chronic injury.Some products or bad or skin sense of arranging in pairs or groups are bad, or are unable to reach the effect of declared, or
Some violated raw materials are added to reach the effect of getting instant result, to not be able to satisfy consuming public's demand.
Therefore, there is an urgent need in the art to develop with moisturizing, anti-anaphylaxis, repair, and moderate, safety temperature
With the cosmetics not irritated to human body.
Summary of the invention
It is an object of the invention to provide a kind of tender skin maintenance cosmetic compositions and preparation method thereof.
In the first aspect of the present invention, a kind of composition is provided, the composition contains:
(a) atelocollagen is lacked；
(b) soluble collagen cross-linked polymer；
(c) collagenous amino acids；
(d) lactoglobulin；With
(e) yeast tunning extract.
In another preferred example, the composition contains:
(a) 5-20 parts by weight, the preferably scarce atelocollagen of 10-15 parts by weight；
(b) 5-20 parts by weight, preferably the soluble collagen cross-linked polymer of 10-15 parts by weight；
(c) 1-5 parts by weight, preferably the collagenous amino acids of 3-5 parts by weight；
(d) 1-5 parts by weight, the preferably lactoglobulin of 3-5 parts by weight；
(e) 1-5 parts by weight, preferably the yeast tunning extract of 3-5 parts by weight；With
(f) excess water.
In another preferred example, the composition contains:
(a) 5-20%, the preferably scarce atelocollagen of 10-15%；
(b) 5-20%, preferably the soluble collagen cross-linked polymer of 10-15%；
(c) 1-5%, preferably the collagenous amino acids of 3-5%；
(d) 1-5%, the preferably lactoglobulin of 3-5%；
(e) 1-5%, preferably the yeast tunning extract of 3-5%；With
(f) excess water；
Wherein, the content is based on the total weight of the composition.
In another preferred example, the collagenous amino acids is selected from the group: glycine, serine, aspartic acid, the third ammonia
Acid, proline, hydroxyproline, or combinations thereof.
In another preferred example, the soluble collagen cross-linked polymer is that the crosslinked method of collagen of artificial preparation synthesis is drawn
Enter the high molecular crosslink polymer that the crosslinking of covalent bond obtains.
In another preferred example, the soluble collagen cross-linked polymer is the cross-linking agent of collagen and hyaluronic acid.
In another preferred example, the composition is used to prepare cosmetics.
In the second aspect of the present invention, the purposes of composition as described in the first aspect of the invention is provided, is used to prepare
Cosmetics.
In another preferred example, the cosmetic composition is used for: tender skin maintenance, moisturizing, anti-inflammatory, after-sun recovery, reparation
Skin barrier, repair uv induction DNA damage, whitening, light spot, it is anti-saccharification, or combinations thereof.
In the third aspect of the present invention, a kind of cosmetics are provided, the cosmetics contain (a) first aspect present invention institute
The composition stated；(b) acceptable carrier or excipient on cosmeceutical.
In another preferred example, the cosmetics contain:
(a) 5-15%, the preferably scarce atelocollagen of 10-15%；
(b) 1020%, the preferably soluble collagen cross-linked polymer of 10-15%；
(c) 1-5%, preferably the collagenous amino acids of 3-5%；
(d) 1-5%, the preferably lactoglobulin of 3-5%；
(e) 1-5%, preferably the yeast tunning extract of 3-5%；With
(f) water；
Wherein content is based on the total weight of the composition.
In another preferred example, acceptable carrier or excipient are selected from the group on the cosmeceutical: moisturizer, antioxygen
Agent, UV resistant agent, preservative, film forming agent, oil-soluble gelating agent, organo-clay mineral, resin, antibacterial agent, perfume (or spice)
Essence, salt, pH adjusting agent, chelating agent, freshener, anti-inflammatory agent, skin beautification with ingredient, vitamin, amino acid, nucleic acid, hormone,
Inclusion compound or combinations thereof.
In another preferred example, acceptable carrier or excipient are water on the cosmeceutical.
In another preferred example, in the cosmetics, the ratio of the composition and water is 1:1-10, preferably 1:4-
5。
In another preferred example, the cosmetics further include additional component selected from the group below: whitening or nti-freckle ingredient, anti-inflammatory
Ingredient, antioxidant content, uvioresistant ingredient, or combinations thereof.
In another preferred example, the dosage form of the cosmetics be solid dosage forms, semisolid dosage form or liquid dosage form, such as it is molten
Liquid, gel, cream, lotion, paste, creme, paste, cake, pulvis, patch etc..
In another preferred example, the cosmetic composition is used for: tender skin maintenance, moisturizing, anti-inflammatory, after-sun recovery, reparation
Skin barrier, repair uv induction DNA damage, whitening, light spot, it is anti-saccharification, or combinations thereof.
In the fourth aspect of the present invention, a kind of method for preparing cosmetics described in third aspect present invention is provided,
It is characterized in that, comprising the following steps:
(a) composition in first aspect present invention is provided；
(b) composition in step (a) is mixed with carrier acceptable on cosmeceutical, to obtain cosmetics.
It should be understood that above-mentioned each technical characteristic of the invention and having in below (eg embodiment) within the scope of the present invention
It can be combined with each other between each technical characteristic of body description, to form a new or preferred technical solution.As space is limited, exist
This no longer tires out one by one states.
Detailed description of the invention
Fig. 1 shows the general pore area of skin, big pore area, luminance difference and colour difference after 3 days facial masks of continuous use
Improvement.
Fig. 2 shows three spiral of type i collagen and loop structure schematic diagram.
Specific embodiment
The present inventor after extensive and in-depth study, has unexpectedly discovered a kind of tender skin maintenance cosmetic combinations for the first time
Object, the present composition use the active constituent of specific proportion, not only elasticity of skin can be made tender, delaying skin aging, also
Facilitate the growth chemotactic of sensibility, impaired property skin cell, concertedness promotees skin inflammatory resolution, collects moist moisturizing, anti-ageing tender
The effect of cunning, maintenance skin barrier, is integrated, and on this basis, completes the present invention.
Skin is overlying on body surface, and the first line of defence extraneous as human body confrontation, collagen is the main component of corium, is skin
Support and protection are provided, a variety of collagen productions and specific active constituent are optimized compounding by the present invention, with macromolecular collagen
With a variety of small molecules being rich in crosslinked film forming skin care surface layer and collagenous amino acids and yeast tunning extract
Nutrition needed for aminoacid ingredient osmotic absorption assigns skin assigns product merrily and lightheartedly ventilative good skin while moisturizing
Impression improves pachylosis, drying, low and deep appearance, skin care barrier moisturizing water lock to fragile, sensitive skin maintenance
Ability have superior effect.
Lactoglobulin
In a preferred embodiment of the invention, polymer is the protein main chain with the group containing lipophilic side chain
Heteropolymer.Heteropolymer has strong attraction to oil, but cannot be penetrated into oil due to protein main chain.Heteropolymer is attached to oil,
By oil decomposition at drop, and drop is trapped in film, so that oil droplet and the cosmetic composition based on powder be separated, and is prevented
Only oily aggregation and oil are penetrated to the surface of powder composition.Such heteropolymer has been used in foundation emulsion so that sebum deposits
Object normalization controls the alternative of skin lipid flowing as powder foundation is used.Preferably, heteropolymer includes 100-
300 repetitive units or residue, total molecular weight 10kDa-30kDa.The example of such heteropolymer may include C2-C16
Acylated (acetylated) lactoglobulin, such as can be used as Bio-Pol OE and obtained from Arch Personal Care Products
The C8-C16 isoalkyl succinyl group lactoglobulin sodium sulfonate or its derivative based on plant obtained, such as C8-C16 isoalkyl
Succinyl group soybean protein sodium sulfonate or C8-C16 isoalkyl succinyl group wheat gluten sodium sulfonate, respectively as VegePol
Or VegePol W is obtained, and can both be obtained from Arch Personal Care Products.Include sterol (such as cholesteric
Alcohol) or the heteropolymer of fatty acid (such as linoleic acid) can also be used in composition of the invention.
Yeast tunning extract
The present composition further includes yeast tunning extract.Grape yeast tunning filtrate in the present invention
(INCI: fission yeast (SCHIZOSACCHAROMYCES) mycelium fermentation Product filtrate), from Spain's Canary Islands
The separation of Listan grape.It is usually used by people to make grape wine, is rich in small molecule ferment substance, be otherwise known as " Portugal
Grape ferment ", for skin activity, glossiness, elasticity all has the effect of outstanding；Skin Cell can be rebuild, promote elastic force
Protein and the metabolism for updating skin corium, it is possible to reduce signs of skin aging, to Skin Cell active regeneration and collagen egg
White matter synthesis has good facilitation, plays whitening, special efficacy moisturizing, gloss skin, the multiple work such as enhancing elasticity in the product
With.Yeast tunning extract of the invention is commercial product, commercially available.It is preferred that aiming at cosmetic field producing and selling
Raw material.
Collagenous amino acids
The protein material for the macromolecular that collagen is made of 18 kinds of amino acid, the present invention contained by collagenous amino acids master
The amino acid nutrient combination of collagen is constituted for glycine, serine, aspartic acid, alanine, proline, hydroxyproline etc.
Object.It is small molecule natural moisturizing factor needed for skin, has preferable permeability, water imbibition, dissolubility and water-retaining property, right
The elasticity of skin, improves pachylosis state and maintenance dry skin cutin in excellent effect at wettability.
Yeast amino acid class of the invention is commercial product, commercially available.It is preferred that aiming at the original of cosmetic field producing and selling
Material.
Lack atelocollagen
The source of collagen has animal sources to extract and bioengineering preparation.Wherein, animal sources extraction mainly have ox, pig, fish or
Other aquatic products etc., but there is the risk for carrying animal sources germ virus.Bioengineering preparation is primarily referred to as by through biological work
The collagen of journey bacterium fermentation preparation output.
Collagen molecules are mutually wound by the polypeptide chain of three spirals and are constituted, and are N-terminal residue and C in its non-helical region
It holds residue, is the irregular alignment sequence of amino acid, is the end peptide of collagen (by taking type i collagen as an example, shown in Fig. 2).Pass through
Collagen molecules are carried out with certain manually modified, collagen being prepared after removal telopeptide region domain peptide sequence, referred to as
Atelocollagen lacks atelocollagen.
α-Gal antigenic content is reduced to detection limit hereinafter, by going end peptide method can be effective in Atelocollagen albumen
The immunogenicity for removing collagen shows to have passed through special immunogenicity removal technical process, Atelocollagen albumen material
The immunogenicity control of material is very excellent.And the triple-helix structure of collagen is not impacted in removal technique, preparation
Atelocollagen has high water absorption power, degradable characteristic, the feature of low immunogenicity and higher biocompatibility, can be greatly
The risk for causing allergy is reduced, while having certain promotion to water conservation, performance of keeping humidity.
Scarce atelocollagen of the invention is commercial product, commercially available.
Soluble collagen cross-linked polymer
Soluble collagen cross-linked polymer is to be drawn by cross-linking modified in collagen molecules with intermolecular with cross-linking method
The crosslinking for entering covalent bond obtains the polymer of super high molecular weight, forms a kind of fine and closely woven porous reticular structure of 3 D stereo.This at
Dtex point is, while retaining most of collagen structure, changes the single performance of ultimate constituent, improves protein fiber
The higher molecular weight polymer of the mechanical property and stability of dimension, formation has good resolvability, tension and bio-compatible
Property.Based on the considerations of collagenous source, artificial synthesized collagen preferably is prepared through biology, to prevent to extract collagen institute by animal origin
The animal pathogen of carrying guarantees the safety of material composition.
Applied in cosmetics, soluble collagen cross-linked polymer is overlying on skin surface, ventilative as special water storage water lock
Protective film, moisturizing that can be more long-acting, moisturizing greatly reduce the bored soapy feeling of conventional polymer moisturizer, are promoted and applied
The smooth experience sense of the slim and graceful water profit of rear skin, elasticity is smeared by improvement dermatoglyph enhances the barrier function and skin repair of skin
Ability.
Soluble collagen cross-linked polymer of the invention is commercial product, commercially available.
Main advantages of the present invention include:
1) present composition uses the active constituent of specific proportion, not only maintains the respective function of each active constituent,
And it can synergistically play a role.In addition, not only safety is good when the present composition is used for cosmetic use, also have anti-
Allergy and other effects.
2) present composition can be improved skin sophistication and glossiness, improve pachylosis, be drying, low and deep；
3) present composition skin care surface layer, a variety of small molecule aminoacid ingredient osmotic absorptions being rich in assign skin
Nutrition needed for skin；
4) present composition can effective oil-control while moisturizing water lock.
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In the following examples, the experimental methods for specific conditions are not specified, usually according to conventional strip
Part, such as Sambrook et al., molecular cloning: laboratory manual (New York:Cold Spring Harbor
Laboratory Press, 1989) condition described in, or according to the normal condition proposed by manufacturer.Unless otherwise stated, no
Then percentage and number are weight percent and parts by weight.
Embodiment 1.
The test of moisture-absorbing moisture-keeping performance
The processing of 1.1 samples
All samples are placed in vacuum oven (the upper macro experimental facilities Co., Ltd of Nereid, model: DZF-6050),
Drying goes water to constant weight under the conditions of 40 DEG C, and it is spare (loss on drying≤4%) to obtain powder sample.
1.2 wettability test
Sample is accurately weighed to two parts of 0.5g, being individually positioned in one has saturated ammonium sulfate solution (relative humidity 81%)
In the drier for having saturated sodium carbonate solution (relative humidity 43%) with one, standing time 3,6,12,24,36,48,
60,72h weighs sample quality respectively.Hydroscopicity calculation formula is as follows:
The experiment of 1.3 moisture retentions
[surveying moisture loss (volatilization) degree]
At room temperature, sample after 0.5g is dried accurately is weighed, sample is configured to aqueous specimen (the i.e. sample of water content 90%
Product: water=1:9), be placed in the drier equipped with dry silica gel (relative humidity 35% or so), standing time 3,6,12,24,
36,48,60,72h, weigh example weight respectively.Moisturizing rate calculation formula is as follows:
Moisturizing rate=(1- (moisture weight before moisture weight/placement after placement)) × 100% formula (2)
1.4 results:
1) saturated sodium carbonate solution sucting wet experiment data (relative humidity 43%)
Table 1
After 72 hours, compared with hyaluronic acid, the hygroscopicity of the present composition improves 30% or so, and contains only scarce end
Collagen, soluble collagen cross-linked polymer sample compare, the hygroscopicity of the present composition improves nearly 15%.
The result shows that the synergy of the present composition is best.
2) saturated ammonium sulfate solution sucting wet experiment data (relative humidity 81%)
Table 2
| Time | 0h | 3h | 6h | 12h | 24h | 36h | 48h | 60h | 72h |
| Tender skin conserves collagen | 0.00 | 6.47 | 10.76 | 15.45 | 20.56 | 24.08 | 26.78 | 28.59 | 30.27 |
| HA | 0.00 | 3.38 | 6.09 | 10.22 | 15.20 | 18.58 | 21.02 | 23.10 | 24.89 |
Compared with hyaluronic acid, the hygroscopicity of tender skin maintenance collagen of the invention improves 20% or so.
3) moisturizing rate:
Table 3
| Time | 0h | 3h | 6h | 9h | 12h | 24h | 36h | 48h | 60h | 72h |
| Tender skin conserves collagen | 0.00 | 78.03 | 63.34 | 56.74 | 56.74 | 53.64 | 49.19 | 47.44 | 45.28 | 43.4 |
| HA | 0.00 | 71.36 | 54.58 | 48.81 | 48.81 | 43.9 | 41.36 | 37.8 | 34.75 | 32.71 |
The result shows that especially at low relative humidity, the moisturizing of the present composition is inhaled compared with hyaluronic acid
Wet effect is more preferable.
Embodiment 2.
Tender skin maintenance facial mask test on probation
2.1 test product components:
Table 4
2.2 test method
It chooses the women of 7 unglazed allergies, the age without cosmetic allergic contact dermatitis history from 25 to 55 year old and does test object, everyone
Three veneer films are sent out, every night with a patch, once every three days, not wash one's face after having applied facial mask, Essence is massaged into absorption.Using face
Image analyzer SSA (the VisioFace face-image analyzer of CK (Courage&Khazaka) company of hardware Germany production,
Data Derm company of software Switzerland) analysis test is carried out to use process, analyze the exquisiteness for the front face skin that washes one's face every morning
With glossiness (facial pores and skin color difference degree of improvement).
2.3 results: the improvement amplitude using trier's corresponding index after product is calculated.Face-image analyzes result such as Fig. 1
It is shown.Related dermal parameter improvement rate is as shown in table 5:
Table 5
| People on probation | General pore area improvement rate | Big pore area improvement rate | Skin shine difference improvement rate | Skin colour difference improvement rate |
| Lee XX | 23.14% | - | 10.71% | 19.24% |
| Grandson XX | - | 14.44% | - | 6.42% |
| Grandson XX | 12.35% | 29.18% | 5.63% | 18.33% |
| Military XX | - | 3.42% | 13.74% | 12.29% |
| Open XX | 10.55% | - | 20.99% | 16.07% |
| Open XX | 3.08% | 48.33% | - | - |
| Zhu XX | 39.31% | - | 10.71% | - |
"-" is indicated without the data.
As can be seen from the above table: after facial mask uses three days, the general pore area of 71.43% trier is improved,
Middle maximum improvement rate is 39.31%；The big pore area of 85.71% trier is improved, wherein maximum improvement rate is
48.33%；The skin shine of 71.43% trier is improved, wherein maximum improvement rate is 20.99%；85.71% examination
The skin coloration of user is improved, wherein maximum improvement rate is 19.24%.
2.4 investigation on probation:
Table 6
Standards of grading:
It is fine: 9-10 points
It is preferable: 7-8 points
It is general: 5-6 points
It is poor: 3-4 points
Pore area is reduced well, improves skin shine the result shows that cosmetic composition of the invention has
Function can moisten moisturizing, it is fine and smooth make skin smooth, while having both good salubrious oil-control effect.
All references mentioned in the present invention is incorporated herein by reference, independent just as each document
It is incorporated as with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can
To make various changes or modifications to the present invention, such equivalent forms equally fall within model defined by the application the appended claims
It encloses.
Claims (10)
1. a kind of composition, which is characterized in that the composition contains:
(a) atelocollagen is lacked；
(b) soluble collagen cross-linked polymer；
(c) collagenous amino acids；
(d) lactoglobulin；With
(e) yeast tunning extract.
2. composition as described in claim 1, which is characterized in that the composition contains:
(a) 5-20 parts by weight, the preferably scarce atelocollagen of 10-15 parts by weight；
(b) 5-20 parts by weight, preferably the soluble collagen cross-linked polymer of 10-15 parts by weight；
(c) 1-5 parts by weight, preferably the collagenous amino acids of 3-5 parts by weight；
(d) 1-5 parts by weight, the preferably lactoglobulin of 3-5 parts by weight；
(e) 1-5 parts by weight, preferably the yeast tunning extract of 3-5 parts by weight；With
(f) excess water.
3. composition as described in claim 1, which is characterized in that the composition contains:
(a) 5-20%, the preferably scarce atelocollagen of 10-15%；
(b) 5-20%, preferably the soluble collagen cross-linked polymer of 10-15%；
(c) 1-5%, preferably the collagenous amino acids of 3-5%；
(d) 1-5%, the preferably lactoglobulin of 3-5%；
(e) 1-5%, preferably the yeast tunning extract of 3-5%；With
(f) excess water；
Wherein, the content is based on the total weight of the composition.
4. composition as described in claim 1, which is characterized in that the collagenous amino acids is selected from the group: glycine, silk ammonia
Acid, aspartic acid, alanine, proline, hydroxyproline, or combinations thereof.
5. the purposes of composition as described in claim 1, which is characterized in that be used to prepare cosmetics.
6. a kind of cosmetics, which is characterized in that the cosmetics contain (a) composition described in claim 1；(b) it makes up
Acceptable carrier or excipient in conduct and learning.
7. cosmetics as claimed in claim 6, which is characterized in that the cosmetics further include additional component selected from the group below:
Whitening or nti-freckle ingredient, anti-inflammatory component, antioxidant content, uvioresistant ingredient, or combinations thereof.
8. cosmetics as claimed in claim 6, which is characterized in that the dosage form of the cosmetics is solid dosage forms, semisolid agent
Type or liquid dosage form, such as solution, gel, cream, lotion, paste, creme, paste, cake, pulvis, patch.
9. cosmetics as claimed in claim 6, which is characterized in that it is described it is used for cosmetic in: tender skin maintenance, moisturizing, it is anti-inflammatory, shine
Afterwards repair, repair skin barrier, repair uv induction DNA damage, whitening, light spot, it is anti-saccharification, or combinations thereof.
10. a kind of method for preparing cosmetics as claimed in claim 6, which comprises the following steps:
(a) composition in claim 1 is provided；
(b) composition in step (a) is mixed with carrier acceptable on cosmeceutical, to obtain cosmetics.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112206306A (en) * | 2020-10-12 | 2021-01-12 | 广州艾玫格生物科技有限公司 | Biological anti-allergy compound |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102924731A (en) * | 2011-08-09 | 2013-02-13 | 双美生物科技股份有限公司 | Triple cross-linking collagen, preparation method and uses thereof |
| CN104921987A (en) * | 2015-06-02 | 2015-09-23 | 广州智媛生物科技有限公司 | Anti-aging essence containing triple collagen and preparation method of anti-aging essence |
| CN105596286A (en) * | 2016-01-25 | 2016-05-25 | 广州保税区雅兰国际化妆品有限公司 | Yeast skin-whitening cosmetic composition and preparation method thereof |
| KR20160126795A (en) * | 2015-04-24 | 2016-11-02 | 한국생산기술연구원 | Cosmetic materials and process for producing the same |
| KR20160126793A (en) * | 2015-04-24 | 2016-11-02 | 한국생산기술연구원 | Cosmetic materials and process for producing the same |
| CN106214597A (en) * | 2015-09-18 | 2016-12-14 | 广州十长生化妆品有限公司 | A kind of have lactalbumin frost making skin recovery elasticity and preparation method thereof |
| CN106999415A (en) * | 2014-10-14 | 2017-08-01 | Elc 管理有限责任公司 | Oil-control cosmetic powder |
| CN107233282A (en) * | 2017-06-20 | 2017-10-10 | 诺斯贝尔化妆品股份有限公司 | A kind of collagen, which compacts, lifts plentiful shining color face cream |
| CN108294999A (en) * | 2018-04-13 | 2018-07-20 | 李海珍 | A kind of composition and preparation method thereof for skin care |
-
2018
- 2018-10-10 CN CN201811178732.4A patent/CN109288745A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102924731A (en) * | 2011-08-09 | 2013-02-13 | 双美生物科技股份有限公司 | Triple cross-linking collagen, preparation method and uses thereof |
| CN106999415A (en) * | 2014-10-14 | 2017-08-01 | Elc 管理有限责任公司 | Oil-control cosmetic powder |
| KR20160126795A (en) * | 2015-04-24 | 2016-11-02 | 한국생산기술연구원 | Cosmetic materials and process for producing the same |
| KR20160126793A (en) * | 2015-04-24 | 2016-11-02 | 한국생산기술연구원 | Cosmetic materials and process for producing the same |
| CN104921987A (en) * | 2015-06-02 | 2015-09-23 | 广州智媛生物科技有限公司 | Anti-aging essence containing triple collagen and preparation method of anti-aging essence |
| CN106214597A (en) * | 2015-09-18 | 2016-12-14 | 广州十长生化妆品有限公司 | A kind of have lactalbumin frost making skin recovery elasticity and preparation method thereof |
| CN105596286A (en) * | 2016-01-25 | 2016-05-25 | 广州保税区雅兰国际化妆品有限公司 | Yeast skin-whitening cosmetic composition and preparation method thereof |
| CN107233282A (en) * | 2017-06-20 | 2017-10-10 | 诺斯贝尔化妆品股份有限公司 | A kind of collagen, which compacts, lifts plentiful shining color face cream |
| CN108294999A (en) * | 2018-04-13 | 2018-07-20 | 李海珍 | A kind of composition and preparation method thereof for skin care |
Non-Patent Citations (2)
| Title |
|---|
| 张何主编: "《实用美容药物》", 31 August 2016, 华中科技大学出版社 * |
| 赵丽主编: "《美容化妆品学》", 30 May 2005, 东北大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112206306A (en) * | 2020-10-12 | 2021-01-12 | 广州艾玫格生物科技有限公司 | Biological anti-allergy compound |
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