CN109287643A - Bactericidal composition and its application - Google Patents
Bactericidal composition and its application Download PDFInfo
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- CN109287643A CN109287643A CN201811251190.9A CN201811251190A CN109287643A CN 109287643 A CN109287643 A CN 109287643A CN 201811251190 A CN201811251190 A CN 201811251190A CN 109287643 A CN109287643 A CN 109287643A
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- thiophene
- bactericidal composition
- acid amide
- amine
- agent
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- MXMXHPPIGKYTAR-UHFFFAOYSA-N silthiofam Chemical compound CC=1SC([Si](C)(C)C)=C(C(=O)NCC=C)C=1C MXMXHPPIGKYTAR-UHFFFAOYSA-N 0.000 description 1
- HIEHAIZHJZLEPQ-UHFFFAOYSA-M sodium;naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 HIEHAIZHJZLEPQ-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 230000021918 systemic acquired resistance Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 150000004867 thiadiazoles Chemical class 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of microbicide compositions and its applications, belong to pesticide field, the bactericidal composition effective component is that first thiophene lures amine (A) and acid amide fungicides (B), it (A) is 1:30~40:1 with (B) weight ratio, preferable ratio is 1:15~20:1, and more preferable ratio is 1:7~10:1.Acid amide fungicides (B) can choose Boscalid, thifluzamide, furametpyr etc..The composition can add allow in other pesticides using auxiliary element be processed into any dosage form.The effect of the bactericidal composition is apparently higher than (A) and (B) single dose, with apparent synergistic effect, the amount of application of each single dose is effectively reduced, to expanding fungicidal spectrum and plant drug resistance being delayed to have preferable effect, tobacco virus, balck shank, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off etc. can be effectively prevented.
Description
The application be submit on 04 17th, 2014 application No. is 201410155202.3 (201611082145.6), hair
The divisional application of bright entitled " bactericidal composition and its application ".
Technical field
The present invention relates to a kind of bactericidal compositions, particularly relate to a kind of sterilization that amine and acid amide fungicides are lured containing first thiophene
Composition and its application.
Background technique
In agricultural production, crops can healthy growth, it is also very heavy to the prevention and treatment of disease in addition to being influenced by worm, crop smothering
It wants.Reinforcement and sustainable development implementation with environmental protection ideas, efficient, low toxicity, high activity, low-residual have become pesticide hair
The inexorable trend of exhibition.However, even efficient germicide, long-term exclusive use are also easy that disease is made to develop drug resistance, cause to use
The problems such as dose increases, preventive effect reduces, the lasting period shortens, is unfavorable for environment sustainable development.Therefore, how Scientific Usage of Drugs, drop
The dosage of low chemical pesticide improves drug effect, becomes plant protection art project urgently to be solved.
It is a kind of thiadiazoles that Lier Chemical Co., Ltd and Nankai University develop jointly that first thiophene, which lures amine (SZG),
Class plant disease-proof activator, general entitled N- (5- methyl-1,3- the thiazol-2-yl) -4- methyl-1 of chemistry, 2,3- thiadiazoles -5-
Formamide, structural formula is such as shown in (I).Current result of study shows that the compounds on viral disease has induction well
Disease resisting effect, mechanism of action are the anti-disease activity for inducing plant generation system, wide spectrum.Plant disease-proof activator be in recent years by
The novel pesticide of one kind of concern itself has no apparent bactericidal activity, but can induce and plant as the immunoactivator of plant
Object systemic acquired resistance, to achieve the purpose that defending and fighting against diseases.Wherein, BTH (diazosulfide, the production of Syngenta Co., Ltd of Switzerland)
It is the Representative Cultivars of such medicament with TDL (tiadinil, Nihon Nihyaku Co., Ltd's production), obtains in agricultural production at present
To widely applying.But it because first thiophene lures amine single dose unstable in variable rate technology, results in preventive effect and generates certain fluctuation, and is right
The plant to have fallen ill is without good therapeutic effect.
Acid amide fungicides occupy considerable status in world fungicide market, through true frequently as prevention and treatment Peronosporales
The special agent of bacterium has significant protection, treatment and eradicant action, is widely used in the prevention and treatment of plant disease.However, due to
Acid amide fungicides are single to germ effect, once germ mutates, medicament cannot normally play a role, thus lead to disease
Bacterium is also easy to produce drug resistance.Common acid amide fungicides kind in the market are as follows: dimethomorph, Boscalid, thifluzamide, furan pyrrole bacterium
Amine and metalaxyl etc..
Dimethomorph, structural formula is such as shown in (II).It is single-minded ovicidal Gammaproteobacteria fungal fungicide, action character is to destroy
The formation of cell envelope has effect to each stage of oomycetes history of life, outstanding in the formation stages of sporangiophore and egg spore
For sensitivity, (< 0.25 μ g/ml) is suppressed at much lower concentrations.Exclusive use have relatively high resistance risk, so often with
Protective fungicide is used in compounding, with the generation of delaying drug resistance.
Boscalid, structural formula is such as shown in (III).It is the novel nicotinamide sterilization by BASF Aktiengesellschaft's exploitation
Agent is mainly used for preventing and treating powdery mildew, gray mold, various rot diseases, brown rot and root rot etc., in 2004 in Britain, moral
State and Switzerland's registration.Boscalid belongs to succinic acid ubiquinone reductase inhibitor in mitochondrial respiratory chain, has to the sprouting of spore
Very strong rejection ability, and with other fungicide no interactions resistances.
Thifluzamide, structural formula is such as shown in (IV).It is a kind of succinate dehydrogenase inhibitor, i.e., in fungi tricarboxylic acids
Inhibit the synthesis of succinate dehydrogenase in circulation.It can prevent and treat caused by multiple diseases, especially basidiomycetes Rhizoctonia fungi
Disease, while there is very strong uptake and translocation.But to the disease as caused by leaf portion pathogen, such as the cercospora brown spot of peanut and black
Pinta effect is bad.
Furametpyr, structural formula is such as shown in (V).It is the novel amides developed by SUMITOMO CHEMICAL chemical industrial company
Fungicide.From 1989, the thoroughgoing and painstaking research of prevention and treatment banded sclerotial blight is carried out, the results showed that in laboratory and field with can
Wet powder, pulvis foliage application basin irrigation application prevention and treatment sheath and culm blight of rice preventive effect brilliance with granule.But due to using all the year round,
Crop has generated serious drug resistance to this, and the medicament lasting period is caused to shorten, and formulation rate increases, and control efficiency reduces.
Metalaxyl, structural formula is such as shown in (VI).It is the fungicide with three-dimensional optically active of first listing, can uses
In seed treatment, soil treatment and cauline leaf process.Be with protection therapeutic effect systemic fungicide, can by the root of plant,
Stem, leaf absorb, and are transferred to all parts of a plant with Dynamic water transport in plant.But due to using all the year round, crop is
Serious drug resistance has been generated to this, the medicament lasting period is caused to shorten, and formulation rate increases, and control efficiency reduces.
Frequent use containing single active ingredient fungicide causes most germs to produce drug resistance, and preventive effect is not
It is ideal.Therefore, it is badly in need of a kind of sterilised products of novel product substitution single active ingredient, increases the drug resistance that drug effect delays disease
Risk reduces economic loss.
Summary of the invention
For above situation, the present invention provides a kind of bactericidal composition, to meet the needs of agricultural production, institute in composition
The active component for including has mutually synergistic effect that can improve preventive effect and is beneficial to delay the generation of germ drug resistance.
In order to solve the above technical problems, the present invention provide technical solution it is as follows: bactericidal composition of the invention, effectively at
It is divided into first thiophene and lures amine and acid amide fungicides, it is 1:30~40:1 that first thiophene, which lures the weight ratio of amine and acid amide fungicides, preferably
Weight ratio is 1:15~20:1, and more preferably weight ratio is 1:7~10:1.
The acid amide fungicides can be fluopicolide, pyridine bacterium amine, Guardian, cyflufenamid, thiophene fluorine bacterium
In amine, zoxamide, fenhexamid, Silthiopham, dimethomorph, Boscalid, thifluzamide, furametpyr or metalaxyl
Any one.The present invention according to experiment effect, preferably dimethomorph, Boscalid, thifluzamide, furametpyr or metalaxyl into
Row compounding.
Auxiliary ingredients for pesticide preparations can also be contained in bactericidal composition of the present invention, be suitble to agriculturally use to be made
Dosage form.
It includes wetting agent, dispersing agent, emulsifier, solvent and filler that composition of the invention, which can also add auxiliary addition agent,
Deng and other be beneficial to the effective component known substance that stable and drug effect plays in the formulation, be all to be commonly used in pesticidal preparations or fair
Perhaps the various composition used has no specific restriction, has ingredient and dosage and is determined according to recipe requirements by simple experiment.
Bactericidal composition of the invention can be prepared into any one dosage form of suitable agricultural use by known method, than
Preferable dosage form is suspended emulsion (SE), wettable powder (WP), water dispersible granules (WDG), suspending agent (SC), dry suspending agent
(DF) etc..
A. solid raw medicine the preparation of suspended emulsion (suspoemulsiob, abbreviation SE): is reached into certain fineness by being sanded
It is added after liquid active compound, surfactant, solvent mix afterwards using mixing after the shearing of high shear dispersion machine.
B. wettable powder (WP) is solid powder preparation that in water can be evenly dispersed.Wettable powder of the present invention removes
Into raw medicine plus outside such as white carbon black, precipitated calcium carbonate, clay, diatomite, attapulgite diluent or inert substance, also
Ionic or nonionic surface active agent (wetting agent, dispersing agent), wetting agent is for example, alkylbenzene sulfonate (DBS-Na), alkane
Base naphthalene sulfonate (pull open powder), alkyl phenol polyoxyethylene ether sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfuric acid
Salt, aliphatic alcohol sulfate, fatty alcohol ethylene oxide adduct sulfonate, alkamide taurine salt, aliphatic alcohol polyethenoxy base
Ether (JFC), content 0.1~30%；Dispersing agent such as naphthalene sulfonate, naphthalene or alkyl naphthalene formaldehyde condensate sulfonate (NO, NN0, MF),
Lignin and its derivative sulfonate (M-9, POLYFON etc.), polyoxyethylene poly-oxygen propylene aether block copolymer, alkyl phenol polyoxy
Vinyl ethers formaldehyde condensation products sulfate (SOPA), PVA, CMC content 0.1~30%；Also contain penetrating agent JFC, azone, thiophene
One or more substances among ketone, penetrant t, content 0.3~30%；Stabilizer, foam inhibitor, anticaking agent can also be contained
Etc. other auxiliary agents.
C. water dispersible granules (WDG) is the granule that can be comparatively fast disintegrated in water, disperse to form higher suspension dispersion.
By active constituent, the elements such as the auxiliary agents such as wetting agent, dispersing agent, interleaving agent, disintegrating agent, stabilizer, adhesive and carrier composition.Its
The preparation method of auxiliary agent and carrier and precursor (preformed objects before granulation) is analogous to wettable powder and suspending agent substantially.
D. dry suspending agent (Dry Flowable, abbreviation DF) is comparatively fast to be disintegrated in water, disperse to form higher suspension dispersion
The granule of system.Preparation method: the preparation obtained by the dehydration of suspending agent.Its auxiliary agent and carrier and precursor (dehydration and drying
Preceding preformed objects) preparation method it is consistent with suspending agent.
E. suspending agent (SC) is not water soluble solid pesticide or immiscible liquids pesticide dispersion in water or oil.By living
Property ingredient, auxiliary agent (wetting dispersing agent, thickener, stabilizer, pH adjusting agent, defoaming agent, antifreezing agent) are through soybean dietary fiber system
?.Wetting dispersing agent can be naphthalene or alkyl naphthalene formaldehyde condensate sulfonate (NO, NN0, MF), lignin and its derivative sulfonic acid
Salt (M-9, POLYFON etc.), alkylphenol polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, alkane
Base phenol polyethenoxy base phosphate, carboxymethyl cellulose (CMC), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), condensation
One or more of phosphate etc., content 0.1~12%；Thickener and stabilizer can be xanthan gum (XG), polyethylene
One or more of alcohol (PVA), aluminum magnesium silicate etc., content 0.05~0.5%；PH adjusting agent and defoaming agent can be optionally appropriate
Addition.
Product described in the invention can be provided in the form of finished product preparation, i.e., each substance has mixed in compound, combination
The ingredient of object can also be provided with unit dose form, directly directly mixed, be then diluted to required in bucket or tank using preceding
Concentration.
Bactericidal composition of the invention can be used for preventing and treating plurality of plant diseases, be particularly suitable for prevention and treatment tobacco virus, black
The phytopathies such as shin disease, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off, the cercospora brown spot of peanut, black spot
Evil.Composition of the invention can be applied by common method, such as casting, injection, spraying, dusting or spread, amount of application with
Weather condition or crop condition variation.
Compared with prior art, the beneficial effects of the present invention are: 1, compared with single dose, there is compounding apparent collaboration to increase
Effect effect, improves control efficiency；2, composition is made of two kinds of different effective components of mechanism of action, is conducive to overcome and be prolonged
The generation of slow germ drug resistance；3, medicament mixture reduces dosage, to reduce costs and alleviate the pollution to environment；
4, not only effective to plant epiphyte crop disease, and anti-and treatment viral diseases of plants can be lured.The present invention is to tobacco virus, black
The virus diseases such as shin disease, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off, the cercospora brown spot of peanut, black spot
There is preferable control efficiency with bacterial fungus disease.
Specific embodiment
To keep the embodiment of the present invention technical problems to be solved, technical solution and advantage clearer, below by apparatus
Body embodiment is described in detail, but the present invention is limited to absolutely not these examples.The following is only the preferred embodiment of the present invention,
It is only used to explain the present invention, it cannot be construed as a limitation to the scope of the present invention.It should be pointed out that it is all
Any modifications, equivalent replacements, and improvements etc. done within the spirit and principles in the present invention, should be included in protection of the invention
Within the scope of.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Pesticide is made in the combination of active principles of different pesticides, is to develop and develop at present novel pesticide and prevention and treatment agriculturally
A kind of effective and quick way of resistance germ.After the pestsides synthesis of different cultivars, a large amount of three kinds of effects classes are typically exhibited
Type: summation action, synergistic effect and antagonism.Compound synergic is formulated well, can significantly improve practical control efficiency, drop
The usage amount of low pesticide is the important means of integrated control disease to help to delay the generation speed of germ drug resistance.
The present composition with first thiophene lure amine (A) be a kind of effective component, acid amide fungicides (B) be it is another effectively at
Point, it combines between them and plant epiphyte class disease and virus type disease is had obvious synergistic function, rather than just
The simple superposition of two kinds of pharmacy effects, this can be clearly understood that from following test result.
In order to prevent and treat the cucumber downy mildew in agricultural production, inventor lures amine and acid amide fungicides-alkene acyl with first thiophene
Quinoline or metalaxyl have carried out the synergy research of mutual compounding, method particularly includes:
Test uses downy mildew for test object.Raw medicine is configured to the test medicine needed, test method is with reference to " China
People's republic's agricultural industry criteria ".5 various concentration gradients are arranged (in preliminary experiment in single dose and each Mixed Pharmacy first
As a result on the basis of, difference is combined and matched according to different agents, concentration setting is also different, and bacteriostasis rate is 5%~90%
In the range of set).If clear water compares, it is repeated 3 times.Using half living body method (plate blade method), the Pseudoperonospora cubensis that will be prepared
Central vane is everywhither managed in spore liquid inoculation, is set after cultivating four days in 25 DEG C of constant temperature and humidity incubators；Check lesion diameter (cross
Interior extrapolation method), calculate the percentage that each processing inhibits scab growth, by the logarithm of the probit value of inhibiting rate and series of concentrations it
Between linear regression analysis, find out the EC50 value of each medicament, with co-toxicity coefficient meter calculate mixture co-toxicity coefficient (CTC), with
This evaluates reagent agent to the activity of germ.
()≤120 CTC show as synergistic effect to the co-toxicity coefficient of compound preparation；CTC≤80 show as antagonism；80<
CTC < 120 show as summation action.
1 first thiophene of table lures amine to compound the indoor harmacological effect measurement to cucumber downy mildew with dimethomorph
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Dimethomorph (B) | Y=1.7509+2.0479X | 38.6011 | —— |
| A:B=1:30 | Y=2.8009+1.5354X | 27.0529 | 143.39 |
| A:B=1:15 | Y=2.9474+1.5828X | 19.8187 | 196.65 |
| A:B=1:7 | Y=2.9509+1.6734X | 16.7708 | 234.64 |
| A:B=1:1 | Y=2.9690+1.7170X | 15.2371 | 274.24 |
| A:B=10:1 | Y=2.8132+1.6267X | 22.0934 | 202.83 |
| A:B=20:1 | Y=2.8010+1.5893X | 24.1912 | 186.67 |
| A:B=40:1 | Y=2.8009+1.5354X | 27.0529 | 167.62 |
2 first thiophene of table lures amine to compound the indoor toxicity test to cucumber downy mildew with metalaxyl
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Metalaxyl (F) | Y=2.2672+1.5501X | 57.9453 | —— |
| A:F=1:30 | Y=2.4845+1.5534X | 41.6248 | 137.99 |
| A:F=1:15 | Y=2.4753+1.5969X | 38.1095 | 149.51 |
| A:F=1:7 | Y=2.9400+1.5383X | 21.8358 | 256.63 |
| A:F=1:1 | Y=2.9711+1.5701X | 19.5965 | 260.26 |
| A:F=10:1 | Y=2.9794+1.4297X | 25.8997 | 179.34 |
| A:F=20:1 | Y=2.7247+1.5272X | 30.8931 | 148.95 |
| A:F=40:1 | Y=2.4394+1.6388X | 36.5165 | 125.38 |
The Toxicity Determination result shows that first thiophene lures amine and dimethomorph compounding, first thiophene that amine is lured to compound with metalaxyl to Huang
Melon downy mildew has apparent synergistic effect, and control efficiency is better than single dose kind.Inventor by test discovery, first thiophene lure amine with
Other acid amide fungicides (such as Boscalid, thifluzamide, furametpyr) compoundings, there is similar effect to cucumber downy mildew
Fruit.
In order to prevent and treat tomato late blight in agricultural production, inventor lures amine and acid amide fungicides-Boscalid with first thiophene
The synergy research of mutual compounding has been carried out, method particularly includes: test uses tomato late blight for test object.Raw medicine is configured to
The test medicine needed, test method refer to " People's Republic of China's agricultural industry criteria ".First by single dose and each mixed medicine
Agent is arranged 5 various concentration gradients and (on the basis of preliminary experiment result, different, concentration is combined and matched according to different agents
Setting is also different, and bacteriostasis rate is set in the range of 5%~90%).If clear water compares, it is repeated 3 times.Using pot-culture method,
It is inoculated with into each processing, is placed in 28 DEG C of constant temperature and humidity incubators and cultivates 4d；It checks lesion diameter (crossing method), calculates each
Processing inhibits the percentage of scab growth, passes through the linear regression between the probit value of inhibiting rate and the logarithm of series of concentrations point
Analysis, finds out the EC50 value of each medicament, and the co-toxicity coefficient (CTC) of mixture is calculated with co-toxicity coefficient meter, is evaluated with this for reagent
Activity of the agent to germ.
3 first thiophene of table lures amine to compound the indoor harmacological effect measurement to tomato late blight with Boscalid
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Boscalid (C) | Y=2.6278+1.5349X | 35.1207 | —— |
| A:C=1:30 | Y=2.9480+1.7181X | 15.6444 | 226.17 |
| A:C=1:15 | Y=3.0215+1.7140X | 14.2664 | 249.75 |
| A:C=1:7 | Y=3.1129+1.7219X | 12.4706 | 289.92 |
| A:C=1:1 | Y=3.2078+1.7559X | 10.4874 | 378.16 |
| A:C=10:1 | Y=2.8305+1.7827X | 16.4803 | 269.09 |
| A:C=20:1 | Y=2.8312+1.7346X | 17.7962 | 252.36 |
| A:C=40:1 | Y=2.8451+1.6902X | 18.8316 | 240.12 |
The Toxicity Determination result shows that first thiophene, which lures amine to compound with Boscalid, has apparent synergy to tomato late blight
Effect, control efficiency are better than single dose kind.Inventor lures amine and other acid amide fungicides (such as alkene by test discovery, first thiophene
Morpholide, thifluzamide, furametpyr, metalaxyl etc.) compounding, there is similar effect to tomato late blight.
In order to prevent and treat rice sheath blight disease in agricultural production, inventor lures amine and acid amide fungicides-furametpyr with first thiophene
The synergy research of mutual compounding has been carried out, method particularly includes: test uses banded sclerotial blight for test object.Raw medicine is configured to need
Test medicine, test method refer to " People's Republic of China's agricultural industry criteria ".Single dose and each Mixed Pharmacy are set first
It sets 5 various concentration gradients and (on the basis of preliminary experiment result, different, concentration setting is combined and matched according to different agents
Also different, bacteriostasis rate is set in the range of 5%~90%).If clear water compares, it is repeated 3 times.Using pot-culture method, to each
It is inoculated in processing, is placed in 28 DEG C~30 DEG C constant temperature and humidity incubators and cultivates 2d；It checks scab length, calculates each processing and inhibit disease
The percentage of spot growth is found out each by the linear regression analysis between the probit value of inhibiting rate and the logarithm of series of concentrations
The EC50 value of medicament calculates the co-toxicity coefficient (CTC) of mixture with co-toxicity coefficient meter, evaluates reagent agent to germ with this
Activity.
4 first thiophene of table lures amine to compound the indoor harmacological effect measurement to rice sheath blight disease with furametpyr
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Furametpyr (E) | Y=4.0225+0.6603X | 30.2333 | —— |
| A:E=1:30 | Y=4.1857+0.6617X | 17.0025 | 179.77 |
| A:E=1:15 | Y=4.2189+0.6590X | 15.3213 | 201.56 |
| A:E=1:7 | Y=4.2531+0.6699X | 13.0309 | 242.19 |
| A:E=1:1 | Y=4.2618+0.6771X | 12.3084 | 295.26 |
| A:E=10:1 | Y=4.2123+0.6684X | 15.0811 | 288.69 |
| A:E=20:1 | Y=4.0622+0.7110X | 20.8401 | 213.40 |
| A:E=40:1 | Y=3.9927+0.7084X | 26.4243 | 170.26 |
The Toxicity Determination result shows that first thiophene, which lures amine to compound with furametpyr, has apparent synergy to rice sheath blight disease
Effect, control efficiency are better than single dose kind.Inventor lures amine and other acid amide fungicides (such as alkene by test discovery, first thiophene
Morpholide, Boscalid, thifluzamide, metalaxyl etc.) compounding, there is similar effect to rice sheath blight disease.
In order to prevent and treat tobacco virus in agricultural production, inventor lures amine and acid amide fungicides-thifluzamide with first thiophene
The synergy research of mutual compounding has been carried out, method particularly includes: test uses tobacco virus for test object.Raw medicine is configured to
The test medicine needed, test method refer to " People's Republic of China's agricultural industry criteria ".First by single dose and each mixed medicine
Agent is arranged 5 various concentration gradients and (on the basis of preliminary experiment result, different, concentration is combined and matched according to different agents
Setting is also different, and bacteriostasis rate is set in the range of 5%~90%).If clear water compares, it is repeated 3 times.Using pot-culture method,
It is inoculated with tobacco virus into each processing, is placed in 28 DEG C~30 DEG C constant temperature and humidity incubators and cultivates 5d；Check each processing inoculation leaf
The morbidity scab number of on piece calculates the percentage that each processing inhibits scab growth, passes through the probit value and series of concentrations of inhibiting rate
Logarithm between linear regression analysis, find out the EC50 value of each medicament, with co-toxicity coefficient meter calculate mixture it is total poison be
Number (CTC) evaluates reagent agent to the activity of germ with this.
5 first thiophene of table lures amine to compound the indoor harmacological effect measurement to virosis with thiophene fluorine bacterium amine
The Toxicity Determination result shows that first thiophene, which lures amine to compound with thiophene fluorine bacterium amine, has apparent synergy to tobacco virus
Effect, control efficiency are better than single dose kind.Inventor lures amine and other acid amide fungicides (such as alkene by test discovery, first thiophene
Morpholide, Boscalid, furametpyr, metalaxyl etc.) compounding, there is similar effect to tobacco virus.
Bactericidal composition of the invention can be prepared into any one dosage form of suitable agricultural use by known method, than
Preferable dosage form is wettable powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.It is right with reference to embodiments
The content of present invention is described further, and percentage is weight percentage in all formulas.The various dosage forms of the present composition
Processing technology is the prior art, can be varied according to different situations.
Embodiment 1:32% first thiophene lures amine furametpyr suspending agent
2% first thiophene is weighed respectively lures amine, 30% furametpyr, 4% sodium polycarboxylate, 3% fatty alcohol polyoxyethylene ether, 6%
Ethylene glycol, 0.35%XG, 0.6% organic silicon defoamer, 0.4% sodium benzoate, deionized water add to 100% parts by weight.It will be each
Component mixing, is uniformly mixed through high speed shear, then is sanded 2-3 hours by sand mill, reaches 1-5 microns of fineness to get 32%
First thiophene lures amine furametpyr suspending agent.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
Embodiment 2:30% first thiophene lures amine furametpyr suspending agent
15% first thiophene is weighed respectively lures amine, 15% furametpyr, 4% sodium naphthalene sulfonate, 2% Nonyl pheno phosphoric acid
Ester, 6% ethylene glycol, 0.30%XG, 0.6% organic silicon defoamer, 0.4% sodium benzoate, deionized water add to 100% weight
Part.Each component is mixed, is uniformly mixed through high speed shear, then is sanded 2-3 hours by sand mill, reaches 1-5 microns of fineness, i.e.,
It obtains 30% first thiophene and lures amine furametpyr suspending agent.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
The first thiophene of embodiment 3:22% lures amine furametpyr suspended emulsion
Weigh 2% furametpyr, 3% phosphoric acid ester APEO, 2% nonylphenol polyoxyethylene ether, 10% C9 aromatic
Solvent, is mixed evenly spare, weighs 20% first thiophene and lures amine, 2% phosphoric acid ester APEO, 6% ethylene glycol, and 0.25%
XG, 0.6% organic silicon defoamer, 0.4% sodium benzoate, deionized water add to 100% parts by weight.Reach fineness 1- by being sanded
The furametpyr solution prepared is added after 4 microns can be prepared by 22% first using mixing after high shear dispersion machine shearing 30min
Thiophene lures amine furametpyr suspended emulsion.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
Embodiment 4:46.5% first thiophene lures amine furametpyr suspending agent
1.5% first thiophene is weighed respectively lures amine, 45% furametpyr, 4% sodium polycarboxylate, 3% fatty alcohol polyoxyethylene ether,
6% ethylene glycol, 0.35%XG, 0.6% organic silicon defoamer, 0.4% sodium benzoate, deionized water add to 100% parts by weight.It will
Each component mixing, was uniformly mixed through high speed shear, then by sand mill sand milling 2-3 hours, reach 1-5 microns of fineness to get
46.5% first thiophene lures amine furametpyr suspending agent.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
Embodiment 5:24% first thiophene lures amine dimethomorph water dispersion granula
It weighs 3% first thiophene and lures amine, 21% dimethomorph, 5% lauryl sodium sulfate, 5% dodecyl sodium sulfate, 2%
Modified lignin resin, 2% calcium chloride, kaolin complement to 100% parts by weight.Each component is mixed, is mechanically pulverized, then through air-flow
It crushes, is uniformly mixed, then through wet granulation and dry and to get 24% first thiophene lure amine dimethomorph water dispersion granula.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
The first thiophene of embodiment 6:31.5% lures amine dimethomorph suspended emulsion
Weigh 1.5% dimethomorph, 3% phosphoric acid ester APEO, 2% nonylphenol polyoxyethylene ether, 8% C9 aromatic
Solvent, is mixed evenly spare, weighs 30% first thiophene and lures amine, 3% phosphoric acid ester APEO, 6% ethylene glycol, and 0.25%
XG, 0.6% organic silicon defoamer, 0.4% sodium benzoate, deionized water add to 100% parts by weight.Reach fineness 1- by being sanded
Mixing after the dimethomorph solution prepared shears 30min using high shear dispersion machine is added after 4 microns can be prepared by 31.5%
First thiophene lures amine dimethomorph suspended emulsion.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
Embodiment 7:30% first thiophene lures amine dimethomorph wettable powder
Weigh 15% first thiophene and lure amine, 15% dimethomorph, 7% modified lignin resin, 3% polyoxyethylene ether formaldehyde condensation products,
5% white carbon black, kaolin complement to 100% parts by weight；Each component is mixed, is mechanically pulverized, then through air-flow crushing, mixing is equal
It is even to lure amine dimethomorph wettable powder to get 30% first thiophene.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, thiophene fluorine
Amide, metalaxyl etc.), to form new embodiment.
Embodiment 8:41% first thiophene lures amine thifluzamide water dispersible granules
It weighs 1% first thiophene and lures amine, 40% thifluzamide, 5% lauryl sodium sulfate, 5% dodecyl sodium sulfate, 2%
Modified lignin resin, 2% calcium chloride, kaolin complement to 100% parts by weight.Each component is mixed, is mechanically pulverized, then through air-flow
It crushes, is uniformly mixed, then through wet granulation and dry and to get 41% first thiophene lure amine thifluzamide water dispersible granules.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, first frost
Spirit etc.), to form new embodiment.
The first thiophene of embodiment 9:31% lures amine thifluzamide suspended emulsion
Weigh 1% thifluzamide, 3% phosphoric acid ester APEO, 2% nonylphenol polyoxyethylene ether, 8% C9 aromatic is molten
Agent, is mixed evenly spare, weighs 30% first thiophene and lures amine, 3% phosphoric acid ester APEO, 6% ethylene glycol, 0.25%XG,
0.6% organic silicon defoamer, 0.4% sodium benzoate, deionized water add to 100% parts by weight.It is micro- to reach fineness 1-4 by sand milling
The dimethomorph solution prepared is added after rice to lure using the first thiophene that can be prepared by 31% is mixed after high shear dispersion machine shearing 30min
Amine thifluzamide suspended emulsion.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, first frost
Spirit etc.), to form new embodiment.
The pesticidal preparations made from above-described embodiment prevent and treat rice sheath blight disease test:
1, test process: test is carried out referring to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
It tests dosing and three concentration for the treatment of is set according to the difference of each ingredient respectively.Comparison medicament is commercially available 25% first thiophene of pesticide respectively
Lure amine and 15% furametpyr WP and blank clean water experiment.
2, test method: each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and prevent and treat before being administered
Method are as follows: every cell diagonal line takes a little, and every is extracted 10 clumps of investigation.Test result see the table below 6:
6 first thiophene of table lures amine and furametpyr to compound the control efficiency to rice sheath blight disease
Field efficacy the result shows that, first thiophene, which lures amine and furametpyr to compound, there is excellent prevention and treatment to imitate rice sheath blight disease
Fruit, control efficiency are better than single dose kind.
The pesticidal preparations made from above-described embodiment prevent and treat tobacco black shank test: 1, test process: test is referring to China
People's republic's standard (pesticide field efficacy medicine test criterion)
It carries out.This test medicine dosage sets three concentration for the treatment of, comparison medicament difference according to the difference of each ingredient respectively
It is that commercially available 25% first thiophene of pesticide lures amine and 50% dimethomorph WG and blank clean water experiment.
2, test method: each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and prevent and treat before being administered
Method are as follows: every cell diagonal line sampling often clicks 10 plants.The percentage of entire stem area is accounted for the lesion area on every plant of whole strain stem
It is classified, test result see the table below 7:
7 first thiophene of table lures amine and dimethomorph to compound the control efficiency to tobacco black shank
Field efficacy the result shows that, first thiophene, which lures amine and dimethomorph to compound, also has excellent prevention and treatment effect to tobacco black shank
Fruit, control efficiency are better than single dose kind.
The pesticidal preparations made from above-described embodiment prevent and treat cucumber downy mildew test: 1, test process: test is referring to China
People's republic's standard (pesticide field efficacy medicine test criterion) carries out.This test medicine dosage is distinguished according to the difference of each ingredient
If three concentration for the treatment of, comparison medicament is that commercially available 25% first thiophene of pesticide lures amine and 50% dimethomorph WG and blank clear water to try respectively
It tests.
2, test method: each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and prevent and treat before being administered
Method are as follows: every cell diagonal line sampling often clicks 10 plants.The percentage of entire leaf area is accounted for the lesion area on every plant of one-piece blade
It is classified, test result see the table below 8:
8 first thiophene of table lures amine and dimethomorph to compound the control efficiency to cucumber downy mildew
Field efficacy the result shows that, first thiophene, which lures amine and dimethomorph to compound, also has excellent prevention and treatment effect to cucumber downy mildew
Fruit, control efficiency are better than single dose kind.
The pesticidal preparations made from above-described embodiment prevent and treat tobacco virus test: 1, test process: test is referring to China
People's republic's standard (pesticide field efficacy medicine test criterion) carries out.This test medicine dosage is distinguished according to the difference of each ingredient
If three concentration for the treatment of, comparison medicament is that commercially available 25% first thiophene of pesticide lures amine and 24% thifluzamide SC and blank clear water to try respectively
It tests.
2, test method: each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and prevent and treat before being administered
Method are as follows: every cell diagonal line sampling often clicks 10 plants.The percentage of entire stem area is accounted for the lesion area on every plant of whole strain stem
It is classified, test result see the table below 7:
9 first thiophene of table lures amine and thifluzamide to compound the control efficiency to tobacco virus
Field efficacy the result shows that, first thiophene, which lures amine and thifluzamide to compound, also has excellent prevention and treatment effect to tobacco virus
Fruit, control efficiency are better than single dose kind.
Claims (8)
1. a kind of bactericidal composition, it is characterised in that: lure amine and acid amide fungicides to form by first thiophene, the acid amide fungicides
For thifluzamide, it is 1:30~40:1 that the first thiophene, which lures the weight ratio of amine and acid amide fungicides,.
2. bactericidal composition according to claim 1, it is characterised in that: the first thiophene lures the weight of amine and acid amide fungicides
Amount is than being 1:15~20:1.
3. bactericidal composition according to claim 1, it is characterised in that: the first thiophene lures the weight of amine and acid amide fungicides
Amount is than being 1:7~10:1.
4. bactericidal composition according to any one of claims 1 to 3, it is characterised in that: also contain in the bactericidal composition
There is auxiliary ingredients for pesticide preparations, the dosage form for being suitble to agriculturally use is made.
5. bactericidal composition according to claim 4, it is characterised in that: the auxiliary ingredients for pesticide preparations is solvent, cream
One or more of agent, dispersing agent, stabilizer, antifreezing agent or wetting agent.
6. bactericidal composition according to claim 5, it is characterised in that: the dosage form of the bactericidal composition is wettable powder
Agent, suspended emulsion, water dispersion granule, suspending agent or dry suspending agent.
7. the application of bactericidal composition described in claim 1, it is characterised in that: be used for controlling plant diseases.
8. the application of bactericidal composition according to claim 7, it is characterised in that: for preventing and treating tobacco virus, black shin
Disease, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off, the cercospora brown spot of peanut, black spot.
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| CN201811251190.9A CN109287643B (en) | 2014-04-17 | 2014-04-17 | Bactericidal composition and application thereof |
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| CN201811251190.9A CN109287643B (en) | 2014-04-17 | 2014-04-17 | Bactericidal composition and application thereof |
| CN201410155202.3A CN105010358B (en) | 2014-04-17 | 2014-04-17 | Bactericidal composition and application thereof |
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| CN201811251190.9A Expired - Fee Related CN109287643B (en) | 2014-04-17 | 2014-04-17 | Bactericidal composition and application thereof |
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| CN105191950B (en) * | 2014-05-30 | 2017-07-14 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN106614642B (en) * | 2015-11-02 | 2020-04-21 | 四川利尔作物科学有限公司 | Seed treatment agent composition and application thereof |
| CN107801724A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN107801721A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN108094431A (en) * | 2016-11-24 | 2018-06-01 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN109122701A (en) * | 2017-06-16 | 2019-01-04 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
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Also Published As
| Publication number | Publication date |
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| CN109287643B (en) | 2021-04-16 |
| CN109452292A (en) | 2019-03-12 |
| CN106719711A (en) | 2017-05-31 |
| CN106719711B (en) | 2020-07-10 |
| CN109452292B (en) | 2021-04-16 |
| CN105010358A (en) | 2015-11-04 |
| CN105010358B (en) | 2017-05-17 |
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