CN109276486A - A kind of compound and preparation method thereof of the yeast extractive from fermentative of moisturizing anti-aging - Google Patents
A kind of compound and preparation method thereof of the yeast extractive from fermentative of moisturizing anti-aging Download PDFInfo
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- CN109276486A CN109276486A CN201811203842.1A CN201811203842A CN109276486A CN 109276486 A CN109276486 A CN 109276486A CN 201811203842 A CN201811203842 A CN 201811203842A CN 109276486 A CN109276486 A CN 109276486A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of compoiste fermented object and preparation method thereof with moisturizing senile-resistant efficacy, the compoiste fermented object consists of the following compositions: yeast tunning extract, saccharomycete river paddy seed tunning filtrate, surplus is saccharomycete laminariose tunning, it is 20%-30% that wherein yeast tunning extract, which accounts for composition total weight proportion, it is 20%-30% that saccharomycete river paddy seed tunning filtrate, which accounts for composition total weight proportion, surplus is saccharomycete laminariose tunning, the present invention uses microbial fermentation technology, by river paddy seed extract, skin absorbs difficult macromolecular active principle progress biological decomposition in Thallus Laminariae (Thallus Eckloniae) extract, it makes it easier for being less readily available for absorption by the skin, to more effectively play the role of moisturizing anti-aging, using biofermentation technique, easily absorb, it is non-stimulated, meet people to cosmetics The requirement of safety and effectiveness, has a extensive future.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to a kind of compoiste fermented object with moisturizing senile-resistant efficacy and
Preparation method.
Background technique
Aging is a lasting change procedure, and international mainstream thinks radical damage human body cell, so as to cause numerous
Disease accelerates human senility.Free radical is quenched from being generated to, profoundly affect the formation of lipofuscin, the mutation of mitochondrial DNA,
Induce cell apoptosis the synthesis with protein, the relationship between free radical and aging, free radical can caused by disease, to propose
How to delay senescence, slows down itself aging for the mankind and provide certain scientific basis.
Anti-aging, which does not refer to, allows people to increase the service life, but to human body because of the continuous contact with the external world, including breathing
(oxidation reaction), outside contamination, radioactive ray irradiation etc. factors constantly generated free radicals in body caused by have the allotted portion of life reduced by having or getting more than one deserves because
Element.
Anti-oxidant is clearly the popular character of beauty circle in recent years.Why need it is anti-oxidant because ultraviolet light is seeping
After entering skin, harmful free radical can be generated, these free radicals can destroy elastic fibers of skin, and stimulation melanin cell, which increases, to be divided
It secretes, so as to cause dry skin relaxation, accelerates aging.So needing to help to reduce free radical by supplement antioxidant
It generates.
Yeast extract derives from unartificial yeast, and amino acid, peptide, nucleotide, vitamin rich in small molecule etc. are naturally living
Property ingredient.Amino acid is conducive to the synthesis of collagen, and the skin of aging can be made to restore elasticity, delay skin aging;Nucleic acid and
Nucleotide has the effects that boost metabolism, improves protein aggregate velocity, can enhance immunity function, improve the anti-freedom of skin
Base ability;Various oligopeptides constituents can be used as signaling molecule, participates in and tyrosinase competes, to inhibit the life of melanin
At.
River paddy seed extract has moderate inoxidizability, can increase skin activity, reduces wrinkle, has centainly
Anti-aging effects.River paddy seed extract is fermented with saccharomycete, makes the work in fermentation liquid both containing river paddy seed extract
Property substance, and with yeast tunning extract senile-resistant efficacy, the two serves in terms of anti-aging to be collectively promoted.
Plant polyose is with preferable moistening effect, but since its molecular weight is larger, it is more difficult to be absorbed by the skin, utilize ferment
Female bacterium decomposes the polysaccharide in thallus laminariae, makes it easier for being absorbed by human skin, to achieve the effect that moisturizing anti-aging.
Summary of the invention
The purpose of the present invention is to provide a kind of compoiste fermented object and preparation method thereof with moisturizing senile-resistant efficacy.
The technical solution adopted by the present invention is that:
A kind of compound of the yeast extractive from fermentative of moisturizing anti-aging, it is characterised in that: the compoiste fermented object is by following component
Composition: yeast tunning extract, saccharomycete river paddy seed tunning filtrate, surplus are saccharomycete laminariose tunning,
It is 20%-30% that wherein yeast tunning extract, which accounts for composition total weight proportion, and saccharomycete river paddy seed tunning filtrate accounts for
Composition total weight proportion is 20%-30%, and surplus is saccharomycete laminariose tunning.
A kind of preparation method of the compoiste fermented object with moisturizing senile-resistant efficacy, characterized by the following steps:
30 DEG C of activated yeast of step 1:YM culture medium (no agar) are cultivated 2 days, are accessed to 20kgYM culture medium (no agar)
The constant-temperature table culture 2 days of 30 DEG C of 0.2-0.4kg activated yeast obtains saccharomycetes to make fermentation liquid, and 0.1-0.3%NaCl self-dissolving 24- is added
30h, filtering and impurity removing remove cell wall and insoluble molecule, and 70 DEG C of vacuum distillations remove ethyl alcohol, obtain the extraction of yeast tunning
Object；
Step 2: river paddy seed being cleaned up, is crushed, 30-40 DEG C of ultrasonic extraction 20-40min of 10-15 times of pure water is added, filters at a slow speed
Paper filtering, obtains river paddy seed extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no fine jade after sterilizing
Rouge) 30 DEG C of activated yeast cultivate 3 days, to 20kg sterilized cooling river paddy seed extracting solution access 0.2-0.4kg activated yeast
The constant-temperature table culture 2 days of 30 DEG C of bacterium obtains saccharomycete river paddy seed tunning, and 0.1-0.3%NaCl self-dissolving 24-30h, filtering is added
Removal of impurities removal cell wall and insoluble molecule, remove ethyl alcohol, obtain saccharomycete river paddy seed tunning filtrate；
Step 3: thallus laminariae being cleaned up, is shredded, 70-90 DEG C of water-bath 2-3h of 10-15 times of pure water is added, slow filter paper filtering obtains
Laminariose extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no agar) activated yeast after sterilizing
30 DEG C of bacterium cultivate 3 days, to 20kg sterilized cooling laminariose extracting solution access 30 DEG C of constant temperature of 0.2-0.4kg activated yeast shake
Bed culture 2 days, obtains saccharomycete laminariose tunning, and 0.1-0.3%NaCl self-dissolving 24-30h is added, and filtering and impurity removing removes cell
Wall and insoluble molecule remove ethyl alcohol, obtain saccharomycete laminariose tunning；
Step 4: yeast tunning extract, saccharomycete river paddy seed tunning filtrate and saccharomycete prepared by step 1-3
Laminariose tunning adds by a certain percentage, and dissolution is fitted into the bottle sterilized after mixing.
Advantages of the present invention: using microbial fermentation technology, skin in river paddy seed extract, Thallus Laminariae (Thallus Eckloniae) extract is absorbed tired
Difficult macromolecular active principle carries out biological decomposition, makes it easier for being less readily available for absorption by the skin, so that it is anti-more effectively to play moisturizing
The effect of aging is easily absorbed using biofermentation technique, non-stimulated, is met requirement of the people to cosmetics safety validity, is answered
With having a extensive future.
Specific embodiment
Embodiment 1
A kind of compound of the yeast extractive from fermentative of moisturizing anti-aging, the compoiste fermented object consist of the following compositions: yeast hair
Ferment product extract, saccharomycete river paddy seed tunning filtrate, surplus are saccharomycete laminariose tunning, and wherein yeast ferments
It is 20% that product extract, which accounts for composition total weight proportion, and saccharomycete river paddy seed tunning filtrate accounts for composition total weight proportion
It is 20%, surplus is saccharomycete laminariose tunning.
A kind of preparation method of the compoiste fermented object with moisturizing senile-resistant efficacy, includes the following steps:
30 DEG C of activated yeast of step 1:YM culture medium (no agar) are cultivated 2 days, are accessed to 20kgYM culture medium (no agar)
The constant-temperature table culture 2 days of 30 DEG C of 0.2kg activated yeast obtains saccharomycetes to make fermentation liquid, and 0.1%NaCl self-dissolving is added for 24 hours, crosses and filters out
Miscellaneous removal cell wall and insoluble molecule, 70 DEG C of vacuum distillations remove ethyl alcohol, obtain yeast tunning extract；
Step 2: river paddy seed being cleaned up, is crushed, 10 times of pure water, 30 DEG C of ultrasonic extraction 20min are added, slow filter paper filtering obtains
River paddy seed extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no agar) activated yeast after sterilizing
30 DEG C of bacterium are cultivated 3 days, have been sterilized river paddy seed extracting solution access 0.2kg activated yeast 30 DEG C of constant-temperature tables training of cooling to 20kg
It supports 2 days, obtains saccharomycete river paddy seed tunning, 0.1%NaCl self-dissolving is added for 24 hours, filtering and impurity removing removes cell wall and insoluble point
Son removes ethyl alcohol, obtains saccharomycete river paddy seed tunning filtrate；
Step 3: thallus laminariae being cleaned up, is shredded, 10 times of pure water, 70 DEG C of water-bath 2h are added, slow filter paper filtering obtains laminariose and mentions
Liquid is taken, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, 30 DEG C of activated yeast of YM culture medium (no agar) trainings after sterilizing
Support 3 days, to 20kg sterilized cooling laminariose extracting solution access the constant-temperature table culture 2 days of 30 DEG C of 0.2kg activated yeast, obtain
0.1%NaCl self-dissolving is added for 24 hours in saccharomycete laminariose tunning, and filtering and impurity removing removes cell wall and insoluble molecule, removal
Ethyl alcohol obtains saccharomycete laminariose tunning；
Step 4: yeast tunning extract, saccharomycete river paddy seed tunning filtrate and saccharomycete prepared by step 1-3
Laminariose tunning adds by a certain percentage, and dissolution is fitted into the bottle sterilized after mixing.
The present invention uses microbial fermentation technology, and skin in river paddy seed extract, Thallus Laminariae (Thallus Eckloniae) extract is absorbed the big of difficulty
Molecule active principle carries out biological decomposition, makes it easier for being less readily available for absorption by the skin, to more effectively play moisturizing anti-aging
Effect is easily absorbed using biofermentation technique, non-stimulated, meets requirement of the people to cosmetics safety validity, application prospect
It is wide.
Embodiment 2
A kind of compound of the yeast extractive from fermentative of moisturizing anti-aging, it is characterised in that: the compoiste fermented object is by following component
Composition: yeast tunning extract, saccharomycete river paddy seed tunning filtrate, surplus are saccharomycete laminariose tunning,
It is 30% that wherein yeast tunning extract, which accounts for composition total weight proportion, and saccharomycete river paddy seed tunning filtrate accounts for combination
Object total weight proportion is 30%, and surplus is saccharomycete laminariose tunning.
A kind of preparation method of the compoiste fermented object with moisturizing senile-resistant efficacy, includes the following steps:
30 DEG C of activated yeast of step 1:YM culture medium (no agar) are cultivated 2 days, are accessed to 20kgYM culture medium (no agar)
The constant-temperature table culture 2 days of 30 DEG C of 0.4kg activated yeast obtains saccharomycetes to make fermentation liquid, and 0.3%NaCl self-dissolving 30h is added, and crosses and filters out
Miscellaneous removal cell wall and insoluble molecule, 70 DEG C of vacuum distillations remove ethyl alcohol, obtain yeast tunning extract；
Step 2: river paddy seed being cleaned up, is crushed, 15 times of pure water, 40 DEG C of ultrasonic extraction 40min are added, slow filter paper filtering obtains
River paddy seed extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no agar) activated yeast after sterilizing
30 DEG C of bacterium are cultivated 3 days, have been sterilized river paddy seed extracting solution access 0.4kg activated yeast 30 DEG C of constant-temperature tables training of cooling to 20kg
It supports 2 days, obtains saccharomycete river paddy seed tunning, 0.3%NaCl self-dissolving 30h is added, filtering and impurity removing removes cell wall and insoluble point
Son removes ethyl alcohol, obtains saccharomycete river paddy seed tunning filtrate；
Step 3: thallus laminariae being cleaned up, is shredded, 15 times of pure water, 90 DEG C of water-bath 3h are added, slow filter paper filtering obtains laminariose and mentions
Liquid is taken, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, 30 DEG C of activated yeast of YM culture medium (no agar) trainings after sterilizing
Support 3 days, to 20kg sterilized cooling laminariose extracting solution access the constant-temperature table culture 2 days of 30 DEG C of 0.4kg activated yeast, obtain
Saccharomycete laminariose tunning, is added 0.3%NaCl self-dissolving 30h, and filtering and impurity removing removes cell wall and insoluble molecule, removal
Ethyl alcohol obtains saccharomycete laminariose tunning；
Step 4: yeast tunning extract, saccharomycete river paddy seed tunning filtrate and saccharomycete prepared by step 1-3
Laminariose tunning adds by a certain percentage, and dissolution is fitted into the bottle sterilized after mixing.
The present invention uses microbial fermentation technology, and skin in river paddy seed extract, Thallus Laminariae (Thallus Eckloniae) extract is absorbed the big of difficulty
Molecule active principle carries out biological decomposition, makes it easier for being less readily available for absorption by the skin, to more effectively play moisturizing anti-aging
Effect is easily absorbed using biofermentation technique, non-stimulated, meets requirement of the people to cosmetics safety validity, application prospect
It is wide.
Embodiment 3
A kind of compound of the yeast extractive from fermentative of moisturizing anti-aging, it is characterised in that: the compoiste fermented object is by following component
Composition: yeast tunning extract, saccharomycete river paddy seed tunning filtrate, surplus are saccharomycete laminariose tunning,
It is 25% that wherein yeast tunning extract, which accounts for composition total weight proportion, and saccharomycete river paddy seed tunning filtrate accounts for combination
Object total weight proportion is 25%, and surplus is saccharomycete laminariose tunning.
A kind of preparation method of the compoiste fermented object with moisturizing senile-resistant efficacy, includes the following steps:
30 DEG C of activated yeast of step 1:YM culture medium (no agar) are cultivated 2 days, are accessed to 20kgYM culture medium (no agar)
The constant-temperature table culture 2 days of 30 DEG C of 0.3kg activated yeast obtains saccharomycetes to make fermentation liquid, and 0.2%NaCl self-dissolving 27h is added, and crosses and filters out
Miscellaneous removal cell wall and insoluble molecule, 70 DEG C of vacuum distillations remove ethyl alcohol, obtain yeast tunning extract；
Step 2: river paddy seed being cleaned up, is crushed, 12 times of pure water, 35 DEG C of ultrasonic extraction 30min are added, slow filter paper filtering obtains
River paddy seed extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no agar) activated yeast after sterilizing
30 DEG C of bacterium are cultivated 3 days, have been sterilized river paddy seed extracting solution access 0.3kg activated yeast 30 DEG C of constant-temperature tables training of cooling to 20kg
It supports 2 days, obtains saccharomycete river paddy seed tunning, 0.2%NaCl self-dissolving 27h is added, filtering and impurity removing removes cell wall and insoluble point
Son removes ethyl alcohol, obtains saccharomycete river paddy seed tunning filtrate；
Step 3: thallus laminariae being cleaned up, is shredded, 12 times of pure water, 80 DEG C of water-bath 2.5h are added, slow filter paper filtering obtains laminariose
Extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, 30 DEG C of activated yeast of YM culture medium (no agar) after sterilizing
Culture 3 days, to 20kg sterilized cooling laminariose extracting solution access the constant-temperature table culture 2 days of 30 DEG C of 0.3kg activated yeast,
Saccharomycete laminariose tunning is obtained, 0.2%NaCl self-dissolving 27h is added, filtering and impurity removing removes cell wall and insoluble molecule, goes
Except ethyl alcohol, saccharomycete laminariose tunning is obtained；
Step 4: yeast tunning extract, saccharomycete river paddy seed tunning filtrate and saccharomycete prepared by step 1-3
Laminariose tunning adds by a certain percentage, and dissolution is fitted into the bottle sterilized after mixing.
The present invention uses microbial fermentation technology, and skin in river paddy seed extract, Thallus Laminariae (Thallus Eckloniae) extract is absorbed the big of difficulty
Molecule active principle carries out biological decomposition, makes it easier for being less readily available for absorption by the skin, to more effectively play moisturizing anti-aging
Effect is easily absorbed using biofermentation technique, non-stimulated, meets requirement of the people to cosmetics safety validity, application prospect
It is wide.
Claims (2)
1. a kind of compound of the yeast extractive from fermentative of moisturizing anti-aging, it is characterised in that: the compoiste fermented object by below at
Be grouped as: yeast tunning extract, saccharomycete river paddy seed tunning filtrate, surplus are that the fermentation of saccharomycete laminariose produces
Object, it is 20%-30%, saccharomycete river paddy seed tunning filtrate that wherein yeast tunning extract, which accounts for composition total weight proportion,
Accounting for composition total weight proportion is 20%-30%, and surplus is saccharomycete laminariose tunning.
2. a kind of preparation method of compoiste fermented object with moisturizing senile-resistant efficacy according to claim 1, feature
It is: includes the following steps:
30 DEG C of activated yeast of step 1:YM culture medium (no agar) are cultivated 2 days, are accessed to 20kgYM culture medium (no agar)
The constant-temperature table culture 2 days of 30 DEG C of 0.2-0.4kg activated yeast obtains saccharomycetes to make fermentation liquid, and 0.1-0.3%NaCl self-dissolving 24- is added
30h, filtering and impurity removing remove cell wall and insoluble molecule, and 70 DEG C of vacuum distillations remove ethyl alcohol, obtain the extraction of yeast tunning
Object；
Step 2: river paddy seed being cleaned up, is crushed, 30-40 DEG C of ultrasonic extraction 20-40min of 10-15 times of pure water is added, filters at a slow speed
Paper filtering, obtains river paddy seed extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no fine jade after sterilizing
Rouge) 30 DEG C of activated yeast cultivate 3 days, to 20kg sterilized cooling river paddy seed extracting solution access 0.2-0.4kg activated yeast
The constant-temperature table culture 2 days of 30 DEG C of bacterium obtains saccharomycete river paddy seed tunning, and 0.1-0.3%NaCl self-dissolving 24-30h, filtering is added
Removal of impurities removal cell wall and insoluble molecule, remove ethyl alcohol, obtain saccharomycete river paddy seed tunning filtrate；
Step 3: thallus laminariae being cleaned up, is shredded, 70-90 DEG C of water-bath 2-3h of 10-15 times of pure water is added, slow filter paper filtering obtains
Laminariose extracting solution, 121 DEG C of high pressure steam sterilization 30min are cooled to 30 DEG C, YM culture medium (no agar) activated yeast after sterilizing
30 DEG C of bacterium cultivate 3 days, to 20kg sterilized cooling laminariose extracting solution access 30 DEG C of constant temperature of 0.2-0.4kg activated yeast shake
Bed culture 2 days, obtains saccharomycete laminariose tunning, and 0.1-0.3%NaCl self-dissolving 24-30h is added, and filtering and impurity removing removes cell
Wall and insoluble molecule remove ethyl alcohol, obtain saccharomycete laminariose tunning；
Step 4: yeast tunning extract, saccharomycete river paddy seed tunning filtrate and saccharomycete prepared by step 1-3
Laminariose tunning adds by a certain percentage, and dissolution is fitted into the bottle sterilized after mixing.
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| CN110403881A (en) * | 2019-08-29 | 2019-11-05 | 湖北省麦诗特生物科技有限公司 | A kind of preparation method and application of the river paddy seed tunning extract with white-skinned face function |
| CN110478308A (en) * | 2019-09-09 | 2019-11-22 | 花安堂生物科技集团有限公司 | A kind of cosmetic composition of the extract containing yeast-raised products and preparation method thereof |
| CN112933028A (en) * | 2021-04-19 | 2021-06-11 | 广州广妆生物科技有限公司 | Skin lotion containing anti-aging composition and preparation method thereof |
| CN113116798A (en) * | 2021-04-19 | 2021-07-16 | 广东梵蜜琳生物科技有限公司 | Face cream containing anti-aging composition and preparation method thereof |
| CN113143830A (en) * | 2021-04-19 | 2021-07-23 | 广东梵蜜琳生物科技有限公司 | Eye cream containing anti-aging composition and preparation method thereof |
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| CN113425662A (en) * | 2021-08-16 | 2021-09-24 | 湖州伊婷生物科技有限公司 | Hyaluronic acid and dendrobium officinale yeast fermentation product composition and cosmetic |
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