CN109276278B - Small animal subcutaneous tumor drawing holder - Google Patents

Small animal subcutaneous tumor drawing holder Download PDF

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Publication number
CN109276278B
CN109276278B CN201811429850.8A CN201811429850A CN109276278B CN 109276278 B CN109276278 B CN 109276278B CN 201811429850 A CN201811429850 A CN 201811429850A CN 109276278 B CN109276278 B CN 109276278B
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rod
sleeved
small
piston
piston rod
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CN109276278A (en
Inventor
王文佳
马霞
郭振环
王秀君
李宇伟
李向辉
陈忠杰
侯春彬
刘永录
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Henan University of Animal Husbandry and Economy
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Henan University of Animal Husbandry and Economy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses a small animal subcutaneous tumor extraction holder, which comprises a syringe barrel, a piston body, a piston rod, a rear seat and a needle, wherein the needle is fixedly arranged at the front end of the syringe barrel, the piston body is matched and sleeved in the syringe barrel, the piston rod is fixed at the rear end of the piston body, the rear seat is positioned at the rear end of the piston rod, the axial center positions of the piston body and the piston rod are of an integrated hollow structure, the rear end of the central hole is sealed by the rear seat, a core rod is sleeved in a needle tube and the central hole, the core rod comprises a small diameter section and a large diameter section, the small diameter section is matched and sleeved in the needle tube, and a stop part for limiting excessive rear movement of the core rod is arranged in the middle section of the piston rod, which is matched and sleeved in the central hole. According to the invention, the core rod can be driven by the piston to move forwards and backwards, but no matter the core rod is in the front pole position or the rear pole position, the core rod is always positioned in the needle tube, so that the subcutaneous tumor sample of the small animal is always reserved at the inner side of the needle tube, and the subcutaneous tumor sample cannot enter the cylinder of the injector, and a small amount of sampling and effectiveness are ensured.

Description

Small animal subcutaneous tumor drawing holder
Technical Field
The invention belongs to the technical field of sampling tools for animal husbandry and veterinary and medical animal model experiments, and particularly relates to a sampling holder suitable for accurately and rapidly extracting subcutaneous tumors of small animals.
Background
When small animals such as cats and pet dogs, and small laboratory animals such as guinea pigs, rats, mice, tree shrews and the like are subjected to subcutaneous sampling, samples are often extracted from subcutaneous tumors for pathological analysis and disease prevention and control, and no better tool is used in the current mode of syringe suction. When the injector is used for sucking, the operation difficulty is very high, and often the operation is difficult to be finished by a single person. Firstly, an operator needs to control the position of a tumor of a small animal by one hand so as to be convenient for accurate needle insertion, and the other hand needs to complete the suction process of the syringe, so that the suction intensity of the syringe is difficult to accurately control when the syringe is controlled to suck by one hand. Because the subcutaneous tumor sample amount of the small animal is very small, the small animal only remains in the needle tube when sucked by the syringe, and if the sample is sucked into the syringe cylinder, the sample cannot be taken out, and the sampling fails. Moreover, when sampling by the injector, even if the sampling is completed by a plurality of people, the accurate sampling result is difficult to achieve, the sampling time is long, the operation difficulty is high, and the animal fixing is difficult. The animals are in a stress state for a long time, and damage to the animals is easily caused.
Disclosure of Invention
Aiming at the problems that the operation difficulty is high, the sampling process is difficult to be effectively completed by a single person, the sampling process is easy to cause sampling loss and the like in the current small-amount sampling process of small animals, the invention provides a small-animal subcutaneous tumor extraction holder, and aims to simplify the operation and improve the sampling success rate and the sampling efficiency.
The invention solves the technical problems by adopting the scheme that: the utility model provides a small animal subcutaneous tumor extraction holder, includes syringe barrel, piston body, piston rod and backseat and needle tubing, and wherein needle tubing fixed mounting is in the front end of syringe barrel, and the piston body matches the suit in the syringe barrel, and the piston rod is fixed in the piston body rear end, and the backseat is located the piston rod rear end, the hollow structure as an organic whole in the axle center position of piston body and piston rod, and as the centre bore, the rear end in centre bore is sealed by the backseat, is equipped with the core bar in the needle tubing and in the centre bore cover, and this core bar includes thin footpath section and thick footpath section, and thin footpath section matches the suit in the needle tubing, and thick footpath section matches the suit in the centre bore, and the length of thin footpath section is not greater than the length of needle tubing, is provided with the stop member that restricts excessive backward movement of core bar in the middle section of piston rod.
Further, a manual push-pull drive mechanism is provided between the syringe barrel and the rear seat. The manual push-pull driving mechanism is characterized in that an inherent annular sleeve is sleeved at the front end of the outer side of the syringe barrel, fixed spring plate seats are symmetrically arranged on two sides of the annular sleeve, movable spring plate seats are symmetrically arranged on two sides of the rear seat, and an outwards-protruding arched spring plate is arranged between the corresponding fixed spring plate seat and the corresponding movable spring plate seat.
Wherein, the outside of the small diameter section of the core rod is sleeved with an inherent small diameter sleeve, and the outside of the large diameter section is provided with an air vent groove.
The stop component can be realized in a plurality of modes, and firstly, a side hole is arranged at the middle section of the piston rod, and a stop pin is sleeved in the radial direction, and the stop pin penetrates into the inner side of the central hole and is used for limiting the rear end of the core rod. The second mode of the stop component is that an inner sleeve rod is connected in the central hole of the piston rod in a threaded manner, and the outer end of the inner sleeve rod is positioned outside the central exhaust hole of the rear seat.
The invention has the beneficial effects that: according to the invention, the core rod can be driven by the piston to move forwards and backwards, but no matter the core rod is in the front pole position or the rear pole position, the core rod is always positioned in the needle tube, so that the subcutaneous tumor sample of the small animal is always reserved at the inner side of the needle tube, and the subcutaneous tumor sample cannot enter the cylinder of the injector, and a small amount of sampling and effectiveness are ensured.
When the invention is used, the problem that the piston rod exceeds the moving range is not needed to be considered, and an experimenter only needs to operate the piston rod to a position where the piston rod does not move any more, so that the operation is very simple, the accurate moving degree is not needed to be considered, the accuracy of sampling and the operation efficiency are improved, and the experimental process is simplified.
When the invention is driven by means of the arched spring, the arched spring is only required to be pressed and released. The arc-shaped elastic sheet is tightly held by the hand during sampling to deform the needle tube, the problem of deformation degree of the elastic sheet is not considered, quick one-step sampling is realized, a small amount of sample in the needle tube can be discharged to a corresponding observation position only by loosening the arc-shaped elastic sheet during lofting, the operation steps are further simplified, and the operation process can be completed by one hand.
Drawings
Fig. 1 is a schematic view of the appearance of the present invention.
Fig. 2 is a schematic view of the internal structure of fig. 1.
Fig. 3 is a schematic diagram of the compressed state of fig. 2.
Fig. 4 is a schematic view of the core pin of fig. 2.
FIG. 5 is a schematic diagram showing the comparison of the extreme movement states of the two ends of the core rod.
Fig. 6 is a schematic view of a construction employing an inner race rod stop member.
Detailed Description
Example 1: the small animal subcutaneous tumor extraction holder shown in fig. 1 mainly comprises a syringe barrel 1, a piston body 2, a piston rod 3, a rear seat 4, a needle tube 5, an arched spring plate 7, a core bar 6 and other components. The front end of the syringe barrel 1 is provided with an inserting joint or a threaded joint, the back side of the needle tube is provided with a needle seat 13, and the needle seat 13 and the inserting joint or the threaded joint of the syringe barrel 1 are hermetically installed together. A piston body 2 is arranged in the injector cylinder body 1 in a matching way, a piston rod 3 is fixed at the rear end of the piston body 2, a rear seat 4 is fixed at the rear end of the piston rod 3, and the rear seat 4 is positioned outside the injector cylinder body 1. The rear end of the syringe barrel 1 is provided with a positioning sleeve 15, the piston rod 3 passes through a through hole arranged in the center of the positioning sleeve 15, and the positioning sleeve 15 is provided with an edge exhaust hole 16 so as to facilitate the exhaust and the suction of the piston in the moving process.
Further, a center hole 9 of a hollow structure is provided at the axial center position of the piston body 2 and the piston rod 3, and the center hole 9 penetrates the piston rod 3, and after the piston rod is fixed with the rear seat, the rear end of the center hole 9 located at the piston rod is sealed by the rear seat. Since the axial center of the needle tube 5 coincides with the axial center of the center hole 9, the lumen of the needle tube 5 corresponds to the position of the center hole 9.
Referring to fig. 2, a core rod 6 as shown in fig. 4 is sleeved in the needle tube 5 and the central hole 9, the core rod 6 comprises a small diameter section 61 and a large diameter section 62, the small diameter section 61 is matched and sleeved in the needle tube 5, and the large diameter section 62 is matched and sleeved in the central hole 9. Moreover, the length of the small diameter section 61 is not longer than the length of the needle tube 5. In addition, a side hole is formed in the middle section of the piston rod 3, and a retaining pin 10 is sleeved in the radial direction, wherein the retaining pin 10 penetrates into the inner side of the center hole 9 to limit the rear end of the core rod 6.
When the piston rod 3 is driven to drive the piston body 2 to move forwards and backwards, after the piston body 2 is pulled backwards, as shown in fig. 5, the space of the closed cavity 17 at the front end of the piston body 2 is enlarged, and the enlarged volume v1=pi r is increased 1 2 * Δb, absorption volume v2=pi r after traversing core rod 6 2 2 * Δa, and v1=v2, whereby Δa=r 1 2 / r 2 2 * Δb, where r 1 Radius r of piston body 2 2 Is the radius of the small diameter section 61 of the core pin 6. It can be seen that the piston rod 3 moves backward by a small displacement, so that the core rod 6 is driven to have a large displacement. Because the stop pin 10 is arranged in the middle of the piston rod 3, the core rod 6 is prevented from moving after being moved backwards to touch the stop pin 10, and the degree of negative pressure in the closed cavity 17 is increased when the piston body 2 is moved backwards continuously, so that the piston body 2 is difficult to move further. After the core bar 6 is moved backwards, the subcutaneous tumor sampling of the small animals can be always positioned at the inner side of the needle tube 5. It can be seen that, in the present invention, the core rod 6 also acts as a piston, and in order to enhance the pumping and pushing effects of the core rod 6 during movement, a structure as shown in fig. 5 may be adopted, that is, a small diameter sleeve 63 is sleeved outside a small diameter section 61 of the core rod 6, and an air vent groove 14 is provided outside the large diameter section 62. It is generally necessary to provide an annular groove on the outside of the small diameter section 61, glue the groove and fit the small diameter sleeve 63 around it.
Example 2: embodiment 1 provides and drives core bar 6 motion through driving the piston to remove, utilizes the front pole position and the back pole position of core bar 6 as quantitative swift mode of taking the lofting, ensures that the animal subcutaneous mass sample remains in needle tubing 5 is inboard all the time, can not get into syringe barrel 1, and the operation process becomes very simple moreover, no longer need consider the accurate degree of moving of piston rod 3, reaches the purpose that improves the accuracy and the operating efficiency of sample. In order to further improve the convenience of operation, a manual push-pull driving mechanism is arranged between the syringe barrel 1 and the rear seat 4.
As shown in fig. 2 and 3, the manual push-pull driving mechanism is characterized in that an inherent annular sleeve is sleeved at the front end of the outer side of the syringe barrel 1, fixed spring plate seats 11 are symmetrically arranged at two sides of the annular sleeve, and movable spring plate seats 12 are symmetrically arranged at two sides of the rear seat 4. An arch spring 7 protruding outwards is arranged between the corresponding fixed spring seat 11 and the corresponding movable spring seat 12, and a rubber pad 8 is sleeved on the outer side of the arch spring for holding. The operation is only needed to press the arch spring 7 and release the arch spring 7. The arch shell fragment 7 is tightly held with the hand when taking a sample and makes its deformation, need not consider the shell fragment degree of deformation problem, realizes quick one step sample, only need loosen arch shell fragment 7 during the lofting and can discharge the corresponding observation position with the interior a small amount of sample of needle tubing 5, through the improvement of this embodiment, can realize that the one-hand operation accomplishes sample and lofting process.
Example 3: based on the above embodiments 1 and 2, the longer needle cannula 5 and the corresponding core rod 6 may be replaced in order to change the sampling amount to accommodate different small animals or different tissue samples. By providing a movable stop, one way is to screw an inner sleeve 18 (on which the threaded section 19 is provided) in the piston rod 3 as shown in fig. 6. The position of the inner sleeve 18 in the piston rod 3 is used to control the position of the stop at the rear end of the core rod 6. Thereby providing the possibility to vary the length of the needle cannula 5 and the core pin 6, i.e. the amount of the sample.
Example 4: based on example 3 above, the thicker needle cannula 5 and corresponding core cannula 6 may be replaced in order to vary the amount of samples to accommodate different small animals or different tissue samples. The movable stopper member shown in fig. 6 is also employed.

Claims (3)

1. The utility model provides a small animal subcutaneous tumor extraction holder, includes syringe barrel, piston body, piston rod and backseat and needle tubing, and wherein needle tubing fixed mounting is in the front end of syringe barrel, and the piston body matches the suit in the syringe barrel, and the piston rod is fixed at the piston body rear end, backseat rear end characterized by: the piston body and the piston rod are of a hollow structure with an integral axial center, the rear end of the central hole is sealed by a rear seat, a core rod is sleeved in the needle tube and the central hole, the core rod comprises a small-diameter section and a large-diameter section, the small-diameter section is matched and sleeved in the needle tube, the large-diameter section is matched and sleeved in the central hole, the length of the small-diameter section is not greater than that of the needle tube, a small-diameter sleeve is sleeved outside the small-diameter section of the core rod, and an air vent groove is formed outside the large-diameter section; a stop component for limiting excessive backward movement of the core rod is arranged at the middle section of the piston rod; a manual push-pull driving mechanism is arranged between the syringe barrel and the rear seat, the manual push-pull driving mechanism is a fixed annular sleeve sleeved at the front end of the outer side of the syringe barrel, fixed spring plate seats are symmetrically arranged on two sides of the annular sleeve, movable spring plate seats are symmetrically arranged on two sides of the rear seat, and an outwards-protruding arched spring plate is arranged between the corresponding fixed spring plate seat and the corresponding movable spring plate seat.
2. The small animal subcutaneous tumor extraction holder of claim 1, wherein: the stop component is provided with a side hole at the middle section of the piston rod and is sleeved with a stop pin which is arranged in the radial direction, and the stop pin penetrates into the inner side of the central hole and is used for limiting the rear end of the core rod.
3. The small animal subcutaneous tumor extraction holder of claim 1, wherein: the stop part is formed by connecting an inner sleeve rod with the inner thread of a central hole of the piston rod, and the outer end of the inner sleeve rod is positioned outside a central exhaust hole of the rear seat.
CN201811429850.8A 2018-11-28 2018-11-28 Small animal subcutaneous tumor drawing holder Active CN109276278B (en)

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Application Number Priority Date Filing Date Title
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CN109276278B true CN109276278B (en) 2023-09-01

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WO2007065324A1 (en) * 2005-12-10 2007-06-14 Shandong Weigao Group Medical Polymer Co., Ltd A disposable safety syringe
WO2009097743A1 (en) * 2008-02-04 2009-08-13 Dongsen Fang Core rod locking device for safety syringe
CN104837414A (en) * 2012-10-08 2015-08-12 德维克医疗产品公司 Tissue biopsy device with thumbwheel and sample holder
CN204789014U (en) * 2015-06-26 2015-11-18 河南农业大学 Organize sample thief
CN204971368U (en) * 2015-09-23 2016-01-20 河南牧业经济学院 Ox uterus sample thief
CN205391136U (en) * 2016-02-28 2016-07-27 李正旺 Tumour sampler
CN105953009A (en) * 2016-06-24 2016-09-21 中航光电科技股份有限公司 Male connector, female connector and fast connector assembly
CN205698743U (en) * 2016-05-09 2016-11-23 官晓斐 Independently have an injection and use syringe
CN205729409U (en) * 2016-02-01 2016-11-30 王英浩 A kind of novel tumor biopsy sampler
CN106236215A (en) * 2016-07-08 2016-12-21 江苏风和医疗器材有限公司 A kind of medical load-engaging device
CN107595324A (en) * 2017-09-29 2018-01-19 施康培医疗科技（武汉）有限公司 A kind of full-automatic negative-pressure aspirates rotating cutting type biopsy needle
CN207693596U (en) * 2017-06-28 2018-08-07 柯慧 A kind of Internal Medicine-Oncology sampler
CN108433752A (en) * 2018-01-15 2018-08-24 温州市人民医院 A kind of gastric cancer holostrome specimen sampler
CN209450571U (en) * 2018-11-28 2019-10-01 河南牧业经济学院 Toy subcutaneous mass extracts holder

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5651372A (en) * 1995-06-28 1997-07-29 Caillouette; James C. Biopsy syringe
WO2007065324A1 (en) * 2005-12-10 2007-06-14 Shandong Weigao Group Medical Polymer Co., Ltd A disposable safety syringe
WO2009097743A1 (en) * 2008-02-04 2009-08-13 Dongsen Fang Core rod locking device for safety syringe
CN104837414A (en) * 2012-10-08 2015-08-12 德维克医疗产品公司 Tissue biopsy device with thumbwheel and sample holder
CN204789014U (en) * 2015-06-26 2015-11-18 河南农业大学 Organize sample thief
CN204971368U (en) * 2015-09-23 2016-01-20 河南牧业经济学院 Ox uterus sample thief
CN205729409U (en) * 2016-02-01 2016-11-30 王英浩 A kind of novel tumor biopsy sampler
CN205391136U (en) * 2016-02-28 2016-07-27 李正旺 Tumour sampler
CN205698743U (en) * 2016-05-09 2016-11-23 官晓斐 Independently have an injection and use syringe
CN105953009A (en) * 2016-06-24 2016-09-21 中航光电科技股份有限公司 Male connector, female connector and fast connector assembly
CN106236215A (en) * 2016-07-08 2016-12-21 江苏风和医疗器材有限公司 A kind of medical load-engaging device
CN207693596U (en) * 2017-06-28 2018-08-07 柯慧 A kind of Internal Medicine-Oncology sampler
CN107595324A (en) * 2017-09-29 2018-01-19 施康培医疗科技（武汉）有限公司 A kind of full-automatic negative-pressure aspirates rotating cutting type biopsy needle
CN108433752A (en) * 2018-01-15 2018-08-24 温州市人民医院 A kind of gastric cancer holostrome specimen sampler
CN209450571U (en) * 2018-11-28 2019-10-01 河南牧业经济学院 Toy subcutaneous mass extracts holder

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