CN109258932A - Fullerene feed for pet additive and preparation method thereof and feed - Google Patents
Fullerene feed for pet additive and preparation method thereof and feed Download PDFInfo
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- CN109258932A CN109258932A CN201811365697.7A CN201811365697A CN109258932A CN 109258932 A CN109258932 A CN 109258932A CN 201811365697 A CN201811365697 A CN 201811365697A CN 109258932 A CN109258932 A CN 109258932A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
- A23D7/04—Working-up
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to field of fodder, a kind of fullerene feed for pet additive and preparation method thereof and feed are specifically disclosed.Contain fullerene microcapsule powder, vitamin, mineral trace element liquid, DL- METHIONINE, bacillus powder and rush digestive pharmaceutical in the fullerene feed for pet additive, and on the basis of the total weight of the fullerene feed for pet additive, the content of the fullerene microcapsule powder is 20-90wt%, the content of the vitamin is 5-35wt%, the content of the mineral trace element liquid is 0.01-10wt%, the content of the DL- METHIONINE is 0.5-20wt%, the content of the bacillus powder is 0.01-10wt%, and the content for promoting digestive pharmaceutical is 0.01-5wt%.The immunity and disease resistance of pet can be improved in fullerene feed for pet additive provided by the invention, reduces the illness rate of pet, and promote pet gastrointestinal disturbances, adjusts stomach anti-diarrhea.
Description
This application claims enjoy submitted on March 27th, 2018 application No. is 201810259287.8, entitled " fowlers
Alkene be used to be prepared into the purposes of fullerene microcapsule powder " priority, and the full content of the patent application is incorporated herein
As reference.
Technical field
The invention belongs to field of fodder, and in particular to a kind of fullerene feed for pet additive and preparation method thereof and raise
Material.
Background technique
Fullerene (Fullerene) is the third allotrope that simple substance carbon is found.It is any by a kind of element group of carbon
At with substance existing for spherical, ellipticity or tubular structure, fullerene can be called, and fullerene refers to a substance.
The most molecule of content is C in fullerene family60, secondly it is C70、C76、C82、C84Deng.Due to the special structure of fullerene and
Performance, the subjects such as material, chemistry, superconduction and Semiconductor Physics, biology and lasing safety, catalyst, fuel, lubricant,
Grinder, high-strength carbon fiber, high-energy battery, synthesis, cosmetics, quantum computer, sensor, molecular device and for curing
Study as and treat etc. has important researching value and application prospect.The preparation method of fullerene mainly has electric arc at present
Method, thermal evaporation, catalyst method, combustion method and chemical vapour deposition technique etc..And the application of fullerene in daily life is got over
Come it is more extensive, therefore fullerene product future society have good development prospect.
Fullerene has multiple excellent performance, and contains various bioactivators and function factor, has very high
Medical treatment, health value.The performance that free radical is efficiently removed using fullerene, is applied to Cosmetic Market for Functional Fullerene,
Vast potential for future development is showed.It uses in raising pets using fullerene as feed addictive at present and and other components
Cooperation is collectively as feed addictive, and but there has been no cross related technology reports.
Transformation with the improvement of people ' s living standards and in consumption idea, to the quality of life and health status of pet
Also increasingly pay attention to, feed for pet additive also just enters pet family naturally, while showing feed for pet additive
It is worth with potential great market.It is very big for the feed for pet additive market demand both at home and abroad, it therefore, can be for difference
The pet of age level, different cultivars develops different feed for pet additives, and feed for pet additive is added to pet and is raised
In material, by the application of feed for pet additive, efficiency of feed utilization is improved, improves feed palatability, the growth of pet is promoted to send out
It educates, improves immunity function, increase the premunition to disease.
Summary of the invention
The present invention is intended to provide a kind of new fullerene feed for pet additive and preparation method thereof and feed.
Specifically, the present invention provides a kind of fullerene feed for pet additives, wherein the fullerene feed for pet adds
Add in agent containing fullerene microcapsule powder, vitamin, mineral trace element liquid, DL- METHIONINE, bacillus powder and rush digestion
Agent, and on the basis of the total weight of the fullerene feed for pet additive, the content of the fullerene microcapsule powder is 20-
90wt%, the content of the vitamin are 5-35wt%, and the content of the mineral trace element liquid is 0.01-10wt%, institute
The content for stating DL- METHIONINE is 0.5-20wt%, and the content of the bacillus powder is 0.01-10wt%, the rush digestive pharmaceutical
Content be 0.01-5wt%.
Preferably, fullerene compound, nutrition compounding oil, food emulsifier and wall are contained in the fullerene microcapsule powder
Material.
Preferably, on the basis of the total weight of the fullerene microcapsule powder, the fullerene compound and nutrition compounding
The total weight content of oil is 10-80wt% and the weight content of the fullerene compound is 0.1-5wt ‰, the edible cream
The weight content of agent is 0.01-5wt%, and the weight content of the wall material is 0.01-80wt%.
Preferably, on the basis of the total weight of the fullerene microcapsule powder, the weight content of the fullerene compound
Weight content for 1-5wt ‰, the nutrition compounding oil is 50-70wt%, and the weight content of the food emulsifier is nutrition
The 4-6wt% of fat weight content in compounding oil, the weight content of the wall material are 29-49wt%.
Preferably, the partial size of the fullerene microcapsule powder is 5-500 μm.
Preferably, the fullerene compound can be C60And its derivative, C70And its derivative, fullerene metal
Derivative, fullerene containing oxygen derivative, through it is organic compound modified or inclusion fullerene, through it is organic compound modified or inclusion
At least one of fullerene derivate.Wherein, on the oxygen atom in the fullerene containing oxygen derivative and fullerene skeleton
Carbon atom be connected or be bonded with alkylidene chain.It is described derivative through organic compound modified or inclusion fullerene and fullerene
Organic matter in object can be the existing various organic oligomers for being capable of forming inclusion or complex compound, such as can paste for ring
Essence and/or crown ether.
The nutrition compounding oil is in edible oil, fat soluble vitamin, hydro carbons, fatty acid, higher alcohols and esters
At least one.Wherein, the edible oil includes vegetable oil and animal oil.The vegetable oil be preferably selected from soybean oil, rapeseed oil,
Palm oil, olive oil, sunflower oil, shinyleaf yellowhorn oil, Seabuckthorm Seed Oil, corn oil, safflower oil, Purple Perilla Seed Oil, tea-seed oil, tea seed
Oil, cottonseed oil, coconut oil, sesame oil, linseed oil, pumpkin seed oil, peony seed oil, hippophae rhamnoides fruit oil, walnut oil, Korean Pine seed,
In evening primrose oil, safflower seed oil, borage oil, fiery flaxseed oil, salad oil, wheat-germ oil, avocado oil and Seabuckthorn Oil at least
It is a kind of.The animal oil is preferably selected from least one of lard, butter, sheep oil, fish oil, house oil and turtle oil.The hydro carbons
Preferably saualane and/or squalene.The fatty acid be preferably selected from oleic acid, linoleic acid, linolenic acid, conjugated linoleic acid,
At least one of DHA, stearic acid, lauric acid, arachidonic acid and EPA.The higher alcohols are preferably selected from octyldodecyl
At least one of alcohol, laruyl alcohol, phytosterol, cholesterol and stearyl alcohol.The esters are preferably conjugated linoleic acid glycerol three
Ester and/or glyceryl linoleate.Most preferably, the nutrition compounding oil is linseed oil, safflower seed oil, Purple Perilla Seed Oil, oil tea
Seed oil, sunflower oil, soybean oil, olive oil, pumpkin seed oil, evening primrose oil, borage oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, tree peony
Seed oil, shinyleaf yellowhorn oil, Seabuckthorn Oil, fiery sesame oil, linoleic acid, linolenic acid, linoleic acid triglyceride, conjugated linoleic acid, is total to walnut oil
Two or more combinations in conjugated linoleic acid triglycerides.
The food emulsifier can be in existing various molecular structures to there is hydrophily to have lipophilicity again, because of amphiphilic
Property and with surface-active substance, can be anionic surfactant, cationic surface active agent, non-ionic table
Face activating agent or amphoteric surfactant.The specific example of the food emulsifier includes but is not limited to: sucrose fatty ester,
Polyglyceryl fatty acid ester, fatty acid glyceride, polyoxyethylene sorbitan fatty acid ester, casein sodium, lecithin, tristearin
Sour sodium, glycine betaine, amino-acid salt, succinic acid fatty acid glyceride, stearoyl lactate, is spat single glycerine organic acid aliphatic ester
At least one of temperature -80, Arlacel-80, polyglycerol ester, propylene glycol fatty acid rouge and polyoxyethylene sorbitan fatty acid ester；Alternatively, described
Food emulsifier is A or the mixture of A and B, and A is one of oligofructose, resistant dextrin, skimmed milk power or two kinds, B
For casein sodium, list, diglycerine fatty acid ester, starch Sodium Octenyl Succinate, ascorbic acid, sodium ascorbate, phosphatide, day
One of right vitamin E, sodium tripolyphosphate and ascorbyl palmitate.
The effect of the wall material is to form the film with some strength, and improve microencapsulated oil powder.The wall material is preferred
It, specifically can be selected from maltodextrin (DE18 or DE20), soybean protein isolate (SPI), Arab for water-soluble high-molecular material
Glue (GA), beta-cyclodextrin, starch (cornstarch, modified starch, porous-starch, methylhydroxypropyl starch), Whey Protein Concentrate
(WPC), dextrin, corn syrup, gelatin, sodium carboxymethylcellulose (CMC), xanthan gum, agar, carragheen, chitosan, octenyl
Succinic acid starch ester, guar gum, seaweed glue, alginate, lactoprotein, casein, mucedin, gliadin, Dai Ke
It can rouge, caseinic acid (SC), vegetable protein, lactose, sucrose, maltose, methylcellulose, ethyl cellulose, methylhydroxypropyl
In cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, avicel cellulose and water-soluble dietary fiber
It is at least one.Preferably, the wall material is soybean protein isolate, xanthan gum, converted starch, gelatin, carboxymethyl cellulose, malt
Two kinds or three kinds or more in dextrin mix.
Preferably, the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid: monounsaturated fatty acids: mostly not
Saturated fatty acid weight ratio is 1:(0.5-2): (0.5-2), the polyunsaturated fatty acid Linoleic acid: linolenic acid by weight ratio is
1:(0.5-2)。
Preferably, the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid: monounsaturated fatty acids: mostly not
Saturated fatty acid weight ratio is 1:(0.5-1.5): (0.5-1.5), the polyunsaturated fatty acid Linoleic acid: linolenic acid by weight
Than for 1:(0.5-1.5).
It is highly preferred that the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid: monounsaturated fatty acids: more
Unsaturated fatty acid weight ratio is 1:1:1, and the polyunsaturated fatty acid Linoleic acid: linolenic acid by weight ratio is 1:1.
Preferably, stabilizer and/or glidant are also contained in the fullerene microcapsule powder.
Preferably, on the basis of the total weight of the fullerene microcapsule powder, the weight content of the stabilizer is 0.01-
20wt%, the weight content of the glidant are 0.01-2wt%.
The stabilizer can be the existing various substances for enabling to fullerene capsule performance stable, can be for chela
The organic acid of cooperation or its salt, specific example include but is not limited to: arabo-ascorbic acid and its salt, gallic acid and its derivative
Object, gluconic acid, sodium tripolyphosphate, composite phosphate, dipotassium hydrogen phosphate, polyphosphate sodium, sodium metaphosphate, sodium carboxymethylcellulose
At least one of with agar.
The glidant can assign forming the better mobility of component of fullerene capsule in order to form.It is described to help stream
The specific example of agent includes but is not limited to: silicate, stearate, molysite, phosphate, polysaccharide, talcum powder, calcium carbonate and two
At least one of zinc oxide.Wherein, the silicate can be selected from silica, calcium silicates, lagoriolite, magnesium silicate and silicon
At least one of sodium aluminate.The stearate can be in odium stearate, calcium stearate, aluminum stearate and zinc stearate
At least one.The molysite can be ammonium iron citrate and/or cyanogen ferrisodium.The phosphate can be calcium phosphate and/or phosphorus
Sour magnesium.The polysaccharide can be depolymerization starch and/or crystallite depolymerizing cellulose.
Preferably, (1) or mode (2) are prepared the fullerene microcapsule powder in the following ways:
Mode (1):
It is oily mutually to prepare: to prepare the nutrition compounding oil by fatty acid proportion, then the fullerene compound sterilizes
After be dissolved into nutrition compounding oil, at oily compound is compounded, the food emulsifier is dissolved into the oily compound of compounding later,
Obtain oily phase；
Water phase preparation: the wall material is dissolved in hot water and obtains water phase；Preferably, the temperature of hot water is 60-80 DEG C；
Mixing sterilizing: gained water phase is mixed with oil and is stirred evenly, is then sterilized；
Homogeneous, spray drying: homogeneous, spray drying obtain fullerene microcapsule powder；
Mode (2):
The fullerene compound is dissolved in the nutrition compounding oil, fullerene oil solution is obtained；
By the fullerene oil solution, wall material, food emulsifier and selectively the stabilizer that contains and glidant mix,
Dissolution, dispersion, homogeneous, are made emulsion, and gained emulsion is carried out homogeneous, is later spray-dried homogeneous lotion.
Preferably, in mode (1) and mode (2), the mixing carries out in a shear condition, and the mixed condition packet
Including temperature is 50-80 DEG C, shear rate 10000-15000rpm, time 2-10min.
Preferably, the pressure of the homogeneous is 30-35MPa, and number is 2-5 times.
Preferably, it is 180-240 DEG C that the condition of the spray drying, which includes inlet air temperature, and leaving air temp is 75-85 DEG C.
Preferably, on the basis of the total weight of the fullerene feed for pet additive, the fullerene microcapsule powder contains
Amount is 30-85wt%, more preferably 40-80wt%, most preferably 60-80wt%.
Contain vitamin and mineral liquid microelement in fullerene feed for pet additive provided by the invention simultaneously, it can
To provide reasonable microelement and vitamin for feed for pet, the nutritional balance of feed is improved.
Preferably, on the basis of the total weight of the fullerene feed for pet additive, the content of the vitamin is 10-
25wt%, more preferably 12-20wt%.
Preferably, the vitamin contains vitamin A, vitamin B1, vitamin B6 and vitamin D；With the fullerene
On the basis of the total weight of feed for pet additive, the content of the vitamin A is 3-15wt%, is preferably 4-12wt%, is more excellent
It is selected as 8-10wt%, the content of the vitamin B1 is 0.01-5wt%, preferably 0.1-5wt%, more preferably 0.5-
2wt%, the content of the vitamin B6 are 0.01-5wt%, preferably 0.1-5wt%, more preferably 0.5-2wt%, the dimension
The content of raw element D is 1-8wt%, preferably 2-6wt%, more preferably 3-6wt%.
The specific example of contained mineral trace element includes but is not limited in the mineral trace element liquid: copper, zinc,
At least one of manganese, iodine, iron, phosphorus, cobalt, selenium etc., specifically can with copper sulphate, zinc sulfate, manganese sulfate, potassium iodide, chelate iron,
At least one form such as ammonium dihydrogen phosphate, cobalt chloride, sodium selenite uses.A preferred embodiment of the invention,
Contain copper, zinc, manganese, iodine, iron, phosphorus, cobalt and selenium, and the micro member of minerals described in every 100mL in the mineral trace element liquid
Copper content is 0.41-0.68mg, Zn content 200-250mg, manganese content 16.12-21mg, content of iodine 10- in plain liquid
15.5mg, iron content 150-200mg, phosphorus content 45-86mg, cobalt content 0.36-0.80mg, Se content 2-3mg.This
Outside, on the basis of the total weight of the fullerene feed for pet additive, the content of the mineral trace element liquid is preferably
0.1-5wt%, most preferably 0.5-2wt%.
The DL- METHIONINE is sulfur-containing amino acid, and the characteristics of hair protein matter organizer is exactly the content of sulfur-containing amino acid
Highest, supplement DL- METHIONINE can provide nutrition not only for hair growth, stimulate broken hair regeneration, and DL- METHIONINE can also
Composition hemoglobin, tissue and serum are participated in, the operating of spleen, pancreas and lymph is promoted.Added with the fullerene feed for pet
On the basis of the total weight for adding agent, the content of the DL- METHIONINE is preferably 2-15wt%, more preferably 4-12wt%.
After the bacillus powder enters animal intestinal tract, it can be brought back to life rapidly in upper intestines while secrete various digestive ferments such as
Amylase, protease and lipase etc. promote the degradation of carbohydrate in feed, generate the substances such as antibiotic and fly up and down pathogenic bacteria, simultaneously
After bacillus field planting is in enteron aisle, anaerobic environment can be formed by consuming a large amount of oxygen, pathogen is numerous in inhibition enteron aisle
It grows, to be conducive to intestinal eubiosis.The bacillus can be by generating the stimulation such as antibody and raising macrophage activity
It is immune, enhance immunity of organisms and premunition.Compared with other strains, bacillus can form gemma in extreme environment,
Have many advantages, such as high temperature resistant, anti-extrusion and acid and alkali-resistance.The bacillus can selected from lichens spore bacillus, bacillus subtilis,
At least one of bacillus cereus, Japan bacillus etc., particularly preferably bacillus subtilis.The bacillus powder
Viable bacteria concentration be preferably 0.5 × 1010-3×1010CFU/g, more preferably 1.5 × 1010-2.0×1010CFU/g.In addition, with
On the basis of the total weight of the fullerene feed for pet additive, the content of the bacillus powder is preferably 0.5-8wt%, more
Preferably 2-6wt%.
Preferably, the rush digestive pharmaceutical is endothelium corneum gigeriae galli.Endothelium corneum gigeriae galli can either lure pet to feed, and can be with stomach invigorating, promotion
Pet digests and assimilates, so that excrement free from extraneous odour, improves immunity of pets.
Excipient can also be contained in the fullerene feed for pet additive.The excipient is also referred to as adhesive, is
Referring to itself has viscosity, and materials from bonding can be made at the substance of particle.Still sticking substance, referred to as drying are used under drying regime
Adhesive.The excipient can be natural polymer, or synthetic polymer.Wherein, the natural polymer can be with
For starch (such as starch slurry, modified starch, pregelatinized starch), carboxyrnethyl starch sodium, sugar, (such as sucrose, can be with Icing Sugar, syrup etc.
Form use), Arabic gum, at least one of tragacanth and gelatin.The synthetic polymer can be polyvinylpyrrolidine
At least one of ketone (PVP), methylcellulose, carboxymethyl cellulose, ethyl cellulose and hydroxypropyl cellulose.In addition, institute
The dosage for stating excipient accounts for the 1-10wt% of fullerene feed for pet additive total weight.
The preparation method of the fullerene feed for pet additive provided by the invention include by the fullerene microcapsule powder,
Vitamin, mineral trace element liquid, DL- METHIONINE, bacillus powder and rush digestive pharmaceutical and the mixing of optional excipient are equal
Even, granulation, sieving.A kind of specific embodiment according to the present invention, the preparation method of the fullerene feed for pet additive
Include: that (1) prepares mineral trace element liquid: by copper sulphate, zinc sulfate, manganese sulfate, potassium iodide, chelate iron, ammonium dihydrogen phosphate,
Cobalt chloride, sodium selenite are added to the water dilution and obtain mineral trace element liquid, and the dosage of each substance makes every 100mL minerals
Contain copper 0.41-0.68mg, zinc 200-250mg, manganese 16.12-21mg, iodine 10-15.5mg, iron 150- in liquid microelement
200mg, phosphorus 45-86mg, cobalt 0.36-0.80mg, selenium 2-3mg；(2) it prepares endothelium corneum gigeriae galli powder: endothelium corneum gigeriae galli being crushed, mistake
40-80 mesh, screenings is sterilized, the endothelium corneum gigeriae galli powder to be sterilized；(3) by fullerene microcapsule powder, vitamin, mineral
Matter liquid microelement, DL- METHIONINE, bacillus powder, endothelium corneum gigeriae galli powder and optional excipient are uniformly mixed, are granulated, mistake
Sieve, screenings is fullerene feed for pet additive.Wherein, the mixing can be carried out using three-dimensional mixer, mixing
Temperature can be room temperature, and the mixed time can be 10-15min.The granulation can carry out in boiling granulator.The mistake
Mesh size used by sieving can be 0.4-0.6mm.
In addition, the present invention also provides a kind of feeds, wherein added in the feed containing above-mentioned fullerene feed for pet
Agent.In addition, the content of the fullerene feed for pet additive is preferably 1-3wt% on the basis of the total weight of the feed.
Feed provided by the invention can be by the way that the fullerene feed for pet additive pellet to be added in basal feed
It obtains, granulation, dry, whole grain after each component of the fullerene feed for pet additive can also being mixed with basal feed
It obtains.
Feed and feed addictive provided by the invention are suitable for the cultivation to pig, cat, dog, rabbit etc..
The present invention using fullerene microcapsule powder as main component, with vitamin, mineral trace element liquid, DL- METHIONINE,
Bacillus powder, rush digestive pharmaceutical etc. cooperatively form new feed addictive, on the one hand utilize the multiple excellent properties of fullerene, improve
The activating cell of pet maintains pet health skin, improves the fur color of pet, reduces pet and drains peculiar smell；On the other hand
By the coordinated effect of above several components, the cost of feed addictive itself can not only be reduced, but also can be improved
The immunity and disease resistance of pet reduce the illness rate of pet, promote pet gastrointestinal disturbances, adjust stomach anti-diarrhea.This hair
The beneficial effect of bright acquirement is embodied in the following aspects:
(1) pet health skin is maintained, the fur color of pet is improved, pet is reduced and drains peculiar smell；
(2) impaired intestinal tract immune system is repaired, body inoxidizability is improved, reduces oxidative stress；
(3) profitable strain is supplemented, gastrointestinal disturbances are promoted, adjusts stomach anti-diarrhea；
(4) immunity and disease resistance for improving pet, reduce the illness rate of pet.
Detailed description of the invention
Fig. 1 is the microstructure schematic diagram of fullerene microcapsule powder provided by the invention.
Specific embodiment
The embodiment of the present invention is described below in detail, the examples of the embodiments are intended to be used to explain the present invention, and cannot
It is interpreted as limitation of the present invention.In the examples where no specific technique or condition is specified, described according to the literature in the art
Technology or conditions or carried out according to product description.Reagents or instruments used without specified manufacturer is that can lead to
Cross the conventional products of commercially available acquisition.
Preparation example 1: the preparation of fullerene oil solution
Accurate 100g nutrition compounds oily (olive oil, linseed oil, shinyleaf yellowhorn oil weight ratio are referred to as 5:3:2) and 0.3g fowler
Alkene C60, the above raw material is poured into and carries out ball milling in ball grinder, the transferred product after ball milling is subjected to 8000r/min into centrifugal bottle
It is centrifuged 1h, by the product after centrifugation by (0.5 μm) progress bacteria removing of filter plant, products obtained therefrom is fullerene after degerming
Nutrition compounds oil solution.
Preparation example 2: the preparation of fullerene oil solution
It is accurate to claim 100g olive oil and 0.15g fullerene C60, the above raw material is poured into and carries out ball milling in ball grinder, by ball milling
Transferred product afterwards carries out 7000r/min centrifugation 1.5h into centrifugal bottle, and the product after centrifugation is passed through filter plant (0.5 μm)
Bacteria removing is carried out, products obtained therefrom is fullerene olive oil solution after degerming.
Preparation example 3: the preparation of fullerene oil solution
It is accurate to claim 100g Seabuckthorm Seed Oil and 0.12g fullerene C70, the above raw material is poured into and carries out ball milling in ball grinder, by ball
Transferred product after mill carries out 6500r/min centrifugation 2h into centrifugal bottle, and the product after centrifugation is passed through filter plant (0.5 μm)
Bacteria removing is carried out, products obtained therefrom is fullerene sea-buckthorn oil solution after degerming.
Preparation example 4: the preparation of fullerene oil solution
It is accurate to claim 100g soybean oil and 0.08g fullerene C70, the above raw material is poured into and carries out ball milling in ball grinder, by ball milling
Transferred product afterwards carries out 6000r/min centrifugation 2.5h into centrifugal bottle, and the product after centrifugation is passed through filter plant (0.5 μm)
Bacteria removing is carried out, products obtained therefrom is fullerene soybean oil solution after degerming.
The formula of fullerene microcapsule powder is as shown in table 1 in embodiment 1-4:
Each raw material usage (wt%) in 1 embodiment 1-4 of table
| Project | Fullerene oil solution | Wall material | Food emulsifier | Stabilizer | Glidant |
| Embodiment 1 | 50 | 46 | 2 | 1 | 1 |
| Embodiment 2 | 33.3 | 62.7 | 2 | 1 | 1 |
| Embodiment 3 | 25 | 71 | 2 | 1 | 1 |
| Embodiment 4 | 50 | 47 | 1 | 0.5 | 1.5 |
Embodiment 1: the preparation of fullerene microcapsule powder
Raw material: it is shown in Table 1
Preparation method: under the conditions of 60 DEG C, by the maltodextrin (wall material) of 46wt%, casein sodium (the edible cream of 2wt%
Agent), the silica (glidant) of the dipotassium hydrogen phosphate (stabilizer) of 1wt% and 1wt% plus distilled water dissolution is mixed,
And fullerene nutrition compounding oil solution (being obtained by preparation example 1) that 50wt% is added is made into emulsion.Under the conditions of 60 DEG C,
Emulsification pretreatment 5min under 11200rpm.Lotion after shearing is carried out high-pressure homogeneous 3 times with high pressure homogenizer immediately, homogenization pressure
In 30-35MPa, the lotion after homogeneous is spray-dried, inlet air temperature is 200 DEG C, and leaving air temp is 82 DEG C, obtains fowler
Alkene microcapsule powder, shown in microscopic appearance Fig. 1.The grain diameter that can be seen that the fullerene microcapsule powder from the result of Fig. 1 is 5-20
μm, internal is hollow spherical shape or ellipse, this is because there is bubble inside particle in quick formed in product casing,
When the temperature of particle is more than the vapourizing temperature of surrounding moisture, the steam pressure inside particle is more than the pressure of ambient enviroment, outside
Shell will expand.In addition, the fullerene microcapsule powder shape is spherical in shape or oval, surface is smooth, fine and close, flawless, some
Grain surface is slightly recessed and shrinkage, this is specific to spray drying processing technology.
Embodiment 2: the preparation of fullerene microcapsule powder
Raw material: it is shown in Table 1
Preparation method: under the conditions of 60 DEG C, the casein sodium of the maltodextrin (wall material) of 62.7wt%, 2wt% is (edible
Emulsifier), the silica (glidant) of the dipotassium hydrogen phosphate (stabilizer) of 1wt% and 1wt% plus distilled water be mixed it is molten
Solution, and the fullerene olive oil solution (being obtained by preparation example 2) that 33.3wt% is added is made into emulsion.Under the conditions of 60 DEG C,
Emulsification pretreatment 5min under 11200rpm.Lotion after shearing is carried out high-pressure homogeneous 3 times with high pressure homogenizer immediately, homogenization pressure
In 30-35MPa, the lotion after homogeneous is spray-dried, inlet air temperature is 200 DEG C, and leaving air temp is 82 DEG C, obtains fowler
Alkene microcapsule powder, partial size are 100-200 μm.
Embodiment 3: the preparation of fullerene microcapsule powder
Raw material: it is shown in Table 1
Preparation method: under the conditions of 60 DEG C, by the maltodextrin (wall material) of 71wt%, casein sodium (the edible cream of 2wt%
Agent), the silica (glidant) of the dipotassium hydrogen phosphate (stabilizer) of 1wt% and 1wt% plus distilled water dissolution is mixed,
And the fullerene Seabuckthorm Seed Oil solution (being obtained by preparation example 3) that 25wt% is added is made into emulsion.Under the conditions of 60 DEG C,
Emulsification pretreatment 5min under 11200rpm.Lotion after shearing is carried out high-pressure homogeneous 3 times with high pressure homogenizer immediately, homogenization pressure
In 30-35MPa, the lotion after homogeneous is spray-dried, inlet air temperature is 200 DEG C, and leaving air temp is 82 DEG C, obtains fowler
Alkene microcapsule powder, partial size are 225-305 μm.
Embodiment 4: the preparation of fullerene microcapsule powder
Raw material: it is shown in Table 1
Preparation method: 9.4wt% soybean protein isolate (wall material) is dissolved with distilled water, at 80 DEG C of temperature control magnetic stirring apparatus
It is cooling after managing 30min；Silica (glidant) steaming of the sodium carboxymethylcellulose (stabilizer) and 1.5wt% of 0.5wt%
Distilled water dissolution, then by 37.6% maltodextrin (wall material) and above-mentioned soybean protein isolate solution, sodium carboxymethylcellulose and two
The mixed solution of silica stirs and evenly mixs, and 1% is added into the fullerene soybean oil solution (being obtained by preparation example 4) of 50wt%
Lecithin (food emulsifier) dissolves lecithin sufficiently with glass bar stirring, the above feed liquid is mixed, and
Emulsification pretreatment 5min is carried out under 11200rpm.Lotion after shearing is carried out high-pressure homogeneous 3 times with high pressure homogenizer immediately, homogeneous
Lotion after homogeneous is spray-dried by pressure in 35MPa, and inlet air temperature is 220 DEG C, and leaving air temp is 80 DEG C, is obtained rich
Alkene microcapsule powder is strangled, partial size is 310-400 μm.
Dosage of each component (wt%) in 2 fullerene feed for pet additive of table
| Project | Fullerene microcapsule powder | Multi-vitamins | Mineral trace element liquid | DL- METHIONINE | Bacillus powder | Endothelium corneum gigeriae galli |
| Embodiment 5 | 60 | 20 | 2 | 10 | 6 | 2 |
| Embodiment 6 | 65 | 18 | 0.5 | 12 | 4 | 0.5 |
| Embodiment 7 | 70 | 16 | 1.5 | 8 | 3 | 1.5 |
| Embodiment 8 | 80 | 12 | 0.5 | 4 | 3 | 0.5 |
Embodiment 5: the preparation of fullerene feed for pet additive
Formulation dosage: 2 are shown in Table
Preparation method: (1) mineral trace element liquid is prepared: by copper sulphate, zinc sulfate, manganese sulfate, potassium iodide, chelating
Iron, ammonium dihydrogen phosphate, cobalt chloride, sodium selenite are added to the water dilution and obtain mineral trace element liquid, and the dosage of each substance makes
It obtains and contains copper 0.41mg, zinc 250mg, manganese 21mg, iodine 15.5mg, iron 200mg, phosphorus in every 100mL mineral trace element liquid
86mg, cobalt 0.80mg, selenium 3mg.(2) endothelium corneum gigeriae galli is crushed, crosses 40 meshes, screenings is endothelium corneum gigeriae galli powder, by gained
Endothelium corneum gigeriae galli powder sterilizes, the endothelium corneum gigeriae galli powder to be sterilized.(3) by fullerene microcapsule powder (being made by embodiment 1), compound
Vitamin (being made of 10wt% vitamin A, 0.5wt% vitamin B1,3.5wt% vitamin B6 and 6wt% vitamin D),
Mineral trace element liquid, DL- METHIONINE, sterilizing endothelium corneum gigeriae galli powder after weighing proportionally, mixed using V-arrangement mixing machine
Uniformly, incorporation time 10min；It is granulated after being uniformly mixed through boiling granulator, the powder that average grain diameter is 0.4mm is made
Grain, obtained powder sieving, (viable bacteria concentration is 2 × 10 with bacillus subtilis powder after sieving10CFU/g, similarly hereinafter) mixing to get
Fullerene livestock and poultry pet additive, is denoted as ST-1.
Embodiment 6: the preparation of fullerene feed for pet additive
Formulation dosage: 2 are shown in Table
Preparation method: (1) mineral trace element liquid is prepared: by copper sulphate, zinc sulfate, manganese sulfate, potassium iodide, chelating
Iron, ammonium dihydrogen phosphate, cobalt chloride, sodium selenite are added to the water dilution and obtain mineral trace element liquid, and the dosage of each substance makes
It obtains and contains copper 0.68mg, zinc 200mg, manganese 16.21mg, iodine 10mg, iron 150mg, phosphorus 45mg, cobalt 0.36mg in every 100mL liquid,
Selenium 2mg.(2) endothelium corneum gigeriae galli is crushed, crosses 50 meshes, screenings is endothelium corneum gigeriae galli powder, and gained endothelium corneum gigeriae galli powder is carried out
Sterilizing, the endothelium corneum gigeriae galli powder to be sterilized.(3) by fullerene microcapsule powder (being made by embodiment 2), multi-vitamins (by 9wt%
Vitamin A, 2wt% vitamin B1,2wt% vitamin B6 and 5wt% vitamin D composition), mineral trace element liquid, DL-
Methionine, sterilizing endothelium corneum gigeriae galli powder after weighing proportionally, mix uniformly using V-arrangement mixing machine, incorporation time is
15min；It is granulated after being uniformly mixed through boiling granulator, the powder that average grain diameter is 0.5mm, obtained powder mistake is made
Sieve, mixes to get fullerene livestock and poultry pet additive with bacillus subtilis powder after sieving, is denoted as ST-2.
Embodiment 7: the preparation of fullerene feed for pet additive
Formulation dosage: 2 are shown in Table
Preparation method: (1) mineral trace element liquid is prepared: by copper sulphate, zinc sulfate, manganese sulfate, potassium iodide, chelating
Iron, ammonium dihydrogen phosphate, cobalt chloride, sodium selenite are added to the water dilution and obtain mineral trace element liquid, and the dosage of each substance makes
It obtains and contains copper 0.54mg, zinc 220mg, manganese 18.15mg, iodine 12.8mg, iron 160mg, phosphorus 67mg, cobalt in every 100mL liquid
0.52mg, selenium 2.5mg.(2) endothelium corneum gigeriae galli is crushed, crosses 60 meshes, screenings is endothelium corneum gigeriae galli powder, by gained endothelium corneum gigeriae galli
Powder sterilizes, the endothelium corneum gigeriae galli powder to be sterilized.(3) by fullerene microcapsule powder (being made by embodiment 3), multi-vitamins
(being made of 8wt% vitamin A, 1wt% vitamin B1,1wt% vitamin B6 and 6wt% vitamin D), the micro member of minerals
Plain liquid, DL- METHIONINE, sterilizing endothelium corneum gigeriae galli powder after weighing proportionally, mix uniformly using V-arrangement mixing machine, when mixing
Between be 10min；It is granulated after being uniformly mixed through boiling granulator, the powder that average grain diameter is 0.6mm, obtained powder is made
Sieving, mixes to get fullerene livestock and poultry pet additive with bacillus subtilis powder after sieving, is denoted as ST-3.
Embodiment 8: the preparation of fullerene feed for pet additive
Formulation dosage: it is shown in Table 1
Preparation method: (1) mineral trace element liquid is prepared: by copper sulphate, zinc sulfate, manganese sulfate, potassium iodide, chelating
Iron, ammonium dihydrogen phosphate, cobalt chloride, sodium selenite are added to the water dilution and obtain mineral trace element liquid, and the dosage of each substance makes
It obtains and contains copper 0.55mg, zinc 210mg, manganese 19.00mg, iodine 15.0mg, iron 190mg, phosphorus 82mg, cobalt in every 100mL liquid
0.77mg, selenium 2.3mg.(2) endothelium corneum gigeriae galli is crushed, crosses 80 meshes, screenings is endothelium corneum gigeriae galli powder, by gained endothelium corneum gigeriae galli
Powder sterilizes, the endothelium corneum gigeriae galli powder to be sterilized.(3) by fullerene microcapsule powder (being made by embodiment 4), multi-vitamins
(being made of 10wt% vitamin A, 0.5wt% vitamin B1,0.5wt% vitamin B6 and 1wt% vitamin D), minerals
Liquid microelement, DL- METHIONINE, sterilizing endothelium corneum gigeriae galli powder after weighing proportionally, mix uniformly using V-arrangement mixing machine,
Incorporation time is 15min；It is granulated after being uniformly mixed through boiling granulator, the powder that average grain diameter is 0.8mm is made, obtains
Powder sieving, mix after sieving with bacillus subtilis powder to get fullerene livestock and poultry pet additive, be denoted as ST-4.
Comparative example 1: the preparation of reference feed for pet additive
Feed for pet additive is prepared according to the method for embodiment 5, unlike, by fullerene microcapsule powder using identical heavy
The prebiotics substitution for measuring part, obtains reference feed for pet additive, is denoted as DST-1.
Comparative example 2: the preparation of reference feed for pet additive
Feed for pet additive is prepared according to the method for embodiment 5, unlike, by bacillus subtilis powder using identical
The prebiotics of parts by weight substitute, and obtain reference feed for pet additive, are denoted as DST-2.
Test example
1, experimental animal and grouping
Select physically well develop, weight is close, 12 the pet cat more than monthly age 105 of bouncing, according to weight and property
Other ratio phase approximately principle, 21 groups of test point, every group 5, four groups of test groups, one group of control group, two groups of reference groups.It is each to repeat 2 groups,
Feeding experiment is carried out, results are averaged.
2, daily ration is tested
Control group fed basal diet, test group feed basal diet+fullerene pet as made from embodiment 5~8 and raise
Feed additives ST-1~ST-4, reference group feed basal diet+by comparative example 1~2 prepare feed for pet additive DST-1~
DST-2.Wherein, the formula of basal diet are as follows: fish meal, carrot, beef liver, chicken meal, oat, edible oil, various vitamins and mine
Substance.
3, feeding management
It is all to be raised under the same environment for examination pet cat, identical feeding and management method is taken, by special messenger raising
Management.5d was raised with basal diet before on-test, adapts it to test daily ration and feeding environment.Expelling parasite is carried out before test, and
Routinely inoculation vaccine, after preliminary experiment, on an empty stomach by only weighing, raise as starting weight into formal test in the morning
Phase 1 month.The scale of feeding of feed for pet additive ST-1~ST-4 and DST-1~DST-2 are as follows: every cat scale of feeding is daily
The one thousandth of its weight is to 3/1000ths.Daily early, middle and late breakfast, lunch and dinner, basal diet metering is quantity-unlimiting, to food to have enough as original
Then, guarantee sufficient cleaning drinking-water, sweep animal house daily, rinse 1 time within every 2~3 days, disinfection 1 time per week.Cat is observed daily
Feeding, drinking-water, stool colour and incidence, and carry out corresponding record.
4, experimental data processing
Arrange with after primary Calculation using Excel, carries out single factor test side with SPSS statistical software general linear model
Difference analysis, DuncanShi method Multiple range test.Wherein, data are indicated with average value ± standard error, using P < 0.05 as significant difference
Property judgment criteria, is analyzed using regression analysis.
5, test result
(1) measurement of growth performance
Respectively at the weight of 30 days front and back measurement pet cats, the weight gain of pet cat is calculated.It records daily defecation simultaneously, adopt
Appetite and activity situation, wherein appetite and activity are measured with ten point system, feed intake is more, the more big then score of activity more
It is high.The coat compliance and brightness of pet cat are checked after the test, wherein compliance is with the consistency in coat appearance direction
With feel comprehensive descision, brightness is using natural light as light source and using coat brightness as standard.The coat compliance of pet cat, light
Brightness is measured with ten point system, and coat is brighter, more submissive then score is higher.Test result is shown in Table 3.
The testing index of 3 pet cat growth performance of table
As shown in Table 3, control group, test group ST-1~ST-4, reference group DST-1~DST-2 pet cat the method for double differences that increases day by day
Different not significant (P > 0.05), but test group and reference group can improve the daily gain of pet cat.In defecation, appetite, activity, fur
Compliance and brightness, test group have significant difference compared with the control group, and poor without conspicuousness compared with reference group DST-2
It is different, but have significant difference compared with the reference group DST-1 for being not added with fullerene microcapsule powder.And the daily gain of reference group DST-1,
Defecation, appetite, activity, fur compliance and brightness increase compared with the control group, but difference is not significant.
(2) fullerene feed for pet additive influences pet cat enteral bacterium
At random from control group, test group (ST-1), reference group (DST-1) each repetition in select 3 per rectums and take
Pet cat excrement is then placed in sterile chamber and counts for intestinal flora culture.The measurement of microbe quantity in excrement: aseptic area
Excrement 1.0g selects 10 with 0 times of ratio of two term dilution of phosphate buffer 1-4The dilution of g/mL is inoculated in various selectivity cultures
Base, if 3 repetitions.Culture medium and condition of culture such as the following table 4.Logarithm (the 1CFU/ of test result bacterium number in every gram of excrement
G) it indicates, concrete outcome is shown in Table 5.
4 culture medium of table and condition of culture
| Relevant bacteria species | Culture medium and dilution medium | Condition of culture |
| Bifidobacterium | BLB | 37 DEG C, 72h, anaerobism |
| Escherichia coli | EMB | It is 37 DEG C, for 24 hours, aerobic |
| Staphylococcus | SP | It is 37 DEG C, for 24 hours, aerobic |
| Bacillus acidi lactici | LBS | 37 DEG C, 48h, anaerobism |
| Big enterococcus | Enterococcus agar | 37 DEG C, 48h is aerobic |
5 pet cat enteral bacterium type and content of table
Note: same line number shoulder, which is marked with different capitalization English letters, indicates that difference is extremely significant (P < 0.01), there is different small letters
Letter indicates significant difference (P<0.05), and no upper case or lower case letter indicates that difference is not significant (P>0.05), similarly hereinafter.
As shown in Table 5, before the test, test group and reference group Bifidobacterium, Escherichia coli, staphylococcus, Bacillus acidi lactici
With big enterococcus and control group without significant difference (P > 0.05)；After the end of the test, test group and reference group Bacillus acidi lactici quantity
Extremely significant to be higher than control group (P < 0.01), Escherichia coli quantity is extremely significant to be lower than control group (P < 0.01), and bifidobacteria is aobvious
It writes and is higher than control group (P < 0.05), staphylococcus and big enterococcus are substantially less than control group (P < 0.05).
(3) measurement of physiological and biochemical index
1. at random from control group, test group, reference group each repetition in select 3 progress tail veins and take blood, it is quiet at 4 DEG C
After setting 3h, 4000r/min is centrifuged 10min, takes upper serum, -20 DEG C of preservations.Sample send limited in Wuhan Seville's biotechnology
Company measures every blood parameters, Immunoglobulin in Serum IgA, IgG, IgM and benefit using full-automatic biochemical instrument
Body C3, C4 content is measured using Immunity transmission turbidity；FT3 (triiodo thryonine), FT4 (free first shape in serum
Parathyrine) content use radioimmunology, measurement is counted by radio-immunity on immune counter.Test result is shown in Table 6.
2. at random from control group, test group, reference group each repetition in select 3 progress tail veins and take blood, blood is adopted
It is poured into rapidly after out in the anticoagulant blood-collecting pipe added with anti-coagulants, and is measured in whole blood and drenched using Full automatic animal cellanalyzer
Bar cell number, hemoglobin cell number, neutrophil leucocyte number, total white blood cells, Erythrocytes.Test result is shown in Table 6.
As shown in Table 6, test group ST-1~ST-4, reference group DST-2 blood lymphocytes quantity compared with the control group
There were significant differences (P<0.05), and difference is not significant (P>0.05) compared with the control group by reference group DST-1；Test group ST-1~
ST-4, reference group DST-2 blood neutrophil number have compared with the control group extremely significant difference (P < 0.01), and reference group
Difference is not significant (P > 0.05) compared with the control group by DST-1；But total white blood cells, Erythrocytes and hemoglobin are not shown
Writing influences (P > 0.05).IgA is respectively increased compared with the control group by test group ST-1~ST-4, reference group DST-1~DST-2
30.30%, 37.88%, 40.91%, 39.39%, 7.58%, 24.24%；IgM has been respectively increased 34.48%, 36.21%,
41.38%, 39.65%, 6.90%, 18.96%；Triiodo thryonine FT3 has been respectively increased 13.04%, 10.14%,
13.04%, 11.59%, 2.90%, 8.69%.It test group, the Complement C_3 of reference group, C4, free thyroxine FT4 and compares
Group is not significant (P > 0.05) compared to difference, but increases.
Influence of the 6 fullerene feed for pet additive of table to immune indexes in pet cat blood
For human and animal, system of defense most important for pathogen is immune system.Immune organ (bone
Marrow, thymus gland, spleen etc.), immunocyte (lymphocyte, monocyte, macrophage, neutrophil leucocyte, basophilic granulocyte,
Eosinophil) and immune factor (immunoglobulin, complement) constitute the immune system of humans and animals.In immune response
In the process, lymphocyte plays central role (LYM), and which reflects the degree of immune function and neutrophil leucocyte non-
It is played an important role in specific immune system, it is directed to pathogenic microorganism in vivo, especially prevents suppurative bacterium from invading
Occupied in entering it is the first (Zuo Zhaoyun, 2011；Zhao Xu, 2011).This test result shows: adding the present invention in basal diet and provides
Fullerene feed for pet additive, it is lymphocyte quantity, neutrophil leucocyte number, total white blood cells in pet cat blood, red
Total number of cells and hemoglobin cell number are intended to be higher by control group.
Immunoglobulin is the protection factor of humoral immunity, can protect body from extraneous pathogen or other nocuousness
The attack of molecule.IgA is the endocrine main immunoglobulin of body, is rejected to mucomembranous surface and plays antibacterial action, antiviral
Immunoglobulin IgG neutralize a toxin it made to lose toxicity, especially participate in humoral immunity, IgM infect in vivo after by
Pathogen by complement in conjunction with dissolution play the role of antipathogen infection (Chen Xiaobo etc., 2002；Cao Xuetao, 2013).This examination
Test the result shows that: add fullerene feed for pet additive provided by the invention in basal diet, be immunized in pet cat blood
Difference is extremely significant (P < 0.01) compared with the control group by globulin IgA, IgM, and difference is not compared with the control group for Immunoglobulin IgG
Significantly (P > 0.05), but increase.
Thyroxine (FT3, FT4) is a kind of hormone of wide participation nutrient metabolism, has with growth hormone and coordinates
Effect, plays adjustment effect to growth, to promote the growth and development of pet.In this test, test group triiodo first gland original ammonia
Sour FT3 significant difference compared with the control group, and difference is not significant compared with the control group by free thyroxine FT4, but is mentioned
It is high.This test result shows: fullerene feed for pet additive provided by the invention can promote body by the effect of thyroxine
The mobilization and decomposition of rouge, promote the growth of pet, this is consistent with the test result in this test in relation to growth performance, complement
Refer to an albuminoid of similar enzymatic activity, can assist and supplement specific antibody, mediated immunity bacteriolyze, haemocylolysis.It is anti-
Body C3 is the core component of system, and C4 can participate in adjusting complement activation, neutralize a toxin and prevent immune complex
Deposition.In this test, Complement C_3, C4 difference is not significant but all higher than the concentration of control group.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, it can be combined in any appropriate way.In order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. a kind of fullerene feed for pet additive, which is characterized in that contain fowler in the fullerene feed for pet additive
Alkene microcapsule powder, vitamin, mineral trace element liquid, DL- METHIONINE, bacillus powder and rush digestive pharmaceutical, and with the fowler
On the basis of the total weight of alkene feed for pet additive, the content of the fullerene microcapsule powder is 20-90wt%, the vitamin
Content is 5-35wt%, and the content of the mineral trace element liquid is 0.01-10wt%, and the content of the DL- METHIONINE is
0.5-20wt%, the content of the bacillus powder are 0.01-10wt%, and the content for promoting digestive pharmaceutical is 0.01-5wt%.
2. fullerene feed for pet additive according to claim 1, which is characterized in that contain in the fullerene microcapsule powder
There are fullerene compound, nutrition compounding oil, food emulsifier and wall material；
Preferably, on the basis of the total weight of the fullerene microcapsule powder, the fullerene compound and nutrition compound oil
Total weight content is 10-80wt% and the weight content of the fullerene compound is 0.1-5wt ‰, the food emulsifier
Weight content be 0.01-5wt%, the weight content of the wall material is 0.01-80wt%；
Preferably, on the basis of the total weight of the fullerene microcapsule powder, the weight content of the fullerene compound is 1-
5wt ‰, the weight content of the nutrition compounding oil are 50-70wt%, and the weight content of the food emulsifier is nutrition compounding
The 4-6wt% of fat weight content in oil, the weight content of the wall material are 29-49wt%；
Preferably, the partial size of the fullerene microcapsule powder is 5-500 μm.
3. fullerene feed for pet additive according to claim 2, which is characterized in that the fullerene compound choosing
From C60And its derivative, C70And its it derivative, fullerene metal derivative, fullerene containing oxygen derivative, repairs through organic compound
The fullerene of decorations or inclusion, through organic compound modified or inclusion at least one of fullerene derivate；Preferably, described
Oxygen atom in fullerene containing oxygen derivative is connected with the carbon atom on fullerene skeleton or is bonded with alkylidene chain, the warp
Organic compound in organic compound modified or inclusion fullerene and fullerene derivate is cyclodextrin and/or crown ether；
Nutrition compounding oil in edible oil, fat soluble vitamin, hydro carbons, fatty acid, higher alcohols and esters extremely
Few one kind；Preferably, the edible oil includes vegetable oil and animal oil, and the vegetable oil is selected from soybean oil, rapeseed oil, palm
Oil, olive oil, sunflower oil, shinyleaf yellowhorn oil, Seabuckthorm Seed Oil, corn oil, safflower oil, Purple Perilla Seed Oil, tea-seed oil, camellia seed oil,
Cottonseed oil, coconut oil, sesame oil, linseed oil, pumpkin seed oil, peony seed oil, hippophae rhamnoides fruit oil, walnut oil, Korean Pine seed, the moon are shown in
At least one of careless oil, safflower seed oil, borage oil, fiery flaxseed oil, salad oil, wheat-germ oil, avocado oil and Seabuckthorn Oil,
The animal oil is selected from least one of lard, butter, sheep oil, fish oil, house oil and turtle oil；Preferably, the hydro carbons is
Saualane and/or squalene；Preferably, the fatty acid is selected from oleic acid, linoleic acid, linolenic acid, conjugated linoleic acid, DHA, hard
At least one of resin acid, lauric acid, arachidonic acid and EPA；Preferably, the higher alcohols be selected from octyldodecanol,
At least one of laruyl alcohol, phytosterol, cholesterol and stearyl alcohol；Preferably, the esters are conjugated linoleic acid glycerol three
Ester and/or glyceryl linoleate；Preferably, the nutrition compounding oil is linseed oil, safflower seed oil, Purple Perilla Seed Oil, tea seed
Oil, sunflower oil, soybean oil, olive oil, pumpkin seed oil, evening primrose oil, borage oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, peony seeds
Oil, walnut oil, shinyleaf yellowhorn oil, Seabuckthorn Oil, fiery sesame oil, linoleic acid, linolenic acid, linoleic acid triglyceride, conjugated linoleic acid and altogether
Two or more combinations in conjugated linoleic acid triglycerides；
The food emulsifier is selected from sucrose fatty ester, polyglyceryl fatty acid ester, fatty acid glyceride, polyoxyethylene sorbitol
Alcohol acid anhydride aliphatic ester, casein sodium, lecithin, odium stearate, single glycerine organic acid aliphatic ester, glycine betaine, amino-acid salt,
Succinic acid fatty acid glyceride, stearoyl lactate, Tween-80, Arlacel-80, polyglycerol ester, propylene glycol fatty acid rouge and poly- mountain
At least one of pears alcohol fatty acid ester；Alternatively, the food emulsifier is the mixture of A or A and B, A is oligofructose, resists
Property dextrin, one of skimmed milk power or two kinds, B is casein sodium, list, diglycerine fatty acid ester, ocentyl succinic
In sodium starch, ascorbic acid, sodium ascorbate, phosphatide, natural VE, sodium tripolyphosphate and ascorbyl palmitate
It is a kind of；
The wall material is selected from maltodextrin, soybean protein isolate, Arabic gum, beta-cyclodextrin, starch, Whey Protein Concentrate, paste
Essence, corn syrup, gelatin, sodium carboxymethylcellulose, xanthan gum, agar, carragheen, chitosan, starch octenyl succinate anhydride,
Guar gum, seaweed glue, alginate, lactoprotein, casein, mucedin, gliadin, substitute of cocoa fat, caseinic acid,
Vegetable protein, lactose, sucrose, maltose, methylcellulose, ethyl cellulose, methylhydroxypropylcellulose, carboxymethyl cellulose
At least one of element, hydroxymethyl cellulose, hydroxypropyl cellulose, avicel cellulose and water-soluble dietary fiber；Preferably, institute
Wall material is stated as two kinds or three in soybean protein isolate, xanthan gum, converted starch, gelatin, carboxymethyl cellulose, maltodextrin
Kind or more mix.
4. fullerene feed for pet additive according to claim 2, which is characterized in that the grease of the nutrition compounding oil
Fatty acid proportion is saturated fatty acid: monounsaturated fatty acids: polyunsaturated fatty acid weight ratio is 1:(0.5-2): (0.5-
2), the polyunsaturated fatty acid Linoleic acid: linolenic acid by weight ratio is 1:(0.5-2)；
Preferably, the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid: monounsaturated fatty acids: how unsaturated
Fatty acid wt ratio is 1:(0.5-1.5): (0.5-1.5), the polyunsaturated fatty acid Linoleic acid: linolenic acid by weight ratio is
1:(0.5-1.5)；
It is highly preferred that the oil fatty acid ratio of the nutrition compounding oil is saturated fatty acid: monounsaturated fatty acids: more insatiable hungers
It is 1:1:1 with fatty acid wt ratio, the polyunsaturated fatty acid Linoleic acid: linolenic acid by weight ratio is 1:1.
5. fullerene feed for pet additive described in any one of -4 according to claim 1, which is characterized in that the fowler
Also contain stabilizer and/or glidant in alkene microcapsule powder；
Preferably, on the basis of the total weight of the fullerene microcapsule powder, the weight content of the stabilizer is 0.01-
20wt%, the weight content of the glidant are 0.01-2wt%；
Preferably, the stabilizer is selected from arabo-ascorbic acid and its salt, gallic acid and its derivative, gluconic acid, trimerization phosphorus
At least one in sour sodium, composite phosphate, dipotassium hydrogen phosphate, polyphosphate sodium, sodium metaphosphate, sodium carboxymethylcellulose and agar
Kind；
Preferably, the glidant is selected from silicate, stearate, molysite, phosphate, polysaccharide, talcum powder, calcium carbonate and two
At least one of zinc oxide；Preferably, the silicate is selected from silica, calcium silicates, lagoriolite, magnesium silicate and sial
At least one of sour sodium, the stearate in odium stearate, calcium stearate, aluminum stearate and zinc stearate at least
One kind, the molysite are ammonium iron citrate and/or cyanogen ferrisodium, and the phosphate is calcium phosphate and/or magnesium phosphate, the polysaccharide
For depolymerization starch and/or crystallite depolymerizing cellulose.
6. fullerene feed for pet additive described in any one of -4 according to claim 1, which is characterized in that the fowler
(1) or mode (2) are prepared alkene microcapsule powder in the following ways:
Mode (1):
It is oily mutually to prepare: the nutrition compounding oil is prepared by fatty acid proportion, it then will be molten after fullerene compound sterilizing
Solution is into nutrition compounding oil, at oily compound is compounded, the food emulsifier is dissolved into the oily compound of compounding later, is obtained
Oily phase；
Water phase preparation: the wall material is dissolved in hot water and obtains water phase；Preferably, the temperature of hot water is 60-80 DEG C；
Mixing sterilizing: gained water phase is mixed with oil and is stirred evenly, is then sterilized；
Homogeneous, spray drying: homogeneous, spray drying obtain fullerene microcapsule powder；
Mode (2):
The fullerene compound is dissolved in the nutrition compounding oil, fullerene oil solution is obtained；
By the fullerene oil solution, wall material, food emulsifier and selectively the stabilizer that contains and glidant mix, it is molten
Solution, dispersion, homogeneous, are made emulsion, and gained emulsion is carried out homogeneous, is later spray-dried homogeneous lotion；
Preferably, in mode (1) and mode (2), the mixing carries out in a shear condition, and the mixed condition includes temperature
Degree is 50-80 DEG C, shear rate 10000-15000rpm, time 2-10min；The pressure of the homogeneous is 30-35MPa,
Number is 2-5 times；The condition of the spray drying includes that inlet air temperature is 180-240 DEG C, and leaving air temp is 75-85 DEG C.
7. fullerene feed for pet additive described in any one of -4 according to claim 1, which is characterized in that
The vitamin contains vitamin A, vitamin B1, vitamin B6 and vitamin D；With fullerene feed for pet addition
On the basis of the total weight of agent, the content of the vitamin A is 3-15wt%, preferably 4-12wt%, is more preferably 8-10wt%,
The content of the vitamin B1 is 0.01-5wt%, preferably 0.1-5wt%, more preferably 0.5-2wt%, the vitamin B6
Content be 0.01-5wt%, preferably 0.1-5wt%, more preferably 0.5-2wt%, the content of the vitamin D is 1-
8wt%, preferably 2-6wt%, more preferably 3-6wt%；
Contain copper, zinc, manganese, iodine, iron, phosphorus, cobalt and selenium in the mineral trace element liquid, and minerals described in every 100mL are micro-
Copper content is 0.41-0.68mg, Zn content 200-250mg, manganese content 16.12-21mg in secondary element liquid, and content of iodine is
10-15.5mg, iron content 150-200mg, phosphorus content 45-86mg, cobalt content 0.36-0.80mg, Se content 2-
3mg；
The bacillus powder is in lichens spore bacillus, bacillus subtilis, bacillus cereus and Japan bacillus
At least one, preferably bacillus subtilis；The viable bacteria concentration of the bacillus powder is 0.5 × 1010-3×1010CFU/g；
The rush digestive pharmaceutical is endothelium corneum gigeriae galli.
8. fullerene feed for pet additive described in any one of -4 according to claim 1, which is characterized in that the fowler
Also contain excipient in alkene feed for pet additive；The excipient is selected from starch, carboxyrnethyl starch sodium, sugar, Arabic gum, Radix Astragali
In glue, gelatin, polyvinylpyrrolidone, methylcellulose, carboxymethyl cellulose, ethyl cellulose and hydroxypropyl cellulose extremely
Few one kind；On the basis of the total weight of the fullerene feed for pet additive, the content of the excipient is 1-10wt%.
9. the preparation method of fullerene feed for pet additive described in any one of claim 1-8, which is characterized in that should
Method includes that the fullerene microcapsule powder, vitamin, mineral trace element liquid, DL- METHIONINE, bacillus powder and rush disappear
Agent and optional excipient are uniformly mixed, are granulated, are sieved.
10. a kind of feed, which is characterized in that dote in the feed containing fullerene described in any one of claim 1-8
Object feed addictive；Preferably, on the basis of the total weight of the feed, the content of the fullerene feed for pet additive is
1-3wt%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2018102592878 | 2018-03-27 | ||
| CN201810259287.8A CN108497099A (en) | 2018-03-27 | 2018-03-27 | Fullerene be used to be prepared into the purposes of fullerene microcapsule powder |
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| CN201810259287.8A Pending CN108497099A (en) | 2018-03-27 | 2018-03-27 | Fullerene be used to be prepared into the purposes of fullerene microcapsule powder |
| CN201811123023.6A Pending CN110301483A (en) | 2018-03-27 | 2018-09-26 | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application |
| CN201811365700.5A Pending CN109258934A (en) | 2018-03-27 | 2018-11-16 | Application of the fullerene microcapsule powder as feed addictive |
| CN201811365699.6A Pending CN109258933A (en) | 2018-03-27 | 2018-11-16 | Fullerene feeding additive aquatic animal and preparation method thereof and feed |
| CN201811365406.4A Pending CN109258931A (en) | 2018-03-27 | 2018-11-16 | Fullerene additive for farm animal feed and preparation method thereof and feed |
| CN201811365697.7A Pending CN109258932A (en) | 2018-03-27 | 2018-11-16 | Fullerene feed for pet additive and preparation method thereof and feed |
| CN202210449776.6A Pending CN115024365A (en) | 2018-03-27 | 2018-11-16 | Application of fullerene to preparation of fullerene microcapsule powder and preparation method |
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| CN201810259287.8A Pending CN108497099A (en) | 2018-03-27 | 2018-03-27 | Fullerene be used to be prepared into the purposes of fullerene microcapsule powder |
| CN201811123023.6A Pending CN110301483A (en) | 2018-03-27 | 2018-09-26 | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application |
| CN201811365700.5A Pending CN109258934A (en) | 2018-03-27 | 2018-11-16 | Application of the fullerene microcapsule powder as feed addictive |
| CN201811365699.6A Pending CN109258933A (en) | 2018-03-27 | 2018-11-16 | Fullerene feeding additive aquatic animal and preparation method thereof and feed |
| CN201811365406.4A Pending CN109258931A (en) | 2018-03-27 | 2018-11-16 | Fullerene additive for farm animal feed and preparation method thereof and feed |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN108497099A (en) | 2018-09-07 |
| CN109258933A (en) | 2019-01-25 |
| CN109258931A (en) | 2019-01-25 |
| CN110301483A (en) | 2019-10-08 |
| CN109258934A (en) | 2019-01-25 |
| CN115024365A (en) | 2022-09-09 |
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