CN109222910A - Fluorescence detection device - Google Patents
Fluorescence detection device Download PDFInfo
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- CN109222910A CN109222910A CN201811182747.8A CN201811182747A CN109222910A CN 109222910 A CN109222910 A CN 109222910A CN 201811182747 A CN201811182747 A CN 201811182747A CN 109222910 A CN109222910 A CN 109222910A
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- detection device
- fluorescence detection
- light source
- laser source
- observation channel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- Heart & Thoracic Surgery (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to optical medical auxiliary instrument technical fields, are related to fluorescence detection device.Fluorescence detection device includes shell, light source bracket, laser source and observation channel；Light source bracket, laser source and observation channel are arranged in shell；Light source bracket is set in observation channel outer wall, and laser source is on light source bracket；Observation is provided with multiple detectors connecting with imager in channel.Shell is directly contacted with body tissue surface, the exciting light of body tissue surface reflection can be blocked by device itself, and the exciting light for penetrating body tissue is irradiated to fluorescence caused by ICG, but it can be penetrated in channel from device center, and it is received by fluorescence detector, body tissue surface reflection has been blocked to return the useless exciting light of fluorescence detection device, body tissue surface reflection has been blocked to return the useless exciting light of fluorescence detection device, avoid influence of a large amount of reflected excitation lights to picture, the signal-to-noise ratio for improving image, enhances image effect.
Description
Technical field
The present invention relates to optical medical auxiliary instrument technical fields, in particular to fluorescence detection device.
Background technique
Sentinel lymph node is the special lymph node in primary tumo(u)r drainage regional lymph nodes, is that lymph node occurs for primary tumo(u)r
Shift first necessary lymph node.The clinical application of sentinel lymph node biopsy makes the mammary gland that axillary gland does not shift
Carninomatosis people avoids axillary lymph node dissection, so as to avoid corresponding postoperative complication such as upper limb lymphedema etc., greatly mentions
The high quality of life of patient, therefore be concerned by people.
There are three types of methods at present to detect sentinel lymph node: blue dyes method, the method is more traditional, uses the indigo plants such as methylene blue
Color stain, effect is bad, and doctor is needed to have very long learning curve.(2) nucleic probe method, because being related to radioactive element,
There is certain radiation effects to human body, can cause environmental pollution simultaneously, use is also more troublesome, does not promote in clinic
It opens, and device systems are more expensive.(3) fluorescent penetrant method, this is a kind of newest detection method quickly, safe, uses fluorescence
Detection device watches indocyanine green (ICG) fluorescence, can be quickly found out sentinel lymph node, and be imaged over the display.
ICG vein or be subcutaneously injected into vivo after, rapidly and protein combine, ICG by 700-800nm exciting light photograph
Penetrate the fluorescence for generating 800-900nm.Because ICG fluorescence belongs near infrared light, human eye can not be observed directly, so needing fluorescence
Detection device is observed.Therefore fluorescent penetrant method image quality directly affects the judgement and operation effect of sentinel lymph node position
Fruit.
In sentinel lymph node biopsy operation, the lymph node position of most of patients is relatively deep, in noninvasive situation, uses
Conventional fluorescent detection device is difficult to observe the specific location of lymph node.It causes repeatedly to observe, and estimates lymph node position, make
At the cumbersome of operation and increase the fault possibility estimated.
Therefore it provides to become those skilled in the art to be solved important for a kind of good fluorescence detection device of imaging effect
Technical problem.
Summary of the invention
The purpose of the present invention is to provide a kind of fluorescence detection devices, to alleviate the technology of imaging effect difference in the prior art
Problem.
The embodiment of the invention provides a kind of fluorescence detection device, including shell, light source bracket, laser source and observation are logical
Road；
The light source bracket, the laser source and the observation channel are arranged in the shell；
The light source bracket is set in the observation channel outer wall, and the laser source is on the light source bracket；
Multiple detectors connecting with imager are provided in the observation channel；
The optical maser wavelength that the laser source issues is between 781-789nm.
The first possible embodiment provided in an embodiment of the present invention, wherein the optical maser wavelength that above-mentioned laser source issues
For 785nm.
Second of possible embodiment provided in an embodiment of the present invention, wherein above-mentioned light source bracket is in a ring.
The third possible embodiment provided in an embodiment of the present invention, wherein be provided with and be used in above-mentioned observation channel
Filter the optical filter of laser.
4th kind of possible embodiment provided in an embodiment of the present invention, wherein be provided with connection in above-mentioned observation channel
Seat, the filter are detachably connected with the attachment base.
5th kind of possible embodiment provided in an embodiment of the present invention, wherein above-mentioned laser source and the light source bracket
It is fixedly connected.
6th kind of possible embodiment provided in an embodiment of the present invention, wherein above-mentioned multiple laser sources are evenly spaced in
On the light source bracket.
7th kind of possible embodiment provided in an embodiment of the present invention, wherein be provided with below above-mentioned laser source light-blocking
Circle；
The axis of the light blocking ring is overlapped with the axis in the observation channel.
8th kind of possible embodiment provided in an embodiment of the present invention, wherein above-mentioned light blocking ring and the observation channel
It is detachably connected.
9th kind of possible embodiment provided in an embodiment of the present invention, wherein be provided on above-mentioned shell for controlling
The switch of the laser source opening and closing.
The utility model has the advantages that
The embodiment of the invention provides a kind of fluorescence detection device, including shell, light source bracket, laser source and observation are logical
Road；Light source bracket, laser source and observation channel are arranged in shell；Light source bracket is set in observation channel outer wall, laser source
On light source bracket；Observation is provided with multiple detectors connecting with imager in channel.When using fluorescence detection device, shell
Body is directly contacted with skin or body tissue surface, and the exciting light of such skin and other body tissue surface reflections can be by device
It itself is blocked, and the exciting light for penetrating skin or other body tissues is irradiated to fluorescence caused by ICG, it but can be from device
The observation channel of the heart is penetrated, and is received by fluorescence detector, and skin or body tissue surface reflection has been blocked to return fluorescence inspection
The useless exciting light of measurement equipment avoids influence of a large amount of reflected excitation lights to picture, improves the signal-to-noise ratio of image, enhance
Image effect.
Other features and advantages of the present invention will illustrate in the following description, also, partly become from specification
It obtains it is clear that understand through the implementation of the invention.The objectives and other advantages of the invention are in specification, claims
And specifically noted structure is achieved and obtained in attached drawing.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, and cooperate
Appended attached drawing, is described in detail below.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the cross-sectional view of fluorescence detection device provided in an embodiment of the present invention；
Fig. 2 is the bottom view of fluorescence detection device provided in an embodiment of the present invention.
Icon: 100- shell；200- light source bracket；300- laser source；400- observes channel；410- light blocking ring；
420- optical filter；430- attachment base；500- detector；600- body tissue.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise ", " axial direction ", " radial direction ", " circumferential direction " be orientation based on the figure or
Positional relationship is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning must
There must be specific orientation, be constructed and operated in a specific orientation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more of the features.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integral；It can be mechanical connect
It connects, is also possible to be electrically connected；It can be directly connected, can also can be in two elements indirectly connected through an intermediary
The interaction relationship of the connection in portion or two elements.It for the ordinary skill in the art, can be according to specific feelings
Condition understands the concrete meaning of above-mentioned term in the present invention.
The present invention is described in further detail below through specific implementation examples and in conjunction with the accompanying drawings.
With reference to shown in Fig. 1-Fig. 2:
The embodiment of the invention provides a kind of fluorescence detection devices, including shell 100, light source bracket 200, laser source 300
With observation channel 400；Light source bracket 200, laser source 300 and observation channel 400 are arranged in shell 100；Light source bracket
200 are set in observation 400 outer wall of channel, and laser source 300 is on light source bracket 200；Observation channel 400 in be provided with it is multiple with
The detector 500 of imager connection；The optical maser wavelength that laser source 300 issues is between 781-789nm.
The embodiment of the invention provides a kind of fluorescence detection devices, including shell 100, light source bracket 200, laser source 300
With observation channel 400；Light source bracket 200, laser source 300 and observation channel 400 are arranged in shell 100；Light source bracket
200 are set in observation 400 outer wall of channel, and laser source 300 is on light source bracket 200；Observation channel 400 in be provided with it is multiple with
The detector 500 of imager connection.When using fluorescence detection device, shell 100 and skin or 600 surface of body tissue are direct
The exciting light of contact, such skin and other 600 surface reflections of body tissue can be blocked by device itself, and penetrate skin
Or the exciting light of other body tissues 600 is irradiated to fluorescence caused by ICG, but can from device center channel 400
It is penetrated, and is received by fluorescence detector 500, skin or 600 surface reflection of body tissue has been blocked to return fluorescence detection device
Useless exciting light, avoid influence of a large amount of reflected excitation lights to picture, improve the signal-to-noise ratio of image, enhance image effect
Fruit improves the sensitivity of fluoroscopic image.
Specifically, being irradiated by laser of the optical maser wavelength between 781-789nm to IGG, fluorescence can be improved
Illumination effect further increases image effect.
Specifically, being provided with uniform light board below laser source 300, so that laser is uniform to the laser intensity of patient affected part, keep away
It is excessive to exempt from somewhere intensity of illumination, later period imaging is impacted.
Fluorescence detection device provided in this embodiment can increase picture contrast and Observational depth, promote observation effect.
Such as in the positioning operation of sentinel lymph node, since oxter fat is thicker, the specific location of lymph node is not often observed, it can only
By observing shallow-layer lymphatic vessel deduction lymph node position out of shape, the accuracy rate of sentinel lymph node position judgement can be reduced in this way, is increased
Add operation risk, just can observe the lymph node of deeper inside before surgery using the present apparatus, can accurately be positioned, reduces hand
Art risk, the safety to operation, convenience are significantly increased.
In the optinal plan of the present embodiment, the optical maser wavelength that laser source 300 issues is 785nm.
Specifically, the optical maser wavelength that laser source 300 issues is 785nm.
In the optinal plan of the present embodiment, light source bracket 200 is in a ring.
Specifically, light source bracket 200 is in a ring, when installing fluorescence detection device, observation channel 400 is plugged in light source branch
In frame 200.
When laser source 300 shines, light source is issued along observation channel 400, and the laser for avoiding laser source 300 from issuing is straight
It connects and enters in observation channel 400, the imaging in later period is impacted.
In the optinal plan of the present embodiment, the optical filter 420 being provided in channel 400 for filtering laser is observed.
It is 781-789nm's to wavelength by optical filter 420 specifically, being provided with optical filter 420 in observation channel 400
Laser is filtered, and further increases fluorescence imaging effect.
In the optinal plan of the present embodiment, observes and be provided with attachment base 430 in channel 400, filter and attachment base 430 can
Dismantling connection.
Specifically, being provided with attachment base 430 in observation channel 400, filter is removably arranged on attachment base 430,
Filter can be replaced as needed.
In the optinal plan of the present embodiment, laser source 300 is fixedly connected with light source bracket 200.
In the optinal plan of the present embodiment, multiple laser sources 300 are evenly spaced on light source bracket 200.
Uniformly arrangement is fixed on light source bracket 200 multiple laser sources 300.
In the optinal plan of the present embodiment, light blocking ring 410 is provided with below laser source 300；The axis of light blocking ring 410 and sight
The axis for examining channel 400 is overlapped.
Specifically, light blocking ring 410 is provided with below laser source 300, and when in use, the skin of light blocking ring 410 and patient
Or 600 surface of body tissue directly contacts, i.e., light-blocking band is adjacent to 600 surface of skin surface and body tissue, and such exciting light shines
The reflected light for being mapped to 600 surface of skin and body tissue is blocked by shell 100 and light blocking ring 410, and body tissue 600 is sent out
Fluorescence out can be collected by the detector 500 in observation channel 400, substantially reduce reflection compared to traditional device in this way
Into the laser of fluorescence detection device camera lens, picture contrast and Observational depth are increased；Pass through the setting of optical filter 420, mistake
Laser is filtered, so as to further increase picture contrast.
Fluorescence detection device in the prior art is needed when in use apart from patient's 5~30cm distance, laser source 300 with it is glimmering
Light sensing device is in same plane.In laser irradiation to skin, a part penetrates skin and enters the corresponding machine with fluorescer
Body tissue 600 after fluorescer is by the irradiation of exciting light, issues fluorescence, and the laser and fluorescer of such skin surface reflection are sent out
Fluorescence out can all be received together into observation fluorescence detection device, even if there is optical filter 420 to obstruct exciting light,
The presence of exciting light can not be completely cut off completely, certain interference can be carried out to picture.
In the optinal plan of the present embodiment, light blocking ring 410 is detachably connected with observation channel 400.
Specifically, the one end on light blocking ring 410 and patient skin basis is smooth and is easy to slide.
The vertical section of light blocking ring 410 is L-shaped, and the prominent shell 1001-3mm of light blocking ring 410 guarantees gear when in use
Aperture 410 and patient skin are in sealing contact, reduce laser reflection and enter observation channel 400.
In the optinal plan of the present embodiment, the switch for controlling the opening and closing of laser source 300 is provided on shell 100.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (10)
1. a kind of fluorescence detection device characterized by comprising shell, light source bracket, laser source and observation channel；
The light source bracket, the laser source and the observation channel are arranged in the shell；
The light source bracket is set in the observation channel outer wall, and the laser source is arranged on the light source bracket；
Multiple detectors connecting with imager are provided in the observation channel；
The optical maser wavelength that the laser source issues is between 781-789nm.
2. fluorescence detection device according to claim 1, which is characterized in that the optical maser wavelength that the laser source issues is
785nm。
3. fluorescence detection device according to claim 1, which is characterized in that the light source bracket is in a ring.
4. fluorescence detection device according to claim 1, which is characterized in that be provided in the observation channel for filtering
The optical filter of laser.
5. fluorescence detection device according to claim 4, which is characterized in that it is provided with attachment base in the observation channel,
The filter is detachably connected with the attachment base.
6. fluorescence detection device according to claim 1, which is characterized in that the laser source is fixed with the light source bracket
Connection.
7. fluorescence detection device according to claim 6, which is characterized in that multiple laser sources are evenly spaced in described
On light source bracket.
8. fluorescence detection device according to claim 1, which is characterized in that be provided with light blocking ring below the laser source；
The axis of the light blocking ring is overlapped with the axis in the observation channel.
9. fluorescence detection device according to claim 8, which is characterized in that the light blocking ring and the observation channel are removable
Unload connection.
10. -9 described in any item fluorescence detection devices according to claim 1, which is characterized in that be arranged on the shell useful
In the switch for controlling the laser source opening and closing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811182747.8A CN109222910A (en) | 2018-10-10 | 2018-10-10 | Fluorescence detection device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811182747.8A CN109222910A (en) | 2018-10-10 | 2018-10-10 | Fluorescence detection device |
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| CN109222910A true CN109222910A (en) | 2019-01-18 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111458321A (en) * | 2020-05-22 | 2020-07-28 | 南京诺源医疗器械有限公司 | Diagnostic system based on lesion site fluorescence feedback |
| CN111493827A (en) * | 2020-04-23 | 2020-08-07 | 南京诺源医疗器械有限公司 | Fluorescence radiography inspection system based on 785nm wavelength light source |
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Application publication date: 20190118 |