CN109170163A - A kind of high-efficiency feed additive containing bafillus natto - Google Patents
A kind of high-efficiency feed additive containing bafillus natto Download PDFInfo
- Publication number
- CN109170163A CN109170163A CN201811150140.1A CN201811150140A CN109170163A CN 109170163 A CN109170163 A CN 109170163A CN 201811150140 A CN201811150140 A CN 201811150140A CN 109170163 A CN109170163 A CN 109170163A
- Authority
- CN
- China
- Prior art keywords
- antibiotic
- bafillus natto
- feed
- natto
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of high-efficiency feed additives containing bafillus natto.The feed addictive contains bafillus natto and antibiotic, and the antibiotic is aureomycin, enramycin and/or flavomycoin.The present invention regard bafillus natto and appropriate antibiotics combination as feed addictive, the usage amount of antibiotic can be reduced, the biological transformation ratio of feed is significantly improved simultaneously, effectively inhibit the growth of pathogenic microorganism in enteron aisle, promote the growth of the probiotics such as Bifidobacterium, Bacillus acidi lactici, adjust the growth of host intestine normal flora, keep intestinal microecology balance, effectively prevent and control Animal diseases, reduce antibiotic residue in animal products, drug-resistant bacteria is reduced, culture efficiency is effectively improved, has a good application prospect.
Description
Technical field
The invention belongs to field of feed additive technology.Contain the efficient of bafillus natto more particularly, to a kind of
Feed addictive.
Background technique
In aquaculture, the abuse of antibiotic medicine causes medicament residue and a large amount of drug tolerant bacterias generate, knot
Fruit seriously hinder poultry, fowl, culture fishery healthy and sustainable development, buried for the health of food safety and consumer
Hidden danger, therefore it is extremely urgent to find safety, the Substitutes For Antibiotic of noresidue.
Biological feed additive comprising probiotics is a kind of very ideal Substitutes For Antibiotic, and probiotics is exploitation
The important foundation for the biological feed additive that quality is stable, effect is obvious, cost performance is high.
But there are the main Qualities of the following aspects for probiotics: (1) viable bacteria content is low；(2) moisture
One of an important factor for content is higher, this is influence probiotics quality；(3) not antibiotic-resistant；(4) to gastric acid and cholate
It is unstable, it is still active after causing only a small number of bacterial strains to enter enteron aisle, the required number of viable that plays a role is not achieved.Due to
These quality problems existing for probiotics, effect is often barely satisfactory, so that its application effect on animal is affected,
Limit the extensive use of probiotics.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the defect of the above-mentioned prior art and deficiencies, provide one kind and contain natto
The high-efficiency feed additive of bacillus is combined using bafillus natto and suitable antibiotic, can reduce making for antibiotic
Dosage, while the conversion ratio of feed is significantly improved, effectively inhibit harmful microbe growth in enteron aisle, promotes Bifidobacterium, cream
The growth of the anaerobic bacterias such as acidfast bacilli, promote host intestine normal flora growth, keep intestinal microecology balance, effectively prevention and
Animal diseases are controlled, and drug resistance will not be generated.
The object of the present invention is to provide a kind of high-efficiency feed additives containing bafillus natto.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of high-efficiency feed additive containing bafillus natto, containing bafillus natto and antibiotic, the antibiotic
For aureomycin, enramycin and/or flavomycoin.
With reference to the operation instruction of various antibiotic, general feeding additive amount is chosen, each drug dilution concentration that converts is C0, then
It chooses 0.5C0 and 2.0C0 and compares gradient, sterile water is used in dilution.Various antibiotic or chemical article additive amount generally make
Dosage is shown in Table 1.
Particularly preferably, when antibiotic is aureomycin, the amount ratio of bafillus natto and aureomycin is 20 L:10~15 μ
mg。
It is highly preferred that the amount ratio of bafillus natto and aureomycin is 20 μ L:12.5 when antibiotic is aureomycin
mg。
Preferably, when antibiotic is enramycin, the amount ratio of bafillus natto and enramycin be 20 μ L:10~
15 mg。
It is highly preferred that the amount ratio of bafillus natto and enramycin is 20 μ L when antibiotic is enramycin:
12.5 mg。
Preferably, when antibiotic is flavomycoin, the amount ratio of bafillus natto and flavomycoin be 20 μ L:40~
60mg。
It is highly preferred that the amount ratio of bafillus natto and flavomycoin is 20 μ L:50 mg when antibiotic is flavomycoin.
Wherein, above-mentioned bafillus natto is bacterium solution, and viable count is 1-2 × 106Cfu/ul~1-2 × 107cfu/μL。
The invention has the following advantages:
The present invention provides feed addictives associated with a kind of bafillus natto and appropriate antibiotics, can reduce making for antibiotic
Dosage, while the conversion ratio of feed is significantly improved, effectively inhibit harmful microbe growth in enteron aisle, promotes Bifidobacterium, cream
The growth of the anaerobic bacterias such as acidfast bacilli, promote host intestine normal flora growth, keep intestinal microecology balance, effectively prevention and
Animal diseases are controlled, and drug resistance will not be generated, culture efficiency is significantly improved, has a good application prospect.
Detailed description of the invention
Fig. 1 is the influence that antibiotic grows bafillus natto；Note: compared with the control group, * indicates the extremely significant (P of difference
< 0.01).
Specific embodiment
The present invention is further illustrated below in conjunction with Figure of description and specific embodiment, but embodiment is not to the present invention
It limits in any form.Unless stated otherwise, the present invention uses reagent, method and apparatus routinely try for the art
Agent, method and apparatus.
Unless stated otherwise, following embodiment agents useful for same and material are commercially available.
Bafillus natto used in following embodiment is bacterium solution, and viable count is 2 × 107cfu/μL。
The experiment of 1 bafillus natto Antibiotic Sensitivity of embodiment
1, experimental study bafillus natto is to antibiotic aureomycin, olaquindox, speed big fertilizer, Bacitracin Zinc, colistin sulfate, grace
Draw the sensibility of mycin, flavomycoin.
2, result is as shown in Figure 1:
(1) aureomycin has no significant effect the growth of bafillus natto, can be with compatible use.
(2) enramycin is in 0.5C0Under dosage, the growth of bafillus natto is had no significant effect, in C0And 2C0Dosage
Under have an impact.Flavomycoin all has an impact to the growth bean sprouts of bafillus natto under Three doses.But compared with the control group, grace
Draw the survival rate of mycin and flavomycoin group also all 60% or more.Show that enramycin and flavomycoin grow bafillus natto
Influence have dose dependent, its dosage need to be considered in practical compatibility, can accordingly reduce antibiotic dosage, increase natto
Bacillus dosage, to improve its tolerance.
(3) bafillus natto is very quick to olaquindox, the big fertilizer of speed, Bacitracin Zinc, these four antibiotic of colistin sulfate
Sense, survival rate is 20% hereinafter, be unable to compatible use.
3, it is obtained by lot of experiments, usage amount standard of the antibiotic in feed is as shown in table 1
Table 1
2 feed addictive of embodiment
1, a kind of feed addictive, containing bafillus natto and aureomycin, and bafillus natto volume (μ L) and aureomycin
The ratio of quality (mg) is 20:12.5.
2, according to 1% additive amount, above-mentioned feed addictive is added in basal diet, carry out feeding experiment, experimental period
3 months.Additive-free basal diet control group is set.
3, the results show that the piglet of experimental group be respectively increased 62.51% than the survival rate of control group, Average weight increasing a day,
23.41%。
3 feed addictive of embodiment
A kind of feed addictive, containing bafillus natto and enramycin, and bafillus natto volume (μ L) and grace drawing are mould
The ratio of quality amount (mg) is 20:12.5.
4 feed addictive of embodiment
A kind of feed addictive, containing bafillus natto and flavomycoin, and bafillus natto volume (μ L) and flavomycoin matter
The ratio for measuring (mg) is 20:50.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (8)
1. a kind of high-efficiency feed additive containing bafillus natto, which is characterized in that contain bafillus natto and antibiosis
Element, the antibiotic are aureomycin, enramycin and/or flavomycoin.
2. feed addictive according to claim 1, which is characterized in that when antibiotic is aureomycin, natto gemma bar
The amount ratio of bacterium and aureomycin is 20 μ L:10~15 mg.
3. feed addictive according to claim 1, which is characterized in that when antibiotic is aureomycin, natto gemma bar
The amount ratio of bacterium and aureomycin is 20 μ L:12.5 mg.
4. feed addictive according to claim 1, which is characterized in that when antibiotic is enramycin, natto gemma
The amount ratio of bacillus and enramycin is 20 μ L:10~15 mg.
5. feed addictive according to claim 1, which is characterized in that when antibiotic is enramycin, natto gemma
The amount ratio of bacillus and enramycin is 20 μ L:12.5 mg.
6. feed addictive according to claim 1, which is characterized in that when antibiotic is flavomycoin, natto gemma bar
The amount ratio of bacterium and flavomycoin is 20 μ L:40~60mg.
7. feed addictive according to claim 1, which is characterized in that when antibiotic is flavomycoin, natto gemma bar
The amount ratio of bacterium and flavomycoin is 20 μ L:50 mg.
8. any feed addictive according to claim 1~7, which is characterized in that the bafillus natto is bacterium solution, living
Bacterium number is 1 × 106Cfu/ul~2 × 107cfu/μL。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811150140.1A CN109170163A (en) | 2018-09-29 | 2018-09-29 | A kind of high-efficiency feed additive containing bafillus natto |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811150140.1A CN109170163A (en) | 2018-09-29 | 2018-09-29 | A kind of high-efficiency feed additive containing bafillus natto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109170163A true CN109170163A (en) | 2019-01-11 |
Family
ID=64907090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811150140.1A Pending CN109170163A (en) | 2018-09-29 | 2018-09-29 | A kind of high-efficiency feed additive containing bafillus natto |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109170163A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113462615A (en) * | 2021-08-18 | 2021-10-01 | 福建省固体废物处置有限公司 | Biodegradable composite microbial inoculum of aureomycin bacterial residue waste and compost high-temperature pre-fermentation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120276201A1 (en) * | 2009-12-31 | 2012-11-01 | Ira Milton Trachtman | Compositions and method for treatment and prophylaxis of inflammatory bowel disease |
| CN103039716A (en) * | 2013-01-10 | 2013-04-17 | 北京大北农科技集团股份有限公司 | Feed additive, premix and batch |
-
2018
- 2018-09-29 CN CN201811150140.1A patent/CN109170163A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120276201A1 (en) * | 2009-12-31 | 2012-11-01 | Ira Milton Trachtman | Compositions and method for treatment and prophylaxis of inflammatory bowel disease |
| CN103039716A (en) * | 2013-01-10 | 2013-04-17 | 北京大北农科技集团股份有限公司 | Feed additive, premix and batch |
Non-Patent Citations (5)
| Title |
|---|
| 农业农村部: "中华人民共和国农业农村部公告 第194号", 《WWW.XMSYJ.MOA.GOV.CN/ZCJD/201907/T20190710_6320678.HTM》 * |
| 曹国文等: "11株益生菌对32种抗菌药物的敏感性试验", 《饲料工业》 * |
| 杨晓斌 等: "益生菌纳豆芽孢杆菌的筛选", 《广州食品工业科技》 * |
| 王二柱等: "复合益生菌与金霉素配伍抑制金黄色葡萄球菌生长的研究", 《饲料工业》 * |
| 谢淑娥等: "芽孢杆菌的作用机理及其在饲料中的应用研究进展", 《湖南饲料》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113462615A (en) * | 2021-08-18 | 2021-10-01 | 福建省固体废物处置有限公司 | Biodegradable composite microbial inoculum of aureomycin bacterial residue waste and compost high-temperature pre-fermentation method thereof |
| CN113462615B (en) * | 2021-08-18 | 2023-05-09 | 福建省固体废物处置有限公司 | Biodegradable composite microbial agent for aureomycin residue waste and high-temperature pre-fermentation method for compost of same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jin et al. | Growth performance, intestinal microbial populations, and serum cholesterol of broilers fed diets containing Lactobacillus cultures | |
| Abdel-Raheem et al. | The effects of prebiotic, probiotic and synbiotic supplementation on intestinal microbial ecology and histomorphology of broiler chickens | |
| CN103981118B (en) | A kind of bacillus subtilis feed addictive and its preparation method and application | |
| AU2013322644B2 (en) | Probiotic and prebiotic compositions | |
| CN101971921B (en) | Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof | |
| CN102293340B (en) | Compound premix able to improve immune function for pigs | |
| CN104855684B (en) | A kind of antibacterial Chinese medicine microbial fermentation preparation and its preparation method and application | |
| CN103005159A (en) | Preparation method of ginkgo leaf biological feed additive | |
| CN103283975A (en) | A method of using spray drying for preparing probiotics micro-capsules | |
| CN103766604B (en) | A kind of preparation of composite probiotics preparations | |
| Wang et al. | Assessment of probiotic properties of Lactobacillus plantarum ZLP001 isolated from gastrointestinal tract of weaning pigs | |
| WO2009128930A1 (en) | Effects of probiotics on humans and animals under environmental or biological changes | |
| CN105567669A (en) | Probiotics microcapsule preparation and preparation method thereof | |
| CN102292430A (en) | Monogastric animal feed | |
| CN102283328A (en) | Multifunctional compound micro-ecological preparation for culturing holothurian | |
| CN102165995B (en) | Composite premix for pig | |
| CN106906166A (en) | One boar source Lactobacillus salivarius active bacteria formulation and application | |
| CN110295126B (en) | Mixed probiotic preparation and preparation process thereof | |
| CN101951922A (en) | Preparation for treating intestinal infection comprising oligosaccharides and insoluble cellular material | |
| CN105285399A (en) | Liquid state composite microecological preparation for pigling and preparation method thereof | |
| CN109170163A (en) | A kind of high-efficiency feed additive containing bafillus natto | |
| CN103211085A (en) | Efficient feed compound probiotics preparation and preparation method thereof | |
| CN109337838A (en) | A kind of aquatic products lactobacillus preparation and preparation method thereof | |
| CN107699527A (en) | A kind of probiotics micro-ecological formulation and its preparation method and application | |
| CN105831465A (en) | Application of lactobacillus plantarum strain in reduction on antibiotic residue in large-scale broiler chicken breeding |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190111 |