CN109157744B - Ultrasonic transducer support for accurate positioning of small animal through transcranial magnetic acoustic stimulation - Google Patents
Ultrasonic transducer support for accurate positioning of small animal through transcranial magnetic acoustic stimulation Download PDFInfo
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- CN109157744B CN109157744B CN201811050561.7A CN201811050561A CN109157744B CN 109157744 B CN109157744 B CN 109157744B CN 201811050561 A CN201811050561 A CN 201811050561A CN 109157744 B CN109157744 B CN 109157744B
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- 230000000638 stimulation Effects 0.000 title claims abstract description 37
- 241001465754 Metazoa Species 0.000 title claims abstract description 21
- 238000003780 insertion Methods 0.000 claims description 23
- 230000037431 insertion Effects 0.000 claims description 23
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 238000009434 installation Methods 0.000 claims description 2
- 230000033228 biological regulation Effects 0.000 abstract description 10
- 210000005036 nerve Anatomy 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 2
- 230000005284 excitation Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 230000005355 Hall effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/12—Magnetotherapy using variable magnetic fields obtained by mechanical movement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/0026—Stimulation of nerve tissue
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The ultrasonic transducer support comprises a fixed base, wherein a Z shaft supporting assembly capable of being longitudinally adjusted is vertically arranged on the fixed base, the upper end of a Z shaft supporting arm is connected with one end of an X shaft supporting arm which is horizontally arranged and can be horizontally adjusted through a first cross fastener, and the other end of the X shaft supporting arm is connected with a transducer fixing assembly for fixing an ultrasonic transducer through a second cross fastener. The ultrasonic transducer bracket for accurately positioning the transcranial magnetic acoustic stimulation of the small animal can realize accurate focusing regulation and control of the transcranial magnetic acoustic stimulation through the movement and rotation of the transducer bracket, can realize accurate regulation and control of the intensity and range of a focusing area at a stimulation target point, and is simple to operate and convenient to use. Can be used for high-focusing nerve regulation of accurate positioning, and provides a feasible method for accurate positioning stimulation of transcranial magnetoacoustic stimulation.
Description
Technical Field
The invention relates to an ultrasonic transducer support. In particular to an ultrasonic transducer bracket for accurately positioning the magnetic-acoustic stimulation of the transcranial of a small animal.
Background
Transcranial ultrasonic stimulation is a novel nerve regulation and control technology, and has attracted more and more attention due to the characteristics of non-invasiveness, high spatial resolution, realization of deep stimulation and the like. Transcranial magnetoacoustic stimulation is the result of the combined action of ultrasonic and magnetic fields applied perpendicularly to the tissue being stimulated, and is the hall effect that occurs in tissue with some electrical conductivity. The principle is that charged particles in stimulated tissues vibrate under the action of ultrasonic waves, and then cut magnetic lines of force to generate an induction electric field, so that nerve electrical activity is directly regulated and controlled. The transcranial magnetic acoustic stimulation combines ultrasonic stimulation and electrical stimulation, can generate electrical stimulation with high ultrasonic focusing performance, and has unique advantages in the aspect of nerve regulation.
The transcranial magnetic sound stimulation has unique advantages due to the focusing property, and the positioning accuracy of the generated focused ultrasound stimulation target point is the guarantee of the transcranial magnetic sound stimulation effect.
Disclosure of Invention
The invention aims to solve the technical problem of providing an ultrasonic transducer bracket which can realize the accurate regulation and control of the intensity and the range of a focusing area at a stimulation target point and is used for the accurate positioning of the transcranial magnetic acoustic stimulation of a small animal.
The technical scheme adopted by the invention is as follows: the ultrasonic transducer support comprises a fixed base, wherein a Z shaft supporting assembly capable of being longitudinally adjusted is vertically arranged on the fixed base, the upper end of a Z shaft supporting arm is connected with one end of an X shaft supporting arm which is horizontally arranged and can be horizontally adjusted through a first cross fastener, and the other end of the X shaft supporting arm is connected with a transducer fixing assembly for fixing an ultrasonic transducer through a second cross fastener.
The Z axle support subassembly include: the bottom mounting is adjusted on unable adjustment base, the Z axle support arm that can reciprocate has been inserted to the upper end of adjusting the collet, the Z axle support arm on be provided with the scale that is used for height-adjusting, threaded connection has adjusted the high back of settlement at Z axle support arm on the lateral wall of regulation collet, supports the arm to carry out the first fixed screw of fixing to Z axle, the one end of X axle support arm is connected through first cross fastener in the upper end of Z axle support arm.
The first cross fastener comprises a first columnar body, wherein a transverse insertion hole for penetrating one end of an X-axis support arm and a longitudinal insertion hole for penetrating the upper end of a Z-axis support arm in a Z-axis support assembly are formed in the first columnar body respectively, a second fixing screw which is arranged corresponding to the transverse insertion hole and is used for fixing the first columnar body and the X-axis support arm mutually and a third fixing screw which is arranged corresponding to the longitudinal insertion hole and is used for fixing the first columnar body and the upper end of the Z-axis support arm and adjusting the rotation angle of the first columnar body are formed in the first columnar body.
And scales for transverse adjustment are arranged on the X-axis supporting arm.
The second cross fastener including the second cylinder main part, the level forms be used for in the second cylinder main part running through the horizontal through-hole of X axle support arm, with the horizontal through-hole corresponding set up be used for make the second cylinder main part with X axle support arm reciprocal anchorage's fourth fixed screw, be close to in the second cylinder main part one side of horizontal through-hole vertically is formed with and is used for the installation transducer fixed component patchhole of transducer fixed component, with the corresponding fifth fixed screw that sets up in transducer fixed component patchhole be used for make the second cylinder main part with transducer fixed component reciprocal anchorage.
The transducer fixing component comprises a transducer fixing sleeve for mounting an ultrasonic transducer, a transducer clamp for clamping the transducer fixing sleeve, a transducer clamp mounting column which is integrally formed at the top end of the transducer clamp and is used for being inserted into a transducer fixing component insertion hole of a second cross fastener, and a fixing nut which is used for connecting the upper port of the transducer fixing component insertion hole and the top end of the transducer clamp mounting column in a threaded manner, wherein the transducer clamp mounting column is further fixed with the second columnar main body through a fifth fixing screw in the second cross fastener.
The ultrasonic transducer bracket for accurately positioning the transcranial magnetic acoustic stimulation of the small animal can realize accurate focusing regulation and control of the transcranial magnetic acoustic stimulation through the movement and rotation of the transducer bracket, can realize accurate regulation and control of the intensity and range of a focusing area at a stimulation target point, and is simple to operate and convenient to use. Can be used for high-focusing nerve regulation of accurate positioning, and provides a feasible method for accurate positioning stimulation of transcranial magnetoacoustic stimulation.
Drawings
FIG. 1 is a schematic diagram of the overall structure of an ultrasonic transducer support for accurate positioning of small animal transcranial magnetic acoustic stimulation according to the present invention;
FIG. 2 is a schematic perspective view of FIG. 1 after being rotated by a certain angle;
FIG. 3 is a schematic view of the construction of the Z-axis support assembly of the present invention;
FIG. 4 is a schematic view of a first fastening cross of the present invention;
FIG. 5 is a schematic view of a second fastening cross of the present invention;
FIG. 6 is a schematic view of the transducer mounting assembly of the present invention assembled with a second cross fastener;
FIG. 7 is a schematic diagram of the construction of the transducer mounting sleeve of the present invention;
fig. 8 is a schematic diagram of the application state of the ultrasonic transducer support for accurate positioning of small animal transcranial magnetic acoustic stimulation.
In the drawings
1: the fixed base 2: z axle support assembly
2.1: adjust collet 2.2: z-axis support arm
2.3: first fixing screw 3: first cross fastener
3.1: first columnar body 3.2: transverse insertion hole
3.3: longitudinal insertion hole 3.4: third fixing screw
3.5: second fixing screw 4: x-ray shaft support arm
5: second fastening cross 5.1: second column main body
5.2: horizontal through hole 5.3: fourth fixing screw
5.4: transducer fixing assembly insertion hole 5.5: fifth set screw
6: transducer fixing assembly 6.1: transducer fixing sleeve
6.2: transducer clamp 6.3: transducer clamp mounting post
6.4: fixing nut 6.5: spacing boss
11: the ultrasonic excitation module 12: ultrasonic transduction module
13: test small animal 14: brain stereotaxic instrument
15: ultrasound transducer holder 16: magnetostatic iron
17: mobile rotating device
Detailed Description
The invention provides an ultrasonic transducer bracket for accurate positioning of small animal transcranial magnetic acoustic stimulation, which is described in detail with reference to the embodiments and the attached drawings.
As shown in fig. 1 and 2, the ultrasonic transducer support for accurate positioning of transcranial magnetic acoustic stimulation of a small animal of the present invention comprises a fixing base 1, a Z-axis support assembly 2 capable of being adjusted longitudinally is vertically arranged on the fixing base 1, the upper end of the Z-axis support arm 2 is connected with one end of an X-axis support arm 4 which is horizontally arranged and capable of being adjusted horizontally through a first cross fastener 3, the other end of the X-axis support arm 4 is connected with a transducer fixing assembly 6 for fixing an ultrasonic transducer through a second cross fastener 5, and scales for performing horizontal adjustment are arranged on the X-axis support arm 4.
As shown in fig. 3, the Z-axis support assembly 2 includes: the bottom mounting is adjusted collet 2.1 on unable adjustment base 1, the upper end of adjusting collet 2.1 is inserted and is had the Z axle that can reciprocate to support arm 2.2, Z axle support arm 2.2 on be provided with the scale that is used for height-adjusting, threaded connection has the high back of settlement at Z axle support arm 2.2 on the lateral wall of adjusting collet 2.1, supports arm 2.2 to carry out the first set screw 2.3 of fixing to Z axle, the one end of X axle support arm 4 is connected through first cross fastener 3 in the upper end of Z axle support arm 2.2.
As shown in fig. 4, the first cross fastener 3 includes a first cylindrical body 3.1, the first cylindrical body 3.1 is formed with a transverse insertion hole 3.2 for penetrating one end of the X-axis support arm 4 and a longitudinal insertion hole 3.3 for penetrating the upper end of the Z-axis support arm 2.2 in the Z-axis support assembly 2, a second fixing screw 3.5 corresponding to the transverse insertion hole 3.2 for fixing the first cylindrical body 3.1 and the X-axis support arm 4 to each other, and a third fixing screw 3.4 corresponding to the longitudinal insertion hole 3.3 for fixing the first cylindrical body 3.1 and the upper end of the Z-axis support arm 2.2 and adjusting the rotation angle of the first cylindrical body 3.1.
As shown in fig. 5, the second fastening cross 5 includes a second cylindrical body 5.1, a horizontal through hole 5.2 horizontally formed on the second cylindrical body 5.1 for passing through the X-axis support arm 4, a fourth fixing screw 5.3 disposed corresponding to the horizontal through hole 5.2 for fixing the second cylindrical body 5.1 and the X-axis support arm 4 to each other, a transducer fixing member insertion hole 5.4 longitudinally formed on the second cylindrical body 5.1 at a side adjacent to the horizontal through hole 5.2 for mounting the transducer fixing member 6, and a fifth fixing screw 5.5 disposed corresponding to the transducer fixing member insertion hole 5.4 for fixing the second cylindrical body 5.1 and the transducer fixing member 6 to each other.
As shown in fig. 6 and 7, the transducer fixing assembly 6 includes a transducer fixing sleeve 6.1 for mounting an ultrasonic transducer, a transducer clamp 6.2 for clamping the transducer fixing sleeve 6.1, a transducer clamp mounting post 6.3 integrally formed at the top end of the transducer clamp 6.2 for inserting into a transducer fixing assembly insertion hole 5.4 of the second cross fastener 5, and a fixing nut 6.4 for screwing with the top end of the transducer clamp mounting post 6.3 at the upper port of the transducer fixing assembly insertion hole 5.4, wherein the transducer clamp mounting post 6.3 is further fixed with the second cylindrical body 5.1 by a fifth fixing screw 5.5 in the second cross fastener 5. A circle of limiting bosses 6.5 playing a limiting role are formed on the outer side of the transducer fixing sleeve 6.1, and the vertical angle of the ultrasonic transducer can be adjusted by rotating the transducer fixing sleeve 6.1 in the transducer clamp 6.2.
The ultrasonic transducer bracket for the transcranial magnetic acoustic stimulation precise positioning of the small animal can enable an ultrasonic transducer to translate in the X direction and move up and down in the Z direction, and the precision is 1 mm; the horizontal rotation is 0-90 degrees, the vertical rotation is 0-90 degrees, and therefore accurate stimulation to the small animals can be achieved.
Fig. 8 is an application example of an ultrasonic transducer support for accurate positioning of small animal transcranial magnetic acoustic stimulation according to the invention. As shown in the figure, a small animal 13 to be tested is fixed on a heating pad of a brain stereotaxic apparatus 14. An ultrasonic excitation module 11 consisting of two function signal generators and a power amplifier which are connected in sequence generates a specific ultrasonic excitation signal, an ultrasonic transduction module 12 consisting of an ultrasonic transducer and an acoustic collimator connected to the bottom end of the ultrasonic transducer is supported on an ultrasonic transducer bracket 15 for accurate positioning of magnetic acoustic stimulation of the transcranial of the small animal, converts an ultrasonic excitation electric signal into an acoustic signal and vertically targets the acoustic signal to a stimulation area of a tested small animal 13; the moving and rotating device 17 loaded with the static magnet 16 drives the static magnet 16 to move to the front side of the tested small animal 13, and enables the static magnet 16 to move to be placed right in front of the tested small animal 13, thereby realizing transcranial magnetoacoustic coupling electric stimulation.
When the ultrasonic transducer needs to horizontally rotate by 0-90 degrees, the rotation angle between the first cross fastener 3 and the X-ray shaft support arm 4 is adjusted through a third fixing screw 3.4; when the ultrasonic transducer needs to vertically rotate by 0-90 degrees, the rotating angle between the second cross fastener 5 and the transducer fixing component 6 is adjusted through the fifth fixing screw 5.5. Or the vertical angle of the ultrasonic transducer can be adjusted by rotating the transducer fixing sleeve 6.1. When the height of the ultrasonic transducer needs to be adjusted, the depth of the X-axis supporting arm 4 inserted into the adjusting bottom support 2.1 is adjusted through the first fixing screw 2.3; when the transverse position of the ultrasonic transducer person needs to be adjusted, the left and right positions of the X-axis support arm 4 of the first cross fastener 3 or the second cross fastener 5 are adjusted through the second fixing screw 3.5 or the fourth fixing screw 5.3.
Claims (2)
1. An ultrasonic transducer support for accurate positioning of transcranial magnetic acoustic stimulation of small animals comprises a fixed base (1) and is characterized in that a Z-axis support assembly (2) capable of being adjusted longitudinally is vertically arranged on the fixed base (1), the upper end of the Z-axis support arm (2) is connected with one end of an X-axis support arm (4) which is horizontally arranged and can be adjusted horizontally through a first cross fastener (3), and the other end of the X-axis support arm (4) is connected with a transducer fixing assembly (6) for fixing an ultrasonic transducer through a second cross fastener (5); wherein,
the Z-axis support assembly (2) comprises: the bottom end of the adjusting bottom support (2.1) is fixed on the fixing base (1), a Z-axis supporting arm (2.2) capable of moving up and down is inserted into the upper end of the adjusting bottom support (2.1), scales for adjusting the height are arranged on the Z-axis supporting arm (2.2), a first fixing screw (2.3) for fixing the Z-axis supporting arm (2.2) after the Z-axis supporting arm (2.2) is adjusted to the set height is in threaded connection with the side wall of the adjusting bottom support (2.1), and the upper end of the Z-axis supporting arm (2.2) is connected with one end of an X-axis supporting arm (4) through a first cross fastener (3);
the first cross fastener (3) comprises a first columnar main body (3.1), wherein a transverse insertion hole (3.2) for penetrating one end of the X-axis supporting arm (4) and a longitudinal insertion hole (3.3) for penetrating the upper end of the Z-axis supporting arm (2.2) in the Z-axis supporting assembly (2) are respectively formed in the first columnar main body (3.1), a second fixing screw (3.5) which is arranged corresponding to the transverse insertion hole (3.2) and is used for fixing the first columnar main body (3.1) and the X-axis supporting arm (4) mutually, and a third fixing screw (3.4) which is arranged corresponding to the longitudinal insertion hole (3.3) and is used for fixing the first columnar main body (3.1) and the upper end of the Z-axis supporting arm (2.2) and adjusting the rotation angle of the first columnar main body (3.1);
the transducer fixing assembly (6) comprises a transducer fixing sleeve (6.1) for mounting an ultrasonic transducer, a transducer clamp (6.2) for clamping the transducer fixing sleeve (6.1), a transducer clamp mounting column (6.3) which is integrally formed at the top end of the transducer clamp (6.2) and is used for being inserted into a transducer fixing assembly insertion hole (5.4) of a second cross fastener (5), and a fixing nut (6.4) which is used for being in threaded connection with the top end of the transducer clamp mounting column (6.3) at the upper port of the transducer fixing assembly insertion hole (5.4), wherein the transducer clamp mounting column (6.3) is further fixed with a second columnar body (5.1) through a fifth fixing screw (5.5) in the second cross fastener (5);
second cross fastener (5) including second columnar body (5.1), the level forms be used for on second columnar body (5.1) running through horizontal through-hole (5.2) of X axle support arm (4), with horizontal through-hole (5.2) correspond set up be used for make second columnar body (5.1) with X axle support arm (4) fourth fixed screw (5.3) of mutual fixation, be close to on second columnar body (5.1) one side of horizontal through-hole (5.2) is vertically formed with and is used for the installation transducer fixed subassembly patchhole (5.4) of transducer fixed subassembly (6), with transducer fixed subassembly patchhole (5.4) correspond set up be used for make second columnar body (5.1) with transducer fixed subassembly (6) reciprocal anchorage's fifth fixed screw (5.5).
2. The ultrasonic transducer support for the accurate positioning of the transcranial magnetoacoustic stimulation of the small animals according to claim 1, wherein scales for transverse adjustment are provided on the X-axis supporting arm (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811050561.7A CN109157744B (en) | 2018-09-07 | 2018-09-07 | Ultrasonic transducer support for accurate positioning of small animal through transcranial magnetic acoustic stimulation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811050561.7A CN109157744B (en) | 2018-09-07 | 2018-09-07 | Ultrasonic transducer support for accurate positioning of small animal through transcranial magnetic acoustic stimulation |
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| CN109157744A CN109157744A (en) | 2019-01-08 |
| CN109157744B true CN109157744B (en) | 2022-05-20 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559564B (en) * | 2019-09-02 | 2021-08-20 | 深圳先进技术研究院 | Ultrasonic stimulation device, terminal and medium |
| CN110639134A (en) * | 2019-09-30 | 2020-01-03 | 秦皇岛市第一医院 | Ultrasonic probe adjusting device, ultrasonic probe adjusting method and transcranial nerve stimulator |
| CN113101524A (en) * | 2021-04-12 | 2021-07-13 | 中国医学科学院生物医学工程研究所 | Transcranial magnetoacoustic stimulation device capable of flexibly realizing vector stimulation of whole brain area |
| CN113350707B (en) * | 2021-05-31 | 2022-09-20 | 中南大学湘雅二医院 | Device for ultrasonically stimulating nerve tissues |
| CN113559425B (en) * | 2021-07-29 | 2023-07-21 | 陕西师范大学 | Focusing ultrasonic regulation and control device and method for small animal brain functional area positioning stimulation |
| CN113729716B (en) * | 2021-09-30 | 2024-06-21 | 中国医学科学院生物医学工程研究所 | Magnetic sound imaging device for brain of small animal |
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| GB857272A (en) * | 1958-08-29 | 1960-12-29 | Emi Ltd | Improvements in or relating to means for mounting magnetic transducing heads |
| JP6363229B2 (en) * | 2014-02-05 | 2018-07-25 | ベラソン インコーポレイテッドＶｅｒａｔｈｏｎ Ｉｎｃ． | Ultrasonic data collection |
| JP6571461B2 (en) * | 2015-09-09 | 2019-09-04 | キヤノンメディカルシステムズ株式会社 | Ultrasonic diagnostic apparatus, medical image processing apparatus, and medical image processing program |
| CN111888671B (en) * | 2020-08-06 | 2021-05-04 | 上海交通大学 | Ultrasonic transducer coupling device for human transcranial ultrasonic stimulation |
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| CN104248448A (en) * | 2013-06-25 | 2014-12-31 | 深圳市开立科技有限公司 | Ultrasonic three-dimensional imaging probe |
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