CN109115552B

CN109115552B - Sampling clamp

Info

Publication number: CN109115552B
Application number: CN201810963599.7A
Authority: CN
Inventors: 魏国平; 韦松
Original assignee: Shenyang Original Pharmacy Co ltd
Current assignee: Shenyang Original Pharmacy Co ltd
Priority date: 2018-08-23
Filing date: 2018-08-23
Publication date: 2024-01-23
Anticipated expiration: 2038-08-23
Also published as: CN109115552A

Abstract

The sampling clamp belongs to medicine dissolving equipment technical field, especially relates to a sampling clamp. The invention provides a sampling clamp which is convenient for dismounting a sampling assembly and sampling of the sampling assembly. The invention comprises a drawing component for driving the sampling component to sample, a fixed clamping part and a movable clamping part which are transversely arranged.

Description

Sampling clamp

Technical Field

The invention belongs to the technical field of medicine dissolving equipment, and particularly relates to a sampling clamp.

Background

Drug dissolution refers to the rate and extent of dissolution of active pharmaceutical ingredients from a formulation such as a tablet, capsule or granule under prescribed conditions. It is an important index for evaluating the quality of oral solid preparation. The automation degree of the existing dissolution instrument needs to be improved. An automatic dissolution apparatus is manufactured by providing a suitable sampling clamp.

Disclosure of Invention

The present invention is directed to the above-mentioned problems, and provides a sampling clamp which is convenient for assembling and disassembling a sampling assembly and sampling the sampling assembly.

In order to achieve the purpose, the invention adopts the following technical scheme that the sampling device comprises a drawing component for driving a sampling assembly to sample, a fixed clamping part and a movable clamping part which are transversely arranged.

As another preferable scheme, the invention further comprises a bearing beam, wherein the fixed clamping part and the movable clamping part are a plurality of groups of fixed clamping parts and movable clamping parts which are uniformly arranged on the bearing beam along the length direction of the bearing beam, the matching part of the sampling assembly and the clamping surface is a cylinder, and the clamping surface is provided with curved surface grooves corresponding to the outer wall of the cylinder.

As another preferable scheme, the sampling assembly adopts a needle tube type piston extraction structure; the drawing component comprises a lifting beam, a clamping groove is formed in the lifting beam corresponding to the upper end of the piston, and the lifting beam is connected with the bearing beam through a lifting mechanism.

As another preferable scheme, a filter tip is arranged at the lower end extraction opening of the sampling assembly.

Secondly, the lifting mechanism comprises a transverse pulling syringe motor arranged on a sliding seat of the sampling manipulator, an output shaft of the pulling syringe motor is connected with a pulling syringe gear, the pulling syringe gear is meshed with a vertical rack, and an upward pulling transverse plate is arranged at the lower end of the vertical rack corresponding to the lifting cross beam.

In addition, the two sides of the lifting beam are provided with the guide posts which extend downwards, the bearing beam is provided with the guide sleeves corresponding to the guide posts, and the guide posts penetrate through the guide sleeves.

The invention has the beneficial effects that.

The invention is provided with the drawing component, the fixed clamping part, the movable clamping part and the elastic reset mechanism, thereby being convenient for the disassembly and assembly of the sampling assembly and the sampling of the sampling assembly.

Drawings

The invention is further described below with reference to the drawings and the detailed description. The scope of the present invention is not limited to the following description.

FIG. 1 is a schematic view of the structure of the automatic digestion instrument of the present invention.

Fig. 2 is a rear view of the automatic digestion unit of the present invention.

FIG. 3 is a side view of the automatic digestion instrument of the present invention.

FIG. 4 is a top view of the automatic digestion instrument of the present invention.

FIG. 5 is a schematic view of the structure of the propeller shaft assembly of the present invention.

FIG. 6 is a top view of the shaft assembly of the present invention.

FIG. 7 is a schematic view of the basket shaft transport lift and rotate assembly of the present invention.

FIG. 8 is a schematic view of the structure of the sampling clip and sampling assembly of the present invention.

Fig. 9 is a schematic view of the frame structure of the present invention.

FIG. 10 is a schematic view of a synchronous link plate structure of the present invention.

Fig. 11 is a top view of the synchronization link of the present invention.

Fig. 12 is a side view of a synchronization link of the present invention.

Fig. 13 is a side view of a cartridge of the present invention.

Fig. 14 is a schematic view of the structure of the drug storage box of the present invention.

Fig. 15 is a schematic view of the structure of the dissolution cup and the water tank of the present invention.

Fig. 16 is a top view of the dissolution cup and water tank of the present invention.

Fig. 17 is a left side view of the sampling robot of the present invention.

Fig. 18 is a front view of the sampling robot of the present invention.

Fig. 19 is a right side view of the sampling robot of the present invention.

FIG. 20 is a schematic diagram of the pH meter drive calibration assembly of the present invention.

FIG. 21 is a side view of a pH meter drive calibration assembly of the present invention.

Fig. 22 is an enlarged view of a portion a of fig. 7.

Fig. 23 is an enlarged view of a portion B of fig. 7.

Fig. 24 is an enlarged view of a portion C of fig. 8.

Fig. 25 is an enlarged view of a portion D of fig. 9.

Fig. 26 is an enlarged view of the portion E of fig. 14.

FIG. 27 is a schematic block diagram of an automatic digestion unit of the present invention.

FIG. 28 is an electrographic representation of an automatic dissolution apparatus of the present invention.

Fig. 29 and 30 are partial enlarged views of fig. 28.

Fig. 31 is a top view of the frame of the present invention.

Fig. 32 is an enlarged view of the portion F in fig. 5.

Fig. 33 is an enlarged view of a portion G of fig. 5.

FIG. 34 is a schematic view of the falling-off collection assembly of the medicine basket of the present invention.

FIG. 35 is a top view of the basket drop-out collection assembly of the present invention.

FIG. 36 is a side view of a shaft assembly of the present invention.

Fig. 37 is a schematic view of the driven pulley transmission structure of the present invention.

Fig. 38 is a diagram showing the configuration of the cooperation of the medicine storing slide block, the medicine storing guide rail and the driving rack according to the present invention.

FIG. 39 is a schematic view of the claw portion of the sampling robot of the present invention.

Fig. 40 is a view showing a structure of a lifting drive of a lifting beam according to the present invention.

In the drawing the view of the figure, the device comprises a slide seat 1, a frame 2, a sampling manipulator 3, a sampling clamp 4, a sampling assembly 5, a sampling carriage 6, a lofting carriage 7, a medicine basket falling and collecting assembly 8, a medicine storage box 9, a medicine storage box 10, a support Ma Lun, a support column 11, a basket shaft conveying lifting and rotating assembly 12, a water tank 13, a paddle shaft assembly 14, a pH meter driving and calibrating assembly 15, a lifting rail 16, a medicine basket conveying frame 17, a U-shaped medicine basket falling opening 18, a movable bottom plate front pulling baffle 19, a medicine storage box 20, a medicine basket bearing groove 21, a medicine storage rotary disc 22, a lifting beam 23, a lifting beam 24, a bearing bottle body 25, a lifting shaft gear 26, a motor 27, a rotary rod 28, a rotary rod clamp sleeve 29, a driven pulley 30, a suction pipe 32, a pH adjusting pipe 33, a dissolving cup cover 34, a motor 35, a bearing 36, a water injection pipe and a box 37 is a supporting bearing, 38 is a lifting shaft gear, 39 is a driving belt pulley, 40 is a motor, 41 is a rotating rod clamping sleeve, 42 is a bearing, 43 is a driven belt pulley, 44 is a supporting bearing, 45 is a rotating rod, 46 is a motor, 47 is a bearing, 48 is a lifting shaft gear, 49 is a motor gear, 50 is a jackscrew, 51 is a clamping sleeve gasket, 52 is a belt, 53 is a cross rod, 54 is a guide sleeve, 55 is a guide pillar, 56 is an elastic reset mechanism, 57 is a movable clamping part, 58 is a fixed clamping part, 59 is a bearing cross beam, 60 is a screw rod, 61 is a slide rail, 62 is a cleaning cup upper part, 63 is a cleaning cup middle part, 64 is a cleaning cup lower part (a water delivery channel can be arranged in the cleaning cup wall), 65 is a cleaning tube, 66 is a rack for driving a medicine taking clamp to lift, 67 is a rack for driving a stirring head to lift, 68 is a front-back translation slide rail of a pH meter conveying frame, 69 is a bearing cross plate, A motor 70, a synchronous connecting plate 71, a driven pulley tensioning block 72, a driven pulley 73, a medicine storage guide rail 74, a belt 75, a driving pulley 76, a driving plate 77, a vacancy 78, a digital mark 79, a propeller shaft conveying frame 80, a basket shaft conveying frame 81, a medicine storage rotary table motor 82, a medicine storage slide 83 (the medicine storage slide 83 is arranged on the medicine storage guide rail 74, the medicine storage slide 83 is fixed with a transmission rack 84, the transmission rack 84 is ensured to horizontally run), the transmission rack 84 is a driven gear 85, the medicine box cover 86, the rotating shaft 87, the medicine basket 88, the cleaning cup 89, the dissolution cup 90, the lifting shaft gear 91, the syringe pulling motor 92, the syringe pulling gear 93, the rack 94, the upper spring washer 95 is used for clamping a pressure spring 102, the upper spring washer 95 is sleeved on the 133), the front and rear guide rod sliding frame 96 is a lifting motor 97, the upper belt pulley 98 is a lifting belt 99, the lower belt 100 is a triangular plate 101, the pressure spring 103 is a pressure spring 103, the lower motor 103 is a pressure spring 104, the lower guide rod 104 is a cam 104 and the upper cam 104 is a groove which is matched with the two ends of the upper end of the upper cam and is a middle part of the upper cam is provided with a vertical through hole; the lower end of the grabbing pressure spring 102 is propped against the claw main body, the upper end is propped against the lower end of the upper spring washer 95 on the guide rod, the guide rod on the upper end of the upper spring washer 95 is provided with a limit nut, the claw movement motor 103 rotates to drive the claw cam 104 to rotate, the lower claw 106 is contacted with the claw cam 104 at any moment under the action of the grabbing pressure spring 102, the claw is opened and closed), 107 is a motor, 108 is a gear, 109 is a driven pulley, 110 is a slide rail, 111 is a motor gear, 112 is a pH value detection head, 113 is a pH value detection head bearing sleeve, 114 is a gear, 115 is a rack, 116 is a slide seat, 117 is a motor, 118 is a vertical guide groove, 119 is a lifting beam, 120 is a sampling port, 121 is a pH value adjustment sampling port, 122 is a belt, 123 is a clamping groove, 124 is a filter tip, 125 is a material frame drawer bottom plate, 126 is a side longitudinal section bar, 127 is a rear transverse section bar, 128 is a countersunk screw, 129 is a built-in nut, 130 is a section bar angle joint piece, 131 is an inner hexagon screw, 132 is a plastic handle, 133 is a guide rod, 134 is a transmission gear, 135 is a lifting shaft, and 136 is a pull-up transverse plate.

Detailed Description

As shown in the figure, the invention can be applied to an automatic dissolution instrument, the automatic dissolution instrument comprises a frame, a sampling structure is arranged at the upper part of the frame, a medicine basket conveying mechanism, a basket shaft conveying lifting rotating assembly capable of translating back and forth on the frame, a paddle shaft assembly capable of translating back and forth on the frame and a pH meter driving calibrating assembly are sequentially arranged at the lower part of the frame from front to back, and dissolution cups are arranged on the frame below the basket shaft conveying lifting rotating assembly and the paddle shaft assembly.

The automatic dissolution instrument can improve the automation degree and the inspection efficiency through the matched use of the components.

The sampling and lofting structure comprises a sampling slide way, a lofting slide way and a sampling sliding frame arranged on the sampling slide way, wherein the lofting slide way is provided with the lofting sliding frame;

the sampling structure further comprises a sampling clamp which can be placed on the sampling carriage and the sampling carriage, a sampling assembly which can be connected with the sampling clamp in a disassembling and assembling mode, and a sampling manipulator which can take down the sampling clamp from the sampling carriage and then put the sampling assembly into the sampling port of the basket shaft conveying lifting rotating assembly and then put the sampling assembly onto the sampling carriage upwards.

Set up sample slide, lofting slide, sample balladeur train, lofting balladeur train, sample clamp and sampling manipulator, the getting of the experimental sample of being convenient for is put.

And the detachable connection structure is arranged between the sampling sliding frame and the sampling sliding rail and between the lofting sliding frame and the lofting sliding rail.

The front part and the rear part of two sides of the frame are respectively provided with a sampling slideway and a lofting slideway support, the upper ends of the supports extend to the upper end of the frame, and the lower ends of the supports extend to the upper end of the dissolution cup.

The sampling slide way is arranged above the lofting slide way.

The sampling slide way adopts a fully-opened slide way.

The sampling manipulator is arranged on a lifting mechanism on the front-back movement sliding frame, and two sides of the front-back movement sliding frame are arranged on sliding rails on the frame.

The lifting mechanism comprises a vertical lifting rail, a transverse lifting motor is arranged at the upper end of the lifting rail, an output shaft of the lifting motor is connected with an upper belt pulley, and the upper belt pulley is connected with a lower belt pulley at the lower end of the lifting rail through a lifting belt; the lifting rail is provided with a sliding seat, the sampling manipulator is arranged on the sliding seat, one side of the sliding seat is provided with a triangular plate extending backwards, and the rear end of the triangular plate is connected with the lifting belt.

The sliding frame is characterized in that a threaded hole is formed in the front-back movement sliding frame, a screw is screwed in the threaded hole, and the end of the screw is connected with a motor on the frame.

The sampling clamps are a plurality of, transversely uniformly distributed along the length direction of the lofting sliding frame, and the lofting sliding frame is provided with a sampling clamp translation driving mechanism for driving each sampling clamp to sequentially move forwards.

The sampling clamp translation driving mechanism comprises a driving belt pulley and a driven belt pulley, the driving belt pulley is connected with the driven belt pulley through a belt, the driving belt pulley and the driven belt pulley are respectively arranged at the front end and the rear end of the lofting sliding frame, the driving belt pulley is connected with a motor, and the end part of the sampling clamp is arranged on the belt.

The sampling clamp comprises a drawing part for driving the sampling assembly to sample, a fixed clamping part and a movable clamping part which are transversely arranged, wherein the opposite surface of the fixed clamping part and the movable clamping part is a clamping surface of the sampling assembly, and the movable clamping part transversely moves through an elastic reset mechanism and clamps the sampling assembly.

The sampling clamp comprises a bearing beam (the bearing beam is a clamping object of a sampling manipulator), a fixed clamping part and a movable clamping part are uniformly arranged on the bearing beam along the length direction of the bearing beam, the matching part of the sampling assembly and a clamping surface is a cylinder, and a curved surface groove corresponding to the outer wall of the cylinder is formed in the clamping surface.

The sampling assembly adopts a needle tube type piston extraction structure; the drawing component comprises a lifting beam, a clamping groove is formed in the lifting beam corresponding to the upper end of the piston, and the lifting beam is connected with the bearing beam through a lifting mechanism.

The sampling assembly adopts a needle tube type piston extraction structure, has a compact structure and is convenient for sampling. The clamping groove is formed, the upper end of the sampling assembly is connected with the lifting beam, and the lifting beam drives the piston to move upwards for sampling.

The sampling assembly lower extreme extraction mouth department is provided with the filter tip.

The lifting mechanism comprises a transverse pulling syringe motor arranged on a sliding seat of the sampling manipulator, an output shaft of the pulling syringe motor is connected with a pulling syringe gear, the pulling syringe gear is meshed with a vertical rack, and a pulling transverse plate 136 is arranged at the lower end of the vertical rack 94 corresponding to the lifting cross beam 119.

Guide posts extending downwards are arranged on two sides of the lifting beam, guide sleeves are arranged on the bearing beam corresponding to the guide posts, and the guide posts penetrate through the guide sleeves.

The medicine basket conveying mechanism comprises a medicine basket conveying frame capable of translating back and forth.

The medicine basket conveying mechanism further comprises a medicine storage box arranged at the front end of the frame, a medicine storage rotary table used for placing medicine baskets is arranged in the medicine storage box, the medicine basket conveying frame is arranged below the medicine storage box, a plurality of through holes are uniformly distributed on the medicine storage rotary table along the circumferential direction, and medicine basket falling holes are formed in the bottom plate of the medicine storage box and correspond to the medicine basket placing through holes and medicine basket bearing grooves in the medicine basket conveying frame.

After the medicine storage rotary table is arranged, a plurality of medicine baskets are conveniently placed in one time, experiments are carried out according to the sequence, and the degree of automation is improved. The medicine basket conveying frame is arranged to be convenient for conveying the medicine basket to the position of the next step of the experiment. The medicine basket placing through holes are arranged, so that the medicine basket is placed on the medicine storage rotary table conveniently. After the medicine basket falling holes are formed, the medicine storage turntable can rotate in place conveniently, and the medicine basket falls into the medicine basket bearing groove on the medicine basket conveying frame.

The medicine basket conveying frame comprises a medicine basket conveying cross beam, lower ends of two sides of the medicine basket conveying cross beam are arranged on sliding rails on the frame, a medicine basket bearing piece is arranged on the medicine basket conveying cross beam, and a medicine basket bearing groove is formed in the medicine basket bearing piece.

The medicine basket conveying beam is characterized in that driving plates extending downwards are arranged on two sides of the medicine basket conveying beam, the lower ends of the driving plates are connected with a belt, two ends of the belt are respectively wound around a driving belt wheel and a driven belt wheel which are arranged on the frame, and the driving belt wheel is connected with a motor.

The bottom plate of medicine basket loading groove is movable bottom plate, and movable bottom plate front end is the downwardly extending and dissolves preceding frame complex movable bottom plate front pull baffle on the cup, is provided with movable bottom plate reset spring on the medicine basket loading groove.

The rear end of the medicine basket bearing piece is provided with a U-shaped medicine basket clamping falling opening.

The upper end face of the U-shaped medicine basket clamp falling opening is an inclined plane which is inclined downwards from inside to outside, and the lower end face of the U-shaped medicine basket clamp falling opening is a plane.

The liquid inlet hole on the medicine basket is arranged at the lower end of the medicine basket.

The upper end of the medicine storage box is provided with a medicine box cover

The medicine box cover is made of transparent materials.

The medicine box cover is a transverse L-shaped medicine box cover, and the front lower end of the medicine box cover is connected with the front end of the medicine storage box in a shaft way.

The medicine storage turntables are multiple and are transversely and uniformly distributed, and the arrangement direction of the medicine storage turntables is perpendicular to the conveying direction of the medicine basket conveying mechanism.

The medicine storage box is characterized in that one side of the medicine storage box is provided with a vertical medicine storage rotary table motor, an output shaft of the medicine storage rotary table motor is provided with a driving gear, and the driving gear is connected with a driven gear on a medicine storage rotary table rotating shaft through a transverse transmission rack.

The medicine basket placing through holes are round holes, the medicine basket is barrel-shaped, a vacancy of the medicine basket placing through holes is reserved between the foremost medicine basket placing through holes and the rearmost medicine basket placing through holes, and the medicine basket falling holes are arranged corresponding to the rear end positions of the medicine storage rotary table.

The upper end of the medicine basket bearing groove is a bell mouth which diffuses from bottom to top.

Six medicine storage turntables are arranged, and eight medicine baskets are arranged in each medicine storage turntable.

And a digital mark corresponding to the medicine basket placing through holes is arranged on the medicine storage rotary table at the inner side of each medicine basket placing through hole.

And a medicine basket falling and collecting assembly is arranged on the frame below the medicine basket conveying mechanism.

The medicine basket falling and collecting assembly is arranged on the frame by adopting a drawer type structure. The drawer type structure is adopted to facilitate the taking and placing of the medicine basket falling and collecting assembly.

The medicine basket drops and collects the subassembly front end middle part and is provided with horizontal plastics handle, and plastics handle both ends link to each other with medicine basket and drop and collect the subassembly main part through hexagon socket head cap screw.

The medicine basket falling and collecting assembly comprises a front transverse section and a rear transverse section, wherein the front transverse section is connected with the two ends of the rear transverse section through side longitudinal sections, and the transverse section is connected with the longitudinal sections and a drawer bottom plate of a section frame through section corner connectors, countersunk head screws and built-in nuts.

And the profile frame drawer bottom plate adopts a polytetrafluoroethylene plate.

The basket shaft conveying lifting rotating assembly, the paddle shaft assembly and the pH meter driving calibrating assembly synchronously translate.

The basket shaft conveying lifting rotating assembly comprises a basket shaft conveying frame, lower ends of two sides of the basket shaft conveying frame are arranged on sliding rails on the frame, and lifting medicine taking basket clamping heads are arranged on the basket shaft conveying frame.

Through basket axle conveying frame and slide rail, the translation of getting it filled basket dop back and forth is convenient for. The liftable medicine taking basket clamping head is convenient for the clamping head to descend to grab the medicine basket and then to lift the medicine basket upwards to move to a required position.

The medicine taking basket clamp head is connected with the lifting cross beam through the rotating rod and the bearing at the upper end of the medicine taking basket clamp head, a solution sampling port in the dissolution cup is arranged on the lifting cross beam, and two ends of the lifting cross beam are connected with the basket shaft conveying frame through the motor, the gear and the rack mechanism. The two ends of the lifting cross beam are connected with the basket shaft conveying frame through a motor, a lifting shaft gear, a lifting motor gear and a rack mechanism, and a pH value adjusting sampling port is arranged on the lifting cross beam. The lifting motor gear is connected with an output shaft of the motor, the lifting motor gear is meshed with a transmission gear on the lifting shaft, the lifting shaft gear is meshed with the rack mechanism, and the rack mechanism is arranged on the basket shaft conveying frame; the motor and the lifting shaft are arranged on the lifting cross beam. The rack mechanism is fixed, and the lifting shaft gear moves up and down along the rack mechanism to drive the lifting cross beam to lift.

One end of the lifting beam is provided with a transverse driving belt pulley, the driving belt pulley is connected with a motor shaft extending downwards from a motor above the driving belt pulley, and the motor is arranged on the lifting beam; each rotating lever is provided with a driven pulley, and the driven pulley 43 is connected to the driving pulley 39 via a belt 52. Compression support bearings 44 may be disposed on both sides of the driven pulley 43, and the compression support bearings 44 compress the belt 52 against the driven pulley 43 to transmit power from the driving pulley 39 to the driven pulley 43.

The driving motor of the rotating rod at the upper end of the medicine taking basket clamping head is provided with a speed adjusting device.

The paddle shaft assembly comprises a paddle shaft conveying frame, lower ends of two sides of the paddle shaft conveying frame are arranged on sliding rails on the frame, and a liquid adding part and a liftable stirring head are arranged on the paddle shaft conveying frame.

Through oar axle conveying frame, slide rail, be convenient for the translation around liquid feeding part and the stirring head of liftable. The liftable stirring head is convenient for the stirring head to enter the dissolution cup for stirring and leave the dissolution cup. The liquid adding component is arranged to facilitate the addition of the required solution into the dissolution cup.

The paddle shaft assembly also includes a dissolution cup solution suction component.

The solution sucking component of the dissolving cup comprises a sucking pipe which is connected with a water pump.

And a control signal input port of the water pump connected with the draft tube is connected with a control signal output port of the controller.

The water pump connected with the draft tube adopts an industrial injection pump.

The draft tube is inclined from the rear upper side to the front lower side.

The paddle shaft assembly also includes a dissolution cup water injection component.

The cup water injection part comprises a water injection pipe which is connected with a water pump.

And a control signal input port of the water pump connected with the water injection pipe is connected with a control signal output port of the controller.

And the water injection pipe adopt an industrial injection pump.

The paddle axle subassembly below is provided with the water tank, dissolves out the cup setting in the water tank.

A heating component is arranged in the water tank. The water in the water tank keeps the constant temperature of the dissolving cup.

The control signal input port of the heating component is connected with the control signal output port of the controller.

The water temperature in the water tank is 37+/-0.5 ℃.

The water inlet of the water tank is connected with the water injection pump, the water outlet of the water tank is connected with the water suction pump, and the control signal input port of the water injection pump contactor for controlling the water injection pump and the control signal input port of the water suction pump contactor for controlling the water suction pump are respectively connected with the control signal output port of the PLC.

The water injection pipe is inclined from the back up to the front down.

The stirring head is connected with a lifting cross beam through a rotating rod and a bearing at the upper end of the stirring head, two ends of the lifting cross beam are connected with a paddle shaft conveying frame through a motor, a lifting shaft gear 91, a lifting motor gear 111 and a rack mechanism, and a pH value adjusting sampling port is arranged on the lifting cross beam. The lifting motor gear 111 is connected with an output shaft of the motor, the lifting motor gear 111 is meshed with a transmission gear 134 on a lifting shaft, the lifting shaft gear 91 is meshed with a rack mechanism, and the rack mechanism is arranged on a paddle shaft conveying frame; the motor and lift shaft 135 are disposed on the lift beam. The rack mechanism is not moved, and the lifting shaft gear 91 moves up and down along the rack mechanism to drive the lifting beam to lift.

One end of the lifting beam is provided with a transverse driving belt pulley, the driving belt pulley is connected with a motor shaft extending downwards from a motor above the driving belt pulley, and the motor is arranged on the lifting beam; each rotating rod is provided with a driven belt wheel which is connected with the driving belt wheel through a belt.

The upper end of the draft tube is connected with the lifting cross beam.

The upper end of the water injection pipe is connected with the lifting cross beam.

Each dissolution cup corresponds to a group of water suction and injection pipes, each group of water suction and injection pipes comprises a suction pipe and a water injection pipe which are arranged in parallel, and the upper ends of the water suction and injection pipes are fixed with the front upper ends of the lifting cross beams through double-head hoops.

The liquid adding part adopts the liquid adding pipe, and the lifting beam lower extreme is provided with dissolves out the bowl cover, and the bull stick passes and dissolves out the bowl cover center, is provided with the feed liquor hole on the dissolution bowl cover, and the feed liquor hole links to each other with the liquid adding pipe, and the liquid adding pipe links to each other with the liquid adding pump.

The dissolving cup cover adopts a polytetrafluoroethylene cover.

And the control signal input port of the liquid adding pump is connected with the control signal output port of the controller.

The liquid adding pump adopts an industrial injection pump.

The pH meter driving and calibrating assembly comprises a pH meter conveying frame and a pH adjusting part, wherein lower ends of two sides of the pH meter conveying frame are arranged on sliding rails on the frame, and a pH value detecting head capable of detecting the pH value of liquid in the dissolution cup in a lifting manner is arranged on the pH meter conveying frame.

Through pH meter conveying frame and slide rail, be convenient for pH value detects the front and back translation of head. The pH value detection head can be lifted to detect the pH value of the liquid in the dissolution cup, so that the pH value detection head can conveniently descend to enter the dissolution cup to detect the pH value and then ascend to move to a required position. The pH adjusting part is arranged, so that the pH value of the liquid in the dissolving cup can be conveniently adjusted.

The pH adjusting part comprises a pH adjusting pipe, and the pH adjusting pipe is connected with a pH adjusting inlet on a dissolving cup cover on the paddle shaft assembly.

And the detection signal output port of the pH value detection head is connected with the detection signal input port of the controller and the detection signal input port of the PLC through the pH transmitter.

The pH transmitter adopts a CM442-AAM1B8F010A+AK type transmitter.

The pH value detection head is arranged on a detection head traversing mechanism on the pH meter conveying frame through a detection head lifting mechanism, and the driving direction of the detection head traversing mechanism is perpendicular to the movement direction of the pH meter conveying frame.

The detection head lifting mechanism comprises a vertical pH value detection head bearing sleeve, the rear end of the pH value detection head bearing sleeve is connected with a vertical rack through a transverse connecting rod, the vertical rack is arranged in a vertical guide groove, the rack is meshed with a gear, the gear is connected with a motor, and the motor is arranged on the detection head transverse moving mechanism.

The detection head sideslip mechanism includes the slide, the motor sets up on the slide, and the slide lower extreme sets up on the slide rail, and the slide rail both ends are provided with driving pulley and driven pulley, and driving pulley passes through the belt with driven pulley and links to each other, and driving pulley links to each other with the motor, and slide one side is provided with the L form and links the board, and L form links the board lower extreme to link to each other with the belt.

The pH meter drive calibration assembly further includes a solution bearing component.

The solution bearing component comprises a bearing transverse plate, a plurality of solution bearing bottle bodies which are transversely arranged are arranged on the bearing transverse plate, and the arrangement direction of the bearing bottle bodies is perpendicular to the movement direction of the pH meter conveying frame.

The number of the bearing bottle bodies is three.

Two pH meter calibration liquids are respectively arranged in two bearing bottles close to the outer side in the three bearing bottles, and a potassium chloride solution is arranged in the other bearing bottle.

The pH meter drive calibration assembly further includes a pH meter cleaning component.

The pH meter cleaning component and the solution bearing component are arranged at two ends of a sliding rail of the detection head traversing mechanism.

The pH meter cleaning component adopts a cleaning cup body.

The cleaning cup body is internally provided with a cleaning nozzle which is connected with a cleaning pump.

And a control signal input port of a cleaning pump contactor of the cleaning pump is connected with a control signal output port of the PLC.

The control signal input port of the cleaning pump is connected with the control signal output port of the controller.

The lower end of the basket shaft conveying frame, the lower end of the paddle shaft conveying frame and the pH meter conveying frame are connected through a synchronous connecting plate, and the lower end of the synchronous connecting plate is arranged on a sliding rail on the frame; the upper portion is provided with the pH meter and carries frame translation slide rail around the synchronous even board, and pH meter carries frame translation slide rail lateral part around being provided with the rack of fore-and-aft direction, rack and pH meter carry the gear engagement of frame lower extreme, and the gear shaft links to each other with the motor on the pH meter carries the frame, and pH meter carries frame lower extreme to be provided with and carry frame translation slide rail complex slide around the pH meter.

The synchronous link plate middle part is provided with downwardly extending's drive plate, and the drive plate lower extreme links to each other with the belt, and driving pulley and driven pulley that set up on the frame are walked around respectively at the belt both ends, and driving pulley links to each other with the motor.

The dissolving cup adopts a hard glass or an inert material cup.

The stirring head is coated with an inert material layer.

The stirring head adopts an inverted isosceles trapezoid stirring head, the center of the stirring head is connected with a rotating rod at the upper end of the stirring head, and two sides of the stirring head are arc-shaped sides.

The bottom of the dissolution cup is a semicircular 1000ml cup-shaped container, the inner diameter is 102mm plus or minus 4mm, the difference between the maximum value and the minimum value of the inner diameter of the cylindrical part of the dissolution cup is not more than 0.5mm, and the height is 185mm plus or minus 25mm.

The controller and the PLC are used for controlling all the components, so that the degree of automation is high, and the operation is stable and reliable.

The controller adopts an STM32F405 controller.

The PLC adopts a dimension-S1200 type PLC.

The controller receives a detection signal of the temperature controller, and the temperature controller can adopt a temperature sensor which detects the temperature in the water tank. The PLC receives a control signal of the controller and controls the heating component in the water tank through the temperature contactor.

The brushless motor can be adopted by the motor for driving the medicine taking basket clamping head and the stirring head to rotate, and the brushless motor is suitable for continuous rotation for a long time. The motors of other parts can adopt stepping motors, and the stepping motors have high precision.

The brushless motor driver adopts a BLE2D60 type driver.

The power distribution part comprises a 5A direct current power supply module and a 10A direct current power supply module, wherein one end of the input end of the 10A direct current power supply module is respectively connected with a control loop strong current branching terminal X5-L and one end of a first switch of a contactor KM2, and the other end of the input end of the 10A direct current power supply module is respectively connected with the control loop strong current branching terminal X5-N and one end of a second switch of the contactor KM 2;

the other end of the contactor KM2 is respectively connected with one end of a fuse F1, one end of a fuse F4, one end of a contactor KM1 control end and one end of a contactor KM2 control end, the other end of the contactor KM2 control end is respectively connected with the other end of a contactor KM2 second switch, one end of the fuse F2, one end of a fuse F5 and one end of a main loop strong current switch through a control loop strong current switch, and the other end of the main loop strong current switch is connected with the other end of the contactor KM1 control end through a main loop emergency stop switch;

the zero line, the live line and the ground line are respectively and correspondingly connected with the other end of a fuse F1, the other end of a fuse F2 and one end of a fuse F3 through three-phase circuit breakers (air switches), the other end of the fuse F3 is respectively connected with the strong electric ground line branching terminals X3-1, X2-1 and X1-1 of the main circuit through a fuse F6 and a contactor KM1 third switch, the other end of the fuse F5 is respectively connected with the strong electric zero line branching terminals X3-2, X2-2 and X1-2 of the main circuit through a contactor KM1 second switch, and the other end of the fuse F4 is respectively connected with the strong electric fire line branching terminals X3-1, X2-1 and X1-1 of the main circuit through a contactor KM1 first switch;

the positive electrode of the output end of the 5A direct current power supply module is respectively connected with the uncontrolled 24V branching terminal X4-2 of the main loop and one end of a first switch of a contactor KM3, and the negative electrode of the output end of the 5A direct current power supply module is connected with the uncontrolled GND branching terminal X4-1 of the main loop and one end of a second switch of the contactor KM 3;

the positive electrode of the output end of the 10A direct current power supply module is connected with the 24V branching terminal X6-24V of the control loop, and the negative electrode of the output end of the 10A direct current power supply module is connected with the 24V branching terminal X6-GND of the control loop; the other end of the first switch of the contactor KM3 is respectively connected with the branch terminals X8-1 and X7-1 of the controlled part of the main loop 24V, and the other end of the second switch of the contactor KM3 is respectively connected with the branch terminals X8-2 and X7-2 of the main loop GND.

The three-phase breaker adopts a 20A three-phase breaker, fuses F1, F2 and F3 adopt 12A fuses, and fuses F4, F5 and F6 adopt 10A fuses.

The main circuit strong electric fire wire branching terminals X3-1, X2-1 and X1-1 comprise ten terminal heads which are transversely arranged, the main circuit strong electric zero wire branching terminals X3-2, X2-2 and X1-2 comprise ten terminal heads which are transversely arranged, the main circuit strong electric ground wire branching terminals X3-1, X2-1 and X1-1 comprise ten terminal heads which are transversely arranged, the main circuit uncontrolled branching terminals X4-1 and X4-2 comprise thirteen terminal heads which are transversely arranged, the control circuit strong electric branching terminal branching terminals X5-L, X-N comprise four terminal heads which are transversely arranged, the control circuit strong electric zero wire branching terminals X6-24V, X-GND comprise four terminal heads which are transversely arranged, and the control circuit 24V controlled part branching terminals X7-1, X8-2 and X7-2 comprise twelve terminal heads which are transversely arranged.

The air switch is used for protecting the whole power supply system, the main circuit strong current switch and the main circuit emergency stop switch control the main circuit 220V to supply power, and the control circuit strong current switch controls the control circuit 220V to supply power.

The 5A direct current power supply module and the 10A direct current power supply module are switching power supplies and respectively supply power for the control loop and the main loop 24V equipment. The main circuit 220V supplies the motor and the heating element. The main circuit 24V (controlled part) is controlled by the PLC, and when the PLC gives a power supply command, KM3 is closed, supplying the intake pump and the suction pump. The main circuit 24V (uncontrolled) will be powered after the main circuit switch is closed, supplying the syringe pump. The control loop 220V supplies the PLC and PH meter. The control loop 24V (uncontrolled) feeds the PLC module (non-PLC host), pump controller.

The control loop of the power distribution part is separated from the main loop and works independently. Because the main loop is provided with large-current equipment such as a motor, the start and stop of the main loop can cause the power supply system to generate larger fluctuation, and the separation can effectively reduce the interference of the main loop to the control loop.

The invention provides a complete overcurrent protection measure for a power distribution part. The power supply system is provided with the reliable air switch, and the inlet end of the main loop are provided with fuses, so that equipment damage caused by overcurrent when equipment fails can be effectively prevented.

The switching power supply with reliable power distribution part provides stable power supply for 24V equipment.

Four corners of the lower end of the frame are provided with a support Ma Lun.

The operation of the present invention will be described with reference to the accompanying drawings.

Preparing.

After starting up, the mechanical structure is reset, and the dissolution instrument completes the following steps;

the vacuum degasser degasifies and heats pure water, and the degassed pure water and a solvent placed in advance are prepared into a solution with a specified concentration;

the water in the water tank of the dissolution instrument starts to circulate and is heated to the specified temperature and then kept at a constant temperature.

Pulling the movable clamping part of the sampling clamp leftwards, then placing the sampling assembly, and loosening the movable clamping part to enable the movable clamping part to clamp the sampling assembly; six sampling components can be arranged on each sampling clamp, and sixteen sampling clamps can be arranged.

And (3) extracting a lofting slide way of the dissolution instrument, sequentially putting the sampling clamp into the lofting slide way, and pushing back the lofting slide way.

Opening the medicine box cover, placing medicines into the medicine baskets, sequentially placing the medicine baskets into the medicine storage turntables, placing eight medicine baskets on each medicine storage turntable, arranging six medicine storage turntables, and covering the medicine box cover.

Experimental procedure.

The paddle shaft assembly moves to be right above the water tank; lowering to cover the dissolution cup; starting a liquid adding pump, adding hydrochloric acid, and adding 750mL of hydrochloric acid solution into the dissolution cup through a side liquid adding pipe in the dissolution cup cover in the paddle shaft assembly; the shaft assembly is raised.

The medicine storage turntable rotates to enable the medicine basket placing through hole of the mark 1 to rotate to the medicine basket dropping hole, the medicine basket drops into the medicine basket bearing groove, the medicine basket conveying frame moves backwards, and meanwhile, the basket shaft conveying lifting rotating assembly moves forwards to the position above the medicine basket conveying mechanism; the medicine basket clamping head descends to clamp the medicine basket on the medicine basket clamping head; the medicine basket clamping head lifts with the medicine basket and moves to the upper part of the dissolving cup; the medicine basket conveying frame returns to the initial position.

The medicine basket clamp drops to enable the medicine basket to be immersed in the solution in the dissolution cup, and the rotating rod drives the medicine basket to rotate at a specified rotating speed.

When the sampling time is reached, the sampling manipulator descends, and simultaneously the manipulator opens to prepare for clamping the sampling clamp; the mechanical arm moves forward to clamp the sampling clamp; the mechanical arm lifts the sampling clamp and moves backwards to align with the sampling port of the basket shaft conveying lifting rotating assembly.

The mechanical arm moves downwards to enable the needle head of the sampling assembly to reach the sampling position; the drawing component draws the sampling component to begin sampling; and (5) lifting the mechanical arm after sampling, and placing the sampling clamp on the sampling carriage.

The lifting cross beam of the basket shaft conveying lifting rotating assembly is lifted, and the paddle shaft conveying frame of the paddle shaft assembly moves forward to the upper part of the dissolving cup.

The lifting cross beam of the paddle shaft assembly descends to cover the dissolution cup; starting a liquid adding pump, adding a sodium phosphate solution into the dissolution cup, and adding 250mL of the sodium phosphate solution into the dissolution cup through a side liquid adding pipe in the dissolution cup cover in the paddle shaft assembly; the stirring head is started to start stirring.

The pH meter is lifted from the potassium chloride solution in the bearing bottle and moved to align with the pH value adjusting sampling port of the first dissolving cup; and (3) lowering the pH value of the detection solution, and simultaneously adding HCL or NAOH into the dissolution cup through an inner side pH adjusting pipe in the dissolution cup cover until the pH value reaches a specified value.

The pH meter is moved out of the first dissolution cup and moved to the right end cleaning cup body position; the pH meter is lowered, the cleaning pump is started, and the pH meter is cleaned.

The pH meter is moved out of the cleaning cup body and moved to be aligned with the pH value adjusting sampling port of the second dissolving cup; adjusting the pH of the solution in the second dissolution cup; repeating the steps, and adjusting the pH value of the residual solution; and finally, the pH meter is washed and then is moved into a potassium chloride solution in a bearing bottle.

The lifting cross beam of the paddle shaft assembly is lifted, the paddle shaft assembly and the basket shaft conveying lifting rotating assembly move backwards, the medicine taking basket clamping head of the basket shaft conveying lifting rotating assembly descends, and the dissolution experiment is continued.

Repeating the step until the sampling time is reached, descending the sampling manipulator, and opening the manipulator to prepare for clamping the sampling clamp; the mechanical arm moves forward to clamp the sampling clamp; the mechanical arm lifts the sampling clamp and moves backwards to align with the sampling port of the basket shaft conveying lifting rotating assembly.

The mechanical arm moves downwards to enable the needle head of the sampling assembly to reach the sampling position; the drawing component draws the sampling component to begin sampling; and (5) lifting the mechanical arm after sampling, and placing the sampling clamp on a sampling sliding frame.

After the experiment is finished, the rotating rod of the medicine basket clamp head stops rotating, the lifting cross beam is lifted, the basket shaft conveying frame moves forwards, and the medicine basket conveying frame moves backwards until the medicine basket is clamped at the U-shaped medicine basket clamp falling port on the medicine basket conveying frame; the lifting cross beam of the basket shaft conveying lifting rotating assembly is lifted again, and the medicine basket is blocked by the U-shaped medicine basket blocking and falling opening and falls into the medicine basket falling and collecting assembly below.

The paddle shaft assembly moves backwards to enable the draft tube to be aligned with the dissolution cup, and meanwhile, the basket shaft conveying frame returns to the initial position; the lifting cross beam of the rotating paddle assembly descends to enable the suction pipe to contact the bottom of the cup, and the water pump connected with the suction pipe is started to suck out liquid in the dissolution cup.

A water pump connected with the water injection pipe is started to wash the dissolution cup; after a certain amount of clear water is added, the paddle shaft assembly and the basket shaft conveying lifting rotating assembly respectively dip the stirring head, the medicine taking basket clamping head and the rotating rod into water for rotating and cleaning; the paddle shaft assembly moves backwards to enable the suction pipe to be aligned with the dissolution cup, the lifting cross beam of the rotating paddle assembly descends to enable the suction pipe to be in contact with the bottom of the cup, and the water pump connected with the suction pipe is started to pump water in the dissolution cup.

Repeatedly starting a water pump connected with the water injection pipe to wash the dissolution cup; after a certain amount of clear water is added, the paddle shaft assembly and the basket shaft conveying lifting rotating assembly respectively dip the stirring head, the medicine taking basket clamping head and the rotating rod into water for rotating and cleaning; the paddle shaft assembly moves backwards to enable the draft tube to be aligned with the dissolution cup, the lifting cross beam of the rotating paddle assembly descends to enable the draft tube to be in contact with the cup bottom, the water pump connected with the draft tube is started to pump water in the dissolution cup until the stirring head, the drug taking basket clamp head and the rotating rod are completely washed.

Repeating the experimental steps until all the sample experiments are completed.

The experimental procedure described above is not only applicable to basket methods, but also to paddle methods. The difference is that when the medicine is put, the paddle method does not need to put the medicine basket, but the medicine is directly put into the medicine storage rotary table. The process of putting the medicine into the dissolution cup is changed into: the basket shaft conveying frame moves backwards until the front pull baffle of the movable bottom plate of the medicine basket bearing groove hooks the front upper frame of the dissolving cup, the basket shaft conveying frame continues to move backwards for a certain distance, the movable bottom plate is pulled away, and medicines are released into the dissolving cup. The basket shaft conveying frame moves forward, the movable bottom plate returns to the initial position under the action of the movable bottom plate reset spring, and the lower port of the medicine basket bearing groove is blocked.

The manipulator removes a sampling clamp from the lofting balladeur train at every turn, and the later sampling clamp moves backward under the effect of sampling clamp translation actuating mechanism, fills the position of sampling clamp before, and is up to all sampling clamps use up. Each time the manipulator is placed on the sampling carriage to a sampling clamp containing a test solution, the last sampling clamp is pushed to move forward by one sampling clamp until the sampling carriage is full. In the dissolution experiment process, if staff wants to remove the sampling clamp filled with the test solution, the sampling carriage can be directly pulled out to remove the test solution.

After the dissolution experiment is completed, the worker can pull out the medicine basket falling and collecting assembly, and put back the medicine basket falling and collecting assembly after taking out the used medicine basket.

The invention has high degree of automation, and can realize unattended operation and liberate personnel.

It should be understood that the foregoing detailed description of the present invention is provided for illustration only and is not limited to the technical solutions described in the embodiments of the present invention, and those skilled in the art should understand that the present invention may be modified or substituted for the same technical effects; as long as the use requirement is met, the invention is within the protection scope of the invention.

Claims

1. The sampling clamp comprises a drawing part for driving the sampling assembly to sample, a fixed clamping part and a movable clamping part which are transversely arranged, and is characterized in that the opposite surfaces of the fixed clamping part and the movable clamping part are clamping surfaces of the sampling assembly, and the movable clamping part transversely moves through an elastic reset mechanism and clamps the sampling assembly;

the sampling device comprises a sampling assembly, a clamping surface and a fixed clamping part, wherein the sampling assembly is provided with a plurality of fixed clamping parts and a plurality of movable clamping parts;

the sampling assembly adopts a needle tube type piston extraction structure; the drawing component comprises a lifting beam, a clamping groove is formed in the lifting beam corresponding to the upper end of the piston, and the lifting beam is connected with the bearing beam through a lifting mechanism;

2. The sampling clamp according to claim 1, wherein the lifting mechanism comprises a transverse pulling syringe motor arranged on a sliding seat of the sampling manipulator, an output shaft of the pulling syringe motor is connected with a pulling syringe gear, the pulling syringe gear is meshed with a vertical rack, and a pulling transverse plate is arranged at the lower end of the vertical rack corresponding to the lifting transverse beam.

3. The sampling clamp according to claim 1, wherein guide posts extending downwards are arranged on two sides of the lifting beam, guide sleeves are arranged on the bearing beam corresponding to the guide posts, and the guide posts penetrate through the guide sleeves.