CN109091728A - A kind of micro liquid syringe and the method that parenchymal tissue is injected - Google Patents
A kind of micro liquid syringe and the method that parenchymal tissue is injected Download PDFInfo
- Publication number
- CN109091728A CN109091728A CN201710646860.6A CN201710646860A CN109091728A CN 109091728 A CN109091728 A CN 109091728A CN 201710646860 A CN201710646860 A CN 201710646860A CN 109091728 A CN109091728 A CN 109091728A
- Authority
- CN
- China
- Prior art keywords
- negative pressure
- injection needle
- micro liquid
- inner cylinder
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3286—Needle tip design, e.g. for improved penetration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M2005/3201—Coaxially assembled needle cannulas placed on top of another, e.g. needles having different diameters
Abstract
The present invention relates to the field of medical instrument technology, more particularly to a kind of micro liquid syringe and the method that parenchymal tissue is injected, it includes negative pressure needle and negative pressure syringe, wherein, the negative pressure syringe includes inner barrel and outer barrel, the inner wall of the inner cylinder is fitted closely with injection needle tube, and the outer wall of the inner cylinder and the inner wall of the outer cylinder fit closely, and the inner cylinder under external force can be mobile relative to the outer cylinder and the injection needle tube；The negative pressure needle is connected to one end of the outer cylinder, and is set in the outside of injection needle, and there are gaps between the negative pressure needle and the injection needle.The present invention makes the parenchymal tissues such as vascular wall form bubbling using negative pressure, it can be good at control injection needle and penetrate the parenchymatous depth such as vascular wall, micro liquid is injected into the parenchymal tissues such as vascular wall by guarantee, is to be made that contribution outstanding the technical issues of how controlling the sympathetic or parasympathetic fibers being distributed on blood vessel to explore central nervous system.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of parenchymatous micro liquid such as blood vessel that is used for infuse
Emitter and the method that parenchymal tissue is injected.
Background technique
Blood pressure is the pressure of vasoactive wall when being flowed in the blood vessels by blood, and blood is pushed to flow in the blood vessels
Power.The change of this power, it is too low or too high, it may appear that low blood pressure or hypertension.Vascular endothelia be dispersed with it is sympathetic or
Parasympathetic fibers, these fibers are controlled by axoneuron, central nervous excitation or inhibition, and it is fine to will affect these nerves
Dimension release monoamine neurotransmitter, acetylcholine or norepinephrine, wherein norepinephrine vasoactive epithelium
Smooth muscle cell, smooth muscle cell contraction lead to vessel retraction, and blood pressure increases.However, central nervous system is how to control friendship
Sense and parasympathetic be not it is found that specific core group, neural circuitry, specific cell are known.Therefore it is done from blood vessel inverse
The neural circuitry between the core group that nerve fibre issues, or even tracking core group is found to label to be very important.
The reverse labelling technique of blood vessel directly can inversely mark disease to vascular wall injection PRV using micro liquid syringe
Poison took brain to be perfused, slice at seven days or so.The structure of existing micro liquid syringe is as shown in Figure 1, include injection needle
Cylinder 1', injection needle 2', thimble 3' and plunger 4', wherein the injection needle 2' is connected to the one end the injection needle tube 1', the top
Needle 3' is inserted into the injection needle tube 1', and can be moved along the length direction of the injection needle tube 1', and the thimble 3' is located at
One end inside the injection needle tube 1' is provided with the plunger 4', and the plunger 4' can be moved together with the thimble 3', and
In conjunction with the injection needle tube 1' inner wall air-tightness.
Traditional injection needle 2' is made of metal, and the internal diameter at tip can not penetrate tough and tensile blood vessel in 200um or so
Wall；Therefore the injection needle 2' made of being drawn as glass capillary, tip internal diameter can achieve 50um, although blood vessel can be penetrated
Wall, but vascular wall is penetrated readily through by virus injection into blood, it cannot get the result that blood vessel inversely marks.
Therefore, reverse labeled virus can be infused in the case where guaranteeing not by virus injection into blood by being badly in need of one kind
Inject the micro liquid syringe of vascular wall.
Summary of the invention
The purpose of the present invention is to provide a kind of micro liquid syringe and the methods injected to parenchymal tissue, with solution
The problem of injection needle certainly of the existing technology penetrates readily through the parenchymal tissues such as vascular wall.
To achieve this purpose, the present invention adopts the following technical scheme:
A kind of micro liquid syringe, comprising: negative pressure syringe and negative pressure needle, wherein the negative pressure syringe include inner cylinder and
Outer cylinder, inner wall and the injection needle tube of the inner cylinder fit closely, and the outer wall of the inner cylinder and the inner wall of the outer cylinder fit closely,
The inner cylinder under external force can be mobile relative to the outer cylinder and the injection needle tube；The negative pressure needle is connected to described
One end of outer cylinder, and it is set in the outside of injection needle, there are gaps between the negative pressure needle and the injection needle.
Preferably, one end formation flange handle that the inner cylinder is exposed.
Preferably, being provided between the inner cylinder and the outer cylinder and between the inner cylinder and the injection needle tube
Rubber stopper.
Preferably, the negative pressure needle is made of organic glass.
Preferably, the internal diameter at the tip of the negative pressure needle is 0.3mm-1mm.
Preferably, the material of the negative pressure syringe is glass or metal.
Preferably, being provided with scale value on the barrel of the injection needle tube.
Preferably, the internal diameter at the tip of the injection needle is 0.05mm-0.3mm.
Preferably, the injection needle is drawn by glass capillary.
The method that a kind of pair of parenchymal tissue is injected, this method use micro liquid syringe as described above, including
Following steps:
The tip of negative pressure needle is fitted in parenchymal tissue；
Outside pull inner cylinder keeps inner cylinder mobile relative to outer cylinder and injection needle tube, forms negative pressure in negative pressure needle, makes described
Parenchymal tissue, which is formed, to be bubbled；
Micro liquid in injection needle tube is injected into parenchymal tissue by the thimble of push injection needle.
Beneficial effects of the present invention:
Micro liquid syringe provided by the invention and the method injected to parenchymal tissue, make vascular wall using negative pressure
Etc. parenchymal tissues formed be bubbled, can be good at control injection needle penetrate the parenchymatous depth such as vascular wall, guarantee will be micro
Liquid injection enters in the parenchymal tissues such as vascular wall, for explore central nervous system be how to control be distributed on blood vessel it is sympathetic or secondary
The technical issues of sympathetic fiber, is made that contribution outstanding.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram for micro liquid syringe that the prior art provides；
Fig. 2 is the structural schematic diagram of micro liquid syringe provided by the invention；
Schematic diagram when Fig. 3 is the use of micro liquid syringe provided by the invention.
In figure:
1'- injection needle tube；2'- injection needle；3'- thimble；4'- plunger；
1- injection needle tube；2- injection needle；3- thimble；4- plunger；5- negative pressure syringe；6- negative pressure needle；7- parenchymal tissue；
51- inner cylinder；52- outer cylinder；
511- flange handle；
71- is bubbled.
Specific embodiment
Technical solution of the present invention is further illustrated with embodiment with reference to the accompanying drawing.It is understood that this place
The specific embodiment of description is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to
Convenient for description, in attached drawing, only the parts related to the present invention are shown and it is not all.
As shown in Fig. 2, the present invention provides a kind of micro liquid syringe, for parenchymatous micro liquids such as vascular walls
Injection, comprising: injection needle tube 1, injection needle 2, thimble 3, plunger 4, negative pressure syringe 5 and negative pressure needle 6, wherein injection needle 2 connect
In one end of injection needle tube 1, injection needle 2 is drawn by glass capillary；Thimble 3 is inserted into injection needle tube 1, and can be along showwing loving care for
The length direction for penetrating syringe 1 is mobile；Plunger 4 is set to one end that thimble 3 is located inside injection needle tube 1, and plunger 4 can be with thimble 3
It moves together, and in conjunction with 1 inner wall air-tightness of injection needle tube；Negative pressure syringe 5 includes inner cylinder 51 and outer cylinder 52, the inner wall of inner cylinder 51
It is fitted closely with injection needle tube 1, the inner wall of the outer wall and outer cylinder 52 of inner cylinder 51 fits closely, and inner cylinder 51 under external force can
It is mobile relative to outer cylinder 52 and injection needle tube 1；Negative pressure needle 6 is connected to one end of outer cylinder 52, and is set in the outside of injection needle 2,
There are gaps between negative pressure needle 6 and injection needle 2.Preferably, in the tip of the center face negative pressure needle 6 at the tip of injection needle 2
The heart.
Micro liquid syringe provided by the invention is such as schemed when carrying out micro liquid injection to parenchymal tissues such as vascular walls
Shown in 3, firstly, being fitted in the tip of negative pressure needle 6 in parenchymal tissue 7；Then, outside pull inner cylinder 51 keeps inner cylinder 51 opposite
It is mobile in outer cylinder 52 and injection needle tube 1, negative pressure is formed in negative pressure needle 6, so that parenchymal tissue 7 is formed hillock shape and is bubbled 71, at this point,
The tip of injection needle 2 penetrates in the parenchymal tissue 7 being bubbled at 71；Finally, thimble 3 is pushed, by the micro liquid in injection needle tube 1
It is injected into parenchymal tissue 7.
Parenchymal tissue 7 is formed using negative pressure and is bubbled 71, can be good at controlling the depth that injection needle 2 penetrates parenchymal tissue 7
Micro liquid is injected into parenchymal tissue 7 by degree, guarantee, is how to control the friendship being distributed on blood vessel to explore central nervous system
The technical issues of sense or parasympathetic fibers, is made that contribution outstanding.
Further, the exposed one end of inner cylinder 51 forms flange handle 511, and for being injected pump clamping, the present invention is provided
The injection process of micro liquid syringe completion is operated by syringe pump, syringe pump can guarantee that full stroke uniform is injected, and control precision
It is high.
Further, it to guarantee the compactness combined between inner cylinder 51 and outer cylinder 52, is set between inner cylinder 51 and outer cylinder 52
It is equipped with rubber stopper；In addition, to guarantee the compactness combined between inner cylinder 51 and injection needle tube 1, inner cylinder 51 and injection needle tube 1 it
Between be also equipped with rubber stopper.
Negative pressure needle 6 is made of organic glass, and the internal diameter at tip is 0.3mm-1mm and artery outer diameter is approximate；Negative pressure syringe 5
Material be glass or metal.Negative pressure needle 6 and negative pressure syringe 5 can be drawn by hand, can also use 3D printing technique system
It forms.
Injection needle 2 is drawn by glass capillary, and the internal diameter at the tip of injection needle 2 is 0.05mm-0.2mm.In addition,
The scale value for representing volume is provided on the barrel of injection needle tube 1, convenient for the volume of the liquid sucked in control injection needle tube 1.
Micro liquid syringe provided by the invention is other than it can be used for the parenchymatous micro-injection such as vascular wall, also
Entire syringe can be transformed by the internal diameter at the tip of adjusting negative pressure needle 6 and injection needle 2, for injecting cell etc.；It can also
To need to be initially formed the experiment for carrying out the injections such as liquid after negative pressure again for other.
Obviously, the above embodiment of the present invention is just for the sake of clearly illustrating examples made by the present invention, and being not is pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (10)
1. a kind of micro liquid syringe characterized by comprising negative pressure syringe (5) and negative pressure needle (6), wherein the negative pressure
Syringe (5) includes inner cylinder (51) and outer cylinder (52), and inner wall and the injection needle tube (1) of the inner cylinder (51) fit closely, described interior
The inner wall of the outer wall and the outer cylinder (52) of cylinder (51) fits closely, and the inner cylinder (51) under external force can be relative to institute
It states outer cylinder (52) and the injection needle tube (1) is mobile；The negative pressure needle (6) is connected to one end of the outer cylinder (52), and is arranged
There are gaps between the outside of injection needle (2), the negative pressure needle (6) and the injection needle (2).
2. micro liquid syringe according to claim 1, which is characterized in that the exposed one end of the inner cylinder (51) is formed
Flange handle (511).
3. micro liquid syringe according to claim 1, which is characterized in that the inner cylinder (51) and the outer cylinder (52)
Between and the inner cylinder (51) and the injection needle tube (1) between be provided with rubber stopper.
4. micro liquid syringe according to claim 1, which is characterized in that the negative pressure needle (6) is by organic glass system
At.
5. micro liquid syringe according to claim 1, which is characterized in that the internal diameter at the tip of the negative pressure needle (6)
For 0.3mm-1mm.
6. micro liquid syringe according to claim 1, which is characterized in that the material of the negative pressure syringe (5) is glass
Glass or metal.
7. micro liquid syringe according to claim 1, which is characterized in that set on the barrel of the injection needle tube (1)
It is equipped with scale value.
8. micro liquid syringe according to claim 1, which is characterized in that the internal diameter at the tip of the injection needle (2)
For 0.05mm-0.3mm.
9. micro liquid syringe according to claim 1, which is characterized in that the injection needle (2) is by glass capillary
It draws.
10. the method that a kind of pair of parenchymal tissue is injected, this method uses such as the described in any item micro liquid of claim 1-9
Body syringe, which comprises the steps of:
The tip of negative pressure needle (6) is fitted on parenchymal tissue (7)；
Outside pull inner cylinder (51) keeps inner cylinder (51) mobile relative to outer cylinder (52) and injection needle tube (1), in negative pressure needle (6)
Negative pressure is formed, the parenchymal tissue (7) is formed and is bubbled (71)；
The thimble (3) of push injection needle (2), the micro liquid in injection needle tube (1) is injected into parenchymal tissue (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710646860.6A CN109091728A (en) | 2017-08-01 | 2017-08-01 | A kind of micro liquid syringe and the method that parenchymal tissue is injected |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710646860.6A CN109091728A (en) | 2017-08-01 | 2017-08-01 | A kind of micro liquid syringe and the method that parenchymal tissue is injected |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109091728A true CN109091728A (en) | 2018-12-28 |
Family
ID=64796458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710646860.6A Pending CN109091728A (en) | 2017-08-01 | 2017-08-01 | A kind of micro liquid syringe and the method that parenchymal tissue is injected |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109091728A (en) |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JPH0924103A (en) * | 1995-07-10 | 1997-01-28 | Interventional Technol Inc | Catheter to inject fluid medicine into vessel wall |
| JPH1052435A (en) * | 1996-06-13 | 1998-02-24 | Eclipse Surgical Technol Inc | Heart muscle device during operation and stimulating method |
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| CN101495171A (en) * | 2005-03-30 | 2009-07-29 | 卢门德公司 | Catheter systems for crossing total occlusions in vasculature |
| US20130053792A1 (en) * | 2011-08-24 | 2013-02-28 | Ablative Solutions, Inc. | Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation |
| JP2014076386A (en) * | 2007-02-27 | 2014-05-01 | Koninklijke Philips Nv | Method and device for recording vascular structure during medical intervention |
| CN104334227A (en) * | 2012-07-25 | 2015-02-04 | 凸版印刷株式会社 | Manipulation tool for fluid injector using multi-microneedle device |
| CN104922769A (en) * | 2015-06-23 | 2015-09-23 | 中国人民解放军第四军医大学 | Negative-pressure injector with needle inserting depth controllable |
| CN105457148A (en) * | 2016-01-18 | 2016-04-06 | 浙江大学 | Pericardium injection administration device and method thereof |
| WO2017100140A2 (en) * | 2015-12-08 | 2017-06-15 | Ablative Solutions, Inc. | Apparatus for effective ablation and nerve sensing associated with denervation |
| CN206261903U (en) * | 2016-08-18 | 2017-06-20 | 王姗姗 | A kind of syringe |
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2017
- 2017-08-01 CN CN201710646860.6A patent/CN109091728A/en active Pending
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|---|---|---|---|---|
| CN1110320A (en) * | 1994-04-07 | 1995-10-18 | 丁群星 | Method and device for conversion of plant |
| JPH0924103A (en) * | 1995-07-10 | 1997-01-28 | Interventional Technol Inc | Catheter to inject fluid medicine into vessel wall |
| JPH1052435A (en) * | 1996-06-13 | 1998-02-24 | Eclipse Surgical Technol Inc | Heart muscle device during operation and stimulating method |
| CN1174745A (en) * | 1996-08-22 | 1998-03-04 | 陈隆雄 | Micro-dosage safety syringe |
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