CN109069478A - Z-亚丁基苯酞于活化自体免疫***的应用 - Google Patents

Z-亚丁基苯酞于活化自体免疫***的应用 Download PDF

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CN109069478A
CN109069478A CN201780028428.9A CN201780028428A CN109069478A CN 109069478 A CN109069478 A CN 109069478A CN 201780028428 A CN201780028428 A CN 201780028428A CN 109069478 A CN109069478 A CN 109069478A
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cell
injection
butylidenephthalide
medicament
monokaryon
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CN109069478B (zh
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苏鸿麟
林欣荣
韩鸿志
邱紫文
蔡昇峰
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Everfront Biotech Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
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    • A61K39/4643Vertebrate antigens
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    • AHUMAN NECESSITIES
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/47Brain; Nervous system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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Abstract

一种使用Z‑亚丁基苯酞(Z‑butylidenephthalide)于制造一药剂的用途,其中该药剂与单核球细胞合并使用于活化自体免疫***及治疗癌症的至少一种。

Description

PCT国内申请,说明书已公开。

Claims (17)

  1. PCT国内申请,权利要求书已公开。
CN201780028428.9A 2016-05-23 2017-05-16 Z-亚丁基苯酞于活化自体免疫***的应用 Active CN109069478B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662340246P 2016-05-23 2016-05-23
US62/340,246 2016-05-23
PCT/CN2017/084455 WO2017202227A1 (zh) 2016-05-23 2017-05-16 Z-亚丁基苯酞于活化自体免疫***的应用

Publications (2)

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CN109069478A true CN109069478A (zh) 2018-12-21
CN109069478B CN109069478B (zh) 2021-07-06

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US (1) US10688128B2 (zh)
EP (1) EP3466422B1 (zh)
JP (1) JP6824287B2 (zh)
CN (1) CN109069478B (zh)
ES (1) ES2850498T3 (zh)
TW (1) TWI640310B (zh)
WO (1) WO2017202227A1 (zh)

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Publication number Priority date Publication date Assignee Title
CN114945364A (zh) * 2020-01-14 2022-08-26 长弘生物科技股份有限公司 用于癌症治疗的组合及其应用

Citations (7)

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WO1994026875A1 (en) * 1993-05-18 1994-11-24 I.D.M. Immuno-Designed Molecules New macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
CN1503678A (zh) * 2001-04-26 2004-06-09 3 激活的外周血单核细胞在治疗癌症方面的应用
CN1943606A (zh) * 2005-10-08 2007-04-11 财团法人佛教慈济综合医院 用于治疗癌症的当归萃取物
EP2343051A3 (en) * 2010-01-05 2012-03-14 National Dong Hwa University Anti-cancer formulation
US20140065096A1 (en) * 2012-09-05 2014-03-06 Regen BioPharma, Inc. Cancer therapy by ex vivo activated autologous immune cells
CN105267205A (zh) * 2014-06-04 2016-01-27 中国医药大学 治疗胰脏癌的医药配方及其应用
WO2016014613A1 (en) * 2014-07-22 2016-01-28 The Trustees Of The University Of Pennsylvania Compositions and methods for cancer immunotherapy

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Publication number Priority date Publication date Assignee Title
SG121980A1 (en) * 2004-10-08 2006-05-26 Buddhist Tzu Chi General Hospi Angelicae sinensis extracts useful for treatment of cancers
EP1937250B1 (en) * 2005-05-24 2011-10-19 DSM IP Assets B.V. Ligustilide derivatives for the treatment of inflammatory disorders
JP2007082422A (ja) 2005-09-20 2007-04-05 Oncorex Inc 低酸素条件下において遊走能を有する樹状細胞、およびその利用
TWI331033B (en) * 2007-04-26 2010-10-01 Yangsen Biotechnology Co Ltd Composition for inhibiting no and/or prostaglandin e2 synthesis and uses thereof
TWI386203B (zh) * 2011-01-07 2013-02-21 Univ China Medical 治療腦癌或用以降低腦癌細胞對替莫唑胺之抗藥性之醫藥組合物及其應用

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026875A1 (en) * 1993-05-18 1994-11-24 I.D.M. Immuno-Designed Molecules New macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
CN1503678A (zh) * 2001-04-26 2004-06-09 3 激活的外周血单核细胞在治疗癌症方面的应用
CN1943606A (zh) * 2005-10-08 2007-04-11 财团法人佛教慈济综合医院 用于治疗癌症的当归萃取物
EP2343051A3 (en) * 2010-01-05 2012-03-14 National Dong Hwa University Anti-cancer formulation
US20140065096A1 (en) * 2012-09-05 2014-03-06 Regen BioPharma, Inc. Cancer therapy by ex vivo activated autologous immune cells
CN105267205A (zh) * 2014-06-04 2016-01-27 中国医药大学 治疗胰脏癌的医药配方及其应用
WO2016014613A1 (en) * 2014-07-22 2016-01-28 The Trustees Of The University Of Pennsylvania Compositions and methods for cancer immunotherapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
傅冰洁等: "肿瘤的细胞免疫治疗", 《中国处方药》 *
张迪: "当归的免疫药理作用研究", 《黑龙江科技信息》 *

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Publication number Publication date
EP3466422A1 (en) 2019-04-10
JP6824287B2 (ja) 2021-02-03
TWI640310B (zh) 2018-11-11
WO2017202227A1 (zh) 2017-11-30
CN109069478B (zh) 2021-07-06
US20170333478A1 (en) 2017-11-23
TW201740938A (zh) 2017-12-01
EP3466422A4 (en) 2020-03-11
ES2850498T3 (es) 2021-08-30
JP2019519482A (ja) 2019-07-11
US10688128B2 (en) 2020-06-23
EP3466422B1 (en) 2020-11-18

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