CN109065181A - A kind of multiple database exchange method and device based on wide in range retrieval - Google Patents
A kind of multiple database exchange method and device based on wide in range retrieval Download PDFInfo
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Abstract
The embodiment of the invention discloses a kind of multiple database exchange method and device based on wide in range retrieval, method includes: reception retrieval request, and retrieval request includes search key；It is made a variation according to retrieval request with disease gene and drug is interpreted multiple database interactive system and interacted, wide in range property retrieval is carried out in each database that disease gene makes a variation and drug interprets multiple database interactive system according to search key, each database disease gene variation Evidence grade relevant to drug is obtained according to the result of retrieval；Each database disease gene variation search result relevant to drug is scored according to the score value of correspondence database, and each data score is fed back into interpretation reporting device and is interpreted.Formula retrieval is interacted by the multiple database interactive system that genetic mutation and disease information database, medication data library and disease and variation documentation & info database form by establishing, retrieving is simple, and can obtain more acurrate and comprehensive search result.
Description
Technical field
The present embodiments relate to field of computer technology, and in particular to a kind of multiple database interaction based on wide in range retrieval
Method and device.
Background technique
As detected number of genes quicklys increase in Disease sample, clinical molecular laboratory testing is to increasingly
More new sequence variations.Certain illnesss and drug use are only related to individual gene mutation, and most illnesss and drug use
Related to multiple gene mutations, contacting between genetic mutation and drug interpretation is very close and complicated, gives sequencing to some
The clinical meaning of column variation carries out classification interpretation, establishes disease gene variation and drug data base.
But the genetic mutation data of the magnanimity generated with the continuous development of two generation sequencing technologies, huge gene
The processing and analysis of variation data and various forms data (drug, guide, clinical information, document etc.) are to realize that disease is precisely cured
The emphasis for the treatment of.Currently, there is no the unified standard interpreted about disease gene variation with drug and databases, for dependency basis
Because variation data interpretation and compile each major company and Clinical Institutions have different a processing method and process, therefore how
It establishes and improves and interactive disease gene variation and drug data base is facilitated to be a problem to be solved.
Summary of the invention
Since existing method is there are the above problem, the embodiment of the present invention proposes that a kind of multiple database based on wide in range retrieval is handed over
Mutual method and device.
In a first aspect, the embodiment of the present invention proposes a kind of multiple database exchange method based on wide in range retrieval, comprising:
The retrieval request of searching terminal is received, the retrieval request includes search key；
It is made a variation according to the retrieval request with disease gene and drug is interpreted multiple database interactive system and interacted, and root
It is carried out in each database that the disease gene makes a variation and drug interprets multiple database interactive system according to the search key
Wide in range property retrieval obtains each database disease gene variation Evidence grade relevant to drug according to the result of retrieval；
Each database disease gene variation search result relevant to drug is carried out according to the score value of correspondence database
Scoring, and each data score is fed back into interpretation reporting device and is interpreted；
Wherein, it includes genetic mutation that the disease gene variation and drug, which interpret each database of multiple database interactive system,
With disease information database, medication data library and disease and variation documentation & info database；The genetic mutation and disease
Sick information database is for storing genetic mutation and the relevant data of disease information；The medication data library is for storing medicine
The treatment-related data of object；The disease is to variation documentation & info database for storing disease number relevant with variation document
According to.
Optionally, the method also includes:
The interpretation reporting device interprets the search result of target database, generates and interprets report.
Optionally, the method also includes:
It interprets result statistic device and counts the disease gene variation evidence relevant to drug retrieved in each target database
The result of statistics is sent to the interpretation reporting device by the height of grade, and receives the solution that the interpretation reporting device is sent
It reads the newspaper announcement.
Second aspect, the embodiment of the present invention also propose a kind of multiple database interactive device based on wide in range retrieval, comprising:
Retrieval request receiving module, for receiving the retrieval request of searching terminal, the retrieval request includes that retrieval is crucial
Word；
Wide in range property retrieval module is handed over for interpreting multiple database according to the retrieval request and disease gene variation and drug
Mutual system interacts, and make a variation according to the search key in the disease gene and drug interprets multiple database interaction and is
Wide in range property retrieval is carried out in each database of system, each database disease gene variation and drug phase are obtained according to the result of retrieval
The Evidence grade of pass；
Evidence grade judgment module, for by each database disease gene make a variation relevant to drug search result according to
The score value of correspondence database scores, and each data score is fed back to interpretation reporting device and is interpreted；
Wherein, it includes genetic mutation that the disease gene variation and drug, which interpret each database of multiple database interactive system,
With disease information database, medication data library and disease and variation documentation & info database；The genetic mutation and disease
Sick information database is for storing genetic mutation and the relevant data of disease information；The medication data library is for storing medicine
The treatment-related data of object；The disease is to variation documentation & info database for storing disease number relevant with variation document
According to.
Optionally, described device further include:
Read through model is solved, is interpreted for the search result to target database, generates and interprets report.
Optionally, described device further include:
Statistical module, for counting the disease gene retrieved in each target database variation evidence relevant to drug etc.
Grade, counts the height of each Evidence grade, the result of statistics is sent to the interpretation reporting device, and receives the interpretation report
The interpretation report that device is sent.
The third aspect, the embodiment of the present invention also propose a kind of electronic equipment, comprising:
At least one processor；And
At least one processor being connect with the processor communication, in which:
The memory is stored with the program instruction that can be executed by the processor, and the processor calls described program to refer to
Order is able to carry out the above method.
Fourth aspect, the embodiment of the present invention also propose a kind of non-transient computer readable storage medium, the non-transient meter
Calculation machine readable storage medium storing program for executing stores computer program, and the computer program makes the computer execute the above method.
As shown from the above technical solution, the embodiment of the present invention is by establishing by genetic mutation and disease information database, medicine
Object treatment data library and disease and the multiple database interactive system of variation documentation & info database composition interact formula retrieval,
Retrieving is simple, and can obtain more acurrate and comprehensive search result.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
Other attached drawings are obtained according to these figures.
Fig. 1 is that a kind of disease gene variation that one embodiment of the invention provides and drug interpret multiple database interactive system
Connection schematic diagram；
Fig. 2 be another embodiment of the present invention provides a kind of disease gene variation and drug interpret multiple database interactive system
Connection schematic diagram；
Fig. 3 is a kind of flow diagram for multiple database exchange method that one embodiment of the invention provides；
Fig. 4 is a kind of process signal for more data interactive methods based on wide in range retrieval that one embodiment of the invention provides
Figure；
Fig. 5 is a kind of flow diagram of multiple database for providing of one embodiment of the invention successively exchange method；
Fig. 6 is a kind of structural representation for multiple database interactive device based on wide in range retrieval that one embodiment of the invention provides
Figure；
Fig. 7 is the logic diagram for the electronic equipment that one embodiment of the invention provides.
Specific embodiment
With reference to the accompanying drawing, further description of the specific embodiments of the present invention.Following embodiment is only used for more
Technical solution of the present invention is clearly demonstrated, and not intended to limit the protection scope of the present invention.
Fig. 1 shows a kind of disease gene variation provided in this embodiment and drug interprets multiple database interactive system, packet
It includes: genetic mutation and disease information database 101, medication data library 102 and disease and variation documentation & info database
103。
The genetic mutation and disease information database 101, the medication data library 102 and the disease and variation
Documentation & info database 103 connects two-by-two respectively.
The genetic mutation and disease information database 101 are for storing genetic mutation and the relevant data of disease information.
The medication data library 102 is for storing the relevant data of drug therapy.
The disease is to variation documentation & info database 103 for storing disease data relevant with variation document.
Wherein, the medication data library includes: disease and genetic mutation and drug therapy approval in-formation database, disease
Disease and genetic mutation and drug therapy Consensus of experts information database and disease and genetic mutation and drug therapy clinical trials
Information database.
The present embodiment is by establishing by genetic mutation and disease information database, medication data library and disease and change
Different article offers the multiple database interactive system of information database composition, for storing genetic mutation and drug related data, the majority
It is improved according to library interactive system data volume and easy to use.
Further, on the basis of the above embodiments, the system also includes: interpret reporting device and retrieval interpret knot
Fruit statistic device.
The interpretation reporting device respectively with the genetic mutation and disease information database, the medication data library
It is connect with the disease with variation documentation & info database, for being interpreted to received judging result, generates and interpret report.
The interpretation result statistic device respectively with the genetic mutation and disease information database, the drug therapy number
It connect according to library, the disease with variation documentation & info database and the interpretation reporting device, is examined for counting in each database
The disease gene variation Evidence grade relevant to drug of rope, judges that the height of the Evidence grade obtains judging result, by institute
It states judging result and is sent to the interpretation reporting device, and receive the interpretation report of the interpretation reporting device feedback.
Specifically, the present embodiment amounts to 6 databases, result statistic device is interpreted in 1 retrieval and 1 interpretation report dress
It sets, all of above device constitutes complete disease gene variation and drug multidatabase system.It wherein, include 1 in 6 databases
A Primary database is genetic mutation and disease information database, and it includes three parts, first part is genetic mutation information
Database, second part are disease information database, and Part III is disease medicament information database；1 second databases is
Medication data library, includes three subdata bases, referred to as three-level database in medication data library, as shown in Figure 2
Three-level database 1, three-level database 2 and three-level database 3, specifically comprising disease and genetic mutation and drug therapy approval in-formation
Database, disease and genetic mutation are faced with drug therapy Consensus of experts information database, disease and genetic mutation and drug therapy
Bed Test Information database；1 level Four database disease and variation documentation & info database, as shown in Figure 2.Result is interpreted in retrieval
Statistic device be responsible for count second databases, three-level database, level Four database retrieval disease gene variation it is related to drug
Evidence grade, and judge the height of Evidence grade, according to judgement as a result, instruction to the Primary database that feedback continues retrieval continues
Retrieving or feedback result are completed to interpreting reporting device, and obtains and interprets the interpretation report that reporting device is sent, completes solution
Read procedure；It interprets reporting device and is responsible for reception retrieval interpretation result statistic device instruction, complete finally to interpret, formation solution is read the newspaper
It accuses, completes solution read procedure.
Wherein, Evidence grade be in medical domain for preventing, diagnosing, prognosis, treatment and harm research etc. evaluation etc.
Grade, such as a set of Evidence grade that Oxford Evidence-Based Medicine Center proposes includes A grades of evidences, B grades of evidences, C grades of evidences and D grades of cards
According to: Randomized controlled clinical study that A grades of evidences indicate consistent, are verified in different groups, cohort study, complete
Or without the research of conclusion formula, clinical decision rule；B grades of evidences indicate consistent retrospective cohort study, perspective queue
The conclusion that research, ecological Journal of Sex Research, outcome research, case-control study or the extrapolation of A grades of evidences obtain；C grades of evidences indicate
The conclusion that the research of case sequence or B grades of evidences extrapolations obtain；D grades of evidences indicate the expert opinion of no key evaluation, or
The evidence obtained based on basic medical research.
It is as follows that wherein there are correlations between 6 databases:
Wherein, Primary database is genetic mutation database, and second databases (the first level unscrambling data library) are drug
Treatment data library, three-level database include: approval data library (the second level unscrambling data library), common recognition database (third level
Unscrambling data library) and clinical testing data library (the 4th level unscrambling data library), level Four database is disease and variation document letter
It ceases in database (layer 5 grade unscrambling data library).
Further, on the basis of the above embodiments, the genetic mutation and disease information database include that gene becomes
Different information database, disease information database, disease medicament information database.
The genetic mutation information database is selected from the group below one or more for storing: Gene Name, gene function
Background introduction, chromosome location, transcript number, genetic mutation RS, signal path, genetic mutation nucleotide diversity locating for gene
Information, genetic mutation amino acid variation information, sequence variations are in nucleotide and amino acid levels function prediction result.
The disease information database for store it is selected from the group below one or more: disease happening part, disease name,
Occurrence cause, genius morbi, diagnostics method and index.
The disease medicament database is selected from the group below one or more for storing: disease therapeuticing medicine, including chemistry
Other new types of therapeutic agents such as drug, target therapeutic agent, immunotherapy medicaments, gene therapy medicament
Specifically, genetic mutation information database includes Gene Name, gene function background introduction, locating dyeing position
It sets, signal path locating for transcript number, genetic mutation RS, gene, genetic mutation nucleotide diversity information (coding), gene
Variant amino acid makes a variation information (protein), sequence variations are in nucleotide and amino acid levels function prediction result etc..Its information
Retrieval mode is keyword: disease, is examined in each demographic data library, disease specific database and sequence database
Rope, including but not limited to EAC, EVS, 1000 Genomes Project, dbSNP, dbVar, ClinVar, OMIM, Human
Gene Mutation Database、Human Genome Variation Society、Leiden Open Variation
Database、DECIPHER、NCBI、RefSeqGene、Locus Reference Genomic(LRG)、MitoMap。
Disease information database includes but is not limited to disease happening part, disease name, occurrence cause, genius morbi, examines
The disconnected related contents such as method and index.
Further, on the basis of the above embodiments, the disease and genetic mutation and drug therapy approval in-formation number
It is selected from the group below one or more for storing according to library: Trade-name of drug, adopted name, indication information, application method, no
Good response data.
The disease and genetic mutation and the information retrieval level of drug therapy approval in-formation database are including two layers, first
Layer is disease and genetic mutation information, and the second layer is genetic mutation information.
Specifically, the content stored in disease and genetic mutation and drug therapy approval in-formation database includes drug commodity
Title, adopted name, indication information, application method, dosage and management, contraindication, warning and precautionary measures, adverse reaction number
According to, drug interaction and it is specific use crowd's information, information retrieval level is two layers, and first layer is disease+genetic mutation
Information, the second layer are genetic mutation information, are retrieved in each food and medicine Surveillance Authority database and drug data base,
Including but not limited to CFDA, FDA, EMA, PMDA.
Further, on the basis of the above embodiments, the disease and genetic mutation and drug therapy Consensus of experts are believed
Breath database is used to store diagnosis, treatment, monitoring and/or the prognosis information used with genetic mutation drug.
The disease and genetic mutation and the information retrieval level of drug therapy Consensus of experts information database include two layers,
First layer is disease and genetic mutation information, and the second layer is genetic mutation information.
Specifically, the content stored in disease and genetic mutation and drug therapy Consensus of experts information database includes recommending
The diagnosis used with genetic mutation drug, treatment, monitoring, prognosis information etc..Its information retrieval level is two layers, first layer
For disease+genetic mutation information, the second layer is genetic mutation information, retrieves, wraps in each accomplished expert's guide common recognition database
Include but be not limited to NCCN, ASCO, CSCO, ESMO, each disease Consensus of experts.
Further, on the basis of the above embodiments, the disease and genetic mutation and drug therapy clinical trials are believed
Breath database is for storing completed clinical test and the clinical trial information in recruitment, including one selected from the group below or more
: clinical research number, research title, research approach, mutation detection method, sample size, crowd characteristic, result of study and research
Conclusion；
The disease and genetic mutation and the information retrieval level of drug therapy clinical trials information database include two layers,
First layer is disease and genetic mutation information, and the second layer is genetic mutation information.
Specifically, the content stored in disease and genetic mutation and drug therapy clinical trials information database includes complete
At clinical test and in the clinical trial information of recruitment, content includes selected from the group below one or more: clinical research number,
Study title, research approach, mutation detection method, sample size, crowd characteristic, result of study, research conclusion, information retrieval
Level is two layers, and first layer is disease+genetic mutation information, the second layer be genetic mutation information, clinical testing data library into
Row inquiry, including but not limited to Clinicaltrails, medicine intelligence net, medicine cross net etc..
Further, on the basis of the above embodiments, the disease and variation documentation & info database are for storing choosing
From the one or more of the following group: periodical title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size,
Result of study, research conclusion, identification number PMID and the periodical IF factor.
The disease and the information retrieval level of variation documentation & info database include two layers, and first layer is disease and gene
Make a variation information, and the second layer is genetic mutation information.
Specifically, the content that stores includes one selected from the group below or more in the disease and variation documentation & info database
: periodical title, tumor type, genetic mutation information, detection method, crowd characteristic, sample size, result of study, research knot
By, PMID (ID number of PubMed document), the periodical IF factor, information retrieval level be two layers, first layer is disease+gene
Make a variation information, and the second layer is genetic mutation information, is retrieved in major bibliographic data base, including but not limited to pubmed, paddy
Sing science etc..
The present embodiment interprets multiple database interactive system with drug by establishing disease gene variation relevant to disease, is
The genetic mutation and drug of disease interpret interpretation standard, process and the model established.Can be quick with the multidatabase system,
Accurately each variation is interpreted by different levels, interpretation standard is harsh to have science, is applicable to the essence of disease
Quasi- treatment.
Fig. 3 shows a kind of flow diagram of multiple database exchange method provided in this embodiment, comprising:
S301, the retrieval request for receiving searching terminal, the retrieval request includes search key.
S302, it is handed over according to the retrieval request and disease gene variation and drug interpretation multiple database interactive system
Mutually, it and is made a variation according to the search key in the disease gene and drug is interpreted in multiple database interactive system and examined
Rope obtains disease gene variation and drug evidence.
Wherein, it includes genetic mutation and disease information that the disease gene variation and drug, which interpret multiple database interactive system,
Database, medication data library and disease and variation documentation & info database；The genetic mutation and disease information data
Library is for storing genetic mutation and the relevant data of disease information；The medication data library is for storing drug therapy correlation
Data；The disease is to variation documentation & info database for storing disease data relevant with variation document.
S303, the default correlation table of inquiry obtain the correlation of disease gene variation and drug evidence, by the correlation
It is compared with clinical direct drug injection standard, obtains comparison result.
S304, according to the comparison result, execute corresponding operation.
Wherein, the default correlation table is the mapping for storing disease gene variation and the correlation between drug evidence
Table.
The present embodiment is by establishing by genetic mutation and disease information database, medication data library and disease and change
The multiple database interactive system that different article offers information database composition interacts formula retrieval, and retrieving is simple, and can obtain
More acurrate and comprehensive search result.
Further, on the basis of above method embodiment, S304 is specifically included:
If the correlation is less than the clinical direct drug injection standard, trigger continuation search instruction, and according to it is described after
Continuous search instruction is retrieved.
In another embodiment, S304 is specifically included:
If the correlation is more than or equal to the clinical direct drug injection standard, according to disease gene variation and drug
Evidence provides corresponding report.
Specifically, in more data exchange process, there are two types of processing modes:
The first data interactive processing method is that generality carries out wide in range property retrieval to all database, is obtained each
The Evidence grade of database, feature are that time-consuming for interpretation process, interpret result broad covered area, the Evidence grade result of crawl is not
Prominent, specifically include: Primary database, i.e. genetic mutation and disease information database receive former as DIALOG information retrieval database DIALOG
Beginning search instruction 0, and initiate the request of searching database device；By coordinate indexing entry, in second databases and four series
According to being retrieved in library, disease gene variation and drug evidence are obtained, result is directly fed back into report solution read apparatus, completes solution
It reads.
The first more data interactive method based on wide in range retrieval specifically includes following steps, as shown in Figure 4:
S401, the retrieval request for receiving searching terminal, the retrieval request includes search key；
S402, it is handed over according to the retrieval request and disease gene variation and drug interpretation multiple database interactive system
Mutually, and according to the search key the disease gene make a variation and drug interpret multiple database interactive system each database
It is middle to carry out wide in range property retrieval, each database disease gene variation evidence relevant to drug etc. is obtained according to the result of retrieval
Grade；
If S403, Evidence grade are greater than preset value, the database that Evidence grade is greater than preset value is determined as number of targets
According to library, and the search result of target database is fed back into interpretation reporting device and is interpreted；
Wherein, it includes genetic mutation that the disease gene variation and drug, which interpret each database of multiple database interactive system,
With disease information database, medication data library and disease and variation documentation & info database；The genetic mutation and disease
Sick information database is for storing genetic mutation and the relevant data of disease information；The medication data library is for storing medicine
The treatment-related data of object；The disease is to variation documentation & info database for storing disease number relevant with variation document
According to.
The wide in range property retrieval refers to all data that multiple database interactive system is interpreted to disease gene variation and drug
Library is retrieved, and each database does not set specific sorted order.
The purpose of wide in range property retrieval is in order to obtain all and gene and disease relevant information, so big without evidence value
In the setting of preset value, wide in range property retrieval is defined as retrieving some genetic mutation all databases, obtains corresponding data
The relevant evidence in library, and be compared according to the default grade form of correspondence database, it obtains all genetic mutation and drug and demonstrate,proves
According to relationship, include it is high, medium and low on evidence after, search result is fed back to and interprets reporting device and interprets.
The present embodiment is by establishing by genetic mutation and disease information database, medication data library and disease and change
The multiple database interactive system that different article offers information database composition interacts formula retrieval, and retrieving is simple, and can obtain
More acurrate and comprehensive search result.
More data interactive methods of the above method based on wide in range retrieval can also include:
S404, the interpretation reporting device interpret the search result of target database, generate and interpret report.
It is relevant to drug that S405, interpretation result statistic device count the disease gene variation retrieved in each target database
The result of statistics is sent to the interpretation reporting device by the height of Evidence grade, and is received the interpretation reporting device and sent
Interpretation report.
Second of data interactive processing method is, according to disease gene variation and the data in the device of drug unscrambling data library
Evidence grade height in library successively carries out data interaction processing to drug gene variation correlation, and advantage is that can effectively shorten interpretation
Process grabs most efficient evidence, improves the accuracy for interpreting result.
Successively exchange method specifically includes following steps to second of multiple database, as shown in Figure 5:
S501, the original search instruction for receiving searching terminal, the original search instruction includes search key；
S502, the progress of multiple database interactive system is interpreted according to the original search instruction and disease gene variation and drug
Interaction, and according to the search key the disease gene make a variation and drug interpret multiple database interactive system gene change
It is examined in different and disease information database genetic mutation information database, disease information database and disease medicament database
Rope obtains list of medications；
S503, it is criticized according to the list of medications and the search key in the disease and genetic mutation and drug therapy
It is retrieved in calibration information database, and presets correlation table according to the result queries of retrieval and obtain disease gene variation and drug
First correlation of evidence；
If S504, first correlation are less than clinical direct drug injection standard, triggering first continues search instruction, and root
According to the first continuation search instruction and the search key makes a variation in the disease gene and drug is interpreted multiple database and handed over
It is retrieved in the disease and genetic mutation and drug therapy Consensus of experts information database of mutual system, and according to first phase
Closing property and the result queries of retrieval preset correlation table and obtain the second correlation of disease gene variation and drug evidence；
If S505, second correlation are less than clinical direct drug injection standard, triggering second continues search instruction, and root
According to the second continuation search instruction and the search key makes a variation in the disease gene and drug is interpreted multiple database and handed over
It is retrieved in the disease and genetic mutation and drug therapy clinical trials information database of mutual system, and according to second phase
Closing property and the result queries of retrieval preset correlation table and obtain the third correlation of disease gene variation and drug evidence；
If S506, the third correlation are less than the clinical direct drug injection standard, trigger third and continues search instruction,
And continue that search instruction and the search key make a variations in the disease gene and drug interprets majority evidences according to the third
It is retrieved in the disease of library interactive system and variation documentation & info database, obtains final search result；
If S507, first correlation/second correlation/third correlation are more than or equal to clinical directly use
Medicine standard then interprets disease gene variation and drug.
The present embodiment is by establishing by genetic mutation and disease information database, medication data library and disease and change
The multiple database interactive system that different article offers information database composition interacts formula retrieval, and retrieving is simple, and can obtain
More acurrate and comprehensive search result.
Wherein, S504 is specifically included:
If first correlation is less than clinical direct drug injection standard, triggering first continues search instruction, and according to institute
State the first continuation search instruction and the search key the disease gene make a variation and drug interpret multiple database interaction system
It is retrieved in the disease and genetic mutation of system and drug therapy Consensus of experts information database, obtains disease gene variation and medicine
Material evidence evidence feeds back to the genetic mutation and disease information database, by the genetic mutation and disease information database generalization
It is fed back to after the search result in medication data library and interprets result statistic device, and inquired according to the search result of current composite
Default correlation table obtains the second correlation of disease gene variation and drug evidence.
S506 is specifically included:
If the interpretation result statistic device judgement knows that the third correlation is less than the clinical direct drug injection standard,
It then triggers third and continues search instruction to interpreting reporting device, and search instruction and retrieval key are continued according to the third
Word the disease gene make a variation and drug interpret multiple database interactive system disease and variation documentation & info database in into
Row retrieval, obtains final search result.
Above-mentioned multiple database successively exchange method further include:
If S505, judgement know that the final search result is less than the clinical direct drug injection standard, feed back third after
Continue search instruction to the genetic mutation and disease information database.
In practical interactive process kind, Primary database, i.e. genetic mutation and disease information database, as information retrieval number
According to library, receive original search instruction 0, and initiates the request of searching database device；It is preferential two by coordinate indexing entry
Grade database, i.e., retrieved in second level unscrambling data library, obtains disease gene variation and drug evidence, and feed back to first
Result statistic device is interpreted in level unscrambling data library and retrieval；Result statistic device is interpreted in retrieval, judges the disease currently retrieved
The correlation of genetic mutation and drug evidence assigns No. 1 interpretation report instruction to interpretation report if reaching medication clinical criteria
Device；If not up to clinical direct drug injection standard, feedback continues to retrieve information to DIALOG information retrieval database DIALOG, and sending continues to retrieve
Instruction 1.
It interprets report instruction for No. 1 and refers to that interpretation reporting device can grab the disease gene variation currently retrieved and demonstrate,prove with drug
It according to data, generates and interprets report, and terminate entire solution read procedure.
Continue search instruction 1 to refer to through DIALOG information retrieval database DIALOG, successively carry out the retrieval in third level unscrambling data library,
And obtain the process of disease gene variation and drug evidence.
Processing continue search instruction 1 the following steps are included:
Primary database, i.e. genetic mutation and disease information database, as DIALOG information retrieval database DIALOG, receiving continues to retrieve
Instruction 1 and the request for initiating to continue searching database device.
It is preferential in second databases by coordinate indexing entry, i.e., it is retrieved, is obtained in third level unscrambling data library
Disease gene variation and drug evidence, and the first level unscrambling data library is fed back to, the first level unscrambling data library comprehensive second
After level interprets result, feeds back to retrieval and interpret result statistic device.
Result statistic device is interpreted in retrieval, judges that the first level of current composite and the disease gene of the second level retrieval become
The different correlation with drug evidence assigns No. 2 interpretation report instructions to interpretation reporting device if reaching medication clinical criteria；
If not up to clinical direct drug injection standard, feedback continues to retrieve information to DIALOG information retrieval database DIALOG, issues and continues search instruction
2。
It interprets report instruction for No. 2 and refers to that interpretation reporting device can grab the disease gene variation currently retrieved and demonstrate,prove with drug
It according to data, generates and interprets report, and terminate entire solution read procedure.
Continue search instruction 2 to refer to through DIALOG information retrieval database DIALOG, successively carry out the retrieval in the 4th level unscrambling data library,
And obtain the process of disease gene variation and drug evidence.
Processing continue search instruction 2 the following steps are included:
Primary database, i.e. genetic mutation and disease information database, as DIALOG information retrieval database DIALOG, receiving continues to retrieve
Instruction 2 and the request for initiating to continue searching database device.
It is preferential in second databases by coordinate indexing entry, i.e., it is retrieved, is obtained in fourth stage unscrambling data library
Disease gene variation and drug evidence, and the first level unscrambling data library is fed back to, the first level unscrambling data library comprehensive second
After level, third level interpret result, feeds back to retrieval and interpret result statistic device.
Result statistic device is interpreted in retrieval, judges the first level of current composite, the second level, the disease of third level retrieval
The correlation that ospc gene makes a variation with drug evidence assigns No. 3 interpretation report instruction to solutions and reads the newspaper if reaching medication clinical criteria
Accuse device；If not up to clinical direct drug injection standard, feedback continues to retrieve information to DIALOG information retrieval database DIALOG, and sending continues to examine
Suo Zhiling 3.
No. 3 interpretations report instruction is assigned to refer to, interpret reporting device can grab the disease gene variation that currently retrieves with
Drug proof data generates and interprets report, and terminates entire solution read procedure.
The continuation search instruction 3 refers to, by DIALOG information retrieval database DIALOG, successively carries out layer 5 grade unscrambling data library
Retrieval, and obtain disease gene variation and the process of drug evidence.
Processing continue search instruction 3 the following steps are included:
Primary database, i.e. genetic mutation and disease information database, as DIALOG information retrieval database DIALOG, receiving continues to retrieve
Instruction 3 and the request for initiating to continue searching database device；
It is preferential in level Four database by coordinate indexing entry, i.e., it is retrieved, is obtained in level V unscrambling data library
Disease gene variation and drug evidence, and the first level unscrambling data library is fed back to, the first level unscrambling data library comprehensive second
After level, third level are interpreted, the 4th level interprets result, feeds back to retrieval and interpret result statistic device.
Result statistic device is interpreted in retrieval, judges the correlation of the disease gene currently retrieved variation and drug evidence, if
Reach medication clinical criteria, then assigns No. 4 interpretation report instructions；If not up to clinical direct drug injection standard, assigns No. 5 solutions and reads the newspaper
Accuse instruction.
It interprets report instruction for No. 4 and refers to the disease gene variation and drug evidence number for interpreting that reporting device can be retrieved currently
According to, it generates and interprets report, the entire solution read procedure of end.
It interprets report instruction for No. 5 and refers to the disease gene variation and drug evidence number for interpreting that reporting device can be retrieved currently
According to, it generates and interprets report, the entire solution read procedure of end.
For example, for message processing module to search instruction 0, the search result of appearance is as follows:
For the search result of search instruction 0, Information Statistics module criterion is score value >=50 point, triggers No. 1 interpretation
Report instruction, no person, which triggers, continues search instruction 1.
For message processing module to search instruction 1 is continued, the search result of appearance is as follows:
For the search result of search instruction 1, Information Statistics module criterion is score value >=50 point, triggers No. 2 interpretations
Report instruction, no person, which triggers, continues search instruction 2.
For message processing module to search instruction 2 is continued, the search result of appearance is as follows:
For the search result of search instruction 2, Information Statistics module criterion is score value >=50 point, triggers No. 3 interpretations
Report instruction, no person, which triggers, continues search instruction 3.
For message processing module to search instruction 3 is continued, the search result of appearance is as follows:
For the search result of search instruction 3, Information Statistics module criterion is score value >=50 point, triggers No. 4 interpretations
Report instruction, no person touch No. 5 interpretation report instructions.
Wherein, the second level unscrambling data library-drug indication (CFDA) consistent with genetic mutation information is denoted as CS2；The
Two level unscrambling data libraries-drug indication (other) consistent with genetic mutation information is denoted as OS2；Second level unscrambling data
Library-drug indication and genetic mutation information inconsistent (CFDA) are denoted as CN2；Second level unscrambling data library-drug indication
(other) consistent with genetic mutation information are denoted as ON2；Third level unscrambling data library-drug indication and genetic mutation information one
(country) is caused to be denoted as CS3；Third level unscrambling data library-drug indication (other) consistent with genetic mutation information is denoted as OS3；
Third level unscrambling data library-drug indication and genetic mutation information inconsistent (country) are denoted as CN3；Third level interprets number
ON3 is denoted as according to library-drug indication (other) consistent with genetic mutation information.
Final score value evaluation is as follows:
Genetic mutation relevant to disease and drug unscrambling data library can be established using exchange method provided in this embodiment,
Interpretation standard, process and the model established are interpreted for the genetic mutation and drug of disease；With the multiple database exchange method and
System can quickly and accurately be interpreted each variation by different levels, and interpretation standard is harsh to have science, can
Accurate treatment suitable for disease.
Fig. 6 shows a kind of structural representation of multiple database interactive device based on wide in range retrieval provided in this embodiment
Figure, described device include: retrieval request receiving module 601, wide in range property retrieval module 602 and Evidence grade judgment module 603,
In:
The retrieval request receiving module 601, for receiving the retrieval request of searching terminal, the retrieval request includes inspection
Rope keyword；
The wide in range property retrieval module 602 is more for being interpreted according to the retrieval request and disease gene variation and drug
Database interaction system interacts, and is made a variation according to the search key in the disease gene and drug interprets most evidences
Wide in range property retrieval is carried out in each database of library interactive system, and each database disease gene is obtained according to the result of retrieval and is made a variation
Evidence grade relevant to drug；
Evidence grade is greater than default by the Evidence grade judgment module 603 if being greater than preset value for Evidence grade
The database of value is determined as target database, and the search result of target database is fed back to interpretation reporting device and is solved
It reads；
Wherein, it includes genetic mutation that the disease gene variation and drug, which interpret each database of multiple database interactive system,
With disease information database, medication data library and disease and variation documentation & info database；The genetic mutation and disease
Sick information database is for storing genetic mutation and the relevant data of disease information；The medication data library is for storing medicine
The treatment-related data of object；The disease is to variation documentation & info database for storing disease number relevant with variation document
According to.
Specifically, the retrieval request receiving module 601 is used to receive the retrieval request of searching terminal, the retrieval request
Including search key；The wide in range property retrieval module 602 is used for according to the retrieval request and disease gene makes a variation and drug
Interpret multiple database interactive system interact, and according to the search key the disease gene make a variation and drug interpretation
Wide in range property retrieval is carried out in each database of multiple database interactive system, and each database disease base is obtained according to the result of retrieval
Because of the Evidence grade relevant to drug that makes a variation；If the Evidence grade judgment module 603 is greater than preset value for Evidence grade,
The database that Evidence grade is greater than preset value is determined as target database, and the search result of target database is fed back into solution
Reporting device is read to be interpreted.
The present embodiment is by establishing by genetic mutation and disease information database, medication data library and disease and change
The multiple database interactive system that different article offers information database composition interacts formula retrieval, and retrieving is simple, and can obtain
More acurrate and comprehensive search result.
Further, on the basis of above-mentioned apparatus embodiment, described device further include:
Read through model is solved, is interpreted for the search result to target database, generates and interprets report.
Further, on the basis of above-mentioned apparatus embodiment, described device further include:
Statistical module, for counting the disease gene retrieved in each target database variation evidence relevant to drug etc.
Grade, counts the height of each Evidence grade, the result of statistics is sent to the interpretation reporting device, and receives the interpretation report
The interpretation report that device is sent.
Multiple database interactive device described in the present embodiment based on wide in range retrieval can be used for executing above method implementation
Example, principle is similar with technical effect, and details are not described herein again.
Referring to Fig. 7, the electronic equipment, comprising: processor (processor) 701, memory (memory) 702 and total
Line 703；
Wherein,
The processor 701 and memory 702 complete mutual communication by the bus 703；
The processor 701 is used to call the program instruction in the memory 702, to execute above-mentioned each method embodiment
Provided method.
The present embodiment discloses a kind of computer program product, and the computer program product includes being stored in non-transient calculating
Computer program on machine readable storage medium storing program for executing, the computer program include program instruction, when described program instruction is calculated
When machine executes, computer is able to carry out method provided by above-mentioned each method embodiment.
The present embodiment provides a kind of non-transient computer readable storage medium, the non-transient computer readable storage medium
Computer instruction is stored, the computer instruction makes the computer execute method provided by above-mentioned each method embodiment.
The apparatus embodiments described above are merely exemplary, wherein described, unit can as illustrated by the separation member
It is physically separated with being or may not be, component shown as a unit may or may not be physics list
Member, it can it is in one place, or may be distributed over multiple network units.It can be selected according to the actual needs
In some or all of the modules achieve the purpose of the solution of this embodiment.Those of ordinary skill in the art are not paying creativeness
Labour in the case where, it can understand and implement.
Through the above description of the embodiments, those skilled in the art can be understood that each embodiment can
It realizes by means of software and necessary general hardware platform, naturally it is also possible to pass through hardware.Based on this understanding, on
Stating technical solution, substantially the part that contributes to existing technology can be embodied in the form of software products in other words, should
Computer software product may be stored in a computer readable storage medium, such as ROM/RAM, magnetic disk, CD, including several fingers
It enables and using so that a computer equipment (can be personal computer, server or the network equipment etc.) executes each implementation
Method described in certain parts of example or embodiment.
It is noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although reference
Invention is explained in detail for previous embodiment, those skilled in the art should understand that: it still can be right
Technical solution documented by foregoing embodiments is modified or equivalent replacement of some of the technical features；And this
It modifies or replaces, the spirit and model of technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution
It encloses.
Claims (8)
1. a kind of multiple database exchange method based on wide in range retrieval characterized by comprising
The retrieval request of searching terminal is received, the retrieval request includes search key；
It is made a variation according to the retrieval request with disease gene and drug is interpreted multiple database interactive system and interacted, and according to institute
State search key the disease gene make a variation and drug interpret multiple database interactive system each database in carry out it is wide in range
Property retrieval, each database disease gene is obtained according to the result of retrieval and is made a variation Evidence grade relevant to drug；
Each database disease gene variation search result relevant to drug is scored according to the score value of correspondence database,
And each data score is fed back into interpretation reporting device and is interpreted；
Wherein, it includes genetic mutation and disease that the disease gene variation and drug, which interpret each database of multiple database interactive system,
Sick information database, medication data library and disease and variation documentation & info database；The genetic mutation and disease letter
Breath database is for storing genetic mutation and the relevant data of disease information；It is controlled for storing drug in the medication data library
Treat relevant data；The disease is to variation documentation & info database for storing disease data relevant with variation document.
2. the method according to claim 1, wherein the method also includes:
The interpretation reporting device interprets the search result of target database, generates and interprets report.
3. according to the method described in claim 2, it is characterized in that, the method also includes:
It interprets result statistic device and counts the disease gene variation Evidence grade relevant to drug retrieved in each target database
Height, the result of statistics is sent to the interpretation reporting device, and receive it is described interpretation reporting device send solution read the newspaper
It accuses.
4. a kind of multiple database interactive device based on wide in range retrieval characterized by comprising
Retrieval request receiving module, for receiving the retrieval request of searching terminal, the retrieval request includes search key；
Wide in range property retrieval module interacts system for interpreting multiple database with disease gene variation and drug according to the retrieval request
System interacts, and is made a variation according to the search key in the disease gene and drug interprets multiple database interactive system
Wide in range property retrieval is carried out in each database, it is relevant to drug to obtain each database disease gene variation according to the result of retrieval
Evidence grade；
Evidence grade judgment module, for each database disease gene to be made a variation search result relevant to drug according to correspondence
The score value of database scores, and each data score is fed back to interpretation reporting device and is interpreted；
Wherein, it includes genetic mutation and disease that the disease gene variation and drug, which interpret each database of multiple database interactive system,
Sick information database, medication data library and disease and variation documentation & info database；The genetic mutation and disease letter
Breath database is for storing genetic mutation and the relevant data of disease information；It is controlled for storing drug in the medication data library
Treat relevant data；The disease is to variation documentation & info database for storing disease data relevant with variation document.
5. device according to claim 4, which is characterized in that described device further include:
Read through model is solved, is interpreted for the search result to target database, generates and interprets report.
6. device according to claim 5, which is characterized in that described device further include:
Statistical module, for counting the disease gene retrieved in each target database variation Evidence grade relevant to drug, system
The result of statistics is sent to the interpretation reporting device, and receives the interpretation reporting device by the height for counting each Evidence grade
The interpretation of transmission is reported.
7. a kind of electronic equipment characterized by comprising
At least one processor；And
At least one processor being connect with the processor communication, in which:
The memory is stored with the program instruction that can be executed by the processor, and the processor calls described program to instruct energy
Enough methods executed as described in claims 1 to 3 is any.
8. a kind of non-transient computer readable storage medium, which is characterized in that the non-transient computer readable storage medium is deposited
Computer program is stored up, the computer program makes the computer execute the method as described in claims 1 to 3 is any.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110415771A (en) * | 2019-07-16 | 2019-11-05 | 江苏省食品药品监督检验研究院 | A kind of compound Information in Mass Spectra bulk retrieval method based on R language |
| CN114334078A (en) * | 2022-03-14 | 2022-04-12 | 至本医疗科技（上海）有限公司 | Method, electronic device, and computer storage medium for recommending medication |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140199273A1 (en) * | 2011-08-05 | 2014-07-17 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
| CN105701365A (en) * | 2016-01-12 | 2016-06-22 | 西安电子科技大学 | Cancer-related genes finding method by using miRNA expression data |
| CN107437004A (en) * | 2017-08-07 | 2017-12-05 | 深圳华大基因研究院 | A kind of system intelligently understood for tumour individuation genetic test |
-
2018
- 2018-06-29 CN CN201810699317.7A patent/CN109065181B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140199273A1 (en) * | 2011-08-05 | 2014-07-17 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
| CN105701365A (en) * | 2016-01-12 | 2016-06-22 | 西安电子科技大学 | Cancer-related genes finding method by using miRNA expression data |
| CN107437004A (en) * | 2017-08-07 | 2017-12-05 | 深圳华大基因研究院 | A kind of system intelligently understood for tumour individuation genetic test |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110415771A (en) * | 2019-07-16 | 2019-11-05 | 江苏省食品药品监督检验研究院 | A kind of compound Information in Mass Spectra bulk retrieval method based on R language |
| CN110415771B (en) * | 2019-07-16 | 2022-11-29 | 江苏省食品药品监督检验研究院 | Compound mass spectrum information batch retrieval method based on R language |
| CN114334078A (en) * | 2022-03-14 | 2022-04-12 | 至本医疗科技（上海）有限公司 | Method, electronic device, and computer storage medium for recommending medication |
| CN114334078B (en) * | 2022-03-14 | 2022-06-14 | 至本医疗科技（上海）有限公司 | Method, electronic device, and computer storage medium for recommending medication |
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