CN109010049B

CN109010049B - Method for preparing sulfasalazine tablets

Info

Publication number: CN109010049B
Application number: CN201810648365.3A
Authority: CN
Inventors: 肖祖华; 江尔胜
Original assignee: Suzhou Huanghe Pharmaceutical Co ltd
Current assignee: Suzhou Huanghe Pharmaceutical Co ltd
Priority date: 2018-06-22
Filing date: 2018-06-22
Publication date: 2021-03-02
Anticipated expiration: 2038-06-22
Also published as: CN109010049A

Abstract

The invention relates to a method for preparing a sulfasalazine tablet, which uses a tablet preparation die, wherein the tablet preparation die comprises an upper die, a lower die and a limiting piece; the upper die is provided with a penetrating film making cavity, the lower die is provided with film making top pillars, and the film making top pillars are respectively inserted into the film making cavity in a fitting manner; the limiting piece comprises a limiting strip, and the top end surface of the limiting strip and the bottom end surface of the limiting strip respectively support the upper die and the lower die; the preparation method comprises the following steps of mixing sulfasalazine powder and water, stirring, and preparing sulfasalazine ointment; coating the sulfasalazine ointment on a tabletting mold to obtain the tabletting mold coated with the sulfasalazine ointment; drying the tabletting mold coated with the sulfasalazine ointment to obtain a tabletting mold filled with sulfasalazine tablets; and (4) enabling the upper die to be close to the lower die to enable the tabletting top column to eject the sulfasalazine tablets out, so as to obtain the sulfasalazine tablets. The method for preparing the salazosulfapyridine tablet has simple procedures, and is favorable for reducing the cost; can ensure the stable weight of the sulfasalazine tablet.

Description

Method for preparing sulfasalazine tablets

Technical Field

The invention relates to the technical field of sulfasalazine production, and particularly relates to a sulfasalazine tabletting mold, a corresponding sulfasalazine tabletting device and a corresponding sulfasalazine tabletting method.

Background

The traditional production of salazosulfapyridine is carried out,

crushing (the crushing is an operation process of pulverizing solid materials by mechanical force),

Screening (the screening is the operation of separating the mixed materials with different granularities according to the granularity),

Mixing (mixing is the operation of uniformly mixing more than two components)

Granulating (granulation is an operation of processing the materials in the state of powder, molten liquid, aqueous solution, etc. into granules with a certain shape and size),

Drying (drying is an operation in which moisture in the material is vaporized by heat energy and the vaporized moisture is taken away by air flow or vacuum to obtain a dried product),

Granulating and mixing (granulating dry granules into granules with uniform size and easy flow by granulating equipment),

Tabletting (tabletting is the process of pressing materials and proper auxiliary materials into a tablet preparation by using a tabletting machine), and other procedures, wherein each procedure needs to be equipped with special equipment, so that the traditional production equipment of salazosulfapyridine is high in price, and the cost is not reduced.

Disclosure of Invention

In order to solve the above problems, an object of the present invention is to provide a sulfasalazine tableting mold which has a simple structure, facilitates tableting of sulfasalazine, and can be recycled.

The invention relates to a sulfasalazine tabletting mold, which adopts the detailed technical scheme that: the sulfasalazine tabletting mold comprises a tabletting mold, wherein the tabletting mold comprises an upper mold, a lower mold and a limiting piece; the upper die is provided with a penetrating film making cavity, the lower die is provided with film making top pillars, and the film making top pillars are respectively inserted into the film making cavity in a fitting manner; the limiting part comprises a limiting strip, and the top end surface of the limiting strip and the bottom end surface of the limiting strip respectively support the upper die and the lower die.

Further, the lower mould still includes piece and the lower mould bottom plate that generates heat, generate heat the piece be provided with generate heat piece electric connection's wiring ear, the lower mould is provided with the chamber that generates heat, generate heat the piece embedding generate heat the chamber, the lower mould bottom plate cover generate heat the chamber and with lower mould fixed connection, the wiring ear passes the lower mould and exposes.

The lug is connected with the power supply, so that the heating sheet can be directly heated to dry the sulfasalazine ointment, the cost can be reduced, and the operation is convenient.

Further, the film-making mould still includes the retaining member, and the retaining member is provided with the locking post with downwardly extending, and the front end of going up the mould, the front end of lower mould all are provided with the locating part front end sunken, and the rear end of spacing strip all is provided with the locking hole that runs through, and locating part front end piece supports and holds the locating part front end sunken, and the retaining member supports the rear end of holding the mould, and the locking post passes the locking hole with laminating respectively.

The retaining member can make the position of keeping between locating part and the film-making mould, can guarantee the weight stability of sulfasalazine tablet.

Furthermore, a locking projection is arranged on the locking column.

The locking firmness of the locking member can be improved.

Furthermore, two sides of the upper die are provided with thickness limiting frames in an upward extending manner, and the thickness of each thickness limiting frame is the thickness A of each thickness limiting frame; the thickness A of the thickness limiting frame is 0.1-0.3 mm.

When the sulfasalazine ointment is coated on the upper die, the thickness limiting frame A is convenient for controlling the thickness of the sulfasalazine ointment, and the weight stability of the sulfasalazine tablet can be ensured.

The sheet-making die further comprises a connecting piece provided with a limiting boss, the upper die is provided with a connecting hole, the lower die is provided with a penetrating limiting through hole, and the bottom end of the limiting through hole is provided with a limiting counter bore; the connecting holes are coaxial with the limiting through holes respectively, the connecting piece penetrates through the limiting through holes to be inserted into the connecting holes and fixed, and the limiting boss abuts against the inner wall of the limiting counter bore.

Can prevent that the film-making fore-set from taking out completely in the film-making chamber, improve the reliability of film-making mould.

Furthermore, the limiting part comprises two or more limiting strips parallel to each other and a limiting part front end block, and one end of each limiting strip is fixedly connected with the limiting part front end block.

The upper die and the lower die can be stressed uniformly, each limiting strip can be abutted to the upper die and the lower die through one-time operation, the efficiency can be improved, and the operation is more convenient.

Further, the front end of the upper die is provided with a coating inclined plane.

The scraper can be prevented from being broken due to the fact that the scraper abuts against the front end of the sheet making die.

Compared with the prior art, the sulfasalazine tablet preparation mold has the following beneficial effects: 1. the structure is simple, the sulfasalazine tablet is convenient to prepare, and the sulfasalazine can be recycled; 2. the lug is connected with a power supply, so that the heating sheet can be directly heated to dry the sulfasalazine ointment, the cost can be reduced, and the operation is convenient; 3. can ensure the stable weight of the sulfasalazine tablet.

In order to solve the problems, the invention aims to provide a sulfasalazine tabletting device which is simple in structure and beneficial to reducing the cost.

The invention relates to a sulfasalazine tabletting mold, which adopts the detailed technical scheme that: the sulfasalazine tabletting mold comprises a tabletting mold, wherein the tabletting mold comprises an upper mold, a lower mold and a limiting piece; the upper die is provided with a penetrating film making cavity, the lower die is provided with film making top pillars, and the film making top pillars are respectively inserted into the film making cavity in a fitting manner; the limiting part comprises a limiting strip, the top end surface of the limiting strip and the bottom end surface of the limiting strip respectively support the upper die and the lower die, and the sheet making device comprises a conveying part; the conveying part comprises a conveying device; the sheet-making device also comprises a coating machine fixedly arranged above the conveying device, and the sheet-making dies are arranged on the conveying device.

Further, the tabletting device also comprises a quantifying part; the quantitative part comprises a scraper arranged above the conveying device, and the bottom end of the scraper is less than or equal to the thickness of the sheet making die.

A small amount of sulfasalazine ointment on the upper end surface of the upper die can be removed, so that the weight stability of the sulfasalazine tablet can be ensured.

Furthermore, the quantitative part also comprises a rotatable press roller arranged above the conveying device, the press roller is positioned in front of the scraper, and the bottom end of the press roller is less than or equal to the thickness of the sheet making die.

The compression roller is used for continuously compressing the sulfasalazine ointment in the thickness limiting frame, so that the uniformity of the sulfasalazine ointment in the tabletting mold is improved, and the weight stability of the sulfasalazine tablet can be ensured.

Further, ration portion is still including setting up the adsorption tank of conveyor top, and the adsorption tank is just to the bottom of scraper, and the adsorption tank is provided with the output tube.

The adsorption tank can suck a small amount of sulfasalazine ointment shoveled by the scraper away, so that the sulfasalazine ointment is prevented from being accumulated on the scraper or the tabletting mold.

The lower die further comprises a heating sheet and a lower die bottom plate, the heating sheet is provided with a wiring lug electrically connected with the heating sheet, the lower die is provided with a heating cavity, the heating sheet is embedded into the heating cavity, the lower die bottom plate covers the heating cavity and is fixedly connected with the lower die, the wiring lug penetrates through the lower die to be exposed, and the sheet making device further comprises a sheet making and drying device; the sheet-making drying device is provided with an accommodating cavity; the accommodating cavity is matched with the sheet making die; the containing cavity is internally provided with a wiring terminal in an upward extending mode, and the wiring terminal is respectively matched with the wiring lugs.

The film-making mould filled with the sulfasalazine ointment is inserted into the containing cavity, so that the heating sheet is connected with a power supply and generates heat conveniently.

Furthermore, arc-shaped elastic pieces uniformly distributed around the axis of the wiring terminal are fixedly arranged at the top of the wiring terminal, and the outer diameter of a circumscribed circle of each arc-shaped elastic piece is larger than the inner diameter of a hole of each wiring lug.

The arc-shaped elastic sheet is tightly attached to the inner wall of the hole of the wiring lug, so that the electrical connection between the wiring terminal and the wiring lug is reliable.

Furthermore, the front wall of the accommodating cavity and the rear wall of the accommodating cavity are respectively a front end side wall and a rear end side wall, the rear end side wall extends inwards to form a rear end inner wall, and the rear end inner wall is provided with a wiring port; binding post horizontal extension forms the linkage segment, and the linkage segment cover is equipped with conductive sleeve, and conductive sleeve imbeds rear end inner wall and fixes, and the linkage segment is worn out from the lateral wall of wiring mouth, and front end lateral wall is provided with takes out the cambered surface.

When taking out the film making mould from the film making drying device, the film making mould can be held or clamped at the wiring port, then the film making drying device is taken out by rotating the film making drying device, and the film making mould can be taken out by hands or a mechanical arm conveniently.

Further, the film making device also comprises guide rails arranged on two sides of the conveying device, and the horizontal distance between the guide rails is adjustable.

Compared with the prior art, the sulfasalazine tabletting device has the following beneficial effects: 1. the structure is simple, and the cost is reduced; 2. the weight stability of the sulfasalazine tablet can be ensured; 3. when taking out the film making mould from the film making drying device, the film making mould can be held or clamped at the wiring port, then the film making drying device is taken out by rotating the film making drying device, and the film making mould can be taken out by hands or a mechanical arm conveniently.

In order to solve the problems, the invention aims to provide a method for preparing a sulfasalazine tablet, which has simple process and is beneficial to reducing the cost.

The method for preparing the salazosulfapyridine tablet adopts the detailed technical scheme that: the method for preparing the sulfasalazine tablet uses a tablet preparation die which comprises an upper die, a lower die and a limiting piece; the upper die is provided with a penetrating film making cavity, the lower die is provided with film making top pillars, and the film making top pillars are respectively inserted into the film making cavity in a fitting manner; the limiting piece comprises a limiting strip, and the top end surface of the limiting strip and the bottom end surface of the limiting strip respectively support the upper die and the lower die; which comprises the following steps of,

s1, mixing sulfasalazine powder and water, stirring, and making into sulfasalazine ointment;

s2, coating the sulfasalazine ointment on a film-making mold to obtain a film-making mold coated with the sulfasalazine ointment 3;

s3, drying the tabletting mold coated with the sulfasalazine ointment to obtain a tabletting mold filled with sulfasalazine tablets;

and S4, approaching the upper die to the lower die to enable the tabletting top column to eject the sulfasalazine tablet, thereby obtaining the sulfasalazine tablet.

Further, in S2, the method further includes a step S21 of pressing the sheeting die 1 coated with the sulfasalazine ointment 3.

The weight stability of the salazosulfapyridine tablet 31 can be ensured.

Further, after S21, the method includes a step S22 of applying paste to the tip of the sheet mold.

The weight stability of the salazosulfapyridine tablet 31 can be ensured.

Further, after S4, S5 is included, and the tableting cavity and tableting top column are cleaned.

And further, after the high-pressure water washing flaking cavity and the flaking ejection column are adopted, the flaking cavity and the flaking ejection column are blown dry by compressed air.

Compared with the prior art, the method for preparing the salazosulfapyridine tablet has the following beneficial effects: 1. the process is simple, and the cost is reduced; 2. can ensure the stable weight of the sulfasalazine tablet.

Drawings

Fig. 1 is a perspective view of a sheeting die 1.

Fig. 2 is a perspective exploded view of the sheet mold 1.

Fig. 3 is a perspective view of the upper mold 11.

Fig. 4 is a perspective view of the lower mold 12.

Fig. 5 is a perspective view of the stopper 13.

Fig. 6 is a perspective view of retaining member 14.

Fig. 7 is a schematic plan view of the tableting die 1 of the present invention.

Fig. 8 is a schematic view of the section i-i of fig. 7. In fig. 8, the tablet mold 1 is in a tablet state, and the salazosulfapyridine ointment 3 is shown by the unordered dot filling.

Fig. 9 is a schematic view of the section i-i of fig. 7. In fig. 9, the tablet-making mold 1 is in a mold-released state, regular dot-filling indicates the sulfasalazine tablet 31, and a thick solid arrow indicates the moving direction of the lower mold 12; the thick dotted arrow indicates the falling direction of the sulfasalazine tablet 31.

Fig. 10 is a schematic perspective view of the tableting device 2.

Fig. 11 is a half-sectional schematic view of the tableting device 2.

Fig. 12 is an enlarged schematic view at ii of fig. 11. In fig. 12, thick solid line arrows indicate the moving direction of the sheet forming die 1, and thick broken line arrows indicate the direction of air flow due to negative pressure.

Fig. 13 is a schematic perspective exploded view of the tablet drying device 24.

Fig. 14 is a schematic cross-sectional view at iii of fig. 13 [ cut along a plane where the axis of the connecting terminal 242 is located ].

Fig. 15 is a schematic half-sectional view of the pellet drying apparatus 24. In fig. 15, the thick solid arrow indicates the direction of rotation of one end of the sheet mold 1 when the sheet mold 1 is taken out; the dotted arrow indicates the direction of rotation of the terminal 242 when the sheet mold 1 is removed.

FIG. 16 is a schematic flow chart of a process for tableting sulfasalazine.

A sheet making mold 1; an upper die 11; a tableting chamber 111; a coating bevel 112; a connection hole 113; a lower die 12; a tableting jack post 121; a heat generating sheet 123; a lug 1231; a heat generating chamber 1232; a lower die base plate 1233; a limiting through hole 124; a limit counter bore 1241; a stopper 13; a spacing bar 131; a limiter front block 132; a stopper front end recess 133; recessed guide surfaces 1331; a locking aperture 134; a retaining member 14; a locking post 141; a locking projection 142; a connecting member 15; a limit boss 151; a thickness limit frame 16; the thickness of the thickness limiting frame is A; a sheet making device 2; a conveying section 21; the conveying device 211; a frame 212; a mounting plate 213; a coater 22; a quantitative section 23; a scraper 231; a scraper mounting bar 2311; a press roll 232; a pressure adjustment knob 2321; an adsorption tank 233; an output pipe 2331; a tabletting and drying device 24; a housing cavity 241; a connection terminal 242; an arc-shaped elastic sheet 2421; a tip cap 2422; a bottom end ring 2423; a connecting section 2424; a conductive sleeve 2425; a front end side wall 243; taking out the cambered surface 2431; a rear end side wall 244; a rear inner wall 245; a wiring port 2451; the insertion guide surface 246; a guide rail 25; sulfasalazine ointment 3; sulfasalazine tablet 31.

Detailed Description

The technical scheme of the invention is explained in the following by combining the attached drawings of the invention.

In the first embodiment, the present invention is a sulfasalazine tableting mold.

Referring to fig. 1-9, the sulfasalazine tablet making mold of the present embodiment includes a tablet making mold 1, and the tablet making mold 1 includes an upper mold 11, a lower mold 12 and a limiting member 13.

The upper die 11 is provided with a through film making cavity 111, the lower die 12 is provided with a film making jack post 121, and the film making jack posts 121 are respectively inserted into the film making cavity 111 in a fitting manner. Generally, the cross-section of the slice cavity 111 and the cross-section of the slice top column 121 are the same and are both circular, and the cross-section of the slice cavity 111 and the cross-section of the slice top column 121 can be designed into other shapes as needed, for example, the cross-section of the slice cavity 111 and the cross-section of the slice top column 121 are both square, triangular, etc. Generally, the upper mold 11 and the lower mold 12 are made of medical stainless steel or medical ABS.

The limiting member 13 includes a limiting bar 131, and the top end surface of the limiting bar 131 and the bottom end surface of the limiting bar 131 respectively support against the upper die 11 and the lower die 12. Generally, the limiting member 13 includes two or more limiting bars 131 parallel to each other and a limiting member front end block 132, and one end of each limiting bar 131 is fixedly connected with the limiting member front end block 132; the upper die 11 and the lower die 12 can be stressed uniformly, and the limiting strips 131 can be abutted against the upper die 11 and the lower die 12 by one-time operation, so that the efficiency can be improved, and the operation is more convenient.

The working principle of the sulfasalazine tableting mold is as follows: before use, filling the sulfasalazine ointment 3 into a space surrounded by the tabletting cavity 111 and the tabletting top column 121; then, the tablet forming die 1 and the sulfasalazine ointment 3 are heated and dried, so that the sulfasalazine ointment 3 is dried and hardened to form the sulfasalazine tablet 31. At this time, the tablet mold 1 is in a tablet state.

When the mold is to be removed, the stopper 13 is pulled out from between the upper mold 11 and the lower mold 12, the lower mold 12 is pushed, and the tableting jack 121 ejects the sulfasalazine tablet 31 from the tableting cavity 111, so that the sulfasalazine tablet 31 can be collected for the next process, such as bottling and the like. At this time, the sheet-making mold 1 is in a mold-released state.

Reset locating part 13 and make film-making mould 1 resume to the film-making state and keep, can wash film-making chamber 111 and film-making fore-set 121 [ usually adopt high-pressure water to wash and adopt compressed air to weather ] back, film-making mould 1 can follow recycling.

The lower die 12 further comprises a heating sheet 123 and a lower die bottom plate 1233, the heating sheet 123 is provided with a wire connecting lug 1231 electrically connected with the heating sheet 123, the lower die 12 is provided with a heating cavity 1232, the heating sheet 123 is embedded into the heating cavity 1232, the lower die bottom plate 1233 covers the heating cavity 1232 and is fixedly connected with the lower die 12 (i.e., glue is bonded or a fastener is connected), and the wire connecting lug 1231 penetrates through the lower die 12 to be exposed. Generally, the lower mold 12 is made of medical stainless steel, and the heat generating sheet 123 is a PTC heater. The wire connecting lug 1231 is connected with a power supply, so that the heating sheet 123 can be directly heated to dry the sulfasalazine ointment 3, the sheet making die 1 does not need to be placed into drying equipment such as a hot air dryer, the cost can be reduced, and the operation is convenient.

The sheet making die 1 further comprises a locking member 14, the locking member 14 is provided with a locking column 141 in a downward extending manner, the front end of the upper die 11 and the front end of the lower die 12 are both provided with a limiting member front end depression 133, the rear end of the limiting strip 131 is both provided with a through locking hole 134, the limiting member front end block 132 abuts against the limiting member front end depression 133, the locking member 14 abuts against the rear end of the upper die 11, and the locking column 141 respectively passes through the locking hole 134 in a fitting manner. The locking member 14 can keep the position (namely locked) between the limiting member 13 and the tabletting mold 1, so that the limiting member 13 is prevented from slipping out from the upper mold 11 and the lower mold 12 due to vibration and other reasons in the production process, the upper mold 11 and the lower mold 12 can approach each other in the production process, and the amount of the sulfasalazine ointment 3 in the tabletting cavity 111 is reduced, thereby ensuring the stable weight of the sulfasalazine tablet 31. In general, the locking post 141 is provided with a locking protrusion 142 (a protrusion having a semicircular cross section, which is generally made of PP plastic), so that the locking post 141 is difficult to be drawn out from the locking hole 134, and the locking firmness of the locking member 14 can be improved.

Two sides of the upper die 11 are provided with thickness limiting frames 16 in an upward extending manner, and the thickness of each thickness limiting frame 16 is the thickness A of each thickness limiting frame; the thickness A of the thickness limiting frame is 0.1-0.3 mm. When the sulfasalazine ointment 3 is coated on the upper die 11 (coated by a coating machine), the thickness limit frame thickness a facilitates the control of the thickness of the sulfasalazine ointment 3 [ the coating can be carried out on the basis that the top end of the thickness limit frame 16 is exposed and scraped by the coating machine and the like ], so that the weight stability of the sulfasalazine tablet 31 can be ensured.

The sheet making die 1 further comprises a connecting piece 15 provided with a limiting boss 151, the upper die 11 is provided with a connecting hole 113, the lower die 12 is provided with a penetrating limiting through hole 124, and the bottom end of the limiting through hole 124 is provided with a limiting counter bore 1241; the connecting holes 113 are coaxial with the limiting through holes 124, the connecting piece 15 penetrates through the limiting through holes 124 to be inserted into the connecting holes 113 and fixed (usually fixed through threaded connection), and the limiting boss 151 abuts against the inner wall of the limiting counter bore 1241. The tablet ejection columns 121 can be prevented from being completely withdrawn from the tablet making cavities 111, resulting in separation of the upper and lower dies 11 and 12, and the need to reassemble the upper and lower dies 11 and 12 can be avoided, so that the reliability of the tablet making die 1 can be improved.

Generally, the front end of the upper die 11 is provided with a coating slope 112. The scraper 231 can be prevented from being broken by abutting the scraper 231 against the front end of the sheet-making die 1.

In the second embodiment, the present invention is an apparatus for preparing sulfasalazine.

Referring to fig. 10 to fig. 15, the sulfasalazine tableting device of the present embodiment includes a tableting device 2, where the tableting device 2 includes a conveying portion 21; the conveying section 21 includes a conveying device 211. The conveying device 211 is typically a power belt, and may be a linear conveying device such as a power chain or a power chain plate. Typically, the conveying part 21 further includes a frame 212, and the frame 212 is fixedly connected to the conveying device 211 and is used for supporting the conveying device 211.

The sheet-making device 2 further includes a coater 22 fixedly disposed above the conveying device 211. Typically, the coater 22 is a conventional roll coater [ the details of the coater 22 are shown in the drawings ], such as a DCM-36 coater from the automation equipment limited, tokyo, south-front, although other manufacturers or specifications are also possible. Generally, the coater 22 has a pressure adjusting function and a paste amount adjusting function.

The operating principle of the sulfasalazine tableting device is as follows: before use, the sulfasalazine ointment 3 is put into the ointment bucket of the coating machine 22, and the sulfasalazine ointment 3 can be put into the ointment bucket of the coating machine 22 while being used in continuous production.

When the device is used, a plurality of slicing molds 1 are sequentially arranged on the conveying device 211, the conveying device 211 and the coating machine 22 are started, the conveying device 211 conveys the slicing molds 1, the sulfasalazine ointment 3 is filled in a space formed by the sulfasalazine ointment 3 and the space surrounded by the slicing cavity 111 and the slicing top column 121 after the sulfasalazine ointment passes through the coating machine 22. The sulfasalazine ointment 3 is not arranged between the sequentially arranged film-making moulds 1, so that the sulfasalazine ointment 3 can be saved, and the cost is reduced.

The sheet making device 2 further includes a quantifying section 23; the quantitative section 23 includes a scraper 231 disposed above the conveying device 211, and a height of a bottom end of the scraper 231 [ a distance from the bottom end of the scraper 231 to a top end face of the conveying device 211 ] is less than or equal to a thickness of the sheeting die 1. Typically, the scraper 231 is made of an elastic material [ such as spring steel, etc. ].

The small amount of the sulfasalazine ointment 3 on the upper end surface of the upper die 11 can be eradicated, so that the small amount of the sulfasalazine ointment 3 on the upper end surface of the upper die 11 is prevented from being adhered to the sulfasalazine tablet 31 during demolding, and the stable weight of the sulfasalazine tablet 31 can be ensured.

The quantitative section 23 further comprises a rotatable pressure roller 232 disposed above the conveying device 211, the pressure roller 232 is located in front of the scraper 231, and the bottom height of the pressure roller 232 [ the distance from the lowest point of the pressure roller 232 to the top end surface of the conveying device 211 ] is less than or equal to the thickness of the sheeting die 1. The pressing roller 232 continuously presses the sulfasalazine ointment 3 in the thickness limiting frame 16, so that the uniformity of the sulfasalazine ointment 3 in the tablet forming die 1 is improved (the uniformity along the moving direction of the conveying device 211), and the weight stability of the sulfasalazine tablet 31 can be ensured.

The quantitative section 23 further includes an adsorption tank 233 provided above the conveyor 211, the adsorption tank 233 facing the bottom end of the scraper 231, and the adsorption tank 233 is provided with an output pipe 2331. Typically, the outlet pipe 2331 is in communication with a source of negative pressure, such as a suction fan or the like.

The adsorption groove 233 can suck a small amount of the sulfasalazine ointment 3 scooped by the scraper 231, and prevent the sulfasalazine ointment 3 from accumulating on the scraper 231 or the sheeting die 1.

Typically, the conveying section 21 further includes mounting plates 213 fixedly provided on both sides of the conveying device 211. The mounting plate 213 is used to mount the scraper 231, for example, by a scraper mounting bar 2311 to mount the scraper 231. The mounting plate 213 is also used to mount the pressure roller 232, for example, the pressure roller 232 is mounted through the central axis of the pressure roller 232, and the mounting plate 213 is provided with a pressure adjusting knob 2321 abutting against the central axis of the pressure roller 232 to adjust the pressure of the pressure roller 232. The mounting plate 213 is also used to mount the suction groove 233, such as by welding or fastening.

Typically, the flaking device 2 further comprises guide rails 25 arranged on both sides of the conveying device 211, the horizontal distance between the guide rails 25 being adjustable [ i.e. the horizontal distance between the guide rails 25 when looking down on the conveying device 211 ] [ typically being adjustable by twisting a knob ].

The tabletting device 2 further comprises a tabletting and drying device 24; the tablet drying device 24 is provided with an accommodating chamber 241; the accommodating cavity 241 and the film-making mold 1 are matched with each other (namely projection of the accommodating cavity 241 on a horizontal plane, projection of the film-making mold 1 on the horizontal plane, and superposition of the two); the accommodating cavity 241 is provided with a connecting terminal 242 extending upward, and the connecting terminal 242 is respectively matched with the connecting lug 1231 (that is, the axis of the connecting terminal 242 coincides with the axis of the hole of the connecting lug 1231). Typically, the terminals 242 are electrically connected to a power source, such as mains electricity or a battery. The sheet making die 1 filled with the sulfasalazine ointment 3 is inserted into the accommodating cavity 241 [ usually, the sheet making die 1 passes through the quantifying part 23 and then is output from the output end of the conveying device 211, and a manipulator or a worker inserts the sheet making die 1 into the accommodating cavity 241 ], so that the heating sheet 123 can be connected with a power supply to generate heat, and the operation is convenient. The slide drying device 24 is generally disposed behind the conveying device 211.

Arc-shaped elastic sheets 2421 uniformly distributed around the axis of the wiring terminal 242 are fixedly arranged at the top of the wiring terminal 242, and when the circumscribed circle of the arc-shaped elastic sheets 2421 is viewed from top, the outer diameter of the circumscribed circle of the arc-shaped elastic sheets 2421 is larger than the inner diameter of the hole of the wiring lug 1231. The arc-shaped spring 2421 is typically made of copper sheet and is fixedly disposed on the top of the terminal 242 by a top end cap 2422 and a bottom end ring 2423 disposed on the top of the terminal 242. The arc-shaped elastic sheet 2421 is tightly attached to the inner wall of the hole of the wire connection lug 1231, so that the electrical connection between the wire connection terminal 242 and the wire connection lug 1231 is reliable.

The front wall of the accommodating cavity 241 and the rear wall of the accommodating cavity 241 are respectively a front end side wall 243 and a rear end side wall 244, the rear end side wall 244 extends inwards to form a rear end inner wall 245, and the rear end inner wall 245 is provided with a wiring port 2451; the wire connecting terminal 242 horizontally extends to form a connecting section 2424, the connecting section 2424 is sleeved with a conductive sleeve 2425, the conductive sleeve 2425 is embedded into the rear end inner wall 245 and fixed, the connecting section 2424 penetrates out of the side wall of the wire connecting opening 2451, and the front end side wall 243 is provided with a taking-out cambered surface 2431. Usually, the inner wall of the conductive sleeve 2425 is provided with a carbon brush (not shown in the drawings) and is electrically connected to the commercial power or the battery, so that the connection section 2424 can rotate around the axis of the conductive sleeve 2425 and keep the electrical connection. When the film-making mold 1 is taken out from the film-making drying device 24, the film-making mold 1 can be held or clamped at the wiring opening 2451, and then the film-making drying device 24 is rotated to take out the film-making drying device 24, so that a user or a mechanical hand can take out the film-making mold 1 conveniently.

The top end of the side wall of the accommodating chamber 241 is provided with a putting guide surface 246 to perform a guiding function.

Example three, this example is a method for preparing sulfasalazine tablets.

The method for preparing the sulfasalazine comprises the following steps:

s1, mixing the sulfasalazine powder and water, stirring and preparing the sulfasalazine ointment 3. The sulfasalazine powder is usually added with one or more of conventional disintegrating agent (such as starch, etc.), lubricant and glidant (such as talcum powder, superfine silica gel powder, hydrogenated vegetable oil, etc.). Mixing and stirring are usually completed in a conventional stirrer. Sulfasalazine ointment 3 is generally experimentally determined to have a suitable penetration for ease of application.

S2, coating the sulfasalazine ointment 3 on the film-making mold 1 to obtain the film-making mold 1 coated with the sulfasalazine ointment 3. The application of the sulfasalazine ointment 3 is generally performed on the above-described tableting device 2.

In S2, the method further includes a step S21 of pressing the sheeting die 1 coated with the sulfasalazine ointment 3. The weight stability of the salazosulfapyridine tablet 31 can be ensured.

After S21, the method further includes a step S22 of performing paste scraping on the top end of the sheet-making die 1. The weight stability of the salazosulfapyridine tablet 31 can be ensured.

S3, the tabletting mold 1 coated with the sulfasalazine ointment 3 is dried to obtain the tabletting mold 1 filled with the sulfasalazine tablet 31. The drying of the sheeting mold 1 coated with the sulfasalazine ointment 3 is generally performed in the sheeting drying apparatus 24.

S4, the upper mold 11 is moved closer to the lower mold 12 to push out the sulfasalazine tablet 31 by the tableting jack 121, thereby obtaining a sulfasalazine tablet 31.

S5, the tableting cavity 111 and the tableting top column 121 are cleaned. After the flaking chamber 111 and the flaking posts 121 are typically flushed with high pressure water, the flaking chamber 111 and the flaking posts 121 are blow dried with compressed air.

It is to be understood that the terms "central," "longitudinal," "lateral," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientations and positional relationships indicated in the drawings for the purpose of convenience and simplicity of description, and do not indicate or imply that the referenced devices or components must be in a particular orientation, constructed and operated in a particular orientation, and are not to be considered limiting of the scope of the present invention.

The above embodiments are merely preferred embodiments of the present disclosure, which are not intended to limit the present disclosure, and any modifications, equivalents, improvements and the like, which are within the spirit and principle of the present disclosure, should be included in the scope of the present disclosure.

Claims

1. The method for preparing the sulfasalazine is characterized in that a tablet preparation die (1) is used, and the tablet preparation die (1) comprises an upper die (11), a lower die (12) and a limiting piece (13); the upper die (11) is provided with a penetrating tabletting cavity (111), the lower die (12) is provided with a tabletting ejection column (121), and the tabletting ejection columns (121) are respectively inserted into the tabletting cavity (111) in a fitting manner; the limiting piece (13) comprises two limiting strips (131) which are parallel to each other and a limiting piece front end block (132), one ends of the two limiting strips (131) are fixedly connected with the limiting piece front end block (132), and the top end surfaces of the limiting strips (131) and the bottom end surfaces of the limiting strips (131) respectively abut against the upper die (11) and the lower die (12); the sheet making die (1) further comprises a locking piece (14), the locking piece (14) is provided with a locking column (141) in a downward extending mode, the front end of the upper die (11) and the front end of the lower die (12) are both provided with a limiting piece front end recess (133), the rear ends of the limiting strips (131) are both provided with a through locking hole (134), a limiting piece front end block (132) abuts against the limiting piece front end recess (133), the locking piece (14) abuts against the rear end of the upper die (11), and the locking column (141) respectively passes through the locking hole (134) in a fitting mode; the limiting piece (13) and the locking piece (14) are arranged around the tabletting top column (121) and the tabletting cavity (111),

s1, mixing sulfasalazine powder and water, stirring, and making into sulfasalazine ointment (3);

s2, coating the sulfasalazine ointment (3) on the film-making mold (1) to obtain the film-making mold (1) coated with the sulfasalazine ointment (3);

s3, drying the tablet forming die (1) coated with the sulfasalazine ointment (3) to obtain the tablet forming die (1) filled with the sulfasalazine tablet (31);

s4, the upper die (11) is moved closer to the lower die (12) to make the tabletting top column (121) eject the sulfasalazine tablet (31), and the sulfasalazine tablet (31) is obtained.

2. A method of tableting sulfasalazine as claimed in claim 1, wherein: in S2, the method further includes a step S21 of pressing the sheeting die (1) coated with the sulfasalazine ointment (3).

3. A method of tableting sulfasalazine as claimed in claim 2 wherein: after S21, the method further includes a step S22 of applying paste onto the tip of the sheet-making die (1).

4. A method of tableting sulfasalazine as claimed in claim 3, wherein: after S4, S5 is also included, and the tableting cavity (111) and the tableting top column (121) are cleaned.

5. A process for preparing a sulfasalazine tablet as claimed in claim 4, wherein: after the tabletting cavity (111) and the tabletting top column (121) are washed by high-pressure water, the tabletting cavity (111) and the tabletting top column (121) are dried by compressed air.