CN108992703A - A kind of preparation method of highly-breathable medical gel material - Google Patents
A kind of preparation method of highly-breathable medical gel material Download PDFInfo
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The present invention relates to a kind of preparation methods of highly-breathable medical gel material, belong to medical material tech field.The present invention is using Chinese aloe leaf as raw material, pass through dipping by lye boiling and cellulase degradation, again by ferric trichloride, sodium acetate, sodium citrate and ethylene glycol mixing high-temperature water cook to obtain nano ferriferrous oxide, to generate microcosmic microsphere particle, give full play to repair of the nutritional ingredient to human epidermal cell in the sterilizing effect and aloe of chitosan, the present invention first mixes chitosan with urea and potassium hydroxide to react under freezing conditions, strand is rolled up using cryogenic freezing, pass through carboxyl possessed in carboxymethyl cellulose, the intermolecular force of hydroxyl and each glucose to extraneous molecule, make more to be also easy to produce suction-operated between cellulose and chitosan, the formation of microballoon helps to increase the contact area of chitosan, enhance germicidal efficiency, there are holes between microballoon simultaneously, facilitate the ventilative effect of increase gel rubber material Fruit.
Description
Technical field
The present invention relates to a kind of preparation methods of highly-breathable medical gel material, belong to medical material tech field.
Background technique
Gel rubber material, also known as cementitious matter.Under physics, chemical action, firm Shi Zhuanti can be become from slurry, and can glue
Unclassified stores is tied, the substance of the complex solid of certain mechanical strength is formed with.It is all to pass through a series of objects in civil engineering material
Shot shape or bulk material can be bonded integral material by reason, chemical change, be referred to as gel rubber material.Gel rubber material refers to logical
The physics chemical action for crossing itself can glue shot or bulk material during becoming hard stone shape body from plasticity slurry
Form for whole material, also known as cementing material.
It is poly- that macromolecule hydrogel may be defined as the crosslinking that can be swollen in water and keep large quantity of moisture and cannot be dissolved
Close object.According to the difference of cross-linked network bonding mechanism, hydrogel can be divided into physical gel and chemical gel, and physical gel is to pass through
The gel that the modes such as the physical action such as entanglement of electrostatic interaction, hydrogen bond, chain are formed, this gel be it is non-permanent, by adding
Heat, gel can be changed into colloidal sol, so also referred to as heat-convertible gel.Chemical gel is having of being cross-linked to form by chemical bond
The polymer of three-dimensional net structure is permanent, also known as true gel.Injectable gel is the novel water-setting occurred in recent years
Gel Precursor with certain fluidity is implanted in vivo by glue by way of injection, and gel, which can be full of, entirely to be had
The defect of irregular character, operation wound are small.Injection aquagel acts not only as tissue renovation material, can also make
For surface of a wound sealing agent, it is closed the surface of a wound, prevents leakage, gas leakage.
The main indicator for evaluating dressing performance is as follows: mechanical performance；Bacterial barriers effect: ideal Wound dressing should be able to be right
Microorganism invasion plays the role of barrier.Adhesiveness: i.e. dressing is uniform, is closely adhere to the ability of the surface of a wound.Absorptive capacity: i.e.
Dressing absorbs the ability of wound fluid and harmful substance.Moisture-vapor transmission: moisture-vapor transmission appropriate can be such that the surface of a wound protects
An ideal humidity environment is held, it is wet to prevent from being also able to maintain the surface of a wound while hydrops, may advantageously facilitate healing.Oxygen is penetrating
Property: oxygen can be improved fibroblastic activity.
Wherein gas permeability and expansion rate of water absorption and disinfection effect have higher influence, related patent hair to gel rubber material
Bright medical gel material forms the powder solid content of supermolecule by polysaccharide and crosslinking action, and it is swollen to have very good water suction
Swollen rate.But the medical gel permeability of its preparation is undesirable and disinfection effect is bad.Therefore, it invents a kind of high
Gas medical gel material has positive effect to medical material tech field.
Summary of the invention
The technical problems to be solved by the invention: bad for current medical gel material disinfection effect, saturating simultaneously
The defect of gas effect difference, provides a kind of preparation method of highly-breathable medical gel material.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
A kind of preparation method of highly-breathable medical gel material, it is characterised in that specific preparation step are as follows:
(1) it weighs the chopping of 300~400g Chinese aloe leaf to be placed in a beaker, is poured into sodium hydroxide solution and impregnate Chinese aloe leaf in beaker,
It places the beaker constant temperature in water-bath to impregnate, be cooled to room temperature after immersion, it is mixed to the obtained solid-liquid of neutrality that salt acid for adjusting pH value is added dropwise
Close object；
(2) cellulase of solidliquid mixture quality 2~4% is added into above-mentioned beaker, places the beaker in sonic oscillation instrument,
Filtrate is obtained by filtration after oscillation, it is spare；
(3) according to parts by weight, 1.4~1.7 parts of ferric trichlorides, 4.8~5.2 parts of sodium acetates, 0.4~0.6 part of citric acid are weighed
It is uniformly mixed obtained mixed liquor in sodium and 80~90 parts of ethylene glycol investment reaction kettles, reaction kettle is heated up and carries out isothermal reaction, instead
Should after filter residue is obtained by filtration, be put into after being washed with distilled water 3~5 times in vacuum oven and dry reaction solid product be made；
(4) according to parts by weight, 3~5 parts of above-mentioned reaction solid products, 50~55 parts of spare filtrates, 1.0~1.2 parts are weighed
In urea and 14~18 parts of distilled water investment three-necked flasks, mixed emulsion is mixed with blender, three-necked flask is placed in micro-
It is heated in wave furnace, is put into vacuum oven and is concentrated and dried until product constant weight, is made reacting slurry after heating；
(5) according to parts by weight, 2~3 parts of chitosans, 6~7 parts of potassium hydroxide powders, 20~22 parts of urea powders and 60 are weighed
It is stirred evenly in~65 parts of distilled water investment beakers, places the beaker and stand obtained reactant in household freezer, according to parts by weight,
It will be stirred in 13~14 parts of above-mentioned reacting slurries, 20~22 parts of reactants and 1.5~1.8 parts of sodium carboxymethylcellulose investment beakers
It mixes, mixed glue solution is made；
(6) above-mentioned mixed glue solution is placed in reaction kettle, increases reactor temperature reaction, be added after reaction into reaction kettle mixed
2.0~2.5 times of glue quality of distilled water is closed, reaction is made prefabricated glue, prefabricated glue is poured into and is placed in vacuum in mold
In drying box, it is concentrated and dried until product constant weight, demoulding is to get highly-breathable medical gel material.
The mass fraction of sodium hydroxide solution as described in step (1) is 5~10%, and the bath temperature in water-bath is 95
~100 DEG C, constant temperature soaking time is 30~40min, and the mass fraction of hydrochloric acid is 5~8%.
Supersonic frequency in sonic oscillation instrument described in step (2) is 40~45kHz, and duration of oscillation is 50~60min.
For reaction kettle warming temperature described in step (3) to 190~210 DEG C, the isothermal reaction time is 2~3h, and vacuum is dry
Temperature is 50~55 DEG C in dry case, and vacuum degree is 80~100Pa, and drying time is 2~3h.
The revolving speed of blender described in step (4) is 400~450r/min, and mixing time is 60~70min, micro-
The power of wave furnace is 240~260W, and heating time is 3~5min, and the vacuum degree in vacuum oven is 80~100Pa, temperature
It is 40~45 DEG C.
Temperature in household freezer described in step (5) is -35~-30 DEG C, and time of repose is 5~6h, and speed of agitator is
2000~2200r/min, temperature are -25~-20 DEG C, and mixing time is 2~3h.
For reactor temperature temperature described in step (6) to 40~45 DEG C, the reaction time is 2~3h, revolving speed is 100~
120r/min, temperature are 40~45 DEG C, and the reaction time is 60~80min, and the vacuum degree in vacuum oven is 80~100Pa,
Temperature is 50~60 DEG C.
The method have the benefit that:
(1) Chinese aloe leaf is placed in lye by the present invention first impregnates, and is digested using cellulase to Chinese aloe leaf after immersion, so
Afterwards using ferric trichloride as raw material, high-temperature water cooks to obtain reaction solid product, then the Chinese aloe leaf for reacting solid product and enzymatic hydrolysis is mixed
It closes, and reacting slurry is made with microwave heating, then freeze chitosan and mixed be incorporated in household freezer of other reagents, after freezing
Reacting slurry is added and is mixed to prepare mixed glue solution at low temperature, finally mix mixed glue solution with water and is concentrated and dried is obtained high saturating
Gas medical gel material, the present invention, by dipping by lye boiling and cellulase degradation, make Chinese aloe leaf using Chinese aloe leaf as raw material
In nutritional ingredient, plant fiber and cellulose separation, then ferric trichloride, sodium acetate, sodium citrate and ethylene glycol mixed high
Warm water cooks to obtain nano ferriferrous oxide, and obtained nano ferriferrous oxide is mixed with ingredient each in aloe, adds after mixing
Enter chitosan, covalent bond, hydrogen bond are generated by each nutriment in the magnetism of ferroso-ferric oxide institute band itself and aloe and divides
Active force adsorbs between son, and there are also chitosans to generate coupled action to metal oxide, makes ferroso-ferric oxide to gas chromatography shape
At strong attraction, to generate microcosmic microsphere particle, microsphere particle helps to increase organic substance to extraneous contact
Surface area makees the reparation of human epidermal cell to give full play to nutritional ingredient in the sterilizing effect and aloe of chitosan
With the formation of microballoon can also form more hole, enhance the gas permeability of gel rubber material；
(2) present invention first reacts chitosan under freezing conditions with urea and potassium hydroxide mixing, is made point using cryogenic freezing
Subchain is rolled up, and adding sodium carboxymethylcellulose makes chitosan access carboxymethyl cellulose, by being had in carboxymethyl cellulose
Some carboxyls, hydroxyl and each glucose make to be easier to produce between cellulose and chitosan to the intermolecular force of extraneous molecule
Raw suction-operated, to form the nanosphere centered on chitosan around chitosan surface is attached to, the formation of microballoon has
The contact area for helping increase chitosan, enhances germicidal efficiency, while there are hole between microballoon, helps to increase gel rubber material
Air permeability effect.
Specific embodiment
It weighs the chopping of 300~400g Chinese aloe leaf to be placed in a beaker, be fallen with the sodium hydroxide solution that mass fraction is 5~10%
Entering and impregnate Chinese aloe leaf in beaker, places the beaker in the water-bath that bath temperature is 95~100 DEG C, constant temperature impregnates 30~40min,
It is cooled to room temperature after immersion, salt acid for adjusting pH value to the neutrality that mass fraction is 5~8% is added dropwise, solidliquid mixture is made；To above-mentioned
The cellulase of solidliquid mixture quality 2~4% is added in beaker, places the beaker in sonic oscillation instrument, is 40 in supersonic frequency
50~60min is vibrated under conditions of~45kHz, and filtrate is obtained by filtration after oscillation, it is spare；According to parts by weight, 1.4 are weighed~
In 1.7 parts of ferric trichlorides, 4.8~5.2 parts of sodium acetates, 0.4~0.6 part of sodium citrate and 80~90 parts of ethylene glycol investment reaction kettles
It is uniformly mixed obtained mixed liquor, reaction kettle is warming up to 190~210 DEG C, filter residue is obtained by filtration after reaction in 2~3h of isothermal reaction,
Being put into vacuum oven after being washed with distilled water 3~5 times in temperature is 50~55 DEG C, and vacuum degree is the condition of 80~100Pa
Reaction solid product is made in 2~3h of lower drying；According to parts by weight, 3~5 parts of above-mentioned reaction solid products, 50~55 parts are weighed
Spare filtrate, 1.0~1.2 parts of urea and 14~18 parts of distilled water are put into three-necked flasks, with blender with 400~450r/
The revolving speed of min is mixed 60~70min and mixed emulsion is made, and three-necked flask is placed in micro-wave oven, power be 240~
3~5min is heated under conditions of 260W, to be put into vacuum oven after heating with vacuum degree be 80~100Pa, temperature be 40~
It is concentrated and dried under conditions of 45 DEG C until product constant weight, is made reacting slurry；According to parts by weight, 2~3 parts of chitosans, 6 are weighed
It is stirred evenly in~7 parts of potassium hydroxide powders, 20~22 parts of urea powders and 60~65 parts of distilled water investment beakers, beaker is set
5~6h is stood under conditions of temperature is -35~-30 DEG C in household freezer, reactant is made, according to parts by weight, by 13~
In 14 parts of above-mentioned reacting slurries, 20~22 parts of reactants and 1.5~1.8 parts of sodium carboxymethylcellulose investment beakers, turn in stirring
Speed be 2000~2200r/min and temperature be -25~-20 DEG C under conditions of stir 2~3h, be made mixed glue solution；It will be above-mentioned mixed
It closes glue to be placed in reaction kettle, increases reactor temperature to 40~45 DEG C, epoxy glue is added into reaction kettle after reacting 2~3h
The distilled water that 2.0~2.5 times of liquid quality reacts 60 under conditions of revolving speed is 100~120r/min and temperature is 40~45 DEG C
Prefabricated glue is made in~80min, reaction, and it is 80 in vacuum degree in a vacuum drying oven that prefabricated glue, which is poured into juxtaposition in mold,
~100Pa and temperature are concentrated and dried under conditions of being 50~60 DEG C until product constant weight, demoulding is to get highly-breathable medical gel
Material.
It weighs the chopping of 300g Chinese aloe leaf to be placed in a beaker, is poured into beaker and soaked with the sodium hydroxide solution that mass fraction is 5%
Stain Chinese aloe leaf places the beaker in the water-bath that bath temperature is 95 DEG C, and constant temperature impregnates 30min, is cooled to room temperature after immersion, drips
Add salt acid for adjusting pH value to the neutrality that mass fraction is 5% that solidliquid mixture is made；Solidliquid mixture matter is added into above-mentioned beaker
The cellulase of amount 2%, places the beaker in sonic oscillation instrument, vibrates 50min under conditions of supersonic frequency is 40kHz, vibrates
After filtrate is obtained by filtration, it is spare；According to parts by weight, 1.4 parts of ferric trichlorides, 4.8 parts of sodium acetates, 0.4 part of sodium citrate are weighed
It is uniformly mixed obtained mixed liquor in 80 parts of ethylene glycol investment reaction kettles, reaction kettle is warming up to 190 DEG C, isothermal reaction 2h, instead
Should after filter residue is obtained by filtration, being put into vacuum oven after being washed with distilled water 3 times in temperature is 50 DEG C, and vacuum degree is 80Pa
Under the conditions of dry 2h reaction solid product is made；According to parts by weight, weigh 3 parts of above-mentioned reaction solid products, 50 parts it is spare
In filtrate, 1.0 parts of urea and 14 parts of distilled water investment three-necked flasks, it is mixed with blender with the revolving speed of 400r/min
Mixed emulsion is made in 60min, and three-necked flask is placed in micro-wave oven, 3min is heated under conditions of power is 240W, after heating
It is concentrated and dried under conditions of being put into vacuum oven with vacuum degree is 80Pa, temperature is 40 DEG C until product constant weight, is made anti-
Answer slurries；According to parts by weight, 2 parts of chitosans, 6 parts of potassium hydroxide powders, 20 parts of urea powders and 60 parts of distilled water are weighed to throw
Enter in beaker and stir evenly, place the beaker in household freezer and stand 5h under conditions of temperature is -35 DEG C, reactant is made, presses
Parts by weight meter is being stirred in 13 parts of above-mentioned reacting slurries, 20 parts of reactants and 1.5 parts of sodium carboxymethylcellulose investment beakers
Mix revolving speed be 2000r/min and temperature be -25 DEG C under conditions of stir 2h, be made mixed glue solution；Above-mentioned mixed glue solution is placed in
In reaction kettle, reactor temperature is increased to 40 DEG C, 2.0 times of mixed glue solution quality of distillation is added after reaction 2h into reaction kettle
Water reacts 60min under conditions of revolving speed is 100r/min and temperature is 40 DEG C, and prefabricated glue is made in reaction, by prefabricated glue
Juxtaposition in mold is poured into a vacuum drying oven, to be concentrated and dried under conditions of vacuum degree is 80Pa and temperature is 50 DEG C until producing
Object constant weight, demoulding is to get highly-breathable medical gel material.
It weighs the chopping of 350g Chinese aloe leaf to be placed in a beaker, is poured into beaker and soaked with the sodium hydroxide solution that mass fraction is 7%
Stain Chinese aloe leaf places the beaker in the water-bath that bath temperature is 97 DEG C, and constant temperature impregnates 35min, is cooled to room temperature after immersion, drips
Add salt acid for adjusting pH value to the neutrality that mass fraction is 7% that solidliquid mixture is made；Solidliquid mixture matter is added into above-mentioned beaker
The cellulase of amount 3%, places the beaker in sonic oscillation instrument, vibrates 55min under conditions of supersonic frequency is 42kHz, vibrates
After filtrate is obtained by filtration, it is spare；According to parts by weight, 1.6 parts of ferric trichlorides, 5.0 parts of sodium acetates, 0.5 part of sodium citrate are weighed
It is uniformly mixed obtained mixed liquor in 85 parts of ethylene glycol investment reaction kettles, reaction kettle is warming up to 200 DEG C, isothermal reaction 2.5h,
Filter residue is obtained by filtration after reaction, being put into vacuum oven after being washed with distilled water 4 times in temperature is 52 DEG C, vacuum degree 90Pa
Under conditions of dry 2.5h reaction solid product is made；According to parts by weight, weigh 4 parts of above-mentioned reaction solid products, 52 parts it is standby
In filtrate, 1.1 parts of urea and 16 parts of distilled water investment three-necked flasks, it is mixed with blender with the revolving speed of 420r/min
Mixed emulsion is made in 65min, and three-necked flask is placed in micro-wave oven, 4min is heated under conditions of power is 250W, after heating
It is concentrated and dried under conditions of being put into vacuum oven with vacuum degree is 90Pa, temperature is 42 DEG C until product constant weight, is made anti-
Answer slurries；According to parts by weight, 2 parts of chitosans, 6 parts of potassium hydroxide powders, 21 parts of urea powders and 62 parts of distilled water are weighed to throw
Enter in beaker and stir evenly, place the beaker in household freezer and stand 5.5h under conditions of temperature is -32 DEG C, reactant is made,
According to parts by weight, 13 parts of above-mentioned reacting slurries, 21 parts of reactants and 1.7 parts of sodium carboxymethylcelluloses are put into beakers,
Speed of agitator be 2100r/min and temperature be -22 DEG C under conditions of stir 2.5h, be made mixed glue solution；By above-mentioned mixed glue solution
It is placed in reaction kettle, increases reactor temperature to 42 DEG C, 2.2 times of mixed glue solution quality are added into reaction kettle after reacting 2.5h
Distilled water, react 70min under conditions of revolving speed is 110r/min and temperature is 42 DEG C, prefabricated glue is made in reaction, will be pre-
Glue liquid pours into juxtaposition in mold and in a vacuum drying oven, is concentrated and dried under conditions of vacuum degree is 90Pa and temperature is 55 DEG C
Until product constant weight, demoulding is to get highly-breathable medical gel material.
It weighs the chopping of 400g Chinese aloe leaf to be placed in a beaker, be poured into beaker with the sodium hydroxide solution that mass fraction is 10%
Chinese aloe leaf is impregnated, is placed the beaker in the water-bath that bath temperature is 100 DEG C, constant temperature impregnates 40min, is cooled to room after immersion
Temperature is added dropwise salt acid for adjusting pH value to the neutrality that mass fraction is 8% and solidliquid mixture is made；It is mixed that solid-liquid is added into above-mentioned beaker
The cellulase for closing amount of substance 4%, places the beaker in sonic oscillation instrument, vibrates under conditions of supersonic frequency is 45kHz
Filtrate is obtained by filtration in 60min after oscillation, spare；According to parts by weight, 1.7 parts of ferric trichlorides, 5.2 parts of sodium acetates, 0.6 are weighed
It is uniformly mixed obtained mixed liquor in part sodium citrate and 90 parts of ethylene glycol investment reaction kettles, reaction kettle is warming up to 210 DEG C, constant temperature
3h is reacted, filter residue is obtained by filtration after reaction, being put into vacuum oven after being washed with distilled water 5 times in temperature is 55 DEG C, vacuum
Degree dry obtained reaction solid product of 3h under conditions of being 100Pa；According to parts by weight, weigh 5 parts of above-mentioned reaction solid products,
It is mixed with the revolving speed of 450r/min with blender in 55 parts of spare filtrates, 1.2 parts of urea and 18 parts of distilled water investment three-necked flasks
It closes stirring 70min and mixed emulsion is made, three-necked flask is placed in micro-wave oven, heats 5min under conditions of power is 260W,
It is concentrated and dried under conditions of being put into vacuum oven after heating with vacuum degree is 100Pa, temperature is 45 DEG C up to product constant weight,
Reacting slurry is made；According to parts by weight, 3 parts of chitosans, 7 parts of potassium hydroxide powders, 22 parts of urea powders and 65 parts of steamings are weighed
It is stirred evenly in distilled water investment beaker, places the beaker in household freezer and stand 6h under conditions of temperature is -30 DEG C, reaction is made
Object according to parts by weight puts into 14 parts of above-mentioned reacting slurries, 22 parts of reactants and 1.8 parts of sodium carboxymethylcelluloses in beakers,
3h is stirred under conditions of speed of agitator is 2200r/min and temperature is -20 DEG C, mixed glue solution is made；By above-mentioned mixed glue solution
It is placed in reaction kettle, increases reactor temperature to 45 DEG C, 2.5 times of mixed glue solution quality are added into reaction kettle after reacting 3h
Distilled water reacts 80min under conditions of revolving speed is 120r/min and temperature is 45 DEG C, and prefabricated glue is made in reaction, will be prefabricated
Glue pours into juxtaposition in mold and in a vacuum drying oven, is concentrated and dried under conditions of vacuum degree is 100Pa and temperature is 60 DEG C
Until product constant weight, demoulding is to get highly-breathable medical gel material.
The highly-breathable medical gel material that comparative example is produced with Shaanxi company is as a comparison case to produced by the present invention
Highly-breathable medical gel material in highly-breathable medical gel material and comparative example carries out performance detection, testing result such as table
Shown in 1:
Test method:
Expansion rate of water absorption test: the medical gel material in example 1~3 and comparative example is dried in vacuo, and is distinguished after dry
Write down weight.Medical gel material after drying is impregnated into 12h into the water, the weight of gel rubber material after water suction is calculated after 12h.
Weight and the weight multiple of gel rubber material dry before water suction are as follows after water suction:
Sterilizing test: the medical gel material in example 1~3 and comparative example is used for the reparation of human epidermal cell
In, medical gel material is removed after a period of time, and measure the clump count of epidermis, obtain bacteriostasis rate.
Escherichia coli bacteriostasis rate, which is tested, carries out bacteriostasis property detection by the regulation of JC/T897-2002.
Staphylococcus aureus bacteriostasis rate number, which is tested, carries out bacteriostasis property detection by the regulation of JC/T897-2002.
Candida albicans bacteriostasis rate, which is tested, carries out performance detection by the regulation of GB/T20944.2-2007.
1 medical gel material property measurement result of table
| Test item | Example 1 | Example 2 | Example 3 | Comparative example |
| Weight multiple after water suction | 63 | 65 | 67 | 40 |
| Porosity (%) | 9.3 | 94 | 95 | 70 |
| Escherichia coli bacteriostasis rate (%) | 99.85 | 99.92 | 99.99 | 82.56 |
| Staphylococcus aureus bacteriostasis rate (%) | 99.78 | 99.88 | 99.99 | 81.25 |
| Candida albicans bacteriostasis rate (%) | 99.56 | 99.78 | 99.99 | 80.43 |
High, the biofacies according to weight multiple after the highly-breathable medical gel material water suction produced by the present invention of data among the above
Capacitive and expansion rate of water absorption are high, and porosity is high, and good permeability, disinfection effect is good, all reach 99.99%, have wide answer
Use prospect.
Claims (7)
1. a kind of preparation method of highly-breathable medical gel material, it is characterised in that specific preparation step are as follows:
(1) it weighs the chopping of 300~400g Chinese aloe leaf to be placed in a beaker, is poured into sodium hydroxide solution and impregnate Chinese aloe leaf in beaker,
It places the beaker constant temperature in water-bath to impregnate, be cooled to room temperature after immersion, it is mixed to the obtained solid-liquid of neutrality that salt acid for adjusting pH value is added dropwise
Close object；
(2) cellulase of solidliquid mixture quality 2~4% is added into above-mentioned beaker, places the beaker in sonic oscillation instrument,
Filtrate is obtained by filtration after oscillation, it is spare；
(3) according to parts by weight, 1.4~1.7 parts of ferric trichlorides, 4.8~5.2 parts of sodium acetates, 0.4~0.6 part of citric acid are weighed
It is uniformly mixed obtained mixed liquor in sodium and 80~90 parts of ethylene glycol investment reaction kettles, reaction kettle is heated up and carries out isothermal reaction, instead
Should after filter residue is obtained by filtration, be put into after being washed with distilled water 3~5 times in vacuum oven and dry reaction solid product be made；
(4) according to parts by weight, 3~5 parts of above-mentioned reaction solid products, 50~55 parts of spare filtrates, 1.0~1.2 parts are weighed
In urea and 14~18 parts of distilled water investment three-necked flasks, mixed emulsion is mixed with blender, three-necked flask is placed in micro-
It is heated in wave furnace, is put into vacuum oven and is concentrated and dried until product constant weight, is made reacting slurry after heating；
(5) according to parts by weight, 2~3 parts of chitosans, 6~7 parts of potassium hydroxide powders, 20~22 parts of urea powders and 60 are weighed
It is stirred evenly in~65 parts of distilled water investment beakers, places the beaker and stand obtained reactant in household freezer, according to parts by weight,
It will be stirred in 13~14 parts of above-mentioned reacting slurries, 20~22 parts of reactants and 1.5~1.8 parts of sodium carboxymethylcellulose investment beakers
It mixes, mixed glue solution is made；
(6) above-mentioned mixed glue solution is placed in reaction kettle, increases reactor temperature reaction, be added after reaction into reaction kettle mixed
2.0~2.5 times of glue quality of distilled water is closed, reaction is made prefabricated glue, prefabricated glue is poured into and is placed in vacuum in mold
In drying box, it is concentrated and dried until product constant weight, demoulding is to get highly-breathable medical gel material.
2. a kind of preparation method of highly-breathable medical gel material according to claim 1, it is characterised in that: step
(1) mass fraction of the sodium hydroxide solution described in is 5~10%, and the bath temperature in water-bath is 95~100 DEG C, constant temperature
Soaking time is 30~40min, and the mass fraction of hydrochloric acid is 5~8%.
3. a kind of preparation method of highly-breathable medical gel material according to claim 1, it is characterised in that: step
(2) supersonic frequency in sonic oscillation instrument described in is 40~45kHz, and duration of oscillation is 50~60min.
4. a kind of preparation method of highly-breathable medical gel material according to claim 1, it is characterised in that: step
(3) the reaction kettle warming temperature described in is to 190~210 DEG C, and the isothermal reaction time is 2~3h, and temperature is in vacuum oven
50~55 DEG C, vacuum degree is 80~100Pa, and drying time is 2~3h.
5. a kind of preparation method of highly-breathable medical gel material according to claim 1, it is characterised in that: step
(4) revolving speed of the blender described in is 400~450r/min, and mixing time is 60~70min, and the power of micro-wave oven is
240~260W, heating time are 3~5min, and the vacuum degree in vacuum oven is 80~100Pa, temperature is 40~45 DEG C.
6. a kind of preparation method of highly-breathable medical gel material according to claim 1, it is characterised in that: step
(5) temperature in household freezer described in is -35~-30 DEG C, and time of repose is 5~6h, and speed of agitator is 2000~2200r/
Min, temperature are -25~-20 DEG C, and mixing time is 2~3h.
7. a kind of preparation method of highly-breathable medical gel material according to claim 1, it is characterised in that: step
(6) the reactor temperature temperature described in is to 40~45 DEG C, and the reaction time is 2~3h, and revolving speed is 100~120r/min, temperature
Degree is 40~45 DEG C, and the reaction time is 60~80min, and the vacuum degree in vacuum oven is 80~100Pa, and temperature is 50~60
℃。
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