CN108992038A - System for monitoring intraocular pressure and intraocular pressure monitoring method - Google Patents

System for monitoring intraocular pressure and intraocular pressure monitoring method Download PDF

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Publication number
CN108992038A
CN108992038A CN201810911621.3A CN201810911621A CN108992038A CN 108992038 A CN108992038 A CN 108992038A CN 201810911621 A CN201810911621 A CN 201810911621A CN 108992038 A CN108992038 A CN 108992038A
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intraocular pressure
monitoring
pressure
processing unit
unit
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CN108992038B (en
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杨兴
姚嘉林
胡越铭
骆凯
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Tsinghua University
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Tsinghua University
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Priority to PCT/CN2019/097210 priority patent/WO2020029792A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
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  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The invention discloses a kind of system for monitoring intraocular pressure and intraocular pressure monitoring methods.The system for monitoring intraocular pressure includes internal body portion and outer body, and the internal body portion is used for the intraocular parameter of real-time monitoring, carries out signal condition, sends and receives signal；The outer body is used to carry out internal body portion wireless energy supply, and the data spread out of to internal body portion are received, information merges and processing；Wherein, the internal body portion includes at least one monitoring unit, and the monitoring unit includes at least two sensors, and the sensor is for monitoring intraocular pressure parameter；The outer body includes at least one multi-sensor information fusion module, is analyzed and processed by information fusion technology to the data received.The present invention obtains intraocular pressure and other parameters by reasonably arranging multiple sensors in monitoring unit, using multi-sensor information fusion technology, to effectively improve the reliability and detection accuracy of intraocular pressure monitoring.

Description

System for monitoring intraocular pressure and intraocular pressure monitoring method
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of system for monitoring intraocular pressure.The invention further relates to a kind of intraocular pressures Monitoring method.
Background technique
Glaucoma is that intraocular pressure is excessively caused to continue or be interrupted to increase due to intraocular aqueous humor, is damaged more than the degree that eyeball is resistant to The eye disease of evil optic nerve.Measurement intraocular pressure has the diagnosis and treatment of glaucoma patient extremely important continuously for a long time Meaning.
Be put into microsensor within the eye by the method for implantation and composition real-time monitoring system be likely to be one kind can be real The method of intraocular pressure is now continuously monitored for a long time.However, at present in document and the implanted intraocular pressure monitoring device and method reported One or a kind of sensor are often only used, thus in terms of having the disadvantage that (1) detection accuracy: the intraocular pressure data class measured Type is relatively single, and patient routine work and life in there are static, movement, acceleration and deceleration, Temperature changing, position chanP etc. are more Kind complex situations, these situations can affect to the accurate measurement of intraocular pressure, therefore can not obtain more accurately, reliably Intraocular pressure data and information；(2) in terms of reliability: due to only using a pressure sensor detection intraocular pressure, when the pressure sensing When device breaks down or fails, implanted intraocular pressure monitoring device also fails immediately.More seriously, single pressure sensor due to The wrong intraocular pressure information that trouble or failure provides can not be corrected, to will lead to doctor and patient progress false judgment, mistake Maloperation and treatment.In addition to this, the implant surgery for carrying out intraocular pressure monitoring device again, is likely to cause new one to patient's body and mind Take turns wound；(3) intelligent aspect: current intraocular pressure monitoring method does not refer to information fusion technology, however patient is in routine work It with Various Complex situation present in life, needs to work in coordination using multiple or multiple sensors, while acquiring multiple or more Kind signal carries out comprehensive analysis and judgement, could improve the intelligence of system.
In addition, although some tonometries reported in the literature at present and monitoring device refer to use multisensor, but one Aspect does not provide the reason of carrying out intraocular pressure monitoring using multisensor and purpose and how to carry out multiple or multiple sensors It is reasonable arrangement and cooperation, on the other hand be not given by yet multisensor information carry out fusion treatment method and calculation Method.
In short, implanted intraocular pressure monitoring device in the prior art and method, which are difficult to meet, carries out high precision to patient's intraocular pressure Property, high reliability, the demand of intelligentized real-time monitoring.
Summary of the invention
Based on above-mentioned status, the main purpose of the present invention is to provide a kind of system for monitoring intraocular pressure and intraocular pressure monitoring method, It, come real-time monitoring intraocular pressure, can not only improve the reliability and measurement essence of intraocular pressure monitoring using multi-sensor information fusion technology Degree, moreover it is possible in intraocular pressure exception, person monitored is reminded in time, to avoid the optic nerve injury of person monitored.
To achieve the above object, The technical solution adopted by the invention is as follows:
A kind of system for monitoring intraocular pressure, including internal body portion and outer body, the internal body portion are intraocular for real-time monitoring Parameter carries out signal condition, sends and receives signal；The outer body is used to carry out wireless energy supply to internal body portion, and right The data of internal body portion outflow are received, information merges and processing；
Wherein, the internal body portion includes at least one monitoring unit, and the monitoring unit includes at least two sensors, The sensor is for monitoring intraocular pressure parameter；
The outer body includes at least one multi-sensor information fusion module, by information fusion technology to receiving Data be analyzed and processed.
Preferably, the monitoring unit includes at least one pressure sensor for being used to monitor intraocular pressure.
Preferably, the monitoring unit further includes at least one drainage tube, in the drainage tube and the monitoring unit The connection of at least one pressure sensor；
The drainage tube is for being inserted into eyeball, so as to drain aqueous humor to monitoring unit.
Preferably, the outer body includes at least one sensor.
Preferably, the outer body includes at least one pressure sensor, for monitoring atmospheric pressure；
And/or the outer body includes at least one acceleration transducer and/or at least one gyro sensor, For measuring and/or monitoring the acceleration and/or angular speed of person's body monitored, the system for monitoring intraocular pressure is passed through The acceleration and/or angular speed and/or posture that monitor person's body monitored improve the precision of tonometry；
And/or the outer body includes at least one temperature sensor, for measure and/or monitor person monitored and/ Or the temperature of environment, so that the system for monitoring intraocular pressure is it can be considered that or exclude the influence that monitors to intraocular pressure of temperature change.
Preferably, the monitoring unit includes at least one acceleration transducer and/or at least one gyro sensor, For monitoring the acceleration and/or angular speed on person head monitored, enable the system for monitoring intraocular pressure monitor acceleration and/ Or influence of the angular speed to intraocular pressure；
And/or the monitoring unit includes at least one temperature sensor, for monitoring the body temperature of person monitored, The system for monitoring intraocular pressure is enabled to monitor influence of the body temperature variation to intraocular pressure.
Preferably, the outer body includes signal relay unit and host computer processing unit, the signal relay unit For receiving the supplemental characteristic of the internal body portion transmission, and the data received are reported to the host computer processing unit, At least one described multi-sensor information fusion module is arranged in the host computer processing unit.
Preferably, the outer body further includes cloud processing unit, the cloud processing unit can with it is described upper Machine processing unit is communicated, and to receive and store the supplemental characteristic from the host computer processing unit, and can be utilized Multi-sensor information fusion technology analyzes the data received again, and analysis result is fed back to the host computer and is handled Unit.
Preferably, the signal relay unit is suitable for being worn on head, chest, trunk and/or the four limbs of person monitored.
A kind of intraocular pressure monitoring method, uses mentioned-above system for monitoring intraocular pressure, the system for monitoring intraocular pressure it is external Part includes signal relay unit and host computer processing unit；The intraocular pressure monitoring method comprising steps of
S10, the internal body portion monitor the intraocular pressure of person monitored, and pressure signal is converted into electric signal；
Monitoring data are sent to the signal relay unit by S20, the internal body portion；
Data from the internal body portion are sent to the host computer processing unit by S30, the signal relay unit；
S40, the host computer processing unit are analyzed and processed the data received using information fusion technology；
Whether extremely S50, the host computer processing unit judge intraocular pressure according to processing result, and provide when intraocular pressure is normal Intraocular pressure information issues standby signal when confirming intraocular pressure exception.
Preferably, the monitoring unit includes at least two pressure sensors；In step S50, the host computer processing is single Member is according to the data of two or more pressure sensors, by data anastomosing algorithm comprehensive descision, the case where obtaining intraocular pressure And data.
Preferably, in step S50, the host computer processing unit judges intraocular pressure situation, and is meeting following three kinds of conditions In any situation when can be diagnosed as intraocular pressure exception:
(1) intraocular pressure is more than a millimetres of mercury,
(2) eyes pressure difference is greater than b millimetres of mercury,
(3) intraocular pressure difference is more than c millimetres of mercury in t1 hours.
Wherein, t1=1~100, a=3~80, b=3~10, c=3~30.
Preferably, the monitoring unit or the signal relay unit include at least one acceleration transducer and/or At least one gyro sensor；In step S50, the host computer processing unit is according to acceleration and/or angular-rate sensor Measurement result the measurement result of intraocular pressure is corrected or is compensated, and be confirmed as intraocular pressure with acceleration and/or angular speed When fluctuation is more than predetermined limits, standby signal is issued.
Preferably, the monitoring unit includes at least one pressure sensor and at least one temperature sensor；
In step S10, the monitoring unit also monitors the body temperature of person monitored, and temperature signal is converted into telecommunications Number；
In step S50, the host computer processing unit first generates the pressure sensor with internal temperature change Temperature drift be modified, obtain revised pressure value, judge whether intraocular pressure different according still further to revised pressure value later Often.
Preferably, the system for monitoring intraocular pressure includes cloud processing unit；Step S50 comprising steps of
S510, the host computer processing unit will analyze treated data and/or untreated data are transmitted to institute State cloud processing unit；
S520, the cloud processing unit analyze the data received using information fusion technology again, and will divide Analysis result feeds back to the host computer processing unit；
Whether extremely S530, the host computer processing unit judge intraocular pressure according to the feedback information received, and are confirming To issue standby signal when intraocular pressure exception.
The present invention in monitoring unit by reasonably arranging multiple sensors, using multi-sensor information fusion technology Intraocular pressure and other parameters are obtained, to effectively improve the reliability and detection accuracy of intraocular pressure monitoring.
Detailed description of the invention
Hereinafter reference will be made to the drawings to the preferred embodiment of system for monitoring intraocular pressure according to the present invention and intraocular pressure monitoring method It is described.In figure:
Fig. 1 is a kind of the Nomenclature Composition and Structure of Complexes schematic diagram of the system for monitoring intraocular pressure of preferred embodiment according to the present invention；
Fig. 2 is a kind of structural schematic diagram of the monitoring unit of preferred embodiment according to the present invention；
Fig. 3 is a kind of structural schematic diagram of the monitoring unit of preferred embodiment according to the present invention, wherein only illustrating The arrangement of sensor；
Fig. 4 is the structural schematic diagram of the monitoring unit of another preferred embodiment according to the present invention, wherein only illustrating The arrangement of sensor；
Fig. 5 is the structural schematic diagram of the monitoring unit of another preferred embodiment according to the present invention, wherein only illustrating The arrangement of sensor；
Fig. 6 is a kind of structural schematic diagram of the signal relay unit of preferred embodiment according to the present invention；
Fig. 7 is the structural schematic diagram of the monitoring unit of yet another preferred form according to the present invention, wherein only illustrating The arrangement of sensor；
Fig. 8 is the structural schematic diagram of the monitoring unit of according to the present invention and another preferred embodiment, wherein only showing It has anticipated the arrangement of sensor；
Fig. 9 is the structural schematic diagram of monitoring unit according to the present invention and yet another preferred form, wherein only showing It has anticipated the arrangement of sensor；
Figure 10 is the structural schematic diagram of the monitoring unit of still another preferred embodiment according to the present invention, wherein only showing It has anticipated the arrangement of sensor.
Figure 11 is the structural schematic diagram of the monitoring unit of still another preferred embodiment according to the present invention, wherein only showing It has anticipated the arrangement of sensor.
Figure 12 is that a kind of monitoring unit of preferred embodiment according to the present invention is implanted into simultaneously in eyeball and in cranial cavity Schematic diagram；
Figure 13 is that a kind of monitoring unit of preferred embodiment according to the present invention is implanted into intraocular schematic diagram；
Figure 14 is that the monitoring unit of another preferred embodiment according to the present invention is implanted into intraocular schematic diagram；
Figure 15 is a kind of flow chart of the intraocular pressure monitoring method of preferred embodiment according to the present invention；
Figure 16 is the flow chart of the intraocular pressure monitoring method of another preferred embodiment according to the present invention；
Description of symbols
100 internal body portion, 110 monitoring unit, 111 intraocular pressure monitoring modular 111a pressure sensor 111b pressure sensing 112 temperature monitoring mould of device 111c pressure sensor 111d pressure sensor 111e pressure sensor 111f pressure sensor 113 acceleration monitoring module 113a acceleration transducer 113b of block 112a temperature sensor 112b temperature sensor accelerates Spend 114 angular speed monitoring modular 114a gyro sensor 114b gyro sensor of sensor, 115 monitoring intracranial pressure mould 120 signal conditioning unit of block 115a pressure sensor 116a heart rate sensor 117a blood glucose sensor, 130 wireless telecommunications list First 140 energy receive and 150 drainage tube 150a drainage tube 150b drainage tube 150c drainage tube of feed unit, 151 drainage tube 152 drainage tube, 200 outer body, 210 signal relay unit, 211 power module, 212 power management module, 213 signal receives The processing of 221 multi-sensor information fusion module of module 214 signal transmission module, 220 host computer processing unit, 230 cloud is single Member
Specific embodiment
The first aspect of the present invention provides a kind of system for monitoring intraocular pressure, as shown in Figure 1, including internal body portion 100 and body Outer portion 200, wherein internal body portion includes that monitoring unit 110, signal conditioning unit 120, wireless communication unit 130 and the energy connect Receipts and feed unit 140, outer body includes signal relay unit 210, host computer processing unit 220, cloud processing unit 230。
The fit system of more than 1. kinds and multiple sensors
In system for monitoring intraocular pressure of the invention, the type and quantity of sensor, which can according to need, arranges in pairs or groups, to obtain Different monitoring effects.
Implanted intraocular pressure monitoring device in the prior art detects intraocular pressure due to only using one or a kind of pressure sensor, In terms of having the disadvantage that (1) detection accuracy: the intraocular pressure data type measured is relatively single, and patient is in routine work With, there are Various Complexes situations such as static, movement, acceleration and deceleration, Temperature changing, position chanPs, these situations can be to intraocular pressure in life Accurate measurement affect, therefore can not obtain more accurate, reliable intraocular pressure data and information.(2) reliability Aspect: due to only using a pressure sensor detection intraocular pressure, when the pressure sensor breaks down or fails, implanted eye Pressure monitoring device also fails immediately.More seriously, the wrong intraocular pressure letter that single pressure sensor is provided due to trouble or failure Breath can not be corrected, to will lead to doctor and patient's progress false judgment, faulty operation and treatment.In addition to this, again The implant surgery for carrying out intraocular pressure monitoring device, is likely to cause new round wound to patient's body and mind.(3) intelligent aspect: at present Intraocular pressure monitoring method do not refer to information fusion technology, however patient's Various Complex feelings present in routine work and life Condition needs to work in coordination using multiple or multiple sensors, while acquiring multiple or multi-signal and carrying out comprehensive analysis and judgement, The intelligence of system could be improved.Therefore measurement accuracy, reliability, the intelligence etc. of implanted intraocular pressure monitoring device need to be mentioned It is high.
Based on summary of the invention, we can be designed system for monitoring intraocular pressure according to reliability theory, error theory And selection.
The definition of reliability is product under the defined conditions and in the defined time, completes the ability of predetermined function.It can Probability metrics by property are generally denoted as R (t) reliability.The available function representation about time t of Reliability Function, can indicate For
R (t)=P (T > t) (formula 1)
Wherein, t is the defined time, and T indicates the service life of product, and P (E) is the probability of generation event E.
By the definition of reliability it is found that R (t) describes product probability intact within (0, the t) time, and R (0)=1, R (+∞)=0.When beginning to use, all products are all good；As long as the time is sufficiently long, all over products can all fail.
Correspondingly, there are unreliable degree F (t) or accumulated invalid probability.Then have:
+ F (t)=1 R (t) (formula 2)
The derivative for defining accumulated invalid probability F (t) is f (t), then f (t) indicates product in the mistake of the unit time of t moment Probability is imitated, then is had:
Wherein, t is the defined time, and n (t) indicates that t moment, the product number for failing to complete predetermined function, N are indicated at this The product number that section start time devotes oneself to work.
Re-defining crash rate λ (t) is the product that work is not yet failed to t moment, is sent out within the unit time after moment t The probability of raw failure.
Then indicated with new probability formula are as follows:
Further:
Due to:
F (t)=- R ' (t)
R ' (t)=- f (t)
That is:
Thus the relational expression of reliability and crash rate is obtained:
Assuming that a working sensor year proportion of goods damageds in existing implanted intraocular pressure monitoring device are 1%, i.e., one sensing The probability that fails is 1% after device works 1 year, then, in the case where reliability is constant, how by existing implanted intraocular pressure Does is the working life of monitoring device increased to 10 years? even 20 years?
Failure probability can be obtained according to above-mentioned formula 2 and formula 5:
A pressure sensor working year proportion of goods damageds in so existing implanted intraocular pressure monitoring device can obtain for 1%,
In order to improve the working life of existing implanted intraocular pressure monitoring device to 10 years, implanted intraocular pressure monitoring device can be adopted It is worked with multiple uniform pressure sensors, is sent out by the existing implanted intraocular pressure monitoring device containing only a pressure sensor together Raw failure probability is 1%, then hasPressure sensing can be obtained Device quantity n is 1.95, i.e., existing implanted intraocular pressure monitoring device is worked together using 2 uniform pressure sensors, be can be improved existing There is the working life of implanted intraocular pressure monitoring device to 10 years or more.Similarly, when setting working life as 20 years, pressure can be obtained Number of sensors n is 2.70, i.e., existing implanted intraocular pressure monitoring device is worked together using 3 uniform pressure sensors, can be mentioned The working life of high existing implanted intraocular pressure monitoring device was to 20 years or more.
Based on the mentality of designing of above-mentioned implanted intraocular pressure monitoring device, monitoring unit 100 of the invention includes two or more Pressure sensor, even if one of pressure sensor fails, at least can also remain next pressure sensor can be worked normally, Corresponding monitoring unit 110 is also just still effective, and therefore, system for monitoring intraocular pressure of the invention can also effectively delay to implant The failure of monitoring unit 110 reduce pain to reduce the risk that person monitored bears second operation.
In addition, implanted intraocular pressure monitoring device in the prior art, is often only surveyed using one or a kind of pressure sensor Intraocular pressure data it is relatively single, and patient routine work and life in there are static, movement, acceleration and deceleration, Temperature changings, body The Various Complexes situations such as position variation, these situations can affect to the accurate measurement of intraocular pressure, it is therefore desirable to using more A or multiple sensors are worked in coordination, while being acquired multiple or multi-signal and being carried out comprehensive analysis and judgement, can just be obtained more Accurately, reliably intraocular pressure data and information.Thus this problem can cause implanted intraocular pressure in the prior art to be supervised than more prominent Accurate, comprehensive, efficient detection cannot be carried out to intraocular pressure by surveying device.And system for monitoring intraocular pressure of the present invention can then overcome this A little problems, preferred embodiment are as follows:
Two or more pressure sensors are arranged in (intraocular) part 100 in 1.1 bodies
Preferably, as shown in figure 3, the monitoring unit 110 includes at least two pressure sensor 111a being arranged in juxtaposition And 111b, i.e. at least two pressure sensor 111a and 111b installation sites are close to each other, and measurement direction is identical.Wherein, each Pressure sensor can convert corresponding electric signal for the intraocular pressure force parameter of person monitored, as shown in Figure 1, the energy receives (preferably close range wireless communication is connect in a manner of coil coupling with feed unit 140 with the signal relay unit 210 (NFC) mode connects), the electric signal transmission that the signal relay unit 210 acquires the internal body portion 100 is on described Position machine processing unit 220, what the host computer processing unit 220 acquired the monitoring unit 110 using information fusion technology Signal is handled, and thus can obtain at least two groups intraocular pressure data of person monitored in real time.
For example, when two or more pressure sensors are arranged in described (intraocular) part 100 in vivo, and the two or When the consistency for the multiple groups intraocular pressure data that more than two pressure sensors measure is bad, body can be judged according to error theory The reliability of inner sensor, person monitored needs to contact doctor in time and calibrates intracorporal pressure sensor when occurring abnormal, from And the intraocular pressure data of person monitored can be corrected, or exclude the wrong intraocular pressure data of person monitored；For example, as shown in figure 4, described More than two pressure sensor 111a, 111b and 111c are arranged in monitoring unit 110, what multiple pressure sensors detected The average value of intraocular pressure data is MmmHg, if the intraocular pressure data n that any pressure sensor detects in monitoring unit 110 and flat Difference > dmmHg of mean value M, wherein d is preset deviation, preferred d >=0.1, then illustrates intracorporal pressure sensor at this time Reliability has to be tested, and person monitored needs to contact doctor in time and calibrates intracorporal pressure sensor, is supervised so as to correct The intraocular pressure data of survey person, or exclude the wrong intraocular pressure data of person monitored；If any pressure sensor in monitoring unit 110 Difference≤dmmHg of the intraocular pressure data n and average value M that detect, then illustrate that vivo sensing device can work normally, intraocular pressure is pressure The average value of data；
As it can be seen that passing through the two pressure above sensors when monitoring unit 110 includes more than two pressure sensors Information fusion, can reliability to each pressure sensor itself and accuracy verify, to improve intraocular pressure monitoring Precision.
1.2 internal body portions arrange that two pressure sensors, outer body arrange the sensor of a survey atmospheric pressure
Preferably, the first absolute pressure transducer 111a and second is arranged side by side in monitoring unit 110 shown in Fig. 3 Absolute pressure transducer 111b, and third absolute pressure transducer is arranged in the outer body of the system for monitoring intraocular pressure 200 111c, such as third absolute pressure transducer 111c and its signal conditioning module 120 are mounted directly or are integrated at host computer It manages in unit 220.Because the first absolute pressure transducer 111a, the second absolute pressure transducer 111b pressure measured are higher than in vitro Pressure (i.e. atmospheric pressure), and the pressure that third absolute pressure transducer 111c is measured is equal to atmospheric pressure, therefore, the first absolute pressure The average value of the output of sensor 111a, the second absolute pressure transducer 111b subtracts the defeated of third absolute pressure transducer 111c Out, the intraocular pressure value of person monitored can be obtained.In addition, present embodiment can equally obtain two groups of intraocular pressures of person monitored in real time Data can judge the reliability of vivo sensing device when the consistency of this two groups of intraocular pressure data is bad according to error theory, Person monitored needs to contact doctor in time and calibrates intracorporal pressure sensor when occurring abnormal, so as to correct person's monitored Intraocular pressure data, or exclude the wrong intraocular pressure data of person monitored；For example, two pressure sensings in the monitoring unit 110 The average value for the intraocular pressure data that device detects is MmmHg, if the intraocular pressure that any pressure sensor detects in monitoring unit 110 Difference > d mmHg of data n and average value M, wherein d is preset deviation, preferably d >=0.1, then illustrates intracorporal pressure at this time The reliability of force snesor has to be tested, and person monitored needs to contact doctor in time and calibrates intracorporal pressure sensor, thus The intraocular pressure data of person monitored can be corrected, or exclude the wrong intraocular pressure data of person monitored；If any in monitoring unit 110 Difference≤dmmHg of intraocular pressure data n and average value M that pressure sensor detects, then illustrate that vivo sensing device can work normally, Intraocular pressure is the average value of pressure data.
1.3 internal body portions arrange at least one pressure sensor, an acceleration transducer and a gyro sensor
In another example as shown in figure 5, pressure sensor 111a is for detecting intraocular pressure, acceleration transducer 113a and gyroscope Sensor 114a is then respectively used to detect the acceleration and position of person's body monitored, then, when monitoring unit 110 includes simultaneously It is when pressure sensor 111a, acceleration transducer 113a and gyro sensor 114a, then right by host computer processing unit 220 The information of these sensors merges, and can effectively detect intraocular pressure data of the person monitored under various acceleration, angular speed, from And the influence of position, the motion state etc. of person monitored to intraocular pressure is assessed by doctor, in order to be mentioned in the case where intraocular pressure exception The person monitored that wakes up evades some dangerous plays and/or undesirable movement, living habit.In an alternate embodiment, it is supervised to reduce The volume and integrated difficulty for surveying unit 110, acceleration transducer 113a and gyro sensor 114a can be mounted on for example On the outer bodies such as signal relay unit 210.
Preferably, pass through near field communication technology (NFC) between the monitoring unit 110 and the signal relay unit 210 It is attached.Preferably, the signal relay unit 210 is suitable for being worn on head, chest and/or the four limbs of person monitored, example Glasses, eyeshade, cap form can be such as used, as long as can guarantee it and be implanted between intraocular monitoring unit 110 can It is communicated by ground, that is, the two should be as close to.
Preferably, pass through wired or wireless side between the signal relay unit 210 and the host computer processing unit 220 Formula is attached.
Preferably, as shown in Fig. 2, each sensor constitutes the modules of the signal collection of monitoring unit 110, for examining The parameters such as pressure, temperature, acceleration, angular speed are surveyed, and the parameter detected is converted into corresponding electric signal.Such as Fig. 1 Shown, in addition to monitoring unit 110, the intraocular part further includes signal conditioning unit 120, wireless communication unit 130 and the energy It receives and feed unit 140.Wherein, signal conditioning unit 120 includes filter circuit and amplifying circuit, and monitoring unit 110 will be electric Signal is transferred to the signal conditioning module 120 and is improved, and passes sequentially through filter circuit in the signal conditioning unit 120 After being filtered, being amplified by the amplifying circuit, reject signal in high frequency and mid-frequency noise, and by signal adjust to The scope of application of wireless communication unit 130, the wireless communication unit 130 can by signal wirelessly (such as NFC) it is transferred to the signal relay unit 210 of the outer body.
Preferably, as shown in fig. 6, the signal relay unit 210 include power module 211, power management module 212, Signal receiving module 213 and signal transmission module 214.These modules can be integrated on one piece of circuit board.Wherein, the signal connects The signal that module 213 is used to receive the transmission of wireless communication unit 140 is received, and the signal received is transmitted to the signal and is transmitted Module 214, preferably with SPI or I2The mode of C is transmitted.After the signal transmission module 214 receives signal, preferably pass through One of BLE, WiFi, ZigBee, 3G, 4G communication mode are communicated with the host computer processing unit 220, by signal It is wirelessly sent to the host computer processing unit 220.Alternatively, signal transmission module 214 can be replaced wire transmission module, from And it is communicated in a manner of wire communication with host computer processing unit 220.
The signal relay unit 210 is powered by the power module 211, and the power module 211 is preferably 3.7V Lithium battery, and different voltages needed for disparate modules then provide 212 by power management module.
Preferably, the monitoring unit 110 is powered by the signal relay unit 210.Specifically, the energy receive and Feed unit 140 has the first coupling coil, and the NFC signal receiving module has the second coupling coil, first coupling After coil is coupled with second coupling coil, the signal receiving module 213 can be received to the energy and feed unit 140 transmitting frequency electromagnetic waves, the energy receives and feed unit 140 receives the frequency electromagnetic waves, can be by the height The energy of frequency electromagnetic waves is converted to direct current, thus for the modules power supply in the monitoring unit 110.
Preferably, the host computer processing unit 220 can be the portable mobile termianl carried convenient for person monitored, example It such as can be the general communicating terminal of smart phone or other special equipments such as computer, recorder etc..
Preferably, as shown in Figure 1, system for monitoring intraocular pressure of the invention further includes cloud processing unit 230, the host computer Processing unit 220 can be communicated with the cloud processing unit 230, the data that will analyze that treated and/or without place The data of reason are transmitted to the cloud processing unit 230, and the cloud processing unit 230 can be docked using information fusion technology The data received are analyzed again, and analysis result is fed back to the host computer processing unit 220.Then, host computer is handled It can be that person monitored mentions according to the content of feedback information after unit 220 receives the feedback information of the cloud unit 230 For timely, effective information guiding.For example, the cloud processing unit 230 can calculate the eyes of person monitored beyond the clouds State, so as to be accustomed to by data prompts person's adjustment monitored, control with eye.
That is, when system for monitoring intraocular pressure of the invention includes cloud processing unit 230, for FUSION WITH MULTISENSOR DETECTION data Fusion treatment and analysis work can both be completed by host computer processing unit 220, can also be complete by cloud processing unit 230 At can also be completed jointly (both i.e. respectively to complete a part of data by host computer processing unit 220 and cloud processing unit 230 Handle work).
Preferably, setting has the APP software of BLE receive capabilities on the host computer processing unit 220, and has more Sensor data fusion function and network layer communication function, person monitored can be acquired by APP software control monitoring unit 110 Corresponding signal, and choose whether for data to be packaged and be uploaded to cloud processing unit 230, cloud processing unit 230 is calculated After corresponding data, person monitored can also choose whether to upload data according to the option of APP software shared.
Preferably, as shown in figure 5, the monitoring unit 110 of the internal body portion includes a pressure sensor 111a, one An acceleration transducer 113a and gyro sensor 114a, wherein pressure sensor 111a can be by the intraocular pressure of person monitored Parameter is converted into corresponding electric signal, and acceleration transducer 113a can convert the acceleration parameter of person's body monitored to accordingly Electric signal, gyro sensor 114a can convert corresponding electric signal for the angular speed parameter of person monitored.The energy It receives and feed unit 140 and the signal relay unit 210 connect (preferably close range wireless communication in such a way that coil couples (NFC) mode connects), the electric signal transmission that the signal relay unit 210 acquires the monitoring unit 110 is on described Position machine processing unit 220, what the host computer processing unit 220 acquired the monitoring unit 110 using information fusion technology Signal is handled, and thus can obtain the intraocular pressure under various acceleration, angular speed, i.e., the position of person monitored, movement in real time Influence of the information such as state to varieties of intraocular pressure.Particularly, when the position of person monitored, motion state are larger to intraocular pressure fluctuation generation When influence, for example, person monitored, within the period of 0.1~60s (preferably 1s), acceleration is 0.1~100m/s2(preferably 2m/ s2), angular speed be ± 0.1~1000 °/s (preferably 100 °/s) when, intraocular pressure fluctuation range be greater than 0.1~50mmHg (preferably 3mmHg), then optic nerve may be seriously damaged, the glaucoma state of an illness, then, host computer processing unit 220 are induced and/or aggravate Standby signal can be issued in time, to assess the influence to intraocular pressure such as position, motion state of person monitored by doctor, remind by Human observer evades some dangerous plays and bad life habits for causing intraocular pressure fluctuation range to rise violently.That is, intraocular pressure of the invention Monitoring system can not only accurate measurements person monitored intraocular pressure fluctuate situation, and can also distinguish cause intraocular pressure fluctuate one Divide reason, so that person monitored be reminded to evade certain dangerous plays and bad life habits in time.
1.4 internal body portions arrange three pressure sensors perpendicular to one another
Preferably, monitoring unit 110 can be implanted into the anterior chamber of examined person, as shown in fig. 7, the monitoring unit 110 Including three pressure sensors 111a, 111b and 111c, three pressure sensors be arranged in three of monitoring unit 110 that On this vertical side, that is, the measurement direction of three pressure sensors is perpendicular to one another, it is respectively facing three of space coordinates Direction.Wherein, each of three pressure sensors 111a, 111b and 111c can measure the direction of person monitored Intraocular pressure parameter, and it is translated into corresponding electric signal, the monitoring unit 110 and the signal relay unit 210 are with coil The mode of coupling connects (mode of preferably close range wireless communication (NFC) connects), and the signal relay unit 210 is by the prison The electric signal transmission of the acquisition of unit 110 is surveyed to host computer processing unit 220, the host computer processing unit 220 is melted using information The signal that conjunction technology acquires the monitoring unit 110 is handled, and thus can obtain three directions of person monitored in real time On intraocular pressure data, and can based on the intraocular pressure dynamic change on three directions of intraocular pressure data real-time monitoring on three directions, To assess influence of the Dynamic intraocular pressure to glaucoma.For example, the intraocular pressure data in three, a certain moment space direction are respectively G MmHg, HmmHg and L mmHg, and G > H > L then show that person monitored is now in motion state, while can assess person monitored Intraocular pressure fluctuate situation.
Specifically, intraocular pressure when being static due to the practical intraocular pressure of person monitored and movement the sum of bring dynamic pressure, In present embodiment, when person monitored is static and each pressure sensor is normal, the intraocular pressure data in three, space direction are answered Meet G=H=L, it is different to be diagnosed as intraocular pressure in this case, when if meeting any situation in following three kinds of conditions It is normal:
(1) intraocular pressure is more than a millimetres of mercury,
(2) eyes pressure difference is greater than b millimetres of mercury,
(3) t1 hours intraocular pressure differences are more than c millimetres of mercury；
Wherein, t1=1~100, a=3~80, b=3~10, c=3~30.
And when person monitored movement, then be likely to occur the unequal situation of intraocular pressure data in three, space direction, i.e. G ≠ H ≠ L, such bring intraocular pressure fluctuation is equally possible to oppress optic nerve and induce or aggravate glaucoma, in this case, such as Fruit fluctuation range of any of the intraocular pressure data in three, space direction in the first predetermined time t1 meets or exceeds first Predetermined amount a, then it is considered that intraocular pressure is abnormal；And when person monitored is static, if there is the intraocular pressure number in three, space direction According to unequal situation, i.e. G ≠ H ≠ L, then explanation has pressure sensor failure, and person monitored need to contact doctor and re-scale body Interior pressure sensor.As it can be seen that system for monitoring intraocular pressure of the invention can not only accurate measurements person monitored intraocular pressure fluctuate situation, And can also distinguish cause intraocular pressure fluctuate a part of reason, thus remind in time person monitored evade certain dangerous plays and Bad life habits.
In present embodiment, when the host computer processing unit 220 issues standby signal, it is preferable that can also give simultaneously The information of relationship between the intraocular pressure data in three, space direction out, person monitored itself can be then according to the information and combination It is no to be kept in motion to judge, to distinguish intraocular pressure exception or pressure sensor failure.
1.5 internal body portions arrange a pressure sensor and a temperature sensor
For example, temperature sensor 112a is for detecting in vivo as shown in figure 8, pressure sensor 111a is for detecting intraocular pressure Temperature, then, when monitoring unit 110 includes simultaneously pressure sensor 111a and temperature sensor 112a, at host computer It manages unit 220 to merge the information of these sensors, the body temperature that on the one hand can effectively monitor person monitored changes to eye The influence of pressure, for example, person monitored have a fever when the case where；On the other hand the temperature drift of pressure sensor 111a can also be corrected It moves, to improve monitoring accuracy.
The monitoring unit 110 of the internal body portion includes an a pressure sensor 111a and temperature sensor 112a, Wherein, the pressure sensor 111a can convert corresponding electric signal, the temperature sensing for the intraocular pressure parameter of person monitored Device 112a can convert the intracorporal temperature parameter of person monitored to corresponding electric signal, and the energy receives and feed unit 140 It connect and (is preferably connected in the way of close range wireless communication (NFC)) in a manner of coil coupling with the signal relay unit 210, The electric signal transmission that the signal relay unit 210 acquires the monitoring unit 110 to the host computer processing unit 220, The host computer processing unit 220 is handled using the signal that information fusion technology acquires the monitoring unit 110, thus The intraocular pressure and body temperature of person monitored can be obtained in real time.Pressure sensor 111a in vivo is produced with internal temperature change When the error of raw temperature drift, the body temperature that host computer processing unit 220 can be measured by temperature sensor 112a, to internal Pressure sensor 111a generate temperature drift with internal temperature change and be modified, for example, the temperature of pressure sensor 111a Degree drift is A mmHg/ DEG C, and body temperature rises B DEG C, and the pressure value of the display of pressure sensor 111a is CmmHg at this time, The correction value for the pressure value that then pressure sensor 111a is measured is (C-AB) mmHg.In the pressure measured to pressure sensor 111a Judge whether intraocular pressure is abnormal after value amendment again, so that the monitoring accuracy of system for monitoring intraocular pressure of the invention is improved.
1.6 internal body portions arrange six pressure sensors
Preferably, as shown in figure 9, the monitoring unit 110 include six pressure sensor 111a, 111b, 111c, 111d, 111e and 111f, six pressure sensors are that one group of three for being arranged in monitoring unit 110 is perpendicular to one another two-by-two On side, that is, first group of pressure sensor 111a and 111b are arranged in side by side in the first side of monitoring unit 110, the Two groups of pressure sensors 111c and 111d are arranged in side by side in the second side of monitoring unit 110, third group pressure sensor 111e and 111f is arranged in side by side on the third side of monitoring unit 110, and the normal direction of these three sides is respectively facing space seat Three directions of system are marked, the measurement direction of three groups of pressure sensors is also just perpendicular to one another, is respectively facing three of space coordinates Direction.Wherein, each of six pressure sensors 111a, 111b, 111c, 111d, 111e and 111f can measure and supervised The intraocular pressure parameter in the direction of survey person, and it is translated into corresponding electric signal, in the monitoring unit 110 and the signal Turn unit 210 to connect and (preferably connect in the way of close range wireless communication (NFC)) in a manner of coil coupling, the signal transfer For the electric signal transmission that unit 210 acquires the monitoring unit 110 to host computer processing unit 220, the host computer processing is single Member 220 is handled using the signal that information fusion technology acquires the monitoring unit 110, thus can three sides of real-time monitoring Upward intraocular pressure dynamic change to assess influence of the Dynamic intraocular pressure to glaucoma, while can assess the intraocular pressure wave of person monitored Emotionally condition.
Alternatively, six pressure sensors 111a, 111b, 111c, 111d, 111e and 111f can be arranged in monitoring On six different sides of unit 110, the normal direction of this six different sides is respectively facing three coordinates of space coordinates The positive direction and negative direction of axis, therefore, the measurement direction of six pressure sensors are also respectively facing three seats of space coordinates The positive direction and negative direction of parameter, thus the monitoring unit 110 can obtain the intraocular pressure value on six direction, can equally comment Estimate influence of the Dynamic intraocular pressure to glaucoma, while the intraocular pressure fluctuation situation of person monitored can be assessed.
Specifically, intraocular pressure when being static due to the practical intraocular pressure of person monitored and movement the sum of bring dynamic pressure, In above-mentioned two embodiment, for example, a certain moment six pressure sensors 111a, 111b, 111c, 111d, 111e and 111f The intraocular pressure data measured are respectively a1mmHg, a2mmHg, b1mmHg, b2mmHg, c1mmHg and c2mmHg, when person monitored is quiet When only and each pressure sensor is normal, the intraocular pressure data that six pressure sensors measure should meet a1=a2=b1=b2 =c1=c2, in this case, if it is different to be diagnosed as intraocular pressure when meeting any situation in following three kinds of conditions It is normal:
(1) intraocular pressure is more than a millimetres of mercury,
(2) eyes pressure difference is greater than b millimetres of mercury,
(3) t1 hours intraocular pressure differences are more than c millimetres of mercury；
Wherein, t1=1~100, a=3~80, b=3~10, c=3~30.
If a1=a2 > b1=b2 > c1=c2, show that person monitored is now in motion state, intraocular pressure is with movement feelings Condition and fluctuate, this fluctuation can equally oppress optic nerve and induce or aggravate glaucoma, in this case, if according with Intraocular pressure exception can be diagnosed as when closing any situation in following three kinds of conditions:
(1) intraocular pressure is more than a millimetres of mercury,
(2) eyes pressure difference is greater than b millimetres of mercury,
(3) t1 hours intraocular pressure differences are more than c millimetres of mercury；
Wherein, t1=1~100, a=3~80, b=3~10, c=3~30.
When the consistency for two groups of intraocular pressure data that unidirectional two pressure sensors measure when space is bad, for example, When a certain person monitored is static, two groups of intraocular pressure data that first group of pressure sensor 111a and 111b are measured be respectively a1mmHg and A2mmHg, and a1 > a2 then illustrate that the consistency of first group of pressure sensor 111a and 111b at this time go wrong, in the two extremely One reliability has to be tested less, and person monitored needs to contact doctor in time and calibrates intracorporal pressure sensor, Ji Kexiu The intraocular pressure data of person just monitored, or the wrong intraocular pressure data of person monitored are excluded, it thus can further improve intraocular pressure monitoring The reliability and precision of system.As it can be seen that system for monitoring intraocular pressure of the invention can not only accurate measurements person monitored intraocular pressure fluctuation Situation, and a part of reason for causing intraocular pressure to fluctuate can also be distinguished, so that person monitored be reminded to evade certain danger in time Movement and bad life habits.
1.7 internal body portions arrange three pressure sensors, an acceleration transducer and a gyro sensor
Preferably, as shown in Figure 10, the monitoring unit 110 includes three pressure sensor 111a, 111b and 111c, and three A pressure sensor is arranged on three sides perpendicular to one another of monitoring unit 110, that is, three pressure sensors Measurement direction is perpendicular to one another, is respectively facing three directions of space coordinates；Meanwhile the monitoring unit 110 further includes one An acceleration transducer 113a and gyro sensor 114a, wherein the acceleration transducer 113a and gyro sensors Device 114a is arranged on one of three sides above-mentioned, such as on the same side with pressure sensor 111a arrangement.It is each Pressure sensor 111a, 111b and 111c can convert corresponding electric signal, acceleration sensing for the intraocular pressure parameter of person monitored Device 113a can convert the acceleration parameter of person's body monitored to corresponding electric signal, and gyro sensor 114a can will be supervised The angular speed parameter of survey person is converted into corresponding electric signal.The monitoring unit 110 and the signal relay unit 210 are with coil The mode of coupling connects (mode of preferably close range wireless communication (NFC) connects), and the signal relay unit 210 is by the prison The electric signal transmission of the acquisition of unit 110 is surveyed to the host computer processing unit 220, the host computer processing unit 220 utilizes letter The signal that breath integration technology acquires the monitoring unit 110 is handled, and thus can obtain various acceleration, angle speed in real time Intraocular pressure under degree, i.e., influence of the information such as position, motion state of person monitored to varieties of intraocular pressure.As it can be seen that intraocular pressure of the invention Monitoring system can not only accurate measurements person monitored intraocular pressure fluctuate situation, and can also distinguish cause intraocular pressure fluctuate one Divide reason, so that person monitored be reminded to evade certain dangerous plays and bad life habits in time.
1.8 internal body portions arrange a pressure sensor, a heart rate sensor and a blood glucose sensor
Preferably, as shown in figure 11, the monitoring unit 110 includes a pressure sensor 111a, a sensing heart rate A device 116a and blood glucose sensor 117a.Wherein, pressure sensor 111a can convert phase for the intraocular pressure parameter of person monitored The electric signal answered, heart rate sensor 116a can convert the hrv parameter of person's body monitored to corresponding electric signal, and blood glucose passes Sensor 117a can convert corresponding electric signal for the glycemic parameters of person monitored.In the monitoring unit 110 and the signal Turn unit 210 to connect and (preferably connect in the way of close range wireless communication (NFC)) in a manner of coil coupling, the signal transfer The electric signal transmission that unit 210 acquires the monitoring unit 110 is to the host computer processing unit 220, at the host computer Reason unit 220 is handled using the signal that information fusion technology acquires the monitoring unit 110, thus can be obtained in real time Intraocular pressure under various hearts rate, blood glucose, i.e., influence of the information such as position, motion state of person monitored to varieties of intraocular pressure.As it can be seen that this The system for monitoring intraocular pressure of invention can not only the intraocular pressure of accurate measurements person monitored fluctuate situation, and can also distinguish and cause intraocular pressure A part of reason of fluctuation, so that person monitored be reminded to evade certain dangerous plays and bad life habits in time.
The collocation mode of a and a variety of drainage tubes more than 2. (or drainage nail)
In system for monitoring intraocular pressure of the invention, the type and quantity of drainage tube (or drainage nail), which can according to need, is taken Match, to obtain different monitoring effects, embodiment is as follows:
The monitoring system of 2.1 real-time monitoring intraocular pressures and intracranial pressure
Wang Ning benefit seminar finds that normal-pressure glaucoma patient's intracranial pressure is relatively low by perspective study for the first time, intraocular hypertension Disease patient's intracranial pressure is higher.Sieve is then confirmed in the checking research of Clinical controlled trial, Research of Animal Model for Study and general population Pressure difference increases between intraocular pressure and intracranial pressure before and after plate, results in Deterioration of Optic Nerve in Glaucoma.However, in the prior art Monitoring system can not monitor intraocular pressure and intracranial pressure simultaneously, and therefore, the present invention provides one kind, and intraocular pressure and encephalic can be monitored in real time The monitoring system of pressure.
The system is as shown in Figure 1, include internal body portion 100 and outer body 200, wherein internal body portion 100 includes prison It surveys unit 110, signal conditioning unit 120, wireless communication unit 130 and energy reception and feed unit 140, outer body includes Signal relay unit 210, host computer processing unit 220, cloud processing unit 230.The monitoring unit 110 is as shown in figure 12, It can plant the internal of person monitored (such as glaucoma patient), wherein intraocular pressure monitoring modular 111 and monitoring intracranial pressure module 115 are divided Not Tong Guo (preferably anterior chamber) in 150 insertion eyeball of drainage tube (or drainage nail), in 152 insertion cranial cavity of drainage tube (or drainage nail) (the preferably ventricles of the brain), so as to detect the intraocular pressure and intracranial pressure of person monitored respectively.And it will test data and pass through signal conditioning unit 120 processing, are sent to the signal relay unit 210 by wireless communication unit 130 later.Wherein, the monitoring unit 110 wraps At least one intraocular pressure monitoring modular 111 and a monitoring intracranial pressure module 115 are included, the intraocular pressure monitoring modular 111 includes at least One pressure sensor 111a；And/or the monitoring intracranial pressure module 115 includes at least one pressure sensor 115a；It is described Signal relay unit 210 is used to the data from the monitoring unit 110 being sent to the host computer processing unit 220；Institute Host computer processing unit 220 is stated for analyzing using detection data of the information fusion technology to the different sensors received Processing, and standby signal is issued when processing result shows intraocular pressure or/and intracranial pressure exception.
Intraocular pressure or/and monitoring intracranial pressure system of the invention can accurately be detected monitored by monitoring unit 110 The intraocular pressure or/and intracranial pressure data of person, and by host computer processing unit 220 to the information of multiple sensors carry out fusion treatment and Analysis, so that the reliability and measurement accuracy of intraocular pressure or/and monitoring intracranial pressure can be improved, and can show intraocular pressure in detection data Or/and in the case where intracranial pressure exception, standby signal is issued in time, prompt person monitored to take measures as early as possible, to avoid view Nerve damage meets the needs of such as glaucoma patient is real-time to ocular environment or/and encephalic environment, easily monitors.
2.2 use the system for monitoring intraocular pressure of two and two or more drainage tubes
The system is as shown in Figure 1, include internal body portion 100 and outer body 200, wherein internal body portion 100 includes prison Survey unit 110, signal conditioning unit 120, wireless communication unit 130 and energy reception and feed unit 140, outer body 200 Including signal relay unit 210, host computer processing unit 220, cloud processing unit 230.The monitoring unit 110 such as Figure 13 institute Show, can plant the internal of person monitored (such as glaucoma patient), wherein intraocular pressure monitoring modular 111 passes through two and two or more The insertion eyeball such as drainage tube 150a, 150b, 150c in (preferably anterior chamber), to can detect the intraocular pressure of person monitored, and reduce The probability of the blocking of monitoring unit 110 and failure.It is handled in addition, will test data by signal conditioning unit 120, later by wireless Communication unit 130 is sent to the signal relay unit 210.Wherein, the monitoring unit 110 is monitored including at least one intraocular pressure Module 111, the intraocular pressure monitoring modular 111 include at least one pressure sensor 111a；The signal relay unit 210 is used for Data from the monitoring unit 110 are sent to the host computer processing unit 220；The host computer processing unit 220 For being analyzed and processed using detection data of the information fusion technology to the different sensors received, and in processing result table Standby signal is issued when bright intraocular pressure exception.
System for monitoring intraocular pressure of the invention can be combined by the drainage tube of monitoring unit 110 and two and two or more, The intraocular pressure data for accurately detecting person monitored, when a wherein blocked drainage tube, other drainage tubes can also normally draw Stream, to improve the working life and reliability of system for monitoring intraocular pressure.
2.3 use the system for monitoring intraocular pressure of the drainage tube of two or more branches
The system is as shown in Figure 1, include internal body portion 100 and outer body 200, wherein internal body portion 100 includes prison Survey unit 110, signal conditioning unit 120, wireless communication unit 130 and energy reception and feed unit 140, outer body 200 Including signal relay unit 210, host computer processing unit 220, cloud processing unit 230.The monitoring unit 110 such as Figure 14 institute Show, can plant the internal of person monitored (such as glaucoma patient), wherein intraocular pressure monitoring modular 111 uses two or more The drainage tube 151 of branch is inserted into eyeball (preferably anterior chamber), to can detect the intraocular pressure of person monitored, and reduces monitoring unit The probability of 110 blockings and failure.In addition, will test data by signal conditioning unit processing 120, later by wireless communication unit 130 are sent to the signal relay unit 210.Wherein, the monitoring unit 110 includes at least one intraocular pressure monitoring modular 111, The intraocular pressure monitoring modular 111 includes two or more pressure sensor 111a；The signal relay unit 210 is used for Data from the monitoring unit 110 are sent to the host computer processing unit 220；The host computer processing unit 220 For being analyzed and processed using detection data of the information fusion technology to the different sensors received, and in processing result table Standby signal is issued when bright intraocular pressure exception.
System for monitoring intraocular pressure of the invention can accurately detect the intraocular pressure number of person monitored by monitoring unit 110 According to, when the wherein blocked drainage tube of a branch, the drainage tubes of other branches can also normal drainage, to improve intraocular pressure monitoring system The working life and reliability of system.In addition to this, compared to the system for monitoring intraocular pressure of the drainage tube using two and two or more Drainage way, the drainage way of this branch reduces the drainage tube number of insertion anterior chamber, therefore can reduce person's monitored Damage.
Particularly, multiple sensors in system for monitoring intraocular pressure can be installed one by one by single sensor and be formed, can also be with It is made into a chip (device) by way of Integrated manufacture, to reduce volume, improves reliability.
On the basis of above-mentioned work, the second aspect of the present invention provides a kind of intraocular pressure monitoring method, uses this hair Bright mentioned-above system for monitoring intraocular pressure, and preferably as shown in figure 15, comprising steps of
S10, the internal body portion monitor the intraocular pressure of person monitored, and pressure signal is converted into electric signal；
Monitoring data are sent to the signal relay unit 210 by S20, the internal body portion；
Data from the monitoring unit 110 are sent at the host computer by S30, the signal relay unit 210 Manage unit 220；
S40, the host computer processing unit 220 are analyzed and processed the data received using information fusion technology；
S50, the host computer processing unit 220 pass through certain algorithm according to the data of two or more pressure sensors Whether comprehensive descision intraocular pressure is abnormal, and issues standby signal when being confirmed as intraocular pressure exception.
Preferably, the multiple groups intraocular pressure data that two or more pressure sensors in the monitoring unit detect Judge the reliability of vivo sensing device according to error theory, person monitored needs to contact doctor school in time when occurring abnormal Quasi- intracorporal pressure sensor so as to correct the intraocular pressure data of person monitored, or excludes the wrong intraocular pressure number of person monitored According to；In the present embodiment, it is preferable that the eye that two or more pressure sensors in the monitoring unit 110 detect The average value for pressing data is MmmHg, if the intraocular pressure data n that any pressure sensor detects in monitoring unit 110 and average Difference > dmmHg of value M, wherein d is preset deviation, preferred d >=0.1, then illustrate intracorporal pressure sensor at this time can Have by property to be tested, person monitored needs to contact doctor in time and calibrates intracorporal pressure sensor, monitored so as to correct The intraocular pressure data of person, or exclude the wrong intraocular pressure data of person monitored；D < 0.1 then illustrates that vivo sensing device can work normally, Intraocular pressure is the average value of pressure data；
Preferably, the multiple groups intraocular pressure data that two or more pressure sensors in the monitoring unit detect The measurement accuracy of internal pressure sensor is improved according to multisensor Weighted Fusion algorithm, it can be according to each pressure sensor Measurement variance determines the weighting coefficient of each pressure sensor, finally merges out intraocular pressure data；In the present embodiment, it is preferable that The measurement equation expression formula of the monitoring unit 110 are as follows:
Y=Hx+e
In formula, x is quantity of state to be measured, Y=[y1y2y3···yn]TMeasurement vector, e=[e are tieed up for n1e2e3···en ]TMeasurement noise vector is tieed up for n, wherein eiMutually indepedent and satisfactionWherein i=1,2 ..., n；For each signal The variance in source；H is that known n × 1 ties up calculation matrix, H=[1 ... 1]T。
Under the principle of linear minimum-variance estimation, partial combination assessing value are as follows:
Wherein weighting coefficient calculation formula are as follows:
Weighted Fusion error is mean square error, and concrete form is as follows:
According to the important conclusion of the available Weighted Fusion of above-mentioned formula: poor sensor participates in Weighted Fusion all to precision again The precision of fusion results can be improved.In addition, Weighted Fusion precision is practical to depend on the accurate of sensor measurement Noise Variance Estimation Property.
In the present embodiment, it is preferable that two pressure sensors 111a and 111b of the use in the monitoring unit 110 are examined The measurement result of the intraocular pressure data measured is respectively MmmHg and NmmHg, can have been determined by the measurement variance of two pressure sensors Its corresponding weighting coefficient is K and L, then intraocular pressure data can be fused to
Preferably, the multiple groups intraocular pressure data that two or more pressure sensors in the monitoring unit detect The measurement accuracy of internal pressure sensor is improved according to multisensor estimation fusion algorithm, it can be according to the measurement of each sensor Data establish corresponding, iteration model, the estimated value and actual measured value that the model calculates are taken weighted average, most After merge out intraocular pressure data；In the present embodiment, it is preferable that two pressure sensors of the use in the monitoring unit 110 The measurement result for the intraocular pressure data that 111a and 111b are detected is respectively MmmHg and NmmHg, wherein by the pressure sensor Data before 111a can obtain model x (a), estimated value PmmHg can be obtained by model x (a), before the 111b by pressure sensor Data can obtain model y (b), estimated value Q mmHg can be obtained by model y (b), by the test variance of the pressure sensor model The weighting coefficient that can determine pressure sensor 111a model is K, and the weighting coefficient of pressure sensor 111b model is L, then intraocular pressure Data can be fused to
Preferably, the multiple groups intraocular pressure data that two or more pressure sensors in the monitoring unit detect The measurement accuracy of internal pressure sensor is improved according to machine learning method, it is two or more in the monitoring unit Model structure (preferably linear regression, logistic regression, a Bayes may be selected in the multiple groups intraocular pressure data that pressure sensor detects Model, decision tree), training data input model is used later, then optimal models structure is analyzed by learning algorithm, described in most The estimated value and actual measured value that excellent model structure is calculated take weighted average, finally merge out intraocular pressure data；The present embodiment In, it is preferable that the intraocular pressure data that two pressure sensors 111a and 111b of the use in the monitoring unit 110 are detected Measurement result is respectively MmmHg and NmmHg, wherein the pressure sensor 111a selects an existing model structure (preferably Linear regression, logistic regression, Bayesian model, decision tree etc.), the test data input model before using later, then pass through It practises algorithm and analyzes optimal models structure x (a), estimated value P mmHg can be obtained by model x (a), similarly the pressure sensor 111b selects a model structure (preferably linear regression, logistic regression, Bayesian model, decision tree etc.), before using later Test data input model, then optimal models structure y (b) is analyzed by learning algorithm, estimated value Q can be obtained by model y (b) MmHg can determine that the weighting coefficient of pressure sensor 111a model is K, pressure by the test variance of the pressure sensor model The weighting coefficient of sensor 111b model is L, then intraocular pressure data can be fused to
Preferably, in step S50, the host computer processing unit 220 judges the fluctuation situation of intraocular pressure, and following meeting Intraocular pressure exception can be diagnosed as when one of three kinds of conditions situation:
(1) intraocular pressure is more than a millimetres of mercury,
(2) eyes pressure difference is greater than b millimetres of mercury,
(3) t1 hours intraocular pressure differences are more than c millimetres of mercury.
In the present embodiment, it is preferable that t1=1~100, and/or, a=3~80, and/or, b=3~10, and/or, c=3 ~30.That is, within the predetermined time, such as within any 1 hour or 24 hours time, if host computer processing unit 220 judge that the fluctuation range of intraocular pressure reaches 8mmHg, it may be considered that intraocular pressure is abnormal, and issue standby signal immediately.Then, by After human observer knows the standby signal, it can take appropriate measures, further deteriorate to avoid rough sledding.
Preferably, the monitoring unit 110 or the signal relay unit 210 include at least one acceleration transducer 113a and/or at least one gyro sensor 114a, for example, as shown in figure 5, the monitoring unit 110 includes a pressure Sensor 111a, an acceleration transducer 113a and a gyro sensor 114a.In this case, in step S50, institute Host computer processing unit 220 is stated according to the data of two or more pressure sensors, is sentenced by certain algorithm synthesis processing result The disconnected influence of acceleration and/or angular speed to intraocular pressure, and be more than pre- being confirmed as intraocular pressure with the fluctuation of acceleration and/or angular speed When fixed limit is spent, standby signal is issued.
Preferably, the monitoring unit 110 includes at least one pressure sensor 111a and at least one temperature sensor 112a, for example, as shown in Figure 8.In this case:
In step S10, the monitoring unit 110 also detects the body temperature of person monitored, and temperature signal is converted into Electric signal；
In step S50, the host computer processing unit 220 is judging that intraocular pressure whether before exception, first passes the pressure The temperature drift that sensor 111a is generated with internal temperature change is modified, and obtains revised pressure value, later according still further to Revised pressure value judges whether intraocular pressure is abnormal.For example, the temperature drift of pressure sensor 111a is when person monitored has a fever A mmHg/ DEG C, body temperature rise B DEG C, and the pressure value of the display of intracorporal pressure sensor 111a is CmmHg at this time, then The correction value for the pressure value that intracorporal pressure sensor 111a is measured is (C-AB) mmHg.
Judge whether intraocular pressure is abnormal again after the pressure value amendment measured to pressure sensor 111a, so that eye of the invention The monitoring accuracy of pressure monitoring method is improved.
Preferably, as shown in figure 3, the monitoring unit 110 includes two pressure sensor 111a being arranged in juxtaposition.It is this In the case of:
In step S10, the monitoring unit 110 detects person monitored using two pressure sensor 111a each independently Intraocular pressure, and pressure signal is converted into electric signal, obtains two groups of intraocular pressure data；
In step S40, the host computer processing unit 220 analyzes the data received using information fusion technology Processing, and judge the consistency of two groups of intraocular pressure data, for example, calculating | E-F | whether > d mmHg is true；
In step S50, when | E-F | when > dmmHg is set up, the capable of emitting intraocular pressure data of the host computer processing unit 220 are different The standby signal of cause；When | E-F | when > dmmHg is invalid, the host computer processing unit 220 judges whether intraocular pressure is abnormal, and It is confirmed as issuing standby signal when intraocular pressure exception.
Preferably, the system for monitoring intraocular pressure includes cloud processing unit 230；As shown in figure 16, step S50 is further wrapped Include step:
S510, the host computer processing unit 220 will analyze treated data and/or untreated data are transmitted to The cloud processing unit 230；
S520, the cloud processing unit 230 analyze the data received using information fusion technology again, and will Analysis result feeds back to the host computer processing unit 220；
Whether extremely S530, the host computer processing unit 220 judge intraocular pressure according to the feedback information received, and true Think to issue standby signal when intraocular pressure exception.
Using the powerful calculating ability of cloud processing unit 230, it can analyze, handle, inquiring more data, thus right The comprehensive and accuracy for improving analysis result is advantageous.
Those skilled in the art will readily recognize that above-mentioned each preferred embodiment can be free under the premise of not conflicting Ground combination, superposition.
It should be appreciated that above-mentioned embodiment is merely exemplary, and not restrictive, without departing from of the invention basic In the case where principle, those skilled in the art can be directed to the various apparent or equivalent modification or replace that above-mentioned details is made It changes, is all included in scope of the presently claimed invention.

Claims (15)

1. a kind of system for monitoring intraocular pressure, which is characterized in that including internal body portion and outer body, the internal body portion is for real-time Intraocular parameter is monitored, signal condition is carried out, sends and receives signal；The outer body is for wirelessly supplying internal body portion Can, and the data spread out of to internal body portion are received, information merges and processing；
Wherein, the internal body portion includes at least one monitoring unit, and the monitoring unit includes at least two sensors, described Sensor is for monitoring intraocular pressure parameter；
The outer body includes at least one multi-sensor information fusion module, by information fusion technology to the number received According to being analyzed and processed.
2. system for monitoring intraocular pressure according to claim 1, which is characterized in that
The monitoring unit includes the pressure sensor that at least one is used to monitor intraocular pressure.
3. system for monitoring intraocular pressure according to claim 2, which is characterized in that
The monitoring unit further includes at least one drainage tube, at least one pressure in the drainage tube and the monitoring unit Sensor connection；
The drainage tube is for being inserted into eyeball, so as to drain aqueous humor to monitoring unit.
4. system for monitoring intraocular pressure according to claim 1, which is characterized in that
The outer body includes at least one sensor.
5. system for monitoring intraocular pressure according to claim 4, which is characterized in that
The outer body includes at least one pressure sensor, for monitoring atmospheric pressure；
And/or the outer body includes at least one acceleration transducer and/or at least one gyro sensor, is used for The acceleration and/or angular speed for measuring and/or monitoring person's body monitored, enable the system for monitoring intraocular pressure to pass through monitoring The acceleration and/or angular speed and/or posture of person's body monitored improve the precision of tonometry；
And/or the outer body includes at least one temperature sensor, for measuring and/or monitoring person monitored and/or ring The temperature in border, so that the system for monitoring intraocular pressure is it can be considered that or exclude the influence that monitors to intraocular pressure of temperature change.
6. system for monitoring intraocular pressure according to claim 2, which is characterized in that
The monitoring unit includes at least one acceleration transducer and/or at least one gyro sensor, for monitor by The acceleration and/or angular speed on human observer head, enable the system for monitoring intraocular pressure to monitor acceleration and/or angular speed pair The influence of intraocular pressure；
And/or the monitoring unit includes at least one temperature sensor, for monitoring the body temperature of person monitored, so that The system for monitoring intraocular pressure can monitor influence of the body temperature variation to intraocular pressure.
7. system for monitoring intraocular pressure described in one of -6 according to claim 1, which is characterized in that
The outer body includes signal relay unit and host computer processing unit, and the signal relay unit is described for receiving The supplemental characteristic of internal body portion transmission, and the data received are reported to the host computer processing unit, it is described at least one Multi-sensor information fusion module is arranged in the host computer processing unit.
8. system for monitoring intraocular pressure according to claim 7, which is characterized in that
The outer body further includes cloud processing unit, the cloud processing unit can with the host computer processing unit into Row communication, to receive and store the supplemental characteristic from the host computer processing unit, and can utilize multi-sensor information Integration technology analyzes the data received again, and analysis result is fed back to the host computer processing unit.
9. system for monitoring intraocular pressure according to claim 7 or 8, which is characterized in that
The signal relay unit is suitable for being worn on head, chest, trunk and/or the four limbs of person monitored.
10. a kind of intraocular pressure monitoring method, which is characterized in that system for monitoring intraocular pressure described in one of -9 according to claim 1 is used, The outer body of the system for monitoring intraocular pressure includes signal relay unit and host computer processing unit；The intraocular pressure monitoring method packet Include step:
S10, the internal body portion monitor the intraocular pressure of person monitored, and pressure signal is converted into electric signal；
Monitoring data are sent to the signal relay unit by S20, the internal body portion；
Data from the internal body portion are sent to the host computer processing unit by S30, the signal relay unit；
S40, the host computer processing unit are analyzed and processed the data received using information fusion technology；
Whether extremely S50, the host computer processing unit judge intraocular pressure according to processing result, and intraocular pressure is provided when intraocular pressure is normal Information issues standby signal when confirming intraocular pressure exception.
11. intraocular pressure monitoring method according to claim 10, which is characterized in that the monitoring unit includes at least two pressures Force snesor；In step S50, the host computer processing unit passes through according to the data of two or more pressure sensors Data anastomosing algorithm comprehensive descision, the case where obtaining intraocular pressure and data.
12. intraocular pressure monitoring method according to claim 11, which is characterized in that in step S50, the host computer processing is single Member judges intraocular pressure situation, and intraocular pressure exception can be diagnosed as when meeting any situation in following three kinds of conditions:
(1) intraocular pressure is more than a millimetres of mercury,
(2) eyes pressure difference is greater than b millimetres of mercury,
(3) intraocular pressure difference is more than c millimetres of mercury in t1 hours.
Wherein, t1=1~100, a=3~80, b=3~10, c=3~30.
13. intraocular pressure monitoring method described in one of 0-12 according to claim 1, which is characterized in that the monitoring unit or institute Stating signal relay unit includes at least one acceleration transducer and/or at least one gyro sensor；In step S50, institute Host computer processing unit is stated to be corrected according to measurement result of the measurement result of acceleration and/or angular-rate sensor to intraocular pressure Or compensation, and when being confirmed as fluctuation of the intraocular pressure with acceleration and/or angular speed more than predetermined limits, issue standby signal.
14. intraocular pressure monitoring method described in one of 0-12 according to claim 1, which is characterized in that the monitoring unit includes extremely A few pressure sensor and at least one temperature sensor；
In step S10, the monitoring unit also monitors the body temperature of person monitored, and temperature signal is converted into electric signal；
In step S50, temperature that the host computer processing unit first generates the pressure sensor with internal temperature change Degree drift is modified, and obtains revised pressure value, judges whether intraocular pressure is abnormal according still further to revised pressure value later.
15. intraocular pressure monitoring method described in one of 0-14 according to claim 1, which is characterized in that the system for monitoring intraocular pressure packet Include cloud processing unit；Step S50 comprising steps of
S510, the host computer processing unit will analyze treated data and/or untreated data are transmitted to the cloud Hold processing unit；
S520, the cloud processing unit analyze the data received using information fusion technology again, and analysis is tied Fruit feeds back to the host computer processing unit；
Whether extremely S530, the host computer processing unit judge intraocular pressure according to the feedback information received, and are being confirmed as eye Standby signal is issued when reduce off-flavor is normal.
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