CN108976383A - A kind of Medical macromolecular splint - Google Patents
A kind of Medical macromolecular splint Download PDFInfo
- Publication number
- CN108976383A CN108976383A CN201810675266.4A CN201810675266A CN108976383A CN 108976383 A CN108976383 A CN 108976383A CN 201810675266 A CN201810675266 A CN 201810675266A CN 108976383 A CN108976383 A CN 108976383A
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- China
- Prior art keywords
- added
- necked flask
- weight
- parts
- dimethylformamide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
- C08G18/76—Polyisocyanates or polyisothiocyanates cyclic aromatic
- C08G18/7657—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings
- C08G18/7664—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups
- C08G18/7671—Polyisocyanates or polyisothiocyanates cyclic aromatic containing two or more aromatic rings containing alkylene polyphenyl groups containing only one alkylene bisphenyl group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
- C08G18/4238—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyurethanes Or Polyureas (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
The invention discloses a kind of Medical macromolecular splint, and specifically the production method is as follows step 1: methyl diphenylene diisocyanate being added in three-necked flask by measuring spoon, and n,N-Dimethylformamide is added；After step 1 is handled well, the three-necked flask of step 1 is passed through nitrogen, and be internally stirred, heat；Step 3: polyadipate second diester is sent by measuring spoon and is dissolved in n,N-Dimethylformamide, after being completely dissolved, is added into three-necked flask by constant pressure funnel, after being added completely into, is heated, the performed polymer of polyurethane is obtained；Step 4: by 1,4-butanediol and being dissolved in methyl diphenylene diisocyanate by measuring spoon, and mixed solution is added in step 3 treated three-necked flask, after being added dropwise, continues to heat, and is uniformly mixed system.
Description
Technical field
The invention belongs to field of medical technology, and in particular to a kind of Medical macromolecular splint.
Background technique
For existing Macromolecular splint mainly based on polyurethane, polycaprolactone glycol is additional to be added with other as block
Agent is added to form.
Patent CN02150720.1 discloses a kind of shape memory bone fixing splint, by shape memory high molecule material and
Thermo electric material is made, and skeletal fixation clamping plate softens and shrinks to pack tightly and fracturing or rectifying when being heated to transition temperature or more
Shape position, operation temperature are 45~75 DEG C, and clamping plate internal layer and the not set thermal insulation layer in skin contact position, temperature control change shape
Become extremely important, but the technology does not refer to the accuracy control method to temperature.CN200510020610.9 discloses a kind of antibacterial
Shape memory polyurethane Osteological, solid rehabilitation plate and preparation method thereof, which adds antibacterial by shape memory polyurethane
Agent and inorganic filler are prepared by heating pressurization, are not directed to its planform.Patent CN201610520027.2 is announced
A kind of shape memory medical splint, is made of temperature-controlling system and shape memory type high molecular material, can control its operation temperature,
But due to adding temperature control system, higher cost.
Summary of the invention
The purpose of the present invention is to provide a kind of Medical macromolecular splint, to solve mentioned above in the background art not have
There is the problem of good shape changes effect and higher cost.
To achieve the above object, the invention provides the following technical scheme: a kind of Medical macromolecular splint, by following weight at
The raw material divided is made: methyl diphenylene diisocyanate 8-12.5 parts by weight, 1,4-butanediol 1.5-2 parts by weight, N, N- diformazan
Base formamide 40-52 parts by weight, polyadipate second diester 28-33.5 parts by weight.
Specifically the production method is as follows:
Methyl diphenylene diisocyanate: being added in three-necked flask by measuring spoon, and N be added by step 1, N- dimethyl
Formamide.
Step 2: after step 1 is handled well, being passed through nitrogen for the three-necked flask of step 1, and is internally stirred, adds
Heat.
Step 3: being sent polyadipate second diester by measuring spoon and dissolved in n,N-Dimethylformamide, it is completely molten
Xie Hou is added into three-necked flask by constant pressure funnel, after being added completely into, is heated, and the pre-polymerization of polyurethane is obtained
Body.
Step 4: by 1,4-butanediol and being dissolved in methyl diphenylene diisocyanate by measuring spoon, and will be mixed
It closes solution to be added in step 3 treated three-necked flask, after being added dropwise, continues to heat, keep system mixing equal
It is even.
Step 5: after the reaction was completed to step 4, promoting its heating temperature value, is purified step everywhere by vacuum distillation
Polyurethane purification after reason.Finally with pouring into mold machine-shaping.
Further, the n,N-Dimethylformamide being added in the step 1 is 25-30 parts by weight, in the step 2
Heating temperature to three-necked flask is 60 DEG C.
Further, the molecular weight of the polyadipate second diester in the step 3 is 2000, and N, N- dimethyl formyl
Amine is 10-14 parts by weight, in the step 3 heating temperature of three-necked flask with 60 DEG C heating water bath 2 hours.
Further, the n,N-Dimethylformamide of the step 4 is 5-8 parts by weight, and three-necked flask is with 60 DEG C of water-baths
Temperature heats 1.5h.
Further, the heating temperature of the step 5 is promoted to 72 DEG C -77 DEG C.
Compared with prior art, the beneficial effects of the present invention are: tradition have shape memory function Macromolecular splint by
It is very low in glass transition temperature, it is easy to happen deformation when in use, when as fixed materials'use, cannot play well
Fixed function, current polyadipate fourth diester have good stationarity as soft segment, synthetic product, at normal temperature substantially not
Deformation occurs, and reachable 100% in shape recovery ratio 10s, reusable or recycling.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Medical macromolecular splint is made of the raw material of following weight item: 8 weight of methyl diphenylene diisocyanate
Part, 1.5 parts by weight of 1,4-butanediol, 40 parts by weight of n,N-Dimethylformamide, 28 parts by weight of polyadipate second diester.
Specifically the production method is as follows:
Methyl diphenylene diisocyanate: being added in three-necked flask by measuring spoon, and N be added by step 1, N- dimethyl
Formamide.
Step 2: after step 1 is handled well, being passed through nitrogen for the three-necked flask of step 1, and is internally stirred, adds
Heat.
Step 3: being sent polyadipate second diester by measuring spoon and dissolved in n,N-Dimethylformamide, it is completely molten
Xie Hou is added into three-necked flask by constant pressure funnel, after being added completely into, is heated, and the pre-polymerization of polyurethane is obtained
Body.
Step 4: by 1,4-butanediol and being dissolved in methyl diphenylene diisocyanate by measuring spoon, and will be mixed
It closes solution to be added in step 3 treated three-necked flask, after being added dropwise, continues to heat, keep system mixing equal
It is even.
Step 5: after the reaction was completed to step 4, promoting its heating temperature value, is purified step everywhere by vacuum distillation
Polyurethane purification after reason.Finally with pouring into mold machine-shaping.
Wherein, the n,N-Dimethylformamide being added in the step 1 is 25 parts by weight, to three mouthfuls in the step 2
The heating temperature of flask is 60 DEG C.
Wherein, the molecular weight of the polyadipate second diester in the step 3 is 2000, and n,N-Dimethylformamide is
10 parts by weight, in the step 3 heating temperature of three-necked flask with 60 DEG C heating water bath 2 hours.
Wherein, the n,N-Dimethylformamide of the step 4 is 5 parts by weight, and three-necked flask is added with 60 DEG C of bath temperatures
Hot 1.5h.
Wherein, the heating temperature of the step 5 is promoted to 72 DEG C.
Embodiment 2
A kind of Medical macromolecular splint is made of the raw material of following weight item: methyl diphenylene diisocyanate 12.5
Parts by weight, 2 parts by weight of 1,4-butanediol, 52 parts by weight of n,N-Dimethylformamide, 33.5 parts by weight of polyadipate second diester.
Specifically the production method is as follows:
Methyl diphenylene diisocyanate: being added in three-necked flask by measuring spoon, and N be added by step 1, N- dimethyl
Formamide.
Step 2: after step 1 is handled well, being passed through nitrogen for the three-necked flask of step 1, and is internally stirred, adds
Heat.
Step 3: being sent polyadipate second diester by measuring spoon and dissolved in n,N-Dimethylformamide, it is completely molten
Xie Hou is added into three-necked flask by constant pressure funnel, after being added completely into, is heated, and the pre-polymerization of polyurethane is obtained
Body.
Step 4: by 1,4-butanediol and being dissolved in methyl diphenylene diisocyanate by measuring spoon, and will be mixed
It closes solution to be added in step 3 treated three-necked flask, after being added dropwise, continues to heat, keep system mixing equal
It is even.
Step 5: after the reaction was completed to step 4, promoting its heating temperature value, is purified step everywhere by vacuum distillation
Polyurethane purification after reason.Finally with pouring into mold machine-shaping.
Wherein, the n,N-Dimethylformamide being added in the step 1 is 30 parts by weight, to three mouthfuls in the step 2
The heating temperature of flask is 60 DEG C.
Wherein, the molecular weight of the polyadipate second diester in the step 3 is 2000, and n,N-Dimethylformamide is
14 parts by weight, in the step 3 heating temperature of three-necked flask with 60 DEG C heating water bath 2 hours.
Wherein, the n,N-Dimethylformamide of the step 4 is 8 parts by weight, and three-necked flask is added with 60 DEG C of bath temperatures
Hot 1.5h.
Wherein, the heating temperature of the step 5 is promoted to 77 DEG C.
The working principle of the invention and process for using: Macromolecular splint being immersed in 40 DEG C or more of hot water and impregnate 1min,
Being applied while hot after taking-up makes its figuration in arm or leg corresponding position, is bandaged with gauze, is cooled to room to temperature
Material can be fixed on corresponding position after temperature, and at room temperature will not deformation occurs；Clamping plate installs；It will be by gauze when dismounting
It cuts off i.e. dismountable；Injury can be observed by X-ray at any time in use process, and clamping plate is adjusted by the above process
Or dressing.
Clamping plate after dismounting, which is heated to 70 DEG C, can be restored to original shape, after sterilized disinfection treatment, repeat
It uses.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. a kind of Medical macromolecular splint is made of the raw material of following weight item: methyl diphenylene diisocyanate 8-12.5
Parts by weight, 1,4-butanediol 1.5-2 parts by weight, n,N-Dimethylformamide 40-52 parts by weight, polyadipate second diester 28-
33.5 parts by weight.
Specifically the production method is as follows:
Methyl diphenylene diisocyanate: being added in three-necked flask by measuring spoon, and N be added by step 1, N- dimethyl formyl
Amine.
Step 2: after step 1 is handled well, the three-necked flask of step 1 is passed through nitrogen, and be internally stirred, heat.
Step 3: being sent polyadipate second diester by measuring spoon and dissolved in n,N-Dimethylformamide, after being completely dissolved,
It is added into three-necked flask by constant pressure funnel, after being added completely into, is heated, obtain the performed polymer of polyurethane.
Step 4: by 1,4-butanediol and being dissolved in methyl diphenylene diisocyanate by measuring spoon, and will be mixed molten
Liquid is added in step 3 treated three-necked flask, after being added dropwise, continues to heat, and is uniformly mixed system.
Step 5: after the reaction was completed to step 4, promoting its heating temperature value, after being handled step 4 by vacuum distillation purification
Polyurethane purification.Finally with pouring into mold machine-shaping.
2. a kind of Medical macromolecular splint according to claim 1, it is characterised in that: the N being added in the step 1, N-
Dimethylformamide is 25-30 parts by weight, is 60 DEG C to the heating temperature of three-necked flask in the step 2.
3. a kind of Medical macromolecular splint according to claim 1, it is characterised in that: the polyadipate in the step 3
The molecular weight of second diester is 2000, and n,N-Dimethylformamide is 10-14 parts by weight, and three-necked flask adds in the step 3
Hot temperature with 60 DEG C heating water bath 2 hours.
4. a kind of Medical macromolecular splint according to claim 1, it is characterised in that: the N of the step 4, N- dimethyl
Formamide is 5-8 parts by weight, and three-necked flask heats 1.5h with 60 DEG C of bath temperatures.
5. a kind of Medical macromolecular splint according to claim 1, it is characterised in that: the heating temperature of the step 5 mentions
Rise to 72 DEG C -77 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810675266.4A CN108976383A (en) | 2018-06-27 | 2018-06-27 | A kind of Medical macromolecular splint |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810675266.4A CN108976383A (en) | 2018-06-27 | 2018-06-27 | A kind of Medical macromolecular splint |
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| Publication Number | Publication Date |
|---|---|
| CN108976383A true CN108976383A (en) | 2018-12-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810675266.4A Pending CN108976383A (en) | 2018-06-27 | 2018-06-27 | A kind of Medical macromolecular splint |
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| Country | Link |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411262A (en) * | 1978-04-21 | 1983-10-25 | Bayer Aktiengesellschaft | Constructional material |
| CN1563132A (en) * | 2004-03-19 | 2005-01-12 | 中国科学院长春应用化学研究所 | Shape memory material based on poly(e-caprolactone), preparation and metod of application |
| CN1669590A (en) * | 2005-03-29 | 2005-09-21 | 四川大学 | Antibacterial shape memory polyurethane orthopedic, fixing and rehabillitative plate and preparation method thereof |
| CN1706998A (en) * | 2004-06-10 | 2005-12-14 | 香港理工大学 | Shape memory fiber and its prepn process |
| CN104387754A (en) * | 2014-11-26 | 2015-03-04 | 温州科保塑料科技有限公司 | Hot-melt medical splint material and production process thereof |
| CN107661543A (en) * | 2017-11-14 | 2018-02-06 | 安徽斯麦特医学技术开发有限公司 | A kind of processing method of the polyurethane resin performed polymer of Medical macromolecular splint production |
| CN108084394A (en) * | 2017-12-25 | 2018-05-29 | 青岛科技大学 | A kind of shape memory hard polyurethane foam medical splint material and preparation method thereof |
-
2018
- 2018-06-27 CN CN201810675266.4A patent/CN108976383A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411262A (en) * | 1978-04-21 | 1983-10-25 | Bayer Aktiengesellschaft | Constructional material |
| US4411262B1 (en) * | 1978-04-21 | 1985-07-16 | ||
| CN1563132A (en) * | 2004-03-19 | 2005-01-12 | 中国科学院长春应用化学研究所 | Shape memory material based on poly(e-caprolactone), preparation and metod of application |
| CN1706998A (en) * | 2004-06-10 | 2005-12-14 | 香港理工大学 | Shape memory fiber and its prepn process |
| CN1669590A (en) * | 2005-03-29 | 2005-09-21 | 四川大学 | Antibacterial shape memory polyurethane orthopedic, fixing and rehabillitative plate and preparation method thereof |
| CN104387754A (en) * | 2014-11-26 | 2015-03-04 | 温州科保塑料科技有限公司 | Hot-melt medical splint material and production process thereof |
| CN107661543A (en) * | 2017-11-14 | 2018-02-06 | 安徽斯麦特医学技术开发有限公司 | A kind of processing method of the polyurethane resin performed polymer of Medical macromolecular splint production |
| CN108084394A (en) * | 2017-12-25 | 2018-05-29 | 青岛科技大学 | A kind of shape memory hard polyurethane foam medical splint material and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181211 |
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