CN108970559A - A kind of production method of ultrasound-enhanced solid-liquid micro-reaction device - Google Patents
A kind of production method of ultrasound-enhanced solid-liquid micro-reaction device Download PDFInfo
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- CN108970559A CN108970559A CN201811083822.5A CN201811083822A CN108970559A CN 108970559 A CN108970559 A CN 108970559A CN 201811083822 A CN201811083822 A CN 201811083822A CN 108970559 A CN108970559 A CN 108970559A
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 100
- 239000007788 liquid Substances 0.000 title claims abstract description 33
- 238000002604 ultrasonography Methods 0.000 title claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 239000000758 substrate Substances 0.000 claims abstract description 56
- 238000004853 microextraction Methods 0.000 claims abstract description 27
- 230000007246 mechanism Effects 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims description 21
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 20
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 20
- 239000007787 solid Substances 0.000 claims description 11
- -1 polytetrafluoroethylene Polymers 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000010453 quartz Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 claims description 3
- 230000002572 peristaltic effect Effects 0.000 claims description 2
- XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical compound FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 11
- 238000002156 mixing Methods 0.000 description 11
- 239000012530 fluid Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000012546 transfer Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 238000001172 liquid--solid extraction Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000008676 import Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 230000005501 phase interface Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000002525 ultrasonication Methods 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
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- 238000012827 research and development Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0261—Solvent extraction of solids comprising vibrating mechanisms, e.g. mechanical, acoustical
- B01D11/0265—Applying ultrasound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00905—Separation
- B01J2219/00907—Separation using membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00925—Irradiation
- B01J2219/00932—Sonic or ultrasonic vibrations
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention provides a kind of production methods of ultrasound-enhanced solid-liquid micro-reaction device, described device includes reaction plate and super acoustic vibratory plate, the reaction plate is stacked gradually from top to bottom equipped with the first cover plate, first substrate, seperation film, second cover plate and the second substrate, gasket is equipped between first cover plate and the first substrate, the super acoustic vibratory plate is disc-shaped, it is characterized in that, first cover plate is equipped with round watch window, first substrate is equipped with round lower logical micro- extraction pond, second cover plate is equipped with circular hole, second substrate is equipped with round micro reaction pool, micro- extraction pond, circular hole is identical with the diameter of micro reaction pool, the center of circle is on same vertical line；The super acoustic vibratory plate is close to the second substrate lower surface and face the second substrate circle micro reaction pool, and further, the micro-reaction device is equipped with can be by the reaction substrate, the removable clamp mechanism of cover plate and gasket close fit.Described device integrated level is high, is miniaturized, is easy to operate, can be applied to the processing of micro test sample.
Description
Technical field
The present invention relates to a kind of reactors, relate more particularly to a kind of ultrasound-enhanced micro passage reaction, belong to experiment instrument
Device equipment technical field.
Technical background
Microreactor may replace the various functions and method in conventional chemical laboratory, because it has as a kind of new technology
Specific surface area is high, mass-and heat-transfer speed is fast, the mixing of reactant energy Quick uniform, integrated level is high, response parameter is easy to control, operation peace
Entirely, it is easy to amplify, the advantages that space occupied is small has increasingly caused increasingly since microreactor the 1990s comes out
The concern of more researchers.The micro-structure of microreactor has many advantages to increase biological or chemical repercussion study efficiency, reduces anti-
Answer object dosage with save the cost.The essence of phonochemistry technology is that ultrasonic wave propagates special " the cavitation effect of generation in liquid medium
Answer ", " cavitation effect " constantly generate countless internal pressures reach thousands of a atmospheric pressure micro- air pocket and constantly " explosion ", generate it is micro-
Strong impact wave in sight acts in sample matrices, so that extract is constantly separated in sample matrices, to realize
The purpose for accelerating chemical reaction, improving chemical yield.By microreactor in conjunction with ultrasonic technique, can mutually it display one's respective advantages,
Further strengthen reaction, shorten experimental period, improve reaction rate, reduces sample consumption.Currently, the research of microreactor takes
Greater advance was obtained, ultrasonic technique is applied to microreactor, Efficiency is remarkably improved, reduces research cost, significantly
Reduce reagent material loss, scientific value with higher and actual application prospect, but currently, the research and development of ultrasonic microreactor still
It so reports less.
CN103418321A discloses a kind of laminated type micro passage reaction that channel velocity is uniformly distributed.Including import cover board,
It is machined with micro channel array on first reaction plate, the second reaction plate and Outlet cover plate, the first reaction plate and the second reaction plate, alternately
It is stacked between import cover board and Outlet cover plate staggered relatively.Reacting fluid enters micro channel array by an inlet flow, from
Two outlet outflows, improve reacting fluid in the velocity flow profile uniformity of micro channel array, so as to effectively improve microchannel
The reaction efficiency of reactor.Meanwhile the flow dividing structure of import two outlets can be effectively reduced fluid and flow through microchannel plate
Answer the pressure loss of device.By the first reaction plate of multilayer and the second reaction board stacking, reaction scale can be expanded, improve reaction effect
Rate.Compared with the micro passage reaction of existing single inlet single-outlet, the reactor improves reaction uniformity, has reaction effect
The high feature low with fluid pressure loss of rate.
CN107051346A discloses a kind of micro passage reaction, and the reactor is by substrate, cover board, channel module, input
Pipe and efferent duct composition.The substrate of reactor is provided with input mixing chamber and output mixing chamber, input mixing chamber, output mixing chamber
It is connect respectively with channel module, input mixing chamber has input pipe connection, there is circular seal groove.Reactor cover board has input to mix
Room and output mixing chamber, input mixing chamber have input pipe connection, and output mixing chamber has efferent duct connection.Channel module is that upper end is opened
Mouthful reaction channel, have seal groove in channel module, there is the channel of texture structure in reaction channel.When channel module and substrate and
Cover board combined fastening under sealing element cooperation just forms micro passage reaction.It is described to can be used between two fluids mixing mass transfer biography
The micro passage reaction of thermal response, structure is simple, easy to operate, and management use cost is low, and hybrid reaction effect is good, can basis
Using suitable reaction channel is replaced, cleaning easy to disassemble is maintained.
CN104162395A discloses a kind of method for strengthening gas-liquid process in microreactor, and this method is in gas-liquid two-phase
Manifold is the super of application specific frequency in the gas-liquid microreactor of bubble flow, slug flow, bullet shape annular flow, stirring stream or annular flow
Sound regulates and controls gas phase transverse direction equivalent diameter and supersonic frequency in biphase gas and liquid flow, makes supersonic frequency and gas phase transverse direction equivalent diameter
Product reaches 1-40 mmkHz.This method causes disturbance and acoustic streaming using the cavitation of ultrasound and gas phase in a liquid, from
And strengthen gas-liquid mass transfer；The reunion in fluid between solid or dope or the adherency in microchannel wall surface can be destroyed simultaneously, from
And prevention and dredge blockage.Gas-liquid process intensification method of the invention is suitable for various gas liquid reactions, gas absorbs, gas separation
The fields such as purification.
CN103007859A discloses a kind of high-power ultrasonics microreactor.The ultrasonic wave microreactor will be big
Radiating surface is tubaeform sandwich transducer and microreactor are directly rigidly connected, it is made to resonate as a whole, entire ultrasound
Length of the wave microreactor on the direction perpendicular to previous irradiation face is just the half of ultrasonic wavelength.When entire ultrasonic wave is micro-
Reactor works in its resonant frequency, and microreactor is in Oscillation Amplitude maximum, makes to have in entire microreactor very strong
Ultrasonic energy.The ultrasound microreactor power is big, ultrasonic energy transmission efficiency is high, ultrasound-enhanced overlay area is big, can be effective
Strengthen the mixing of process fluid or mass transfer in microreactor, while also can solve the blockage problem of microreactor.
As described above, disclosing a variety of micro passage reactions in the prior art, these micro passage reactions are unique using it
Structure, have a variety of specific or general advantage, to have a good application prospect in multiple fields.But it is another
Aspect, although these advantages can be obtained, practical application request can bring challenges the prior art to microreactor.First,
Existing structure design is usually mixed solvent directly with sample, cannot achieve extraction isolation integral, and logical in micro- reaction
Setting, replacement, regeneration manufacture craft are cumbersome and complicated in road；Second, flowing is logical since the microchannel size in microreactor is small
It is often in laminar condition and surface tension effects is significant, keep the reinforcing of microchannel inner transmission matter relatively difficult, while being easy by impurity
Or process fluid blocking.Therefore, it is based on drawbacks described above, the dual excellent of microreactor and ultrasonic wave has been used in present invention collaboration
Gesture takes the double pool structures of micro- extraction pond, seperation film and micro reaction pool, applies ultrasound in microreactor, utilize ultrasound and liquid
The cavitation of phase makes solid-liquid phase interface high vibration and movement in microchannel, and causes disturbance and acoustic streaming in a liquid, from
And it can effectively strengthen solid-liquid mass transfer.Solid-liquid mass transfer effect is mainly controlled by sound intensity size, no matter in high flow rate or low flow velocity,
Very strong mass transfer effect can be reached.Meanwhile the vibration of microchannel wall surface and solid-liquid phase interface high vibration under ultrasonication
Caused disturbance can destroy the aggregation and solid in fluid between solid or dope or dope gluing in microchannel wall surface
It is attached, so as to prevent and dredge blockage.
Summary of the invention
For main problem existing for prior art, the main object of the present invention is: first is that integrated using super acoustic vibratory plate and micro- pond
One structure, provide a kind of integrated level it is high, it is compact-sized, be miniaturized, ultrasound-enhanced solid-liquid micro-reaction device easy to operate；
Second is that realizing the liquid-solid extraction of L grades of micro-examples of μ using micro- pool structure, solid-to-liquid ratio is reduced, reduces reagent consumption to reduce
Experimental cost；Third is that the double dominant of microreactor and ultrasound has been used in collaboration, takes and extract micro- pond, seperation film and react micro-
The double pool structures in pond solve classical microreactor and are used for the problems such as existing pressure difference greatly, is easily blocked, easily emulsified when liquid-solid extraction.
To achieve the above object, the technical solution adopted by the present invention is that: a kind of ultrasound-enhanced solid-liquid micro-reaction device, including
Reaction plate and super acoustic vibratory plate, the reaction plate are stacked gradually from top to bottom equipped with the first cover plate, the first substrate, seperation film, second
Cover plate and the second substrate are equipped with gasket between first cover plate and the first substrate, the super acoustic vibratory plate is disc-shaped, special
Sign is that the first cover plate is equipped with round watch window, and the first substrate is equipped with round lower logical micro- extraction pond, and the second cover plate is equipped with circle
Hole, the second substrate are equipped with round micro reaction pool, and micro- extraction pond, circular hole are identical with micro reaction pool diameter, and the center of circle is hung down same
On line；The super acoustic vibratory plate is close to the second substrate lower surface and face the second substrate circle micro reaction pool, further, described micro- anti-
Answering device to be equipped with can be by the reaction substrate, the removable clamp mechanism of cover plate and gasket close fit.
The reaction plate is equipped with micro- double pool structures for extracting pond and micro reaction pool, material choosing as a preferred technical solution,
From one kind of glass, quartz, polytetrafluoroethylene (PTFE).
First cover plate is equipped with round watch window as a preferred technical solution, described to observe extraction process
First patch material is polytetrafluoroethylene (PTFE), and the watch window material is glass.
First substrate is equipped with round lower logical micro- extraction pond as a preferred technical solution, and material is polytetrafluoroethyl-ne
Alkene, micro- extraction pond are mainly used for that solid-liquid micro-extraction occurs.
The seperation film is inclined tetrafluoroethene filter membrane as a preferred technical solution, is clipped in the first substrate with gasket seal
And second between cover plate, for placing solid sample.
Second cover plate is equipped with circular hole as a preferred technical solution, and material is polytetrafluoroethylene (PTFE), second cover plate
The feed liquor interface being connected at least provided with two with micro reaction pool and one go out liquid interface, the feed liquor interface and the micro wriggling of sample introduction
Pump connection, the liquid interface out can be connect with detection unit.
Second substrate is equipped with round micro reaction pool, micro- reaction of the micro reaction pool as a preferred technical solution,
Area's height is between 200-500 μm, and diameter is between 500-3000 μm.
As a preferred technical solution, between the super acoustic vibratory plate power 1-5W, equipped with external driver, when solvent stream
When crossing micro reaction pool, ultrasound shakes solvent upwards, and solvent carries out micro-extraction by seperation film and solid sample.
As a preferred technical solution, the clamp mechanism include be respectively arranged at it is upper above and below micro-reaction device
Intermediate plate and lower clamp plate, the upper clip and lower clamp plate are compressed by one group of fastening screw or disassembly, and material is flake aluminum.
Compared with prior art, the beneficial effect that the present invention obtains is:
(1) for the present invention using super acoustic vibratory plate and the integrated structure of micro reaction pool, over all Integration degree is high, compact-sized, miniature
Change, is easy to operate；
(2) present invention uses micro- pool structure, realizes the liquid-solid extraction of L grades of micro-examples of μ, can reduce solid-to-liquid ratio, reduces reagent
Consumption is to reduce experimental cost；
(3) double dominant of microreactor and ultrasonic wave has been used in present invention collaboration, use micro- extractions pond, seperation film and it is micro- instead
Double pool structures of Ying Chi, ultrasonication make solvent enter micro- extraction pond from micro reaction pool, sufficiently and solid sample by seperation film
Contact, while guaranteeing extraction efficiency, avoidable solid sample enters micro reaction pool, realizes extraction separation one, simultaneously
It solves classical microreactor and is used for the problems such as existing pressure difference greatly, is easily blocked, easily emulsified when liquid-solid extraction.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing does simple introduction.
A kind of ultrasound-enhanced solid-liquid micro-reaction device, including reaction plate and super acoustic vibratory plate, the reaction plate from top to bottom according to
Secondary stacking is equipped with the first cover plate, the first substrate, seperation film, the second cover plate and the second substrate, first cover plate and the first substrate
Between be equipped with gasket, the super acoustic vibratory plate is disc-shaped, which is characterized in that the first cover plate is equipped with round watch window, first
Substrate is equipped with round lower logical micro- extraction pond, and the second cover plate is equipped with circular hole, and the second substrate is equipped with round micro reaction pool, described micro- to mention
Take pond, circular hole identical with micro reaction pool diameter, the center of circle is on same vertical line；The super acoustic vibratory plate is close to the second substrate lower surface simultaneously
Face the second substrate circle micro reaction pool, further, the micro-reaction device is equipped with can be by the reaction substrate, cover plate and sealing
Pad the removable clamp mechanism of close fit.
Fig. 1 is schematic structural view of the invention；Fig. 2 is the face schematic structural view of the invention A-A cross-sectional view, and Fig. 3 is present invention top
View；Fig. 4 is reaction substrate cover plate floor map, wherein in Fig. 1 to Fig. 4, it is following that each number designation respectively refers to generation
Concrete meaning, element and/or component.
In figure: 1- reaction plate, the first cover plate of 11-, the first substrate of 12-, 13- seperation film, the second cover plate of 14-, the second base of 15-
Piece, 16- watch window, the micro- extraction pond 17-, 18- circular hole, 19- micro reaction pool, 120- feed liquor interface, 121- go out liquid interface, and 2- is super
Acoustic vibratory plate, 3- hold-down mechanism, 31- upper clip, 32- lower clamp plate, 33- fastening screw.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
As Fig. 1,2 and 3 it is common shown in, the use of the new type discloses a kind of ultrasound-enhanced solid-liquid micro-reaction device, including anti-
Plate 1 and super acoustic vibratory plate 2 are answered, the reaction plate is stacked gradually from top to bottom equipped with the first cover plate 11, the first substrate 12, seperation film
13, the second cover plate 14 and the second substrate 15 are equipped with gasket, the ultrasound vibration between first cover plate 11 and the first substrate 12
Piece 2 is disc-shaped, which is characterized in that the first cover plate 11 is equipped with round watch window 16, and the first substrate 12 is equipped with round lower logical
Micro- extraction pond 17, the second cover plate are equipped with circular hole 18, and the second substrate is equipped with round micro reaction pool 19, micro- extraction pond 17, circular hole
18 is identical with 19 diameter of micro reaction pool, and the center of circle is on same vertical line；The super acoustic vibratory plate 2 is close to 15 lower surface of the second substrate and just
To the second substrate circle micro reaction pool 19, further, the micro-reaction device is equipped with can be by the reaction substrate, cover plate and sealing
Pad the removable clamp mechanism 3 of close fit.
As shown in Figure 1, Figure 2, Fig. 3 and Fig. 4 is jointly shown, and the reaction plate 1 is equipped with pair of micro- extraction pond 17 and micro reaction pool 19
Pool structure, material are selected from one kind of glass, quartz, polytetrafluoroethylene (PTFE).
As shown in Figure 1, Figure 2, Fig. 3 and Fig. 4 is jointly shown, and first cover plate 11 is equipped with round watch window 16, to observe
Extraction process, first patch material are polytetrafluoroethylene (PTFE), and the watch window material is glass.
As shown in Figure 1, Figure 2, Fig. 3 and Fig. 4 is jointly shown, and first substrate 12 is equipped with round lower logical micro- extraction pond 17, material
Material is polytetrafluoroethylene (PTFE), and micro- extraction pond is mainly used for that solid-liquid micro-extraction occurs.
As Fig. 1 and Fig. 2 jointly shown in, 13 material of seperation film is inclined tetrafluoroethene filter membrane, is clipped in the with gasket seal
Between one substrate 11 and the second cover plate 14, for placing solid sample.
As Fig. 2 and Fig. 3 jointly shown in, second cover plate 14 be equipped with circular hole 18, material is polytetrafluoroethylene (PTFE), described second
Feed liquor interface 120 that cover plate 14 is connected at least provided with two with reaction tank and one go out liquid interface 121, the feed liquor interface 120
It is connect with the micro peristaltic pump of sample introduction, the liquid interface 121 out can be connect with detection unit.
As Fig. 2 and Fig. 3 jointly shown in, second substrate 15 is equipped with round micro reaction pool 19, and the micro reaction pool is micro- anti-
Answer area's height between 200-500 μm, diameter is between 500-3000 μm.
As Fig. 1 and Fig. 2 jointly shown in, between the super 2 power 1-5W of acoustic vibratory plate, equipped with external driver, work as solvent
When flowing through micro reaction pool, ultrasound shakes solvent upwards, and solvent carries out micro-extraction by seperation film and solid sample.
As shown in Figure 1, the clamp mechanism 3 includes 31 He of upper clip being respectively arranged above and below micro-reaction device
Lower clamp plate 32, the upper clip 31 and lower clamp plate 32 are compressed by one group of fastening screw 33 or disassembly, and material is flake aluminum.
Claims (9)
1. the present invention provides a kind of production method of ultrasound-enhanced solid-liquid micro-reaction device, including reaction plate and super acoustic vibratory plate,
The reaction plate is stacked gradually from top to bottom equipped with the first cover plate, the first substrate, seperation film, the second cover plate and the second substrate, institute
It states and is equipped with gasket between the first cover plate and the first substrate, the super acoustic vibratory plate is disc-shaped, which is characterized in that the first cover plate is set
There is round watch window, the first substrate is equipped with round lower logical micro- extraction pond, and the second cover plate is equipped with circular hole, and the second substrate is equipped with circle
Shape micro reaction pool, micro- extraction pond, micro reaction pool are identical with Circularhole diameter, and the center of circle is on same vertical line；The super acoustic vibratory plate
It is close to the second substrate lower surface and face the second substrate circle micro reaction pool, further, the micro-reaction device is equipped with can be by institute
State the removable clamp mechanism of reaction substrate, cover plate and gasket close fit.
2. reaction plate according to claim 1, which is characterized in that the reaction plate is equipped with micro- extraction pond and micro reaction pool
Double pool structures, material are selected from one kind of glass, quartz, polytetrafluoroethylene (PTFE).
3. the first cover plate according to claim 1, which is characterized in that first cover plate is equipped with round watch window, with
Just extraction process is observed, first patch material is polytetrafluoroethylene (PTFE), and the watch window material is glass.
4. the first substrate according to claim 1, which is characterized in that first substrate is equipped with round lower logical micro- extraction
Pond, material are polytetrafluoroethylene (PTFE), and micro- extraction pond is mainly used for that solid-liquid micro-extraction occurs.
5. seperation film according to claim 1, which is characterized in that the seperation film is inclined tetrafluoroethene filter membrane, with sealing
Shim clip is between the first substrate and the second cover plate, for placing solid sample.
6. the second cover plate according to claim 1, which is characterized in that second cover plate is equipped with circular hole, and material is poly- four
Vinyl fluoride, feed liquor interface that second cover plate is connected at least provided with two with reaction tank and one go out liquid interface, the feed liquor
Interface is connect with the micro peristaltic pump of sample introduction, and the liquid interface out can be connect with detection unit.
7. the second substrate according to claim 1, which is characterized in that second substrate is equipped with round micro reaction pool, institute
Micro- reaction zone height of micro reaction pool is stated between 200-500 μm, diameter is between 500-3000 μm.
8. super acoustic vibratory plate according to claim 1, which is characterized in that between the super acoustic vibratory plate power 1-5W, be equipped with outer
The driver set, when solvent flows through micro reaction pool, ultrasound shakes solvent upwards, solvent by seperation film and solid sample into
Row micro-extraction.
9. clamp mechanism according to claim 1, which is characterized in that the clamp mechanism includes being respectively arranged at micro- reaction
Upper clip and lower clamp plate above and below device, the upper clip and lower clamp plate are compressed by one group of fastening screw or disassembly,
Material is flake aluminum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811083822.5A CN108970559B (en) | 2018-09-18 | 2018-09-18 | Manufacturing method of ultrasonic reinforced solid-liquid micro-reaction device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811083822.5A CN108970559B (en) | 2018-09-18 | 2018-09-18 | Manufacturing method of ultrasonic reinforced solid-liquid micro-reaction device |
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| CN108970559B CN108970559B (en) | 2023-10-27 |
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| CN101169403A (en) * | 2006-10-25 | 2008-04-30 | 中国科学院大连化学物理研究所 | Micro-fluidic chip and its preparation and uses |
| CN202512094U (en) * | 2011-12-05 | 2012-10-31 | 中国科学院大连化学物理研究所 | Separating device of volatile organisms in water based on composite membrane |
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