CN108938879A - A kind of set a broken bone blood-activating and pain-stopping capsules and its preparation process - Google Patents

A kind of set a broken bone blood-activating and pain-stopping capsules and its preparation process Download PDF

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CN108938879A
CN108938879A CN201811004152.3A CN201811004152A CN108938879A CN 108938879 A CN108938879 A CN 108938879A CN 201811004152 A CN201811004152 A CN 201811004152A CN 108938879 A CN108938879 A CN 108938879A
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parts
blood
pain
activating
broken bone
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郭耀军
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention discloses a kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, the content includes following raw material: donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, peppermint, grape seed extract, sea-buckthorn, lettuce, the root of Dahurain angelica, Radix Glycyrrhizae.The invention also discloses the preparation processes of the set a broken bone blood-activating and pain-stopping capsules.Set a broken bone blood-activating and pain-stopping capsules prepared by the present invention have good promoting blood circulation and stopping pain effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduce the healing time of fracture site；The present invention passes through the mutual cooperation of peppermint, grape seed extract, sea-buckthorn and lettuce, effectively increase the mutual synergy of traditional Chinese medicinal components, it is low in cost simultaneously, it has no toxic side effect, it is prepared into convenient to take after capsule, it is significant to the fracture at the four limbs position growth result that heals rapidly, it has a vast market foreground.

Description

A kind of set a broken bone blood-activating and pain-stopping capsules and its preparation process
Technical field
The present invention relates to field of medicaments, specifically a kind of set a broken bone blood-activating and pain-stopping capsules and its preparation process.
Background technique
Fracture is that the continuity of bone structure is broken completely or partially.Generation fracture is mostly due to violence and directly acts on The a certain position of bone and cause the portion fracture, so that injury is fractured, often with different degrees of soft tissue injury.Due to leading to after wound It often will appear the symptoms such as wound severe pain, local swelling, extravasated blood, not only bad for the recovery at injury, also seriously affect people Daily life, in order to improve the recovery effects of bone fracture, need using dedicated set a broken bone drug carry out promoting blood circulation and stopping pain Treatment.
But be mostly currently on the market outer clothes for the blood-activating analgesic of set a broken bone, often effect is general, only to swollen Pain surface portion carries out relieving pain and activating blood circulation, can not go deep into the formation that bone fracture inner portion is invigorated blood circulation and promotes poroma, lead to bone The healing time of folding part position is too long, is unfavorable for the rehabilitation of patient.Therefore, it is necessary to design, one kind is efficient, type set a broken bone for oral administration is living Blood and relieving pain capsule.
Summary of the invention
It is living the object of the invention is to provide a kind of set a broken bone in order to solve above-mentioned problems of the prior art Blood and relieving pain capsule and its preparation process.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 10-25 parts of donkey-hide gelatin, 16-26 parts of Radix Notoginseng, 4-8 parts of safflower, 6-16 parts of dragon's blood, 1-5 parts of peppermint, 1-5 parts of grape seed extract, 4-10 parts of sea-buckthorn, 5-20 parts of lettuce, 4-10 parts of the root of Dahurain angelica, 6-14 parts of Radix Glycyrrhizae.
Further, the content includes the following raw material according to parts by weight: 12-20 parts of donkey-hide gelatin, 20-24 parts of Radix Notoginseng, 5-7 parts of safflower, 8-12 parts of dragon's blood, 2-4 parts of peppermint, 2-4 parts of grape seed extract, 6-8 parts of sea-buckthorn, 8-12 parts of lettuce, root of Dahurain angelica 6-8 Part, 8-12 parts of Radix Glycyrrhizae.
Further, the content includes the following raw material according to parts by weight: 18 parts of donkey-hide gelatin, 22 parts of Radix Notoginseng, safflower 6 Part, 11 parts of dragon's blood, 3 parts of peppermint, 3 parts of grape seed extract, 7 parts of sea-buckthorn, 11 parts of lettuce, 7 parts of the root of Dahurain angelica, 11 parts of Radix Glycyrrhizae.
Further, the capsule shells are one in No. 0 capsule shells, No. 1 capsule shells, No. 2 capsule shells or No. 3 capsule shells Kind；The preparation method of the grape seed extract is to weigh suitable grape pip to be cleaned up with deionized water, and 20 times of bodies are added The ethanol solution that long-pending mass concentration is 70% extracts 120min at 35 DEG C, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, Freeze-drying 18h is carried out at -20 DEG C, then is crushed to 200 mesh to get the grape seed extract.
A kind of preparation process of set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；By being handled in the electric field, the mixed effect of raw material is effectively increased, and then be conducive to Improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；It is logical It crosses and is extracted using supercritical carbon dioxide extraction method, effectively increase the purity of drug, and then be conducive to improve to invigorate blood circulation and stop Pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get.
Further, in step 2), the solid-liquid ratio of the refluxing extraction is 1:7.
Further, in step 3), the current density of the forward current and reverse current is 70A/m2。
Further, in step 4), the pressure of the extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h.
The set a broken bone blood-activating and pain-stopping capsules are preparing the purposes in bone healing drug.
Sea-buckthorn is the dry mature fruit of Elaeangnaceae plant sea-buckthorn, sour, puckery, warm-natured, returns spleen, stomach, lung, the heart channel of Hang-Shaoyin, tool There is the effect of reinforcing spleen to promote digestion, cough-relieving apophlegmatic, promoting blood circulation to remove blood stasis, can be used for spleen eating less, dyspeptic abdominalgia, coughing with a lot of sputum, chest impediment and cardialgia, Blood stasis closed, falls that flutter the stasis of blood swollen.
Lettuce, Chinese medicine name is the stem and leaf of composite family lettuce platymiscium lettuce, sweet in flavor, cool in nature, enters intestines, stomach meridian, can removing the heart-fire, It reduces phlegm and internal heat, solution burns toast fire toxin, and diuresis helps digestion, and sobers up, and mends muscles and bones, opens diaphragm heat, qualcomm meridian, removing foul breath, white teeth, bright eyes can Hot urination is controlled, is short of, hematuria etc., while the iron ion in lettuce is easy to be absorbed by the body, often feeding can be prevented and treated with fresh lettuce Hypoferric anemia.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
1) set a broken bone blood-activating and pain-stopping capsules prepared by the present invention have good promoting blood circulation and stopping pain effect, by being with donkey-hide gelatin Monarch drug in a prescription plays kidney tonifying and enriching blood, mitigates bone pain, and the effect for accelerating the silly growth of bone plays promoting blood circulation using Radix Notoginseng, safflower, dragon's blood as ministerial drug It dispels addiction, Dingchuan is moisturized, and enters Liver Channel and broken addiction blood, and dissipating bind gas leads to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, rises To all medicines of synergism, sensible, coordination between ascending and descending in table, myogenic pain relieving effect can be goed deep into bone fracture inner portion and lived by for oral administration Blood and the formation for promoting poroma, reduce the healing time of fracture site；
2) present invention passes through the mutual cooperation of peppermint, grape seed extract, sea-buckthorn and lettuce, effectively increases traditional Chinese medicinal components Mutual synergy, while it is low in cost, have no toxic side effect, be prepared into it is convenient to take after capsule, to the fracture at four limbs position Healing growth result is significant rapidly；
3) present invention is by carrying out refluxing extraction, current processing to raw material substep, and cooperates with supercritical carbon dioxide extracting Method is extracted, and the extraction effect of drug is effectively increased, and then effectively increases promoting blood circulation and stopping pain effect, is conducive to connect at bone fracture Bone continues muscle, and swelling and pain relieving effect is played while nourishing qi and blood, is had a vast market foreground.
Specific embodiment
The present invention is described in detail combined with specific embodiments below.The present embodiment is based on the technical solution of the present invention Implemented, the detailed implementation method and specific operation process are given, but protection scope of the present invention be not limited to it is following Embodiment.
Embodiment 1
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 10 parts of donkey-hide gelatin, 16 parts of Radix Notoginseng, 4 parts of safflower, 6 parts of dragon's blood, 1 part of peppermint, grape seed extract 1 Part, 4 parts of sea-buckthorn, 5 parts of lettuce, 4 parts of the root of Dahurain angelica, 6 parts of Radix Glycyrrhizae；By using donkey-hide gelatin as monarch drug in a prescription, playing kidney tonifying and enriching blood, mitigates bone pain, add The effect of the silly growth of fast bone plays promoting blood circulation and dispels addiction using Radix Notoginseng, safflower, dragon's blood as ministerial drug, and Dingchuan is moisturized, and enters Liver Channel and broken addiction blood, Dissipating bind gas, leads to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, plays all medicines of synergism, sensible, coordination between ascending and descending in table, Myogenic pain relieving effect reduces fractures by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma The healing time of position；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
Embodiment 2
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 25 parts of donkey-hide gelatin, 26 parts of Radix Notoginseng, 8 parts of safflower, 16 parts of dragon's blood, 5 parts of peppermint, grape seed extract 5 Part, 10 parts of sea-buckthorn, 20 parts of lettuce, 10 parts of the root of Dahurain angelica, 14 parts of Radix Glycyrrhizae；By using donkey-hide gelatin as monarch drug in a prescription, playing kidney tonifying and enriching blood, mitigate bone Pain accelerates the effect of the silly growth of bone, using Radix Notoginseng, safflower, dragon's blood as ministerial drug, plays promoting blood circulation and dispels addiction, Dingchuan moisturizes, enters Liver Channel and break Addiction blood, dissipating bind gas lead to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, play all medicines of synergism, sensible, lifting in table Coordinate, myogenic pain relieving effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduces bone The healing time of folding part position；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
Embodiment 3
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 17.5 parts of donkey-hide gelatin, 21 parts of Radix Notoginseng, 6 parts of safflower, 11 parts of dragon's blood, 3 parts of peppermint, grape pip extract 3 parts of object, 7 parts of sea-buckthorn, 12.5 parts of lettuce, 7 parts of the root of Dahurain angelica, 10 parts of Radix Glycyrrhizae；By playing kidney tonifying and enriching blood using donkey-hide gelatin as monarch drug in a prescription, mitigate Bone pain accelerates the effect of the silly growth of bone, using Radix Notoginseng, safflower, dragon's blood as ministerial drug, plays promoting blood circulation and dispels addiction, and Dingchuan is moisturized, enter Liver Channel and Broken addiction blood, dissipating bind gas lead to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, play all medicines of synergism, sensible, liter in table Drop is coordinated, myogenic pain relieving effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduces The healing time of fracture site；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
Embodiment 4
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 12 parts of donkey-hide gelatin, 20 parts of Radix Notoginseng, 5 parts of safflower, 8 parts of dragon's blood, 2 parts of peppermint, grape seed extract 2 Part, 6 parts of sea-buckthorn, 8 parts of lettuce, 6 parts of the root of Dahurain angelica, 8 parts of Radix Glycyrrhizae；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
In the present embodiment, the set a broken bone blood-activating and pain-stopping capsules are mitigated by playing kidney tonifying and enriching blood using donkey-hide gelatin as monarch drug in a prescription Bone pain accelerates the effect of the silly growth of bone, using Radix Notoginseng, safflower, dragon's blood as ministerial drug, plays promoting blood circulation and dispels addiction, and Dingchuan is moisturized, enter Liver Channel and Broken addiction blood, dissipating bind gas lead to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, play all medicines of synergism, sensible, liter in table Drop is coordinated, myogenic pain relieving effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduces The healing time of fracture site.
Embodiment 5
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 20 parts of donkey-hide gelatin, 24 parts of Radix Notoginseng, 7 parts of safflower, 12 parts of dragon's blood, 4 parts of peppermint, grape seed extract 4 Part, 8 parts of sea-buckthorn, 12 parts of lettuce, 8 parts of the root of Dahurain angelica, 12 parts of Radix Glycyrrhizae；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
In the present embodiment, the set a broken bone blood-activating and pain-stopping capsules are mitigated by playing kidney tonifying and enriching blood using donkey-hide gelatin as monarch drug in a prescription Bone pain accelerates the effect of the silly growth of bone, using Radix Notoginseng, safflower, dragon's blood as ministerial drug, plays promoting blood circulation and dispels addiction, and Dingchuan is moisturized, enter Liver Channel and Broken addiction blood, dissipating bind gas lead to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, play all medicines of synergism, sensible, liter in table Drop is coordinated, myogenic pain relieving effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduces The healing time of fracture site.
Embodiment 6
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 16 parts of donkey-hide gelatin, 22 parts of Radix Notoginseng, 6 parts of safflower, 10 parts of dragon's blood, 3 parts of peppermint, grape seed extract 3 Part, 7 parts of sea-buckthorn, 10 parts of lettuce, 7 parts of the root of Dahurain angelica, 10 parts of Radix Glycyrrhizae；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
In the present embodiment, the set a broken bone blood-activating and pain-stopping capsules are mitigated by playing kidney tonifying and enriching blood using donkey-hide gelatin as monarch drug in a prescription Bone pain accelerates the effect of the silly growth of bone, using Radix Notoginseng, safflower, dragon's blood as ministerial drug, plays promoting blood circulation and dispels addiction, and Dingchuan is moisturized, enter Liver Channel and Broken addiction blood, dissipating bind gas lead to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, play all medicines of synergism, sensible, liter in table Drop is coordinated, myogenic pain relieving effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduces The healing time of fracture site.
Embodiment 7
A kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content includes Below according to the raw material of parts by weight: 18 parts of donkey-hide gelatin, 22 parts of Radix Notoginseng, 6 parts of safflower, 11 parts of dragon's blood, 3 parts of peppermint, grape seed extract 3 Part, 7 parts of sea-buckthorn, 11 parts of lettuce, the root of Dahurain angelica 7,11 parts of Radix Glycyrrhizae；
Wherein, the capsule shells are No. 0 capsule shells；The preparation method of the grape seed extract is to weigh suitable grape Seed is cleaned up with deionized water, and the ethanol solution that the mass concentration that 20 times of volumes are added is 70% is extracted at 35 DEG C 120min, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, freeze-drying 18h is carried out at -20 DEG C, then be crushed to 200 mesh to get institute State grape seed extract.
In the present embodiment, the preparation process of the set a broken bone blood-activating and pain-stopping capsules, specifically includes the following steps:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to respectively after being cleaned up and dried with deionized water It 140 μm, is then uniformly mixed, obtains mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), often Secondary 140min, filtering merge extracting solution three times and be concentrated under reduced pressure into the medicinal extract that relative density is 1.24 at 30 DEG C, and vacuum is dry Dry to get dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；The solid-liquid ratio of the refluxing extraction is 1:7；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, is cleaned up and is dried with deionized water It is uniformly mixed after dry, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Middle processing 14 seconds, obtains mixture C；The current density of the forward current and reverse current is 70A/m2；By in the electric field It is handled, effectively increases the mixed effect of raw material, and then be conducive to improve promoting blood circulation and stopping pain effect；
4) grape seed extract is weighed according to parts by weight, sequentially added in mixture B and step 3) obtained in step 2) Obtained mixture C carries out extraction 2 hours using supercritical carbon dioxide extraction method after mixing, obtains extract D；Institute The pressure for stating extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h；By using supercritical carbon dioxide extraction method It is extracted, effectively increases the purity of drug, and then be conducive to improve promoting blood circulation and stopping pain effect；
5) extract D obtained in step 4) is crossed into 200 meshes, being then charged into capsule shells and weight is made is 0.3 gram/ Capsule to get；By carrying out refluxing extraction, current processing to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to carry out Extraction, effectively increases the extraction effect of drug, and then effectively increase promoting blood circulation and stopping pain effect, and it is continuous to be conducive to synthetism at bone fracture Muscle plays swelling and pain relieving effect while nourishing qi and blood.
In the present embodiment, the set a broken bone blood-activating and pain-stopping capsules are mitigated by playing kidney tonifying and enriching blood using donkey-hide gelatin as monarch drug in a prescription Bone pain accelerates the effect of the silly growth of bone, using Radix Notoginseng, safflower, dragon's blood as ministerial drug, plays promoting blood circulation and dispels addiction, and Dingchuan is moisturized, enter Liver Channel and Broken addiction blood, dissipating bind gas lead to stagnant blood, and detumescence ding-tong effect is to make medicine with the root of Dahurain angelica, Radix Glycyrrhizae, play all medicines of synergism, sensible, liter in table Drop is coordinated, myogenic pain relieving effect, by the formation for oral administration that can go deep into bone fracture inner portion and be invigorated blood circulation and promote poroma, reduces The healing time of fracture site.
Sea-buckthorn is the dry mature fruit of Elaeangnaceae plant sea-buckthorn, sour, puckery, warm-natured, returns spleen, stomach, lung, the heart channel of Hang-Shaoyin, tool There is the effect of reinforcing spleen to promote digestion, cough-relieving apophlegmatic, promoting blood circulation to remove blood stasis, can be used for spleen eating less, dyspeptic abdominalgia, coughing with a lot of sputum, chest impediment and cardialgia, Blood stasis closed, falls that flutter the stasis of blood swollen.
Lettuce, Chinese medicine name is the stem and leaf of composite family lettuce platymiscium lettuce, sweet in flavor, cool in nature, enters intestines, stomach meridian, can removing the heart-fire, It reduces phlegm and internal heat, solution burns toast fire toxin, and diuresis helps digestion, and sobers up, and mends muscles and bones, opens diaphragm heat, qualcomm meridian, removing foul breath, white teeth, bright eyes can Hot urination is controlled, is short of, hematuria etc., while the iron ion in lettuce is easy to be absorbed by the body, often feeding can be prevented and treated with fresh lettuce Hypoferric anemia.
Present invention has the advantages that set a broken bone blood-activating and pain-stopping capsules prepared by the present invention are imitated with good promoting blood circulation and stopping pain Fruit mitigates bone pain, accelerates the effect of the silly growth of bone, with Radix Notoginseng, safflower, dragon's blood by using donkey-hide gelatin as monarch drug in a prescription, playing kidney tonifying and enriching blood It for ministerial drug, plays promoting blood circulation and dispels addiction, Dingchuan is moisturized, and enters Liver Channel and broken addiction blood, dissipating bind gas leads to stagnant blood, detumescence ding-tong effect, with white The root of Dahurian angelica, Radix Glycyrrhizae are to make medicine, play all medicines of synergism, sensible, coordination between ascending and descending in table, and myogenic pain relieving effect can go deep into bone by for oral administration Hurt the formation that inner portion is invigorated blood circulation and promotes poroma, reduces the healing time of fracture site；The present invention passes through peppermint, grape Seed extract, sea-buckthorn and the mutual cooperation of lettuce effectively increase the mutual synergy of traditional Chinese medicinal components, while low in cost, Have no toxic side effect, be prepared into it is convenient to take after capsule, it is significant to the fracture at the four limbs position growth result that heals rapidly；The present invention is logical It crosses and refluxing extraction, current processing is carried out to raw material substep, and supercritical carbon dioxide extraction method is cooperateed with to be extracted, effectively improve The extraction effect of drug, and then promoting blood circulation and stopping pain effect is effectively increased, be conducive to reunion of bone at bone fracture, in nourishing qi and blood Swelling and pain relieving effect is played simultaneously, is had a vast market foreground.
The above description of the embodiments is intended to facilitate ordinary skill in the art to understand and use the invention. Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein general Principle is applied in other embodiments without having to go through creative labor.There is no need and unable to give all embodiments With exhaustion.Therefore, the present invention is not limited to the above embodiments, and those skilled in the art's announcement according to the present invention does not depart from this hair The improvement and modification that bright scope is made all should be within protection scope of the present invention.

Claims (10)

1. a kind of set a broken bone blood-activating and pain-stopping capsules, including capsule shells and content, which is characterized in that the content include with Under according to parts by weight raw material: 10-25 parts of donkey-hide gelatin, 16-26 parts of Radix Notoginseng, 4-8 parts of safflower, 6-16 parts of dragon's blood, 1-5 parts of peppermint, Portugal 1-5 parts of grape seed extract, 4-10 parts of sea-buckthorn, 5-20 parts of lettuce, 4-10 parts of the root of Dahurain angelica, 6-14 parts of Radix Glycyrrhizae.
2. set a broken bone blood-activating and pain-stopping capsules according to claim 1, which is characterized in that the content includes pressing below According to the raw material of parts by weight: 12-20 parts of donkey-hide gelatin, 20-24 parts of Radix Notoginseng, 5-7 parts of safflower, 8-12 parts of dragon's blood, 2-4 parts of peppermint, grape pip 2-4 parts of extract, 6-8 parts of sea-buckthorn, 8-12 parts of lettuce, 6-8 parts of the root of Dahurain angelica, 8-12 parts of Radix Glycyrrhizae.
3. set a broken bone blood-activating and pain-stopping capsules according to claim 2, which is characterized in that the content includes pressing below According to the raw material of parts by weight: 18 parts of donkey-hide gelatin, 22 parts of Radix Notoginseng, 6 parts of safflower, 11 parts of dragon's blood, 3 parts of peppermint, 3 parts of grape seed extract, sand 7 parts of spine, 11 parts of lettuce, 7 parts of the root of Dahurain angelica, 11 parts of Radix Glycyrrhizae.
4. set a broken bone blood-activating and pain-stopping capsules according to claim 3, which is characterized in that the capsule shells are No. 0 capsule One of shell, No. 1 capsule shells, No. 2 capsule shells or No. 3 capsule shells.
5. set a broken bone blood-activating and pain-stopping capsules according to claim 1, which is characterized in that the system of the grape seed extract Preparation Method is to weigh suitable grape pip to be cleaned up with deionized water, and the ethyl alcohol that the mass concentration of 20 times of volumes is 70% is added Solution extracts 120min at 35 DEG C, then extracting solution is carried out ethyl alcohol is recovered under reduced pressure, and freeze-drying 18h is carried out at -20 DEG C, then 200 mesh are crushed to get the grape seed extract.
6. a kind of preparation process of set a broken bone blood-activating and pain-stopping capsules a method as claimed in any one of claims 1 to 5, which is characterized in that tool Body the following steps are included:
1) peppermint, sea-buckthorn and lettuce are weighed according to parts by weight, is crushed to 140 μ after being cleaned up and dried with deionized water respectively Then m is uniformly mixed, obtain mixture A；
2) ethyl alcohol refluxing extraction 3 times at 65 DEG C that concentration is 50% will be added in mixture A obtained in step 1), every time 140min, filtering merges extracting solution three times and be concentrated under reduced pressure into relative density at 30 DEG C and is 1.24 medicinal extract, and is dried in vacuo It gets dry extract, it is 200 targeted fine powders that dry cream, which is ground into partial size, obtains mixture B；
3) donkey-hide gelatin, Radix Notoginseng, safflower, dragon's blood, the root of Dahurain angelica and Radix Glycyrrhizae are weighed according to parts by weight, after being cleaned up and dried with deionized water It is uniformly mixed, is then crushed to 40 mesh, then be placed in forward dc electric field and handle 24 seconds, is subsequently placed in reversed DC electric field Reason 14 seconds, obtains mixture C；
4) grape seed extract is weighed according to parts by weight, sequentially adds and is obtained in mixture B and step 3) obtained in step 2) Mixture C, after mixing using supercritical carbon dioxide extraction method carry out extraction 2 hours, obtain extract D；
5) extract D obtained in step 4) is crossed into 200 meshes, is then charged into capsule shells and the glue that weight is 0.3 gram/is made Capsule to get.
7. the preparation process of set a broken bone blood-activating and pain-stopping capsules according to claim 6, which is characterized in that in step 2), The solid-liquid ratio of the refluxing extraction is 1:7.
8. the preparation process of set a broken bone blood-activating and pain-stopping capsules according to claim 7, which is characterized in that in step 3), The current density of the forward current and reverse current is 70A/m2。
9. the preparation process of set a broken bone blood-activating and pain-stopping capsules according to claim 8, which is characterized in that in step 4), The pressure of the extraction is 25 megapascal, and temperature is 28 DEG C, and flow velocity is 20 ls/h.
10. a kind of set a broken bone blood-activating and pain-stopping capsules a method as claimed in any one of claims 1 to 5 are in preparing bone healing drug Purposes.
CN201811004152.3A 2018-08-30 2018-08-30 A kind of set a broken bone blood-activating and pain-stopping capsules and its preparation process Pending CN108938879A (en)

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