CN108938673A - A kind of drug and preparation method thereof for treating otitis media suppurative - Google Patents
A kind of drug and preparation method thereof for treating otitis media suppurative Download PDFInfo
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating otitis media suppurative；It is related to medical manufacture technology field；Raw material including following parts by weight: 1-5 parts of honeycomb, 3-8 parts of borneol, 3-8 parts of alum；Preparation method is added after water after being sufficiently mixed and is ultrasonically treated, borneol and alum is added, ultrasonic treatment obtains mixture again the following steps are included: be ground into powdery after honeycomb is freezed；Mixture is placed under natural light after standing concentration after sealing standing again and obtains the drug；The present invention is acted on by the way that honeycomb to be crushed to simultaneously low temperature ultrasonic under freezing conditions, do not destroy effective component in honeycomb it is active under the premise of discharge completely, in conjunction with the synergic remove of borneol and alum, hence it is evident that improve drug in the therapeutic effect for the treatment of otitis media suppurative；Can 98% or more killing suppurative bacterium, significant effect be higher than natural honeycomb sterilizing rate.
Description
Technical field
The present invention relates to medical manufacture technology fields, and in particular to a kind of drug for treating otitis media suppurative and its preparation
Method.
Background technique
Tympanitis is to involve the inflammatory of all or part of structure of middle ear (including Eustachian tube, tympanum, tympanic antrum and mastoid air cell)
Lesion is apt to occur in children.Apyetous and suppurative two major classes can be divided into.Suppurative person be divided into it is acute and chronic, it is acute
Purulent otitis media: otitis media caused by being infected by suppurative bacterium, symptom are mainly otalgia, suppurate.It may in tympanum
There are a large amount of festers, will appear the tympanic membrane perforation when pressure is big, suppurates in external auditory canal；Chronic secretory otitis media: often because of acute stage
Delay is not cured, can also be oppressed because of Eustachian tube dysfunction, pharynx nasalis occupy-place (such as adenoids, nasopharyngeal carcinoma),
Radiotherapy etc. causes；Refer to middle-ear mucosa, periosteum or the chronic suppurative inflammation as deep as sclerotin.This disease is clinically more normal
See, in Chang Yier intermittently or continually property suppurate, the tympanic membrane perforation, Hearing be main clinical manifestation, can cause when serious encephalic,
Complication outside cranium.
Containing a large amount of bee clothing (such as placenta of people) in honeycomb, honeybee one produces the bee pupa of ten five to ten eight batches per year, that
Just there are ten five to ten eight bee placentas in one slight nest, be also exactly that honeybee acquisition pollen is stored among honeycomb,
The effect of essence of pollen is also left in nest wax after dissolution, pollen and effect, pollen effect is extensive, academician of the Chinese Academy of Sciences,
It is famous medicine scholar professor Ye Juquan think " pollen is a kind of most comprehensive diet good food of nutrition, have strong physical strength, increase spirit,
The effects of eliminating fatigue, beauty and anti-aging rapidly ".Particularly, it has following several functions: 1, enhancing human body comprehensive and exempt from
Epidemic disease function.The phagocytosis activity of pollen polysaccharide energy activating macrophage improves human resistance to disease.It builds up health, eliminates fatigue, mentions
High immunity of organisms.External many sportsmen often eat pollen, and pollen is formally set to the guarantor of China sportsman by the State Physical Culture and Sports Commission
Health food.2, anti-aging, beautification function.The cosmetics of Bee Pollen category trophism, VE, superoxide dismutase in pollen
(SOD), the ingredients such as selenium can moisten nutrition skin, restore the elastic and bright and clean of skin.Inositol in pollen can make white hair blackening, take off
Hair is gradually given birth to, and keeps hair pitch-black beautiful.3, brain cardiovascular disease is prevented and treated.Flavone compound in pollen can effectively clear blood vessel
Fatty deposition on wall, to play a part of to soften blood vessel and reducing blood lipid.
Currently, seldom to the application on honeycomb in the treatment otitis, and treat ineffective.
Summary of the invention
The present invention overcomes the deficiencies of the prior art and provide a kind of drug and preparation method thereof for treating otitis media suppurative.
Purpose is the drug that honeycomb is used to prepare to treatment otitis media suppurative, and effectively improves therapeutic effect.
In order to solve the above technical problems, the technical scheme adopted by the invention is as follows.
A kind of drug for treating otitis media suppurative, the raw material including following parts by weight: 1-5 parts of honeycomb, 3-8 parts of borneol,
3-8 parts of alum.
Preparation method the following steps are included:
A) it is ground into powdery after freezing honeycomb at -18 DEG C ~ -20 DEG C, the water of 1-2.5 times of honeycomb weight is added, is sufficiently mixed
Afterwards at -4 DEG C ~ 0 DEG C after ultrasound 1-2h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated at 20-25 DEG C
0.5-1.5h obtains mixture.
B) mixture is placed under natural light after standing to volume reduction 50-70% and is sealed, the mixture of sealing is quiet
The drug of the treatment otitis media suppurative is obtained after setting 10-20 days.
Preferably, further include the raw material of following parts by weight: 2-4 parts of mountain Cape jasmine, 1-3 parts of indigo naturalis, 1-3 parts of the coptis, campanulaceae
1-5 parts.
It preferably, further include 3-10 parts of vinegar；The preparation method include step a) by honeycomb at -18 DEG C ~ -20 DEG C
It is ground into powdery after freezing, vinegar is added, after being sufficiently mixed at -4 DEG C ~ 0 DEG C after ultrasound 1-2h, borneol and alum is added, then
It is secondary be sufficiently mixed after, be ultrasonically treated 0.5-1.5h at 20-25 DEG C, obtain mixture.
More preferably, the vinegar is the rice vinegar of solid state fermentation preparation.
More preferably, the honeycomb is Hornet nest.
Honeycomb is containing volatile oil (nidus vespae oil), beeswax, resin, protein, iron, calcium etc..Honeycomb preparation, which has, promotes body thin
The effect of born of the same parents' immune function, also to staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, shigella dysenteriae, typhoid bacillus and common
Proteus etc. has very strong restraint；Also there is inhibiting effect to fungies such as aspergillus fumigatus, aspergillus flavus, eggplant sickle bacterium, leukonids.
The chemical component of honeycomb is very complicated, mainly contains beeswax, resin, grease, pigment, tannin, carbohydrate, organic acid, fatty acid, glucoside
Class, enzyme and insect hormone etc..Nidus vespae aqueous extract can inhibit acute and chronic inflammation, and analgesic activity is then mainly to chronic
Pain is effective.Its propyl alcohol and alcohol, ether extract have significant hemostasis effect；Water extract can be obviously promoted rats in vitro thrombus
It is formed, and can increase the adhesion rate of blood platelet.Honeycomb oil can ascarifuge, tapeworm.Extract has decompression, expansion blood vessel and heart tonifying to make
With, and can anticancer, antibacterial and cooling.Pyogenic infection, acute mastitis, nerve skin are treated with honeycomb or through appropriate compatibility
A variety of diseases such as scorching, toothache.
But the quality relative rigid of honeycomb, honeycomb is that beeswax secreted by wax gland of the worker bee with itself is built, in honeycomb
During use, the footprint of bee activity slowly penetrates into honeycomb, the various active object of the pollen taken back and honeybee secretion
Matter is also slowly penetrated into honeycomb, and honeycomb outer wall firmly wraps up internal active constituent, the present invention by first by honeycomb compared with
It is rapidly frozen under low cryogenic temperature, the active constituent in honeycomb is not easy to lose, and later by the effect of ultrasonic wave, makes to be dissolved in water
Honeycomb particle broken wall is mutually collided under the mild action of external force, not easy in inactivation while active constituent is released, addition
Borneol and alum and honeycomb compatibility reinforce the bactericidal effect to suppurative bacterium, and are acted on by ultrasonic wave and sufficiently being combined, natural
The external condition of light is relatively mild, and the light quantum in natural light can slowly activate organic acid in honeycomb, fatty acid and insect to swash
The long response time of element, the final drug that improves is to the therapeutic effect of otitis media suppurative.After further using vinegar to honeycomb dissolution,
The toxicant contained in honeycomb can be neutralized, improve it and prepare Drug safety.
Compared with prior art the invention has the following advantages: the present invention by crushing honeycomb under freezing conditions
And low temperature ultrasonic acts on, do not destroy effective component in honeycomb it is active under the premise of discharge completely, in conjunction with borneol and alum
Synergic remove, hence it is evident that improve drug treatment otitis media suppurative therapeutic effect.It is demonstrated experimentally that of the present invention
Treat otitis media suppurative drug its can 98% or more killing suppurative bacterium, significant effect be higher than natural honeycomb sterilization
Rate.And cure rate can reach 84% or more during treating otitis media suppurative.
Specific embodiment
The technical solution that the present invention will be described in detail is come with specific embodiment below:
Embodiment 1
A kind of drug for treating otitis media suppurative, including following raw material: honeycomb 1kg, borneol 3kg, alum 4kg；Preparation method
Include the following steps.
A) be ground into powdery after freezing honeycomb at -18 DEG C, 2kg water be added, after being sufficiently mixed at -4 DEG C ultrasound 1h
Afterwards, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated 1.5h at 25 DEG C, obtains mixture.
B) mixture is placed under natural light after standing to volume reduction 50% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 15 days.
Embodiment 2
A kind of drug for treating otitis media suppurative, including following raw material: honeycomb 5kg, borneol 5kg, alum 8kg；Preparation method
Include the following steps.
A) it is ground into powdery after freezing honeycomb at -20 DEG C, 2.5kg water is added, it is ultrasonic at -2 DEG C after being sufficiently mixed
After 2h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated 1h at 20 DEG C, obtains mixture.
B) mixture is placed under natural light after standing to volume reduction 70% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 20 days.
Embodiment 3
A kind of drug for treating otitis media suppurative, including following raw material: honeycomb 3kg, borneol 3kg, alum 3kg；Preparation method
Include the following steps.
A) it is ground into powdery after freezing honeycomb at -20 DEG C, 1kg rice vinegar is added, it is ultrasonic at 0 DEG C after being sufficiently mixed
After 1.5h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated 0.5h at 20 DEG C, obtains mixture.
B) mixture is placed under natural light after standing to volume reduction 60% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 10 days.
Embodiment 4
A kind of drug for treating otitis media suppurative, including following raw material: honeycomb 3kg, borneol 3kg, alum 3kg, mountain Cape jasmine 2kg,
1 kg of indigo naturalis, 3 kg of the coptis, 4 kg of campanulaceae；Preparation method includes the following steps.
A) it is ground into powdery after freezing honeycomb at -20 DEG C, 1kg rice vinegar is added, it is ultrasonic at 0 DEG C after being sufficiently mixed
After 1.5h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated 0.5h at 20 DEG C, obtains mixture.
B) mixture is placed under natural light after standing to volume reduction 60% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 10 days.
Embodiment 5
A kind of drug for treating otitis media suppurative, including following raw material: honeycomb 3kg, borneol 3kg, alum 3kg, mountain Cape jasmine 4kg,
Indigo naturalis 3kg, 1 kg of the coptis, 2 kg of campanulaceae；Preparation method includes the following steps.
A) it is ground into powdery after freezing honeycomb at -20 DEG C, 2.5kg water is added, it is ultrasonic at -2 DEG C after being sufficiently mixed
After 2h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated 1h at 20 DEG C, obtains mixture.
B) mixture is placed under natural light after standing to volume reduction 70% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 20 days.
Present invention configuration is simple, and good absorption effect is significant in efficacy, without side-effects, highly-safe, is conducive to sufferer and mitigates disease
Shape is simultaneously cured.
Treatment method: medicine-feeding is primary every two days, is cured according to patient's state of an illness weight treatment time length that (varies with each individual).
Clinical trial:
1, Miss Cheng, female, 3 years old, symptom: otitis media acuta, ear-drum is complete, and ear canal is red and swollen, implements 5 healings.
2, Mr. Li, male, 11 years old, symptom: tympanitis 3 years, ear-drum was complete, and ear canal redness, flowing water implement 6 healings.
3, Chen, male, 54 years old, symptom: tympanitis 20 years, ear-drum was complete, and ear canal festers, red and swollen, flowing water, implemented 15 times
It cures.
4, Mr. Wang, female 54 years old, symptom 1: have inflammation without hearing, implement 5 healings after the repairing of auris dextra ear-drum;Symptom 2:
Left ear tympanic member perforation, ear canal festers, red and swollen, flowing water, implements 25 healings.
The above content is combine specific preferred embodiment to the further description done of the present invention, and it cannot be said that
A specific embodiment of the invention is only limitted to this, for those of ordinary skill in the art to which the present invention belongs, is not taking off
Under the premise of from the present invention, several simple deduction or replace can also be made, all shall be regarded as belonging to the present invention by being submitted
Claims determine scope of patent protection.
Claims (8)
1. a kind of drug for treating otitis media suppurative, which is characterized in that the raw material including following parts by weight: 1-5 parts of honeycomb, ice
3-8 parts of piece, 3-8 parts of alum；
Preparation method the following steps are included:
A) it is ground into powdery after freezing honeycomb at -18 DEG C ~ -20 DEG C, the water of 1-2.5 times of honeycomb weight is added, is sufficiently mixed
Afterwards at -4 DEG C ~ 0 DEG C after ultrasound 1-2h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated at 20-25 DEG C
0.5-1.5h obtains mixture；
B) mixture is placed under natural light after standing to volume reduction 50-70% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 10-20 days.
2. a kind of drug for treating otitis media suppurative according to claim 1, which is characterized in that further include following weight
The raw material of part: 2-4 parts of mountain Cape jasmine, 1-3 parts of indigo naturalis, 1-3 parts of the coptis, 1-5 parts of campanulaceae.
3. a kind of drug for treating otitis media suppurative according to claim 1, which is characterized in that further include vinegar 3-10
Part；The preparation method includes that powdery is ground into after step a) freezes honeycomb at -18 DEG C ~ -20 DEG C, and vinegar is added, fills
Divide after mixing and after ultrasound 1-2h, borneol and alum is added at -4 DEG C ~ 0 DEG C, it is ultrasonic at 20-25 DEG C after being sufficiently mixed again
0.5-1.5h is handled, mixture is obtained.
4. a kind of drug for treating otitis media suppurative according to claim 3, which is characterized in that the vinegar is solid
The rice vinegar of state fermentation preparation.
5. a kind of drug for treating otitis media suppurative according to any one of claims 1-4, which is characterized in that described
Honeycomb be Hornet nest.
6. a kind of preparation method for treating otitis media suppurative drug as described in claim 1, which is characterized in that including following
Step:
A) it is ground into powdery after freezing honeycomb at -18 DEG C ~ -20 DEG C, the water of 1-2.5 times of honeycomb weight is added, is sufficiently mixed
Afterwards at -4 DEG C ~ 0 DEG C after ultrasound 1-2h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated at 20-25 DEG C
0.5-1.5h obtains mixture；
B) mixture is placed under natural light after standing to volume reduction 50-70% and is sealed, the mixture of sealing is stood
The drug of the treatment otitis media suppurative is obtained after 10-20 days.
7. a kind of preparation method for treating otitis media suppurative drug according to claim 6, which is characterized in that a) by bee
Nest is ground into powdery after freezing at -18 DEG C ~ -20 DEG C, the vinegar of 1-1.5 times of honeycomb weight is added, after being sufficiently mixed -4 DEG C ~
At 0 DEG C after ultrasound 1-2h, borneol and alum is added, after being sufficiently mixed again, is ultrasonically treated 0.5-1.5h at 20-25 DEG C, obtains
To mixture.
8. a kind of preparation method for treating otitis media suppurative drug according to claim 7, which is characterized in that described
Vinegar is the rice vinegar of solid state fermentation preparation.
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