CN108935487B - Combined fungicide containing benziothiazolinone and isotianil - Google Patents
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- CN108935487B CN108935487B CN201811139294.0A CN201811139294A CN108935487B CN 108935487 B CN108935487 B CN 108935487B CN 201811139294 A CN201811139294 A CN 201811139294A CN 108935487 B CN108935487 B CN 108935487B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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Abstract
The invention discloses a composite bactericide containing benziothiazolinone and isotianil, which comprises active ingredients benziothiazolinone, isotianil and auxiliary ingredients, wherein the mass ratio of benziothiazolinone to isotianil is 1-80: 1-80. The composite bactericide can be applied to preventing and treating rice blast and bakanae disease, has obvious synergistic effect, delays the drug resistance of pathogenic bacteria, has long duration, reduces the times and dosage of drug administration, and reduces the use cost. The composite bactericide can be used for preventing and treating diseases such as rice blast, bakanae disease of rice and the like, and has obvious effect.
Description
Technical Field
The invention relates to the field of agricultural disease control, in particular to a composite bactericide containing benziothiazolinone and isotianil.
Background
Thiothiazolinone (Benziothiazolinone) is a heterocyclic fungicide developed by great Huate scientific and technical industries, Inc. in Shanxi. The molecular formula is as follows: c7H5NOS, chemical name: 1,2 benzisothiazolin-3-one.
The benziothiazolinone is a high-efficiency, low-toxicity and broad-spectrum bactericide, and can destroy cell membrane proteins and synthesis systems of pathogenic bacteria, so that the reproduction of the pathogenic bacteria is inhibited, the metabolism of pathogenic bacteria cells is interfered, the physiological disorder of the pathogenic bacteria is caused, and the pathogenic bacteria die. The compound has good control effect on various crop diseases caused by bacteria and fungi, and is very safe to crops and environment, low in toxicity and free of residues.
Isotianil (isotianil), a compound belonging to the isothiazolecarboxamide group; the molecular formula is as follows: c11H5Cl2N3An OS; chemical name: 3, 4-dichloro-N- (2-cyanophenyl) -5-isothiazolecarboxamide. Isotianil is an isothiazole fungicide which is developed by Bayer and Sumitomo chemistry together for preventing and controlling rice blast. It is characterized in that it does not have an antibacterial effect on pathogenic bacteria, but achieves the aim of resisting the rice blast by exciting the natural defense mechanism of the rice to the rice blast. Bayer company indicates that this is the first example of an active ingredient with low use level, which has an effect of inducing resistance, and that this environmentally friendly product is very suitable for use in the process of rice growth, in addition to a certain insecticidal activity.
The rice blast caused by the ascomycete Magnaporthe grisea (Hebert) Barr (non-sexual: Pyricularia grisea sacc.) is one of the most devastating diseases in rice production and is also a worldwide fungal disease. It occurs throughout the rice growth period, common in almost all production areas; especially in climatic zones with moderate temperature, cloudy days and high humidity, rice blast occurs frequently. The pandemic of rice blast often causes large-area yield reduction and even loss of rice in large areas, greatly affects the yield and the quality of crops, and has great influence on rice production. The three diseases of rice are called as rice sheath blight disease and bacterial leaf blight disease. In China, rice areas occur, particularly mountainous areas and hilly areas with little sunlight and long fog and dew duration. In epidemic years, the yield is generally reduced by 10-20%, the weight is 40-50%, and even the crop is no longer acceptable.
In order to achieve high yield and harvest of rice, the inventor deeply explores and researches and expects to invent a high-efficiency and environment-friendly rice blast control agent. Through a large number of experiments, the inventors invented the benziothiazolinone and isotianil bactericidal composition. The composition has high efficiency, low toxicity and long lasting period, and is a preferred medicament for rice production.
Disclosure of Invention
The invention aims to: the synergistic bactericidal composition containing the benziothiazolinone and the isotianil has an obvious control effect and is low in dosage. The composition disclosed by the invention is discovered through a compounding and screening experiment, has obvious effects on rice blast and rice bakanae disease, is obviously superior to a single-dose effect, and can reduce the using amount of pesticides. The invention adopts the following technical scheme:
a composite bactericide containing benziothiazolinone and isotianil is characterized in that the composition contains active ingredients of benziothiazolinone and isotianil.
The composite bactericide is characterized in that the mass ratio of the benziothiazolinone to the isotianil is 1-80:1-80, preferably the mass ratio of 1-70: 1-70.
The bactericidal composition takes benziothiazolinone and isotianil as main active ingredients, and can be prepared into any solid or liquid preparation allowable on pesticides together with necessary auxiliary ingredients such as pesticide auxiliary agents, fillers or solvents. Such compositions can be prepared in a known manner by mixing the active ingredients benziothiazolinone and isotianil with suitable auxiliary ingredients. The solid form comprises wettable powder, seed treatment dry powder, seed treatment dispersible powder, granules and water dispersible granules, and the liquid form comprises suspending agent, suspending emulsion, microcapsule suspending agent, seed treatment microcapsule suspending agent and suspension seed coating agent.
The auxiliary components of the composition of the present invention include wetting agents, dispersants, emulsifiers, cosurfactants, thickeners, solvents, cosolvents, antifreezes, disintegrants, preservatives, stabilizers, film forming agents, encapsulating agents, pH pH modifiers, antifoaming agents, colorants, fillers, and the like, and other known substances useful for stabilizing or exerting active ingredients in a formulation, and are various components that are generally used in preparation or are agriculturally acceptable to use, and are not particularly limited, and specific components and amounts thereof are determined by experiments as needed.
The wetting agent is selected from E0/P0 block polyether, fatty alcohol-polyoxyethylene ether, fatty alcohol ethoxy compound, tallow ethoxy ammonium salt, alkyl naphthalene sulfonate, fatty alcohol-polyoxyethylene ether sulfate and acyl glutamate.
The dispersing agent is selected from condensed naphthalene sulfonate, sodium phenolsulfonic acid condensate, sodium methyl naphthalene sulfonate formaldehyde condensate, sodium lignosulfonate, sodium methylene dinaphthalenesulfonate, acrylic acid homopolymer sodium salt, high-molecular polycarboxylate, dioctyl sulfosuccinic acid sodium salt, Eo/Po block polyether and maleic acid-acrylic acid copolymer sodium salt.
The emulsifier is selected from alkylphenol ethoxylates, benzyl phenol polyoxyethylene ether, phenethylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, phenethylphenol polyoxyethylene ether polyoxypropylene ether, fatty amine polyoxyethylene ether, sesame oil ethylene oxide adduct and derivatives thereof, polyol fatty acid ester and ethylene oxide adduct thereof, alkylbenzene sulfonate, alkyl succinate sulfonate, alkyl diphenyl ether sulfonate, naphthalenesulfonic acid formaldehyde condensate, fatty alcohol sulfate, alkylphenol polyoxyethylene ether sulfate, aralkyl phenol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, fatty acid polyoxyethylene ester phosphate, alkylamine polyoxyethylene ether phosphate, alkyl phosphate, alkylphenol polyoxyethylene ether formaldehyde condensate, aralkyl phenol polyoxyethylene ether formaldehyde condensate, polyoxyethylene ether phosphate, polyoxyethylene ether formaldehyde condensate, One or more of a diphenol polyoxyethylene ether formaldehyde condensate, a polyoxyethylene polyoxypropylene block copolymer, an alkyl naphthalene sulfonic acid formaldehyde condensate, a phenol formaldehyde condensate sulfonate, an alkyl phenol polyoxyethylene ether formaldehyde condensate sulfate, a methyl cellulose and a derivative thereof, an alkyl ammonium salt, an amino alcohol fatty acid derivative, a polyamine fatty acid derivative, a quaternary ammonium salt, a tallow ethoxylated amine salt, an alkyl naphthalene sulfonate, an amino acid, an amine oxide, a betaine, a fatty alcohol polyoxyethylene ether sulfate and an acyl glutamate.
The cosurfactant is selected from n-butanol, isobutanol and n-octanol.
The thickener is selected from xanthan gum, magnesium aluminum silicate, sodium carboxymethylcellulose, sodium starch phosphate, sodium starch octenyl succinate and polyvinyl alcohol.
The solvent is one or more selected from xylene, rosin-based vegetable oil, methyl oleate and heavy aromatic solvent oil.
The cosolvent is selected from cyclohexanone, N-dimethyl acetamide and N, N-dimethyl formamide.
The antifreeze is selected from ethylene glycol, propylene glycol, glycerol, isopropanol and urea.
The film forming agent is selected from polyvinyl alcohol, polyvinyl acetate, polyethylene glycol methacrylate, hydroxymethyl cellulose, gum arabic, xanthan gum, starch and other high molecular polymers with cohesiveness and film forming property.
The capsule wall material used by the encapsulating agent is polyurea resin which is prepared by the interfacial polymerization reaction of isocyanate monomer and polyol or polyamine; the isocyanate includes toluene diisocyanate, 4-diphenylmethane diisocyanate, polyphenyl polymethylene polyisocyanate and the like.
The pH acid-base regulator is one or more selected from citric acid, glacial acetic acid, hydrochloric acid, ammonia water, triethylamine, triethanolamine and diethylenetriamine, and the required dosage is that the pH value of the final product is regulated to be in a stable range.
The disintegrating agent is selected from sodium chloride, ammonium sulfate, sodium sulfate, and soluble starch.
The antiseptic is selected from the group consisting of kaempferol, formaldehyde, phenyl salicylate, sodium benzoate, butyl p-hydroxybenzoate, and potassium sorbate.
The stabilizer is selected from epoxidized soybean oil, epichlorohydrin, triphenyl phosphite, glycidyl ether or pentaerythritol.
The defoaming agent is selected from organic silicon defoaming agent and polyether defoaming agent.
The colorant is selected from iron oxide, titanium oxide and azo dye.
The filler is selected from kaolin, diatomite, talcum powder, light calcium carbonate and white carbon black.
The water is tap water, deionized water or distilled water.
The weight percentage of the benziothiazolinone and the isotianil in the preparation is 2-80%.
The bactericidal composition provided by the invention is applied to preventing and treating rice blast and rice bakanae disease, has a remarkable effect, is obviously superior to a single-dose effect, and can reduce the using amount of pesticides.
The dosage of the bactericidal composition is 15-30g a.i./hm2。
The invention has the following advantages:
1. the bactericidal composition containing the benziothiazolinone and the isotianil has obvious synergistic effect;
2. the bactericidal composition containing benziothiazolinone and isotianil has the advantages of small dosage and long lasting period;
3. the bactericidal composition containing benziothiazolinone and isotianil is not easy to generate resistance;
4. the bactericidal composition containing the benziothiazolinone and the isotianil is green and safe, and is an excellent medicament for producing pollution-free food.
Detailed Description
The technical scheme and the technical effect of the invention are further explained by combining specific embodiments.
The percentages stated in the present invention are percentages by weight, but the embodiments of the invention are not limited to the ranges stated in the examples.
The experiment adopts a method combining indoor toxicity measurement and field test. Firstly, the indoor toxicity is measured, a proper proportion is screened, and then the field test is carried out on the basis.
Example 1 indoor toxicity assay of Saisenone and Isotianil on Rice blast
The method for measuring the indoor bacteriostatic effect comprises the following steps: the growth rate method is adopted to determine the inhibition effect of the bactericidal composition on rice blast germs. Taking hypha blocks with the diameter of 5mm from the edges of wheat take-all disease colonies cultured for 4 days on a PDA culture medium, respectively inoculating the hypha blocks on PDA culture medium plates containing bactericides with different concentrations, culturing at constant temperature of 28 ℃, taking a plate without a medicament as a blank control, measuring the diameter of each treated colony after 4 days, and calculating the inhibition percentage of the medicament on the growth of the hypha. The inhibition medium concentration (EC) of the bactericide on the rice blast is calculated by carrying out regression analysis on the logarithm of each treatment dosage and the probability value of the hypha growth inhibition rate50) Then, the cotoxicity coefficient (CTC) was calculated by the Sun Yunpei method.
When the CTC is less than or equal to 80, the composition shows antagonism, when 80< CTC is less than 120, the composition shows additive action, and when the CTC is more than or equal to 120, the composition shows synergistic action.
Measured virulence index (ATI) ═ standard agent EC50Test drug efficacy EC50)*100；
Theoretical virulence factor (TTI) ═ virulence index of a agent + virulence index of B agent + percent of a in the mixture;
co-toxicity coefficient (CTC) ═ mix observed virulence index (ATI)/mix theoretical virulence index (TTI) ] + 100.
The results of indoor toxicity measurement of the bactericidal composition containing benziothiazolinone and isotianil on rice blast are shown in table 1.
TABLE 1 indoor toxicity assay for rice blast by different proportions of benziothiazolinone and isotianil
As can be seen from Table 1, when the mixing ratio of the benziothiazolinone to the isotianil is 80:1-1:80, the co-toxicity coefficient (CTC) is greater than 120, and good synergistic effect is shown.
Example 2 indoor toxicity determination of Thiazone and Isotianil for Rice bakanae disease
The method for measuring the indoor bacteriostatic effect comprises the following steps: the growth rate method is adopted to determine the inhibition effect of the bactericidal composition on the rice bakanae disease. Taking hypha blocks with the diameter of 5mm from the colony edge of the rice bakanae disease cultured on a PDA culture medium for 4 days, respectively inoculating the hypha blocks to PDA culture medium flat plates containing bactericides with different concentrations, culturing at constant temperature of 28 ℃, taking a flat plate without the medicament as a blank control, measuring the diameter of each treated colony after 4 days, and calculating the inhibition percentage of the medicament on the growth of the hypha. The inhibition median concentration (EC) of the bactericide on the rice bakanae disease is calculated by carrying out regression analysis on the logarithm of each treatment dosage and the probability value of the hypha growth inhibition rate50) Then, the cotoxicity coefficient (CTC) was calculated by the Sun Yunpei method.
When the CTC is less than or equal to 80, the composition shows antagonism, when 80< CTC is less than 120, the composition shows additive action, and when the CTC is more than or equal to 120, the composition shows synergistic action.
Measured virulence index (ATI) ═ standard agent EC50Test drug efficacy EC50)*100；
Theoretical virulence factor (TTI) ═ virulence index of a agent + virulence index of B agent + percent of a in the mixture;
co-toxicity coefficient (CTC) ═ mix observed virulence index (ATI)/mix theoretical virulence index (TTI) ] + 100.
The toxicity test results of the bactericidal composition containing benziothiazolinone and isotianil on rice bakanae disease in the room are shown in table 2.
TABLE 2 indoor toxicity determination of different proportions of benziothiazolinone and isotianil for rice bakanae disease
As can be seen from Table 2, when the mixing ratio of the benziothiazolinone to the isotianil is 80:1-1:80, the co-toxicity coefficient (CTC) is greater than 120, and good synergistic effect is shown.
Example 3 field efficacy experiment for preventing and treating Pyricularia oryzae
1. Experimental treatment: the experiment is respectively provided with three treatment concentrations according to different components, and the reference medicaments are respectively a pesticide single-dose 30% isotianil suspending agent, a 5% benziothiazolinone suspending agent and a blank clear water reference.
2. The test method comprises the following steps: 66.7m per cell2Repeating the steps for 3 times; the method for investigating before and after pesticide application comprises the following steps: randomly sampling 5 points in the experimental treatment area, grading the disease condition according to the relevant standards of the national field test, and calculating the prevention effect. The results are shown in Table 5:
TABLE 3 drug effect test of rice blast by different proportions of benziothiazolinone and isotianil
As can be seen from the table 3, the fungicidal combination of benziothiazolinone and isotianil has better control effect on rice blast than that of a control medicament at a relatively low dosage, and the composition shows excellent synergistic effect and long lasting period under the condition of lower dosage than that of a single dosage.
Example 4 field efficacy experiment for preventing and treating bakanae disease of rice
1. Experimental treatment: the experiment is respectively provided with three treatment concentrations according to different components, and the reference medicaments are respectively a pesticide single-dose 30% isotianil suspending agent, a 5% benziothiazolinone suspending agent and a blank clear water reference.
2. The test method comprises the following steps: 66.7m per cell2Repeating the steps for 3 times; the method for investigating before and after pesticide application comprises the following steps: randomly sampling 5 points in the experimental treatment area according toAnd (4) grading the disease condition according to the relevant national field test standards, and calculating the prevention effect. The results are shown in Table 6:
TABLE 4 efficacy test of different proportions of benziothiazolinone and isotianil on rice bakanae disease
As can be seen from the table 4, the bactericidal combination of benziothiazolinone and isotianil has better control effect on rice bakanae disease than that of a control medicament at a relatively low dosage, and the composition shows excellent synergistic effect and long lasting period under the condition of lower dosage than that of a single dosage.
Claims (6)
1. A combined fungicide containing benziothiazolinone and isotianil is characterized in that the composition contains active ingredients of benziothiazolinone and isotianil, wherein the mass ratio of benziothiazolinone to isotianil is 1-80: 1-80.
2. The combination fungicide according to claim 1, characterized in that the preferred mass ratio of benziothiazolinone and isotianil is 1-70: 1-70.
3. The germicidal composition as claimed in claim 1 or 2, wherein: the pesticide composition is prepared into any formulation allowed in pesticides by taking benziothiazolinone and isotianil as main active ingredients and pesticide auxiliary agents, fillers or solvents.
4. The germicidal composition of claim 3, wherein: the weight percentage of the benziothiazolinone and the isotianil in the preparation is 2-80%.
5. The bactericidal composition according to any one of claims 1 to 3, wherein the bactericidal composition is used for preventing and treating rice blast and bakanae disease of rice.
6. The bactericidal composition of claim 4 is used for preventing and treating rice blast and bakanae disease of rice.
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| CN113439752A (en) * | 2021-06-28 | 2021-09-28 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and benziopyrazine and application |
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Non-Patent Citations (3)
| Title |
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| 3,4-二氯异噻唑-5-甲酰胺衍生物的合成及生物活性;陈晓燕等;《农药学学报》;20130415;第15卷(第2期);140-144 * |
| 双氯磺草胺、异噻菌胺两原药将获我国首登;杨光;《农药市场信息》;20180411(第9期);40 * |
| 高效广谱杀菌剂噻霉酮;余露;《农药市场信息》;20120511(第12期);39 * |
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