CN108904303A - Fullerene-compound cosmetic material of essential oil-polypeptide and preparation method thereof - Google Patents
Fullerene-compound cosmetic material of essential oil-polypeptide and preparation method thereof Download PDFInfo
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- CN108904303A CN108904303A CN201810934943.XA CN201810934943A CN108904303A CN 108904303 A CN108904303 A CN 108904303A CN 201810934943 A CN201810934943 A CN 201810934943A CN 108904303 A CN108904303 A CN 108904303A
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- essential oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention discloses a kind of fullerene-essential oil-polypeptide compound cosmetic material preparation methods, including：A. fowler ene compositions are dissolved in organic solvent, add monohydric alcohol or unitary alcohol solution thereto, so that particle is precipitated in fullerene crystallization；It is centrifuged, filtered, it is dry, obtain fullerene powder；Under nitrogen protection, fullerene powder is dissolved in essential oil, stirs, obtains fullerene essential oil solution；B. under nitrogen protection, above-mentioned essential oil solution is mixed with the unitary alcoholic solution of interfacial agent, is stirred, freeze-drying obtains the fullerene powder of essential oil and interfacial agent double-coating；C. the fullerene powder being wrapped by is dissolved in distilled water, polypeptide agar is added, be freeze-dried, grinding disperses to get fullerene-compound cosmetic material of essential oil-polypeptide.Cosmetic material of the invention, antibacterial anti-inflammatory, repair skin, absorb free radical, it is anti-oxidant, promote skin cell metabolism and in terms of have remarkable efficacy.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of fullerene-compound cosmetic material of essential oil-polypeptide and
Preparation method.
Background technique
Fullerene is American scientist Smalley, Curl in 1985 and British scientist Kroto discovery
(H.W.Kroto,J.R.Heath,S.C.O'Brien,R.F.Curl,R.E.Smalley,C60:
Buckminsterfullerene, Nature, 1985.318,162-163) a kind of carbon with special hollow molecules structure it is same
Plain obform body.Nobel's chemistry was awarded at 1996 because of initiative work in fullerene research by three scientists
Prize.The Charles N.McEwen discovery fullerene absorption with super strength of E.I.Du Pont Company and the ability for eliminating free radical, thus
The good reputation for imparting fullerene " free radical sponge ", due to fullerene strength absorb free radical, delaying cell aging the effect of,
Through having played huge effect in fields such as cosmetics, bio-pharmaceuticals.The free radical (active oxygen) of human skin be cause wrinkle,
The blasting fuse of all kinds of skin problems such as obscure, color spot, drying.High new component fullerene has brilliant bioactivity, can be as sea
Silk floss water suction generally absorbs and eliminates free radical, to cut off the source of skin problem, calls the plain face of young health back again, and mention
Itself resistance of high skin.
Since fullerene molecule itself is in water without solubility, the realization of application will be leaned on using hydrophilicity macromolecule material
It material cladding and is realized in Fullerene Carbon cage surface modification hydrophilic functional group.The side coated using hydrophilic high molecular material
It is to mix the aromatic hydrocarbon solution of fullerene with the ethanol solution of polyvinylpyrrolidone that method, which is reported at most, evaporates solvent
Obtain the fullerene water water-soluble pulverulent of brown color PVP cladding.But such product inevitably has the residual of aromatic hydrocarbon solvent, shadow
Ring application of the target product in cosmetics.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of fullerene-compound cosmetic material of essential oil-polypeptide, the makeups
Product raw material has both the multi-functional of fullerene, essential oil and polypeptide, antibacterial anti-inflammatory, repair skin, absorb free radical, it is anti-oxidant,
Skin cell metabolism and anti-aging etc. is promoted to have remarkable efficacy.
In order to solve the above-mentioned technical problems, the present invention provides the preparations of fullerene-essential oil-polypeptide compound cosmetic material
Method includes the following steps：
A. fowler ene compositions are dissolved in organic solvent in saturated solution ratio, add unitary into the organic solvent
Alcohol or unitary alcohol solution, so that particle is precipitated in fullerene crystallization；It is centrifuged, filtered, it is dry, obtain fullerene powder；In nitrogen
Under protection, obtained fullerene powder is dissolved in essential oil, stirs, obtains fullerene essential oil solution；The organic solvent can be used
The common organic good solvent of fullerene, such as toluene.
B. under nitrogen protection, above-mentioned essential oil solution is mixed with the unitary alcoholic solution of interfacial agent, is stirred, freezing is dry
It is dry, obtain the fullerene powder of essential oil and interfacial agent double-coating；
C. the fullerene powder being wrapped by is dissolved in distilled water, polypeptide agar is added, be freeze-dried, grinding, dispersion to get
It is of the present invention to contain fullerene-compound cosmetic material of essential oil-polypeptide.
Preferably, by percentage to the quality, the dosage of fowler ene compositions is 0.05wt%-8wt%, and the dosage of polypeptide is
The dosage of 0.05wt%-8wt%, interfacial agent are 5wt%-95wt%, remaining is essential oil.It is furthermore preferred that fullerene combines
The dosage of object is 0.05wt%-2wt%, and the dosage of polypeptide is 0.05wt%-3wt% essential oil, and the dosage of interfacial agent is
20wt%-95wt%, remaining is essential oil.
Preferably, the fowler ene compositions are selected from following at least one：Fullerene C20, fullerene C70, fullerene
C76, fullerene C78, fullerene C84, fullerene C90 and embedded fullerene, wherein Fullerene C20 purity >=99.5%, fowler
Alkene C70 purity >=99%.
Preferably, which is characterized in that the essential oil is selected from following at least one：Rosa Damascana, borneol essential oil, jasmine essence
Oil, Lavender, chamomile essential oil, Geranium Essential, osmanthus essential oil, peony essential oil, marigold essential oil, laurin oil, gold
Honeysuckle flower essential oil, violet essential, tea tree ethereal oil, Peppermint essential oil, needle juniper essential oil, spearmint essential oil, ginseng essential oil, rosemary essence
Oil, cinnamon essential oil, Bergamot, grapefruit essential oil, lemon, sweet orange oil, lime essential oil, bitter orange essential oil, red mandarin orange essence
Oil, clove oil, almond essential oil, cardamom essential oil.
Preferably, the interfacial agent is selected from following at least one：Polyvinylpyrrolidone K15, polyvinylpyrrolidine
Ketone K17, polyvinylpyrrolidone K25, PVP K30, PVP K90.
Preferably, the polypeptide agar is polypeptide or polypeptide derivative, is selected from following at least one：Palmityl tripeptides-
1, Matrixyl -4, Argireline, acetyl group octapeptide -3, palmityl tetrapeptide -7, -1 copper of tripeptides, carnosine, nonapeptide -1, second
Acyl group tetrapeptide -5, myristoyl pentapeptide -4.
Preferably, in step a, fullerenic particles are dried using vacuum oven, the temperature of the vacuum oven
It is 60 DEG C -200 DEG C, wherein being advisable with 80 DEG C -150 DEG C of range；Drying time is 4h-24h, wherein the range with 5h-12h is
Preferably；Mixing time of the fullerenic particles in essential oil is 2h-48h, wherein the range with 3h-8h is advisable.
Preferably, in the fullerene essential oil solution, the weight ratio (F/M) of fullerene (F) and essential oil (M) are 0.00001
~0.0015；In the unitary alcoholic solution of the interfacial agent, interfacial agent (P) and the weight ratio (P/Q) of monohydric alcohol (Q) are
0.008~0.6；The weight ratio of the unitary alcoholic solution (P-Q) of the fullerene essential oil solution (F-M) and interfacial agent is 0.05
~4.
Preferably, the fullerene powder being wrapped by is dissolved in distilled water, after polypeptide agar is added, is pressurizeed by molecules align device
And Freeze Drying Technique is used, it is fabricated to the pure biological raw material of fullerene cosmetics.The fullerene powder being wrapped by and polypeptide
The weight ratio (F-M-P/W) of agar compound tense, fullerene powder (F-M-P) and polypeptide (W) agar is 0.1-100.
In the present invention, fowler ene compositions through essential oil molecule coat, interfacial activity agent molecule be coated with and with polypeptide agar
Compatibility, all operating processes all carry out under conditions of starvation.
In addition, the present invention also provides the compound cosmetics of fullerene-essential oil-polypeptide that aforementioned preparation process is prepared are former
Material, the cosmetic material closed preservation of shading under low temperature or freezing conditions, the shelf-life is -20 days 7 days after opening.
The beneficial effects of the present invention are：
Fullerene of the invention-compound the cosmetic material of essential oil-polypeptide, has both the multiple function of fullerene, essential oil and polypeptide
Can, antibacterial anti-inflammatory, repair skin, absorb free radical, it is anti-oxidant, promote skin cell metabolism and in terms of have
Remarkable efficacy.Compared with prior art, the link for increasing essential oil molecule cladding, on the basis of solving problem of solvent residual
Also the effect of effectively increasing essential oil.
Detailed description of the invention
Fig. 1 is fullerene of the invention-essential oil-polypeptide compound cosmetic material microstructure schematic diagram；
Wherein, F is fowler ene compositions, and M is essential oil strand, and P is interfacial agent, and W is polypeptide or polypeptide derivative.
Specific embodiment
Method of the invention is illustrated below by specific embodiment, so that technical solution of the present invention is easier to manage
Solution is grasped, but the present invention is not limited thereto.Experimental method described in following embodiments is unless otherwise specified conventional side
Method；The reagent and material commercially obtain unless otherwise specified.
Embodiment 1
The present embodiment provides a kind of fullerene-compound cosmetic material of essential oil-polypeptide, the raw material of the cosmetic material includes
0.05g fullerene C60, 10g polyvinylpyrrolidone K17,0.5g nonapeptide -1,2g essential oil.
The fullerene of the present embodiment-compound cosmetic material of essential oil-polypeptide is prepared by following method：
Weigh 0.32g fullerene C60It pours into 100mL toluene solution, under the conditions of room temperature, nitrogen protection, stirs 12 hours,
So that fullerene is dissolved completely in toluene, deep purple solution is obtained.50mL anhydrous methanol is measured, is added in above-mentioned solution, is taken out
Filter, is repeatedly washed with anhydrous methanol, obtains pretreated fullerene C60；
Weigh the fullerene C that 0.1g is obtained60It is added in 100mL refined jasmine oil, stirred under nitrogen atmosphere 16 hours, obtains rich
Strangle alkene C60Refined jasmine oil solution weighs 20g polyvinylpyrrolidone K17 and is slowly dissolve into anhydrous methanol reagent, nitrogen protection
Lower stirring 8 hours, obtains the methanol solution of polyvinylpyrrolidone K17.
By fullerene C60Refined jasmine oil solution is added in the methanol solution of polyvinylpyrrolidone K17, under nitrogen protection
Continue stirring 12 hours, ultrasound continues stirring 12 hours after 2 hours.Freeze-drying process is carried out later, obtains fullerene C60Jasmine
Essential oil-polyvinylpyrrolidone K17 composite powder.
It weighs 12.05 grams of above-mentioned composite powders to be dissolved in 100mL distilled water, addition nonapeptide -1 0.5g, under nitrogen protection
Stirring 4 hours, freeze-drying, obtains target fullerene-compound cosmetic material of essential oil-polypeptide.
Attached drawing 1 shows fullerene-essential oil-polypeptide compound cosmetic material microstructure schematic diagram, by figure it is found that
Fullerene molecule is coated by essential oil strand, interfacial activity agent molecule and peptide molecule chain.
Fullerene of the invention-compound the cosmetic material of essential oil-polypeptide, has both the multiple function of fullerene, essential oil and polypeptide
Can, antibacterial anti-inflammatory, repair skin, absorb free radical, it is anti-oxidant, promote skin cell metabolism and in terms of have
Remarkable efficacy.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention
It encloses without being limited thereto.Those skilled in the art's made equivalent substitute or transformation on the basis of the present invention, in the present invention
Protection scope within.Protection scope of the present invention is subject to claims.
Claims (10)
1. fullerene-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that include the following steps：
A. fowler ene compositions are dissolved in organic solvent in saturated solution ratio, and add monohydric alcohol or monohydric alcohol is water-soluble
Liquid, so that particle is precipitated in fullerene crystallization；Through centrifugation, filtering, drying, fullerene powder is obtained；Under nitrogen protection, it will obtain
Fullerene powder is added in essential oil, and stirring obtains fullerene essential oil solution；
B. under nitrogen protection, above-mentioned essential oil solution is mixed with the unitary alcoholic solution of interfacial agent, stirring, freeze-drying,
Obtain the fullerene powder of essential oil and interfacial agent double-coating；
C. the fullerene powder of double-coating is dissolved in distilled water, polypeptide agar is added, be freeze-dried, grinding, dispersion is to get this
Contain fullerene-compound cosmetic material of essential oil-polypeptide described in invention.
2. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
It states in fullerene-compound cosmetic material of essential oil-polypeptide, by percentage to the quality, the dosage of fowler ene compositions is
0.05wt%-8wt%, the dosage of polypeptide are 0.05wt%-8wt%, and the dosage of interfacial agent is 5wt%-95wt%, remaining
For essential oil.
3. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
It states fowler ene compositions and is selected from following at least one：Fullerene C60, fullerene C70, fullerene C76, fullerene C78, fullerene
C84, fullerene C90With embedded fullerene, wherein fullerene C60Purity >=99.5%, fullerene C70Purity >=99%.
4. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
It states essential oil and is selected from following at least one：Rosa Damascana, borneol essential oil, refined jasmine oil, Lavender, chamomile essential oil, India
Certain herbaceous plants with big flowers essential oil, osmanthus essential oil, peony essential oil, marigold essential oil, laurin oil, honeysuckle essential oil, violet essential, tea tree ethereal oil,
Peppermint essential oil, needle juniper essential oil, spearmint essential oil, ginseng essential oil, Rosemary Oil, cinnamon essential oil, Bergamot, grape fruit essence
Oil, lemon, sweet orange oil, lime essential oil, bitter orange essential oil, red mandarin orange essential oil, clove oil, almond essential oil, cardamom essential oil.
5. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
It states interfacial agent and is selected from following at least one：Polyvinylpyrrolidone K15, polyvinylpyrrolidone K17, polyvinylpyrrolidine
Ketone K25, PVP K30, PVP K90.
6. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
It states polypeptide and is selected from following at least one：Palmityl tripeptides -1, Matrixyl -4, Argireline, acetyl group octapeptide -3, palm fibre
Palmitic acid acyl tetrapeptide -7, -1 copper of tripeptides, carnosine, nonapeptide -1, acetyl group tetrapeptide -5, myristoyl pentapeptide -4.
7. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that step
In rapid a, fullerenic particles are dried using vacuum oven, and the temperature of the vacuum oven is 60 DEG C -200 DEG C, dry
Time is 4h-24h；Mixing time of the fullerenic particles in essential oil is 2h-48h.
8. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
It states in fullerene essential oil solution, the weight ratio (F/M) of fullerene (F) and essential oil (M) are 0.00001~0.0015；The interface
In the unitary alcoholic solution of activating agent, the weight ratio (P/Q) of interfacial agent (P) and monohydric alcohol (Q) are 0.008~0.6；The richness
The weight ratio for strangling the unitary alcoholic solution (P-Q) of alkene essential oil solution (F-M) and interfacial agent is 0.05~4.
9. fullerene as described in claim 1-essential oil-polypeptide compound cosmetic material preparation method, which is characterized in that institute
State the fullerene powder and polypeptide agar compound tense of double-coating, the weight ratio of fullerene powder (F-M-P) and polypeptide (W) agar
It (F-M-P/W) is 0.1-100.
10. fullerene-compound the cosmetics of essential oil-polypeptide being prepared such as the described in any item preparation methods of claim 1-9
Raw material.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109464312A (en) * | 2018-12-26 | 2019-03-15 | 广州蜜妆生物科技有限公司 | A kind of skin care item odorant of natural and multi-functional |
| CN109620748A (en) * | 2018-12-25 | 2019-04-16 | 格瑞复斯（武汉）生化科技股份有限公司 | A kind of anti-wrinkle essence and preparation method thereof |
| CN113925817A (en) * | 2021-11-26 | 2022-01-14 | 刘均亮 | Skin care essence with anti-pollution effect and preparation method thereof |
| CN115429712A (en) * | 2022-09-02 | 2022-12-06 | 广东粤港澳大湾区国家纳米科技创新研究院 | Polypeptide and fullerene co-delivery nano composition, preparation method and application thereof |
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Application publication date: 20181130 |