CN108888541A - 一种皮肤护理组合物及其制备方法 - Google Patents
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Abstract
本发明公开一种皮肤护理组合物,按重量百分含量计,包括:成膜剂1%~20%、增稠剂0.5%~10%、增塑剂0.5%~10%、抑菌剂0.01%~2%、皮肤调节剂0.01%~2%及溶剂余量。本发明的皮肤护理组合物的配方搭配合理,制备成本低廉,使用方便,直接涂抹于皮肤上即可形成具有适宜强度和韧性的透明薄膜,使用舒适性好,无紧绷感,方便观察被覆盖皮肤创面的情况,以便及时治疗。所述皮肤护理组合物还具有良好的耐湿性、耐摩擦性、耐水性及抑菌性,可对皮肤起到很好的保护作用,使皮肤与外界环境隔离,防止创面炎症及受感染,降低创面进一步恶化的风险,还可防止创面水分散失,维持创面湿润,利于创面愈合,且能满足在潮湿环境中短时间使用的要求。
Description
技术领域
本发明涉及一种皮肤护理产品,尤其涉及一种皮肤护理组合物及其制备方法。
背景技术
皮肤覆盖在人体最外面,是人体最大的器官,约占人体重的15%。皮肤具有屏障作用,可以保护人体内环境的稳定,阻止外界有害物质的入侵。生活中,常有皮肤受损的情况发生,比如:烧烫伤、急慢性皮肤溃疡、划伤、擦伤及手术伤口等。皮肤受损时,由于没有了皮肤的保护,表皮以下的人体组织很容易会受外界细菌等各种不利因素的侵略,增加创面感染,从而引发创面炎症、化脓等,若处理不及时,还会造成截肢的风险。目前,市面上的皮肤护理产品都是用于改善健康皮肤外观用的化妆品,如保湿、祛痘和美白等类型的皮肤护理产品,还没有针对损伤皮肤或脆弱皮肤的护理产品。因此,亟需开发一种针对损伤皮肤或脆弱皮肤的护理产品。
发明内容
本发明的目的在于克服上述现有技术的缺点和不足,提供一种皮肤护理组合物及其制备方法,所述皮肤护理组合物涂于皮肤上后可形成具有耐摩擦性、耐湿性、耐水性、抑菌性及适宜的强度和韧性的透明薄膜,使创面与外界隔离,防止创面感染、炎症及化脓,还可防止创面水分散失,维持创面湿润,利于创面愈合。
为达到其目的,本发明所采用的技术方案为:一种皮肤护理组合物,按重量百分含量计,包括:成膜剂1%~20%、增稠剂0.5%~10%、增塑剂0.5%~10%、抑菌剂0.01%~2%、皮肤调节剂0.01%~2%及溶剂余量。
优选地,按重量百分含量计,所述皮肤护理组合物包括:成膜剂5%~10%、增稠剂3%~5%、增塑剂3%~5%、抑菌剂0.5%~1%、皮肤调节剂0.5%~1%及溶剂余量。当本发明的皮肤护理组合物按该配方量制备时,既能保证制得的皮肤护理组合物的具有良好的机械性能、抑菌性、耐湿性和耐水性等,又能降低其制备成本。
优选地,所述成膜剂为聚乙烯醇缩甲醛。聚乙烯醇缩甲醛作为成膜剂,与本发明皮肤护理组合物的其它成分复配后,具有良好的耐用性、吸湿性、保暖性、耐磨蚀和耐日光性。
优选地,所述增稠剂为松香、松香酯、氢化松香、马来松香、乙基纤维素和丙烯酸树脂中的至少一种。
优选地,所述增塑剂为苯二甲酸酯类增塑剂、柠檬酸酯类增塑剂、脂肪族二元酸酯类增塑剂和多元醇酯类增塑剂中的至少一种。
更优选的,所述苯二甲酸酯类增塑剂包括邻苯二甲酸辛十三酯、邻苯二甲酸丁十四酯、邻苯二甲酸仲异辛酯、邻苯二甲酸丁苄酯、邻苯二甲酸二甲氧基乙酯和丁基邻苯二甲酰基乙醇酸丁酯中的至少一种。
更优选的,所述柠檬酸酯类增塑剂包括柠檬酸三丁酯、乙酰柠檬酸三丁酯和柠檬酸三乙酯中的至少一种。
更优选的,所述脂肪族二元酸酯类增塑剂包括丁二酸酯、戊二酸酯、己二酸酯、辛二酸酯、癸二酸酯、十二烷二酸酯和十三烷二酸酯中的至少一种。
更优选的,所述多元醇酯类增塑剂包括二甘醇二苯甲酸酯、二丙二醇二苯甲酸酯、二缩三乙二醇二苯甲酸酯、2,2,4-三甲基-1,3-戊二醇-异丁酸-苯甲酸酯、甘油三苯甲酸酯和甘油单乳酸酯三苯甲酸酯中的至少一种。
本发明的成膜剂、增稠剂和增塑剂无毒性,资源充足,容易得到,使用成本低。所述成膜剂、增稠剂和增塑剂的复配使得皮肤护理组合物涂抹于皮肤上后会形成具有适宜韧性和强度的透明薄膜,所述透明薄膜便于使用者观察被覆盖皮肤的情况,便于及时治疗。所述透明薄膜还具有耐湿性、耐摩擦性及耐水性,能有效防止创面被二次损伤,还可防止创面水分散失,维持创面湿润,利于创面愈合。
优选地,所述抑菌剂为茶树精油、薄荷脑、薄荷醇、牛至油、松节油和植物多酚类化合物中的至少一种。
最优选地,所述抑菌剂在所述皮肤护理组合物中的重量百分含量为0.5%。
优选地,所述植物多酚类化合物为黄酮、异黄酮、黄酮醇、黄烷酮、黄烷醇、黄烷酮醇、查耳酮、芸香苷、橘皮苷、栎素、绿茶多酚、花色糖苷、花色苷酸、甘草素、二氢槲皮素、二氢桑色素、芹菜素、木犀素、山奈素、槲皮素、槲皮苷、葛根素、大豆苷、大豆素、紫檀素、红花苷、硫磺菊素、矢车菊素、飞燕草素、天竺葵素、儿茶素类、香豆酸、根皮素、根皮苷、茶多酚、葡多酚、白藜芦醇、绿原酸、没食子酸、苹果多酚、鞣花酸、原花色素、没食子单宁和鞣花单宁中的至少一种。
优选地,所述皮肤调节剂为维生素A、胡萝卜素、类胡萝卜素、维生素E、维生素E衍生物和酯化维生素C中的至少一种。
本发明的抑菌剂为天然植物的提取物,天然无毒,具有广谱抑菌性能。在所述皮肤护理组合物中加入所述抑菌剂和皮肤调节剂,能有效促进伤口愈合,增强皮肤的抵抗力,还可进一步防止伤口被感染恶化,防止伤口炎症及化脓。
优选地,所述溶剂为乙醇、异丙醇、丙醇和六甲基二硅醚中的至少一种。本发明的溶剂与其它组分具有良好的相溶性,使皮肤护理组合物的稳定性好。
基于所述皮肤护理组合物的上述配方,当对配方的组分之间选用不同的用量比例搭配时,可将所述皮肤护理组合物制成不同的剂型。优选地,所述皮肤护理组合物的剂型为溶液、膏体、喷雾或乳液。
优选地,所述皮肤护理组合物的制备方法,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,50~80℃下水浴加热,搅拌至分散均匀即可。
本发明的有益效果为:本发明的皮肤护理组合物的配方搭配合理,制备成本低廉,使用方便,直接涂抹于皮肤上即可形成具有适宜强度和韧性的透明薄膜,使用舒适性好,无紧绷感,方便观察被覆盖皮肤创面的情况,以便及时治疗。所述皮肤护理组合物还具有良好的耐湿性、耐摩擦性、耐水性及抑菌性,可对皮肤起到很好的保护作用,使皮肤与外界环境隔离,防止创面炎症及受感染,降低创面进一步恶化的风险,还可防止创面水分散失,维持创面湿润,利于创面愈合,且能满足在潮湿环境中短时间使用的要求。
具体实施方式
为更清楚地表述本发明的技术方案,下面结合具体实施例进一步说明,但不能用于限制本发明,此仅是本发明的部分实施例而已。
实施例1
本实施例1提供一种皮肤护理组合物,按重量百分含量计,包括:成膜剂1%、增稠剂0.5%、增塑剂0.5%、抑菌剂2%、皮肤调节剂2%及溶剂余量。
所述成膜剂为聚乙烯醇缩甲醛;所述增稠剂为松香和松香酯;所述增塑剂为苯二甲酸酯类增塑剂,具体的,所述苯二甲酸酯类增塑剂为邻苯二甲酸辛十三酯;所述抑菌剂为茶树精油和植物多酚类化合物,具体的,本实施例的植物多酚类化合物为黄酮和异黄酮;所述皮肤调节剂为维生素A和胡萝卜素;所述溶剂为乙醇。
所述皮肤护理组合物的制备方法,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,50℃下水浴加热,搅拌至分散均匀即可。
实施例2
本实施例2提供一种皮肤护理组合物,按重量百分含量计,包括:成膜剂5%、增稠剂3%、增塑剂3%、抑菌剂1%、皮肤调节剂1%及溶剂余量。
所述成膜剂为聚乙烯醇缩甲醛;所述增稠剂为氢化松香;所述增塑剂为柠檬酸酯类增塑剂,具体的,所述柠檬酸酯类增塑剂为柠檬酸三丁酯;所述抑菌剂为牛至油;所述皮肤调节剂为类胡萝卜素和维生素E;所述溶剂为异丙醇。
所述皮肤护理组合物的制备方法,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,60℃下水浴加热,搅拌至分散均匀即可。
实施例3
本实施例3提供一种皮肤护理组合物,按重量百分含量计,包括:成膜剂10%、增稠剂5%、增塑剂5%、抑菌剂0.5%、皮肤调节剂0.5%及溶剂余量。
所述成膜剂为聚乙烯醇缩甲醛;所述增稠剂为马来松香;所述增塑剂为脂肪族二元酸酯类增塑剂,具体的,所述脂肪族二元酸酯类增塑剂为十二烷二酸酯;所述抑菌剂为松节油和植物多酚类化合物,具体的,所述植物多酚类化合物为绿茶多酚、花色糖苷和根皮苷;所述皮肤调节剂为酯化维生素C和维生素E衍生物;所述溶剂为丙醇。
所述皮肤护理组合物的制备方法,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,70℃下水浴加热,搅拌至分散均匀即可。
实施例4
本实施例4提供一种皮肤护理组合物,按重量百分含量计,包括:成膜剂15%、增稠剂8%、增塑剂8%、抑菌剂0.1%、皮肤调节剂0.1%及溶剂余量。
所述成膜剂为聚乙烯醇缩甲醛;所述增稠剂为乙基纤维素;所述增塑剂为多元醇酯类增塑剂,具体的,所述多元醇酯类增塑剂为二甘醇二苯甲酸酯;所述抑菌剂为茶树精油和薄荷脑;所述皮肤调节剂为维生素A和维生素E衍生物;所述溶剂为六甲基二硅醚。
所述皮肤护理组合物的制备方法,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,75℃下水浴加热,搅拌至分散均匀即可。
实施例5
本实施例5提供一种皮肤护理组合物,按重量百分含量计,包括:成膜剂20%、增稠剂10%、增塑剂10%、抑菌剂0.01%、皮肤调节剂0.01%及溶剂余量。
所述成膜剂为聚乙烯醇缩甲醛;所述增稠剂为丙烯酸树脂;所述增塑剂为多元醇酯类增塑剂,具体的,所述多元醇酯类增塑剂为甘油单乳酸酯三苯甲酸酯;所述抑菌剂为薄荷醇和植物多酚类化合物,具体的,所述植物多酚类化合物为香豆酸和葡多酚;所述皮肤调节剂为胡萝卜素和维生素E;所述溶剂为乙醇。
所述皮肤护理组合物的制备方法,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,80℃下水浴加热,搅拌至分散均匀即可。
实验例
分别以实施例1~5的皮肤护理组合物作为样品液,进行以下试验:
一、抑菌性试验
将白色念珠菌(ATCC14053)、大肠杆菌(ATCC25922)、金黄色葡萄球菌(ATCC6538)、铜绿假单胞菌(ATCC27853)、黑曲霉(ATCC16404)、枯草芽孢杆菌(ATCC6633)分别在各自对应的固体平板上划线,细菌于37±1℃培养24h,真菌于28±1℃培养48h。然后挑取单菌落,接种于3~5mL的液体培养基中,细菌接种于胰酪大豆胨培养基,霉菌接种于马铃薯葡萄糖培养基。细菌于37±1℃,真菌于28±1℃,220r/min震荡培养过夜。按1%~2%的体积比率将培养过夜的菌液接种于适量的各自对应的液体培养基中,震荡3h,当OD600=0.6-0.8时,进行抑菌试验。
将细菌与真菌分别对应的固体培养基加热融化,当培养基温度降至45℃左右时,将对数期的各细菌和真菌按2%的接种量与对应的培养基混匀,倾倒平板,待平板凝固后放入4℃冰箱中冷却保存。然后用2.7mm直径打孔器打孔,每孔注入10μL的样品液,对照组加入无菌水。每组三个平行,倒置培养皿中,细菌37±1℃,真菌28±1℃培养过夜。根据抑菌圈大小计算抑菌率。结果如表1所示。
表1
从表1的结果可看出,本发明实施例的皮肤护理组合物都具有较好的抑菌性能。
二、安全性评价
取体重为(18±2)g的SPF级昆明小鼠,采用8%硫化钠溶液作为脱毛剂,对小鼠背部进行脱毛处理,并用温水洗去脱下的毛和脱毛剂。将样品液涂于脱毛部位,每只小鼠200μL,每天涂一次,连续涂一周并观察,评价其安全性。结果,在整个试验过程中及试验结束后,所有参加试验的小鼠皮肤均无出现任何过敏现象,说明本发明的皮肤护理组合物对皮肤温和无刺激。
三、阻菌试验
将冻存的金黄色葡萄球菌复苏,划线至平板,37℃生长48h,挑取菌落在TSB(胰蛋白胨大豆肉汤,tryptic soy broth)液体培养基中,37℃,130r/min震荡过夜培养,第2日再重新接种至新的TSB培养基中;当细菌长至对数期时,取培养液离心,6000r/min,15min,用无菌PBS快速洗涤2次,然后悬浮细菌至109CFU/mL。同时将对数期的细菌培养液以无菌PBS缓冲液梯度稀释,涂板统计菌落个数,计算实际感染菌量。
将8周龄,体重(18±2)g的SPF级昆明小鼠适应饲养三天后,随机分成六组,5个实验组和1个对照组,各6只。实验前每只小鼠注射0.1mL的1.0%戊巴比妥钠,待其完全麻醉后,用蜜蜡脱毛膏将小鼠背部脊柱中间被毛除去作为实验部位,酒精消毒后,在皮肤上剪开3cm长的伤口,再缝合,酒精消毒后,实验组的缝合处分别涂抹样品液0.1mL,待其凝固形成薄膜后,再涂抹金黄色葡萄球菌0.1mL;对照组在缝合处直接涂抹金黄色葡萄球菌。每天观察小鼠受损区皮肤的红肿、炎症等情况,连续观察14天。结果如表2所示:
表2
从表2的观察结果可见,本发明的皮肤护理组合物可有效阻隔细菌感染伤口,能防止伤口炎症及恶化,利于伤口愈合。
四、水蒸汽透过试验
量取15mL的样品液,将其流延平铺于7cm*11.5cm透明玻璃板上,置于50℃烘箱内干燥30min,取出,从玻璃板上揭下膜,称取0.5g膜,将其覆盖在开口瓶的瓶口处(面积为1.77cm2),其中小瓶中含有10g无水CaCl2,用聚四氟乙烯带将瓶口四周密封;阳性对照组采用密封的小瓶,小瓶中含有10g无水CaCl2;阴性对照组采用开口的小瓶,小瓶中含有10g无水CaCl2;每组各做三个平行。将所有小瓶置于干燥器内,其中干燥器内含有饱和NaCl溶液(其相对湿度为70%RH),将干燥器置于37℃烘箱内,在一定的时间间隔测定小瓶的质量,计算水蒸汽透过率,结果如表3所示。
表3
试验组 | 水蒸汽透过率(g/m2*24h) |
阳性对照组 | 30±2.56 |
实施例1 | 532±1.35 |
实施例2 | 548±5.62 |
实施例3 | 568±2.36 |
实施例4 | 579±2.58 |
实施例5 | 603±3.58 |
阴性对照组 | 8635±3.12 |
从表3的结果可见,与阴性对照组相比,本发明的皮肤护理组合物可以有效地减少水蒸汽透过率,由此说明,本发明的皮肤护理组合物所形成的膜可以防止水分散失,维持创面湿润。
五、耐摩擦性试验
在室温(20℃)下,分别将实施例1~5的皮肤护理组合物涂抹于透明玻璃板上,使其成膜,然后分别用干燥医用纱布和湿润医用纱布做机械控制往复摩擦,记录造成孔洞的摩擦次数。试验结果显示,实施例1~5的皮肤护理组合物得到的单层膜的干摩擦次数均大于1000次,湿摩擦次数均大于50次,分别重复三次,试验结果均相同,说明本发明的皮肤护理组合物具有很好的耐摩擦性且能满足在潮湿环境中短时间使用的要求。
六、抗拉伸性试验
在室温(20℃)下,分别将实施例1~5的皮肤护理组合物涂抹于透明玻璃板上,使其成膜,然后将膜取下,用一个夹具夹持膜的自由端,另一端用拉力机测试膜的断裂强度和断裂伸长率,试验结果显示,实施例1~5的皮肤护理组合物得到的单层膜的断裂强度均大于5N,断裂伸长率均大于50%,试验重复三次,结果均相同。说明本发明的皮肤护理组合物具有一定的强度和延展性,涂于皮肤上易形成完整膜,无紧绷感。
最后应当说明的是,以上实施例仅用以说明本发明的技术方案而非对其限制。尽管参照上述实施例对本发明进行了详细的说明,所属领域的普通技术人员应当理解:依然可以对本发明的具体实施方式进行修改或者等同替换,而未脱离本发明精神和范围的任何修改或者等同替换,其均应涵盖在本发明的权利要求范围当中。
Claims (10)
1.一种皮肤护理组合物,其特征在于,按重量百分含量计,包括:成膜剂1%~20%、增稠剂0.5%~10%、增塑剂0.5%~10%、抑菌剂0.01%~2%、皮肤调节剂0.01%~2%及溶剂余量。
2.如权利要求1所述的皮肤护理组合物,其特征在于,所述成膜剂为聚乙烯醇缩甲醛。
3.如权利要求1所述的皮肤护理组合物,其特征在于,所述增稠剂为松香、松香酯、氢化松香、马来松香、乙基纤维素和丙烯酸树脂中的至少一种。
4.如权利要求1所述的皮肤护理组合物,其特征在于,所述增塑剂为苯二甲酸酯类增塑剂、柠檬酸酯类增塑剂、脂肪族二元酸酯类增塑剂和多元醇酯类增塑剂中的至少一种。
5.如权利要求1所述的皮肤护理组合物,其特征在于,所述抑菌剂为茶树精油、薄荷脑、薄荷醇、牛至油、松节油和植物多酚类化合物中的至少一种。
6.如权利要求5所述的皮肤护理组合物,其特征在于,所述植物多酚类化合物为黄酮、异黄酮、黄酮醇、黄烷酮、黄烷醇、黄烷酮醇、查耳酮、芸香苷、橘皮苷、栎素、绿茶多酚、花色糖苷、花色苷酸、甘草素、二氢槲皮素、二氢桑色素、芹菜素、木犀素、山奈素、槲皮素、槲皮苷、葛根素、大豆苷、大豆素、紫檀素、红花苷、硫磺菊素、矢车菊素、飞燕草素、天竺葵素、儿茶素类、香豆酸、根皮素、根皮苷、茶多酚、葡多酚、白藜芦醇、绿原酸、没食子酸、苹果多酚、鞣花酸、原花色素、没食子单宁和鞣花单宁中的至少一种。
7.如权利要求1所述的皮肤护理组合物,其特征在于,所述皮肤调节剂为维生素A、胡萝卜素、类胡萝卜素、维生素E、维生素E衍生物和酯化维生素C中的至少一种。
8.如权利要求1所述的皮肤护理组合物,其特征在于,所述溶剂为乙醇、异丙醇、丙醇和六甲基二硅醚中的至少一种。
9.如权利要求1~8任一项所述的皮肤护理组合物,其特征在于,所述皮肤护理组合物的剂型为溶液、膏体、喷雾或乳液。
10.如权利要求1~9任一项所述的皮肤护理组合物的制备方法,其特征在于,包括如下步骤:将成膜剂、增稠剂、增塑剂、抑菌剂和皮肤调节剂依次加入溶剂中,50~80℃下水浴加热,搅拌至分散均匀即可。
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CN108578279A (zh) * | 2018-06-29 | 2018-09-28 | 广州昕生医学材料有限公司 | 一种皮肤护理组合物的应用 |
WO2021243669A1 (en) * | 2020-06-05 | 2021-12-09 | Henkel Ag & Co. Kgaa | Use of a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups as a microbiome regulator on scalp |
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