CN108867048A - 一种可快速止血手术纱布的制备方法及其应用 - Google Patents
一种可快速止血手术纱布的制备方法及其应用 Download PDFInfo
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Abstract
本发明公开了一种可快速止血手术纱布的制备方法及其应用,该方法采用将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水配制成混合纺丝液,随后离心、静置、去除沉淀,接着进行真空脱泡,随后加入湿法纺丝机中通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,再经过拉伸、定型、纺织处理得到坯布,再将得到的坯布浸入退煮漂联合机的热水槽中进行高温清洗和改性,最后将改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水组成的混合液中进行二次改性,并经开幅、烘干得到成品纱布。制备而成的手术纱布,其止血性能好,在医疗用品行业中具有良好的应用前景。
Description
技术领域
本发明涉及医用敷料技术领域,具体涉及一种可快速止血手术纱布的制备方法及其应用。
背景技术
止血是外科基本操作技术的核心之一,人体任何部位的外科操作几乎无一例外地涉及到出血与止血,止血技术已由过去单纯的器械止血措施发展为现代外科条件下的纷繁复杂的技术体系。其中止血材料的应用成为这个过程中重要的一部分。传统棉制品材料:传统棉制品材料如简单的脱脂棉、纱布等,价格低廉,使用方便,但只对创面起物理保护作用,没有凝血因子,且容易粘连创面。纱布是常见的医疗用品,传统的止血纱布存在止血慢、易粘连伤口、不损伤创面等问题,为了保证患者的生命安全,需要开发止血效果快速,能够保护创面、促进伤口愈合的新型止血纱布。将纱布上涂抹含有中草药的止血纱布胶状凝胶,无疑是一种理想的产品,利用中草药的活性成分,实现消毒杀菌、止血止痛、促进伤口愈合等功能,较之于传统纱布生产工艺简单、药性温和无刺激、对人体危害小,患者接受度高,市场应用价值巨大。
发明内容
为解决上述技术问题,本发明提供一种可快速止血手术纱布的制备方法及其应用,该方法采用将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水配制成混合纺丝液,随后离心、静置、去除沉淀,接着进行真空脱泡,随后加入湿法纺丝机中通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,再经过拉伸、定型、纺织处理得到坯布,再将得到的坯布浸入退煮漂联合机的热水槽中进行高温清洗和改性,最后将改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水组成的混合液中进行二次改性,并经开幅、烘干得到成品纱布。制备而成的手术纱布,其止血性能好,在医疗用品行业中具有良好的应用前景。
本发明的目的可以通过以下技术方案实现:
一种可快速止血手术纱布的制备方法,包括以下步骤:
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为6-8倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用85-90℃的水清洗45-55分钟,再将水温升至95-100℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,清洗15-20分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水组成的混合液中,用稀盐酸调整混合液的pH为3.5-4.5,浸泡3-5小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在115-135℃下烘干处理35-45分钟,即得成品手术纱布。
进一步的,所述步骤(1)中超声分散的频率为20-25kHz,超声功率为200-300W,超声处理时间为30-40分钟。
进一步的,所述步骤(2)中真空脱泡的真空度为-0.08至-0.1MPa,脱泡时间为40-60分钟。
进一步的,所述步骤(2)中的凝固浴温度为50℃,纺丝温度为85-95℃,喷丝孔直径为0.5mm。
进一步的,所述步骤(3)中的改性剂在水中的浓度为3-4g/L。
进一步的,所述步骤(4)中三乙醇胺、甘油松香树脂、壳聚糖与水的质量比为2:3:6:150
进一步的,本发明还公开了所述制备方法制得的可快速止血手术纱布在医疗用品行业中的应用。
本发明与现有技术相比,其有益效果为:
(1)本发明的手术纱布的制备方法采用将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水配制成混合纺丝液,随后离心、静置、去除沉淀,接着进行真空脱泡,随后加入湿法纺丝机中通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,再经过拉伸、定型、纺织处理得到坯布,再将得到的坯布浸入退煮漂联合机的热水槽中进行高温清洗和改性,最后将改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水组成的混合液中进行二次改性,并经开幅、烘干得到成品纱布。制备而成的手术纱布,其止血性能好,在医疗用品行业中具有良好的应用前景。
(2)本发明采用了聚丙烯酸钠、粘胶纤维素、三乙醇胺、甘油松香树脂这几种原料参与制备手术纱布,对手术纱布进行了有效的性能提升,虽然这些材料并非首次应用于手术纱布中,但按照一定配比量组合并辅以相应的处理方式,给最后制备得到的手术纱布带来了使用性能上的大幅度提高,这在以往的研究中是不曾报道过的,对于实现本发明的技术效果起到了决定性的作用。
具体实施方式
下面结合具体实施例对发明的技术方案进行详细说明。
实施例1
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为20kHz,超声功率为200W,超声处理时间为30分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.08MPa,脱泡时间为40分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为85℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为6倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用85℃的水清洗45分钟,再将水温升至95℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为3g/L,清洗15分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水按照质量比为2:3:6:150组成的混合液中,用稀盐酸调整混合液的pH为3.5,浸泡3小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在115℃下烘干处理35分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
实施例2
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为22.5kHz,超声功率为250W,超声处理时间为35分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.09MPa,脱泡时间为50分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为90℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为7倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用87.5℃的水清洗50分钟,再将水温升至97.5℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为3.5g/L,清洗17.5分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水按照质量比为2:3:6:150组成的混合液中,用稀盐酸调整混合液的pH为4,浸泡4小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在125℃下烘干处理40分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
实施例3
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为25kHz,超声功率为300W,超声处理时间为40分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.1MPa,脱泡时间为60分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为95℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为8倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用90℃的水清洗55分钟,再将水温升至100℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为4g/L,清洗20分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水按照质量比为2:3:6:150组成的混合液中,用稀盐酸调整混合液的pH为4.5,浸泡5小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在135℃下烘干处理45分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
对比例1
(1)将粘胶纤维素、羟乙基纤维素粉末和去离子水按照1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为22.5kHz,超声功率为250W,超声处理时间为35分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.09MPa,脱泡时间为50分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为90℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为7倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用87.5℃的水清洗50分钟,再将水温升至97.5℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为3.5g/L,清洗17.5分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水按照质量比为2:3:6:150组成的混合液中,用稀盐酸调整混合液的pH为4,浸泡4小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在125℃下烘干处理40分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
对比例2
(1)将聚丙烯酸钠、羟乙基纤维素粉末和去离子水按照2:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为22.5kHz,超声功率为250W,超声处理时间为35分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.09MPa,脱泡时间为50分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为90℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为7倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用87.5℃的水清洗50分钟,再将水温升至97.5℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为3.5g/L,清洗17.5分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水按照质量比为2:3:6:150组成的混合液中,用稀盐酸调整混合液的pH为4,浸泡4小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在125℃下烘干处理40分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
对比例3
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为22.5kHz,超声功率为250W,超声处理时间为35分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.09MPa,脱泡时间为50分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为90℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为7倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用87.5℃的水清洗50分钟,再将水温升至97.5℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为3.5g/L,清洗17.5分钟;
(4)将得到的改性坯布浸泡于由甘油松香树脂、壳聚糖、水按照质量比为3:6:150组成的混合液中,用稀盐酸调整混合液的pH为4,浸泡4小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在125℃下烘干处理40分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
对比例4
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,超声分散的频率为22.5kHz,超声功率为250W,超声处理时间为35分钟,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,真空脱泡的真空度为-0.09MPa,脱泡时间为50分钟,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,凝固浴温度为50℃,纺丝温度为90℃,喷丝孔直径为0.5mm,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为7倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用87.5℃的水清洗50分钟,再将水温升至97.5℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,改性剂在水中的浓度为3.5g/L,清洗17.5分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、壳聚糖、水按照质量比为2:6:150组成的混合液中,用稀盐酸调整混合液的pH为4,浸泡4小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在125℃下烘干处理40分钟,即得成品手术纱布。
制得的手术纱布的性能测试结果如表1所示。
将实施例1-3和对比例1-4的制得的手术纱布分别按照国家或行业标准中的测试方法进行吸湿率、断裂率、下沉时间、细胞毒性试验这几项性能测试。
表1
本发明的手术纱布的制备方法采用将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水配制成混合纺丝液,随后离心、静置、去除沉淀,接着进行真空脱泡,随后加入湿法纺丝机中通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,再经过拉伸、定型、纺织处理得到坯布,再将得到的坯布浸入退煮漂联合机的热水槽中进行高温清洗和改性,最后将改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水组成的混合液中进行二次改性,并经开幅、烘干得到成品纱布。制备而成的手术纱布,其止血性能好,在医疗用品行业中具有良好的应用前景。并且,本发明采用了聚丙烯酸钠、粘胶纤维素、三乙醇胺、甘油松香树脂这几种原料参与制备手术纱布,对手术纱布进行了有效的性能提升,虽然这些材料并非首次应用于手术纱布中,但按照一定配比量组合并辅以相应的处理方式,给最后制备得到的手术纱布带来了使用性能上的大幅度提高,这在以往的研究中是不曾报道过的,对于实现本发明的技术效果起到了决定性的作用。
以上所述仅为本发明的实施例,并非因此限制本发明的专利范围,凡是利用本发明说明书内容所作的等效结构或等效流程变换,或直接或间接运用在其他相关的技术领域,均同理包括在本发明的专利保护范围内。
Claims (7)
1.一种可快速止血手术纱布的制备方法,其特征在于,包括以下步骤:
(1)将聚丙烯酸钠、粘胶纤维素、羟乙基纤维素粉末和去离子水按照2:1:5:23的质量比进行混合,经超声分散处理后经充分搅拌形成混合纺丝液,随后将混合纺丝液离心后静置过夜,过滤除去混合纺丝液中的沉淀物,备用;
(2)将纺丝液进行真空脱泡,随后加入湿法纺丝机中,通过计量泵计量、喷丝头压出后在凝固浴中析出并形成纤维细丝,所述凝固浴为二甲基乙酰胺、硫酸钠的混合醇溶液,其中二甲基乙酰胺、硫酸钠、乙醇的摩尔比为3:10:55,再经过拉伸、定型、纺织处理得到坯布,拉伸倍数为6-8倍;
(3)将得到的坯布浸入退煮漂联合机的热水槽中,设定浴比为1:20,先用85-90℃的水清洗45-55分钟,再将水温升至95-100℃,加入改性剂,改性剂为1-胺丙基-4-甲基咪唑四氟硼酸盐、海藻酸丙二酯、丙三醇二缩水甘油醚、三嗪双季铵盐按照1:1:2:5的质量比所组成的混合物,清洗15-20分钟;
(4)将得到的改性坯布浸泡于由三乙醇胺、甘油松香树脂、壳聚糖、水组成的混合液中,用稀盐酸调整混合液的pH为3.5-4.5,浸泡3-5小时,随后将浸泡后的改性坯布用清水洗涤至表面为中性,经脱水得到二次改性坯布;
(5)将得到的二次改性坯布经开幅机开幅,然后经烘干机在115-135℃下烘干处理35-45分钟,即得成品手术纱布。
2.根据权利要求1所述的可快速止血手术纱布的制备方法,其特征在于,所述步骤(1)中超声分散的频率为20-25kHz,超声功率为200-300W,超声处理时间为30-40分钟。
3.根据权利要求1所述的可快速止血手术纱布的制备方法,其特征在于,所述步骤(2)中真空脱泡的真空度为-0.08至-0.1MPa,脱泡时间为40-60分钟。
4.根据权利要求1所述的可快速止血手术纱布的制备方法,其特征在于,所述步骤(2)中的凝固浴温度为50℃,纺丝温度为85-95℃,喷丝孔直径为0.5mm。
5.根据权利要求1所述的可快速止血手术纱布的制备方法,其特征在于,所述步骤(3)中的改性剂在水中的浓度为3-4g/L。
6.根据权利要求1所述的可快速止血手术纱布的制备方法,其特征在于,所述步骤(4)中三乙醇胺、甘油松香树脂、壳聚糖与水的质量比为2:3:6:150。
7.根据权利要求1-6任一项所述制备方法制得的可快速止血手术纱布在医疗用品行业中的应用。
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