CN108863766A - A method of lactic acid is extracted using the solvent way of distillation - Google Patents
A method of lactic acid is extracted using the solvent way of distillation Download PDFInfo
- Publication number
- CN108863766A CN108863766A CN201810745613.6A CN201810745613A CN108863766A CN 108863766 A CN108863766 A CN 108863766A CN 201810745613 A CN201810745613 A CN 201810745613A CN 108863766 A CN108863766 A CN 108863766A
- Authority
- CN
- China
- Prior art keywords
- lactic acid
- organic solvent
- solvent
- variety
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
- C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention belongs to chemical fields, propose a kind of method for extracting lactic acid using the solvent way of distillation, include the following steps：1) crude product solution containing lactic acid is sufficiently mixed with organic solvent, make lactic acid molecules be effectively transferred to organic solvent by the method for distillation or lactic acid is made, simultaneously from distilling in mixture or distilling lactic acid individually from organic solvent, to obtain the lactic acid of the organic phase containing lactic acid or purifying with organic solvent；2) it directly acquires lactic acid obtained in step 1) or is further purified to obtain the lactic acid of high-purity or mixes the organic solvent containing lactic acid with water, obtain lactic acid aqueous solution, it further obtains the lactic acid of high-purity or mixes the organic solvent containing lactic acid with alkaline solution, lactate solution is obtained, the lactate of high-purity is further obtained.More pure lactic acid, lactate and/or other lactic products can be made by a variety of traditional methods known to industry technical staff into the lactic acid in organic phase.
Description
Technical field
The present invention relates to chemical fields, specifically, relating to the use of the method that the solvent way of distillation extracts lactic acid.
Background technique
Lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) is also known as Lactic acid mainly using starch biomass as raw material
It is produced through microbial fermentation or using chemical synthesis, it is all multiple to be widely used in food, medicine, chemical industry, new material, feed etc.
Want industrial field.Existing lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) production technology is mostly that fermentation method produces, lactic acid (D-ALPHA-Hydroxypropionic acid,
Pfansteihl, DL-LACTIC ACID) extractive technique mainly has solvent extraction technology, molecular distillation technique, membrane separation technique, chromatographic isolation skill
Art etc..
As the industries such as food, medicine, chemical industry, new material are to the product of lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) product
Matter requires higher and higher, the especially application and development of polylactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) material, to monomer original
More stringent requirements are proposed for the quality of material lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID).
More economical and effective high-pure lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) is prepared method proposes a kind of
Method.
Summary of the invention
The invention proposes a kind of to extract the side of lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) using the solvent way of distillation
Method.The solvent way of distillation be exactly distilled using solvent be dehydrated or (and) de- volatile material to be to reach point of target product
From, purifying and extract purpose.Volatile material includes inorganic matter, organic matter, can also be solvent itself.
Technical scheme is as follows：
A method of lactic acid being extracted using the solvent way of distillation, the lactic acid is D-ALPHA-Hydroxypropionic acid, in Pfansteihl, DL-LACTIC ACID
It is one or more；It includes the following steps：
1) crude product solution containing lactic acid is sufficiently mixed with organic solvent, by the method for distillation lactic acid molecules is had
It is transferred to organic solvent or distills lactic acid from mixture simultaneously with organic solvent or make lactic acid individually from organic to effect
It is distilled in solvent, obtains lactic acid (the D- cream of the organic phase containing lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) or purifying
Acid, Pfansteihl, DL-LACTIC ACID)；
2) it directly acquires lactic acid obtained in step 1) or is further purified to obtain the lactic acid of high-purity or lactic acid will be contained
Organic solvent mixed with water, obtain lactic acid aqueous solution, further obtain high-purity lactic acid or will be organic molten containing lactic acid
Agent is mixed with alkaline solution, obtains lactate solution, further obtains the lactate of high-purity.
Wherein, the crude product solution containing lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) includes one in following solution
Kind is a variety of：(1) lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) fermentation liquid being directly prepared by fermentation；(2) containing cream
Lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) fermentation liquid of sour (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) salt, passes through acidolysis lactic acid
Raw lactic acid (D-ALPHA-Hydroxypropionic acid, the Pfansteihl, DL-LACTIC ACID) solution obtained after (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) salt；(3) pass through
The solution containing lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) that other approach obtain.
Wherein, the organic solvent is selected from the mixture of a kind of following organic compound or a variety of organic compounds：
Esters, ketone, ethers, alcohols, phosphoric acid ester, phosphorus oxygen class, sulphur oxygen class, phosphine sulphur class, amine, amides, alkanes
And other organic compounds；The boiling point of the organic compound is all larger than 100 DEG C under normal pressure.
Preferably, the esters include one of amyl acetate, tributyl citrate or a variety of；Ketone includes 2- heptan
Ketone；Ethers includes butyl ether；Alcohols includes one of the higher alcohols of octanol, certain herbaceous plants with big flowers alcohol, laruyl alcohol, carbon atom number from 14 to 24 or more
The mixture of kind；Phosphoric acid ester includes one of tributyl phosphate, P507, P204 or a variety of；Phosphorus oxygen class includes trioctylphosphine oxygen
Phosphine；Sulphur oxygen class includes one of dimethyl sulfone, dimethyl sulfoxide or a variety of；Phosphine sulphur class includes triisobutyl phosphine sulfide；Amine
Including one of trioctylamine, three certain herbaceous plants with big flowers amine, Alamine 304, three pungent certain herbaceous plants with big flowers alkyl tertiary amines or a variety of mixtures；Amides include
N.N- dibutyl formamide；Alkanes include one of the alkane of octane, certain herbaceous plants with big flowers alkane, carbon atom number from 12 to 24 or a variety of mixed
Close object.
Wherein, the mixing ratio of the crude product solution containing lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) and organic solvent
Example is 1:100~100:1.
Wherein, the condition of the solvent distillation is vacuum distillation, and vapo(u)rizing temperature is 0 DEG C~250 DEG C.
Wherein, the step 2) is specially：The organic solvent and water of lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) will be contained
Mixing, lactic acid (D-ALPHA-Hydroxypropionic acid, the Pfansteihl, DL-LACTIC ACID) aqueous solution purified；Or will containing lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl,
DL-LACTIC ACID) organic solvent mixed with alkaline solution, obtain lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) salting liquid.
Organic solvent after separating lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) can return in step 1) and be recycled.
The present invention relates to operation be unless otherwise specified this field routine operation, related distillation equipment can be
Known Conventional vaporizer (such as single effect evaporator or multi-effect evaporator or MVR evaporator etc.) or highly efficient in industry
Evaporator (such as scraper evaporator, short-path evaporator, molecular distillation equipment etc.).Distillation equipment referred to above can be independent
Use, can also multiple combinations carry out using.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can be combined with each other, obtain specific embodiment party
Formula.
The beneficial effects of the present invention are：
The solvent way of distillation of the present invention extracts lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID), short with process route,
Easy to operate, the features such as product purity is high, extract yield is high, environmental pollution is small, avoid traditional lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl,
DL-LACTIC ACID) operating process complicated in production technology.It can into the lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) in organic phase
By a variety of traditional methods known to industry technical staff be made more pure lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl,
DL-LACTIC ACID), lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) salt and/or other lactic acid (D-ALPHA-Hydroxypropionic acid, Pfansteihl, DL-LACTIC ACID) produce
Product.
Specific embodiment
The preferred embodiment of the present invention is described in detail below in conjunction with embodiment.It will be appreciated that following real
Providing merely to play the purpose of explanation for example is applied, is not used to limit the scope of the present invention.The skill of this field
Without departing from the spirit and purpose of the present invention, the various modifications and replacement carry out to the present invention are accordingly to be regarded as this to art personnel
The technology scope of invention.
Embodiment 1
Taking concentration is 50% crude product Pfansteihl solution 100g, organic solvent 455g (wherein three pungent ammonium 182g, eight charcoal alcohol
45g, kerosene 228g) it is put in three-necked flask；
Above-mentioned mixed liquor is concentrated in vacuo in 80 DEG C, is concentrated into that there is no condensed waters to go out, obtains containing Pfansteihl
Organic solvent.Organic solvent containing Pfansteihl is transferred in another three-necked flask.Add water with it is organic molten containing Pfansteihl
Agent is in 90 DEG C of mixing then by the isolated solution containing Pfansteihl of organic solvent.
It is computed, the yield of Pfansteihl is 92.5%；
Through detecting, the purity of isolated Pfansteihl is 99%.
Although above having used general explanation, specific embodiment and example, the present invention is made to retouch in detail
It states, but on the basis of the present invention, certain supplement and optimization can be made to the discrimination model of this method.Therefore, without departing from
These modifications or improvements on the basis of spirit of that invention, fall within the scope of the claimed invention.
Claims (7)
1. a kind of method for extracting lactic acid using the solvent way of distillation, the lactic acid is D-ALPHA-Hydroxypropionic acid, Pfansteihl, one in DL-LACTIC ACID
Kind is a variety of；It is characterised in that it includes following steps：
1) crude product solution containing lactic acid is sufficiently mixed with organic solvent, lactic acid molecules is made effectively by the method for distillation
It is transferred to organic solvent or lactic acid and organic solvent is made to distill from mixture simultaneously or make lactic acid individually from organic solvent
In distill, obtain the lactic acid of the organic phase containing lactic acid or purifying；
2) it directly acquires lactic acid obtained in step 1) or be further purified and obtains the lactic acid of high-purity or by having containing lactic acid
Solvent is mixed with water, obtains lactic acid aqueous solution, further obtain high-purity lactic acid or by the organic solvent containing lactic acid with
Alkaline solution mixing, obtains lactate solution, further obtains the lactate of high-purity.
2. the method according to claim 1, wherein the crude product solution containing lactic acid includes in following solution
It is one or more：(1) lactic fermentation liquid being directly prepared by fermentation；(2) containing the lactic fermentation liquid of lactate, lead to
Cross the raw lactic acid solution obtained after acidolysis lactate；(3) solution containing lactic acid obtained by other approach.
3. the method according to claim 1, wherein the organic solvent be selected from a kind of following organic compound or
The mixture of a variety of organic compounds：
Esters, ketone, ethers, alcohols, phosphoric acid ester, phosphorus oxygen class, sulphur oxygen class, phosphine sulphur class, amine, amides, alkanes and its
His organic compound；The boiling point of the organic compound is all larger than 100 DEG C under normal pressure.
4. according to the method described in claim 3, it is characterized in that, the esters include amyl acetate, in tributyl citrate
It is one or more；Ketone includes 2-HEPTANONE；Ethers includes butyl ether；Alcohols include octanol, certain herbaceous plants with big flowers alcohol, laruyl alcohol, carbon atom number from
One of 14 to 24 higher alcohols or a variety of mixtures；Phosphoric acid ester includes one of tributyl phosphate, P507, P204
Or it is a variety of；Phosphorus oxygen class includes trioctylphosphine oxide (TOPO)；Sulphur oxygen class includes one of dimethyl sulfone, dimethyl sulfoxide or a variety of；Phosphine sulphur
Class includes triisobutyl phosphine sulfide；Amine include one of trioctylamine, three certain herbaceous plants with big flowers amine, Alamine 304, three pungent certain herbaceous plants with big flowers alkyl tertiary amines or
A variety of mixtures；Amides include N.N- dibutyl formamide；Alkanes include octane, certain herbaceous plants with big flowers alkane, carbon atom number from 12 to 24
One of alkane or a variety of mixtures.
5. method according to any one of claims 1 to 4, which is characterized in that the crude product solution containing lactic acid with have
The mixed proportion of solvent is 1:100~100:1.
6. method according to any one of claims 1 to 4, which is characterized in that the condition of the solvent distillation is that decompression is steamed
It evaporates, vapo(u)rizing temperature is 0 DEG C~250 DEG C.
7. method according to any one of claims 1 to 4, which is characterized in that the step 2) is specially：Lactic acid will be contained
Organic solvent mixed with water, the lactic acid aqueous solution purified；Or mix the organic solvent containing lactic acid with alkaline solution,
Obtain lactate solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810745613.6A CN108863766A (en) | 2018-07-09 | 2018-07-09 | A method of lactic acid is extracted using the solvent way of distillation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810745613.6A CN108863766A (en) | 2018-07-09 | 2018-07-09 | A method of lactic acid is extracted using the solvent way of distillation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108863766A true CN108863766A (en) | 2018-11-23 |
Family
ID=64300222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810745613.6A Pending CN108863766A (en) | 2018-07-09 | 2018-07-09 | A method of lactic acid is extracted using the solvent way of distillation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108863766A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114591164A (en) * | 2022-01-29 | 2022-06-07 | 安徽丰原发酵技术工程研究有限公司 | Lactic acid purification method |
| CN115991646A (en) * | 2021-10-18 | 2023-04-21 | 上海凯赛生物技术股份有限公司 | Method for separating and extracting lactic acid, lactic acid product and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281778A (en) * | 2017-06-09 | 2017-10-24 | 安徽丰原发酵技术工程研究有限公司 | A kind of extraction separating method of organic acid |
| CN107324989A (en) * | 2017-06-09 | 2017-11-07 | 安徽丰原发酵技术工程研究有限公司 | It is a kind of by being dehydrated the method that extraction prepares lactic acid and lactide |
-
2018
- 2018-07-09 CN CN201810745613.6A patent/CN108863766A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281778A (en) * | 2017-06-09 | 2017-10-24 | 安徽丰原发酵技术工程研究有限公司 | A kind of extraction separating method of organic acid |
| CN107324989A (en) * | 2017-06-09 | 2017-11-07 | 安徽丰原发酵技术工程研究有限公司 | It is a kind of by being dehydrated the method that extraction prepares lactic acid and lactide |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115991646A (en) * | 2021-10-18 | 2023-04-21 | 上海凯赛生物技术股份有限公司 | Method for separating and extracting lactic acid, lactic acid product and preparation method thereof |
| CN114591164A (en) * | 2022-01-29 | 2022-06-07 | 安徽丰原发酵技术工程研究有限公司 | Lactic acid purification method |
| CN114591164B (en) * | 2022-01-29 | 2023-11-24 | 安徽丰原发酵技术工程研究有限公司 | Purification method of lactic acid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107353197A (en) | A kind of method for extracting 3 hydracrylic acids | |
| CN101925567B (en) | Method for purifying alcohol from fermentation broth | |
| US10941100B2 (en) | Method for the purification of natural vanillin | |
| CN107324989A (en) | It is a kind of by being dehydrated the method that extraction prepares lactic acid and lactide | |
| CN107281778B (en) | Extraction separation method of organic acid | |
| CN108863766A (en) | A method of lactic acid is extracted using the solvent way of distillation | |
| WO2010094630A1 (en) | Reactive extraction of free organic acids from ammonium salts thereof | |
| CN103987432A (en) | A method and an arrangement for separating at least one carboxylic acid and furfural from a dilute aqueous mixture thereof | |
| AU691294B2 (en) | Recovery of carboxylic acid from organic solution that contains an amine and an extraction enhancer | |
| CN114573421B (en) | Method for extracting and purifying sclareol from sclareol fermentation liquor | |
| CN105164101A (en) | Method for purifying 1,5-diaminopentane | |
| CN107176907A (en) | A kind of method for extracting malic acid/malate | |
| CN102964240A (en) | Preparation method of high-purity glycolic acid crystals | |
| CN107344911A (en) | A kind of method for extracting citric acid/citrate | |
| CN107849590A (en) | Pass through the production for the improved vanillic aldehyde that ferments | |
| CN106518618A (en) | Method for continuously extracting, rectificating and separating isopropanol-isopropyl ether azeotrope by mixed solvent | |
| CN108752193A (en) | A method of extracting citric acid or citrate using the solvent way of distillation | |
| CN108929218A (en) | A method of organic acid is extracted using the solvent way of distillation | |
| CN108727182A (en) | A method of extracting pyruvic acid using the solvent way of distillation | |
| CN106008160A (en) | Glycine discharging mother solution treating technology | |
| CN108675926A (en) | A method of extracting 3- hydracrylic acids using the solvent way of distillation | |
| CN108623450A (en) | A method of extracting malic acid or malate using the solvent way of distillation | |
| CN108675927A (en) | A method of extracting succinic acid or succinate using the solvent way of distillation | |
| CN104829426A (en) | Continuous isopropyl ether-isopropyl alcohol azeotrope extraction and rectification technology based on choline chloride/urea low-co-melting solvent | |
| TW553930B (en) | Method for recovering and producing C4-C6 dicarboxylate from alkaline waste solution generated in caprolactam preparation process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181123 |