CN108853719A - A kind of high voltage narrow pulse treatment system - Google Patents
A kind of high voltage narrow pulse treatment system Download PDFInfo
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- CN108853719A CN108853719A CN201810382380.8A CN201810382380A CN108853719A CN 108853719 A CN108853719 A CN 108853719A CN 201810382380 A CN201810382380 A CN 201810382380A CN 108853719 A CN108853719 A CN 108853719A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
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Abstract
The invention discloses a kind of high voltage narrow pulse treatment systems; including the output matrix module being connect with electrode unit and power supply; output matrix module is connected with transformer T1; transformer T1 is separately connected discharge prevention module and current transformer T2; discharge prevention module and current transformer T2 are connect with discharge switch S1; discharge switch S1 is connected separately with charging module and single-chip microcontroller; single-chip microcontroller is connect with charging module; R wave detection module and PC machine is also respectively connected in single-chip microcontroller, and discharge capacity C1 is provided between charging module and transformer T1.Beneficial effects of the present invention：By being used cooperatively for discharge prevention module and capacitor, can achieve the effect that protect circuit when exporting out of control and power down；By the use of output transformer and current transformer, discharge electrode and interlock circuit and other circuits can not only be made to realize and be electrically isolated, additionally it is possible to improve the working condition and EMC performance of element；Simultaneously the present invention also with high security, the advantages of good stability.
Description
Technical field
The present invention relates to the field of medical instrument technology, it particularly relates to a kind of high voltage narrow pulse treatment system.
Background technique
IRE technology full name is irreversible electroporation technology (irreversibleelectroporation, IRE), principle
It is the high voltage burst pulse electric field for applying KV level to cell, double-layer of lipoid cell membrane will appear many micropores and of short duration infiltration
Property increase, this bioelectromagnetics phenomenon is known as electroporation (electroporation).If thin after the revocation of applying pulse electric field
After birth cannot be restored to normal physiological condition, i.e., referred to as IRE (also known as irreversible electrical breakdown).This irreversible electricity of nanoscale is worn
Hole can lead to the apoptosis of cell.After apoptosis of tumor cells, internal phagocyte falls cell fragment phagocytosis, and treatment region is gradually
Replaced normal tissue.
Summary of the invention
For above-mentioned technical problem in the related technology, the present invention proposes a kind of high voltage narrow pulse treatment system, Neng Gouke
Take the above-mentioned deficiency of the prior art.
To realize the above-mentioned technical purpose, the technical proposal of the invention is realized in this way：
A kind of high voltage narrow pulse treatment system, including the output matrix module being connect with electrode unit and power supply, the output square
Array module is connected with transformer T1, and the transformer T1 is separately connected discharge prevention module and current transformer T2, the electric discharge
Protective module and current transformer T2 are connect with discharge switch S1, and the discharge switch S1 is connected separately with charge and discharge capacitance
C1, charging module（7）And single-chip microcontroller, the charging module is in parallel with discharge capacity C1, and the single-chip microcontroller and charging module connect
It connects, R wave detection module and PC machine is also respectively connected in the single-chip microcontroller, wherein the output matrix module, discharge prevention mould
Block, charging module, R wave detection module and PC machine connect to power supply.
Further, 1 pin of the output matrix module is connect with 1 pin of transformer T1, the output matrix mould
2 pins of block are connect with 2 pins of transformer T1.
Further, 3 pins of the transformer T1 draw with the 1 of 4 pins of discharge prevention module and charging module respectively
Foot connection, 1 pin of the 4 pins connection current transformer T2 of the transformer T1.
Further, 2 pins of the current transformer T2 are separately connected 1 pin and discharge switch of discharge prevention module
The left end of S1 connects, and 3 pins of the current transformer T2 and 2 pins of discharge prevention module connect, the current transformer
4 pins of T2 and 3 pins of discharge prevention module connect.
Further, the lower end of the right end of the discharge switch S1 and 2 pins of charging module and discharge capacity C1 connects.
Further, 1 pin of the upper end of the discharge capacity C1 and charging module connects.
Beneficial effects of the present invention：The present invention is used cooperatively by discharge prevention module and capacitor, can be lost in output
Achieve the effect that protect circuit when control and power down；The present invention, can not only by the use of output transformer and current transformer
It enough realizes discharge electrode and interlock circuit and other circuits to be electrically isolated, additionally it is possible to improve the working condition and EMC performance of element；
Simultaneously the present invention also with high security, the advantages of good stability.
Detailed description of the invention
It in order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, below will be to institute in embodiment
Attached drawing to be used is needed to be briefly described, it should be apparent that, the accompanying drawings in the following description is only some implementations of the invention
Example, for those of ordinary skill in the art, without creative efforts, can also obtain according to these attached drawings
Obtain other attached drawings.
Fig. 1 is a kind of structural schematic diagram of the high voltage narrow pulse treatment system described according to embodiments of the present invention；
In figure：
1, output matrix module；2, discharge prevention module；3, single-chip microcontroller；4, R wave detection module；5, power supply；6, PC machine；7, it charges
Module.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art's every other embodiment obtained belong to what the present invention protected
Range.
As shown in Figure 1, a kind of high voltage narrow pulse treatment system according to embodiments of the present invention, including with electrode unit
The output matrix module 1 and power supply 5 of connection, the output matrix module 1 are connected with transformer T1, and the transformer T1 connects respectively
Discharge prevention module 2 and current transformer T2 are connect, the discharge prevention module 2 and current transformer T2 connect with discharge switch S1
Connect, the discharge switch S1 is connected separately with charge and discharge capacitance C1, charging module 7 and single-chip microcontroller 3, the charging module 7 with put
Capacitor C1 is in parallel, and the single-chip microcontroller 3 is connect with charging module 7, and R wave detection module 4 is also respectively connected in the single-chip microcontroller 3
With PC machine 6, wherein the output matrix module 1, discharge prevention module 2, charging module 7, R wave detection module 4 and PC machine 6 are equal
It is connect with power supply 5.
In one embodiment, 1 pin of the output matrix module 1 is connect with 1 pin of transformer T1, described defeated
2 pins of matrix module 1 are connect with 2 pins of transformer T1 out.
In one embodiment, 3 pins of the transformer T1 respectively with 4 pins of discharge prevention module 2 and charging
1 pin of module 7 connects, 1 pin of the 4 pins connection current transformer T2 of the transformer T1.
In one embodiment, 2 pins of the current transformer T2 are separately connected 1 pin of discharge prevention module 2
It is connected with the left end of discharge switch S1,3 pins of the current transformer T2 are connect with 2 pins of discharge prevention module 2, described
4 pins of current transformer T2 are connect with 3 pins of discharge prevention module 2.
In one embodiment, the right end of the discharge switch S1 and 2 pins of charging module 7 and discharge capacity C1
Lower end connection.
In one embodiment, the upper end of the discharge capacity C1 is connect with 1 pin of charging module 7.
In one embodiment, the transformer T1 is special designing, can play boosting output, security isolation and arteries and veins
Width protective effect out of control；The discharge switch S1 is preferably but not limited to IGBT；7 output voltage of charging module is ladder
Shape can simultaneously automatically switch between a ladder, and the charging process to guarantee C1 is steady, and this system is preferably but not limited to as 100V,
300V, 450V three-level.
In order to facilitate understanding above-mentioned technical proposal of the invention, below by way of in specifically used mode to of the invention above-mentioned
Technical solution is described in detail.
When specifically used, the present invention uses output transformer and output current transformer；It can make discharge electrode and phase
Powered-down road and other circuits, which are realized, to be electrically isolated, and guarantees discharge electrode and power supply and other electricity using the insulation system that it is strengthened
Dielectric strength between road；Simultaneously by using output transformer, make when discharge time overlength because magnetic circuit saturation leads to output voltage
Sharply decline and storage capacitor repid discharge.
The present invention is provided with storage capacitor discharge protection circuit, i.e., is made of discharge capacity C1 and discharge prevention module；?
Once there is output electrode discharge time more than preset longest discharge time, i.e. automatic trigger, repid discharge, to ensure to export
Energy does not transfinite value；Automatically start the electric discharge to storage capacitor when shutdown simultaneously or power down, can drop capacitance voltage in 60 seconds
To safe voltage hereinafter, achieving the effect that protect circuit.
The present invention is provided with energy storage capacitor charging circuit：Specially designed transformer inverse-excitation type charging circuit is used, is made
It can rise with storage capacitor voltage carries out No-contact switch to transformer output tapping automatically, to effectively prevent becoming
Depressor core sataration shortens the storage capacitor charging time, while improving element manipulation state and EMC performance.
The present invention plans therapeutic scheme by computer dependent program first, then by special facilities when specifically used
Auxiliary electrode merging；Secondly, check and evaluation electrode places situation before the treatment by low-voltage discharge between each pair of electrode, make a reservation for
Discharge voltage；Tissue resistance between electrode is calculated by output voltage, current sample in treatment, is worn with assessing region of discharge cell
Hole degree, while independent therapeutic process energy accumulation and temperature rise estimation program are set, to ensure treatment region overheat do not occur.
The present invention is the system for treating tumour using IRE technology, wherein IRE technology full name is irreversible electroporation technology
(irreversibleelectroporation, IRE), principle are the impulse electric field for applying doses to cell, lipid
Double-layer cell film will appear many micropores and of short duration permeability increases, and this bioelectromagnetics phenomenon is known as electroporation
(electroporation).If cell membrane cannot be restored to normal physiological condition after the revocation of applying pulse electric field, that is, it is known as
IRE (also known as irreversible electrical breakdown), irreversible cell membrane damage will lead to Apoptosis, this is IRE technology diagnosis and treatment tumour
Main mechanism.
It is unlike radio frequency ablation and the like, heat will not be generated using IRE technology treatment tumour, therefore be more applicable for big blood vessel
The ablation diagnosis and treatment of Tumors, and for the tissue and nerve more containing collagen, damage is not likely to produce using IRE technology, because
This is more suitable for the diagnosis and treatment that tradition warm melts dangerous lesion.It is short using the IRE technology treatment tumour time, it is only necessary to the several seconds, but due to
The high voltage pulse of KV level can induce contraction of muscle and arrhythmia cordis, it is therefore desirable to general anesthesia and of flaccid muscles.IRE at present
Diagnosis and treatment tumour is in the preclinical study stage, but has been achieved for good effect in animal experiments.
In conclusion the present invention being used cooperatively by discharge prevention module and capacitor, can export out of control and fall
Achieve the effect that protect circuit when electric；The present invention can not only make to discharge by the use of output transformer and current transformer
Electrode and interlock circuit and other circuits, which are realized, to be electrically isolated, additionally it is possible to improve the working condition and EMC performance of element；This hair simultaneously
It is bright also with high security, the advantages of good stability.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of high voltage narrow pulse treatment system, which is characterized in that including the output matrix module being connect with electrode unit（1）With
Power supply（5）, the output matrix module（1）It is connected with transformer T1, the transformer T1 is separately connected discharge prevention module（2）
With current transformer T2, the discharge prevention module（2）It is connect with discharge switch S1 with current transformer T2, the electric discharge is opened
It closes S1 and is connected separately with charge and discharge capacitance C1, charging module（7）And single-chip microcontroller（3）, the charging module（7）With discharge capacity C1
Parallel connection, and the single-chip microcontroller（3）With charging module（7）Connection, the single-chip microcontroller（3）R wave detection module is also respectively connected（4）
And PC machine（6）, wherein the output matrix module（1）, discharge prevention module（2）, charging module（7）, R wave detection module（4）
And PC machine（6）And power supply（5）Connection.
2. a kind of high voltage narrow pulse treatment system according to claim 1, which is characterized in that the output matrix module
（1）1 pin connect with 1 pin of transformer T1, the output matrix module（1）2 pins and transformer T1 2 pins connect
It connects.
3. a kind of high voltage narrow pulse treatment system according to claim 1, which is characterized in that draw the 3 of the transformer T1
Foot respectively with discharge prevention module（2）4 pins and charging module（7）The connection of 1 pin, 4 pins of the transformer T1 connect
Connect 1 pin of current transformer T2.
4. a kind of high voltage narrow pulse treatment system according to claim 1, which is characterized in that the current transformer T2's
2 pins are separately connected discharge prevention module（2）1 pin connected with the left end of discharge switch S1, the 3 of the current transformer T2
Pin and discharge prevention module（2）2 pins connection, 4 pins and discharge prevention module of the current transformer T2（2）3
Pin connection.
5. a kind of high voltage narrow pulse treatment system according to claim 3, which is characterized in that the right side of the discharge switch S1
End and charging module（7）2 pins connected with the lower end of discharge capacity C1.
6. a kind of high voltage narrow pulse treatment system according to claim 5, which is characterized in that the discharge capacity C1's is upper
End and charging module（7）1 pin connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810382380.8A CN108853719A (en) | 2018-04-26 | 2018-04-26 | A kind of high voltage narrow pulse treatment system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810382380.8A CN108853719A (en) | 2018-04-26 | 2018-04-26 | A kind of high voltage narrow pulse treatment system |
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| CN108853719A true CN108853719A (en) | 2018-11-23 |
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| CN201810382380.8A Pending CN108853719A (en) | 2018-04-26 | 2018-04-26 | A kind of high voltage narrow pulse treatment system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274116A (en) * | 2021-05-12 | 2021-08-20 | 香港普创生物科技有限公司 | Full-automatic electric pulse perforation syringe |
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|---|---|---|---|---|
| CN101085391A (en) * | 2007-06-29 | 2007-12-12 | 重庆大学 | Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse |
| CN201073510Y (en) * | 2007-09-13 | 2008-06-18 | 复旦大学 | High-voltage impulse generating circuit suitable for external defibrillator |
| CN105055015A (en) * | 2015-08-05 | 2015-11-18 | 天津市鹰泰利安康医疗科技有限责任公司 | Irreversible electroporation system |
| CN106715682A (en) * | 2014-05-12 | 2017-05-24 | 弗吉尼亚暨州立大学知识产权公司 | Selective modulation of intracellular effects of cells using pulsed electric fields |
| CN106725451A (en) * | 2016-12-30 | 2017-05-31 | 天津市鹰泰利安康医疗科技有限责任公司 | A kind of human body electrocardio R ripple detecting systems |
-
2018
- 2018-04-26 CN CN201810382380.8A patent/CN108853719A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085391A (en) * | 2007-06-29 | 2007-12-12 | 重庆大学 | Device for inducing tumor cell apoptosis by high-voltage nanosecond pulse |
| CN201073510Y (en) * | 2007-09-13 | 2008-06-18 | 复旦大学 | High-voltage impulse generating circuit suitable for external defibrillator |
| CN106715682A (en) * | 2014-05-12 | 2017-05-24 | 弗吉尼亚暨州立大学知识产权公司 | Selective modulation of intracellular effects of cells using pulsed electric fields |
| CN105055015A (en) * | 2015-08-05 | 2015-11-18 | 天津市鹰泰利安康医疗科技有限责任公司 | Irreversible electroporation system |
| CN106725451A (en) * | 2016-12-30 | 2017-05-31 | 天津市鹰泰利安康医疗科技有限责任公司 | A kind of human body electrocardio R ripple detecting systems |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274116A (en) * | 2021-05-12 | 2021-08-20 | 香港普创生物科技有限公司 | Full-automatic electric pulse perforation syringe |
| CN113274116B (en) * | 2021-05-12 | 2024-05-14 | 普亚生物科技有限公司 | Full-automatic electroporation syringe |
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Application publication date: 20181123 |
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