CN108853167A - A kind of hemorrhoid composition containing chitosan, preparation method and applications - Google Patents
A kind of hemorrhoid composition containing chitosan, preparation method and applications Download PDFInfo
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Abstract
The present invention relates to a kind of hemorrhoid composition containing chitosan, preparation method and applications, belongs to field of medicaments.In order to overcome the analgesic effect of hemorrhoid treating medicine in the prior art and the bad technical deficiency of antiphlogistic effects, the present invention provides a kind of hemorrhoid composition containing chitosan comprising the component of following weight percentage：Chitosan 1%-10%, alum 0.5%-5%, borneol 0.1-2%, carbomer 1%-10%, glycerol 2%~4%, propylene glycol 2%~4%, triethanolamine 2%~4%, gelatin 20~40%, Sodium Hyaluronate 1%~5% and 30~70% water；Hemorrhoid composition provided by the invention containing chitosan is prepared into suppository, compared with prior art, there is significant detumescence, analgesia, promote ulcer healing and anastalsis, there is significant therapeutic effect to hemorrhoid, significant progress is achieved, a wide range of promote and apply is suitable for.
Description
Technical field
The present invention relates to a kind of hemorrhoid composition containing chitosan, preparation method and applications, belongs to field of medicaments.
Background technique
Hemorrhoid are a kind of common diseases positioned at anus area, and any age can all fall ill, but with age, morbidity
Rate gradually increases.In China, hemorrhoid are the most common anorectal diseases.Hemorrhoid are divided into internal piles, external piles, mixing by the difference of happening part
Hemorrhoid.There is a jagged visible line anal canal dentate line in the junction of anal canal skin and rectal mucosa.Dentate line with
On be internal piles, be support structure, veniplex and arteriovenous anastomosis Zhi Fasheng pathological change or the displacement of anus pad, it is glutinous to be coated rectum
Film, since internal sphincter is shunk, anus pad is divided into left side, forward right side, three pieces of right lateral side with Y type ditch, thus internal piles be common on the left of,
Forward right side and right lateral side；In dentate line, the following are external piles, are coated anal canal mucous membrane, can be divided into connective tissue external piles, varication
Property external piles, thrombosed external hemorrhoid；It has internal piles concurrently and external piles is mixed hemorrhoid, be that internal piles is merged by veniplex with corresponding external piles,
I.e. upper and lower veniplex coincide, and mixed hemorrhoid is deviate from outside anus, when being in plum blossom-shaped, referred to as annular hemorrhoid, if by sphincter incarceration, shape
At strangulated hemorrhoid.
Externally applied drug occupies certain scale in hospital market.Wherein, suppository is that specific gravity is maximum in the market for external application drug for haemorrhoid
Dosage form, main cause are that suppository administration is convenient, can directly act on hemorrhoid position, absorption is fast and comprehensive, there is the effect of moisturizing, effect
Bigger performance can be obtained, therefore, hemorrhoid suppositories are commonplace in clinical use.Other than suppository, ointment and cream pair
External piles effect preferably, alsies occupy one seat, and the two accounts for 35.20%, 12.24% respectively on the market, and it is opposite to belong to sale
Popular dosage form.Ten kinds are before sales volume in the market：Horse-chestnut seed extract piece, diosmin piece, compound folium ginkgo extraction
Composite capsule, the immersion liquid of sweet clover stream, compound carraghenates, PuJi BenShi Fang, bismuth subgallate, MAYINGLONGZHICHUANGGAO, White Cloud Mountain
Respect and repairs a HUAZHI SHUAN, Mayinglong musk hemorrhoids suppository.Preceding ten kind occupies 98% or so share of sample hospital hemorrhoid medicine market.Additionally
There are inactivation angstrom uncommon pine, Jiuhua Zhichuang Shuan, Indomethacin Roptazol suppository, xiaozhiling injection, the jiuhua plaster etc. of German doctor Ka De.But
The external application Chinese medicine suppository of existing market lacks the repair to the surface of a wound based on moisturizing, and these drug ingedients are complicated, past
It is past to bring some negative consequences.It is therefore desirable to develop a kind of wound repair effect preferably and the hemorrhoid of definite ingredients,
Therefore propose the present invention.
Chinese invention patent 201310355429.8 is related to the formula and preparation process of a kind of chitosan iodine bolt, and feature exists
In：By weight, formula includes consisting of：Chitosan iodine 8~15%, Potassiumiodate 0.1~2%, chitosan 0.1~1%,
Hydrophilic matrix 20~50%, hydroxyethyl cellulose 1~10%, glacial acetic acid 0.05~0.5%, purified water 30~70%.The hair
The more other dosage form effects of bright chitosan iodine suppository are more effective lasting, but it is bad for the therapeutic effect of hemorrhoid.
It is multiple that Chinese invention patent 200910017600.8 discloses a kind of silver, chitosan and/or chitosan derivatives nanometer
Object and preparation method thereof is closed, is to mix chitosan and/or chitosan derivatives fine powder and silver nitrate fine powder, is fully ground 1
~3 hours, the weight ratio of chitosan and/or chitosan derivatives and silver nitrate was 100: 0.0005~0.5；Reduction is added
The reducing equivalent ratio of agent, reducing agent and silver nitrate be 1: 1~2: 1, be fully ground 2~6 hours to get silver granuel diameter be 1~100NM
Silver, chitosan and/or chitosan derivatives nano-complex, be prepared into nano-complex be conducive to the surface of a wound absorption,
But the compatibility of chitosan and silver granuel is bad, and the two cooperates so that its antibacterial effect substantially reduces.
Summary of the invention
In order to overcome the analgesic effect of hemorrhoid treating medicine in the prior art and the bad defect of antiphlogistic effects, the present invention is mentioned
For a kind of hemorrhoid composition containing chitosan, containing there are many drug components as its active constituent, each group split-phase in the suppository
Interaction has hemorrhoid significant with significant synergistic effect in terms of detumescence, analgesia, promoting ulcer healing and hemostasis
Therapeutic effect, and its drug safety is appropriate for promoting and applying.
The present invention provides a kind of hemorrhoid composition containing chitosan comprising the component of following weight percentage：Shell
Glycan 1%-10%, alum 0.5%-5%, borneol 0.1-2%, carbomer 1%-10%, glycerol 2%~4%, propylene glycol 2%
~4%, triethanolamine 2%~4%, gelatin 20~40%, Sodium Hyaluronate 1%~5%, excess water.
Preferably, the hemorrhoid composition containing chitosan includes the component of following weight percentage：Chitosan
3-8%, alum 1-3%, borneol 0.5-1.5%, carbomer 3-8%, glycerol 2-3%, propylene glycol 2-3%, triethanolamine 2-
3%, gelatin 25-30%, Sodium Hyaluronate 2-3%, excess water.
Preferably, the hemorrhoid composition containing chitosan is prepared by the component of following weight percentage：
Chitosan 5.5%, alum 2.75%, borneol 1%, carbomer 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin
30%, Sodium Hyaluronate 3%, excess water.
The hemorrhoid composition containing chitosan can also contain oriental wormwood parthenium extract, wherein the Artemisia capillaris extracts
Preparation method in object is：
Take dry Artemisia capillaris be crushed into powder it is last be put into triangular flask, be added temperature be 30 DEG C~50 DEG C, mass concentration is
60%~80% ethyl alcohol pre-soaking 30 minutes, be then added mentioned 6~12 times of quality of material, temperature be 50 DEG C~80 DEG C, quality
The ethanol water that concentration is 5%~20%, and the pressure in triangular flask is reduced to 0.02MPa~0.03MPa, realize internal boiling
It rises reinforcing to extract, extract 1~4 minute, extract 2~4 times, combined extract, and the extracting solution after merging is subjected to centrifugation or mistake
Filter extracting solution；Acticarbon is added into Artemisia capillaris extracting solution, is stood at 50 DEG C, is centrifuged or filters, then by gained
Solution is concentrated into paste, and the 6-8 times of dehydrated alcohol reflux for measuring volume that its quality is added is dissolved, and discards filter residue after filtering,
Phegma is concentrated under reduced pressure into paste, dry to get oriental wormwood parthenium extract.
Hemorrhoid composition containing chitosan as described above, the hemorrhoid composition is suppository, in the suppository
The weight ratio of chitosan and oriental wormwood parthenium extract is 1:2.
The hemorrhoid composition containing chitosan also includes matrix, and the dosage of the matrix can add according to pharmaceutical quantities
Add, content does not have an impact the therapeutic effect of drug.The matrix be semi-synthetic fatty glyceride, cocoa butter,
One of Myrj 45, hydrogenated vegetable oil, glycerin gelatine, polyethylene glycols are a variety of.It is preferable to use cocoa beans
Rouge.
The preparation method of the hemorrhoid composition containing chitosan is：Take each group of the hemorrhoid composition of chitosan-containing
Point grind well to obtain drug solution after mixing in mortar, water-bath melts matrix, and drug solution is added, and mixes, cool to
Slightly sticky thick, injection bolt mould places solidification and is placed on refrigerator cold-storage, take out scraping, demoulds to get suppository.
Chitosan, alum, oriental wormwood parthenium extract and hyalomitome sodium, which can play, in prescription of the present invention significantly cooperates with
Detumescence, analgesia and promotion ulcer healing effect, unexpected technical results have been achieved.
The present invention is also claimed the above-mentioned hemorrhoid composition containing chitosan and is preparing the application in medicine for treaching hemorrhoie.
The present invention achieves following technical effect compared with the existing technology：
Hemorrhoid composition provided by the invention containing chitosan prepares suppository, compared with prior art, has significant
Hemorrhoid are had significant therapeutic effect, achieve significant progress, are suitable for big by detumescence, analgesia and promotion ulcer healing effect
Range promotes and applies.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the embodiment does not limit this hair in any way
Bright scope of patent protection.
Embodiment 1, the hemorrhoid composition containing chitosan
A kind of hemorrhoid composition containing chitosan, is prepared by the component of following weight percentage：Chitosan
1%, alum 0.5%, borneol 0.1%, carbomer 1%, glycerol 2%, propylene glycol 2%, triethanolamine 2%, gelatin 20%, transparent
Matter acid sodium 1%, excess water.
The preparation method of the hemorrhoid composition containing chitosan is：Weigh the chitosan, alum, ice of recipe quantity
Piece, carbomer, glycerol, propylene glycol, triethanolamine, gelatin, Sodium Hyaluronate and water grind well to obtain after mixing in mortar
Drug solution, 80 DEG C of water-baths melt its cocoa butter, and drug solution is added, and mix, and cool to slightly sticky thick, injection bolt mould is put
It sets solidification and is placed on refrigerator cold-storage 20min, take out scraping, demould to get the hemorrhoid composition containing chitosan.
Embodiment 2, the hemorrhoid composition containing chitosan
A kind of hemorrhoid composition containing chitosan, is prepared by the component of following weight percentage：Chitosan
5.5%, alum 2.75%, borneol 1%, carbomer 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin 30%,
Sodium Hyaluronate 3%, excess water.
The preparation method is the same as that of Example 1 for the hemorrhoid composition containing chitosan.
Embodiment 3, the hemorrhoid composition containing chitosan
A kind of hemorrhoid composition containing chitosan, is prepared by the component of following weight percentage：Chitosan
10%, alum 5%, borneol 2%, carbomer 10%, glycerol 4%, propylene glycol 4%, triethanolamine 4%, gelatin 40%, hyalomitome
Sour sodium 5%, excess water.
The preparation method is the same as that of Example 1 for the hemorrhoid composition containing chitosan.
Embodiment 4, the hemorrhoid composition containing chitosan
A kind of hemorrhoid composition containing chitosan, is prepared by the component of following weight percentage：Chitosan
1%, alum 0.5%, borneol 0.1%, carbomer 1%, glycerol 2%, propylene glycol 2%, triethanolamine 2%, gelatin 20%, transparent
Matter acid sodium 1%, oriental wormwood parthenium extract 2%, excess water.
Wherein the preparation method in the Artemisia capillaris extract is：
Take dry Artemisia capillaris be crushed into powder it is last be put into triangular flask, be added temperature be it is 30 dry, mass concentration is 60% second
Alcohol pre-soaking 30 minutes, the ethanol water for being mentioned 6 times of quality of material, temperature is 50 DEG C, mass concentration is 5% is then added,
And the pressure in triangular flask is reduced to 0.02MPa, it realizes that inner ebullition is strengthened and extracts, extract 1 minute, extract 2 times, merge and extract
Liquid, and the extracting solution after merging is centrifuged or is filtered extracting solution；Acticarbon is added into Artemisia capillaris extracting solution,
60 DEG C stand 3 hours, then acquired solution is concentrated into paste by centrifugation or filtering, and 6 times of amount volumes of its quality are added
Dehydrated alcohol reflux dissolution discards filter residue after filtering, phegma is concentrated under reduced pressure into paste, dry to get oriental wormwood parthenium extract.
The preparation method of the hemorrhoid composition containing chitosan is：Weigh the chitosan, alum, ice of recipe quantity
Piece, carbomer, glycerol, propylene glycol, triethanolamine, gelatin, Sodium Hyaluronate, oriental wormwood parthenium extract and water are after mixing in grinding
Grinding well to obtain drug solution in alms bowl, 80 DEG C of water-baths melt its cocoa butter, and drug solution is added, and mix, it cools to slightly sticky thick,
Injection bolt mould places solidification and is placed on refrigerator cold-storage 20min, takes out scraping, demoulds to get the hemorrhoid combination containing chitosan
Object.
Embodiment 5, the hemorrhoid composition containing chitosan
A kind of hemorrhoid composition containing chitosan is prepared by the component for including following weight percentage：Shell
Glycan 5.5%, alum 2.75%, borneol 1%, carbomer 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin
30%, Sodium Hyaluronate 3%, oriental wormwood parthenium extract 10%, excess water.
Wherein the preparation method in the Artemisia capillaris extract is：
Take dry Artemisia capillaris be crushed into powder it is last be put into triangular flask, be added temperature be 40 DEG C, mass concentration is 70% second
Alcohol pre-soaking 30 minutes, the ethanol water for being mentioned 9 times of quality of material, temperature is 65 DEG C, mass concentration is 15% is then added,
And the pressure in triangular flask is reduced to 0.02MPa~0.03MPa, it realizes that inner ebullition is strengthened and extracts, extract 4 minutes, extract 3
It is secondary, combined extract, and the extracting solution after merging is centrifuged or is filtered extracting solution；Activity is added into Artemisia capillaris extracting solution
Carbon adsorbent stands 3 hours at 60 DEG C, then acquired solution is concentrated into paste, its quality is added by centrifugation or filtering
The dehydrated alcohol of 7 times of amount volumes, which flows back, to be dissolved, and filter residue is discarded after filtering, phegma is concentrated under reduced pressure into paste, dry to get mattress
Old parthenium extract.
The preparation method of the hemorrhoid composition containing chitosan is the same as embodiment 4.
Embodiment 6, the hemorrhoid composition containing chitosan
A kind of hemorrhoid composition containing chitosan is prepared by the component for including following weight percentage：Shell
Glycan 10%, alum 5%, borneol 2%, carbomer 10%, glycerol 4%, propylene glycol 4%, triethanolamine 4%, gelatin 40%, thoroughly
Bright matter acid sodium 5%, oriental wormwood parthenium extract 20%, excess water.
Wherein the preparation method in the Artemisia capillaris extract is：
Take dry Artemisia capillaris be crushed into powder it is last be put into triangular flask, be added temperature be 50 DEG C, mass concentration is 80% second
Alcohol pre-soaking 30 minutes, the ethyl alcohol for being mentioned 12 times of quality of material, temperature is 80 DEG C, mass concentration is 5%~20% is then added
Aqueous solution, and the pressure in triangular flask is reduced to 0.03MPa, it realizes that inner ebullition is strengthened and extracts, extract 3 minutes, extract 2 times,
Combined extract, and the extracting solution after merging is centrifuged or is filtered extracting solution；Active carbon is added into Artemisia capillaris extracting solution
Adsorbent stands 3 hours at 70 DEG C, then acquired solution is concentrated into paste, the 8 of its quality are added by centrifugation or filtering
The dehydrated alcohol of amount volume, which flows back, again dissolves, and filter residue is discarded after filtering, phegma is concentrated under reduced pressure into paste, dry to get mattress
Old parthenium extract.
The preparation method is the same as that of Example 1 for the hemorrhoid composition containing chitosan.
Comparative example 1, hemorrhoid composition
A kind of hemorrhoid composition is prepared by the component for including following weight percentage：Alum 8.25%, borneol
1%, carbomer 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin 30%, Sodium Hyaluronate 3%, Artemisia capillaris mentions
Take object 10%, excess water.
Remaining is the same as embodiment 5.
Comparative example 2, hemorrhoid composition
A kind of hemorrhoid composition containing chitosan is prepared by the component for including following weight percentage：
Chitosan 8.25%, borneol 1%, carbomer 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin
30%, Sodium Hyaluronate 3%, oriental wormwood parthenium extract 10%, excess water.
Remaining is the same as embodiment 5.
Comparative example 3, hemorrhoid composition
A kind of hemorrhoid composition containing chitosan is prepared by the component for including following weight percentage：Shell
It is glycan 5.5%, alum 2.75%, carbomer 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin 30%, transparent
Matter acid sodium 3%, oriental wormwood parthenium extract 10%, excess water.
Remaining is the same as embodiment 5
Comparative example 4, chitosan bolt
The chitosan bolt being prepared according to 201310355429.8 embodiment 1 of Chinese patent application.
Test example one, suppository of the present invention ease pain effect
1.1 test specimen：Example 1~6 and the composition of comparative example 1~4, are added appropriate cocoa butter, system
It is standby to obtain corresponding suppository.
The production of 1.2 mouse hot-plate pain models
Weight 20g or so female mice is placed on hot plate pain threshold detector, screening qualification ♀ mouse 90 (licks the metapedes time
<5s or>30s is thrown aside, and to prevent foot from scalding, should also set deadline, generally 60s), the latent of metapedes reaction is added with mouse
Phase is pain indicator, takes 120 jennies, is divided into 12 groups, 10/group, blank control group refuses any processing, and model group is given
Give the bare substrate bolt of equivalent, remaining group smears relative medicine, and 60min, 120min add after measurement administration reacts enough
Time.
Influence of 1.3 suppositorys of the present invention to the sufficient response latency is licked in mouse hot-plate analgesic experiment
Mouse licks sufficient response latency time showing, compared with model group, 1h after the administration of 1~6 suppository of the embodiment of the present invention
After 2h, the mouse of each administration group licks the incubation period reacted enough and is all larger than model group, illustrates 1~6 suppository of the embodiment of the present invention
It is able to extend mouse and licks the sufficient response latency to what hot plate stimulated, there is certain analgesic activity.This shows hemorrhoid composition each group
Divide to be used in combination and there is significant synergistic effect in ease pain, the analgesic effect of suppository of the present invention is created better than existing chitosan
Mouth repairs product, the results are shown in Table 1.
1 mouse of table licks sufficient response latency timetable
Note：Compared with blank control group,#P < 0.05,##P < 0.01；Model group compares,*P < 0.05,**P < 0.01, with
5 groups of embodiment are compared, ^P < 0.05, ^^P < 0.01^.
Test example two, suppository of the present invention cause the detumescence effect of rat anus swelling to croton oil
It investigates the embodiment of the present invention 1~6 and 1~4 suppository of comparative example and causes the detumescence of rat anus swelling to make croton oil
With test result is as shown in table 2 below.
2 Examples 1 to 6 of table and 1~4 suppository of comparative example cause the effect of rat anus swelling to croton oil
| Group | Dosage (mg/kg) | Swelling rate (0%) | Evans blue leaching content (μ g/ rectal tissue g) |
| Blank control group | - | 75.2±6.35 | 23.6±3.21 |
| Model group | - | 89.5±4.21## | 225.3±65.53## |
| Embodiment 1 | 300 | 83.6±2.71* | 146.7±38.44* |
| Embodiment 2 | 300 | 82.0±5.38* | 133.1±34.26* |
| Embodiment 3 | 300 | 81.3±4.52* | 128.5±30.52* |
| Embodiment 4 | 300 | 80.4±2.73** | 92.6±33.28** |
| Embodiment 5 | 300 | 77.6±5.06** | 80.4±22.15** |
| Embodiment 6 | 300 | 78.7±3.45** | 86.5±35.43** |
| Comparative example 1 | 300 | 87.5±6.92^ | 145.2±55.37^ |
| Comparative example 2 | 300 | 83.2±5.48^ | 121.6±44.8^ |
| Comparative example 3 | 300 | 80.7±7.05 | 102.1±32.7^ |
| Comparative example 4 | 300 | 82.4±4.12^ | 106.7±22.36^ |
Note：Compared with blank control group,#P < 0.05,##P < 0.01；Model group compares,*P < 0.05,**P < 0.01, with
5 groups of embodiment are compared, ^P < 0.05, ^^P < 0.01.
The effect of test example three, suppository of the present invention in terms of promoting ulcer healing
The embodiment of the present invention 1~6 and 1~4 suppository of comparative example are investigated in the effect for promoting ulcer healing and antibiosis,
For dosage according to test example two, test result is as shown in table 3 below.
3 Examples 1 to 6 of table and 1~4 suppository of comparative example are in the effect for promoting ulcer healing and antibiosis
Note：Compared with model group,*P < 0.05,**P < 0.01, compared with 5 groups of embodiment, ^P < 0.05, ^^P <
0.01。。
The effect of test example four, suppository of the present invention in terms of hemostasis
Investigate the effect of the embodiment of the present invention 1~6 and 1~4 suppository of comparative example in terms of hemostasis, test result such as following table
Shown in 4.
The influence of 4 Examples 1 to 6 of table and 1~4 suppository of comparative example to mouse clotting time and bleeding time
| Group | Dosage (mg/kg) | Bleeding time (s) | Clotting time (s) |
| Model group | - | 212±35.3 | 159±26.7 |
| Embodiment 1 | 300 | 171±27.9* | 127±12.2* |
| Embodiment 2 | 300 | 168±26.2* | 125±23.8* |
| Embodiment 3 | 300 | 162±28.4* | 124±18.9* |
| Embodiment 4 | 300 | 126±33.4** | 103±21.5** |
| Embodiment 5 | 300 | 115±26.7** | 92±18.6** |
| Embodiment 6 | 300 | 122±41.6** | 98±22.4** |
| Comparative example 1 | 300 | 170±21.5^ | 121±20.5^ |
| Comparative example 2 | 300 | 146±15.5^ | 113±20.4^ |
| Comparative example 3 | 300 | 130±34.1^ | 109±20.6^ |
| Comparative example 4 | 300 | 135±25.0^ | 119±21.6^ |
Note：Compared with model group,*P < 0.05,**P < 0.01, compared with 5 groups of embodiment, ^P < 0.05, ^^P < 0.01.
The results show that suppository of the present invention has excellent detumescence, promotes ulcer healing, hemostasis and analgesic effect, show
Shown its to the significant curative effect of hemorrhoid, and by compare each group experimental result it is found that above-mentioned effect is by various Chinese medicine groups
What the synergistic effect divided was realized, unexpected technical results have been achieved.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of hemorrhoid composition containing chitosan comprising the component of following weight percentage：Chitosan 1%-10%,
Alum 0.5%-5%, borneol 0.1-2%, carbomer 1%-10%, glycerol 2%~4%, propylene glycol 2%~4%, triethanolamine
2%~4%, gelatin 20~40%, Sodium Hyaluronate 1%~5% and 30~70% water.
2. the hemorrhoid composition according to claim 1 containing chitosan, which is characterized in that described containing chitosan
Hemorrhoid composition includes the component of following weight percentage：Chitosan 3-8%, alum 1-3%, borneol 0.5-1.5%, card wave
Nurse 3-8%, glycerol 2-3%, propylene glycol 2-3%, triethanolamine 2-3%, gelatin 25-30%, Sodium Hyaluronate 2-3% and 30~
60% water.
3. the hemorrhoid composition according to claim 2 containing chitosan, which is characterized in that described containing chitosan
Hemorrhoid composition is prepared by the component of following weight percentage：Chitosan 5.5%, alum 2.75%, borneol 1%, card
Wave nurse 5.5%, glycerol 3%, propylene glycol 3%, triethanolamine 3%, gelatin 30%, Sodium Hyaluronate 3% and excess water.
4. the hemorrhoid composition according to claim 1-3 containing chitosan, which is characterized in that described contains
The hemorrhoid composition of chitosan further includes oriental wormwood parthenium extract.
5. the hemorrhoid composition according to claim 4 containing chitosan, which is characterized in that the oriental wormwood parthenium extract
Preparation method is：
Take dry Artemisia capillaris be crushed into powder it is last be put into triangular flask, be added temperature be 30 DEG C~50 DEG C, mass concentration 60%
~80% ethyl alcohol pre-soaking 30 minutes, be then added mentioned 6~12 times of quality of material, temperature be 50 DEG C~80 DEG C, mass concentration
For 5%~20% ethanol water, and the pressure in triangular flask is reduced to 0.02MPa~0.03MPa, realizes that inner ebullition is strong
Change and extract, extract 1~4 minute, extracts 2~4 times, combined extract, and the extracting solution after merging is centrifuged or is filtered and is mentioned
Take liquid；Acticarbon is added into Artemisia capillaris extracting solution, is stood at 50~70 DEG C, is centrifuged or filters, then by gained
Solution is concentrated into paste, and the 6-8 times of dehydrated alcohol reflux for measuring volume that its quality is added is dissolved, and discards filter residue after filtering,
Phegma is concentrated under reduced pressure into paste, dry to get oriental wormwood parthenium extract.
6. the hemorrhoid composition according to claim 4 containing chitosan, which is characterized in that chitosan and Artemisia capillaris extract
The weight fraction ratio of object is 1:2.
7. a kind of suppository of the hemorrhoid composition containing described in any one of claims 1-6 containing chitosan, which is characterized in that
It also include matrix, the matrix is semi-synthetic fatty glyceride, cocoa butter, Myrj 45, hydrogenated vegetable
One of oil, glycerin gelatine and polyethylene glycols are a variety of.
8. suppository according to claim 7, which is characterized in that the matrix is cocoa butter.
9. a kind of method for preparing suppository described in claim 7, which is characterized in that it specifically includes following step：
The each component of the hemorrhoid composition of chitosan-containing is taken to grind well to obtain drug solution after mixing in mortar, water-bath makes base
Matter melting, is added drug solution, mixes, and cools to slightly sticky thick, injection bolt mould, places solidification and is placed on refrigerator cold-storage, taking-up is scraped
It cuts, demoulds to get suppository.
10. any hemorrhoid composition containing chitosan as described in claim 1-6 or the suppository as described in claim 7 or 8
Preparing the application in medicine for treaching hemorrhoie.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451550A (en) * | 2020-12-18 | 2021-03-09 | 藏寿堂健康管理(武汉)有限公司 | Production process of cold-setting gel for hemorrhoids |
| CN115518031A (en) * | 2022-10-28 | 2022-12-27 | 云飞生物药业(吉林)有限公司 | Carbomer hemorrhoid gel |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973492A (en) * | 2011-09-02 | 2013-03-20 | 欧世文 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
| CN104027448A (en) * | 2014-04-16 | 2014-09-10 | 广西信业生物技术有限公司 | Chitosan gel and preparation method thereof |
| CN104043089A (en) * | 2014-06-27 | 2014-09-17 | 亳州正丰医药有限责任公司 | Medical biological dressing suppository for treating hemorrhoid |
-
2018
- 2018-09-13 CN CN201811065789.3A patent/CN108853167A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973492A (en) * | 2011-09-02 | 2013-03-20 | 欧世文 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
| CN104027448A (en) * | 2014-04-16 | 2014-09-10 | 广西信业生物技术有限公司 | Chitosan gel and preparation method thereof |
| CN104043089A (en) * | 2014-06-27 | 2014-09-17 | 亳州正丰医药有限责任公司 | Medical biological dressing suppository for treating hemorrhoid |
Non-Patent Citations (2)
| Title |
|---|
| 杨彤: "《美容药物学》", 30 April 2007, 中国医药科技出版社 * |
| 蔡永敏: "《最新中药药理与临床应用》", 31 January 1999, 华夏出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451550A (en) * | 2020-12-18 | 2021-03-09 | 藏寿堂健康管理(武汉)有限公司 | Production process of cold-setting gel for hemorrhoids |
| CN115518031A (en) * | 2022-10-28 | 2022-12-27 | 云飞生物药业(吉林)有限公司 | Carbomer hemorrhoid gel |
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