CN108852946A - A kind of rapid detumescence, sewing product and preparation method thereof that is antibacterial, repairing skin - Google Patents
A kind of rapid detumescence, sewing product and preparation method thereof that is antibacterial, repairing skin Download PDFInfo
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- CN108852946A CN108852946A CN201811086311.9A CN201811086311A CN108852946A CN 108852946 A CN108852946 A CN 108852946A CN 201811086311 A CN201811086311 A CN 201811086311A CN 108852946 A CN108852946 A CN 108852946A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
- A61Q1/145—Tattoo removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a kind of detumescences rapidly, sewing product that is antibacterial, repairing skin and preparation method thereof.The rapid detumescence, antibacterial, sewing product that is repairing skin include the raw material of following parts by weight：5~15 parts of Notogineng Extract, 10~20 parts of EGF, 3~7 parts of clindamycin, 15~25 parts of Sodium Hyaluronate and 45~55 parts of distilled water.Each material component effect mutually collaboration, lasting medicine of sewing product is significant for the recovery effects of skin after sewing.The preparation method is easy to operate, it is only necessary to uniformly mix each material component, process repeatability is strong, is conducive to scale output.
Description
Technical field
The invention belongs to sewing fields, and in particular to a kind of sewing product and its system for reducing swelling rapidly, is antibacterial, repairing skin
Preparation Method.
Background technique
Sewing is a kind of Micro trauma pigmenting of skin, belongs to medical and beauty treatment, it is that pigment is implanted into skin histology to be formed
Stable color lump, since epidermis is very thin, at translucent, so the pigment of implantation shows implantation color by epidermis, with
Have the function that cover flaw, maximizes favourable factors and minimizes unfavourable ones, modifies beautification.Pigment due to being pierced into skin is that fine granularity, diameter are all small
It in 1 micron, will soon be surrounded, can not be swallowed by phagocyte by collagen after implantation, to form half in skin surface
Permanent label.
Since sewing process is directly to puncture skin injection colorant, therefore the disinfection of corresponding site skin is with after after operating
Continuation of insurance is supported then extremely crucial.The patent of Publication No. CN107837209A proposes a kind of seamless cleaning solution of sewing, including water, sweet
Oil, butanediol, hydroxyethyl cellulose, Sodium Hyaluronate, arbutin, allantoin and Phenoxyethanol, the seamless cleaning solution of sewing
Seamless cleaning is realized, the injury to human body is reduced, while reducing the cost of removal sewing.However, the seamless cleaning
Liquid is only capable of single effect, not comprehensively, to limit its further genralrlization.
Summary of the invention
Of the existing technology in order to solve the problems, such as, the present invention provides a kind of detumescences rapidly, line that is antibacterial, repairing skin
Embroider product and preparation method thereof.The sewing product effect is comprehensive, organically by cleaning, detumescence, antibacterial and reparation four effect greatly
It is combined, has expanded audient crowd significantly.And the preparation method is easy to operate, it is only necessary to uniformly mix each material component and is
Can, process repeatability is strong, is conducive to scale output.
The solution of the present invention is to provide a kind of sewing product for reducing swelling rapidly, is antibacterial, repairing skin, including following weight
The raw material of part：5~15 parts of Notogineng Extract, 10~20 parts of EGF, 3~7 parts of clindamycin, 15~25 parts of Sodium Hyaluronate and steaming
45~55 parts of distilled water.
Preferably, the rapid detumescence, sewing product that is antibacterial, repairing skin, the raw material including following parts by weight：Three
Seven 10 parts of extracts, 15 parts of EGF, 5 parts of clindamycin, 20 parts of Sodium Hyaluronate and 50 parts of distilled water.
The conductivity size of distilled water and the wherein general correlation of content of mineral substances, to avoid distilled water Minerals
The influence of confrontation product stability is verified repeatedly through inventor, it is preferable that conductivity≤0.1mS/m of the distilled water.
It is easier to be dissolved in distilled water when extract granularity is thinner, it is contemplated that grinding cost is verified through inventor, excellent
Selection of land, when the Notogineng Extract granularity is 800~1000 mesh, grinding cost and solute effect reach optimum balance.
Preferably, the preparation method of the Sodium Hyaluronate includes the following steps：
(1) streptococcus zooepidemicus kind fermentation liquid is cultivated, enzyme deactivation, sterilizing is successively carried out after the completion, obtains sterilization fermentation liquid；
(2) diatomite is added in sterilization fermentation liquid, Sodium Hyaluronate is obtained after filtering.
Preferably, in step (1), the mode of the enzyme deactivation is：Hammer strain fermentating liquid is protected under the conditions of 70~80 DEG C
1~2h of temperature；The mode of the sterilizing is：The fermentation liquid after enzyme deactivation is added in trichloroacetic acid, being adjusted to system pH is 4.5~4.8.
Preferably, in step (2), the weight ratio of the diatomite and sterilization fermentation liquid is 1~2：100；The filtering
Temperature is 60~70 DEG C.
The present invention also provides a kind of detumescences rapidly, the preparation method of sewing product that is antibacterial, repairing skin：Each raw material is equal
Even mixing.
Preferably, the mixed uniformly revolving speed be 60~80r/min, it is described it is uniform mix the time be 20~30min.
The present invention also provides rapid detumescences, the application method of sewing product that is antibacterial, repairing skin：
(i) after color is pressed in supercilium sewing, drop coating 2~3 drips sewing product, is smeared back and forth with finger and takes away loose colour, then again
Secondary drop coating sewing product simultaneously applies preservative film and covers 10~15min, after red and swollen disappear.
(ii) when eye sewing press color after, dip sewing product with cotton swab and be uniformly applied to repeatedly informer position 3~
5min, then using preservative film cover 10~15min, after redness fade away.
(iii) it after color is pressed in lip sewing, takes sewing product to soak cotton piece and is lightly spread in labial surface, then covered with preservative film
15~20min, after redness rapidly disappear.
Beneficial effects of the present invention are：
1, rapid detumescence of the present invention, sewing product that is antibacterial, repairing skin, include plurality of active ingredients, wherein：
Notogineng Extract has the function of activating microcirculation and removing stasis medicinal, improves microcirculation, can eliminate dermatorrhagia, red and swollen phenomenon after sewing；Again
Since sewing is the minimally invasive implantation to skin, even if operation is rigorous again, also inevitably skin is damaged, therefore adds EGF and is directed to
Epidermal growth factor receptor is stimulated to property, has the function that repairing, hyperplasia skin surface cell, it is significant in efficacy single-minded；Together
When, it is contemplated that the damaged skin after sewing is highly prone to the infection of extraneous bacterium, and such as processing will cause inflammation not in time, and
Clindamycin in raw material can effectively quickly antibacterial, sterilization, be inherently eliminated the possibility of inflammation generation；That finally adds is saturating
The compatibility of bright matter acid sodium and skin is splendid, and Saccharideisomerate, can also extend material component in the action time of epidermis, effect
It is more lasting.To sum up gained, sewing product has effects that detumescence, sterilization, repairs epidermis skin, and persistent, effect are complete
Face.
2, the preparation method of the rapid sewing product reducing swelling, is antibacterial, repairing skin of the present invention, it is easy to operate, only
Each material component need to uniformly be mixed, process repeatability is strong, is conducive to scale output.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The present embodiment provides a kind of detumescences rapidly, the preparation method of sewing product that is antibacterial, repairing skin, including walk as follows
Suddenly：
(I) Sodium Hyaluronate is prepared, is included the following steps：
(1) streptococcus zooepidemicus kind fermentation liquid is cultivated, streptococcus zooepidemicus fermentation liquid is kept the temperature into 2h under the conditions of 70 DEG C after the completion
Afterwards, add trichloroacetic acid be adjusted to system pH be 4.5, sterilize, after sterilization fermentation liquid；
(2) sterilization fermentation liquid is added in diatomite, the weight ratio of diatomite and sterilization fermentation liquid is 1:100, then 70
It is filtered under the conditions of DEG C, finishes to obtain Sodium Hyaluronate.
(II) sewing product is prepared：
It is 50g Notogineng Extract, 200g EGF, 30g clindamycin, the 250g Sodium Hyaluronate of 800~850 mesh by granularity
With 450g conductivity be 0.05mS/m distilled water uniformly mix 30min under the revolving speed of 60r/min, obtain it is described it is rapid detumescence,
Sewing product that is antibacterial, repairing skin.
Embodiment 2
The present embodiment provides a kind of detumescences rapidly, the preparation method of sewing product that is antibacterial, repairing skin, including walk as follows
Suddenly：
(I) Sodium Hyaluronate is prepared, is included the following steps：
(1) streptococcus zooepidemicus kind fermentation liquid is cultivated, after hammer strain fermentating liquid is kept the temperature 1h under the conditions of 80 DEG C after the completion,
Add trichloroacetic acid be adjusted to system pH be 4.8, sterilize, after sterilization fermentation liquid；
(2) sterilization fermentation liquid is added in diatomite, the weight ratio of diatomite and sterilization fermentation liquid is 2:100, then 60
It is filtered under the conditions of DEG C, finishes to obtain Sodium Hyaluronate.
(II) sewing product is prepared：
It is 150g Notogineng Extract, 100g EGF, 70g clindamycin, the 150g hyaluronic acid of 950~1000 mesh by granularity
Sodium and 550g conductivity are that the distilled water of 0.08mS/m uniformly mixes 20min under the revolving speed of 80r/min, obtain and described disappear rapidly
Sewing product that is swollen, antibacterial, repairing skin.
Embodiment 3
The present embodiment provides a kind of detumescences rapidly, the preparation method of sewing product that is antibacterial, repairing skin, including walk as follows
Suddenly：
(I) Sodium Hyaluronate is prepared, is included the following steps：
(1) streptococcus zooepidemicus kind fermentation liquid is cultivated, hammer strain fermentating liquid is kept the temperature into 1.5h under the conditions of 75 DEG C after the completion
Afterwards, add trichloroacetic acid be adjusted to system pH be 4.6, sterilize, after sterilization fermentation liquid；
(2) sterilization fermentation liquid is added in diatomite, the weight ratio of diatomite and sterilization fermentation liquid is 1.5:100, then exist
It is filtered under the conditions of 65 DEG C, finishes to obtain Sodium Hyaluronate.
(II) sewing product is prepared：
It is 100g Notogineng Extract, 150g EGF, 50g clindamycin, the 200g hyaluronic acid of 850~950 mesh by granularity
Sodium and 500g conductivity are that the distilled water of 0.1mS/m uniformly mixes 25min under the revolving speed of 70r/min, obtain the rapid detumescence,
Sewing product that is antibacterial, repairing skin.
With reference to GB 27951-2011, rapid detumescence resulting to Examples 1 to 3, sewing product that is antibacterial, repairing skin
Performance rating is carried out, performance rating includes 5 aspects：Sensory properties, kills microbiological indicator, security requirement at physical and chemical index
And stability.
Evaluation sensory properties method be：The color and clarity of sewing product are checked with visual method.
The detection method of physical and chemical index is：The content of lead, mercury and arsenic in sewing product is detected respectively, and three's content is limited to
Lead < 40mg/L, mercury < 1mg/L, arsenic < 10mg/L.
Kill microbiological test method be：It presses《Disinfection technology standard》Method is measured.Microorganism is killed to refer to
Mark is as shown in table 1.
Table 1 kills microbiological indicator
Security requirement detection method is：It presses《Disinfection technology standard》Method is measured.Detection project is acute
Oral toxicity test, an intact skin irritant test, damaged skin irritant test, acute eye irritation test, skin metamorphosis examination
It tests and mutagenicity test.
Detection of Stability requirement：It is required that sewing shelf life of products is more than December.
It is as a result as follows after detecting：
Sensory properties testing result is：Detumescence, sewing product colour that is antibacterial, repairing skin rapidly obtained by Examples 1 to 3
It is transparent, clarify, be visible by naked eyes precipitating.
The testing result of physical and chemical index is：The results are shown in Table 2 for it.
Reduce swelling rapidly obtained by 2 Examples 1 to 3 of table, is antibacterial, the physical and chemical index result of the sewing product of reparation skin
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Lead/mg/L | 0.007 | 0.008 | 0.005 |
| Mercury/mg/L | It is not detected | It is not detected | It is not detected |
| Arsenic/mg/L | 0.004 | 0.006 | 0.002 |
Killing microorganism detection result is：The rapid sewing product reducing swelling, is antibacterial, repairing skin obtained by Examples 1 to 3
Killing microbiological indicator result is respectively as shown in table 3, table 4 and table 5.
The killing microbiological indicator result of the rapid sewing product reducing swelling, is antibacterial, repairing skin of 3 embodiment of table, 1 gained
The killing microbiological indicator result of the rapid sewing product reducing swelling, is antibacterial, repairing skin of 4 embodiment of table, 2 gained
The killing microbiological indicator result of the rapid sewing product reducing swelling, is antibacterial, repairing skin of 5 embodiment of table, 3 gained
Security requirement testing result is：The rapid sewing product reducing swelling, is antibacterial, repairing skin obtained by Examples 1 to 3
Security requirement testing result is as shown in table 6.
6 security requirement testing result of table
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Acute oral toxicity test | It is nontoxic | Low toxicity | It is nontoxic |
| Intact skin irritant test | Slight stimulation | It is non-stimulated | It is non-stimulated |
| Damaged skin irritant test | It is non-stimulated | It is non-stimulated | It is non-stimulated |
| Acute eye irritation test | It is non-stimulated | It is non-stimulated | It is non-stimulated |
| Skin metamorphosis test | It has no | It is extremely slight | It has no |
| Mutagenicity test | It is negative | It is negative | It is negative |
Detection of Stability result is：Rapid detumescence, sewing product that is antibacterial, repairing skin obtained by Examples 1 to 3 are guaranteed the quality
Phase is after measured more than December.
Conclusion (of pressure testing)：Reduce swelling rapidly obtained by Examples 1 to 3, is antibacterial, the sewing product of reparation skin is in sensory properties, reason
Change 5 index, killing microbiological indicator, security requirement and stability aspects to meet and be higher than national standard.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (9)
1. a kind of detumescence rapidly, sewing product that is antibacterial, repairing skin, which is characterized in that the raw material including following parts by weight：Three
Seven 5~15 parts of extracts, 10~20 parts of EGF, 3~7 parts of clindamycin, 15~25 parts of Sodium Hyaluronate and distilled water 45~55
Part.
2. rapid detumescence according to claim 1, sewing product that is antibacterial, repairing skin, which is characterized in that including as follows
The raw material of parts by weight：10 parts of Notogineng Extract, 15 parts of EGF, 5 parts of clindamycin, 20 parts of Sodium Hyaluronate and 50 parts of distilled water.
3. rapid detumescence according to claim 1 or 2, sewing product that is antibacterial, repairing skin, which is characterized in that described
Conductivity≤0.1mS/m of distilled water.
4. rapid detumescence according to claim 1 or 2, sewing product that is antibacterial, repairing skin, which is characterized in that described
Notogineng Extract granularity is 800~1000 mesh.
5. rapid detumescence according to claim 1 or 2, sewing product that is antibacterial, repairing skin, which is characterized in that described
The preparation method of Sodium Hyaluronate includes the following steps：
(1) streptococcus zooepidemicus kind fermentation liquid is cultivated, enzyme deactivation, sterilizing is successively carried out after the completion, obtains sterilization fermentation liquid；
(2) diatomite is added in sterilization fermentation liquid, Sodium Hyaluronate is obtained after filtering.
6. rapid detumescence according to claim 5, sewing product that is antibacterial, repairing skin, which is characterized in that step (1)
In, the mode of the enzyme deactivation is：Hammer strain fermentating liquid is kept the temperature into 1~2h under the conditions of 70~80 DEG C；The mode of the sterilizing
For：The fermentation liquid after enzyme deactivation is added in trichloroacetic acid, being adjusted to system pH is 4.5~4.8.
7. rapid detumescence according to claim 5, sewing product that is antibacterial, repairing skin, which is characterized in that step (2)
In, the weight ratio of the diatomite and sterilization fermentation liquid is 1~2：100；The temperature of the filtering is 60~70 DEG C.
8. the preparation method of any rapid detumescence of claim 1~7, sewing product that is antibacterial, repairing skin, feature
It is, each raw material is uniformly mixed.
9. the preparation method of rapid detumescence according to claim 8, sewing product that is antibacterial, repairing skin, feature exist
In, the mixed uniformly revolving speed be 60~80r/min, it is described it is uniform mix the time is 20~30min.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811086311.9A CN108852946A (en) | 2018-09-18 | 2018-09-18 | A kind of rapid detumescence, sewing product and preparation method thereof that is antibacterial, repairing skin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811086311.9A CN108852946A (en) | 2018-09-18 | 2018-09-18 | A kind of rapid detumescence, sewing product and preparation method thereof that is antibacterial, repairing skin |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103173507A (en) * | 2011-12-23 | 2013-06-26 | 宁波林叶生物科技有限公司 | Production technology for fermentatively producing sodium hyaluronate by utilizing bacterium |
| CN103705967A (en) * | 2013-12-19 | 2014-04-09 | 褚加冕 | Preparation method of sodium hyaluronate dressing |
| CN104873955A (en) * | 2015-06-30 | 2015-09-02 | 桂林华诺威基因药业有限公司 | Burn wound healing hydrogel |
| CN107213109A (en) * | 2017-05-19 | 2017-09-29 | 广州蜜妆生物科技有限公司 | A kind of anti-guarantor's elite of skin |
| CN107837209A (en) * | 2016-09-21 | 2018-03-27 | 张黎 | A kind of seamless cleaning fluid of sewing |
-
2018
- 2018-09-18 CN CN201811086311.9A patent/CN108852946A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103173507A (en) * | 2011-12-23 | 2013-06-26 | 宁波林叶生物科技有限公司 | Production technology for fermentatively producing sodium hyaluronate by utilizing bacterium |
| CN103705967A (en) * | 2013-12-19 | 2014-04-09 | 褚加冕 | Preparation method of sodium hyaluronate dressing |
| CN104873955A (en) * | 2015-06-30 | 2015-09-02 | 桂林华诺威基因药业有限公司 | Burn wound healing hydrogel |
| CN107837209A (en) * | 2016-09-21 | 2018-03-27 | 张黎 | A kind of seamless cleaning fluid of sewing |
| CN107213109A (en) * | 2017-05-19 | 2017-09-29 | 广州蜜妆生物科技有限公司 | A kind of anti-guarantor's elite of skin |
Non-Patent Citations (4)
| Title |
|---|
| 周映伽等: "表皮生长因子与恶性肿瘤相关性的研究进展", 《肿瘤基础与临床》 * |
| 国家药监局化妆品监管司: "《化妆品监督管理常见问题解答（一）》", 10 January 2019 * |
| 国家食品药品监督管理总局: "《化妆品安全技术规范》", 1 December 2016 * |
| 赵琼: "《微雕时代》", 28 February 2015 * |
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Application publication date: 20181123 |