CN108852855A - Biomimetic mineralization repairs desensitizer - Google Patents
Biomimetic mineralization repairs desensitizer Download PDFInfo
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- CN108852855A CN108852855A CN201810856471.0A CN201810856471A CN108852855A CN 108852855 A CN108852855 A CN 108852855A CN 201810856471 A CN201810856471 A CN 201810856471A CN 108852855 A CN108852855 A CN 108852855A
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- desensitizer
- repairs
- biomimetic mineralization
- dendrimer
- medical instrument
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/836—Glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/898—Polysaccharides
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- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Dental Preparations (AREA)
Abstract
The present invention provides a kind of biomimetic mineralizations to repair desensitizer and its application method, it is characterised in that：Including dendrimer 1-100000ppm, bioactivity glass 1-50%, tripotassium phosphate 0.1-20%, glycerol 1-5%, polyethylene glycol 30-70%, xanthan gum 0.5-8%, titanium dioxide 1-10%, essence 0.1-1%, saccharin sodium 0.1-2%, ethyl hydroxy benzoate 0.1-1%, laurel alcohol sulfuric ester 1-8%, wherein dendrimer includes with hydroxyl, carboxyl, phosphate radical or amino-terminated 0-5 polyamide-amine type dendrimer, the composition of bioactivity glass include (CaO)x(NaO2)y(SiO2)z(P2O5)1‑x‑y‑z, wherein x=0.25-0.45, y=0-1, z=0.34-0.64.The present invention also provides the application methods of the desensitizer, by desensitizer scrape can be uniformly distributed in the matched medical instrument of tooth, sting the 1min or more in mouth, wherein medical instrument includes visible foam tray on the market, thermoplasticity denture fixing device, tooth patch etc., and prove the dentine of desensitizer energy long-time depth closing exposure, to realize long-term desensitization, alleviate the effect of hyperesthesia of dentin.
Description
Technical field
Present invention relates particularly to a kind of biomimetic mineralizations for hyperesthesia of dentin's treatment to repair desensitizer and desensitizer
Application method
Background technique
Dentine hypersensitivity refers to that exposed dentine generates short and sharp pain to environmental stimuli, and cannot be attributed to
Defect of teeth caused by other specific reasons or lesion, typical stimulation include thermal stimulus, stimulation of blowing, mechanical irritation or
Chemical stimulation.When dentine exposure, when open tubules are unobstructed, environmental stimuli can cause small tube fluid to flow, dentine
Nerve fibre or nerve conduction medium inside and outside endochylema experience this stimulation, generate impulsion and upload, cause the feeling of pain.With
The cause of disease and pathogenesis of this dentine hypersensitivity are foundation, and a large amount of clinical practice and research have shown that, it is quick to reduce local nerve
Perception and/or the dentinal tubule for forming sediment covering (obstruction) exposure, the pharmaceutical preparation of isolation stimulation conduction or measure are equal
It can be used for treating dentine hypersensitivity.At present to the dentine hypersensitivity subject that symptoms are mild, usually selection desensitizer, such as anti-tooth sheet
Matter sensitivity toothpaste or gargle etc., however existing desensitizer is unable to satisfy ideal long-acting anti-hyperesthesia of dentin's treatment
Demand.
Summary of the invention
The demand of ideal long-acting anti-hyperesthesia of dentin's treatment, the present invention are unable to satisfy for existing desensitizer in the market
Provide a kind of desensitizer with the long-acting repair of deep layer based on biomimetic mineralization mechanism.
For this purpose, the present invention uses following technical scheme：Biomimetic mineralization repairs desensitizer, it is characterised in that：Described is bionical
It includes glycerol, polyethylene glycol, xanthan gum, titanium dioxide, essence, saccharin sodium, ethyl hydroxy benzoate, laruyl alcohol sulphur that mineralising, which repairs desensitizer,
Acid esters, tripotassium phosphate, bioactivity glass and dendrimer.Its specific quality accounting：Dendrimer 1-
100000ppm, bioactivity glass 1-50%, tripotassium phosphate 0.1-20%, glycerol 1-5%, polyethylene glycol 30-70%, xanthan
Glue 0.5-8%, titanium dioxide 1-10%, essence 0.1-1%, saccharin sodium 0.1-2%, ethyl hydroxy benzoate 0.1-1%, laruyl alcohol sulfuric acid
Ester 1-8%.
The dendrimer is polyamidoamine dendrimer.
It is further preferred that dendrimer is with hydroxyl, carboxyl, phosphate radical or amino-terminated 0-5 are for polyamide-
Amine type dendrimer.
Selected bioactivity glass is (CaO)x(NaO2)y(SiO2)z(P2O5)1-x-y-z, wherein x=0.25-0.45, y=
0-0.2, z=0.34-0.64.
It is further preferred that selected bioactivity glass ratio is (CaO)0.35(NaO2)0(SiO2)0.54(P2O5)0.11。
The present invention also provides the application methods that a kind of above-mentioned biomimetic mineralization repairs desensitizer, and steps are as follows：
(1) desensitizer adds water to not flow regime；
(2) desensitizer, which is added to, and to be uniformly distributed with the matched medical instrument of tooth；
(3) medical instrument is put into patient mouthful, patient is made to be engaged medical instrument 1min or more；
(4) medical instrument includes but is not limited to visible foam tray on the market, thermoplasticity denture fixing device, tooth patch etc..
The present invention can achieve following beneficial effect：
1, the present invention treats the desensitizer of dentine hypersensitivity, dendroid using the biomimetic mineralization performance of dendrimer
Macromolecule accounting 1-100000ppm, including with hydroxyl, carboxyl, phosphate radical or amino-terminated 0-5 polyamide-amine type branch
Shape macromolecule, and the dendrimer has template action, and fiber is in vitro or under vivo environment in inducible collagen
Mineralising.The distinguishing feature of the desensitizer can block dentinal tubule while being Rapid desensitization with depth, to reach long-acting de-
Quick effect.
2, the present invention is released effectively the ability of calcium, P elements using bioactivity glass under water environment, is hydroxy-apatite
The generation of stone provides raw material, and then induces the generation of dentin surface's hydroxyapatite, to realize that depth closes dentine
Tubule, the effect of long-acting treatment hyperesthesia of dentin.
3, the present invention has the medical instrument of matched well performance to act on effectively extension to the support load of desensitizer using with tooth
Action time at desensitizer and sufferer has given full play to the effect of desensitizer induction mineralising in situ.
Detailed description of the invention
Fig. 1 be in the embodiment of the present invention 4 through in deionized water or embodiment 1 biomimetic mineralization repair desensitizer processing after
4 weeks dentine of mineralising sample surfaces/section scanning electron microscope (SEM) photograph, wherein a is the table of control group (after deionized water is handled 4 weeks)
Surface scan electron microscope, b are the profile scanning electron microscope of control group, and c is experimental group (after biomimetic mineralization repairs desensitizer processing 4 weeks)
Surface scan electron microscope, d be experimental group profile scanning Electronic Speculum.
Fig. 2 is the biomimetic mineralization reparation desensitization in people's dentine and deionized water/embodiment 1 in the embodiment of the present invention 5
The surface microhardness data of mineralising 4 weeks dentine samples after agent is handled respectively.
Fig. 3 is that the biomimetic mineralization reparation desensitizer in deionized water/embodiment 1 in the embodiment of the present invention 6 is handled respectively
The permeability data of 4 weeks dentine of mineralising afterwards.
Specific embodiment
Embodiment 1
The present embodiment is related to the feasible formulation and its preparation process that biomimetic mineralization repairs desensitizer：
Dendrimer 1000ppm
Bioactivity glass 25%
Tripotassium phosphate 10%
Glycerol 2%
Polyethylene glycol 51%
Xanthan gum 3%
Titanium dioxide 5%
Essence 0.5%
Saccharin sodium 1%
Ethyl hydroxy benzoate 0.5%,
Laurel alcohol sulfuric ester 2%
Preparation process mainly includes the following steps：
(1) tripotassium phosphate and dendrimer are prepared by mixing into A liquid；
(2) by glycerol, polyethylene glycol, xanthan gum, titanium dioxide, essence, saccharin sodium, ethyl hydroxy benzoate, laurel alcohol sulfuric ester,
Bioactivity glass is prepared into B liquid；
(3) after mixing by A liquid and B liquid, it is dispensed into office preparation bottle, obtains biomimetic mineralization and repair desensitizer.
Embodiment 2
The present embodiment is related to the specifically used method that biomimetic mineralization repairs desensitizer, and medical instrument therein is with thermoplasticity tooth
For support, specific step is as follows:
(1) sticky white paste is obtained after desensitizer and a certain amount of water are agitated；
(2) whole biomimetic mineralizations is repaired desensitizer to be uniformly coated in thermoplasticity denture fixing device, is placed in subject mouthful,
And ensure at sensitivity of tooth be coated with desensitizer, enable subject be engaged at least 5min (if generating sense of discomfort when use, such as retch,
Saliva is excessive etc., and denture fixing device can take out to a moment and be reentered into again after alleviating).
(4) after being engaged, subject, which gargles, removes residue in mouth, while requiring subject after use in 1 hour
It must not brush teeth, diet.
Embodiment 3
The present embodiment is related to the reparation desensitizer of the biomimetic mineralization in embodiment 1 and tests the experiment of Effect of Dental Tubule Seal After
Card process.
Ethylenediamine tetra-acetic acid (EDTA) the acid etching demineralization of dentine sample, by sample in ultrasonic cleaning machine ultrasound 30min,
It is put into EDTA (pH=8.0) solution of the 0.5mol/L of 10mL and is taken out after 1min, rinse surface with PBS, again ultrasound 5min
It is stored in 4 DEG C of PBS solution.
After biomimetic mineralization in dentine sample deionized water or embodiment 1 is repaired desensitizer processing 30min,
Three times, then treated that dentine sample is individually placed in a PP centrifuge tube by each for rinsing in PBS solution, pours into 5mL
Saliva is simulated, is saved in 37 DEG C of constant temperature, simulation replacement saliva every day is primary, takes out the dentine sample of mineralising after 4 weeks, uses
Deionized water washing air-dries afterwards three times.Wherein, simulation salivarius formulation is CaCl20.1665g, KH2PO40.1224g, KCl
9.685g NaN30.065g, HEPES 4.766g adjust pH to 7.02 with 1mol/L KOH, are diluted to ultrapure water
1000mL。
Embodiment 4
The present embodiment is related in embodiment 3 surface of dentine sample/profile scanning Electronic Speculum before and after the processing as a result, such as attached drawing
Shown in 1a, b, for the dentine sample handled with deionized water, there was only a small amount of hydroxyapatite crystal in surface and tubule, and
There is a situation where dentinal tubule exposure, because dentin surface's collagenous fibres abundant can inhibit hydroxyapatite mine again
Change, a small amount of hydroxyapatite crystal of generation is also in that physical deposition effect generates, and non-induced mineralising forms, in addition, figure
1c, d show that the dentine sample surfaces for repairing desensitizer processing through biomimetic mineralization are covered by hydroxyapatite completely, and dentine is disconnected
Face figure shows that minerals can go deep into inside dentine, due to being full of neogenic mineral matter in dentinal tubule, is difficult to observe
To open dentinal tubule.This is because dendrimer can be effectively deep into dentinal tubule, it is hydroxyapatite
Good template effect is played in generation, in addition, bioactivity glass can be released effectively calcium, phosphonium ion under the action of water, is
The generation of oral cavity hydroxyapatite provides raw material, further enhances biomimetic mineralization and repairs desensitizer shape in dentine sample
At the effect of hydroxyapatite, to reach depth closing dentinal tubule, the effect of long-acting treatment.
Embodiment 5
The present embodiment is related to carrying out treated in embodiment 3 dentine sample surfaces the measurement of surface microhardness, measurement
Mode includes that plane sample is placed on MVK-H12 hardness tester, and with load 50g, the mode of pressure maintaining 15s measures the dimension of each sample
Family name's hardness.As shown in Fig. 2, being 52.15 ± 0.87HV and natural teeth sheet by the dentine sample surfaces hardness that desensitizer is handled
The hardness (53.14 ± 0.46HV) on matter surface is close, illustrates that biomimetic mineralization repairs the hydroxyapatite table of desensitizer inductive formation
Layer is similar to natural dentine minerals.
Embodiment 6
The present embodiment is related to treated in embodiment 3 dentine permeability determination, and specific measuring method is by tooth sheet
Respectively there is the circular rubber circle of a 4mm diameter to fix among matter sample two panels, and limits exposed dentine sample face with this
It is long-pending, the water column pressure of 100cm, and the capillary glass tube that horizontal positioned capacity is 15 μ L are provided in continuous mode, observed with this small
The movement of bubble, and the permeability of dentinal tubule is calculated by recording moving distance of the bubble within the unit time.Such as Fig. 3
Shown, biomimetic mineralization repairs desensitizer treated sample dentine permeability and is significantly lower than the dentine handled with deionized water
Sample, this proves that biomimetic mineralization repairs desensitizer and has good dentine plugging effect.
Embodiment 4,5,6 shows that biomimetic mineralization repairs desensitizer and has induction hydroxyapatite regeneration, depth mineralising tooth
Tubules and the effect for blocking dentinal tubule.
Claims (7)
1. biomimetic mineralization repairs desensitizer, it is characterised in that：It includes glycerol, poly- second two that the biomimetic mineralization, which repairs desensitizer,
Alcohol, xanthan gum, titanium dioxide, essence, saccharin sodium, ethyl hydroxy benzoate, laurel alcohol sulfuric ester, tripotassium phosphate, bioactivity glass and
Dendrimer.
2. biomimetic mineralization according to claim 1 repairs desensitizer, it is characterised in that：The biomimetic mineralization reparation desensitization
Agent includes that quality accounting is：Dendrimer 1-100000ppm, bioactivity glass 1-50%, tripotassium phosphate 0.1-20%,
Glycerol 1-5%, polyethylene glycol 30-70%, xanthan gum 0.5-8%, titanium dioxide 1-10%, essence 0.1-1%, saccharin sodium 0.1-
2%, ethyl hydroxy benzoate 0.1-1%, laurel alcohol sulfuric ester 1-8%.
3. biomimetic mineralization according to claim 2 repairs desensitizer, it is characterised in that：The dendrimer be with
Hydroxyl, carboxyl, phosphate radical or amino-terminated 0-5 polyamide-amine type dendrimer.
4. biomimetic mineralization according to claim 3 repairs desensitizer, it is characterised in that：The polyamidoamine branch
The template action that there are shape macromolecule induction minerals to generate.
5. biomimetic mineralization according to claim 1,2,3 or 4 repairs desensitizer, it is characterised in that：The bioactivity
Glass includes (CaO)x(NaO2)y(SiO2)z(P2O5)1-x-y-z, wherein x=0.25-0.45, y=0-1, z=0.34-0.64.
6. biomimetic mineralization according to claim 5 repairs desensitizer, which is characterized in that the bioactivity glass is one
Kind can gradually discharge the unorganic glass of calcium and phosphorus ions in water environment.
7. the application method that a kind of biomimetic mineralization repairs desensitizer, it is characterised in that：
(1) desensitizer scrape can be uniformly distributed in the matched medical instrument of tooth, sting the 1min or more in mouth；
(2) medical instrument can maintain desensitizer 1min or more in mouth；
(3) medical instrument includes but is not limited to that visible foam tray, thermoplasticity denture fixing device, tooth paste on the market.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810856471.0A CN108852855A (en) | 2018-07-31 | 2018-07-31 | Biomimetic mineralization repairs desensitizer |
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| CN201810856471.0A CN108852855A (en) | 2018-07-31 | 2018-07-31 | Biomimetic mineralization repairs desensitizer |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021020993A3 (en) * | 2019-07-18 | 2021-04-29 | Общество С Ограниченной Ответственностью "Сплат Глобал" | Use of dendrimers in agents for care of the teeth and oral cavity |
| CN113304055A (en) * | 2021-05-25 | 2021-08-27 | 陕西恒远生物科技有限公司 | Dentin desensitizing paste with bionic remineralization repairing effect and preparation process thereof |
| CN113749955A (en) * | 2021-09-28 | 2021-12-07 | 中南大学 | Preparation method of tooth gel, tooth paste and tooth gel with remineralization capability |
| CN114533611A (en) * | 2022-02-16 | 2022-05-27 | 重庆登康口腔护理用品股份有限公司 | Composition capable of enhancing dentin sensitivity resistance effect of bioactive material and preparation method and application thereof |
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| WO2021020993A3 (en) * | 2019-07-18 | 2021-04-29 | Общество С Ограниченной Ответственностью "Сплат Глобал" | Use of dendrimers in agents for care of the teeth and oral cavity |
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