CN108852477A - Filling prosthetic device for stem-cell therapy human articular cartilage defect - Google Patents
Filling prosthetic device for stem-cell therapy human articular cartilage defect Download PDFInfo
- Publication number
- CN108852477A CN108852477A CN201811060457.6A CN201811060457A CN108852477A CN 108852477 A CN108852477 A CN 108852477A CN 201811060457 A CN201811060457 A CN 201811060457A CN 108852477 A CN108852477 A CN 108852477A
- Authority
- CN
- China
- Prior art keywords
- articular cartilage
- human articular
- cover
- stem
- cartilage defect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3472—Trocars; Puncturing needles for bones, e.g. intraosseus injections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Abstract
The invention discloses a kind of filling prosthetic devices for stem-cell therapy human articular cartilage defect, including at least one depression generator, and the cover for being closed with human articular cartilage face paste, the cover it is top closed, make between the cover and human articular cartilage face formed positive pressure chamber；The cover is equipped with syringe interface, and the syringe for stem cell injection to be entered to the cartilage defect in human articular cartilage face is equipped in the syringe interface；The depression generator is connected to the pulp cavity of human articular cartilage sending down the fishbone, makes to form negative pressure in the pulp cavity of human articular cartilage sending down the fishbone.Its technical effect is that：Defective region, which is stripped off, in human articular cartilage by depression generator forms negative pressure, the stem cell injected from syringe can be made to flow to negative pressuren zone in this way, make the cartilage defect of stem cell filling human synovial, to be enriched in the region, the cartilaginous tissue that human articular cartilage strips off defective region is sufficiently repaired.
Description
Technical field
The present invention relates to a kind of filling reparations for stem-cell therapy human articular cartilage defect of medical instruments field
Device.
Background technique
The astragalus of kneed kneecap or ankle-joint is to be easiest to that cartilage damage and cartilage defect occurs in skeleton
Position.Cartilage damage occurs for kneecap and cartilage defect main cause is Patella Cartilage inflammation or Chondromalacia of patella.Astragalus occurs soft
The main reason for bone injury or cartilage defect is astragalus chondritis or astragalus focal necrosis.Above-mentioned illness disease incidence is high,
More satisfaction is low after, gently then causes the inconvenience of life, heavy then cause deformity.
The stem cell therapy for the treatment of cartilage defect is by micro fractures technology under arthroscope, in human articular cartilage at present
The stem cell injection hole of a connection cartilage defect is drilled out in the cortex bone on face surface, syringe passes through stem cell injection
Hole injects stem cell to cartilage defect, then the differentiation of stem cells chondroblast in local microenvironment, completes people
The reparation of cartilage in body joint.
The shortcomings that stem cell therapy for the treatment of cartilage defect, is at present：Cartilage defect in articular cartilage face, form
It is often considerably complicated.The complicated form of cartilage defect causes the stem cell of injection cartilage defect that can not fill completely entire cartilage
Defect needs patient to carry out further treatment reparation surplus so that cartilage defect be caused to be unable to get complete correction
Remaining cartilage defect brings new pain and unnecessary cost to patient.
Summary of the invention
It is a kind of soft for stem-cell therapy human synovial the purpose of the invention is to overcome the deficiencies of the prior art and provide
The filling prosthetic device of bone defect, stem cell can be made, which completely to fill, has complicated form in human articular cartilage face
Cartilage defect.
Realizing a kind of technical solution of above-mentioned purpose is：A kind of filling for stem-cell therapy human articular cartilage defect
Prosthetic device, the cover including at least one negative pressure device and for being closed with human articular cartilage face paste, the top of the cover
Closing makes to form positive pressure chamber between the cover and human articular cartilage face；
The cover is equipped with syringe interface, is equipped in the syringe interface and closes for stem cell injection to be entered human body
Save the syringe of the cartilage defect of cartilage surface；
The negative pressure device is connected to the pulp cavity of human articular cartilage sending down the fishbone, makes shape in the pulp cavity of human articular cartilage sending down the fishbone
At negative pressure.
Further, the inner periphery of the cover lower part is equipped with the silicon for the annular that one can close with human articular cartilage face paste
Rubber mat.
Further, the inner periphery of the cover lower part is equipped with the gas for the annular that one can close with human articular cartilage face paste
Capsule pad, the air bag cushion are equipped with balloon occlusion device.
Further, the syringe interface is located at the top of the cover.
Further, the negative pressure device bores the pulp cavity for being connected to human articular cartilage sending down the fishbone by hollow lead.
Further, the bottom of the cover is equipped with the hollow of adjustable position and leads drill bushing interface tube, described hollow to lead
Be drilled through it is described it is hollow lead drill bushing interface tube, be connected to the pulp cavity of articular cartilage sending down the fishbone, the depression generator pass through the sky
The heart leads the pulp cavity for boring connection human articular cartilage sending down the fishbone.
Further, between the side wall and roof of the cover be equipped with size adjustment mechanism.
Further, the size adjustment mechanism is between the side wall of the cover and the roof of the cover
The first end of extroversion section, the export-oriented section connects the roof of the cover, and the second end of the universal joint connects the cover
The side wall of body.
Further, the quantity of the negative pressure device is one or two.
Further, the depression generator is negative pressure pump or negative suction pipe.
Using a kind of technology of filling prosthetic device for stem-cell therapy human articular cartilage defect of the invention
Scheme, including at least one negative pressure device, and the cover for being closed with human articular cartilage face paste, the top envelope of the cover
It closes, makes to form positive pressure chamber between the cover and human articular cartilage face；The cover is equipped with syringe interface, the injection
The syringe for stem cell injection to be entered to the cartilage defect in human articular cartilage face is equipped in device interface；The negative pressure dress
It sets and is connected to the pulp cavity of human articular cartilage sending down the fishbone, make to form negative pressure in the pulp cavity of human articular cartilage sending down the fishbone.Its technical effect
It is：Defective region is stripped off in human articular cartilage, the pulp cavity of subchondral bone is connected to by the micro fractures drilling to subchondral bone and bears
Pressure device, the cartilage that the stem cell injected from syringe can be made to flow to negative pressuren zone in this way strip off defective region, make marrow stem
The cartilage of cell filling human synovial strips off defective region, to sufficiently repair the cartilage group that human articular cartilage strips off defective region
It knits.
Detailed description of the invention
Fig. 1 is a kind of filling prosthetic device embodiment 1 for stem-cell therapy human articular cartilage defect of the invention
Schematic front view.
Fig. 2 is a kind of filling prosthetic device embodiment 1 for stem-cell therapy human articular cartilage defect of the invention
Schematic top plan view.
Fig. 3 is a kind of filling prosthetic device embodiment 2 for stem-cell therapy human articular cartilage defect of the invention
Schematic front view.
Fig. 4 is a kind of filling prosthetic device embodiment 2 for stem-cell therapy human articular cartilage defect of the invention
Schematic top plan view.
Specific embodiment
The present inventor is referring to FIG. 1 to FIG. 4, in order to preferably understand technical solution of the present invention,
Below by specifically embodiment, and will be described in detail with reference to the accompanying drawings：
Embodiment 1
One of the present embodiment is used for the filling prosthetic device of stem-cell therapy human articular cartilage defect, is used for kneecap
The reparation of 8 cartilage defect, including cover 1, cover 1 can be bonded with the cartilage surface of kneecap 8, cover 1 it is top closed, make cover
Positive pressure chamber 10 is formed between 1 and the cartilage surface of kneecap 8.
The top of cover 1 is equipped at least one syringe interface 13, is equipped with one in each syringe interface 13 and is used for
Stem cell is injected into the syringe 2 of the cartilage defect of the cartilage surface of kneecap 8.The syringe needle of syringe 2 enters kneecap 8
Cartilage defect, to the cartilage defect of kneecap 8 inject stem cell.
In order to guarantee the positive pressure in cover 1, internal perisporium around 1 lower part of cover is equipped with a ring shape elastic cushion 14, annular
Elastic cushion 14 can be the air bag cushion of solid silicagel pad or inflatable.Balloon occlusion dress is typically provided on inflatable airbag pad
Set 141.
Cyclic spring pad 14 can be bonded with the cartilage surface of kneecap 8, make to form closed positive pressure chamber between cover 1 and kneecap 8
10。
One of the present embodiment for stem-cell therapy human articular cartilage defect filling prosthetic device be additionally provided with to
A few depression generator 3.Depression generator 3 can be negative pressure pump.
Preferably, it by arthroscope, using micro fractures technology, digs in the cortex bone on the surface of kneecap 8 and is sent out with negative pressure
3 quantity of generating apparatus is identical, runs through cortex bone, to expose the negative inspiratory pressure hole of the pulp cavity of the subchondral bone of kneecap 8.Negative pressure hair
The quantity of generating apparatus 3 is one or two.Each depression generator 3, through corresponding negative inspiratory pressure hole, protrudes into kneecap by one
The hollow of the pulp cavity of the subchondral bone of bone 8 leads the pulp cavity for boring the subchondral bone of 31 connection kneecaps 8.
Hollow brill 31 of leading both can be independently of cover 1, the directly pulp cavity of the subchondral bone of connection kneecap 8, can also be in cover
The hollow of bottom setting adjustable position of body leads drill bushing interface tube, it is hollow lead brill 31 through it is described it is hollow lead drill bushing interface tube, with
The pulp cavity of the subchondral bone of kneecap 8 is connected to, and depression generator 3 bores 31 pulp cavitys for being connected to Patella Cartilage sending down the fishbones by hollow lead,
Make to generate negative pressure in the pulp cavity of Patella Cartilage sending down the fishbone.
Hollow lead bores the lower section that interface is located at cyclic spring pad 14.Lead brill 31 when not used hollow, it is hollow lead brill 31 can be straight
It connects from hollow lead and is screwed down on brill interface.
Since the pulp cavity of kneecap 8 has fine and close porous structure, and connected by the porous structure and cartilage defect
It is logical, after depression generator 3 is opened, the common work of the cartilage defect of kneecap 8 in depression generator 3 and the porous structure
With lower formation negative pressure.Pressure difference is formed between positive pressure chamber 10 and the cartilage defect of kneecap 8, under the action of pressure difference, marrow stem
Cell is full of the cartilage defect of kneecap 8.
The filling prosthetic device of stem-cell therapy human articular cartilage defect is used for using one of the present embodiment, i.e.,
Keep the form of the cartilage defect of kneecap 8 complicated again, in the effect of positive pressure chamber 10 and the cartilage defect pressure difference of kneecap 8
Under, stem cell can also be made to be full of the cartilage defect of entire kneecap 8, so that 8 cartilage defect of kneecap be made to obtain
Complete correction reduces the cost and pain of patient.
Embodiment 2
One of the present embodiment is used for the filling prosthetic device of stem-cell therapy human articular cartilage defect, is used for human body
The reparation of the cartilage defect of the astragalus 9 of ankle-joint, including cover 1, cover 1 include the side wall 11 that can be bonded with 9 cartilage surface of astragalus,
And side wall 11 is top closed, make the roof 12 that positive pressure chamber 10 is formed between cover 1 and the cartilage surface of astragalus 9.
The side wall 11 of cover 1 is equipped with a syringe interface 13, is equipped with one in syringe interface 13 and is used for marrow
Stem cell injection enters the syringe 2 of the cartilage defect of astragalus 9.
In order to guarantee the positive pressure in cover 1, around being equipped with several size adjustment mechanisms 16 between side wall 11 and roof 12, with
Side wall 11 and the cartilage surface of astragalus 9 is set to fit closely.In the present embodiment, size adjustment mechanism 16 is that can make side wall 11 and roof
The export-oriented of Relative sliding occurs between 12 to save, the roof 12 of the first end connection cover 1 of the export-oriented section, the universal joint
The second end connects the side wall 11 of cover 1, and universal joint can be used for the precise positioning for lower section cartilage defect lesion, is convenient for pulp cavity
The foundation of negative pressuren zone.
One of the present embodiment is used for the filling prosthetic device of the thin-skinned bone defect of stem-cell therapy human articular cartilage also
Equipped at least one depression generator 3.Depression generator 3 is negative suction pipe.
Preferably, it by arthroscope, using micro fractures technology, digs in the cortex bone on the surface of astragalus 9 and is sent out with negative pressure
3 quantity of generating apparatus is identical, runs through cortex bone, to expose the negative inspiratory pressure hole of the pulp cavity of the subchondral bone of astragalus 9.Negative pressure hair
The quantity of generating apparatus 3 is one or two.Each depression generator 3 by one through corresponding negative inspiratory pressure hole, protrude into away from
The hollow of the pulp cavity of bone 9 leads the pulp cavity for boring the subchondral bone of 31 connection astragalus 9.
Hollow brill 31 of leading can also both pass through independently of cover 1, the directly pulp cavity of the subchondral bone of connection astragalus 9
The adjustable hollow pulp cavity led drill bushing interface tube 15 and be connected to the subchondral bone of astragalus 9 in position on cover 1.Brill is led hollow
31 when not used, and hollow brill of leading can be screwed down directly on drill bushing interface tube 15 from hollow lead.
Since the pulp cavity of the subchondral bone of astragalus 9 has fine and close porous structure, and pass through the porous structure and cartilage
Defect connection, after depression generator 3 is opened, the cartilage defect of astragalus 9 is in depression generator 3 and the porous knot
Negative pressure is formed under the collective effect of structure.Pressure difference is formed between positive pressure chamber 10 and the cartilage defect of astragalus 9, in the effect of pressure difference
Under, stem cell is full of the cartilage defect of astragalus 9.
The filling reparation of the thin-skinned bone defect of stem-cell therapy human articular cartilage is used for using one of the present embodiment
Device, even if the form of the cartilage defect of astragalus 9 is complicated again, in the cartilage defect pressure difference of positive pressure chamber 10 and astragalus 9
Under the action of, stem cell can also be made to be full of the cartilage defect of entire astragalus 9, to make the cartilage defect of astragalus 9
Position obtains complete correction, reduces the cost and pain of patient.
A kind of filling prosthetic device for the thin-skinned bone defect of stem-cell therapy human articular cartilage of the invention, not only may be used
Reparation for kneed kneecap 8, the astragalus 9 of ankle-joint can be also used for the reparation of other articular cartilage faces such as carpal bone.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention,
And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above
Change, modification will all be fallen within the scope of claims of the present invention.
Claims (10)
1. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect, including it is used for and human articular cartilage
Face paste close cover, the cover it is top closed, make between the cover and human articular cartilage face formed positive pressure chamber；It is special
Sign is：
The cover is equipped with syringe interface, is equipped in the syringe interface soft for stem cell injection to be entered human synovial
The syringe of the cartilage defect in bone face；
It further includes at least one depression generator, the pulp cavity company of the depression generator and human articular cartilage sending down the fishbone
It is logical, make to form negative pressure in the pulp cavity of human articular cartilage sending down the fishbone.
2. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 1,
It is characterized in that：The inner periphery of the cover lower part is equipped with the silicagel pad for the annular that one can close with human articular cartilage face paste.
3. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 1,
It is characterized in that：The inner periphery of the cover lower part is equipped with the air bag cushion for the annular that one can close with human articular cartilage face paste, institute
Air bag cushion is stated equipped with balloon occlusion device.
4. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 1,
It is characterized in that：The syringe interface is located at the top of the cover.
5. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 1,
It is characterized in that：The depression generator bores the pulp cavity for being connected to human articular cartilage sending down the fishbone by hollow lead.
6. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 5,
It is characterized in that：The bottom of the cover is equipped with the hollow of adjustable position and leads drill bushing interface tube, and hollow lead is drilled through the sky
The heart leads drill bushing interface tube, is connected to the pulp cavity of articular cartilage sending down the fishbone, and the depression generator is connected to by the hollow brill of leading
The pulp cavity of human articular cartilage sending down the fishbone.
7. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 1,
It is characterized in that：Size adjustment mechanism is equipped between the side wall and roof of the cover.
8. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 7,
It is characterized in that：The size adjustment mechanism is the export-oriented section between the side wall of the cover and the roof of the cover, institute
The first end for stating export-oriented section connects the roof of the cover, and the second end of the universal joint connects the side wall of the cover.
9. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 8,
It is characterized in that：The quantity of the depression generator is one or two.
10. a kind of filling prosthetic device for stem-cell therapy human articular cartilage defect according to claim 1,
It is characterized in that：The depression generator is negative pressure pump or negative suction pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811060457.6A CN108852477A (en) | 2018-09-12 | 2018-09-12 | Filling prosthetic device for stem-cell therapy human articular cartilage defect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811060457.6A CN108852477A (en) | 2018-09-12 | 2018-09-12 | Filling prosthetic device for stem-cell therapy human articular cartilage defect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108852477A true CN108852477A (en) | 2018-11-23 |
Family
ID=64323720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811060457.6A Pending CN108852477A (en) | 2018-09-12 | 2018-09-12 | Filling prosthetic device for stem-cell therapy human articular cartilage defect |
Country Status (1)
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| CN (1) | CN108852477A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109363762A (en) * | 2018-12-18 | 2019-02-22 | 艾科美医疗器械（深圳）有限公司 | A kind of negative pressure suction type bone cement device for casting and method for filling |
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| US20080269674A1 (en) * | 2007-04-25 | 2008-10-30 | Biomet Sports Medicine, Inc. | Localized Cartilage Defect Therapy |
| CN101686894A (en) * | 2007-06-29 | 2010-03-31 | 凯希特许有限公司 | Activation of bone and cartilage formation |
| CN203494006U (en) * | 2013-09-16 | 2014-03-26 | 王影 | Stem cell negative pressure syringe |
| CN103732268A (en) * | 2011-08-03 | 2014-04-16 | 凯希特许有限公司 | Reduced-pressure wound dressings |
| CN103857352A (en) * | 2011-10-13 | 2014-06-11 | 凯希特许有限公司 | Stimulation of cartilage repair using reduced pressure treatment |
| CN209203455U (en) * | 2018-09-12 | 2019-08-06 | 上海交通大学医学院附属第九人民医院 | Filling prosthetic device for stem-cell therapy human articular cartilage defect |
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2018
- 2018-09-12 CN CN201811060457.6A patent/CN108852477A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1323228A (en) * | 1998-08-14 | 2001-11-21 | 维里根国际移植服务(Vtsi)股份公司 | Methods instruments and materials for chondrocyte cell transplantation |
| US20080269674A1 (en) * | 2007-04-25 | 2008-10-30 | Biomet Sports Medicine, Inc. | Localized Cartilage Defect Therapy |
| CN101686894A (en) * | 2007-06-29 | 2010-03-31 | 凯希特许有限公司 | Activation of bone and cartilage formation |
| CN103732268A (en) * | 2011-08-03 | 2014-04-16 | 凯希特许有限公司 | Reduced-pressure wound dressings |
| CN103857352A (en) * | 2011-10-13 | 2014-06-11 | 凯希特许有限公司 | Stimulation of cartilage repair using reduced pressure treatment |
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| CN209203455U (en) * | 2018-09-12 | 2019-08-06 | 上海交通大学医学院附属第九人民医院 | Filling prosthetic device for stem-cell therapy human articular cartilage defect |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109363762A (en) * | 2018-12-18 | 2019-02-22 | 艾科美医疗器械（深圳）有限公司 | A kind of negative pressure suction type bone cement device for casting and method for filling |
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