CN108850440A - A kind of bifidobacterium longum feed addictive - Google Patents
A kind of bifidobacterium longum feed addictive Download PDFInfo
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- CN108850440A CN108850440A CN201810511803.1A CN201810511803A CN108850440A CN 108850440 A CN108850440 A CN 108850440A CN 201810511803 A CN201810511803 A CN 201810511803A CN 108850440 A CN108850440 A CN 108850440A
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- freeze
- dried powder
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- bifidobacterium longum
- sea
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A kind of bifidobacterium longum feed addictive of the present invention, it is characterized in that being uniformly mixed by bifidobacterium longum, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder, the fermentation egg-shell meal for adding surplus again is uniformly mixed, and composite packaging is made:Bifidobacterium longum 10000 hundred million -120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 5-50g, Rosa roxburghii freeze-dried powder 5-50g, wintercherry freeze-dried powder 3-30g, blackcurrant freeze-dried powder 3-30g, cactus freeze-dried powder 50-150g, remaining is fermentation egg-shell meal.The present invention is single type bifidobacterium longum feed addictive, and clear containing viable count, has specific application and Quantitatively Selecting conducive to user.The present invention is using sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus freeze-dried powder and fermentation egg-shell meal as the matrix of additive, not only improve the nutritive value of bifidobacterium longum additive, promote the metabolism of animal simultaneously, improve the disease resistance of body, promote growth of animal, finally improves the economic benefit of its aquaculture.
Description
Technical field
The invention belongs to feed additive fields, are related to a kind of Bifidobacterium feed addictive for cultivated animals.Tool
Body is related to a kind of bifidobacterium longum feed addictive.
Background technique
Bifidobacterium was separated in 1899 by Tissier for the first time, was a kind of Grain-positive bacillus.The bifid bar being currently known
There is more than 30 kind in Pseudomonas.It is compared with lactic acid bacteria, Bifidobacterium has the following disadvantages:(1)Nutritional ingredient is required strictly and multiple
It is miscellaneous, it must could be grown containing auxin or yeast extract in culture medium;(2)Anaerobic condition is more stringent;(3)In the low environment of pH
The lower time-to-live is short.Bifidobacterium can make carbohydrate fermentation, generate a large amount of acetic acid and lactic acid, to inhibit to have potential pathogenic
Enterobacteria etc. growth and breeding, progressively reach the balance of enteric microorganism bacterium.When animal feeding environment, feed, disease, abuse
The reasons such as antibiotic and reduce bifidobacteria, when intestinal flora being caused to lack of proper care, pathogenic bacteria will take advantage of a weak point, great Liang Fan
It grows, secretes endotoxin, cause disease finally, by taking Bifidobacterium living, so that it settled down, bred in enteron aisle, can promote
It is balanced into maintenance intestinal microecology, achievees the purpose that treatment, health care.Its Bifidobacterium of document report disclosed in the country at present
Pharmacological action is as follows:1. Bifidobacterium can be made to be colonized in intestinal mucosa rapidly, and microorganism is formed in conjunction with intestinal epithelial cell
Film prevents the field planting and invasion of pathogenic bacteria;A large amount of lactic acid and acetic acid are generated, improves enteral environment, maintains normal enterocinesia,
Pathogenic bacteria are promoted to excrete;Directly inhibition or antagonism shigella dysenteriae, typhoid bacillus, Pseudomonas aeruginosa, enteropathogenic E. Coli, Portugal
The growth of the pathogenic bacteria such as grape coccus.2. removing the poisonous and harmful metabolite that pathogenic bacteria are discharged, endotoxin source is reduced;Inhibit
Pathogenic flora growth, reduces level of endotoxin in blood, adjusts microecological balance, prevents and treats endotoxemia.3. a variety of dimensions can be synthesized
Raw element(Such as vitamin B1, B2, B6, B12, niacin, folic acid)And biological enzyme;It is acidified enteron aisle, is conducive to iron, calcium and vitamin
The absorption of D prevents the generation of hypoferric anemia and vitamin D deficiency;A variety of amino acid and microelement can be supplemented.4. can swash
The phagocytic activity of body phagocyte living, enhances the anti pathologic immunity function of body.Carcinogen is removed, reduces to test and move 5. having
The effect of the tumor incidence of object.6. free radical and lipid peroxide can be removed, delay the aging of cell;Reduce harmful substance
Source promotes the ammonia in blood to shift and be discharged to enteral, mitigates the injured possibilities of vitals such as the heart, liver, kidney, delay it
Ageing process.It can be used for the treatment of indigestion, constipation, enteritis, diarrhea etc.;Intestine dysbacteriosis caused by a variety of causes and thus
The prevention and treatment of caused a variety of diseases such as suprainfection, autogenous infection etc..
Bifidobacterium longum is that Minister Agriculture of China announces No. 2045 announcement《Feed addictive catalogue(2013)》Allow to use
There are aqua and pulvis two major classes with regard to the dosage form that current bifidobacterium longum is used as additive in the microbial bacteria of cultivated animals,
Its aqueous solution dosage form is because the nutritional substance in thallus aqua easy to use continues to be metabolized, growth fermentation, therefore, this dosage form
Thallus plays pendulum, and storage life is shorter.Powder formulation is then that the thallus lived is utilized the dry hand such as low temperature hot wind, freezing
Section, thallus or gemma are dehydrated at a slow speed, and thallus is made to be in stable drying dormant state, recycle substance that can be feeding
It is uniformly mixed as filler and relatively stable powder-type biological feed additive is made.But current manufacturing enterprise is considered
Raw material be easy to get and processing cost, often select rice bran, wheat bran, corn flour, maize cob meal, peanut shell powder, conch meal, vermiculite
One or more of powder, mountain flour, calcium carbonate, medical stone, zeolite powder mixture, some are also made using plant straw powder or grass meal
For filler material.The considerations of these are in line with production cost then has ignored the stability of microbial bacteria and the trophism of feed addictive
Value.
In order in use, have certain adhesion, microbial bacteria feed addictive be made to exist in microbial bacteria additive
It admixes when being mixed in animal feed, can be adsorbed on animal feed, convenient for the uniformity in animal feeding and be fed into bacterium amount
Maximization, some products take pains a certain amount of binder of addition.
In order to make to raise the relative constant of animal stomach inner pH value, acid is continued up to after so that the foodstuff being fed into is entered small intestine
The effect of change, in the product often simultaneously using acidulants such as citric acid, lactic acid, hydrochloric acid, fumaric acid, but these acidulants are not only straight
It connects and locally causes acidity too strong microbial bacteria contained by additive, influence the survival of thallus, meanwhile, these acidifying substances are to cultivation
Animal also without the nutritive value directly utilized, meanwhile, there is very big irritation to the gastrointestinal tract of the cubs of livestock and poultry, young fowl,
Compatibility is using not ideal enough.
Above-mentioned deficiency can be overcome by developing one kind, can either keep stability, the trophism of institute's mycetome, be had again to thallus
There is adhesion, while having again to the filler used and providing the additive for microbe feedstuff of nutritive value to cultivated animals, is
Promote the basis of feed additive industry long-term stability development.
Summary of the invention
The purpose of the present invention is to provide a kind of new single type bifidobacterium longum feed addictive, which is raised
Not only there is feed additives thallus to stablize, and the thallus time-to-live is long, and used auxiliary agents have certain adhesiveness
And adsorptivity, thallus can be made preferably to be bonding on one with auxiliary agents, meanwhile, complementary additive has certain acid
Property can not only provide nutriment abundant after animal feeding, while to be able to maintain stomach inner pH value relatively permanent for its acidic materials
It is fixed, into small intestine after the effect of continuing up to acidification.The purpose is to provide the long bifid bar of a kind of more stability and trophism
Bacterium feed addictive.The Ministry of Agriculture of bifidobacterium longum China announces No. 2046《Feed addictive catalogue(2013)》Announcing allows
The microorganism used.And Food and Drug Administration and feed management association are considered safe microorganism fodder, therefore
The development and application of bifidobacterium longum feed addictive are safe.
A kind of bifidobacterium longum feed addictive of the present invention, it is characterized in that by bifidobacterium longum and a certain amount of seabuckthorn fruit powder,
Ribes burejense powder, wintercherry powder, blackcurrant powder, cactus powder and fermentation egg-shell meal uniformly mix, and obtain a kind of new bifidobacterium longum feeding
The thallus of feed additives, this additive is stablized, and the thallus time-to-live is long, and seabuckthorn fruit powder, Ribes burejense powder, wintercherry powder, blackcurrant powder
Sugar content is high, and especially cactus powder all has preferable Adhesion property, and fermentation egg-shell meal also has preferable adsorptivity.Wherein
Sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant are the ascorbic fruits of high-content, not only provide vitamin abundant etc. to cultivated animals
Nutriment, the acidic materials after feeding in fruit powder play the effect for promoting digestion well, to highlight the present invention
Purpose.
In order to realize the present invention, the following technical solutions are specifically adopted:
A kind of bifidobacterium longum feed addictive, feature it be first by bifidobacterium longum, sea-buckthorn freeze-dried powder, Rosa roxburghii Tratt be lyophilized
Powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then add the fermentation egg-shell meal mixing of surplus
Even, composite packaging is made:Bifidobacterium longum 10000 hundred million -120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-drying
Powder 5-50g, Rosa roxburghii freeze-dried powder 5-50g, wintercherry freeze-dried powder 3-30g, blackcurrant freeze-dried powder 3-30g, cactus freeze-dried powder 50-
150g, remaining is fermentation egg-shell meal.
Bifidobacterium longum described above is bifidobacterium longum dry powder product.
The bifidobacterium longum dry powder product, can be used it is commercially available be used as every gram of feed addictive it is dense containing viable bacteria
The weight proportion of the preparation that degree is no less than 200 hundred million, the bifidobacterium longum dry powder product and the filler material in formula is by bacterium
The thallus content of soma powder and final products determines.
The bifidobacterium longum dry powder product also can use the culture medium that existing method selection accordingly optimizes and pass through liquid
Then body Zymolysis Equipment culture is separated the thallus in fermentation liquid with high speed centrifugation mode, be placed in dry indoor cold wind
Or bacterium mud drying is made with vacuum freeze drying mode, every gram of viable bacteria concentration no less than 200 hundred million thallus of acquisition are dry
Powder product.
Sea-buckthorn freeze-dried powder described above, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder,
It being made by following methods, technical process is that fresh sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus is taken to remove carpopodium respectively,
The impurity such as rotten fruit, rinsing, freezing, lyophilization, low-temperature grinding are not removed the peel, deseeding step;Rinsing condition described above is
With the citric acid of 40 DEG C of water addition weight 0.1%, 15min is rinsed, and be stirred continuously, pulls out to be put into pure water and rinse 3 times;On
Stating freezing is that will be cooled to rapidly -45 DEG C or less after sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus sabot respectively;Above-mentioned distillation
Dry process conditions are temperature-22-- 32 DEG C, and vacuum degree 120-150Pa is dry until moisture is less than 6%/w;It is above-mentioned
Low-temperature grinding is the crushing that temperature of charge is in 0 DEG C or less progress, 100 mesh of grinding particle size >.
Composite packaging described above uses interior outer bag composite packaging, and inner bag uses polypropylene plastics pocket, and outer packing uses aluminium
Foil bag is filled with silica-gel desiccant pouch between interior outer bag.
Fermentation egg-shell meal described above, is to clean up eggshell, dries moisture, in advance drying process 1-2 hours, so
After be ground into 40-50 mesh powder, suitable water, which is added, makes into water content in 45-55%/w, adds the ferment of egg-shell meal weight 20%
Female bacterium is mixed thoroughly, is fermented 60-72 hours under the conditions of temperature is 31 DEG C -33 DEG C, after fermentation, fermentation materials is adjusted to temperature
Carbonyl ammonia is carried out under the conditions of being 80-90% for 82-92 DEG C, humidity(Also referred to as Maillard reaction)Reaction 22-28 days, then, by material
Moisture content < 5%/w is dried under the conditions of being not more than 100 DEG C using electric baking case, is crushed, is sieved with 100 mesh sieve to obtain the final product.
Drying described above uses heated-air drying or far-infrared ray drying;Dry condition is 180 DEG C -300 DEG C, drying
Purpose kill the harmful substances such as microorganism and helminth first is that reaching, second is that the crisp matterization of eggshell can be made to be conducive to crush, and make powder
Egg-shell meal after broken is loose conducive to fermentation.
The carbonyl ammonia reaction, i.e. Maillard reaction, also known as " non enzymatic browning reacton ", are carbonyls(Reduced sugar
Class)And amino-compound(Amino acid and protein)Between reaction.
The above-mentioned purpose that eggshell coarse powder is used to saccharomycetes to make fermentation, first is that can effectively make eggshell sufficiently soft using fermentation process
Change, the egg-shell meal after making fermentation is loose, is easy to mix with unclassified stores;Second is that can effectively be made in eggshell using saccharomycetes to make fermentation
The ingredients such as calcium obtain effective bioconversion, form BIOLOGICAL CALCIUM, conducive to being absorbed and utilized for animal, saccharomycetes to make fermentation can make fermentation material
Material forms the mass propagation of more protein, especially saccharomycete, and it is peculiar to increase yeast institute for the aggregation for the ingredient that can have additional nutrients
The multiple nutritional components such as glucose, protein, nucleic acid, vitamin, carbohydrate, lipid-like substances, especially B race dimension life
Element such as B1、B2、B6、B12And the physiological activators such as folic acid, niacin, pantothenic acid, inositol get a promotion, these beneficial nutrients
Matter ingredient undoubtedly plays the nutritional ingredient for improving product of the present invention, improves its nutritive validity.
The further carbonyl ammonia of egg-shell meal is reacted in the present invention, first is that promoting the maturing process of eggshell, is further made wherein
Calcareous ingredient obtain sufficient bioconversion, biological calcium component is formed, second is that obtaining the protein component in material sufficiently
Bioconversion, amino acid is degraded to, third is that a large amount of aminoacid ingredients to be formed is made to be converted into the small molecules object such as small peptide and small peptide
Matter, conducive to digesting and absorbing after animal feeding, the reaction of carbonyl ammonia not only promotes the trophic function of product, after the reaction of carbonyl ammonia
Material can further increase the application that gas porosity is conducive to mix feed, while carbohydrate being made to be converted into reduced sugar, produce simultaneously
Raw fragrance matter abundant, not only improves the anti-immunity ability of product, further improves the flavor of product, increase being fond of for animal
Property.
Eggshell described above is the mixed of any one or a few in egg shell, Ovum Anas domestica putamina, goose egg-shell and quail eggshell
Close eggshell.
Saccharomycete described above(saccharomyces)For candida utili(Candida utilis), the torrid zone it is false
Silk yeast(Candida tropicalis), brewer's yeast(Saccharomyces cerevisiae), brewer's yeast
(Saccharomyces cerevisiae)And fodder yeast(Candida Tropicali)In any one.
Above-mentioned saccharomycete can choose using all viable bacterias as food additives or feed addictive commercially available
Concentration is no less than 200 every gram hundred million thalli dry powder products.
Existing method preparation can also be used in above-mentioned saccharomycete, such as can accordingly be optimized according to the selection of the property of strain
Then thallus in fermentation liquid is separated with high speed centrifugation mode, is set by the culture of Liquid Culture Zymolysis Equipment by culture medium
Bacterium mud drying is made in the indoor cold air drying of drying or with freeze-drying mode, obtaining viable bacteria concentration respectively is every gram
200 hundred million thalli dry powder products.
A kind of prioritization scheme of bifidobacterium longum feed addictive of the present invention is to be lyophilized first by bifidobacterium longum, sea-buckthorn
Powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then add the fermented egg of surplus
Shell powder is uniformly mixed, and composite packaging is made:Bifidobacterium longum 30000 hundred million -120000 in every 1000g feed addictive
Hundred million, sea-buckthorn freeze-dried powder 10-50g, Rosa roxburghii freeze-dried powder 8-50g, wintercherry freeze-dried powder 5-30g, blackcurrant freeze-dried powder 5-30g, cactus
Freeze-dried powder 70-150g, remaining is fermentation egg-shell meal.
The further prioritization scheme of the present invention is a kind of bifidobacterium longum feed addictive, it is characterized in that first by long double
Discrimination bacillus, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then
The fermentation egg-shell meal for adding surplus is uniformly mixed, and composite packaging is made:The bifidobacterium longum in every 1000g feed addictive
50000 hundred million -120000 hundred million, sea-buckthorn freeze-dried powder 15-50g, Rosa roxburghii freeze-dried powder 12-50g, wintercherry freeze-dried powder 8-30g, blackcurrant
Freeze-dried powder 8-30g, cactus freeze-dried powder 85-150g, remaining is fermentation egg-shell meal.
Further optimization plan of the present invention is a kind of bifidobacterium longum feed addictive, it is characterized in that first by growing
Bifidobacterium, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed,
The fermentation egg-shell meal for adding surplus again is uniformly mixed, and composite packaging is made:The bifidobacterium longum in every 1000g feed addictive
80000 hundred million -120000 hundred million, sea-buckthorn freeze-dried powder 20-50g, Rosa roxburghii freeze-dried powder 15-50g, wintercherry freeze-dried powder 10-30g, it is black plus
Logical sequence freeze-dried powder 10-30g, cactus freeze-dried powder 100-150g, remaining is fermentation egg-shell meal.
Bifidobacterium longum can produce lactic acid and acetic acid after fermenting in animal intestine, can improve the utilization rate of calcium, phosphorus, iron, promote
Into the absorption of iron and vitamin D.Bifidobacterium fermentation lactose generate galactolipin, be constitute cerebral nervous system in it is cerebronic at
Point.Bifidobacterium can produce the nutrients such as vitamin B1, B2, B6, B12 and alanine, valine, aspartic acid and threonine
Matter.Bifidobacterium longum can be used for zooprophylazis and treatment bacterial diarrhea.Bifidobacterium longum be Food and Drug Administration and
Feed management association is considered safe microorganism fodder.The Ministry of Agriculture of China announces No. 2045《Feed addictive catalogue
(2013)》Also it records, is used for animal-breeding microbial bacteria.
Sea-buckthorn(Hippophae rhamnoides Linn.), fruit nutriment rich in and biological active matter
Matter can be widely applied to many fields of the national economy such as food, medicine, light industry, space flight, agriculture and animal husbandry fishery.Fructus hippophae and oil
With very high medical value, there is a cough-relieving apophlegmatic, relieving dyspepsia, promoting blood circulation to remove blood stasis effect, can treat gastric duodenal ulcer with
And indigestion etc..
Sea buckthorn fruit is full of nutrition, according to surveying and determination in its fruit containing multivitamin, fatty acid, microelement, sub- oil element,
The various amino acid of Hippophate flavone, superoxides isoreactivity substance and needed by human body.Wherein Vitamin C content is high, and every 100 grams
In fruit juice, Vitamin C content can reach 825-1100 milligrams, is 2-3 times of Kiwi berry, is known as the laudatory title of the king of vitamin C.Contain
Sugared 7.5%-10%, the 3%-5% containing acid.
Rosa roxburghii Tratt(Rosa roxbunghii)For the fruit of the perennial machaka rosa roxburghii of rosaceae also known as mountain king fruit, thorn
Certain kind of berries fruit, thatch pears etc..With clearing heat and promoting fluid, stomach strengthening and digestion promoting, relieving summer-heat and other effects.Rosa roxburghii Tratt vitamin B rich in, C, carrotene,
The ingredients such as malic acid, citric acid are usually used in deficiency of stomach-Yin, appetite stimulator, indigestion or eating accumulation, glutted full bored, diarrhea
Loose stool;Pyreticosis or hot summer weather hurt saliva, thirsty, scanty drak urine.
Mature Rosa roxburghii Tratt is fleshy hypertrophy, sweet and sour, fruit are rich in sugar, vitamin, carrotene, organic acid and more than 20 kinds of ammonia
More than base acid, 10 microelement and superoxide dismutase, especially Vitamin C content beneficial to human body are high, are to work as
It is highest in preceding fruit, it is 50 times of citrus 841.58 milligrams -3541.13 milligrams of content in every 100 grams of fresh fruits, Kiwi berry
10 times, the laudatory title with " king of vitamin C ".Fruit of Grossularia burejensis Berger has very high nutritive value and medical value, sour, puckery, flat,
Digestion-promoting spleen-invigorating restrains stopping leak, for treating having indigestion abdominal distension, dysentery, enteritis, vitamin C deficiency etc..
Wintercherry(Physali alkekengiL.)Also known as groundcherry, franchet groundcherry persistent calyx or fruit, cape gooseberry etc..Containing more in Fruit of Physalis
Kind of nutritional ingredient, wherein the content of calcium be 73.1 times of tomato, 13.8 times of carrot, ascorbic content is tomato
6.4 times, 5.4 times of carrot.With unique flavor and nutrition abundant.Fruit of Physalis aromatic flavour, delicious.Berry is rich
Containing vitamin C, beta carotene, more than 20 kinds of mineral elements and 18 kinds of amino acid, there is heat-clearing, removing toxic substances, diuresis effect is usually used in
Control heat-syndrome cough, pharyngalgia, jaundice, dysentery, in water, the treatment of furunculosis, erysipelas etc..
Blackcurrant scientific name elements of black currant(Ribes nigrum L.)Also known as currant, purple plum etc., ripening fruits are black
Small berries, it is interior to be rich in vitamin C, anthocyanidin.Blackcurrant is not only a kind of delicious flavour, fruit full of nutrition, and has
Good medicinal efficacy.Blackcurrant fruit is rich in mineral matter element, and the Zn content in mineral matter element is high, can be used as and comes for zinc
Source;Ascorbic content is high, hence it is evident that is higher than citrus, hawthorn, also contains phosphorus, magnesium, potassium, calcium, anthocyanidin, phenolic substances.Seed
Linoleic acid content is high.Ascorbic content is very rich in blackcurrant, it is often more important that is also melted into containing a large amount of antioxygen
Point, this assures ascorbic function and effect.Blackcurrant is rich in such as anthocyanidin, vitamin C, flavones, Quercetin, red bayberry
The substances such as alcohol, phenolic acid, catechin and blackcurrant polysaccharide, these are all the bioactive substances with good anti-oxidation function.
Cactus(Scientific name:Opuntia stricta(Haw.)Haw.var.dillenii(Ker-Gawl.) Benson),
It is a kind of plant of Opuntia.Alias celestial being palm, kwan-yin palm etc..Cactus is the meat shrub that grows thickly, the wide ovum of top branch
Shape, obovate elliptic or subcircular;Flower spoke shape, holder obovate.It is used as medicine with complete stool.The four seasons can adopt.
Cactus is cool in nature, sour, nontoxic.Have the promoting flow of qi and blood circulation, heat-clearing toxin-expelling functions.Mainly have clearing heat and detoxicating, eliminating stasis to subdue swelling,
The functions such as the promoting flow of qi and blood circulation, benefiting stomach and stopping pain.Cactus contains amino acid and various trace elements in needed by human 8, and embraces green
The preciousness ingredient such as lotus, Kok Beattie cents, cholla stem, starches through cactus crude drug and analyzes, contain pectin, polysaccharide and glue exudate.From herb point
From extracting to obtain freidelin ketone(friedelin), -3 α -ol of freidelin(friedelan-3-α-ol), taraxerone
(taraxerone)And taraxerol(taraxerol).
Eggshell, quantity is biggish in China's poultry farming chicken, duck, goose and quail etc., using egg, duck's egg,
As in food processing process, the useless eggshell enormous amount generated is provided according to existing disclosed report for goose egg and quail egg
Material display, the eggshell total amount that a medium-sized city is monthly discarded reach 60-100 tons, and account for egg size by Eggshell weight 11% calculates,
The eggshell that about 1,500,000 tons of the daily output in China, not only pollutes environment, but also waste of resource in this way.Discarded eggshell is integrated
It utilizes, resource utilization can not only be improved and avoids environmental pollution, and be greatly improved the economic benefit and social benefit of enterprise.
Wherein egg shell is in China's yield maximum, and egg shell accounts for the 10-12% in entire egg, by under film, shell on shell
Film and eggshell three parts composition, eggshell is a kind of calcareous hard shell, is located on shell between film and shell lower film.In the change of egg shell
In studying point, minerals account for 95%, and protein 3.3%, moisture 1%, fat 0.03%, remaining is carbohydrate and other have
Machine substance(It certainly, does not include a large amount of remaining egg white in eggshell in the above ingredient).Eggshell mineral ingredient is mainly
Calcium carbonate accounts for 94% or so, remaining is magnesium carbonate and calcium phosphate, and calcium, phosphorus content account for 34.9% and of eggshell dry matter respectively
0.2%.In eggshell, seven kinds of vitamins and various trace elements and some important enzymes, peptide matters can be measured, he
Although content seldom, be all the substance needed in human body or animal body.
In the prior art, it is replenished the calcium with egg-shell meal, has the product of the grinds after sterilizing by eggshell in people's product, also have
The application of organic calcium is prepared into using primary or secondary clacining method.It is at present most widely in drug, food and nutriment
In preparation, micron order, submicron order and nano level superfine powder are mostly used, is added to various food, nutrition kind, has reached very
Good effect.Application of the eggshell in China's animal-breeding is taken mostly by eggshell cleaning, drying, and milling is added into feed
The method of feeding, since grinding particle size is larger, being absorbed and utilized for animal is poor, can't reach good application effect.
The present invention is first to be ground into coarse powder by after eggshell cleaning, high temperature drying, fermented using saccharomycete, then again
Carbonyl ammonia reaction treatment is carried out, then dried, crush and be prepared into biological calcium product, the program not only improves what eggshell utilized
Nutrition, while the main composition-calcium carbonate in eggshell being made to obtain biochemical reaction, the biological calcium carbonate for being more conducive to absorb is formed,
The reaction of carbonyl ammonia makes its protein component be further converted to amino acid again, makes the protein, amino acid converting for small peptide of macromolecular
Or the small-molecule substances such as small peptide, the beneficial effect for reaching collection eutrophy and being absorbed and utilized.
The beneficial effects of the invention are as follows:
(1)Product of the present invention is single type bifidobacterium longum additive, can have to producer's offer and targetedly select
With use, product can highlight the viable bacteria content of bifidobacterium longum.Survival rate of the thallus in closed composite packaging is significantly improved,
Through batches of products reserved sample observing 12 months at room temperature, bifidobacterium longum average viability is 92.6%, and reference substance(It is right
Filler according to product is wheat bran)In bifidobacterium longum survival rate be 63.7%;
(2)Pass through sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder and long bifid
Bacillus mixes, and due to the stickum in the colloidal substance that these dry powder formulations are rich in, especially cactus, can preferably increase
Adhesive effect between additive and feed, and improve the utilization rate of additive;
(3)By sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus freeze-dried powder high-content amino acid, vitamin, mineral element, more
Sugar.The nutritional ingredients such as the vitamin C of organic acid, especially high-content and various bioactivators, to raising animal immune energy
Power is simultaneously obviously improved meat, Egg Quality, the acidic materials in especially above-mentioned dry powder, utilization, promotion animal to contained microorganism
Digestion all has significant effect;
(4)Due to using Freeze Drying Technique means, enable sea-buckthorn obtained, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus freeze-dried powder
Its active constituent is maximumlly remained, has distinctive sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, the smell of cactus application and taste
Taste, free from extraneous odour add the preference of animal.
(5)Using egg-shell meal first through saccharomycetes to make fermentation, carbonyl ammonia is then used(Maillard reaction)Reaction is prepared into rich in life
The fermentation egg-shell meal of object calcium, not only makes the calcium carbonate in eggshell obtain bioconversion, obtains the BIOLOGICAL CALCIUM for being conducive to animal absorption,
And further converted to a large amount of protein, amino acid, carbohydrate is formed after saccharomycetes to make fermentation, make amino
Acid, small peptide or small peptide small-molecule substance get a promotion, and more conducively animal is absorbed and utilized, and pass through what conversion carbohydrate was formed
Inverted sugar and fragrance matter further improve the flavor and taste of product, increase animal to the preference of product.
(6)To the preparation of sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus freeze-dried powder in the present invention, do not remove the peel, deseeding step
Suddenly, it is therefore an objective to by being crushed after freeze-drying, so that its skin and seed is worn into fine powder, make anthocyanidin, oil in its skin and seed
Class, organic acid, bud fragrance substance are retained, and the nutritive value of its freeze-dried powder is promoted.
(7)The present invention is lyophilized using sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus
Powder, matrix of the fermentation egg-shell meal as additive contain constants such as a large amount of calcium, phosphorus, potassium, sodium, magnesium, zinc and micro in matrix
Element, vitamin C still rich in, anthocyanidin, beta carotene, malic acid, citric acid, protein, amino acid, nucleic acid, Portugal
Grape sugar, lipoidis, carbohydrate, B family vitamin such as B1、B2、B6、B12And the physiological activity such as folic acid, niacin, pantothenic acid, inositol
Substance, not only improves the nutritive value of bifidobacterium longum additive, while promoting the metabolism of animal, improves the disease-resistant of body
Ability promotes growth of animal, finally improves the economic benefit of its aquaculture.
(8)Product of the present invention uses interior outer bag composite packaging, and interior outer bag interlayer is filled with silica-gel desiccant, and product does not return
Tide, no agglomeration, product is loose, good fluidity, can preferably keep exterior quality and inherent quality.
Operation to not having its technical process stated in detail in the present invention is in the common sense of those skilled in the art
Operation.With regard to the purchase and storage of heretofore described sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant fresh fruit and fresh cactus, the present invention
The construction of people's unit has 20,000 tons of freezer facility, has enough guarantees to storage fresh fruit material.
Specific embodiment
Embodiment 1
The preparation of sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder:
Sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, the cactus for taking fresh mature respectively remove carpopodium, the impurity such as rotten fruit, with containing heavy
40 DEG C of aqueous solutions of 0.1% citric acid are measured, 15min is rinsed under constant stirring and pulls out, be put into pure water and rinse 3 times, pull out
It is drained;It will be moved into refrigerator after sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus sabot respectively, be cooled to -45 DEG C rapidly
Below;Respectively by the sea-buckthorn freezed, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus move into lyophilization machine in, sublimation temperature control-
22--32 DEG C, vacuum degree 120-150Pa makes dry materials to moisture < 6%(w), the time about needs 18 hours, is put into after taking-up
In freezing crusher, control temperature of charge is no more than 0 DEG C, after being crushed to 100 mesh of fineness >, respectively obtains sea-buckthorn freeze-dried powder, thorn
Pears freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder, are fitted into polybag and seal, and are stored in 0 DEG C or less
It is spare in freezer.
Embodiment 2
Using the culture medium accordingly optimized, candida utili, torrid zone vacation are individually cultivated using Liquid Culture Zymolysis Equipment
Silk yeast, brewer's yeast, brewer's yeast and fodder yeast, are then separated the thallus in fermentation liquid with supercentrifuge,
It is with vacuum freeze drying mode that bacterium mud is dry, respectively obtain candida utili dry powder that viable bacteria content is 200 hundred million/grams,
Candida tropicalis dry powder that viable bacteria content is 200 hundred million/grams, the brewer's yeast dry powder that viable bacteria content is 200 hundred million/grams, work
The feed yeast powder that the brewer's yeast dry powder and viable bacteria content that bacterial content is 200 hundred million/grams are 200 hundred million/grams.
Embodiment 3
The preparation of fermentation egg-shell meal:
One or more of mixing eggshells of egg shell or Ovum Anas domestica putamina, goose egg-shell, quail eggshell are cleaned up, moisture is dried, sets
Enter in baking oven, under the conditions of 260 DEG C after heated-air drying 2 hours, taking-up is let cool, and is ground into 45 mesh powder;80 kilograms of egg-shell meal are weighed,
Suitable pure water, which is added, makes into material moisture 50%(W), it is public to add the feed yeast powder 20 that embodiment 2 obtains
Jin, mixes well rear sabot, is placed in fermenting cellar, ferments 60-72 hours under the conditions of temperature is 31-33 DEG C, to after fermentation,
It is 82 DEG C -92 DEG C, under the conditions of temperature is 80-90% that fermentation materials, which are adjusted to temperature, carries out carbonyl ammonia and reacts 22-28 days, then
Material is dried to moisture content < 5% under the conditions of being not more than 100 DEG C using electric baking case(W), utilize Universalpulverizer
It is crushed, crosses 100 sieves to get fermentation egg-shell meal.
With the preparation method of the fermentation egg-shell meal of embodiment 3, it is dry that candida utili obtained in embodiment 2 can be respectively adopted
Powder, candida tropicalis dry powder, brewer's yeast dry powder or brewer's yeast dry powder carry out preparation fermentation egg-shell meal, other process conditions
Implemented according to eggshell powder preparation technique parameter of fermenting in the claim of this application 1-4.
Embodiment 4
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 10000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 5g, Rosa roxburghii freeze-dried powder 50g, acid
Freeze-dried powder 3g, blackcurrant freeze-dried powder 3g, cactus freeze-dried powder 150g are starched, remaining is fermentation egg-shell meal;Specifically production method is:Claim
The difference of Example 1 sea-buckthorn freeze-dried powder obtained, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder
It mixes, then bifidobacterium longum dry powder is uniformly admixed, then add the surplus egg-shell meal that ferments as made from embodiment 3 and be sufficiently mixed
After uniformly, composite packaging is carried out;Composite packaging is inner bag using polypropylene plastics pocket, and outer bag uses aluminium foil bag, between interior outer bag
Add a few packet silica-gel desiccants, to prevent water suction.
Embodiment 5
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 30000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 45g, Rosa roxburghii freeze-dried powder 8g, acid
Freeze-dried powder 5g, blackcurrant freeze-dried powder 5g, cactus freeze-dried powder 145g are starched, remaining is fermentation egg-shell meal;Specific production method is the same as real
Apply example 4.
Embodiment 6
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 50000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 45g, Rosa roxburghii freeze-dried powder 15g,
Wintercherry freeze-dried powder 10g, blackcurrant freeze-dried powder 10g, cactus freeze-dried powder 90g, remaining is fermentation egg-shell meal;Specific production method is same
Embodiment 4.
Embodiment 7
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 80000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 25g, Rosa roxburghii freeze-dried powder 15g,
Wintercherry freeze-dried powder 15g, blackcurrant freeze-dried powder 12g, cactus freeze-dried powder 100g, remaining is fermentation egg-shell meal;Specific production method
With embodiment 4.
Embodiment 8
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 85000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 10g, Rosa roxburghii freeze-dried powder 30g,
Wintercherry freeze-dried powder 20g, blackcurrant freeze-dried powder 15g, cactus freeze-dried powder 110g, remaining is fermentation egg-shell meal;Specific production method
With embodiment 4.
Embodiment 9
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 90000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 25g, Rosa roxburghii freeze-dried powder 50g,
Wintercherry freeze-dried powder 20g, blackcurrant freeze-dried powder 20g, cactus freeze-dried powder 120g, remaining is fermentation egg-shell meal;Specific production method
With embodiment 4.
Embodiment 10
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 100000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 50g, Rosa roxburghii freeze-dried powder 30g,
Wintercherry freeze-dried powder 30g, blackcurrant freeze-dried powder 30g, cactus freeze-dried powder 115g, remaining is fermentation egg-shell meal;Specific production method
With embodiment 4.
Embodiment 11
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 110000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 50g, Rosa roxburghii freeze-dried powder 40g,
Wintercherry freeze-dried powder 20g, blackcurrant freeze-dried powder 20g, cactus freeze-dried powder 125g, remaining is fermentation egg-shell meal;Specific production method
With embodiment 4.
Embodiment 12
A kind of bifidobacterium longum feed addictive is frozen by bifidobacterium longum dry powder, sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry
Dry powder, blackcurrant freeze-dried powder, cactus freeze-dried powder be uniformly mixed, then add surplus fermentation egg-shell meal be uniformly mixed, compound packet
Dress is made:The bifidobacterium longum 120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-dried powder 50g, Rosa roxburghii freeze-dried powder 50g,
Wintercherry freeze-dried powder 25g, blackcurrant freeze-dried powder 25g, cactus freeze-dried powder 50g, remaining is fermentation egg-shell meal;Specific production method is same
Embodiment 4.
Claims (10)
1. a kind of bifidobacterium longum feed addictive, it is characterized in that being lyophilized first by bifidobacterium longum, sea-buckthorn freeze-dried powder, Rosa roxburghii Tratt
Powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then add the fermentation egg-shell meal mixing of surplus
Even, composite packaging is made:Bifidobacterium longum 10000 hundred million -120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-drying
Powder 5-50g, Rosa roxburghii freeze-dried powder 5-50g, wintercherry freeze-dried powder 3-30g, blackcurrant freeze-dried powder 3-30g, cactus freeze-dried powder 50-
150g, remaining is fermentation egg-shell meal;The sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, celestial being
People slaps freeze-dried powder, is made by following methods, and technical process is to take fresh sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, celestial being respectively
The palm removes carpopodium, the impurity such as rotten fruit, and rinsing, freezing, lyophilization, low-temperature grinding are not removed the peel, deseeding step;It is described above
Rinsing condition be to be rinsed 15min, and be stirred continuously, pulled out and be put into pure water with the citric acid of 40 DEG C of water addition weight 0.1%
Middle rinsing 3 times;Above-mentioned freezing be will be cooled to rapidly after sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus sabot respectively -45 DEG C with
Under;The process conditions of above-mentioned lyophilization are temperature-22-- 32 DEG C, vacuum degree 120-150Pa, it is dry to moisture less than 6%/
Until w;The fermentation egg-shell meal, is to clean up eggshell, dries moisture, is dried 1-2 hours, then crushes in advance
At 40-50 mesh powder, suitable water, which is added, makes into water content in 45-55%/w, and the saccharomycete for adding egg-shell meal weight 20% is mixed
It is even, it ferments 60-72 hours under the conditions of temperature is 31 DEG C -33 DEG C, after fermentation, it is 82- that fermentation materials, which are adjusted to temperature,
92 DEG C, humidity be 80-90% under the conditions of carry out carbonyl ammonia react 22-28 days, then, by material use electric baking case be not more than
It is dried to moisture content < 5%/w under the conditions of 100 DEG C, is crushed, sieved with 100 mesh sieve to obtain the final product.
2. a kind of bifidobacterium longum feed addictive, it is characterized in that being lyophilized first by bifidobacterium longum, sea-buckthorn freeze-dried powder, Rosa roxburghii Tratt
Powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then add the fermentation egg-shell meal mixing of surplus
Even, composite packaging is made:Bifidobacterium longum 30000 hundred million -120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-drying
Powder 10-50g, Rosa roxburghii freeze-dried powder 8-50g, wintercherry freeze-dried powder 5-30g, blackcurrant freeze-dried powder 5-30g, cactus freeze-dried powder 70-
150g, remaining is fermentation egg-shell meal;The sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, celestial being
People slaps freeze-dried powder, is made by following methods, and technical process is to take fresh sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, celestial being respectively
The palm removes carpopodium, the impurity such as rotten fruit, and rinsing, freezing, lyophilization, low-temperature grinding are not removed the peel, deseeding step;It is described above
Rinsing condition be to be rinsed 15min, and be stirred continuously, pulled out and be put into pure water with the citric acid of 40 DEG C of water addition weight 0.1%
Middle rinsing 3 times;Above-mentioned freezing be will be cooled to rapidly after sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus sabot respectively -45 DEG C with
Under;The process conditions of above-mentioned lyophilization are temperature-22-- 32 DEG C, vacuum degree 120-150Pa, it is dry to moisture less than 6%/
Until w;The fermentation egg-shell meal, is to clean up eggshell, dries moisture, is dried 1-2 hours, then crushes in advance
At 40-50 mesh powder, suitable water, which is added, makes into water content in 45-55%/w, and the saccharomycete for adding egg-shell meal weight 20% is mixed
It is even, it ferments 60-72 hours under the conditions of temperature is 31 DEG C -33 DEG C, after fermentation, it is 82- that fermentation materials, which are adjusted to temperature,
92 DEG C, humidity be 80-90% under the conditions of carry out carbonyl ammonia react 22-28 days, then, by material use electric baking case be not more than
It is dried to moisture content < 5%/w under the conditions of 100 DEG C, is crushed, sieved with 100 mesh sieve to obtain the final product.
3. a kind of bifidobacterium longum feed addictive, it is characterized in that being lyophilized first by bifidobacterium longum, sea-buckthorn freeze-dried powder, Rosa roxburghii Tratt
Powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then add the fermentation egg-shell meal mixing of surplus
Even, composite packaging is made:Bifidobacterium longum 50000 hundred million -120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-drying
Powder 15-50g, Rosa roxburghii freeze-dried powder 12-50g, wintercherry freeze-dried powder 8-30g, blackcurrant freeze-dried powder 8-30g, cactus freeze-dried powder 85-
150g, remaining is fermentation egg-shell meal;The sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, celestial being
People slaps freeze-dried powder, is made by following methods, and technical process is to take fresh sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, celestial being respectively
The palm removes carpopodium, the impurity such as rotten fruit, and rinsing, freezing, lyophilization, low-temperature grinding are not removed the peel, deseeding step;It is described above
Rinsing condition be to be rinsed 15min, and be stirred continuously, pulled out and be put into pure water with the citric acid of 40 DEG C of water addition weight 0.1%
Middle rinsing 3 times;Above-mentioned freezing be will be cooled to rapidly after sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus sabot respectively -45 DEG C with
Under;The process conditions of above-mentioned lyophilization are temperature-22-- 32 DEG C, vacuum degree 120-150Pa, it is dry to moisture less than 6%/
Until w;The fermentation egg-shell meal, is to clean up eggshell, dries moisture, is dried 1-2 hours, then crushes in advance
At 40-50 mesh powder, suitable water, which is added, makes into water content in 45-55%/w, and the saccharomycete for adding egg-shell meal weight 20% is mixed
It is even, it ferments 60-72 hours under the conditions of temperature is 31 DEG C -33 DEG C, after fermentation, it is 82- that fermentation materials, which are adjusted to temperature,
92 DEG C, humidity be 80-90% under the conditions of carry out carbonyl ammonia react 22-28 days, then, by material use electric baking case be not more than
It is dried to moisture content < 5%/w under the conditions of 100 DEG C, is crushed, sieved with 100 mesh sieve to obtain the final product.
4. a kind of bifidobacterium longum feed addictive, it is characterized in that being lyophilized first by bifidobacterium longum, sea-buckthorn freeze-dried powder, Rosa roxburghii Tratt
Powder, wintercherry freeze-dried powder, blackcurrant freeze-dried powder, cactus freeze-dried powder are uniformly mixed, then add the fermentation egg-shell meal mixing of surplus
Even, composite packaging is made:Bifidobacterium longum 80000 hundred million -120000 hundred million in every 1000g feed addictive, sea-buckthorn freeze-drying
Powder 20-50g, Rosa roxburghii freeze-dried powder 15-50g, wintercherry freeze-dried powder 10-30g, blackcurrant freeze-dried powder 10-30g, cactus freeze-dried powder
100-150g, remaining is fermentation egg-shell meal;The sea-buckthorn freeze-dried powder, Rosa roxburghii freeze-dried powder, wintercherry freeze-dried powder, blackcurrant freeze-drying
Powder, cactus freeze-dried powder, are made by following methods, technical process be take respectively fresh sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant,
Cactus removes carpopodium, the impurity such as rotten fruit, and rinsing, freezing, lyophilization, low-temperature grinding are not removed the peel, deseeding step;It is above-mentioned
The rinsing condition is to rinse 15min, and be stirred continuously with the citric acid of 40 DEG C of water addition weight 0.1%, pull out be put into it is pure
It is rinsed 3 times in water purification;Above-mentioned freezing is will to be cooled to rapidly -45 after sea-buckthorn, Rosa roxburghii Tratt, wintercherry, blackcurrant, cactus sabot respectively
DEG C or less;The process conditions of above-mentioned lyophilization are temperature-22-- 32 DEG C, and vacuum degree 120-150Pa is dried to moisture and is less than
Until 6%/w;The fermentation egg-shell meal, is to clean up eggshell, dries moisture, in advance drying process 1-2 hours, then
It is ground into 40-50 mesh powder, suitable water, which is added, makes into water content in 45-55%/w, adds the yeast of egg-shell meal weight 20%
Bacterium is mixed thoroughly, is fermented 60-72 hours under the conditions of temperature is 31 DEG C -33 DEG C, after fermentation, fermentation materials, which are adjusted to temperature, is
82-92 DEG C, humidity be 80-90% under the conditions of carry out carbonyl ammonia react 22-28 days, then, by material use electric baking case not
It is dried to moisture content < 5%/w under the conditions of greater than 100 DEG C, is crushed, sieved with 100 mesh sieve to obtain the final product.
5. a kind of bifidobacterium longum feed addictive as described in claim 1-4, which is characterized in that the bifidobacterium longum,
200 hundred million thalli dry powder products are no less than containing viable bacteria concentration for every gram.
6. a kind of bifidobacterium longum feed addictive as described in claim 1-4, which is characterized in that the low-temperature grinding is object
Material temperature degree is in 0 DEG C or less and is crushed.
7. a kind of bifidobacterium longum feed addictive as described in claim 1-4, which is characterized in that the composite packaging uses
Interior outer bag composite packaging, inner bag use polypropylene plastics pocket, and outer packing uses aluminium foil bag, is filled with silica dehydrator between interior outer bag
Agent pouch.
8. a kind of bifidobacterium longum feed addictive as described in claim 1-4, which is characterized in that the eggshell is egg
Any one or a few mixing eggshell in shell, Ovum Anas domestica putamina, goose egg-shell and quail eggshell.
9. a kind of bifidobacterium longum feed addictive as described in claim 1-4, which is characterized in that the drying uses hot wind
Dry or far-infrared ray drying;The drying condition is 180 DEG C -300 DEG C.
10. a kind of bifidobacterium longum feed addictive as described in claim 1-4, which is characterized in that the saccharomycete is to produce
Any one in protein Candida, candida tropicalis, brewer's yeast, brewer's yeast and fodder yeast.
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