CN108836237A - A kind of sampling capsule with sampling pool sealing structure - Google Patents
A kind of sampling capsule with sampling pool sealing structure Download PDFInfo
- Publication number
- CN108836237A CN108836237A CN201810617882.4A CN201810617882A CN108836237A CN 108836237 A CN108836237 A CN 108836237A CN 201810617882 A CN201810617882 A CN 201810617882A CN 108836237 A CN108836237 A CN 108836237A
- Authority
- CN
- China
- Prior art keywords
- spring
- piston
- sampling
- capsule
- hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
Abstract
The present invention relates to a kind of sampling capsules with sampling pool sealing structure, including capsule housing, piston, spring, waterproof cover, heater, capsule sensing and control module, spring supporting ring, thieff hatch closeouts and meltable spring fastener, the outer ring of spring supporting ring is sealedly and fixedly connected with capsule housing inner wall, the inner ring of spring supporting ring and the opening portion of waterproof cover are sealedly and fixedly connected, it is separated between electric control element storehouse and sampling pool by spring supporting ring and waterproof cover sealing, it is separated between sampling pool and medicine storehouse by piston seal, release hole is offered on capsule housing, the release hole is sealed by sealing-plug, the medicine storehouse sealing plate in medicine storehouse is equipped with the through-hole that can be connected to release hole, through-hole uses oil sealing, capsule sensing and control module are arranged in electric control element storehouse, heater is arranged in waterproof cover.The present invention is provided simultaneously with sampling and release function, and is all active mode, has stronger sampling power and better controllability.
Description
Technical field
The present invention relates to the field of medical instrument technology, and in particular to a kind of sampling capsule with sampling pool sealing structure.
Background technique
The ideal structure of sampling capsule is that sampling pool closing, does not contact with the external world, keep the cleaning of sampling pool before sampling；
Sampling pool is open enough when sampling, guarantee interested sample can smoothly, sufficiently be adopted into；After sampling, sampling pool
It closes again, on the one hand can guarantee that sample will not be revealed, on the other hand guarantee in capsule system during excreting,
Sample is not contaminated.Sampling pool in current many design cannot all be closed again, therefore there are sample leakages or contaminated
It may (such as Gu and Gu, 1996, bibliography " Ingestibel Gastrointestinal Sampling Devices：
State-of-the-Art and Future Directions”)。
In view of the above-mentioned problems, the Chinese patent of Publication No. CN1820798A《Capsule type digestive tract medicine release and sampling
Device》Disclose a kind of using spring while the capsule system that is sampled and released the drug, in the program, before sampling, piston is stifled
Firmly check valve, sampling pool closing.After sampling starts, spring pushes piston to move right, and pressure official post outside liquid passes through unidirectional
Valve enters sampling pool.After sampling, the valve block of check valve acts on ShiShimonoseki valve closing door in own resilient.The patent is substantially met
Sampling pool closed demand, but the design has the following insufficient：The first, the patent is not described in detail check valve
Structure；The second, when ambient pressure improves, check valve can not prevent the substance at other positions from entering back into capsule；
The Chinese patent of Publication No. CN201719266U《A kind of mini device for sampling liquid of alimentary canal》Disclose one kind
Using the passive sampling capsule system of micro machine, in a kind of scheme of the patent, sampling pool can rotate under the driving of micro machine.
The thief hatch of sampling pool mouth and capsule shell is staggered before sampling, sampling pool sealing.Micro motor for driving sampling pool rotates when sampling, adopts
Sample pond is aligned with thief hatch, starts Passive intake body fluid.After sampling, micro machine drives sampling pool to rotate again, thief hatch
It is staggered again, sampling pool sealing.Another scheme of the patent is that rotation is converted to straight line fortune by transmission mechanism by micro machine
Dynamic, thief hatch is staggered when beginning, and when sampling pushes sampling pool to be aligned thief hatch, and pushing again after sampling makes thief hatch be staggered.This
Kind scheme has preferable controllability by means of micro machine, but still has following many deficiencies：The first, closing mode relies on micro- electricity
Machine, micro-motor power is small, volume is big, energy consumption is high；The second, sample mode is passive sampling, and infiltration rate is slow；Third, the system
There is no release function.
The Chinese patent of Publication No. CN106725634A《Enteric microorganism acquires capsule》Disclosing a kind of utilization can drop
The acquisition capsule system of material and spring is solved, which uses degradable material, can degrade in specific digestive juice, to discharge
Spring is allowed to extend, and pushes piston.Before starting sampling, thieff hatch is made into plug seal with same degradation material.Sampling
When, plug is first degraded and is finished, and liquid enters capsule by thieff hatch.Due to the gradually degradation of degradable part, spring, which pushes, lives
Plug seals liquid into sampling pool.With further degradation, line bolt moves at thieff hatch, under the action of elastic force, line bolt
Thieff hatch is blocked in pop-up, closes sampling pool, and sampling terminates.The structural disadvantages are：The first, use degradable material as triggering machine
System, specific triggered time are difficult to control；The second, sampled targets are limited by degradation material, need to understand target liq in advance
Property selects suitable degradation material；Third, passive sampling；4th, do not have release function.
The Chinese patent of Publication No. CN201453300U《Digestive canal sampler》Disclose a kind of sampling of pneumatic type
Capsule system, after which is triggered, fuse easy fuse release spring, and thimble is pushed to puncture air bag.Air bag is deflated to be arranged from the right
Stomata sprays.Deflated balloon, the contraction process of left end air bag generate low pressure and absorb body fluid by thieff hatch.It is provided at thief hatch
Switch, by plug, spring and filament composition.Before sampling, plug is in the open state under the elastic force effect of spring, filament pine
It relaxes.During sampling carries out, air bag pulls filament constantly to the right, and gradually filament is straightened.Filament overcomes spring, pulls plug, will
Thieff hatch is blocked, and sampling terminates.This design uses pneumatic mode, and triggering is completed by compressed spring.The structural disadvantages are：The
One, sampling pool is sealed by the air bag of expansion before sampling, but actually air bag can still be contacted with the external world；The second, before sampling terminates
Plug is in pop-up state, is unfavorable for the intake of capsule and in movement in the digestive tract；Third does not have release function.
Summary of the invention
The purpose of the present invention is to provide a kind of sampling capsule with sampling pool sealing structure, which, which is provided simultaneously with, is adopted
Sample and release function, and be all active mode, there is stronger sampling power and better controllability.
In order to solve the above technical problems, a kind of sampling capsule with sampling pool sealing structure disclosed by the invention, special
Sign is：It include capsule housing, piston, spring, waterproof cover, heater, capsule sensing and control module, spring supporting ring,
Thieff hatch closeouts and meltable spring fastener, outer ring and the capsule housing inner wall of spring supporting ring are sealedly and fixedly connected, spring
The inner ring of support ring and the opening portion of waterproof cover are sealedly and fixedly connected, wherein capsule housing include electric control element storehouse, sampling pool and
Medicine storehouse is separated between electric control element storehouse and sampling pool by spring supporting ring and waterproof cover sealing, by living between sampling pool and medicine storehouse
Plug sealing separates, and release hole is offered on capsule housing, which is sealed by sealing-plug, and the medicine storehouse sealing plate in medicine storehouse is equipped with
The through-hole that can be connected to release hole, through-hole use oil sealing, and capsule sensing and control module are arranged in electric control element storehouse, heater
It is arranged in waterproof cover, spring is located in sampling pool, and one end of spring is connect with spring supporting ring, and the other end of spring, which connects, lives
Plug, spring are limited in compressive state by meltable spring fastener, and the heating head of heater can be by adding meltable spring fastener
Temperature makes meltable spring fastener release the fastening to spring-compressed state, and piston is equipped with thieff hatch closeouts, on capsule housing
Equipped with thieff hatch, piston can block thieff hatch in spring-compressed state, and thieff hatch closeouts can be in spring the fully extended state
Under block thieff hatch, thieff hatch can be connected to sampling pool when piston and thieff hatch closeouts are not blocked, set on piston
There is the intercommunicating pore that sampling pool can be made to be connected to medicine storehouse, which is blocked by the first rubber stopper, capsule sensing and control module
Heat the control signal input of control signal output connection heater.
Beneficial effects of the present invention：
1, the present invention can be sampled and be released the drug simultaneously；Sampling and drug release are all the functions of the needs such as raw doctor's research, treatment, when with
Family it should be understood that in specific alimentary system situations such as microorganism, physiological parameter while need at this discharge medicament when, one
Capsule of the invention can be completed, and guarantee that two kinds of operations are completed in same alimentary canal region.It avoids taking more capsules,
And it avoids taking more capsules being to be easy existing position error.
2, the sampling and release that the present invention designs are active mode, and the active mode refers to containing specified power source,
The mode acted under instruction.Opposite " passive mode " is often referred to：Using containing water-absorbing material adsorption sample,
Opening medicine storage room makes drug permeate automatically, flow into alimentary canal etc..Therefore, active mode has several benefits：
2.1, operability is stronger, can be according to preset program or operation start instruction；
2.2, contain driving force, sampling and rate of release are expectable, and more rapidly, delay it is small, positioning accuracy is higher.
3, the sampling pool in the present invention is all closed afterwards before sampling, guarantees that sample is not contaminated and will not reveal.
4, the closing mode for the thief hatch that the present invention designs has preferable versatility, is suitable for a variety of power sources.
Detailed description of the invention
Fig. 1 is 1 original state structural schematic diagram of embodiment；
Fig. 2 is the structural schematic diagram at the end of the sampling of embodiment 1, release；
Fig. 3 is 2 original state structural schematic diagram of embodiment；
Fig. 4 is the structural schematic diagram at the end of the sampling of embodiment 2, release；
Fig. 5 is 3 original state structural schematic diagram of embodiment；
Fig. 6 is the structural schematic diagram at the end of the sampling of embodiment 3, release；
Fig. 7 is the structural schematic diagram of embodiment 4.
Wherein, 101-capsule housings, 102-release holes, 103-through-holes, 104-medicine storehouses, 105-pistons, 106-the
One rubber stopper, 107-thieff hatch, 108-intermediate channels, 109-tubular connection pieces, 110-sampling pools, 111-springs,
112-waterproof covers, 113-heaters, 114-easy fuses, 115-heating heads, 116-capsules sensing and control module, 117-
Second rubber stopper, 118-spring supporting rings, 119-medicine storehouse sealing plates, 120-electric control element storehouses, 121-piston rings, 201-
Line, 202-O-shaped rubber rings, 301-sampling capsule systems, 302-elastic waterproof layers, 303-O shape pistons, 304-radial directions are logical
Hole, 305-thief hatch, 306-waterproof jackets, 307-elastic water-proof films, 308-rubber plugs, 309-arc-shaped pistons.
Specific embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail：
A kind of sampling capsule with sampling pool sealing structure that embodiment 1 designs, as illustrated in fig. 1 and 2, it includes capsule
Shell 101, piston 105, spring 111, waterproof cover 112, heater 113, capsule sensing and control module 116, spring supporting ring
118, thieff hatch closeouts and meltable spring fastener, the outer ring of spring supporting ring 118 and the sealing of 101 inner wall of capsule housing are fixed
Connection, the opening portion of the inner ring and waterproof cover 112 of spring supporting ring 118 is sealedly and fixedly connected, wherein capsule housing 101 includes
Electric control element storehouse 120, sampling pool 110 and medicine storehouse 104 (liquid medicine or powder medicaments can be stored), electric control element storehouse 120 with adopt
It is separated between sample pond 110 by spring supporting ring 118 and the sealing of waterproof cover 112, by piston 105 between sampling pool 110 and medicine storehouse 104
Sealing separates, and release hole 102 is offered on capsule housing 101, which is sealed by sealing-plug (such as rubber stopper), medicine storehouse
104 medicine storehouse sealing plate 119 is equipped with the through-hole 103 that can be connected to release hole 102, and through-hole 103 uses oil sealing (such as mineral oil),
Capsule sensing and control module 116 are arranged in electric control element storehouse 120, and heater 113 is arranged in waterproof cover 112, spring 111
In sampling pool 110, one end of spring 111 is fixedly connected with spring supporting ring 118, and the other end of spring 111 is fixedly connected
Piston 105, spring 111 are limited in compressive state by meltable spring fastener, and the heating head 115 of heater 113 can be by easy
Molten spring fastener heating, makes meltable spring fastener release the fastening to 111 compressive state of spring, and piston 105 is equipped with and adopts
Sample hole closeouts, capsule housing 101 are equipped with thieff hatch 107, and piston 105 can block thieff hatch in 111 compressive state of spring
107, sampling pool 110 is closed, thieff hatch closeouts can block thieff hatch 107, closing sampling under 111 the fully extended state of spring
Pond 110, thieff hatch 107 can be connected to when piston 105 and thieff hatch closeouts are not blocked with sampling pool 110, piston 105
It is equipped with the intercommunicating pore that sampling pool 110 can be made to be connected to medicine storehouse 104, which blocks (first rubber by the first rubber stopper 106
Rubber plug 106 is soft rubber plug, can be inserted into syringe needle for recycling sample, soft rubber plug when syringe needle is extracted from sampling pool 110
Still seal sampling pool 110), the control of the heating control signal output connection heater 113 of capsule sensing and control module 116
Signal input part processed.Capsule sensing and control module 116 are by pH sensor, imaging sensor, microprocessor and communication module collection
At forming.
In embodiment 1, dry thieff hatch 107 has several, and thieff hatch 107 is distributed in 101 side of capsule housing.
In embodiment 1, the meltable spring fastener can be meltable silk 114, offer on the spring supporting ring 118
Two holes are blocked respectively by two the second rubber stoppers 117 on above-mentioned two hole, and one end of the easy fuse 114 passes through one the
It is fixedly connected after two rubber stoppers 117 with thieff hatch closeouts, the other end of easy fuse 114 passes through another second rubber stopper 117
It is fixedly connected afterwards with thieff hatch closeouts, the heating head 115 of heater 113 is contacted with easy fuse 114.Easy fuse 114 is by eutectic
Point material is made, and such as nylon, low-melting-point metal or hot melt adhesive, fusing point is 80~90 DEG C.The shown easy fuse 114 of fusing passes through glue
The sealing device of rubber stopper is set at intracapsular partition, and after the easy fuse 114 that fuses is extracted out, rubber stopper is shunk automatically, makes sampling pool 110
Still in sealing state.
In embodiment 1, the inner wall of the piston 105 and capsule housing 101 is interference fit, the piston ring 121 and glue
The inner wall of softgel shell body 101 is interference fit.Play the role of sealing.
Meltable spring fastener described in embodiment 1 can also be hot melt adhesive, the heating head 115 of the heater 113 with
Hot melt adhesive contact.Hot melt adhesive constrains the spring of compression, when the heating head 115 of heater 113 heats hot melt adhesive, reaches
It is merged to assigned temperature hot melt adhesive, spring expansion.
In embodiment 1, the thieff hatch closeouts are piston ring 121, and piston ring 121 is by tubular connection piece 109 and lives
Plug 105 is fixedly connected, and the piston ring 121 can block thieff hatch 107, tubular connection piece under 111 the fully extended state of spring
109 side wall is equipped with the intermediate channel 108 for being connected to thieff hatch 107 and sampling pool 110.In addition, above-mentioned piston ring 121,
Tubular connection piece 109 can be an integral structure with piston 105.
Piston 105 is equal with the stroke L2 of piston 105 with the centre distance L1 of piston ring 121, i.e. L1=L2.Preferably,
L1, L2 take 4mm or more, such as 4~10mm, which can guarantee the capacity in sampling pool 110 and medicine storehouse 104 in 0.3mL or more.
In embodiment 1,101 length of capsule housing is within 30mm, and diameter is within 12mm.
In embodiment 1, under original state, piston 105 blocks thieff hatch 107, closes sampling pool 110.Piston ring 121 and work
105 rigid connection of plug, intermediate channel 108 make the sample of sucking flow into sampling pool 110.It is compressive state when spring 111 is initial,
Easy fuse 114 limits spring 111.Heater 115 is contacted with easy fuse 114.Waterproof cover 112 by the circuit part of capsule with
Sampling pool 110 separates.Capsule sensing and control module 116 include pH sensor, imaging sensor, microprocessor, communication unit
Equal parts.
The working principle of embodiment 1 is：
After the sensor in capsule sensing and control module 116 determines that capsule reaches preset alimentary canal position,
Trigger signal is sent, heater 113 is started to work after being connected to trigger signal, and the heating head 115 of heater 113 reaches assigned temperature
After fuse easy fuse 114, thus release spring 111.Spring 111 pushes piston 105 to squeeze medicine storehouse 104, makes drug from release hole
102 spray.At the same time, piston 105 leaves original position, and thieff hatch 107 is open, due to the low pressure in sampling pool 110, exterior materials
It is inhaled into sampling pool 110.At the end of piston stroke, piston ring 121 moves to the position of thieff hatch 107 and is blocked, envelope
Close sampling pool 110.
The scheme of embodiment 1 need to guarantee stroke L2 phase of the centre distance L1 with piston 105 of piston 105 and piston ring 121
Deng, i.e. L1=L2, therefore embodiment 1 there are certain requirements the space layout of capsule.However this spline structure is more complete, and by
It is to be rigidly connected in piston 105 and piston ring 121, it is easier to guarantee sealing again for thief hatch 107.
A kind of sampling capsule with sampling pool sealing structure that embodiment 2 designs is substantially the same manner as Example 1, such as Fig. 3
Shown in 4, difference is, thieff hatch closeouts are O-shaped rubber ring 202, which passes through line 201 and piston 105
Connection, the O-shaped rubber ring 202 can block thieff hatch 107 under 111 the fully extended state of spring.
In embodiment 2, the inner wall of the O-shaped rubber ring 202 and capsule housing 101 is interference fit.
Under original state, piston 105 blocks thieff hatch 107；When the sensor in capsule sensing and control module 116 determines
After capsule reaches preset alimentary canal position, trigger signal is sent, heater 113 is started to work after being connected to trigger signal,
The heating head 115 of heater 113 reaches the easy fuse 114 that fuses after assigned temperature, thus release spring 111.Spring 111, which pushes, lives
Plug 105 squeezes medicine storehouse 104, sprays drug from release hole 102.At the same time, piston 105 leaves original position, and thieff hatch 107 is opened
It puts, starts to sample, piston 105 moves right, and decontrols thieff hatch 107 and pulls line 201；After sampling, piston 105 passes through line
O-shaped rubber ring 202 is pulled at thieff hatch 107 and is closed by 201.According to above-mentioned principle, length and the piston 105 of line 201
Stroke is equal.
The scheme of embodiment 2 connects piston 105 and rubber ring 202 with line 201, instead of rigid connection, reduces to capsule
The limitation of internal space layout keeps size design more flexible.However, the precision of installation, 105 stroke of piston is wanted in non-rigid connection
Ask higher.
A kind of sampling capsule system that embodiment 3 designs, as it can be seen in figures 5 and 6, sampling capsule system 301 includes capsule shells
Body 101, spring 111, waterproof jacket 306, arc-shaped piston 309, heater 113, capsule sensing and control module 116, spring branch
Pushing out ring 118, O shape piston 303, elastic waterproof layer 302 and meltable spring fastener, the outer ring of spring supporting ring 118 and capsule shells
101 inner wall of body is sealedly and fixedly connected, and the opening portion of the inner ring and waterproof jacket 306 of spring supporting ring 118 is sealedly and fixedly connected,
In, capsule housing 101 includes electric control element storehouse 120, sampling pool 110 and medicine storehouse 104, electric control element storehouse 120 and sampling pool 110 it
Between by spring supporting ring 118 and waterproof jacket 306 sealing separate, between sampling pool 110 and medicine storehouse 104 by arc-shaped piston 309 every
It opens, elastic water-proof film 307, O shape piston 303 and arc-shaped piston 309 is equipped between capsule housing 101 and arc-shaped piston 309
Open end be fixedly connected, the capsule housing 101, arc-shaped piston 309 and elastic water-proof film 307 surround medicine storehouse 104, capsule
Release hole 102 is offered on shell 101, which is sealed by sealing-plug, and arc-shaped piston 309 is equipped with and release hole
102 opposite intercommunicating pores, the intercommunicating pore are blocked that (rubber plug 308 can be inserted into syringe needle and be used for from sampling pool by rubber plug 308
Middle recycling sample, rubber plug 308 still seals sampling pool when syringe needle is extracted), capsule sensing and control module 116 are arranged in electricity
It controls in element storehouse 120, heater 113 is arranged in waterproof jacket 306, and spring 111 is arranged in spring supporting ring 118 and O shape piston
Between 303, one end of spring 111 is fixedly connected with spring supporting ring 118, and the other end of spring 111 connects O shape piston 303, bullet
111 sets of spring outside waterproof jacket 306, one end of elastic waterproof layer 302 is fixedly connected with spring supporting ring 118, elastic waterproof layer 302
The other end connect with O shape piston 303, elastic waterproof layer 302 is attached to 111 outer peripheral surface of spring, and sampling pool 110 is by arc-shaped work
Plug 309, waterproof jacket 306 and elastic waterproof layer 302 surround, and spring 111 is limited in compressive state by meltable spring fastener, heating
The heating head 115 of device 113 can be such that meltable spring fastener releases and compress to spring 111 by heating to meltable spring fastener
The fastening of state, radial through-hole 304 is opened up on O shape piston 303, and capsule housing 101 is equipped with thief hatch 305, O shape piston 303
Radial through-hole 304 in 111 compressive state of spring by capsule housing 101 inner wall block, the radial through-hole 304 is in spring
It can be connected to thief hatch 305 after 111 uncompressions, the radial through-hole 304 is after 111 full extension of spring by capsule housing 101
Inner wall block again, capsule sensing and control module 116 heating control signal output connection heater 113 control believe
Number input terminal.
In embodiment 3, the meltable spring fastener is easy fuse 114, open up on the spring supporting ring 118 there are two
Hole is blocked respectively by two the second rubber stoppers 117 on above-mentioned two hole, and one end of the easy fuse 114 passes through second rubber
Be fixedly connected after rubber plug 117 with O shape piston 303, the other end of easy fuse 114 pass through after another second rubber stopper 117 with O shape
Piston 303 is fixedly connected, and the heating head 115 of heater 113 is contacted with easy fuse 114.
In embodiment 3, when the sensor in capsule sensing and control module 116 determines that capsule reaches preset digestion
Behind road position, trigger signal is sent, heater 113 is started to work after being connected to trigger signal, and the heating head 115 of heater 113 reaches
Fuse easy fuse 114 after to assigned temperature, and spring 111 pushes arc-shaped piston 309 to move right, and drug is sprayed from release hole 102
Out, radial through-hole 304 is aligned with thief hatch 305, sucks external substance due to the low pressure in sampling pool.In arc-shaped piston
The stroke end of 309 and O shape piston 303, radial through-hole 304 are staggered with thief hatch 305 again, and sampling pool is closed.
The scheme of embodiment 3 is by opening up radial through-hole 304 on O shape piston 303, with the thief hatch on capsule housing 101
The mode of 305 cooperations is sampled, and the mode such as two kinds of pistons connection in embodiment 1,2 is eliminated.Therefore, space layout limits
System, installation are slightly lower with piston stroke required precision.However, the design is bigger to materials demand, such as elastic waterproof layer 302 and elasticity
Waterproof membrane 307.
A kind of sampling capsule with sampling pool sealing structure that embodiment 4 designs is substantially the same manner as Example 2, such as Fig. 7
Shown, difference is, the piston 105 be with the matched arc piston in 101 end of capsule housing, the end of arc piston is equipped with
Spring supporting platform 4, the spring supporting platform 4 of the other end connection piston 105 of spring 111.Arc piston and 101 inner wall of capsule housing
Interference fit.
The content that this specification is not described in detail belongs to the prior art well known to professional and technical personnel in the field.
Claims (10)
1. a kind of sampling capsule with sampling pool sealing structure, it is characterised in that：It includes capsule housing (101), piston
(105), spring (111), waterproof cover (112), heater (113), capsule sensing and control module (116), spring supporting ring
(118), thieff hatch closeouts and meltable spring fastener, the outer ring of spring supporting ring (118) and capsule housing (101) inner wall are close
Envelope is fixedly connected, and the opening portion of the inner ring and waterproof cover (112) of spring supporting ring (118) is sealedly and fixedly connected, wherein capsule shells
Body (101) includes electric control element storehouse (120), sampling pool (110) and medicine storehouse (104), electric control element storehouse (120) and sampling pool
(110) between by spring supporting ring (118) and waterproof cover (112) sealing separate, between sampling pool (110) and medicine storehouse (104) by
Piston (105) sealing separates, and release hole (102) are offered on capsule housing (101), which is sealed by sealing-plug,
The medicine storehouse sealing plate (119) in medicine storehouse (104) is equipped with the through-hole (103) that can be connected to release hole (102), and through-hole (103) uses
Oil sealing, capsule sensing and control module (116) are arranged in electric control element storehouse (120), and heater (113) is arranged in waterproof cover
(112) in, spring (111) is located in sampling pool (110), and one end of spring (111) is connect with spring supporting ring (118), spring
(111) the other end connects piston (105), and spring (111) is limited in compressive state, heater by meltable spring fastener
(113) heating head (115) can be such that meltable spring fastener releases to spring (111) by heating to meltable spring fastener
The fastening of compressive state, piston (105) are equipped with thieff hatch closeouts, and capsule housing (101) is equipped with thieff hatch (107), living
Plug (105) can be blocked thieff hatch (107) in spring (111) compressive state, and thieff hatch closeouts can stretch completely in spring (111)
It is blocked under exhibition state thieff hatch (107), thieff hatch (107) can be when piston (105) and thieff hatch closeouts not be blocked
It is connected to sampling pool (110), piston (105) is equipped with the intercommunicating pore that sampling pool (110) can be made to be connected to medicine storehouse (104), the company
Through-hole is blocked by the first rubber stopper (106), and the heating control signal output of capsule sensing and control module (116) connects heating
The control signal input of device (113).
2. the sampling capsule according to claim 1 with sampling pool sealing structure, it is characterised in that：The meltable spring
Fastener is easy fuse (114), is opened up on the spring supporting ring (118) there are two hole, respectively by two on above-mentioned two hole
Second rubber stopper (117) is blocked, and one end of the easy fuse (114) passes through second rubber stopper (117) and seals afterwards with thieff hatch
Blocking piece is fixedly connected, and the other end of easy fuse (114) passes through another second rubber stopper (117) and fixes afterwards with thieff hatch closeouts
Connection, the heating head (115) of heater (113) are contacted with easy fuse (114).
3. the sampling capsule according to claim 1 with sampling pool sealing structure, it is characterised in that：The meltable spring
Fastener is hot melt adhesive, and the heating head (115) of the heater (113) is contacted with hot melt adhesive.
4. the sampling capsule according to claim 1 or 2 or 3 with sampling pool sealing structure, it is characterised in that：It is described to adopt
Sample hole closeouts are piston ring (121), and piston ring (121) is fixedly connected by tubular connection piece (109) with piston (105), institute
Stating piston ring (121) can block thieff hatch (107) under spring (111) the fully extended state, the side wall of tubular connection piece (109)
It is equipped with the intermediate channel (108) for being connected to thieff hatch (107) and sampling pool (110).
5. the sampling capsule according to claim 1 with sampling pool sealing structure, it is characterised in that：The thieff hatch envelope
Blocking piece is O-shaped rubber ring (202), which is connect by line (201) with piston (105), the O-shaped rubber ring
(202) thieff hatch (107) can be blocked under spring (111) the fully extended state.
6. the sampling capsule according to claim 5 with sampling pool sealing structure, it is characterised in that：The piston
(105) to be equipped with spring supporting platform (4) with the end of the matched arc piston in capsule housing (101) end, arc piston, spring
(111) the spring supporting platform (4) of other end connection piston (105).
7. the sampling capsule according to claim 4 with sampling pool sealing structure, it is characterised in that：The piston
It (105) is interference fit with the inner wall of capsule housing (101), the piston ring (121) and the inner wall of capsule housing (101) were
It is full of cooperation.
8. the sampling capsule according to claim 5 with sampling pool sealing structure, it is characterised in that：The O-shaped rubber
The inner wall for enclosing (202) and capsule housing (101) is interference fit.
9. a kind of sampling capsule system, it is characterised in that：Sampling capsule system (301) includes capsule housing (101), spring
(111), waterproof jacket (306), arc-shaped piston (309), heater (113), capsule sensing and control module (116), spring branch
Pushing out ring (118), O shape piston (303), elastic waterproof layer (302) and meltable spring fastener, the outer ring of spring supporting ring (118)
It is sealedly and fixedly connected with capsule housing (101) inner wall, the opening portion of the inner ring and waterproof jacket (306) of spring supporting ring (118) is close
Envelope is fixedly connected, wherein capsule housing (101) includes electric control element storehouse (120), sampling pool (110) and medicine storehouse (104), automatically controlled
It is separated between element storehouse (120) and sampling pool (110) by spring supporting ring (118) and waterproof jacket (306) sealing, sampling pool
(110) it is separated between medicine storehouse (104) by arc-shaped piston (309), between capsule housing (101) and arc-shaped piston (309)
Equipped with elastic water-proof film (307), O shape piston (303) is fixedly connected with the open end of arc-shaped piston (309), the capsule shells
Body (101), arc-shaped piston (309) and elastic water-proof film (307) surround medicine storehouse (104), offer and release on capsule housing (101)
Medicine hole (102), the release hole (102) are sealed by sealing-plug, and arc-shaped piston (309) is equipped with opposite with release hole (102)
Intercommunicating pore, the intercommunicating pore are blocked by rubber plug (308), and capsule sensing and control module (116) are arranged in electric control element storehouse
(120) in, in waterproof jacket (306), spring (111) setting is living in spring supporting ring (118) and O shape for heater (113) setting
It fills between (303), one end of spring (111) is fixedly connected with spring supporting ring (118), and the other end of spring (111) connects O shape
Piston (303), spring (111) cover waterproof jacket (306) outside, one end of elastic waterproof layer (302) and spring supporting ring (118) are solid
Fixed connection, the other end of elastic waterproof layer (302) are connect with O shape piston (303), and elastic waterproof layer (302) is attached to spring (111)
Outer peripheral surface, sampling pool (110) are surrounded by arc-shaped piston (309), waterproof jacket (306) and elastic waterproof layer (302), spring
(111) compressive state is limited in by meltable spring fastener, the heating head (115) of heater (113) can be by meltable spring
Fastener heating makes meltable spring fastener release the fastening to spring (111) compressive state, opens up diameter on O shape piston (303)
To through-hole (304), capsule housing (101) is equipped with thief hatch (305), and the radial through-hole (304) of O shape piston (303) is in spring
(111) it is blocked when compressive state by the inner wall of capsule housing (101), the radial through-hole (304) is after spring (111) uncompression
It can be connected to thief hatch (305), the radial through-hole (304) is after spring (111) full extension by the inner wall of capsule housing (101)
It blocks again, the control signal of heating control signal output connection heater (113) of capsule sensing and control module (116)
Input terminal.
10. sampling capsule system according to claim 1, it is characterised in that：The meltable spring fastener is easy fuse
(114), it is opened up on the spring supporting ring (118) there are two hole, respectively by two the second rubber stoppers (117) on above-mentioned two hole
It blocks, one end of the easy fuse (114) passes through second rubber stopper (117) and is fixedly connected afterwards with O shape piston (303), easily
The other end of fuse (114) passes through another second rubber stopper (117) and is fixedly connected afterwards with O shape piston (303), heater
(113) heating head (115) is contacted with easy fuse (114).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810617882.4A CN108836237A (en) | 2018-06-15 | 2018-06-15 | A kind of sampling capsule with sampling pool sealing structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810617882.4A CN108836237A (en) | 2018-06-15 | 2018-06-15 | A kind of sampling capsule with sampling pool sealing structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108836237A true CN108836237A (en) | 2018-11-20 |
Family
ID=64202572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810617882.4A Pending CN108836237A (en) | 2018-06-15 | 2018-06-15 | A kind of sampling capsule with sampling pool sealing structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108836237A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497917A (en) * | 2019-01-11 | 2019-03-22 | 安翰科技(武汉)股份有限公司 | Alimentary canal sampling capsule |
| CN111973136A (en) * | 2020-09-14 | 2020-11-24 | 上海安翰医疗技术有限公司 | Control method and control system of magnetic control capsule endoscope device |
| WO2021017791A1 (en) * | 2019-07-26 | 2021-02-04 | 温州芳植生物科技有限公司 | Gastrointestinal tract sampling and drug releasing capsule |
| CN113329777A (en) * | 2019-02-01 | 2021-08-31 | 诺和诺德股份有限公司 | Medical device with actuation mechanism |
| CN113769250A (en) * | 2021-09-10 | 2021-12-10 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
| WO2022034041A1 (en) * | 2020-08-10 | 2022-02-17 | Massachusetts Institute Of Technology | Drug delivery device |
| WO2022069606A1 (en) * | 2020-09-30 | 2022-04-07 | Novo Nordisk A/S | A swallowable capsule device |
| US11369574B2 (en) | 2017-05-17 | 2022-06-28 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11541016B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0430535U (en) * | 1990-07-06 | 1992-03-11 | ||
| CN1422595A (en) * | 2002-12-27 | 2003-06-11 | 重庆大学 | Alimentary canal medical system capable of swallowing |
| CN2605868Y (en) * | 2003-01-24 | 2004-03-10 | 陈为民 | Miniature digestive canal sampler |
| CN1820798A (en) * | 2006-01-28 | 2006-08-23 | 重庆大学 | Capsule type digestive tract medicine releasing and sampling device |
| CN201719267U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Alimentary canal body fluid micro-collecting device |
| WO2018050647A1 (en) * | 2016-09-15 | 2018-03-22 | Stoco 10 GmbH | Fluid sampling device |
| CN209153588U (en) * | 2018-06-15 | 2019-07-26 | 安翰科技(武汉)股份有限公司 | A kind of sampling capsule with sampling pool sealing structure and a kind of sampling capsule system |
-
2018
- 2018-06-15 CN CN201810617882.4A patent/CN108836237A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0430535U (en) * | 1990-07-06 | 1992-03-11 | ||
| CN1422595A (en) * | 2002-12-27 | 2003-06-11 | 重庆大学 | Alimentary canal medical system capable of swallowing |
| CN2605868Y (en) * | 2003-01-24 | 2004-03-10 | 陈为民 | Miniature digestive canal sampler |
| CN1820798A (en) * | 2006-01-28 | 2006-08-23 | 重庆大学 | Capsule type digestive tract medicine releasing and sampling device |
| CN201719267U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Alimentary canal body fluid micro-collecting device |
| WO2018050647A1 (en) * | 2016-09-15 | 2018-03-22 | Stoco 10 GmbH | Fluid sampling device |
| CN209153588U (en) * | 2018-06-15 | 2019-07-26 | 安翰科技(武汉)股份有限公司 | A kind of sampling capsule with sampling pool sealing structure and a kind of sampling capsule system |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11369574B2 (en) | 2017-05-17 | 2022-06-28 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11712421B2 (en) | 2017-05-17 | 2023-08-01 | Massachusetts Institute Of Technology | Self-actuating articles |
| US11607390B2 (en) | 2017-05-17 | 2023-03-21 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11541016B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| CN109497917A (en) * | 2019-01-11 | 2019-03-22 | 安翰科技(武汉)股份有限公司 | Alimentary canal sampling capsule |
| CN113329777A (en) * | 2019-02-01 | 2021-08-31 | 诺和诺德股份有限公司 | Medical device with actuation mechanism |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
| CN113329777B (en) * | 2019-02-01 | 2024-01-09 | 诺和诺德股份有限公司 | Medical device with actuation mechanism |
| WO2021017791A1 (en) * | 2019-07-26 | 2021-02-04 | 温州芳植生物科技有限公司 | Gastrointestinal tract sampling and drug releasing capsule |
| WO2022034041A1 (en) * | 2020-08-10 | 2022-02-17 | Massachusetts Institute Of Technology | Drug delivery device |
| CN111973136A (en) * | 2020-09-14 | 2020-11-24 | 上海安翰医疗技术有限公司 | Control method and control system of magnetic control capsule endoscope device |
| WO2022069606A1 (en) * | 2020-09-30 | 2022-04-07 | Novo Nordisk A/S | A swallowable capsule device |
| CN113769250A (en) * | 2021-09-10 | 2021-12-10 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
| CN113769250B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108836237A (en) | A kind of sampling capsule with sampling pool sealing structure | |
| CN209153588U (en) | A kind of sampling capsule with sampling pool sealing structure and a kind of sampling capsule system | |
| CN100376299C (en) | Chemical reaction gas pressure type microcapsule medicine release method and apparatus thereof | |
| CN109330627A (en) | The capsule system for sampling and releasing the drug can either synchronously or asynchronously be completed | |
| CN100482293C (en) | Slow release type remote controlled electronic capsule | |
| CN108784634A (en) | Can automatic-sealed sampling capsule endoscope | |
| CN1820798A (en) | Capsule type digestive tract medicine releasing and sampling device | |
| JP2007160008A (en) | Implement to be introduced into subject | |
| ES2847215T3 (en) | Drug delivery device with pneumatic feeding unit | |
| EP0460327B1 (en) | Medical capsule and apparatus for activating the same | |
| JP7004704B2 (en) | Device for sampling gastrointestinal substances | |
| US11931013B2 (en) | Device for taking an intestinal sample | |
| CN208892526U (en) | A kind of enteron aisle microcapsule robot with application function | |
| EP2464413B1 (en) | Medicine reservoir for drug delivery device | |
| CN101690834A (en) | Continuous needleless injection system driven by electromagnetic force | |
| CN109497917A (en) | Alimentary canal sampling capsule | |
| CN208973791U (en) | Can automatic-sealed sampling capsule endoscope | |
| CN106730284A (en) | Microcapsules formula gastrointestinal drug discharges system | |
| CN100588378C (en) | Alimentary tract drug release remote controlled capsule system | |
| CN108956206A (en) | Sampling system based on needle tubing and vacuum technique | |
| CN209074527U (en) | Sampling capsule endoscope based on shape memory spring | |
| CN113769250B (en) | Drug delivery capsule | |
| CN107550536B (en) | Gynecological hemostatic device | |
| CN209678461U (en) | Alimentary canal sampling capsule | |
| JPH0713715Y2 (en) | Medical capsule |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 430075 666 new high tech Avenue, East Lake New Technology Development Zone, Wuhan, Hubei Applicant after: Anhan Science and Technology (Wuhan) Co., Ltd. Address before: 430075 666 new high tech Avenue, East Lake New Technology Development Zone, Wuhan, Hubei Applicant before: Ankon Photoelectric Technology (Wuhan) Co., Ltd. |
|
| CB02 | Change of applicant information |