CN108815495A - A kind of Chinese medicinal granule for treating ulcerative colitis - Google Patents
A kind of Chinese medicinal granule for treating ulcerative colitis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The present invention relates to the Chinese medicinal granules for the treatment of ulcerative colitis, the treatment safety, good effect, medication at low cost of ulcerative colitis can be effectively solved the problems, such as, by poidometer：10-14 grams of stir-baked RHIZOMA DIOSCOREAE, 10-14 grams of semen coicis, 10-14 grams of Poria cocos, 5-7 grams of coloured malt, 5-7 grams of stir-baked FRUCTUS CRATAEGI, 7-11 grams of purslane, 5-7 grams of Radix Paeoniae Alba, fry 7-11 grams of Semen Lablab Album, 5-7 grams of dark plum, 5-7 grams of rhizoma zingiberis, 5-7 grams of radix glycyrrhizae preparata, 7-11 grams of dried orange peel, 7-11 grams of honeysuckle and cortex cinnamomi 4-6 restrain into Chinese medicinal granule, compatibility of the present invention is scientific and reasonable, abundant raw material, preparation easy to produce, it is at low cost, it is convenient to take, effect is good, with activating microcirculation and removing stasis medicinal, anti-inflammatory analgetic, it removes necrosis and promote granulation, astringency inducing, the effect of antidiarrheal, effective for treating ulcerative colitis, it is the innovation treated on ulcerative colitis drug, there is significant economic and social benefit.
Description
Technical field
The present invention relates to medicine, especially a kind of Chinese medicinal granule for treating ulcerative colitis（Also known as tie Chang Fu Kang
Grain）.
Background technique
Ulcerative colitis is a kind of nonspecific inflammatory disease, and lesion locations are mainly mucous membrane and its lower layer.In recent years
To cause this sick disease incidence to go up year by year due to fast-developing bring environmental pollution of society etc. and other many factors.In
Doctor's ulcerative colitis belongs to scopes such as " chronic diarrhea " " protracted dysenteries ", and mainly by the excessive heresy of exogenous disease, the conditions such as diet is unbalance lead to the qi and blood stasis of blood
Stagnant, suppuration.Ulcerative colitis easily causes complication, and with diseases such as abdomen pain, diarrhea, hematochezias.Though existing have treatment ulcer
Property colitis drug, including Western medicine and Chinese medicine, but for various reasons, using and curative effect and unsatisfactory, therefore, treatment
Improvement and innovation on ulcerative colitis drug is imperative.
Summary of the invention
For above situation, for the defect for overcoming the prior art, the purpose of the present invention be just to provide it is a kind of treat it is exedens
The Chinese medicinal granule of colitis can effectively solve the problems, such as the treatment safety, good effect, medication at low cost of ulcerative colitis.
The technical solution that the present invention solves is that a kind of Chinese medicinal granule for treating ulcerative colitis, is by poidometer：It fries
It is 10-14 grams of Chinese yam, 10-14 grams of semen coicis, 10-14 grams of Poria cocos, 5-7 grams of coloured malt, 5-7 grams of stir-baked FRUCTUS CRATAEGI, 7-11 grams of purslane, white
5-7 grams of Chinese herbaceous peony fries 7-11 grams of Semen Lablab Album, 5-7 grams of dark plum, 5-7 grams of rhizoma zingiberis, 5-7 grams of radix glycyrrhizae preparata, 7-11 grams of dried orange peel, honeysuckle 7-11
Gram and cortex cinnamomi 4-6 restrain at, wherein by stir-baked RHIZOMA DIOSCOREAE, coloured malt, stir-baked FRUCTUS CRATAEGI, fry Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into
The traditional Chinese medicine fine powder of 80 meshes, residual drug decocting are extracted twice, are added the water of 8 times of residual drug weight for the first time, are impregnated 30 minutes,
It is boiled by fire, turns small fire and decoct 30 minutes, filtering obtains first time decocting liquid, the dregs of a decoction add the water of 6 times of weight of residual drug again, greatly
Fire is boiled, and is turned small fire and is decocted 30 minutes, and filtering obtains second of decocting liquid, merges decocting liquid twice, and spray drying is thin with Chinese medicine
Powder mixes, and Chinese medicinal granule is made.
Compatibility of the present invention is scientific and reasonable, abundant raw material, preparation easy to produce, at low cost, convenient to take, effect is good, has and mends
The effect of middle gas, excreting dampness is turbid, and promoting the circulation of qi is stagnant, clear stagnant heat, makes the strong fortune of temper, and damp and hot, ecchymosis so evil that go, then all diseases are from removing, effectively
For treating ulcerative colitis, it is the innovation treated on ulcerative colitis drug, there is significant economic and social benefit.
Specific embodiment
It elaborates below in conjunction with concrete condition and embodiment to a specific embodiment of the invention.
The present invention in specific implementation, can be provided by following embodiment.
Embodiment 1
In specific implementation, a kind of Chinese medicinal granule for treating ulcerative colitis, is by poidometer to the present invention：Stir-baked RHIZOMA DIOSCOREAE 12
Gram, 12 grams of semen coicis, 12 grams of Poria cocos, 6 grams of coloured malt, 6 grams of stir-baked FRUCTUS CRATAEGI, 9 grams of purslane, 6 grams of Radix Paeoniae Alba, fry 9 grams of Semen Lablab Album, dark plum
6 grams, 6 grams of rhizoma zingiberis, 6 grams of radix glycyrrhizae preparata, 9 grams of dried orange peel, 9 grams of honeysuckle and cortex cinnamomi 5 restrain at, wherein by stir-baked RHIZOMA DIOSCOREAE, coloured malt, stir-fry
Hawthorn fries the traditional Chinese medicine fine powder that Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into 80 meshes, and residual drug decocting is extracted twice, the
Once plus the water of 8 times of residual drug weight, immersion 30 minutes are boiled by fire, and turn small fire and decoct 30 minutes, filtering obtains for the first time
Decocting liquid, the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turn small fire and decoct 30 minutes, and filtering obtains second of water
Decocting liquid, merges decocting liquid twice, and spray drying mixes with traditional Chinese medicine fine powder, Chinese medicinal granule is made.
Embodiment 2
In specific implementation, a kind of Chinese medicinal granule for treating ulcerative colitis, is by poidometer to the present invention：Stir-baked RHIZOMA DIOSCOREAE 11
Gram, 13 grams of semen coicis, 11 grams of Poria cocos, 6.5 grams of coloured malt, 5.5 grams of stir-baked FRUCTUS CRATAEGI, 8 grams of purslane, 6.5 grams of Radix Paeoniae Alba, fry Semen Lablab Album 8
Gram, 6.5 grams of dark plum, 5.5 grams of rhizoma zingiberis, 6.5 grams of radix glycyrrhizae preparata, 8 grams of dried orange peel, 10 grams of honeysuckle and cortex cinnamomi 4.5 restrain at, wherein will
Stir-baked RHIZOMA DIOSCOREAE, stir-baked FRUCTUS CRATAEGI, fries the traditional Chinese medicine fine powder that Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into 80 meshes, residual drug at coloured malt
Decocting is extracted twice, and for the first time plus the water of 8 times of residual drug weight, immersion 30 minutes are boiled by fire, and is turned small fire and is decocted 30 points
Clock, filtering, obtains first time decocting liquid, and the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turns small fire and decocts 30 minutes,
Filtering obtains second of decocting liquid, merges decocting liquid twice, and spray drying mixes with traditional Chinese medicine fine powder, Chinese medicinal granule is made.
Embodiment 3
In specific implementation, a kind of Chinese medicinal granule for treating ulcerative colitis, is by poidometer to the present invention：Stir-baked RHIZOMA DIOSCOREAE 13
Gram, 11 grams of semen coicis, 13 grams of Poria cocos, 5.5 grams of coloured malt, 6.5 grams of stir-baked FRUCTUS CRATAEGI, 10 grams of purslane, 5.5 grams of Radix Paeoniae Alba, fry Semen Lablab Album
10 grams, 5.5 grams of dark plum, 6.5 grams of rhizoma zingiberis, 5.5 grams of radix glycyrrhizae preparata, 10 grams of dried orange peel, 8 grams of honeysuckle and cortex cinnamomi 5.5 restrain at, wherein
Stir-baked RHIZOMA DIOSCOREAE, coloured malt, stir-baked FRUCTUS CRATAEGI, stir-fry Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into the traditional Chinese medicine fine powder of 80 meshes, remaining medicine
Object decocting is extracted twice, and for the first time plus the water of 8 times of residual drug weight, immersion 30 minutes are boiled by fire, and is turned small fire and is decocted 30 points
Clock, filtering, obtains first time decocting liquid, and the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turns small fire and decocts 30 minutes,
Filtering obtains second of decocting liquid, merges decocting liquid twice, and spray drying mixes with traditional Chinese medicine fine powder, Chinese medicinal granule is made.
The effect of said components support there is bowl spares gas mutually, and excreting dampness is turbid, and promoting the circulation of qi is stagnant, clear stagnant heat makes the strong fortune of temper, wet
Heat, ecchymosis it is so evil that go, then all diseases are from removing, and effective for treating ulcerative colitis, and achieve and extraordinary have through experiment
Beneficial technical effect, related testing data are as follows：
One, zoopery
1. material
1.1 reagents and drug
Glacial acetic acid, the production of Tianjin Heng Xing chemical reagent Manufacturing Co., Ltd, lot number 20171006；Physiological saline, Henan Cologne medicine
The production of industry Co., Ltd, lot number N17021703-1；Pill for strengthening spleen and intestines, Guangzhou Baiyunshan Chenliji Pharmaceutical Factory Co., Ltd.'s production, batch
Number H05027；Chinese medicinal granule of the present invention（Also known as colon answers recovering particles）, 5 grams every bag, 3 times a day, 1-2 bags each.
1.2 laboratory apparatus
Ultraviolet lamp, Beijing Zhong Yifuteng Science and Technology Ltd.；Power 30W, wavelength 303nm；HWS12 type electric-heated thermostatic water bath,
Shanghai Yiheng Scientific Instruments Co., Ltd；KDC-160HR high speed freezing centrifuge, good point of public affairs in Keda Innovation Co., Ltd
Department；680 type microplate reader, BIO-RAD company of the U.S.；Adjustable pipette, Shanghai Lei Bo Analytical Instrument Co., Ltd；DHG-
9038A electric heating constant-temperature blowing drying box, the upper macro experimental facilities Co., Ltd of Nereid.
1.3 experimental animal
SD rat, grade：SPF, 60 male, weight 200-220g is provided by Zhengzhou University's animal experimental center, the animal quality certification
Number 41003100005060.
2. experimental method
2.1 modelings, 6% glacial acetic acid bowel lavage modeling, Rat Fast can't help water for 24 hours before modeling, the polyvinyl chloride for being 2mm with diameter
Pipe is inserted into 8cm in rat anus, and in addition to blank group saline injection 1mL, other groups inject 6% glacial acetic acid 1mL, accurate fixed
When 20s after, with 5mL normal saline flushing.Model is successfully established after modeling three days.After modeling success, rat whole diarrhea, spirit
Bad, activity is slow, and weight is declined slightly.
The successful rat of modeling is randomly divided into 5 groups by 2.2 administrations, respectively：Model group, pill for strengthening spleen and intestines group（3g/
kg）, that colon answers recovering particles is big（1.25g/kg）, in（2.5g/kg）, it is small（5g/kg）Dosage group, after modeling success, by corresponding
Dosage carries out stomach-filling.12d is administered, observes excrement situation in last dose fasting 12h abdominal aortic blood and surveys IL- in its serum
6（Interleukin-6）,TNF-α（Tumor necrosis factor）Content, colonic tissue homogenate in EGF（Epidermal growth factor）,SOD
（Superoxide dismutase）,MDA（Malonaldehyde）Content.Take spleen thymus gland and colonic pathological change position.Colon portion homogenate, it is remaining
It places formalin solution to fix, it is spare to do pathological section.
Rat blood and homogenate are centrifuged 10min with 3000 revs/min of speed by 2.3 Indexs measures.Its supernatant is taken,
- 40 DEG C are set to save backup.
2.4 statistical method experimental datas with SPSS21.0 statistical software handle, data with (± s) it indicates, comparison among groups
It is examined using t.
Experimental result
The influence of 3.1 pairs of rats with ulcerative colitis diarrhea situations
1 colon of table answers the influence that recovering particles cause rats with ulcerative colitis diarrhea to 6% glacial acetic acid
| Group | Dosage（g/kg） | N | - | + | ++ | +++ | P |
| Blank group | 10 | 10 | 0 | 0 | 0 | ** | |
| Model group | 10 | 1 | 2 | 6 | 1 | ||
| Pill for strengthening spleen and intestines group | 3 | 10 | 5 | 3 | 2 | 0 | * |
| Colon answers recovering particles small dose group | 1.25 | 10 | 3 | 3 | 4 | 0 | |
| Colon answers recovering particles middle dose group | 2.5 | 10 | 6 | 2 | 2 | 0 | ** |
| Colon answers recovering particles large dosage group | 5 | 10 | 7 | 2 | 1 | 0 | ** |
Note：* is p<0.01, * p<0.05 -:To be normal, no diarrhea situation；+:Stool forming, it is softer；++：It defecates shapeless
；+++：It defecates shapeless, it is diluter
It is obtained through ridit inspection：Compared to the blank group, the significant diarrhea of model group（p<0.01）, illustrate modeling success.With mould
Type group is compared, and colon answers that recovering particles are big, middle dose group can significantly improve diarrhea（p<0.01）, colon answers recovering particles large dosage group only
Has the tendency that alleviating diarrhoea（p>0.05）, pill for strengthening spleen and intestines group can make diarrhea be improved significantly（p<0.05）.
The influence of EGF, MDA content in 3.2 pairs of rats with ulcerative colitis colonic tissues
Table 2 answers recovering particles to colon and causes EGF, MDA content in rats with ulcerative colitis colonic tissue to 6% glacial acetic acid
Influence (±s)
| Group | N | EGF（pg/mL） | MDA（nmol/ml） |
| Blank group | 10 | 299.17±15.88** | 1.43±0.14** |
| Model group | 10 | 329.17±24.13 | 1.71±0.22 |
| Pill for strengthening spleen and intestines group | 10 | 308.33±18.52* | 1.53±0.07* |
| Colon answers recovering particles small dose group | 10 | 310.56±40.5 | 1.58±0.09 |
| Colon answers recovering particles middle dose group | 10 | 301.53±16.52** | 1.51±0.13* |
| Colon answers recovering particles large dosage group | 10 | 294.86±14.46** | 1.49±0.1** |
Note：* is p<0.01, * p<0.05
Compared to the blank group, EGF, MDA content significantly increase in model group rats colonic tissue（p<0.01）, illustrate modeling at
Function.Compared with model group, colon answers that recovering particles are big, containing for EGF in rat model colonic tissue can be significantly reduced in middle dose group
Amount（p<0.01）, colon, which answers recovering particles large dosage group, can be significantly reduced the content of MDA in rat model colonic tissue（p<
0.01）, colon answer the content that recovering particles middle dose group can be substantially reduced MDA in rat model colonic tissue（p<0.05）, knot
Chang Fu Kang particle small dose group has the tendency that reducing EGF, MDA content in colonic tissue（p>0.05）；Pill for strengthening spleen and intestines group can be bright
The aobvious content for reducing EGF, MDA in rat colon tissue is equal（p<0.05）.
The influence of the activity and TNF-α, IL-6 content of SOD in 3.3 pairs of rats with ulcerative colitis serum
3 colon of table answers recovering particles and causes SOD, TNF-α, IL-6 content in rats with ulcerative colitis serum to 6% glacial acetic acid
Influence (±s)
| Group | N | Dosage | SOD（U/mL） | TNF-α（pg/mL） | IL-6（pg/mL） |
| Blank group | 10 | 46.41±6.63** | 37.68±3.33** | 22.81±4.13** | |
| Model group | 10 | 28.41±3.49 | 43.9±6.96 | 45.62±8.73 | |
| Pill for strengthening spleen and intestines group | 10 | 3g/kg | 38.74±5.73** | 37.5±3.92* | 33.04±5.18** |
| Colon answers recovering particles small dose group | 10 | 1.25g/kg | 29.88±4.29 | 39.27±8.44 | 41.31±3.12 |
| Colon answers recovering particles middle dose group | 10 | 2.5g/kg | 39.57±4.42** | 38.9±2.23* | 29.71±4.79** |
| Colon answers recovering particles large dosage group | 10 | 5g/kg | 42.41±7.68** | 36.4±3.98** | 26.34±4.65** |
Note：* is p<0.01, * p<0.05
Compared to the blank group, SOD activity significantly reduces in model group serum（p<0.01）, TNF-α, IL-6 content significantly increase（p
<0.01）Illustrate modeling success.Compared with model group, colon answers recovering particles large dosage group can significant elevation model rat blood serum SOD
Activity（p<0.01）, significantly reduce rat model Serum TNF-α, IL-6 content（p<0.01）；Colon answers recovering particles middle dose group
It can significant elevation model rat blood serum SOD activity with pill for strengthening spleen and intestines group（p<0.01）, significantly reduce rat model blood serum IL-6
Content（p<0.01）, be substantially reduced rat model Serum TNF-α content（p<0.01）；Colon answers recovering particles small dose group to rat
Activity of SOD in serum and Serum TNF-α, IL-6 content only have adjustment trend（p>0.05）.
The influence of 3.4 pairs of rats with ulcerative colitis index and spleen index
4 colon of table answer recovering particles to 6% glacial acetic acid cause rats with ulcerative colitis index and spleen index influence (±s)
| Group | N | Dosage | Weight（g） | Index and spleen index |
| Blank group | 10 | 330.17±6.5 | 2.77±0.53** | |
| Model group | 10 | 258.68±12.24 | 3.94±0.7 | |
| Pill for strengthening spleen and intestines group | 10 | 3g/kg | 296.14±6.28 | 3.11±0.43** |
| Colon answers recovering particles small dose group | 10 | 1.25g/kg | 272.46±6.8 | 3.91±0.38 |
| Colon answers recovering particles middle dose group | 10 | 2.5g/kg | 297.54±4.09 | 3.7±0.51 |
| Colon answers recovering particles large dosage group | 10 | 5g/kg | 312.58±5.09 | 2.77±0.48** |
Note：* is p<0.01, * p<0.05
Compared to the blank group, model group index and spleen index significantly increases（p<0.01）, illustrate modeling success.Compared with model group, knot
Chang Fu Kang particle large dosage group and pill for strengthening spleen and intestines group can be such that rat model index and spleen index significantly reduces, colon answers in recovering particles,
Small dose group has the tendency that reducing index and spleen index（p>0.05）.
The influence of 3.5 pairs of rats with ulcerative colitis spleens, colonic tissue form
3.5.1 the influence of rats with ulcerative colitis spleen tissue form is caused to 6% glacial acetic acid
Blank group Rats Spleen structure is normal, and periarterial lymphatic sheath, acini lienalis and side is distributed in white pulp around central artery
Edge area.Lymph sheath and acini lienalis are mainly made of lymphocyte, and arrangement is loose, and marginal zone is mainly by macrophage and lymphocyte
It constitutes；Red pulp is mainly made of splenic cords and splenic sinusoid, by lymphocyte, thick liquid cell, macrophage, Dendritic Cells and red blood cell
It constitutes, arrangement is loose, has no pathological change.See that white pulp acini lienalis quantity increased significantly under model group rats spleen mirror, volume increases
Greatly, average diameter 380um, lymphocyte dense arrangement.Red pulp splenic cords and splenic sinusoid lymphocyte increase with macrophage, may
For caused by immune response, some cases spleen extravasated blood.Pill for strengthening spleen and intestines group Rats Spleen structure is normal, and white pulp is along center
Periarterial lymphatic sheath, acini lienalis and marginal zone is distributed in periarterial；Lymph sheath and acini lienalis are mainly made of lymphocyte,
But quantity increased significantly compared to the blank group；Red pulp is mainly made of splenic cords and splenic sinusoid, by lymphocyte, thick liquid cell, macrophage
Cell, Dendritic Cells and red blood cell are constituted, and lymphocyte accounting is larger, occurs spleen extravasated blood individually.Large dosage knot Chang Fu Kang
Grain group Rats Spleen Splenic structure is normal, and periarterial lymphatic sheath, acini lienalis and edge is distributed in white pulp around central artery
Area；Lymph sheath and acini lienalis are mainly made of lymphocyte, and marginal zone is mainly made of macrophage and lymphocyte；Red pulp master
It to be made of splenic cords and splenic sinusoid, be made of lymphocyte, thick liquid cell, macrophage, Dendritic Cells and red blood cell, have no disease
Reason changes.Middle dosage colon answers that recovering particles group Rats Spleen structure is normal, and periarterial is distributed in white pulp around central artery
Lymph sheath, acini lienalis and marginal zone；Lymph sheath and acini lienalis are mainly made of sparse lymphocyte, and marginal zone is mainly by macrophage
Cell and lymphocyte are constituted；Red pulp is mainly made of splenic cords and splenic sinusoid, by lymphocyte, thick liquid cell, macrophage, dendron
Shape cell and red blood cell are constituted, and quantity is substantially close with blank group, have no obvious pathological change.Low dose of colon answers recovering particles group
See that white pulp acini lienalis quantity increased significantly under Rats Spleen mirror, volume increases, average diameter 380um, lymphocyte dense arrangement；
Red pulp splenic cords and splenic sinusoid lymphocyte increase with macrophage, and macrophage proliferation is obvious, and each high power field is about 5,
Most of is multicore, may be some cases spleen extravasated blood caused by immune response.
5 colon of table answers the influence that recovering particles cause rats with ulcerative colitis spleen tissue form to 6% glacial acetic acid
| Group | N | - | + | ++ | +++ | P |
| Blank group | 10 | 10 | 0 | 0 | 0 | ** |
| Model group | 10 | 1 | 3 | 6 | 0 | |
| Pill for strengthening spleen and intestines group | 10 | 6 | 2 | 2 | 0 | * |
| Colon answers recovering particles small dose group | 10 | 3 | 4 | 3 | 0 | |
| Colon answers recovering particles middle dose group | 10 | 4 | 5 | 1 | 0 | * |
| Colon answers recovering particles large dosage group | 10 | 7 | 3 | 0 | 0 | ** |
Note：* is p<0.01, * p<0.05
-：Splenic structure is normal, level marshalling；+：Splenic structure is normal, and lymph sheath and acini lienalis are mainly thin by lymph
Born of the same parents' quantity slightly increases；++：Spleen white pulp acini lienalis quantity increases, and lymph sheath and acini lienalis are mainly increased by lymphocyte quantity
It is more；
+++：Spleen white pulp acini lienalis quantity increased significantly, and volume increases, spleen cell increases, macrophage increases, red pulp spleen
Rope and splenic sinusoid lymphocyte increase with macrophage.
It is obtained through ridit inspection, compared to the blank group, significant pathological change occurs in model group spleen tissue（p<0.01）,
Illustrate modeling success.Compared with model group, colon, which answers recovering particles large dosage group, can significantly improve Ulcerative Colitis Model spleen
Dirty tissue morphology（p<0.01）；Colon answers recovering particles middle dose group and pill for strengthening spleen and intestines group is obviously improved Ulcerative Colitis Model
The tissue morphology of spleen（p<0.05）；Colon, which answers recovering particles small dose group, then only improves Ulcerative Colitis Model spleen tissue
Form（p>0.05）.
3.5.2 the influence of rats with ulcerative colitis colonic tissue form is caused to 6% glacial acetic acid
Blank group Colonic Mucosa of The Rat is coated simple columnar epithelium, body of gland marshalling, it is seen that a large amount of goblet cells, it is even under mucous membrane
See lymph nodule, a little inflammatory cell infiltration of mucous layer.Model group：Ulcer is formed, and mucous membrane lacks such as, it is seen that necrotic tissue, bleeding,
Inflammatory cell infiltration, granulation tissue, ulcer edge mucous epithelium hyperplasia.Pill for strengthening spleen and intestines group Colonic Mucosa of The Rat is coated single layer column
Columnar epithelium, body of gland marshalling, it is seen that a large amount of goblet cells, accidental lymph nodule under mucous membrane, a little lymphocyte leaching of mucous layer
Profit.Large dosage of colon answers recovering particles group Colonic Mucosa of The Rat and is coated simple columnar epithelium, body of gland marshalling, it is seen that a large amount of cup-shapeds
Cell, accidental lymph nodule under mucous membrane, mucous layer mild inflammatory cellular infiltration.Middle dosage colon answers recovering particles group rat ulcer shape
At mucous membrane lacks such as, it is seen that necrotic tissue, bleeding, inflammatory cell infiltration, granulation tissue, ulcer edge mucous epithelium active proliferation,
Consider atypical hyperplasia.Low dose of colon is answered recovering particles group rat colon ulcer and is formed, and mucous membrane lacks such as, it is seen that necrotic tissue, out
Blood, massive inflammatory cells infiltrated, granulation tissue, ulcer edge mucous epithelium hyperplasia, and see nuclear fission, consider atypical hyperplasia.
6 colon of table answers the influence that recovering particles cause rats with ulcerative colitis colonic tissue form to 6% glacial acetic acid
| Group | N | - | + | ++ | +++ | P |
| Blank group | 10 | 10 | 0 | 0 | 0 | ** |
| Model group | 10 | 0 | 3 | 7 | 0 | |
| Pill for strengthening spleen and intestines group | 10 | 5 | 3 | 2 | 0 | * |
| Colon answers recovering particles small dose group | 10 | 3 | 3 | 4 | 0 | |
| Colon answers recovering particles middle dose group | 10 | 5 | 2 | 3 | 0 | * |
| Colon answers recovering particles large dosage group | 10 | 7 | 2 | 1 | 0 | ** |
Note：* is p<0.01, * p<0.05
-：Cell tissue is complete, has no cell infiltration；+：Cell tissue is more complete, accidental cell infiltration；++：It can be seen that a small amount of
Cell infiltration；+++：The a large amount of cell infiltrations of cell, a small amount of proliferation of fibrous tissue；
It is obtained through ridit inspection, compared to the blank group, significant pathological change occurs in model group colonic tissue（p<0.01）, mucous membrane
Necrosis, ulcer are formed, and illustrate modeling success.Compared with model group, colon answers recovering particles large dosage group mucous membrane of colon and knot of tissue
Structure is substantially complete, can significantly improve colonic ulcer（p<0.01）；Colon answers recovering particles middle dose group and pill for strengthening spleen and intestines group is accidental
Necrotic tissue, body of gland marshalling, it is seen that a large amount of goblet cells, a little lymphocytic infiltration of mucous layer, colonic tissue is obvious to be obtained
To improvement（p<0.05）；Colon answers recovering particles small dose group and only has the trend for improving colon pathological change（p>0.05）.
4. conclusion
Colon answers that recovering particles are big, middle dose group can significantly improve diarrhea.Colon answers that recovering particles are big, middle dose group can be significantly reduced
The content of EGF in rat model colonic tissue, colon, which answers recovering particles large dosage group, can be significantly reduced rat model colonic tissue
The content of middle MDA, colon answer the content that recovering particles middle dose group can be substantially reduced MDA in rat model colonic tissue.Colon
Multiple recovering particles large dosage group can significant elevation model rat blood serum SOD activity, significant decrease rat model Serum TNF-α, IL-6
Content；Colon answer recovering particles middle dose group and pill for strengthening spleen and intestines group can significant elevation model rat blood serum SOD activity, significantly reduce
Rat model blood serum IL-6 content is substantially reduced rat model Serum TNF-α content.
Colon, which answers recovering particles large dosage group, can be such that rat model index and spleen index significantly reduces.Large dosage of colon answers recovering particles group
Rats Spleen Splenic structure is normal, and periarterial lymphatic sheath, acini lienalis and marginal zone is distributed in white pulp around central artery；Leaching
Bar sheath and acini lienalis are mainly made of lymphocyte, and marginal zone is mainly made of macrophage and lymphocyte；Red pulp mainly by
Splenic cords and splenic sinusoid composition, are made of lymphocyte, thick liquid cell, macrophage, Dendritic Cells and red blood cell, have no that pathology changes
Become.Middle dosage colon answers that recovering particles group Rats Spleen structure is normal, and periarterial lymph is distributed in white pulp around central artery
Sheath, acini lienalis and marginal zone；Lymph sheath and acini lienalis are mainly made of sparse lymphocyte, and marginal zone is mainly by macrophage
It is constituted with lymphocyte；Red pulp is mainly made of splenic cords and splenic sinusoid, thin by lymphocyte, thick liquid cell, macrophage, dendron shape
Born of the same parents and red blood cell are constituted, and quantity is substantially close with blank group, have no obvious pathological change.Low dose of colon answers recovering particles group rat
See that white pulp acini lienalis quantity increased significantly under spleen mirror, volume increases, average diameter 380um, lymphocyte dense arrangement；Red pulp
Splenic cords and splenic sinusoid lymphocyte increase with macrophage, and macrophage proliferation is obvious, and each high power field is about 5, big portion
It is divided into multicore, may is some cases spleen extravasated blood caused by immune response.Colon, which answers recovering particles large dosage group, significantly to be changed
Kind Ulcerative Colitis Model spleen tissue form；Colon, which answers recovering particles middle dose group, can obviously improve Ulcerative Colitis Model
The tissue morphology of spleen.
Large dosage of colon answers recovering particles group Colonic Mucosa of The Rat and is coated simple columnar epithelium, body of gland marshalling, it is seen that big
Measure goblet cell, accidental lymph nodule under mucous membrane, mucous layer mild inflammatory cellular infiltration.Middle dosage colon answers recovering particles group rat
Ulcer is formed, and mucous membrane lacks such as, it is seen that necrotic tissue, bleeding, inflammatory cell infiltration, granulation tissue, ulcer edge mucous epithelium increase
Life jump, considers atypical hyperplasia.Low dose of colon is answered recovering particles group rat colon ulcer and is formed, and mucous membrane lacks such as, it is seen that necrosis
Tissue, bleeding, massive inflammatory cells infiltrated, granulation tissue, ulcer edge mucous epithelium hyperplasia, and see nuclear fission, consider not allusion quotation
Type hyperplasia.Colon answers recovering particles large dosage group mucous membrane of colon and institutional framework is substantially complete, can significantly improve knot caused by modeling
Enterelcosis；Colon answers the accidental necrotic tissue of recovering particles middle dose group, body of gland marshalling, it is seen that a large amount of goblet cells, mucous layer
A little lymphocytic infiltration, colonic tissue are obviously improved.
Two, clinical test
On the basis of animal experiment ensures safety, and through clinical test, effect is very good, and related clinical trial data is as follows：
1, the standard of case is selected
Ulcerative colitis is a kind of a kind of intestines problem for being confined to colon film carrier and colon film carrier lower layer, and bloody diarrhea is most
Common early symptom.Other symptoms successively have abdominal pain, hematochezia, weight loss, tenesmus, vomiting etc..Main performance once in a while
For arthritis, iridocyclitis, hepatosis and cutaneous lesions.It is a uncommon sign that fever is then opposite, big
This disease is shown as chronic, low pernicious in most patients, in a few patients（Account for about 15%）In be in acute, the catastrophic process broken out.
These patients show as frequently hemorrhagic excrement, can up to 30 times/day and high fever, abdominal pain.
Sign is directly related with stadium and clinical manifestation, and patient often has weight loss and pale complexion, in disease activity
Colon site often has tenderness when phase abdomen examination.May have that acute abdomen sign occurs together heat and gurgling sound is reduced, in acute attack or
Fulminant type case is particularly evident.Can there are abdominal distension, fever and acute abdomen sign when toxic megacolon.Due to frequent diarrhea, crissum
Skin can have scratch, strip off.Crissum inflammation such as anal fissure or anal fistula can also occur, although the latter is more common in Crohn disease.Directly
Intestines refer to inspection sense pain.Skin, mucous membrane, tongue, the inspection of joint and eye are particularly important.
With above-mentioned symptom person, the standard of selection case can be used as.
2, diagnostic criteria
1. diarrhea, abdominal pain occurs in patient, there is bloody stool in when defecation.2. stool routine is detected as the body that finds the cause of disease.3. x-ray clysis with barium
Show that patient's intestines film carrier is in granular or nodal-like, intestines film carrier wrinkles, and wall is coarse, disorder.4. patient occur during one's sickness anaemia,
The diseases such as low albumen disease, water and electrolyte disorder, and with arthritis, canker sore etc..
3, therapeutic scheme
The daily oral colon for the treatment of group answers recovering particles, 3 times a day, 1-2 bags each, every bag of 5g, successive administration 30d.Control group is every
Day takes lavo-ofloxacin 2 times, each 0.15g, and 30d is used in conjunction in daily sulfasalazine 3 times, each 0.1g.
4, efficacy assessment standard
It cures：By treatment after, the symptoms such as diarrhea, abdominal pain completely disappear, x-ray barium meal show patient colon film carrier restore to
Normal physiological form, general reaction and parenteral reaction during one's sickness disappear.
Effectively：Into after crossing treatment, clinical manifestation, which is appointed, so to be existed, but is taken an evident turn for the better before relatively treatment, and X-ray barium meal is shown
Patient's colon film carrier form is restored substantially to normal physiological form, and the general reaction of patient and parenteral reaction are also relieved.
In vain：After treatment patients, ulcerative colitis is not clearly better, what partial symptoms even occurred deteriorating
Situation.
5, statistical procedures
Through being treated to the patients of ulcerative colitis made a definite diagnosis, wherein male patient 24,62 years old highest age, minimum year
Age 33 years old, average age 46 years old；Female patient 20,63 years old highest age, minimum age 33 years old, average age 47 years old.By this
44 patients are randomly divided into two groups, wherein 22 patients of control group；Treatment group 22.Two groups in age, gender, the course of disease and disease
Severity of feelings etc. without significant difference, is comparable.
After two groups receive 30d treatment, the state of an illness is improved, wherein treatment group 24, and 11 healings, 12 are effectively, and 1
In vain, efficient is 95.8%；Control group 20,8 healings, 8 effectively, and 4 invalid, and effective percentage is 80%.
6, conclusion
Experiment shows that instant component compatibility is scientific and reasonable, abundant raw material, and preparation easy to produce is at low cost, convenient to take, effect
It is good.Chinese yam, Poria cocos replenish qi to invigorate the spleen excreting dampness as monarch in side, and semen coicis invigorating spleen to remove dampness and energy clearing away heat and eliminating pus close and fry Semen Lablab Album principal drug assistance
With strengthening the spleen and replenishing qi, and can antidiarrheal.Coloured malt reinforcing spleen to promote digestion, and dispersing stagnated hepatoqi, stir-baked FRUCTUS CRATAEGI food digesting stomach fortifying, scattered stasis；Purslane,
Honeysuckle is clearing heat and detoxicating, and it is altogether ministerial drug that scattered blood, which disappears carbuncle,.Assistant is relieved pain with Radix Paeoniae Alba nourishing blood and liver, dried orange peel regulating qi-flowing for strengthening spleen stomach function regulating, and dark plum is puckery
Intestines promote the production of body fluid, rhizoma zingiberis, cortex cinnamomi can warming spleen and stomach for dispelling cold analgesic, and can anti-cold medicine object hinder stomach hurt in.Radix glycyrrhizae preparata invigorating spleen reconciles all
Medicine.Take a broad view of full side, bowl spares gas, excreting dampness is turbid, and promoting the circulation of qi is stagnant, clear stagnant heat, makes the strong fortune of temper, damp and hot, ecchymosis so evil that go, then all diseases from
It removes.And the present invention finds no toxic side effect and adverse reaction in experiment, shows drug safety, and curative effect is reliable and stable,
Curative effect is up to 95% or more, is the innovation treated on ulcerative colitis drug, there is significant economic and social benefit.
Claims (4)
1. a kind of Chinese medicinal granule for treating ulcerative colitis, which is characterized in that by poidometer：10-14 grams of stir-baked RHIZOMA DIOSCOREAE, coix lacryma-jobi
10-14 grams of benevolence, 5-7 grams of coloured malt, 5-7 grams of stir-baked FRUCTUS CRATAEGI, 7-11 grams of purslane, 5-7 grams of Radix Paeoniae Alba, fries Semen Lablab Album at 10-14 grams of Poria cocos
7-11 grams, 5-7 grams of dark plum, 5-7 grams of rhizoma zingiberis, 5-7 grams of radix glycyrrhizae preparata, 7-11 grams of dried orange peel, 7-11 grams of honeysuckle and cortex cinnamomi 4-6 restrain
At, wherein the Chinese medicine that stir-baked RHIZOMA DIOSCOREAE, coloured malt, stir-baked FRUCTUS CRATAEGI, stir-fry Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into 80 meshes is thin
Powder, residual drug decocting are extracted twice, and for the first time plus the water of 8 times of residual drug weight, immersion 30 minutes are boiled by fire, and are turned small
Fire decocts 30 minutes, and filtering obtains first time decocting liquid, the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turn small fire
It decocts 30 minutes, filtering obtains second of decocting liquid, merges decocting liquid twice, spray drying is mixed with traditional Chinese medicine fine powder, is made
Medicine particle.
2. the Chinese medicinal granule for the treatment of ulcerative colitis according to claim 1, which is characterized in that by poidometer：It fries
12 grams of Chinese yam, 12 grams of Poria cocos, 6 grams of coloured malt, 6 grams of stir-baked FRUCTUS CRATAEGI, 9 grams of purslane, 6 grams of Radix Paeoniae Alba, fries Semen Lablab Album 9 at 12 grams of semen coicis
Gram, 6 grams of dark plum, 6 grams of rhizoma zingiberis, 6 grams of radix glycyrrhizae preparata, 9 grams of dried orange peel, 9 grams of honeysuckle and cortex cinnamomi 5 restrain at, wherein by stir-baked RHIZOMA DIOSCOREAE, fry
Malt, stir-baked FRUCTUS CRATAEGI fry the traditional Chinese medicine fine powder that Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into 80 meshes, and residual drug decocting is extracted
Twice, add the water of 8 times of residual drug weight for the first time, impregnate 30 minutes, be boiled by fire, turn small fire and decoct 30 minutes, filtering obtains
First time decocting liquid, the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turn small fire and decoct 30 minutes, and filtering obtains the
Secondary decocting liquid, merges decocting liquid twice, and spray drying mixes with traditional Chinese medicine fine powder, Chinese medicinal granule is made.
3. the Chinese medicinal granule for the treatment of ulcerative colitis according to claim 1, which is characterized in that by poidometer：It fries
11 grams of Chinese yam, 13 grams of semen coicis, 11 grams of Poria cocos, 6.5 grams of coloured malt, 5.5 grams of stir-baked FRUCTUS CRATAEGI, 8 grams of purslane, 6.5 grams of Radix Paeoniae Alba, stir-fry are white
8 grams of hyacinth bean, 6.5 grams of dark plum, 5.5 grams of rhizoma zingiberis, 6.5 grams of radix glycyrrhizae preparata, 8 grams of dried orange peel, 10 grams of honeysuckle and cortex cinnamomi 4.5 restrain at,
In, stir-baked RHIZOMA DIOSCOREAE, coloured malt, stir-baked FRUCTUS CRATAEGI, stir-fry Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into the traditional Chinese medicine fine powder of 80 meshes, remained
Remaining drug decocting is extracted twice, and for the first time plus the water of 8 times of residual drug weight, immersion 30 minutes are boiled by fire, and turns small fire decoction
30 minutes, filtering obtained first time decocting liquid, and the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turns small fire and decocts 30
Minute, filtering obtains second of decocting liquid, merges decocting liquid twice, and spray drying mixes with traditional Chinese medicine fine powder, Chinese medicinal granule is made.
4. the Chinese medicinal granule for the treatment of ulcerative colitis according to claim 1, which is characterized in that by poidometer：It fries
13 grams of Chinese yam, 13 grams of Poria cocos, 5.5 grams of coloured malt, 6.5 grams of stir-baked FRUCTUS CRATAEGI, 10 grams of purslane, 5.5 grams of Radix Paeoniae Alba, is fried 11 grams of semen coicis
10 grams of Semen Lablab Album, 5.5 grams of dark plum, 6.5 grams of rhizoma zingiberis, 5.5 grams of radix glycyrrhizae preparata, 10 grams of dried orange peel, 8 grams of honeysuckle and cortex cinnamomi 5.5 restrain at,
Wherein, stir-baked RHIZOMA DIOSCOREAE, coloured malt, stir-baked FRUCTUS CRATAEGI, stir-fry Semen Lablab Album, rhizoma zingiberis, dried orange peel, cortex cinnamomi were ground into the traditional Chinese medicine fine powder of 80 meshes,
Residual drug decocting is extracted twice, and for the first time plus the water of 8 times of residual drug weight, immersion 30 minutes are boiled by fire, and is turned small fire and is decocted
It boils 30 minutes, filters, obtain first time decocting liquid, the dregs of a decoction add the water of 6 times of weight of residual drug again, are boiled by fire, and turn small fire decoction
30 minutes, filtering obtained second of decocting liquid, merged decocting liquid twice, and spray drying mixes with traditional Chinese medicine fine powder, Chinese medicine is made
Grain.
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