CN108815435A - A kind of preparation method of the Chinese medicine composition for treating pruritus dermatopathy and its preparation - Google Patents
A kind of preparation method of the Chinese medicine composition for treating pruritus dermatopathy and its preparation Download PDFInfo
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Abstract
The present invention provides the preparation methods of a kind of Chinese medicine composition for treating pruritus dermatopathy and its preparation, are made of the bulk pharmaceutical chemicals of following parts by weight：40-160 parts of kuh-seng, 30-150 parts of dandelion, 30-150 parts of uncaria, 30-130 parts of the achene of Siberian cocklebur, 40-120 parts of cortex dictamni, 30-100 parts of the fruit of summer cypress, 20-100 parts of garden burnet, 30-120 parts of Cortex Phellodendri, 30-100 parts of frutus cnidii, 20-90 parts of the tuber of stemona, 20-80 parts of Golden Larch Bark, 1-10 parts of borneol, 1-10 parts of menthol.The Chinese materia medica preparation has securely and reliably, and raw material are easily purchased, moderate, is readily produced, the dermopathic special efficacy for the treatment of with wide spectrum.
Description
Technical field
The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of Chinese medicine composition for treating pruritus dermatopathy and its system
The preparation method of agent.
Background technique
Skin disease be a kind of common disease, frequently-occurring disease, it is susceptible catch an illness, each kind of groups of men and women, old and young, spring, summer, autumn and winter in each season
Will morbidity, the dermopathic cause of disease be it is various, the pain of clinical manifestation and patient be also it is diversified, seriously endanger
The health of the mankind.Currently, smear certain ointment or liquid medicine to general skin disease, simultaneous to take certain medicines for oral administration be most commonly
Way, but dermopathic ointment or liquid medicine are treated mainly based on chemical medicinal ingredient and the effect for the treatment of is relatively simple, it is long
Phase is also gradually embodied using rear dermopathic drug resistance, and particularly with treatment psoriasis, this kind of skin disease such as psoriasis cannot
Treatment is basic, and drug effect is often unobvious.
Pruritus dermatopathy refers to one group of skin disease using pruitus as main feature, including pruitus and original
Hair property skin rash simultaneously and the pruritus dermatopathy deposited, such as eczema, psoriasis, neurodermatitis, papular urticaria, insect bite
Inflammation, pityriasis rubra etc. also include the cutaneous pruritus for only having pruitus and lacking primary cutaneous fash.
The external drug for the treatment of pruritus dermatopathy is mainly glucocorticosteroid and some Chinese patent medicine preparations at present.According to
Finding shows that the Chinese medicine compound prescription external preparation type currently used for treating pruritus dermatopathy is limited and curative effect is not good enough, and
For glucocorticosteroid because having the function of anti-inflammatory and anti-proliferate, treatment may obtain better effects in the recent period, but cause therewith
Glucocorticosteroid relies on and withdrawal recurrence, affects therapeutic effect, and long-time service is also possible to will appear such as thinning of skin, hair follicle
The side effects such as atrophy, acne even steroid dependent dermatitis.In addition, medical personnel is in clinical position, it was also found that just with sugar
Corticosteroid formulations generally show preferable therapeutic effect, are further continued for being decreased obviously using its curative effect after a few days, that is, occur
The tachysnthsis and tolerance phenomenon of external application hormone, and then the difficulty for the treatment of is increased, it is almost helpless to intractable case.This
Outside, external application immunosuppressor is gradually applied to clinic, although its is significant in efficacy, also without the side effect of Glucocorticoid,
But because it is expensive, it is heavier that patient economy burden is used for a long time.Traditional Chinese medicine exists a lot in terms for the treatment of pruritus dermatopathy
The utilization of advantage, especially Chinese medicine compound prescription, it is anti-that clinical and experiment proves that traditional Chinese medicine has in terms for the treatment of pruritus dermatopathy
Antibacterial, anti-inflammatory, antipruritic, clearing heat and detoxicating and immunoregulation effect, and it is cheap, this makes us seek to treat pruritic skin
By huge inspiration in terms of the Chinese medicine of disease.Meanwhile allow at present many dermatologists work be difficult to the reason of carrying out first is that very
Difficulty finds a kind of high-efficiency low-toxicity, the drug of reasonable price meets the needs of conditions of patients and economic capability, thus actively find and
Develop it is a kind of treat pruritus dermatopathy good effect, Small side effects and the suitable pure Chinese medicine compound external-use preparation of price have it is very big
Clinical value and potential of demand, have realistic meaning too impatient to wait.
Summary of the invention
To solve the above problems, the present invention provides the system of a kind of Chinese medicine composition for treating pruritus dermatopathy and its preparation
Preparation Method, the Chinese materia medica preparation have securely and reliably, and raw material are easily purchased, moderate, are readily produced, the treatment skin with wide spectrum
The special efficacy of disease.
The object of the present invention is achieved in the following manner：
A kind of Chinese medicine composition for treating pruritus dermatopathy, is made of the component of following parts by weight：40-160 parts of kuh-seng, Pu
Public English 30-150 parts, 30-150 parts of uncaria, 30-130 parts of the achene of Siberian cocklebur, 40-120 parts of cortex dictamni, 30-100 parts of the fruit of summer cypress, garden burnet
20-100 parts, it is 30-120 parts of Cortex Phellodendri, 30-100 parts of frutus cnidii, 20-90 parts of the tuber of stemona, 20-80 parts of Golden Larch Bark, 1-10 parts of borneol, thin
1-10 parts of lotus brain.
A kind of Chinese medicine composition for treating pruritus dermatopathy, is made of the component of following parts by weight：Kuh-seng 80-140
Part, 70-120 parts of dandelion, 70-120 parts of uncaria, 50-100 parts of the achene of Siberian cocklebur, 60-100 parts of cortex dictamni, 50-90 parts of the fruit of summer cypress,
50-90 parts of elm, 50-100 parts of Cortex Phellodendri, 40-80 parts of frutus cnidii, 40-80 parts of the tuber of stemona, 30-70 parts of Golden Larch Bark, 2-6 parts of borneol, peppermint
2-6 parts of brain.
A kind of Chinese medicine composition for treating pruritus dermatopathy, is made of the component of following parts by weight：120 parts of kuh-seng,
100 parts of dandelion, 100 parts of uncaria, 80 parts of the achene of Siberian cocklebur, 80 parts of cortex dictamni, 70 parts of the fruit of summer cypress, 70 parts of garden burnet, 65 parts of Cortex Phellodendri, cnidium monnieri
Sub 60 parts, 60 parts of the tuber of stemona, 50 parts of Golden Larch Bark, 2 parts of borneol, 3 parts of menthol.
A kind of preparation method of Chinese materia medica preparation that treating pruritus dermatopathy, includes the following steps：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 4-12 times of weight solvent soaking 0-24 hours, are extracted 2 times, for the first time
Be heated to reflux 2-4 hours, collect an extracting solution, then plus 4-12 times of weight solvent be heated to reflux 1-3 hours, collect two
Secondary extracting solution merges secondary raffinate, and filtering, it is 1.10~1.30 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, temperature
It is spare for 50-60 DEG C of paste；
（3）By above-mentioned paste, borneol, menthol according to common process, customary adjuvant is added, paste, spray or gel is made
Equal external preparations.
Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is（0.05-4）：1.
A kind of preparation method of Chinese materia medica preparation that treating pruritus dermatopathy, includes the following steps：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）It pulverizes and sieves：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are ground into coarse powder, cross 40-80 mesh；
（3）Borneol, menthol is added in above-mentioned herb powder, according to liquid extract and extract conventional fabrication process be made paste,
The external preparations such as spray or gel.
Chinese medicine preparation is based on clearing heat and detoxicating, dispelling wind and eliminating dampness, by resisting antibacterial, desinsection, improves skin itching symptom,
Reach antipruritic, treats the dermopathic purpose of tinea class.
Outside the characteristics of Chinese materia medica preparation of the invention has securely and reliably, and raw material are easily purchased, moderate, is readily produced, most
Important is the dermopathic special efficacys for the treatment of that Chinese materia medica preparation of the invention has wide spectrum.
The influence factor of pruitus includes：
1, fungi or bacterium infection：This be pruitus at most, most direct occurrence cause.
2, bite by mosquitos：Bite by mosquitos can lead to insect bite dermatitis, generate the symptom of itch.
3, climate change：Outside removing humidity weather, winter climate cold is dry, and human skin also becomes dry and astringent coarse, even
Excoriation is also easy to keep intradermal nerve endings stimulated and itch.
4, allergic reaction：It is multiple if pollen hypersensitivity or contact allergy are former because of food, drug, worm poison or other allergies
In allergic constitution person.
Chinese medicine thinks, be pruitus the main reason for such as ailment said due to cold or exposure, damp evil, heat evil, the deficiency of blood, worm are excessive, and treatment should be with dispelling wind
Clearing damp, clearing heat and detoxicating, enriching the blood to restore normal menstruation are principle, to reach the effect of righting of getting rid of evils is antipruritic.
Tinea class skin disease is mainly due to inernal injuries caused by seven emotions, ailment said due to cold or exposure are invaded and harassed, so that battalion defends and becomes estranged, passages through which vital energy circulates, which loses, to be dredged and cause.
The resistance of wind-heat heresy：Body surface is attacked outside ailment said due to cold or exposure, it is strongly fragrant to change heat in the flesh natural fibre line of meat, ying blood excess heat is caused, passages through which vital energy circulates is full of, body macular eruption rash.If
Ailment said due to cold or exposure is controlled long, is lied prostrate in skin space between skin and muscles, and passages through which vital energy circulates is become estranged, and leads to wound battalion hematozemia, then obstinate disease.
Blood-head wind is contained：Ailment said due to cold or exposureization heat or inernal injuries caused by seven emotions, it is edgy, change heat fostering fire, burning hot volt in ying blood, become estranged by ying blood,
Passages through which vital energy circulates be full of, then dermexanthesis spot and color is red.Blood hot air wind producing, wind Sheng is then dry, and sees itching, takes off dry scurf.
Blood-deficiency and wind-dry：Feelings will is strongly fragrant without reaching, and changes heat fostering fire, with the passing of time then consumes impairment of yin blood.Nutrient QI and blood being insufficient, the raw wind of dryness-transformation, skin
Dystrophy, passages through which vital energy circulates, which loses, to be dredged, therefore macular eruption rash dermatitis, surprise are itched unbearably.
In short, feelings will internal injury, ailment said due to cold or exposure invasion is the risk factor of this disease；It is disharmony between ying and wei, passages through which vital energy circulates lose dredge be this disease the interpretation of the cause, onset and process of an illness
Feature.Clothing friction, is scratched repeatedly, is unfavorable for ying blood and adjusting and is dredged with passages through which vital energy circulates sharp, then can aggravate that disease damage is coarse to be thickened.
This disease is damaged by excess of seven emotions, and mostly because raw in internal heat, the spleen channel is damp and hot, and lung channel wind toxin visitor is between skin space between skin and muscles, exogenous disease wind
Damp and hot heresy, so that retardance skin, deficiency of blood life is dry, and skin loses caused by honor.
Chinese medicine preparation is based on clearing heat and detoxicating, dispelling wind and eliminating dampness, by resisting antibacterial, desinsection, improves skin itching symptom,
Reach antipruritic, treats the dermopathic purpose of tinea class.
Each ingredient effect of the present invention is as follows：
Kuh-seng has heat-clearing and damp-drying drug, desinsection, the effect of diuresis；For hot dysentery, hematochezia, jaundice urodialysis, leukorrhea with reddish discharge, swelling of vulva yin
Itch, eczema, wet sore, pruitus, castor etc..
Dandelion has clearing heat and detoxicating, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating strangurtia；For furuncle swelling toxin, acute mastitis, scrofula, mesh
It is red, pharyngalgia, pulmonary abscess, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Uncaria has The flat liver of heat-clearing, the effect of relieving convulsion and spasm；Excess heat moves wind frightened epilepsy, child convulsion, the morbid night crying of babies, eclampsia, apoplexy
Paralysis, podomere contraction are anxious.
The achene of Siberian cocklebur has dispersing wind and cold, clearing the nasal passage, wind-damp dispelling, antipruritic effect.For nasosinusitis, anemofrigid headache, rheumatism, numbness
Bitterly, rubeola, eczema, scabies.
Cortex dictamni has wind-dispelling, eliminating dampness, heat-clearing, the effect of removing toxic substances.Control wind-heat sore, scabies, itchy skin eruption, rheumatism numbness
Bitterly, jaundice.
The fruit of summer cypress has diuresis, the effect of clearing away damp-heat.Control difficult urination, stranguria syndrome, leukorrhagia, hernia, rubeola, sore, scabies
Tinea, private parts is wet to itch.
Garden burnet has the function of blood-stanching and blood-cooling, clearing heat and detoxicating, astringing to arrest diarrhea and a variety of pathogenic microorganisms of inhibition and tumour,
Can treat haematemesis, bloody flux, burn the big bleeding of wound, eczema, upper gastrointestinal bleeding, canker, hematochezia, metrorrhagia and metrostaxis, Tuberculous purulence ulcer and
The diseases such as chronic osteomyelitis.
Cortex Phellodendri has the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice and reddish urine, leukorrhagia
Pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is preesed, hectic fever due to yin labor heat, night sweat, spermatorrhea, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire.With
In fire excess from yin deficiency, night sweat hectic fever due to yin.
Frutus cnidii has eliminating dampness wind-dispelling, and desinsection is antipruritic, the effect of warming kidney and enhancing body.For pruritus vulvae leukorrhagia, eczema itch are wet
Numbness pain in the loins, impotence due to deficiency of the kidney, uterus cold infertile.
The tuber of stemona has gentle lung qi, cough-relieving, the effect of desinsection.For cough due to wind-cold evil, pertussis, pulmonary tuberculosis, old cough
Asthma, roundworm, enterobiasis, skin scabies, eczema.
Golden Larch Bark has the function of Anti-Puritic and insecticidal.For trick tinea, neurodermatitis, eczema, leprosy dysentery head.
It is above to prove that the present invention be widely used in treatment all kinds of itch of skin, stubborn dermatitis, ringworm of the body, jock itch, favus of the scalp, the tinea manuum,
Dermatitis, eczema, epifolliculitis, nettle rash, solar dermatitis etc..
Specific embodiment
Embodiment 1：
A kind of Chinese medicine composition for treating pruritus dermatopathy, is made of the bulk pharmaceutical chemicals of following parts by weight：40-160 parts of kuh-seng,
30-150 parts of dandelion, 30-150 parts of uncaria, 30-130 parts of the achene of Siberian cocklebur, 40-120 parts of cortex dictamni, 30-100 parts of the fruit of summer cypress, garden burnet
20-100 parts, it is 30-120 parts of Cortex Phellodendri, 30-100 parts of frutus cnidii, 20-90 parts of the tuber of stemona, 20-80 parts of Golden Larch Bark, 1-10 parts of borneol, thin
1-10 parts of lotus brain.
The preparation method of Chinese materia medica preparation is made using the Chinese medicine composition of above-mentioned treatment pruritus dermatopathy, feature exists
In：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 4-12 times of weight solvent soaking 0-24 hours, extract 2 times, and first
It is secondary to be heated to reflux 2-4 hours, collect an extracting solution, then plus 4-12 times of weight solvent be heated to reflux 1-3 hours, collect
Secondary raffinate merges secondary raffinate, and filtering, it is 1.10~1.30 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, temperature
The paste that degree is 50-60 DEG C, it is spare；
（3）By above-mentioned paste, borneol, menthol according to common process, customary adjuvant is added, paste, spray or gel is made
Equal external preparations.
Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is 0.05：1.
Conventional paste preparation process, includes the following steps：
1, by step（2）In paste dissolved by heating with purified water, it is spare；
2, suitable vaseline, glycerin monostearate, stearic acid, glycerol heating are taken, stirring makes after dissolving fully, spare；
3, spare after dissolving borneol, menthol with ethyl alcohol；
4, the mixture in step 3 is added in step 2 in mixture, is stirred evenly, it is spare；
5, the mixture in step 1 is slowly added into the mixture of step 4, it is stirring while adding, make after being sufficiently mixed uniformly,
It is spare；
6, uniformly mixed ointment is filling, packaging.
Conventional spray preparation process：
1, by step（2）In paste purified water and alcohol mixture（3:1）After dissolution, stand for 24 hours, it is spare；
2, spare after dissolving borneol, menthol with ethyl alcohol；
3, the mixture in step 2 is added in the mixture in step 1, is uniformly mixed, it is spare；
4, uniformly mixed spray is filling, packaging.
Conventional GPC preparation process：
1, by step（2）In paste dissolved with 2000 parts of purified waters after, take 20 parts of carbomers to be added in aqueous solutions, be swollen 6-
8h after making complete swelling, is stirred evenly, spare；
2, spare after dissolving borneol, menthol with ethyl alcohol；
3, mixture in step 2 is added in the mixture in step 1, stirring makes to be uniformly mixed, spare；
4, triethanolamine is added, it is stirring while adding, pH value is adjusted to 5-7, and standing is for 24 hours, spare；
5, uniformly mixed gel is filling, packaging.
Embodiment 2
A kind of Chinese medicine composition for treating pruritus dermatopathy, is made of the component of following parts by weight：80-140 parts of kuh-seng, Pu
Public English 70-120 parts, 70-120 parts of uncaria, 50-100 parts of the achene of Siberian cocklebur, 60-100 parts of cortex dictamni, 50-90 parts of the fruit of summer cypress, garden burnet 50-
90 parts, 50-100 parts of Cortex Phellodendri, 40-80 parts of frutus cnidii, 40-80 parts of the tuber of stemona, 30-70 parts of Golden Larch Bark, 2-6 parts of borneol, menthol 2-6
Part.
The preparation method of Chinese materia medica preparation is made using the Chinese medicine composition of above-mentioned treatment pruritus dermatopathy, feature exists
In：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 4-12 times of weight solvent soaking 0-24 hours, are extracted 2 times, for the first time
Be heated to reflux 2-4 hours, collect an extracting solution, then plus 4-12 times of weight solvent be heated to reflux 1-3 hours, collect two
Secondary extracting solution merges secondary raffinate, and filtering, it is 1.10~1.30 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, temperature
It is spare for 50-60 DEG C of paste；
（3）By above-mentioned paste, borneol, menthol according to common process, customary adjuvant is added, paste, spray or gel is made
Equal external preparations.
Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is 1：1.
Embodiment 3
A kind of Chinese medicine composition for treating pruritus dermatopathy, it is characterised in that：It is made of the component of following weight fraction：Kuh-seng
120 parts, 100 parts of dandelion, 100 parts of uncaria, 80 parts of the achene of Siberian cocklebur, 80 parts of cortex dictamni, 70 parts of the fruit of summer cypress, 70 parts of garden burnet, Cortex Phellodendri 65
Part, 60 parts of frutus cnidii, 60 parts of the tuber of stemona, 50 parts of Golden Larch Bark, 2 parts of borneol, 3 parts of menthol.
The preparation method of Chinese materia medica preparation is made using the Chinese medicine composition of above-mentioned treatment pruritus dermatopathy, feature exists
In：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 4 times of weight solvent soaking 15 hours, are extracted 2 times, are heated for the first time
Reflux 4 hours, collects an extracting solution, then plus 12 times of weight solvents be heated to reflux 3 hours, collect secondary raffinate, close
And secondary raffinate, filtering, it is 1.10~1.30 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, the paste that temperature is 50 DEG C
Object, it is spare；
（3）By above-mentioned paste, borneol, menthol according to common process, customary adjuvant is added, paste, spray or gel is made
Equal external preparations.
Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is 4：1.
Embodiment 4
A kind of Chinese medicine composition for treating pruritus dermatopathy, is made of the bulk pharmaceutical chemicals of following parts by weight：40 parts of kuh-seng, Pu Gong
150 parts of English, 30 parts of uncaria, 130 parts of the achene of Siberian cocklebur, 40 parts of cortex dictamni, 100 parts of the fruit of summer cypress, 20 parts of garden burnet, 120 parts of Cortex Phellodendri, frutus cnidii
30 parts, 90 parts of the tuber of stemona, 20 parts of Golden Larch Bark, 10 parts of borneol, 1 part of menthol.
The preparation method of Chinese materia medica preparation is made using the Chinese medicine composition of above-mentioned treatment pruritus dermatopathy, feature exists
In：Include the following steps：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）It pulverizes and sieves：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are ground into coarse powder, cross 40-80 mesh；
（3）By above-mentioned herb powder, it is added according to external preparations such as paste, spray or gels under liquid extract and extract item
Borneol, menthol preparation.
Conventional paste preparation process, includes the following steps：
1, by step（2）In herb powder dissolved by heating with purified water, it is spare；
2, suitable vaseline, glycerin monostearate, stearic acid, glycerol heating are taken, stirring makes after dissolving fully, spare；
3, spare after dissolving borneol, menthol with ethyl alcohol；
4, the mixture in step 3 is added in step 2 in mixture, is stirred evenly, it is spare；
5, the mixture in step 1 is slowly added into the mixture of step 4, it is stirring while adding, make after being sufficiently mixed uniformly,
It is spare；
6, uniformly mixed ointment is filling, packaging.
Conventional spray preparation process：
1, by step（2）In herb powder purified water and alcohol mixture（3:1）After dissolution, stand for 24 hours, it is spare；
2, spare after dissolving borneol, menthol with ethyl alcohol；
3, the mixture in step 2 is added in the mixture in step 1, is uniformly mixed, it is spare；
4, uniformly mixed spray is filling, packaging.
Conventional GPC preparation process：
1, by step（2）In herb powder dissolved with 2000 parts of purified waters after, take 20 parts of carbomers to be added in aqueous solutions, swelling
6-8h after making complete swelling, is stirred evenly, spare；
2, spare after dissolving borneol, menthol with ethyl alcohol；
3, mixture in step 2 is added in the mixture in step 1, stirring makes to be uniformly mixed, spare；
4, triethanolamine is added, it is stirring while adding, pH value is adjusted to 5-7, and standing is for 24 hours, spare；
5, uniformly mixed gel is filling, packaging.
Embodiment 5
A kind of Chinese medicine composition for treating pruritus dermatopathy, it is characterised in that：It is made of the bulk pharmaceutical chemicals of following parts by weight：It is bitter
Join 160 parts, 30 parts of dandelion, 150 parts of uncaria, 30 parts of the achene of Siberian cocklebur, 120 parts of cortex dictamni, 30 parts of the fruit of summer cypress, 100 parts of garden burnet, Cortex Phellodendri
30 parts, 100 parts of frutus cnidii, 20 parts of the tuber of stemona, 80 parts of Golden Larch Bark, 1 part of borneol, 10 parts of menthol.
The preparation method of Chinese materia medica preparation is made using the Chinese medicine composition of above-mentioned treatment pruritus dermatopathy, feature exists
In：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 8 times of weight solvent soaking 12 hours, are extracted 2 times, are heated back for the first time
Stream 2 hours, collects an extracting solution, then plus 7 times of weight solvents be heated to reflux 2 hours, collect secondary raffinate, merge secondary mentions
Liquid is taken, is filtered, it is 1.15~1.20 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, and the paste that temperature is 60 DEG C is spare；
（3）By above-mentioned paste, borneol, menthol according to common process, customary adjuvant is added, paste, spray or gel is made
Equal external preparations.
Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is 3：1.
Embodiment 6
A kind of Chinese medicine composition for treating pruritus dermatopathy, it is characterised in that：It is made of the bulk pharmaceutical chemicals of following parts by weight：It is bitter
Join 100 parts, 100 parts of dandelion, 100 parts of uncaria, 80 parts of the achene of Siberian cocklebur, 80 parts of cortex dictamni, 80 parts of the fruit of summer cypress, 70 parts of garden burnet, Cortex Phellodendri
100 parts, 75 parts of frutus cnidii, 50 parts of the tuber of stemona, 55 parts of Golden Larch Bark, 5 parts of borneol, 5 parts of menthol.
The preparation method of Chinese materia medica preparation is made using the Chinese medicine composition of above-mentioned treatment pruritus dermatopathy, feature exists
In：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 10 times of weight solvent soaking 5 hours, are extracted 2 times, are heated back for the first time
Stream 3 hours, collects an extracting solution, then plus 8 times of weight solvents be heated to reflux 2 hours, collect secondary raffinate, merge secondary mentions
Liquid is taken, is filtered, it is 1.10~1.20 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, and the paste that temperature is 60 DEG C is spare；
（3）By above-mentioned paste, borneol, menthol according to common process, customary adjuvant is added, paste, spray or gel is made
Equal external preparations.
Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is 4：1.
Compared with the existing technology, the present invention is curative for effect in terms for the treatment of pruitus, phase in terms of cure rate and obvious effective rate
It is significantly improved for other products, and side effect very little.The following are clinical data of the present invention statistics：
Selection makes a definite diagnosis pruitus patient 200, the age 8-70 years old, is randomly divided into 4 groups, treats 1 group（Paste group of the present invention）52
Example, male 22, treat 2 groups by female 30（Spray group of the present invention）56, male 23, treats 3 groups by female 33（Inventive gel
Group）47, male 18, female 29, control group（Reference agent group）45, male 16, female 29, the course of disease 5 months ~ 15 years, four
There was no significant difference in terms of sex, age, course of disease, etc. before group case treatment, is comparable.
Diagnostic criteria：Meet《Clinic skin disease blood》The diagnostic criteria of pruritus, exclusion criteria：Diabetes, Chronic Liver
Itch caused by the viscera diseases such as disease, chronic kidney disease, renal insufficiency, internal tumor, autoimmune disease；It is taken in 1 week
Cross glucocorticoid；There are drug or food hypersenstivity history person.
Treatment method：
Treat 1 group, treatment 2 groups, treatment 3 groups of effective ingredient contents it is identical, only dosage form is had any different.
Treat 1 group：Paste application of the present invention is given in affected part, it is 3 times a day, each primary in the morning, afternoon and evening.
Treat 2 groups：It gives spray of the present invention and is applied to affected part, it is 3 times a day, each primary in the morning, afternoon and evening.
Treat 3 groups：It gives inventive gel and is applied to affected part, it is 3 times a day, each primary in the morning, afternoon and evening.
Control group：It gives reference agent and is applied to affected part, it is 3 times a day, each primary in the morning, afternoon and evening.
During treatment, the pungent stimulation food such as four groups of equal fasting wine, seafood.
Criterion of therapeutical effect：
Recovery from illness：Skin itching symptom all disappears；
It is effective：The degree improvement 70%-90% of pruitus；
Effectively：The degree improvement 30%-70% of pruitus；
In vain：The degree of pruitus is not improved.
Treatment results：Specifically it is shown in Table 1
1 four groups of Clinical efficacy comparisons of table
| Group | Number of cases | Recovery from illness | It is effective | Effectively | In vain | Total effective rate（%） |
| Treat 1 group | 52 | 27 | 14 | 7 | 4 | 92.3 |
| Treat 2 groups | 56 | 31 | 15 | 7 | 3 | 94.6 |
| Treat 3 groups | 47 | 24 | 11 | 9 | 3 | 93.6 |
| Control group | 45 | 6 | 11 | 16 | 12 | 73.3 |
Note：Each treatment group is compared with the control group（P < 0.01）.
As seen from the above table：Each treatment group（Treat 1 group（Paste group of the present invention）, treatment 2 groups（Spray group of the present invention）, treatment 3
Group（Inventive gel group））The total effective rate for treating pruitus is substantially better than control group, there is significant difference.（P < 0.01）
Total effective rate no significant difference between each treatment group.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those skilled in the art,
Without depart from that overall concept of the invention, several changes and improvements can also be made, these also should be considered as of the invention
Protection scope.
Claims (6)
1. a kind of Chinese medicine composition for treating pruritus dermatopathy, it is characterised in that：It is made of the component of following parts by weight：It is bitter
Join 40-160 parts, 30-150 parts of dandelion, 30-150 parts of uncaria, 30-130 parts of the achene of Siberian cocklebur, 40-120 parts of cortex dictamni, the fruit of summer cypress
30-100 parts, 20-100 parts of garden burnet, 30-120 parts of Cortex Phellodendri, 30-100 parts of frutus cnidii, 20-90 parts of the tuber of stemona, 20-80 parts of Golden Larch Bark,
1-10 parts of borneol, 1-10 parts of menthol.
2. the Chinese medicine composition for the treatment of pruritus dermatopathy according to claim 1, it is characterised in that：By following parts by weight
Several components are made：80-140 parts of kuh-seng, 70-120 parts of dandelion, 70-120 parts of uncaria, 50-100 parts of the achene of Siberian cocklebur, cortex dictamni
60-100 parts, 50-90 parts of the fruit of summer cypress, 50-90 parts of garden burnet, 50-100 parts of Cortex Phellodendri, 40-80 parts of frutus cnidii, 40-80 parts of the tuber of stemona, soil
30-70 parts of chaste tree skin, 2-6 parts of borneol, 2-6 parts of menthol.
3. the Chinese medicine composition for the treatment of pruritus dermatopathy according to claim 1, it is characterised in that：By following parts by weight
Several components are made：120 parts of kuh-seng, 100 parts of dandelion, 100 parts of uncaria, 80 parts of the achene of Siberian cocklebur, 80 parts of cortex dictamni, the fruit of summer cypress 70
Part, 70 parts of garden burnet, 65 parts of Cortex Phellodendri, 60 parts of frutus cnidii, 60 parts of the tuber of stemona, 50 parts of Golden Larch Bark, 2 parts of borneol, 3 parts of menthol.
4. the preparation method of Chinese materia medica preparation is made using the Chinese medicine composition for the treatment of pruritus dermatopathy described in claim 1,
It is characterized in that：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）Solvent extraction：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are placed in extractor, after 4-12 times of weight solvent soaking 0-24 hours, are extracted 2 times, for the first time
Be heated to reflux 2-4 hours, collect an extracting solution, then plus 4-12 times of weight solvent be heated to reflux 1-3 hours, collect two
Secondary extracting solution merges secondary raffinate, and filtering, it is 1.10~1.30 that solvent, which is recovered under reduced pressure, and is concentrated into relative density, temperature
It is spare for 50-60 DEG C of paste；
（3）By above-mentioned paste, borneol, menthol according to common process, be added customary adjuvant be made cream, ointment, bar
The external preparations such as plaster ointment, spray or gel.
5. the preparation method of Chinese materia medica preparation is made in the Chinese medicine composition for the treatment of pruritus dermatopathy as claimed in claim 4,
It is characterized in that：Step（2）In solvent be ethyl alcohol and purified water mixture, the ratio of ethyl alcohol and purified water is 1：（0.05-
4）.
6. the preparation method of Chinese materia medica preparation is made in the Chinese medicine composition for the treatment of pruritus dermatopathy as described in claim 1,
It is characterized in that：Include the following steps：
（1）Ingredient：Weigh according to parts by weight kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri,
Frutus cnidii, the tuber of stemona, Golden Larch Bark, borneol, menthol are spare；
（2）It pulverizes and sieves：By weighed kuh-seng, dandelion, uncaria, the achene of Siberian cocklebur, cortex dictamni, the fruit of summer cypress, garden burnet, Cortex Phellodendri, cnidium monnieri
Son, the tuber of stemona, Golden Larch Bark are ground into coarse powder, cross 40-80 mesh；
（3）Borneol, menthol is added in above-mentioned herb powder, according to liquid extract and extract conventional fabrication process be made paste,
The external preparations such as spray or gel.
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Application publication date: 20181116 |
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| RJ01 | Rejection of invention patent application after publication |