CN108815371A - Chinese medicine composition and preparation method thereof for treating Alzheimer disease - Google Patents

Chinese medicine composition and preparation method thereof for treating Alzheimer disease Download PDF

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Publication number
CN108815371A
CN108815371A CN201810767567.XA CN201810767567A CN108815371A CN 108815371 A CN108815371 A CN 108815371A CN 201810767567 A CN201810767567 A CN 201810767567A CN 108815371 A CN108815371 A CN 108815371A
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王以科
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Wuhu Mao Chi Biotechnology Co Ltd
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Wuhu Mao Chi Biotechnology Co Ltd
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Abstract

The invention discloses a kind of Chinese medicine composition and preparation method thereof for treating Alzheimer disease, the preparation method includes：Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, decocts for the first time respectively later and second decocts, filtered fluid M is obtained after filtering；It is ground after rheum officinale, cordyceps sinensis, Radix Polygalae, Flos Albiziae, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are mixed, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, obtains the Chinese medicine composition after mixture A is sterilized, dry；The preparation method of the Chinese medicine composition of offer is simple, raw material is easy to get, while therapeutic effect is good, without side-effects.

Description

Chinese medicine composition and preparation method thereof for treating Alzheimer disease
Technical field
The present invention relates to Chinese medicine compositions, and in particular, to a kind of for treating the Chinese medicine composition of Alzheimer disease And preparation method thereof.
Background technique
Alzheimer disease (AD) is a kind of nervous system degenerative disease of the progress sexual development of onset concealment.Clinically With memory disorders, aphasia, appraxia, agnosia, the damage of visual space technical ability, execute dysfunction and personality and behavior change etc. comprehensively Property dementia performance be characterized, the cause of disease is unknown so far.Patient was sent out before 65 years old, claimed alzheimer's disease；Hair patient claims always after 65 years old Year property is dull-witted.Currently, the therapeutic agent type in clinical practice for senile dementia is fairly limited, it is substantially exactly several small points Sub- chemicals are treated the conventional medicine of senile dementia and are largely directed into the drug of clinical three phases in the world at present Single medicine target is intervened, and curative effect also carries out limited alleviation primarily with respect to the symptoms such as amnesia or nerve fiber degeneration Compensation, therapeutic effect is very limited, and a kind of drug easily generates tolerance after a period of use, and alternative drugs lack It is weary.Therefore currently there is an urgent need to develop the drug that can prevent, treat to significant effective even reverse disease progression, especially Chinese medicine composition.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine compositions and preparation method thereof for treating Alzheimer disease, mention The preparation method of the Chinese medicine composition of confession is simple, raw material is easy to get, while therapeutic effect is good, without side-effects.
To achieve the goals above, the present invention provides a kind of for treating the system of the Chinese medicine composition of Alzheimer disease Preparation Method, the preparation method include：
(1) Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, later respectively for the first time It decocts and second decocts, filtered fluid M is obtained after filtering；
Wherein, the time decocted for the first time is 10-30min；Second of the time decocted is 40-50min；It decocts for the first time Interval time between second of decoction is 20-25min；
(2) rheum officinale, cordyceps sinensis, Radix Polygalae, Flos Albiziae, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are mixed laggard Row grinding, obtains mixed-powder N；
(3) by tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, mixture A is obtained, by mixture A The Chinese medicine composition is obtained after sterilized, dry.
The present invention also provides a kind of for treating the Chinese medicine composition of Alzheimer disease, described for treating A Erci The Chinese medicine composition of the silent disease in sea is made by above-mentioned preparation method.
Through the above technical solutions, the present invention provides a kind of for treating the system of the Chinese medicine composition of Alzheimer disease Preparation Method, the preparation method include：Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, it It decocts for the first time respectively afterwards and second decocts, filtered fluid M is obtained after filtering；Wherein, the time decocted for the first time is 10- 30min；Second of the time decocted is 40-50min；Interval time between decocting and decocting for the first time for second is 20- 25min；It is ground after rheum officinale, cordyceps sinensis, Radix Polygalae, Flos Albiziae, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are mixed Mill, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix Close object A it is sterilized, it is dry after obtain the Chinese medicine composition；The preparation method of the Chinese medicine composition of offer is simple, raw material is easy to get, The therapeutic effect of the Chinese medicine composition is good simultaneously, without side-effects.
Other features and advantages of the present invention will the following detailed description will be given in the detailed implementation section.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more New numberical range, these numberical ranges should be considered as specific open herein.
The present invention provides a kind of for treating the preparation method of the Chinese medicine composition of Alzheimer disease, the preparation side Method includes：
(1) Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, later respectively for the first time It decocts and second decocts, filtered fluid M is obtained after filtering；
Wherein, the time decocted for the first time is 10-30min；Second of the time decocted is 40-50min；It decocts for the first time Interval time between second of decoction is 20-25min；
(2) rheum officinale, cordyceps sinensis, Radix Polygalae, Flos Albiziae, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are mixed laggard Row grinding, obtains mixed-powder N；
(3) by tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, mixture A is obtained, by mixture A The Chinese medicine composition is obtained after sterilized, dry.
In a preferred embodiment of the invention, in order to improve the curative effect of Chinese medicine composition, relative to 100 weight The water of part, the dosage of Huang Shi are 10-15 parts by weight, and the dosage of rhizoma polygonati is 5-8 parts by weight, and the dosage of Fructus Corni is 2-6 parts by weight, The dosage of cortex cinnamomi is 1-7 parts by weight, and the dosage of the tuber of dwarf lilyturf is 2-7 parts by weight, and the dosage of Asian puccoon is 2-10 parts by weight, Herba Cistanches Dosage is 1-6 parts by weight.
In a preferred embodiment of the invention, in order to improve the curative effect of Chinese medicine composition, relative to 100 weight The rheum officinale of part, the dosage of cordyceps sinensis are 20-40 parts by weight, and the dosage of Radix Polygalae is 8-12 parts by weight, and the dosage of Flos Albiziae is 2-8 Parts by weight, the dosage of Poria cocos are 10-20 parts by weight, and the dosage of dendrobium nobile is 5-15 parts by weight, and the dosage of Eclipta prostrata is 2-9 weight Part, the dosage of Radix Notoginseng is 1-10 parts by weight, and the dosage of honeysuckle is 1-10 parts by weight.
In a preferred embodiment of the invention, in order to improve the curative effect of Chinese medicine composition, tortoise-shell glue, filtered fluid M and mixed-powder N is 1 according to mass ratio:0.5-0.7:The ratio of 0.9-1.2 is mixed.
In a preferred embodiment of the invention, in order to improve the curative effect of Chinese medicine composition, in step (3), The condition of sterilizing includes that temperature is 110-115 DEG C, time 5-10min.
In a preferred embodiment of the invention, in order to improve the curative effect of Chinese medicine composition, in step (3), Dry condition includes：Pressure is -0.07Mpa~-0.06Mpa, and temperature is 60-80 DEG C, time 2-3h.
In a preferred embodiment of the invention, in order to improve the curative effect of Chinese medicine composition, mixed-powder N's is flat Equal partial size is 2-4mm.
The present invention also provides a kind of for treating the Chinese medicine composition of Alzheimer disease, described for treating A Erci The Chinese medicine composition of the silent disease in sea is made by above-mentioned preparation method.
The present invention will be described in detail by way of examples below.
Embodiment 1
Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, decocted for the first time respectively later It is decocted with second, filtered fluid M is obtained after filtering；Wherein, the time decocted for the first time is 10min；Second of the time decocted For 40min；Interval time between decocting and decocting for the first time for second is 20min；By rheum officinale, cordyceps sinensis, Radix Polygalae, silk tree Flower, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are 1 according to mass ratio:0.5:0.9 ratio is ground after being mixed Mill, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix Close that object A sterilized (condition of sterilizing includes that temperature is 110 DEG C, time 5min), dry (dry condition includes：Pressure be- 0.07Mpa, temperature be 60 DEG C, time 2h) after obtain the Chinese medicine composition.Wherein, relative to the water of 100g, the use of Huang Shi Amount is 10g, and the dosage of rhizoma polygonati is 5g, and the dosage of Fructus Corni is 2g, and the dosage of cortex cinnamomi is 1g, and the dosage of the tuber of dwarf lilyturf is 2g, Asian puccoon Dosage be 2g, the dosages of Herba Cistanches is 1g；Relative to the rheum officinale of 100g, the dosage of cordyceps sinensis is 20g, and the dosage of Radix Polygalae is 8g, the dosage of Flos Albiziae are 2g, and the dosage of Poria cocos is 10g, and the dosage of dendrobium nobile is 5g, and the dosage of Eclipta prostrata is 2g, the use of Radix Notoginseng Amount is 1g, and the dosage of honeysuckle is 1g.
Embodiment 2
Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, decocted for the first time respectively later It is decocted with second, filtered fluid M is obtained after filtering；Wherein, the time decocted for the first time is 30min；Second of the time decocted For 50min；Interval time between decocting and decocting for the first time for second is 25min；By rheum officinale, cordyceps sinensis, Radix Polygalae, silk tree Flower, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are 1 according to mass ratio:0.7:1.2 ratio is ground after being mixed Mill, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix Close that object A sterilized (condition of sterilizing includes that temperature is 115 DEG C, time 10min), dry (dry condition includes：Pressure For -0.06Mpa, temperature is 80 DEG C, time 3h) after obtain the Chinese medicine composition.Wherein, relative to the water of 100g, Huang Shi Dosage be 15g, the dosage of rhizoma polygonati is 8g, and the dosage of Fructus Corni is 6g, and the dosage of cortex cinnamomi is 7g, and the dosage of the tuber of dwarf lilyturf is 7g, The dosage of Asian puccoon is 10g, and the dosage of Herba Cistanches is 6g；Relative to the rheum officinale of 100g, the dosage of cordyceps sinensis is 40g, Radix Polygalae Dosage is 12g, and the dosage of Flos Albiziae is 8g, and the dosage of Poria cocos is 20g, and the dosage of dendrobium nobile is 15g, and the dosage of Eclipta prostrata is 9g, The dosage of Radix Notoginseng is 10g, and the dosage of honeysuckle is 10g.
Embodiment 3
Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, decocted for the first time respectively later It is decocted with second, filtered fluid M is obtained after filtering；Wherein, the time decocted for the first time is 20min；Second of the time decocted For 45min；Interval time between decocting and decocting for the first time for second is 22min；By rheum officinale, cordyceps sinensis, Radix Polygalae, silk tree Flower, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle are 1 according to mass ratio:0.6:1 ratio is ground after being mixed, Obtain mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix Object A sterilized (condition of sterilizing includes that temperature is 112 DEG C, time 7min), dry (dry condition includes：Pressure be- 0.06Mpa, temperature be 70 DEG C, time 2.5h) after obtain the Chinese medicine composition.Wherein, relative to the water of 100g, Huang Shi's Dosage is 12g, and the dosage of rhizoma polygonati is 7g, and the dosage of Fructus Corni is 4g, and the dosage of cortex cinnamomi is 4g, and the dosage of the tuber of dwarf lilyturf is 4.5g, The dosage of Asian puccoon is 6g, and the dosage of Herba Cistanches is 3.5g；Relative to the rheum officinale of 100g, the dosage of cordyceps sinensis is 30g, Radix Polygalae Dosage is 10g, and the dosage of Flos Albiziae is 5g, and the dosage of Poria cocos is 15g, and the dosage of dendrobium nobile is 10g, and the dosage of Eclipta prostrata is 5.5g, the dosage of Radix Notoginseng are 5.5g, and the dosage of honeysuckle is 5.5g.
Chinese medicine composition made from embodiment 3 is used for clinical treatment, and carries out clinical observation：
Patients of senile dementia 100 made a definite diagnosis are randomly selected.Wherein, male patient 66, female patient 34, Age 60-80 years old, course of disease 1-3.
Treatment method：
Using Chinese medicine composition prepared by the embodiment of the present invention 3, each two panels, three times a day, every content of dispersion 0.25 Gram, half an hour warm water delivery service, avoids pungent greasy object, avoids tobacco and wine after meal；Pregnant woman is used with caution.
Efficacy assessment standard：
It cures：Knowing reduces with memory function decline, social adaptation, and the symptoms such as various mental symptoms and behavior disorder disappear Lose, more after do not recur, completely recovery normal life.
Effectively：Above-mentioned symptom is substantially reduced, and disease cycle increases, and returns to normal life.
It is effective：Above-mentioned symptom mitigates.
In vain：Comparison is checked before and after treatment, and symptom, sign are unchanged.
Case 1, Mr. Wang, male, 71 years old.With symptoms such as failure of memory, insomnia forgetfulness, the embodiment of the present invention is continuously taken The symptom mitigation after 1 month of 3 gained Chinese medicine compositions, symptom disappears after then taking 2 months, is discontinued after continuing medication 3 months, with Visit is not recurred.
Case 2, week certain, female, 62 years old.With lather, kick up a great deal of fuss about, it is suspicious to worry too much, it cannot independently carry out outgoing work Symptoms, once used several western medicines in treatment, the effect such as dynamic are undesirable.Medication process and effect：Take 3 institute of the embodiment of the present invention Symptom mitigates after obtaining Chinese medicine composition 1 month, and symptom disappears after then taking 6 months, is discontinued, and follow-up is not recurred.
Case 3, Zhu, female, 68 years old.Have, unstable on foot, hemiplegia, the symptoms such as gatism once repeatedly toss about training Hospital's unsatisfactory curative effect.Medication process and effect：The symptom mitigation after 2 months of 3 gained Chinese medicine composition of the embodiment of the present invention is taken, with After take 6 months after symptom disappear, continue medication 3 months after be discontinued, follow-up is not recurred.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally The thought of invention, it should also be regarded as the disclosure of the present invention.

Claims (8)

1. a kind of for treating the preparation method of the Chinese medicine composition of Alzheimer disease, which is characterized in that the preparation method Including：
(1) Huang Shi, rhizoma polygonati, Fructus Corni, cortex cinnamomi, the tuber of dwarf lilyturf, Asian puccoon, Herba Cistanches and water are mixed, is decocted for the first time respectively later It is decocted with second, filtered fluid M is obtained after filtering；
Wherein, the time decocted for the first time is 10-30min；Second of the time decocted is 40-50min；It decocts for the first time and the Interval time between secondary decoction is 20-25min；
(2) it is ground after mixing rheum officinale, cordyceps sinensis, Radix Polygalae, Flos Albiziae, Poria cocos, dendrobium nobile, Eclipta prostrata, Radix Notoginseng and honeysuckle Mill, obtains mixed-powder N；
(3) by tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, mixture A is obtained, by mixture A through going out The Chinese medicine composition is obtained after bacterium, drying.
2. preparation method according to claim 1, wherein relative to the water of 100 parts by weight, the dosage of Huang Shi is 10-15 Parts by weight, the dosage of rhizoma polygonati are 5-8 parts by weight, and the dosage of Fructus Corni is 2-6 parts by weight, and the dosage of cortex cinnamomi is 1-7 parts by weight, wheat The dosage in door winter is 2-7 parts by weight, and the dosage of Asian puccoon is 2-10 parts by weight, and the dosage of Herba Cistanches is 1-6 parts by weight.
3. preparation method according to claim 1, wherein relative to the rheum officinale of 100 parts by weight, the dosage of cordyceps sinensis is 20-40 parts by weight, the dosage of Radix Polygalae are 8-12 parts by weight, and the dosage of Flos Albiziae is 2-8 parts by weight, and the dosage of Poria cocos is 10-20 Parts by weight, the dosage of dendrobium nobile are 5-15 parts by weight, and the dosage of Eclipta prostrata is 2-9 parts by weight, and the dosage of Radix Notoginseng is 1-10 parts by weight, The dosage of honeysuckle is 1-10 parts by weight.
4. preparation method according to claim 1, wherein tortoise-shell glue, filtered fluid M and mixed-powder N are according to mass ratio 1:0.5-0.7:The ratio of 0.9-1.2 is mixed.
5. preparation method according to claim 1, wherein in step (3), the condition of sterilizing includes that temperature is 110- 115 DEG C, time 5-10min.
6. preparation method according to claim 1, wherein in step (3), dry condition includes：Pressure be- 0.07Mpa~-0.06Mpa, temperature are 60-80 DEG C, time 2-3h.
7. preparation method according to claim 1, wherein the average grain diameter of mixed-powder N is 2-4mm.
8. a kind of for treating the Chinese medicine composition of Alzheimer disease, which is characterized in that described for treating Alzheimer Chinese medicine composition preparation method as described in any one of claim 1-7 of disease is made.
CN201810767567.XA 2018-07-13 2018-07-13 Chinese medicine composition and preparation method thereof for treating Alzheimer disease Pending CN108815371A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103071048A (en) * 2013-02-07 2013-05-01 贵州神奇投资有限公司 Traditional Chinese medicine composition for treating alzheimer diseases and preparation method of traditional Chinese medicine composition
CN104162082A (en) * 2014-08-13 2014-11-26 高丽丽 Traditional Chinese medicine for treating senile dementia and preparation method of fluid extract of traditional Chinese medicine
CN105521306A (en) * 2015-12-09 2016-04-27 贵州神奇药物研究院 Traditional Chinese medicine composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103071048A (en) * 2013-02-07 2013-05-01 贵州神奇投资有限公司 Traditional Chinese medicine composition for treating alzheimer diseases and preparation method of traditional Chinese medicine composition
CN104162082A (en) * 2014-08-13 2014-11-26 高丽丽 Traditional Chinese medicine for treating senile dementia and preparation method of fluid extract of traditional Chinese medicine
CN105521306A (en) * 2015-12-09 2016-04-27 贵州神奇药物研究院 Traditional Chinese medicine composition

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