CN108815226A - A kind of gynemetrics's drug and preparation method thereof for treating endocrine disorder - Google Patents

A kind of gynemetrics's drug and preparation method thereof for treating endocrine disorder Download PDF

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CN108815226A
CN108815226A CN201810862513.1A CN201810862513A CN108815226A CN 108815226 A CN108815226 A CN 108815226A CN 201810862513 A CN201810862513 A CN 201810862513A CN 108815226 A CN108815226 A CN 108815226A
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parts
rhizome
drug
gynemetrics
filtrate
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王玉红
张全乐
赵淑珍
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First Affiliated Hospital of Xinxiang Medical University
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First Affiliated Hospital of Xinxiang Medical University
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Abstract

The invention discloses a kind of gynemetrics's drugs for treating endocrine disorder, belong to pharmaceutical technology field.The drug is made of raw material from the following weight：8-15 parts of Radix Astragali, 10-15 parts of rhizome of chuanxiong, 8-12 parts of myrrh, 10-15 parts of teasel root, 2-5 parts of radix glycyrrhizae preparata, 5-8 parts of olibanum, 3-8 parts of PORIA ALBA, 5-10 parts of walnut kernel, 8-12 parts of Fructus Liquidambaris, 5-10 parts of the rhizome of davallia, 3-6 parts of lopseed.Gynemetrics's drug for the treatment of endocrine disorder of the invention has effects that replenishing vital essence and invigorating vital QI, blood circulation promoting and enriching, moistening the lung and nourish yin, has significant and prolonged curative effect, without side-effects, enables patients blood unobstructed, treating both manifestation and root cause of disease, and recurrence rate is low.

Description

A kind of gynemetrics's drug and preparation method thereof for treating endocrine disorder
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of gynemetrics's drug for treating endocrine disorder and its preparation Method.
Background technique
Human body has endocrine system, secretes metabolism and physiological function that various hormones and nervous system adjust human body together. Various hormones are to maintain balance under normal circumstances, if will result in interior point because certain reason breaks this balance Secrete imbalance.From the point of view of in Chinese medicine, it is as caused by stagnation of QI-blood that endocrine disorder, which is the performance of the deficiency of Yin,.Many common of women Disease is due to caused by endocrine disorder.The youthful vigor and appearance skin of women and kidney, ovarian function and hormone Balance etc. is directly related.Endocrine disorder will lead to women occur pachylosis, have a dizzy spell, trick is powerless, anaemia and stomach and intestine The illnesss such as tract disease.It needs to supplement in right amount and improves kidney, ovarian function and the substance for adjusting estrogen and androgen balance, make tired in vivo The organ and organized renewing vigor that labor, vigor decline, such body just can be more young healthy.
Therefore, these illnesss are treated, to be started with from endocrine is adjusted, be enabled qi and blood unobstructed, essence and blood is allowed to nourish whole body, promote blood Liquid circulation, comprehensive conditioning from inside to outside.
Summary of the invention
The present invention provides a kind of gynemetrics's drug for treating endocrine disorder, can solve in the prior art above-mentioned ask Topic.
The present invention provides a kind of gynemetrics's drugs for treating endocrine disorder, are made of raw material from the following weight：It is yellow 8-15 parts of stilbene, 10-15 parts of rhizome of chuanxiong, 8-12 parts of myrrh, 10-15 parts of teasel root, 2-5 parts of radix glycyrrhizae preparata, 5-8 parts of olibanum, PORIA ALBA 3-8 Part, 5-10 parts of walnut kernel, 8-12 parts of Fructus Liquidambaris, 5-10 parts of the rhizome of davallia, 3-6 parts of lopseed.
Preferably, the drug is made of raw material from the following weight：12 parts of Radix Astragali, 12 parts of rhizome of chuanxiong, 11 parts of myrrh, teasel root 12 Part, 2 parts of radix glycyrrhizae preparata, 5 parts of olibanum, 4 parts of PORIA ALBA, 6 parts of walnut kernel, 10 parts of Fructus Liquidambaris, 8 parts of the rhizome of davallia, 5 parts of lopseed.
Preferably, the drug is made of raw material from the following weight：10 parts of Radix Astragali, 10 parts of rhizome of chuanxiong, 10 parts of myrrh, teasel root 12 Part, 3 parts of radix glycyrrhizae preparata, 6 parts of olibanum, 5 parts of PORIA ALBA, 8 parts of walnut kernel, 8 parts of Fructus Liquidambaris, 8 parts of the rhizome of davallia, 3 parts of lopseed.
Preferably, the drug is made of raw material from the following weight：15 parts of Radix Astragali, 15 parts of rhizome of chuanxiong, 12 parts of myrrh, teasel root 10 Part, 5 parts of radix glycyrrhizae preparata, 8 parts of olibanum, 8 parts of PORIA ALBA, 10 parts of walnut kernel, 12 parts of Fructus Liquidambaris, 5 parts of the rhizome of davallia, 6 parts of lopseed.
The present invention provides the preparation methods of gynemetrics's drug of the treatment endocrine disorder, include the following steps：
Step 1：By each raw material drying, to be crushed to 80-120 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, mixes, 8-10 times of total powder weight is then added Water, impregnate 2-4 hour, be heated to boiling, heat preservation 0.5-2 hours, filter to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 0.5~5 times of water of total powder weight, decocts 0.5~2 hour, Filtering obtains filtrate, merges filtrate twice, and filtrate is concentrated to the 30-80% of front volume for it, is cooled to 50-65 DEG C to filtrate, The ethyl alcohol of the filtrate volume 40~60% after accounting for concentration is added, alcohol precipitation is carried out, ethyl alcohol is recovered under reduced pressure after standing 48 hours；
Step 4：It is 1.08-1.18 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains medicinal extract.
The pharmacology of each raw material in drug provided by the invention is as follows：
Radix Astragali：Bitter, cold in nature, return heart, lung, stomach, gallbladder, large intestine channel have tonifying Qi and lifting yang, invigorating qi for consolidating superficies, promoting pus discharge and tissue regeneration, benefit The effect of water is reduced swelling cures mainly damp and hot caused diarrhea, dysentery, jaundice, heat gonorrhea；Cough with lung heat, thirsty pharyngalgia, it may also be used for tire heat Uneasiness, heat toxin fire-evil invade the disease that the sore carbuncle poison of excessive skin swells.And specific cellular immunity non-specific to body has enhancing to make With can be improved T cell proliferative capacity, promote macrophage activation, Radix Astragali can stop night sweat, accelerate that lesion absorbs and cavity is cured It closes, improve sputum negative conversion rate, and the toxic side effect of Antituberculous Drugs has apparent antagonism.
Rhizome of chuanxiong：Property is acrid in flavour and warm in nature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.
Myrrh：Acrid flavour, hardship, it is mild-natured.Return heart, liver, the spleen channel.Scattered stasis pain, detumescence and promoting granulation.For chest impediment and cardialgia, pain of gastric cavity Bitterly, dysmenorrhea menostasis postpartum stasis , abdominal mass and abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the illnesss such as carbuncle swells sore.
Teasel root：It is warm-natured, it is bitter, pungent, have nourishing liver and kidney, strengthening the bones and muscles, continuous injured, only metrorrhagia and metrostaxis the effect of, can be used for treating waist and knee Aching and limp, rheumatic arthralgia, metrorrhagia and metrostaxis, vaginal bleeding during pregnancy, the illness of injury from falling down.
Radix glycyrrhizae preparata：Containing a variety of chemical components such as glycyrrhizin, enoxolone, licorice polysaccharide, there is anti-inflammatory and resistance state Body's immunity, antitumor and analgesic effect is adjusted in reagentia.Therefore radix glycyrrhizae preparata primary efficacy be with middle emergency, Moistening lung, removing toxic substances, coordinating the drug actions of a prescription.It is usually used in weakness of the spleen and the stomach, fatigue and weakness, severe palpilation, knotted pulse, detachable son poison.
Olibanum：It is pungent, bitter, temperature.Return heart, liver, the spleen channel.Blood-activating and qi-promoting analgesic, detumescence and promoting granulation.For chest impediment and cardialgia, pain of gastric cavity Bitterly, dysmenorrhea menostasis, postpartum stasis, abdominal mass abdominal pain, rheumatic arthralgia, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.
PORIA ALBA：Nature and flavor are sweet, light, put down.Channel tropism：Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Function：Excreting dampness invigorating the spleen.It cures mainly：Just It is unfavorable；Edema swelling；Sip and cough；Vomiting；Spleen eating less；Diarrhea；Palpitation and restlessness；Insomnia forgetfulness；Spermatorrhea gonorrhoea.Machine can be enhanced Body immunity function, pachymaran have apparent antitumor and liver protecting effect.
Walnut kernel：Nature and flavor sweet, warm.Return kidney, lung, large intestine channel.Kidney tonifying, warm lung, ease constipation.For soreness and weakness of waist and knees, impotence and seminal emission, Cold of insufficiency type asthma is coughed, constipation.
Fructus Liquidambaris：Hardship is put down.Return liver and kidney channel.Dispelling, collateral-activating, Li Shui stimulates the menstrual flow.For arthralgia, numbness contracture, oedema is swollen It is full, the few menostasis of cream.
The rhizome of davallia：Hardship, temperature.Enter liver and kidney channel.Kidney tonifying is invigorated blood circulation, hemostasis.Control kidney deficiency chronic diarrhea and pain in the loins, rheumatic arthralgia, dentalgia, Tinnitus, the bruise sudden strain of a muscle, bone fracture, ecphyaditis, alopecia areata, corn.
Lopseed：Sweet, acrid, warm.Enter lung, liver two passes through.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, solution poison rash.
Compared with prior art, the beneficial effects of the invention are as follows：Gynemetrics's drug for the treatment of endocrine disorder of the invention Have effects that replenishing vital essence and invigorating vital QI, blood circulation promoting and enriching, moistening the lung and nourish yin, there is significant and prolonged curative effect, it is without side-effects, enable patient's gas Blood is unobstructed, treating both manifestation and root cause of disease, and recurrence rate is low.
Specific embodiment
Specific embodiments of the present invention will be described in detail below, it is to be understood that protection scope of the present invention is not It is restricted by specific implementation.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creativeness Every other embodiment obtained, shall fall within the protection scope of the present invention under the premise of labour.
Embodiment 1：
A kind of gynemetrics's drug for treating endocrine disorder provided by the invention, is made of raw material from the following weight：It is yellow 12 parts of stilbene, 12 parts of rhizome of chuanxiong, 11 parts of myrrh, 12 parts of teasel root, 2 parts of radix glycyrrhizae preparata, 5 parts of olibanum, 4 parts of PORIA ALBA, 6 parts of walnut kernel, Lu Lu Lead to 10 parts, 8 parts of the rhizome of davallia, 5 parts of lopseed.
Embodiment 2：
A kind of gynemetrics's drug for treating endocrine disorder provided by the invention, is made of raw material from the following weight：It is yellow 10 parts of stilbene, 10 parts of rhizome of chuanxiong, 10 parts of myrrh, 12 parts of teasel root, 3 parts of radix glycyrrhizae preparata, 6 parts of olibanum, 5 parts of PORIA ALBA, 8 parts of walnut kernel, Lu Lu Lead to 8 parts, 8 parts of the rhizome of davallia, 3 parts of lopseed.
Embodiment 3：
A kind of gynemetrics's drug for treating endocrine disorder provided by the invention, is made of raw material from the following weight：It is yellow 15 parts of stilbene, 15 parts of rhizome of chuanxiong, 12 parts of myrrh, 10 parts of teasel root, 5 parts of radix glycyrrhizae preparata, 8 parts of olibanum, 8 parts of PORIA ALBA, 10 parts of walnut kernel, Lu Lu Lead to 12 parts, 5 parts of the rhizome of davallia, 6 parts of lopseed.
Embodiment 4：
The present invention provides the preparation methods of said medicine, include the following steps：
Step 1：By each raw material drying, to be crushed to 80 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, mixes, 10 times of total powder weight are then added Water impregnates 3 hours, is heated to boiling, and keeps the temperature 1 hour, filters to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 4 times of water of total powder weight, decocts 1 hour, and filtering is filtered Liquid merges filtrate twice, and 50% of the filtrate volume after filtrate concentration is merged, 65 DEG C are cooled to filtrate, adds and accounts for The ethyl alcohol of filtrate volume 55% after concentration carries out alcohol precipitation, and ethyl alcohol is recovered under reduced pressure after standing 48 hours；
Step 4：It is 1.13 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains medicinal extract.
Embodiment 5：
The present invention provides the preparation methods of said medicine, include the following steps：
Step 1：By each raw material drying, to be crushed to 80-120 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, mixes, 9 times of total powder weight are then added Water impregnates 3.5 hours, is heated to boiling, and keeps the temperature 1.5 hours, filters to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 2 times of water of total powder weight, decocts 1.5 hours, and filtering obtains Filtrate merges filtrate twice, and 40% of the filtrate volume after filtrate concentration is merged, 60 DEG C are cooled to filtrate, is added The ethyl alcohol of filtrate volume 50% after accounting for concentration carries out alcohol precipitation, and ethyl alcohol is recovered under reduced pressure after standing 48 hours；
Step 4：It is 1.14 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains medicinal extract.
The oral solution, granule and tablet medically approved can be made in said medicine further according to conventional method Deng no longer elaborating herein.
Clinical application test
In order to verify treatment endocrine disorder of the invention gynemetrics's drug therapeutic effect, we choose 200 trouble There is the women of endocrine disorder as test group, takes drug made from the embodiment of the present invention 1, three times a day, 5 grams every time, even It is continuous to take 10 days as a treatment course, continuously take 4 course for the treatment of.Control group is treated using conventional hormonal medicaments, illustratively Book is taken, and continuously takes 4 course for the treatment of.
Criterion of therapeutical effect
1, it cures：Clinical symptoms, sign disappear, without recurrence after follow-up 1 year；
2, effective：Clinical symptoms, sign are substantially reduced；
3, effectively：Clinical symptoms, sign mitigate, and seizure frequency is reduced, and the breaking-out duration shortens；
4, invalid：Clinical symptoms, sign without improvement or aggravate.
Test result is as shown in table 1：
1 test group of table and control group test result
Cure number of cases/example Effective number of cases/example Effective number of cases/example Invalid number of cases/example
Test group 58 32 5 5
Control group 32 27 12 29
Above-mentioned experiment results proved drug therapy endocrine disorder provided by the invention is significant in efficacy, has and promotes well Value.
There is provided several typical cases separately to illustrate beneficial effects of the present invention.
Case 1：Patient, women, 33 years old, since before 3 years there are chest distress and palpitation symptoms, irregular menstruation, feel depressed, be easy Night sweat.It is endocrine disorder through tcm diagnosis, after taking 2 courses for the treatment of of drug of the embodiment of the present invention 2, situation takes a favorable turn, Continue after taking 2 course for the treatment of, the above symptom all disappears, and follow-up 1 year, no recurrence, body was without impaired.
Case 2：Patient, women 40 years old, become coarse since the skin before 2 years, matt, facial withered and yellow, dizzy mesh It is dizzy, loss of appetite.It is endocrine disorder through tcm diagnosis, after taking 4 courses for the treatment of of drug of the embodiment of the present invention 3, situation is big It take a favorable turn, continues after taking 2 course for the treatment of, the above symptom all disappears, and follow-up 1 year, no recurrence, body was without impaired.
Case 3：Patient, women, diet is irregular before 45 years old, patient's readme 2 years, loss of appetite, bad, body of sleeping Tired, hair starts shedding off.It is endocrine disorder through tcm diagnosis, after taking 3 courses for the treatment of of drug of the embodiment of the present invention 1, Situation takes a favorable turn, and continues after taking 2 course for the treatment of, and the above symptom all disappears, and follow-up 1 year, no recurrence, body was without impaired.
Gynemetrics's drug for the treatment of endocrine disorder of the invention have replenishing vital essence and invigorating vital QI, blood circulation promoting and enriching, moistening the lung and nourish yin function Effect has significant and prolonged curative effect, without side-effects, enables patients blood unobstructed, treating both manifestation and root cause of disease, and recurrence rate is low.
In order to prove the safety of Chinese medicine preparation of the invention, spy makes zoopery, notes at foot：
Zoopery
1 experiment purpose
To the Traditional Chinese medicine composition formula of embodiment 1, weigh Radix Astragali, rhizome of chuanxiong, myrrh, teasel root, radix glycyrrhizae preparata, olibanum, PORIA ALBA, Walnut kernel, Fructus Liquidambaris, the rhizome of davallia, lopseed, crush respectively, are uniformly mixed, powder are then conventionally made, and to it Acute toxicity makes evaluation, provides experimental basis for data for clinical drug use.
2 experimental materials
2.1 test medicine：The Traditional Chinese medicine composition formula of embodiment 1 weighs Radix Astragali, rhizome of chuanxiong, myrrh, teasel root, radix glycyrrhizae preparata, cream Perfume, PORIA ALBA, walnut kernel, Fructus Liquidambaris, the rhizome of davallia, lopseed crush respectively, be uniformly mixed obtain medicinal mixture, then according to Powder is made in conventional method.
2.2 experimental animal：Kun Ming mice, weight 20g-25g, half male and half female, by Heilongjiang University of Chinese Medicine animal Experimental center provides.
The preparation of 2.3 laboratory samples：A certain amount of powder is weighed, is put into mortar and is ground into fine powder, water is added to mix well, is made Certain density drug suspension.Dosage is calculated by the fine drug powder weight of the every kg body weight of animal.
2.4 method
2.4.1 trial test：20 mouse are randomly divided into 2 groups, every group 10, half male and half female, ig is administered after fasting 16h. Administration group mouse with biggest quality concentration (0.6g/mL), ig administration can bear maximum volume (40mL/kg), 2 minor tick 6h to Give drug suspension.Blank group ig equal amount of distilled water.Successive administration 14 days, whole mouse survivals, failed to measure this as the result is shown Tested material LD50 value prompts the tested material toxicity very low, foundation《Chinese medicine, natural drug studies on acute toxicity technological guidance's principle》 Use maximum dosage-feeding administration instead.
2.4.2 the measurement of maximum dosage-feeding：It presses mass of object to divide at random 2 groups (administration group and control groups), every group 30, Half male and half female.After fasting 16h, mouse ig gives tested material biggest quality concentration 0.6g/mL and maximum ig administration volume 40mL/ Kg, daily ig are administered 2 times, are spaced 6h.Blank group ig equal amount of distilled water.It is observed continuously in 4h after administration, daily morning and afternoon is respectively seen It examines 1 time, is observed continuously 14 days.Observe animal body quality, the state of mind, hair color, autonomic activities, breathing, diet, two just, mouth and nose The general states such as secretion, and the appearance of record symptom, recovery and death time in detail.Weight measurement：Buy day, animal packet When, measured 1 time every 2 days after administration, when animal dissect, measures 1 time.Entire off-test next day animal dislocation is put to death, and is carried out Dissection.Animal appearance, each internal organs of whole body are visually observed when dissect, make histopathological examination if noting abnormalities.
2.4.3 all data of data processing are indicated with (x ± s), and comparison among groups are examined using t, are carried out using SPSS17.0 Data analysis.
3 experimental results
The influence of 3.1 pairs of mouse weights
Groups of animals is to when off-test before test, and not shown difference trend out, each animal subject weight is in one The growth for determining degree illustrates the growth for not influencing animal subject after tested material ig is administered, the results are shown in Table 3, table 4.
3.2 toxic reaction
From the administration same day up to off-test, mouse is in good condition, and activity and diet are acted normally, and hair frontlighting is bright, Formed stools do not occur animal dead situation, also do not observe apparent abnormal response situation.
Calculating and always giving within 24 hours dose is 16g/kg, and adult (pressing 70kg batheroom scale) clinical day dosage is 10g/ 70kg (i.e. 0.43g/kg) extrapolates being equivalent to the multiple (multiple=48/0.43=111 times) of clinical day dosage and be greater than 100 times, show that the Chinese medicine composition toxicity is lower, safe range is big.
The influence of 3.3 pairs of mouse Histopathology
Off-test next day, all animals have carried out gross anatomy observation, and naked eyes do not find that volume, face occurs in organ Color, quality etc. change.Especially observe the important organs such as brain, the heart, liver, spleen, lung, kidney, have no bleeding, hyperemia, exudation, ulcer, Perforation, inflammation, thoracic cavity, abdominal cavity and cavum pericardiale show that the Chinese medicine composition toxicity is lower, safe range is big without hydrops.
Table 3 to male mice weight influence (N=10)
Table 4 to female mice weight influence (N=20)
Disclosed above is only several specific embodiments of the invention, and still, the embodiment of the present invention is not limited to this, is appointed What what those skilled in the art can think variation should all fall into protection scope of the present invention.

Claims (5)

1. a kind of gynemetrics's drug for treating endocrine disorder, which is characterized in that be made of raw material from the following weight：Radix Astragali 8- 15 parts, 10-15 parts of rhizome of chuanxiong, 8-12 parts of myrrh, 10-15 parts of teasel root, 2-5 parts of radix glycyrrhizae preparata, 5-8 parts of olibanum, 3-8 parts of PORIA ALBA, core 5-10 parts of peach kernel, 8-12 parts of Fructus Liquidambaris, 5-10 parts of the rhizome of davallia, 3-6 parts of lopseed.
2. gynemetrics's drug for the treatment of endocrine disorder as described in claim 1, which is characterized in that by the original of following parts by weight Material is made：12 parts of Radix Astragali, 12 parts of rhizome of chuanxiong, 11 parts of myrrh, 12 parts of teasel root, 2 parts of radix glycyrrhizae preparata, 5 parts of olibanum, 4 parts of PORIA ALBA, walnut kernel 6 parts, 10 parts of Fructus Liquidambaris, 8 parts of the rhizome of davallia, 5 parts of lopseed.
3. gynemetrics's drug for the treatment of endocrine disorder as described in claim 1, which is characterized in that by the original of following parts by weight Material is made：10 parts of Radix Astragali, 10 parts of rhizome of chuanxiong, 10 parts of myrrh, 12 parts of teasel root, 3 parts of radix glycyrrhizae preparata, 6 parts of olibanum, 5 parts of PORIA ALBA, walnut kernel 8 parts, 8 parts of Fructus Liquidambaris, 8 parts of the rhizome of davallia, 3 parts of lopseed.
4. gynemetrics's drug for the treatment of endocrine disorder as described in claim 1, which is characterized in that by the original of following parts by weight Material is made：15 parts of Radix Astragali, 15 parts of rhizome of chuanxiong, 12 parts of myrrh, 10 parts of teasel root, 5 parts of radix glycyrrhizae preparata, 8 parts of olibanum, 8 parts of PORIA ALBA, walnut kernel 10 parts, 12 parts of Fructus Liquidambaris, 5 parts of the rhizome of davallia, 6 parts of lopseed.
5. the preparation method of gynemetrics's drug of the treatment endocrine disorder as described in claim 1-4 is any, which is characterized in that Include the following steps：
Step 1：By each raw material drying, to be crushed to 80-120 mesh powder spare；
Step 2：The powder of each raw material is weighed by weight, mixes, 8-10 times of water of total powder weight is then added, It impregnates 2-4 hours, is heated to boiling, keep the temperature 0.5-2 hours, filter to get filtrate, isolate filter residue；
Step 3：The filter residue that step 2 is collected adds 0.5~5 times of water of total powder weight, decocts 0.5~2 hour, filtering, It obtains filtrate, merges filtrate twice, by the 30-80% of filtrate concentration front volume for it, be cooled to 50-65 DEG C to filtrate, then plus Enter the ethyl alcohol of the filtrate volume 40~60% after accounting for concentration, carry out alcohol precipitation, ethyl alcohol is recovered under reduced pressure after standing 48 hours；
Step 4：It is 1.08-1.18 that filtrate after step 3 alcohol precipitation, which is concentrated into relative density, obtains medicinal extract.
CN201810862513.1A 2018-08-01 2018-08-01 A kind of gynemetrics's drug and preparation method thereof for treating endocrine disorder Withdrawn CN108815226A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585354A (en) * 2019-08-07 2019-12-20 宁夏医科大学 Formula and preparation method of substitutional tea for preventing and treating oral ulcer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585354A (en) * 2019-08-07 2019-12-20 宁夏医科大学 Formula and preparation method of substitutional tea for preventing and treating oral ulcer

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