CN108814620A - Flexible physiological information monitoring device - Google Patents

Flexible physiological information monitoring device Download PDF

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Publication number
CN108814620A
CN108814620A CN201810541996.5A CN201810541996A CN108814620A CN 108814620 A CN108814620 A CN 108814620A CN 201810541996 A CN201810541996 A CN 201810541996A CN 108814620 A CN108814620 A CN 108814620A
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China
Prior art keywords
light
detection
component
blood oxygen
oxygen saturation
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CN201810541996.5A
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冯雪
王宙恒
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Tsinghua University
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Tsinghua University
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Priority to CN201810541996.5A priority Critical patent/CN108814620A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Abstract

This disclosure relates to a kind of flexible physiological information monitoring device.The device includes:Light source assembly emits light wave to detected object;Photoelectric detection component obtains first detection signal to optical signal photoelectric conversion of the light wave after detected object reflects;Processing component obtains detection data to first detection signal signal processing;Substrate is fabricated from a flexible material, carrying light source assembly, photoelectric detection component and processing component;Photoelectric detection component includes multiple detection parts around light source assembly arrangement, and the distance between detection part and photoelectric detection component are so that the ratio of the light intensity of the light intensity and light wave of optical signal is greater than or equal to the first distance of first threshold.In accordance with an embodiment of the present disclosure, light wave can be obtained by photoelectric detection component and obtain detection signal after reflection, obtain detection data after signal processing, by the analysis to detection data, can obtain the physiologic information of measurand in real time.

Description

Flexible physiological information monitoring device
Technical field
This disclosure relates to medical detection technology more particularly to a kind of flexible physiological information monitoring device.
Background technique
Detection (such as detection of blood oxygen saturation) to Human Physiology information is the important link in medical treatment.Blood oxygen saturation Degree is one of most important physiology physical sign parameters of human body, is had in fields such as clinical medicine, medical monitoring, medical researches particularly important Reference value.The main means of detection blood oxygen saturation are using finger clip type blood oxygen saturation detector at present, and detection position is generally The positions such as finger, ear-lobe.
As attention rate of the people to own health improves, wearable Medical Devices have more extensive Demand Base, are good for Health Medical Devices become the required consumer goods.The gradually concern by more and more people of non-intrusion type blood oxygen transducer.Current Blood oxygen transducer is all based near infrared light spectral imaging technology, during practical application, generally needs in human motion When long, dynamically monitor the parameters such as blood oxygen, pulse.But since current blood oxygen transducer detection position is limited, therefore to extreme ring The information of blood oxygen is unable to get under border, for example, pilot is in flight course, it is real-time there is an urgent need to be carried out to physical trait parameter Dynamic measures, but current oxygen saturation monitor device can not obtain blood oxygenation information of the pilot in flight course.
Summary of the invention
In view of this, the present disclosure proposes a kind of flexible physiological information monitoring devices.
According to the one side of the disclosure, a kind of flexible physiological information monitoring device is provided, described device includes:Light source group Part, photoelectric detection component, processing component and substrate;
The light source assembly is used to emit light wave to detected object;
The photoelectric detection component is used to carry out photoelectricity to optical signal of the light wave after detected object reflection Conversion obtains first detection signal;
The processing component is used to carry out signal processing to the first detection signal, obtains detection data;
The substrate is fabricated from a flexible material, for carrying the light source assembly, the photoelectric detection component and the place Manage component;
Wherein, the photoelectric detection component includes multiple detection parts around light source assembly arrangement, the multiple The distance between detection part and the photoelectric detection component are first distance, and the first distance is so that the optical signal The ratio of light intensity and the light intensity of the light wave is greater than or equal at a distance from first threshold.
In one possible implementation, the light source assembly include at least two luminous components, described at least two Luminous component emits the light wave of different central wavelengths or different spectral respectively,
Wherein, the processing component is also used to control at least two luminous components of the light source assembly in light period It shines according to predetermined order,
Wherein, the response section of the photoelectric detection component covers in the light emitted wave of at least two luminous components Cardiac wave is long or in the spectral range of the light emitted wave of at least two luminous components.
In one possible implementation, the detection data includes the blood oxygen saturation of detected object, the place It manages component and signal processing is carried out to the first detection signal, obtaining detection data includes:
Analog-to-digital conversion is carried out to multiple first detection signals of the multiple detection part, and carries out summation process, is obtained Digital detection signal;
Calculus of differences is carried out to the digital detection signal, obtains the blood oxygen saturation of each light period;
According to the blood oxygen saturation of each light period, the blood oxygen saturation in first time period is determined.
In one possible implementation, calculus of differences is carried out to the digital detection signal, obtains each shine week The blood oxygen saturation of phase includes:
According to light period pair digital detection signal point corresponding from the light wave of the different central wavelengths or different spectral Not carry out calculus of differences, to obtain the relationship between the amplitude of digital detection signal and hemoglobin concentration;
According to the relationship between the amplitude and hemoglobin concentration of the digital detection signal, each light period is obtained Blood oxygen saturation.
In one possible implementation, it according to the blood oxygen saturation of each light period, determines in first time period Blood oxygen saturation include:The arithmetic average of the blood oxygen saturation of all light periods in first time period is determined as institute State the blood oxygen saturation of detected object.
In one possible implementation, the first distance is determined by Monte-carlo Simulation Method.
In one possible implementation, the photoelectric detection component includes multiple detection parts, the multiple detection Component is respectively positioned on using the position of the light source assembly as the center of circle, using the first distance as on the circle of radius.
In one possible implementation, described device further includes:Encapsulated layer is fabricated from a flexible material, for encapsulating The light source assembly, the photoelectric detection component and the processing component, and engaged with the flexible substrate.
In one possible implementation, described device further includes:Transmitting-receiving subassembly, for sending the detection data To terminal, and receive the instruction of the terminal.
In one possible implementation, described device includes flexible oxygen saturation monitor device, the flexibility oxygen saturation monitor Device is integrated in wearable device, with the blood oxygen saturation of the determination detected object.
According to the flexible physiological information monitoring device of all aspects of this disclosure light source can be obtained by photoelectric detection component The detection signal that the light wave of component transmitting obtains after body reflects is obtaining detection after processing component carries out signal processing Data can obtain the physiologic information of measurand, such as blood oxygen saturation by the analysis and processing to detection data in real time Deng.
According to below with reference to the accompanying drawings to detailed description of illustrative embodiments, the other feature and aspect of the disclosure will become It is clear.
Detailed description of the invention
Comprising in the description and constituting the attached drawing of part of specification and specification together illustrates the disclosure Exemplary embodiment, feature and aspect, and for explaining the principles of this disclosure.
Fig. 1 is the schematic diagram of flexible physiological information monitoring device shown according to an exemplary embodiment;
Fig. 2 is the side sectional view of flexible physiological information monitoring device shown according to an exemplary embodiment;
Fig. 3 is the process that processing component shown according to an exemplary embodiment carries out signal processing to first detection signal Figure;
Fig. 4 is the schematic diagram of the flexible oxygen saturation monitor device shown according to an exemplary embodiment being integrated in the helmet.
Specific embodiment
Various exemplary embodiments, feature and the aspect of the disclosure are described in detail below with reference to attached drawing.It is identical in attached drawing Appended drawing reference indicate element functionally identical or similar.Although the various aspects of embodiment are shown in the attached drawings, remove It non-specifically points out, it is not necessary to attached drawing drawn to scale.
Dedicated word " exemplary " means " being used as example, embodiment or illustrative " herein.Here as " exemplary " Illustrated any embodiment should not necessarily be construed as preferred or advantageous over other embodiments.
In addition, giving numerous details in specific embodiment below to better illustrate the disclosure. It will be appreciated by those skilled in the art that without certain details, the disclosure equally be can be implemented.In some instances, for Method, means, element and circuit well known to those skilled in the art are not described in detail, in order to highlight the purport of the disclosure.
Fig. 1 is the schematic diagram of the flexible physiological information monitoring device shown in an exemplary embodiment.As shown in Figure 1, according to The physiologic information monitoring device of the embodiment of the present disclosure includes light source assembly 11, photoelectric detection component 12, processing component 13 and substrate 14。
Light source assembly 11 is used to emit light wave to detected object;
Photoelectric detection component 12 is used to carry out photoelectric conversion to optical signal of the light wave after detected object reflects, and obtains the One detection signal;
Processing component 13 is used to carry out signal processing to first detection signal, obtains detection data;
Substrate 14 is fabricated from a flexible material, for carrying light source assembly 11, photoelectric detection component 12 and processing component 13;
Wherein, photoelectric detection component 12 includes the multiple detection parts arranged around light source assembly 11, multiple detection parts The distance between photoelectric detection component 11 is first distance, and first distance is light intensity and light source group so that the optical signal of reflection The ratio of the light intensity for the light wave that part 11 emits is greater than or equal to the distance of first threshold.
According to the flexible physiological information monitoring device of the embodiment of the present disclosure, light source group can be obtained by photoelectric detection component The detection signal that the light wave of part transmitting obtains after body reflects is obtaining testing number after processing component carries out signal processing According to the physiologic information of measurand, such as blood oxygen saturation etc. can be obtained in real time by the analysis and processing to detection data.
It for example, may include flexible blood oxygen detection dress according to the flexible physiological information detector of the embodiment of the present disclosure It sets.In the related art, the non-invasive blood oxygen detection based on photoelectric characteristic is with lambert Bill (Beer-Lambert) law For theoretical basis, realized using Their Determination by Spectrophotometry principle.For example, can control the different light source alternating of two beam wavelength It shines, the light wave of generation after site tissue reflection (such as forehead etc.), reaches photoelectric sensor assembly after testing.Wherein, light wave Total light intensity be equal to the summation of the light intensity of detection site tissue resorption, the light intensity of transmission and the light intensity of reflection.Photodetection Component detects the light intensity magnitude reflected after the absorption of hemoglobin et al. substance in vivo, obtains volume wave signal.It is logical It crosses and volume wave signal is analyzed and calculated, the physiologic informations such as pulse and oximetry value can be obtained.
In one possible implementation, light source assembly 11, photoelectric detection component 12 are connected with processing component 13, In example, light source assembly 11, photoelectric detection component 12 can be used flexible wire and connect with processing component 13.
Fig. 2 is the side sectional view of flexible physiological information monitoring device shown according to an exemplary embodiment.Such as Fig. 2 institute Show, the flexible physiological information monitoring device further includes encapsulated layer 15, and encapsulated layer 15 is fabricated from a flexible material, and is used for packaged light source Component 11, photoelectric detection component 12 and processing component 13, and engaged with substrate 14.Light source assembly 11,12 and of photoelectric detection component Processing component 13 is arranged on substrate 14.Substrate 14 can be bi-layer substrate, to carry and cover light source assembly 11, Photoelectric Detection Component 12 and processing component 13.
In one possible implementation, light source assembly 11 includes at least two luminous components, at least two hair Light component emits the light wave of different central wavelengths or different spectral respectively.Luminous component can be light emitting diode (LED), laser Device (LD) etc. can generate the device of the light wave of different wave length.In this example, light source assembly 11 includes luminous component 111 and shines Component 112, luminous component 111 and luminous component 112 are integrated into an entirety, and can emit different central wavelengths or different frequencies The light wave of spectrum, for example, luminous component 111 can emission center wavelength be 620nm light wave, the light wave that luminous component 112 emits Central wavelength can near the isobestic point of oxyhemoglobin and deoxyhemoglobin, such as luminous component 112 emit light The central wavelength of wave is 850nm.
In one possible implementation, processing component 13 is also used to control at least two illumination regions of light source assembly 11 Part shines in light period according to predetermined order.In this example, the luminous week of luminous component 111 and luminous component 112 in 1ms The light wave that central wavelength is 620nm and the light wave that central wavelength is 850nm are successively issued in phase.Light period can also be shorter, more Short light period make two luminous components closer to and meanwhile shine, photoelectric detection component is also closer to being detected simultaneously by Reflected light signal.
In embodiment of the disclosure, the response section of photoelectric detection component 12 covers at least two luminous components institute Emit the central wavelength of light wave or in the spectral range of the light emitted wave of at least two luminous components.In this example, light It is the Si-based photodetectors of 400nm-1100nm that response wave length, which can be used, in all detection parts of electro-detection component 12.It is described Light wave is received after the reflection of detected object by the photoelectric detection component 12 being arranged in around light source assembly 11.
In one possible implementation, photoelectric detection component 12 includes multiple detection parts, the multiple test section Part arranges that the distance between each Photoelectric Detection component and light source assembly 11 are first distance, described around light source assembly 11 First distance is the distance determined by Monte-carlo Simulation Method, and the distance between light source assembly 11 and detection part are described When first distance, the ratio of the light intensity for the light wave that light intensity and the light source assembly 11 of the optical signal through detected object reflection issue is big In first threshold, that is, in the case where the light intensity for the light wave that light source assembly 11 issues is certain, optical signal that detection part receives Light intensity can satisfy detection needs.
In one possible implementation, Monte-carlo Simulation Method is having of transmitting in biological tissues of simulated photons One of mathematical method is imitated, is the statistical calculation method that simulated photons are walked in biological tissue's internal random.Effectively to react raw Multi-layer biological tissue model can be used come the case where simulating optical transport in the genuine property of object tissue.The incident biological group of beam orthogonal Surface is knitted, mirror-reflection and transmission occurs in air and tissue upper and lower surface, for example, occurring at i-th layer with i+1 bed boundary Transmission and mirror-reflection, and photon can be absorbed and scatter inside biological tissue.In this example, photon can be set at biological group The step-length of internal random walking is knitted, and analog goes out the general path of photon random walk, receives reflected light so as to obtain The strongest position of the light intensity of wave.When in this example, between the distance between light source assembly 11 8mm-1cm, the light of reflecting light It is most strong by force.
In this example, the first distance can be 1cm, which made instead by the way that Monte-carlo Simulation Method is determining The ratio between the light intensity of light wave that the light intensity and light source assembly 11 for penetrating optical signal issue reaches the light intensity of maximum value.The disclosure to first away from From specific value with no restriction.
In one possible implementation, multiple detection parts can be respectively positioned on the position of the light source assembly 11 as circle The heart, using the first distance as on the circle of radius.In this example, photoelectric detection component 12 includes 4 detection part (detection parts 121, detection part 122, detection part 123 and detection part 124), 4 detection parts are respectively positioned on the position of light source assembly 11 For the center of circle, using 1cm as on the circle of radius, also, 4 detection parts form 4 vertex of rectangle, and light source assembly 11 is located at described On the diagonal line of rectangle.It should be appreciated that those skilled in the art can set according to actual needs detection part quantity and its Be arranged position, the disclosure to this with no restriction.
In embodiment of the disclosure, processing component 13 can carry out letter to multiple first detection signals of multiple detection parts Number processing, and is stored and transmitted.
Fig. 3 is the stream that processing component 13 shown according to an exemplary embodiment carries out signal processing to first detection signal Cheng Tu.In embodiment of the disclosure, detection data can be the blood oxygen saturation of detected object, and processing component 13 is to described First detection signal carries out signal processing, obtains detection data and includes:
In step S31, analog-to-digital conversion is carried out to multiple first detection signals of the multiple detection part, and asked And processing, obtain digital detection signal;
In step s 32, calculus of differences is carried out to the digital detection signal, obtains the blood oxygen saturation of each light period Degree;
In step S33, according to the blood oxygen saturation of each light period, the blood oxygen saturation in first time period is determined Degree.
In one possible implementation, in step S31, first detection signal can be voltage signal, to described Voltage signal can directly acquire digital detection signal after carrying out analog-to-digital conversion.First detection signal can also be current signal, can After the current signal is converted into voltage signal, then analog-to-digital conversion is carried out, to obtain digital detection signal.In addition, can also be right After the voltage signal is filtered, then carry out analog-to-digital conversion.
In one possible implementation, light source assembly 11 may include two luminous components, described two luminous components The light wave of different central wavelengths or different spectral is successively issued in light period, photoelectric detection component 12 may include multiple detections Component, the multiple detection part successively detect the reflecting light of different central wavelengths or different spectral in light period, Processing component 13 carries out summation process after the first detection signal that multiple detection parts detect being carried out analog-to-digital conversion again, with Obtain the digital detection signal of the light wave of different central wavelengths or different spectral in light period.
For example, the emission center wavelength first of luminous component 111 is λ in light period1Light wave, it is after reflection, multiple Detection part detects reflecting light, and is respectively formed first detection signal, processing component 13 to all first detection signals into After row analog-to-digital conversion, then summation process is carried out, is λ with acquisition and central wavelength1The corresponding digital detection signal of light wave.Together Reason, in light period, after luminous component 111 shines, it is λ that luminous component 112, which issues central wavelength,2Light wave, place Managing component 13 and obtaining according to above-mentioned processing method with central wavelength is λ2The corresponding digital detection signal of light wave.
In one possible implementation, step S32 may include:
In step S321, according to the corresponding number of light wave of light period pair and the different central wavelengths or different spectral Word detection signal carries out calculus of differences respectively, to obtain the relationship between the amplitude of digital detection signal and hemoglobin concentration;
In step S322, according to the relationship between the amplitude and hemoglobin concentration of the digital detection signal, obtain The blood oxygen saturation of each light period.
In one possible implementation, in step S321, calculus of differences can be carried out to digital detection signal.Showing In example, k-th of light period tkDigital detection signal amplitude be R (tk) ,+1 light period t of kthk+1Digital detection signal Amplitude is R (tk+1), after taking natural logrithm to two above digital detection signal amplitude, difference fortune is carried out according to following equation (1) It calculates:
Wherein, A (tk+1)=ln R (tk+1), A (tk)=lnR (tk), tkAt the time of beginning for k-th of light period, tk+1 At the time of beginning for+1 light period of kth, μaFor absorption coefficient, i.e. photon absorbed probability in unit path, c is light Speed.
In one possible implementation, when measuring blood oxygen saturation, it can only consider oxyhemoglobin (HbO2) And the content of deoxyhemoglobin (Hb), hemoglobin concentration may include oxyhemoglobin concentrationWith the blood red egg of deoxidation White concentration CHb.Therefore equation (1) can write following equation (2):
Wherein, Δ Ak=A (tk+1)-A(tk), Δ tk=tk+1-tk, For the suction of oxyhemoglobin Backscatter extinction logarithmic ratio, εHbFor the absorptivity of deoxyhemoglobin.
In one possible implementation, from the equations above (2), according to light period pair from it is described it is different in cardiac wave Long or different spectral the corresponding digital detection signal of light wave carries out calculus of differences respectively, can obtain central wavelength or different spectral The corresponding digital detection signal of light wave amplitude and hemoglobin concentration between relationship.
In one possible implementation, above equation (2) are based on, a length of λ of centering cardiac wave1The corresponding number of light wave It detects signal and carries out calculus of differences, can get central wavelength is λ1The corresponding digital detection signal of light wave and hemoglobin concentration Between relational expression (3):
In one possible implementation, above equation (2) are based on, a length of λ of centering cardiac wave2The corresponding number of light wave It detects signal and carries out calculus of differences, can get central wavelength is λ2The corresponding digital detection signal of light wave and hemoglobin concentration Between relational expression (4):
In one possible implementation, blood oxygen saturation can be indicated by following equation (5):
Wherein, SpO2For blood oxygen saturation.
Therefore, in step S322, the blood oxygen saturation of k-th of light period can be obtained according to equation (3) and equation (4) Spend SpO2(k), SpO2(k) it can be indicated according to following equation (6):
Wherein,
In one possible implementation, work as central wavelength lambda2For oxyhemoglobin and deoxyhemoglobin etc. Absorb point when, equation (6) can approximate representation be following equation (7):
It, can be in the number to kth+1 light period and k-th of light period according to calculus of differences described in step S32 When detecting signal and carrying out calculus of differences, the Uniform noise in the signal of place to go, thus by the detection data of effectively physiologic information from It is extracted in noise, and eliminates the interference of the relative motion noise between photoelectric detection component 11 and detected object.
It in one possible implementation, can be by the blood of all light periods in first time period in step S33 The arithmetic average of oxygen saturation is determined as the blood oxygen saturation of the detected object.Calculate all hairs in first time period The arithmetic average of the blood oxygen saturation of photoperiod can exclude the influence of the possible misalignment of single measurement, improve in first time period The measurement accuracy of blood oxygen saturation.In this example, first time period includes N number of light period, that is, the value range of k be 1, 2 ..., N can determine N number of SpO according to following equation (8)2(k) arithmetic average, it is full as the blood oxygen in first time period And degree
In one possible implementation, first time period can be cardiac cycle.In this example, detected object Heart rate is 60 beats/min, i.e., each second, heartbeat was primary, then cardiac cycle is 1 second.Light period can be 1ms, then and first Period may include 1000 light periods, i.e. N=1000.In this example, the blood oxygen saturation in first time periodIt can To be SpO2(1)、SpO2(2)、…、SpO2(1000) arithmetic average.
In one possible implementation, first time period may include multiple cardiac cycles.It is determining at the first time Blood oxygen saturation in sectionWhen, the blood oxygen saturation of each cardiac cycle can be calculated, then calculate the blood of each cardiac cycle It is flat can also directly to calculate counting for the blood oxygen saturation of all light periods in first time period for the arithmetic average of oxygen saturation Mean value.
In this example, it can be the cardiac cycle of detected object 1 second, light period can be 1ms, and first time period can Included for 3 cardiac cycle.The blood oxygen saturation of cardiac cycle can be the blood oxygen of 1000 light periods in the cardiac cycle The arithmetic average of saturation degree, the blood oxygen saturation in first time period can be the calculation of the blood oxygen saturation of 3 cardiac cycle Number average value.Blood oxygen saturation in first time period can also be that the blood oxygen of 3000 light periods in first time period is full With the arithmetic average of degree.Both the above calculates the arithmetic average of the blood oxygen saturation of the light period in first time period Method is equivalent.The disclosure to calculate arithmetic average method with no restrictions.
In one possible implementation, processing component 13 can be that single-chip microcontroller, CPU, MPU, FPGA etc. are any can be into The processing apparatus of row signal processing, processing component 13 can be realized by special hardware circuit, can also pass through general procedure portion Part combines executable logical order to realize, to execute the treatment process of processing component 13.
In accordance with an embodiment of the present disclosure, the flexible physiological information monitoring device further includes power supply module, and power supply module can Electric power is provided for processing component 13, light source assembly 11, if photoelectric detection component 12 needs to power, power supply module can also be photoelectricity Detection components 12 provide electric power.
In one possible implementation, flexible physiological information monitoring device may also include R-T unit, transmitting-receiving dress It sets to establish using the modes such as bluetooth, infrared, Wireless Fidelity (WIFI) and terminal (such as smart phone etc.) and communicate to connect, from And realize the communication between device for detecting luminous flux and terminal.
R-T unit can will test data and be sent to terminal, so that terminal is recorded, handled and analyzed.Meanwhile it receiving and dispatching Device also can receive the instruction of terminal, and processing component 13 is made to execute described instruction.
In embodiment of the disclosure, the flexible physiological information monitoring device may also include storage assembly, can be used for depositing Detection data is stored up, and the storage record of the detection data of batch export when needed.In addition, power supply module, transmitting-receiving subassembly and storage Component can be connect by flexible wire with processing component 13, may alternatively be integrated in processing component 13.
In accordance with an embodiment of the present disclosure, for carrying the lining of light source assembly 11, photoelectric detection component 12 and processing component 13 Bottom 14 is fabricated from a flexible material, and can be attached on skin, can also be integrated in wearable device, in this example, described flexible raw Reason information monitoring device is used as flexible oxygen saturation monitor device, and flexible oxygen saturation monitor device can be attached on skin, can also collect At in wearable device, blood oxygen saturation can be determined according to detection data, and smaller to the interference of measurand, when can be long Between use.
Fig. 4 is the schematic diagram of the flexible oxygen saturation monitor device shown according to an exemplary embodiment being integrated in the helmet. In embodiment of the disclosure, flexible oxygen saturation monitor device is integrated in the helmet, which can be the helmet of pilot, The blood oxygen saturation of pilot is monitored during pilot driver aircraft.
In this example, flexible oxygen saturation monitor device is fixed in the speciality liner for being fixed on the helmet, pilot's forehead Size and shape difference, to reduce the loss in light wave transmissions, substrate can be made of the bio-compatible material for having elasticity, To be bonded the forehead of pilot.The window that suitable size is opened and closed at the light transmission needed for light source assembly and photoelectric detection component, so that light The light wave that source component issues is incident to pilot's forehead position with lower loss, the light letter after the reflection of the forehead of pilot It number is received by photoelectric monitor component, to obtain detection signal.Processing component carries out signal to the detection signal of photoelectric detection component Processing obtains detection data, to determine the blood oxygen saturation of pilot according to detection data.
Processing component can will due to external environmental interference (for example, the noise jamming that pilot generates during exercise, detection Device and human skin generate relative displacement and the noise jamming that generates) and the periodical volume wave signal extraction flooded comes out, Therefore, the flexible oxygen saturation monitor device can effectively remove noise jamming, improve blood oxygen saturation in the state of work Detection accuracy.In addition, flexible oxygen saturation monitor device may include R-T unit, pass through R-T unit, the blood oxygen saturation of pilot Information can be sent to master station, provide reference for evaluation pilot's physiological parameter.Flexible oxygen saturation monitor device can also directly by Detection data is sent to master station, and master station can determine the blood oxygen saturation of pilot according to detection data.
It, can be by flexible physiological information monitoring device effective integration to aircrew helmet by using embodiment of the disclosure In, blood oxygenation information of the pilot in flight course is monitored, and filter out noise jamming in real time, obtains accurate blood oxygen Saturation infromation.Transmitting-receiving subassembly and master station are wirelessly connected, and guarantee that master station grasps the physiologic information of pilot in real time, to be The physical signs of pilot makes corresponding evaluation.The physiological information detection device interferes very little to pilot, can be in pilot It is in-flight carried out continuously pulse wave blood oxygen saturation monitoring for a long time, master station is enabled to obtain the physiology letter of pilot in real time Breath.
The presently disclosed embodiments is described above, above description is exemplary, and non-exclusive, and It is not limited to disclosed each embodiment.Without departing from the scope and spirit of illustrated each embodiment, for this skill Many modifications and changes are obvious for the those of ordinary skill in art field.The selection of term used herein, purport In the principle, practical application or technological improvement to the technology in market for best explaining each embodiment, or lead this technology Other general master stations in domain, which lead to technical staff, can understand each embodiment disclosed herein.

Claims (10)

1. a kind of flexible physiological information monitoring device, which is characterized in that including:Light source assembly, photoelectric detection component, processing component And substrate;
The light source assembly is used to emit light wave to detected object;
The photoelectric detection component is used to carry out photoelectric conversion to optical signal of the light wave after detected object reflection, Obtain first detection signal;
The processing component is used to carry out signal processing to the first detection signal, obtains detection data;
The substrate is fabricated from a flexible material, for carrying the light source assembly, the photoelectric detection component and the processing group Part;
Wherein, the photoelectric detection component includes multiple detection parts around light source assembly arrangement, the multiple detection The distance between component and the photoelectric detection component are first distance, and the first distance is the light intensity so that the optical signal It is greater than or equal at a distance from first threshold with the ratio of the light intensity of the light wave.
2. the apparatus according to claim 1, which is characterized in that the light source assembly includes at least two luminous components, institute The light wave that at least two luminous components emit different central wavelengths or different spectral respectively is stated,
Wherein, the processing component be also used to control at least two luminous components of the light source assembly in light period according to Predetermined order shines,
Wherein, the response section of the photoelectric detection component covers the middle cardiac wave of the light emitted wave of at least two luminous components It grows or in the spectral range of the light emitted wave of at least two luminous components.
3. the apparatus of claim 2, which is characterized in that the detection data includes the blood oxygen saturation of detected object Degree, the processing component carry out signal processing to the first detection signal, obtain detection data and include:
Analog-to-digital conversion is carried out to multiple first detection signals of the multiple detection part, and carries out summation process, obtains number Detect signal;
Calculus of differences is carried out to the digital detection signal, obtains the blood oxygen saturation of each light period;
According to the blood oxygen saturation of each light period, the blood oxygen saturation in first time period is determined.
4. device according to claim 3, which is characterized in that carry out calculus of differences to the digital detection signal, obtain The blood oxygen saturation of each light period includes:
According to light period pair and the corresponding digital detection signal of light wave of the different central wavelengths or different spectral respectively into Row calculus of differences, to obtain the relationship between the amplitude of digital detection signal and hemoglobin concentration;
According to the relationship between the amplitude and hemoglobin concentration of the digital detection signal, the blood oxygen of each light period is obtained Saturation degree.
5. device according to claim 3, which is characterized in that according to the blood oxygen saturation of each light period, determine Blood oxygen saturation in one period includes:
The arithmetic average of the blood oxygen saturation of all light periods in first time period is determined as the detected object Blood oxygen saturation.
6. the apparatus according to claim 1, which is characterized in that the first distance is true by Monte-carlo Simulation Method Fixed.
7. the apparatus according to claim 1, which is characterized in that the photoelectric detection component includes multiple detection parts, institute It states multiple detection parts to be respectively positioned on using the position of the light source assembly as the center of circle, using the first distance as on the circle of radius.
8. the apparatus according to claim 1, which is characterized in that further include:Encapsulated layer is fabricated from a flexible material, for sealing The light source assembly, the photoelectric detection component and the processing component are filled, and is engaged with the flexible substrate.
9. the apparatus according to claim 1, which is characterized in that further include:Transmitting-receiving subassembly, for sending out the detection data It send to terminal, and receives the instruction of the terminal.
10. device described in any one of -9 according to claim 1, which is characterized in that described device includes flexible blood oxygen prison Device is surveyed, the flexibility oxygen saturation monitor device is integrated in wearable device, full with the blood oxygen of the determination detected object And degree.
CN201810541996.5A 2018-05-30 2018-05-30 Flexible physiological information monitoring device Pending CN108814620A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110811639A (en) * 2019-11-06 2020-02-21 浙江清华柔性电子技术研究院 Total bilirubin detection patch and total bilirubin detection system
CN110974249A (en) * 2019-12-13 2020-04-10 华中科技大学 Epidermis attaching type blood oxygen saturation detection system and preparation thereof
WO2020078287A1 (en) * 2018-10-19 2020-04-23 杰能科技顾问有限公司 Solar detection module and solar panel
CN112842365A (en) * 2021-02-25 2021-05-28 清华大学 Detection device and manufacturing method thereof
CN114468989A (en) * 2021-02-11 2022-05-13 先阳科技有限公司 Tissue component measuring method and device and wearable equipment
CN114468993A (en) * 2021-02-11 2022-05-13 先阳科技有限公司 Tissue component measuring method and device and wearable equipment
CN114468990A (en) * 2021-02-11 2022-05-13 先阳科技有限公司 Method and device for detecting components of living tissue and wearable equipment

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201481424U (en) * 2009-09-03 2010-05-26 深圳市索莱瑞医疗技术有限公司 Forehead type blood oxygen saturation probe
WO2013166463A1 (en) * 2012-05-03 2013-11-07 Vioptix, Inc. Monte carlo and iterative methods for determination of tissue oxygen saturation
CN103610467A (en) * 2013-11-05 2014-03-05 李鲁亚 Parallel near-infrared photoelectric sensing device and system and method for detecting organs and tissue of animals
CN104173059A (en) * 2014-09-04 2014-12-03 电子科技大学 Optical non-intrusive shock monitor and detection method thereof
US8956289B2 (en) * 2005-10-14 2015-02-17 Konica Minolta Sensing, Inc. Vital information measuring device
WO2016035881A1 (en) * 2014-09-05 2016-03-10 パナソニックヘルスケアホールディングス株式会社 Method for quantifying glucose concentration and glucose concentration measurement device
CN105510238A (en) * 2014-09-28 2016-04-20 天津先阳科技发展有限公司 Multi-position diffusion spectral data processing, modeling, and predicting method and processing device
CN106137219A (en) * 2016-08-04 2016-11-23 天津大学 The absolute difference of dual wavelength adds and calculates arterial oxygen saturation method and device thereof
CN106798549A (en) * 2017-02-27 2017-06-06 清华大学 A kind of blood oxygen transducer based on flexible extending substrate
CN206414278U (en) * 2016-08-23 2017-08-18 公安部第一研究所 A kind of blood oxygen detection means
WO2018066519A1 (en) * 2016-10-03 2018-04-12 国立大学法人大阪大学 Electrode sheet

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8956289B2 (en) * 2005-10-14 2015-02-17 Konica Minolta Sensing, Inc. Vital information measuring device
CN201481424U (en) * 2009-09-03 2010-05-26 深圳市索莱瑞医疗技术有限公司 Forehead type blood oxygen saturation probe
WO2013166463A1 (en) * 2012-05-03 2013-11-07 Vioptix, Inc. Monte carlo and iterative methods for determination of tissue oxygen saturation
CN104411241A (en) * 2012-05-03 2015-03-11 维奥普蒂克斯公司 Tissue oximetry probe geometry for robust calibration and self-correction
CN103610467A (en) * 2013-11-05 2014-03-05 李鲁亚 Parallel near-infrared photoelectric sensing device and system and method for detecting organs and tissue of animals
CN104173059A (en) * 2014-09-04 2014-12-03 电子科技大学 Optical non-intrusive shock monitor and detection method thereof
WO2016035881A1 (en) * 2014-09-05 2016-03-10 パナソニックヘルスケアホールディングス株式会社 Method for quantifying glucose concentration and glucose concentration measurement device
CN105510238A (en) * 2014-09-28 2016-04-20 天津先阳科技发展有限公司 Multi-position diffusion spectral data processing, modeling, and predicting method and processing device
CN106137219A (en) * 2016-08-04 2016-11-23 天津大学 The absolute difference of dual wavelength adds and calculates arterial oxygen saturation method and device thereof
CN206414278U (en) * 2016-08-23 2017-08-18 公安部第一研究所 A kind of blood oxygen detection means
WO2018066519A1 (en) * 2016-10-03 2018-04-12 国立大学法人大阪大学 Electrode sheet
CN106798549A (en) * 2017-02-27 2017-06-06 清华大学 A kind of blood oxygen transducer based on flexible extending substrate

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
LI, HAICHENG等: "Epidermal inorganic optoelectronics for blood oxygen measurement", 《ADVANCED HEALTHCARE MATERIALS》 *
MICHAEL S. PATTERSON: "Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties", 《APPLIED OPTICS》 *
孙喜庆,等: "《重力生理学理论与实践》", 31 January 2009 *
李婷: "《生物医学光子传输》", 30 April 2015, 武汉大学出版社 *
王伟,等: "基于差分因子的血氧饱和度算法研究", 《科技视界》 *
王荣芳: "反射式血氧饱和度检测***的研制", 《中国优秀硕士学位论文全文数据库 信息科技辑》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020078287A1 (en) * 2018-10-19 2020-04-23 杰能科技顾问有限公司 Solar detection module and solar panel
CN110811639A (en) * 2019-11-06 2020-02-21 浙江清华柔性电子技术研究院 Total bilirubin detection patch and total bilirubin detection system
CN110811639B (en) * 2019-11-06 2023-11-21 浙江清华柔性电子技术研究院 Total bilirubin detection patch and total bilirubin detection system
CN110974249A (en) * 2019-12-13 2020-04-10 华中科技大学 Epidermis attaching type blood oxygen saturation detection system and preparation thereof
CN114468989A (en) * 2021-02-11 2022-05-13 先阳科技有限公司 Tissue component measuring method and device and wearable equipment
CN114468993A (en) * 2021-02-11 2022-05-13 先阳科技有限公司 Tissue component measuring method and device and wearable equipment
CN114468990A (en) * 2021-02-11 2022-05-13 先阳科技有限公司 Method and device for detecting components of living tissue and wearable equipment
CN114468993B (en) * 2021-02-11 2023-03-10 先阳科技有限公司 Tissue component measuring method and device and wearable equipment
CN112842365A (en) * 2021-02-25 2021-05-28 清华大学 Detection device and manufacturing method thereof

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