CN108813084A - A kind of chewable composition and preparation method thereof containing phosphosilicate glass - Google Patents
A kind of chewable composition and preparation method thereof containing phosphosilicate glass Download PDFInfo
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- CN108813084A CN108813084A CN201810531130.6A CN201810531130A CN108813084A CN 108813084 A CN108813084 A CN 108813084A CN 201810531130 A CN201810531130 A CN 201810531130A CN 108813084 A CN108813084 A CN 108813084A
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- CN
- China
- Prior art keywords
- matrix
- chewable
- glass
- phosphosilicate glass
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005360 phosphosilicate glass Substances 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 32
- 229940112822 chewing gum Drugs 0.000 claims abstract description 32
- 239000011159 matrix material Substances 0.000 claims description 44
- 239000011521 glass Substances 0.000 claims description 37
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 24
- 239000011574 phosphorus Substances 0.000 claims description 24
- 229910052698 phosphorus Inorganic materials 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 239000005368 silicate glass Substances 0.000 claims description 21
- 239000004014 plasticizer Substances 0.000 claims description 19
- 239000003963 antioxidant agent Substances 0.000 claims description 16
- 235000003599 food sweetener Nutrition 0.000 claims description 16
- 239000003205 fragrance Substances 0.000 claims description 16
- 239000003765 sweetening agent Substances 0.000 claims description 16
- 230000003078 antioxidant effect Effects 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 15
- 239000000945 filler Substances 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 229910052681 coesite Inorganic materials 0.000 claims description 11
- 229910052906 cristobalite Inorganic materials 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- 229910052682 stishovite Inorganic materials 0.000 claims description 11
- 229910052905 tridymite Inorganic materials 0.000 claims description 11
- 150000004706 metal oxides Chemical class 0.000 claims description 10
- 230000032683 aging Effects 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- 238000002844 melting Methods 0.000 claims description 9
- 230000008018 melting Effects 0.000 claims description 9
- 229910044991 metal oxide Inorganic materials 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 239000000391 magnesium silicate Substances 0.000 claims description 8
- 229910052919 magnesium silicate Inorganic materials 0.000 claims description 8
- 235000019792 magnesium silicate Nutrition 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- LWNCNSOPVUCKJL-UHFFFAOYSA-N [Mg].[P] Chemical compound [Mg].[P] LWNCNSOPVUCKJL-UHFFFAOYSA-N 0.000 claims description 7
- 238000001125 extrusion Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229920001206 natural gum Polymers 0.000 claims description 6
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 6
- 239000011118 polyvinyl acetate Substances 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000000052 vinegar Substances 0.000 claims description 6
- 235000021419 vinegar Nutrition 0.000 claims description 6
- 241000512005 Alstonia Species 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 5
- 244000269722 Thea sinensis Species 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- 239000011701 zinc Substances 0.000 claims description 5
- 108010011485 Aspartame Proteins 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 235000005979 Citrus limon Nutrition 0.000 claims description 4
- 244000131522 Citrus pyriformis Species 0.000 claims description 4
- 240000000560 Citrus x paradisi Species 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 244000246386 Mentha pulegium Species 0.000 claims description 4
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 4
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- ZFQMZNFNJHUGKL-UHFFFAOYSA-N [Sr].[Si](O)(O)(O)O.[P] Chemical compound [Sr].[Si](O)(O)(O)O.[P] ZFQMZNFNJHUGKL-UHFFFAOYSA-N 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 235000021552 granulated sugar Nutrition 0.000 claims description 4
- 235000001050 hortel pimenta Nutrition 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 239000004200 microcrystalline wax Substances 0.000 claims description 4
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 4
- 229910052755 nonmetal Inorganic materials 0.000 claims description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 4
- 235000013824 polyphenols Nutrition 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 229910052712 strontium Inorganic materials 0.000 claims description 4
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- 229920002367 Polyisobutene Polymers 0.000 claims description 3
- JOXCDOKKASTCHR-UHFFFAOYSA-N [Si](O)(O)(O)O.[P] Chemical compound [Si](O)(O)(O)O.[P] JOXCDOKKASTCHR-UHFFFAOYSA-N 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 101000801619 Homo sapiens Long-chain-fatty-acid-CoA ligase ACSBG1 Proteins 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 102100033564 Long-chain-fatty-acid-CoA ligase ACSBG1 Human genes 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- CZMRCDWAGMRECN-UHFFFAOYSA-N Rohrzucker Natural products OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O CZMRCDWAGMRECN-UHFFFAOYSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 235000021028 berry Nutrition 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 235000010634 bubble gum Nutrition 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 235000015320 potassium carbonate Nutrition 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000001993 wax Substances 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 244000141359 Malus pumila Species 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 9
- 210000003296 saliva Anatomy 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 5
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 208000020670 canker sore Diseases 0.000 abstract description 2
- 208000007565 gingivitis Diseases 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 235000006708 antioxidants Nutrition 0.000 description 8
- 239000000120 Artificial Saliva Substances 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 239000004110 Zinc silicate Substances 0.000 description 5
- JMTIXSZQYHAMLY-UHFFFAOYSA-N [P].[Zn] Chemical compound [P].[Zn] JMTIXSZQYHAMLY-UHFFFAOYSA-N 0.000 description 5
- 238000003483 aging Methods 0.000 description 5
- 235000019628 coolness Nutrition 0.000 description 5
- 210000004268 dentin Anatomy 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 5
- 235000019352 zinc silicate Nutrition 0.000 description 5
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
- PXAOSGRNSNAHEO-UHFFFAOYSA-N [P].[Sr] Chemical compound [P].[Sr] PXAOSGRNSNAHEO-UHFFFAOYSA-N 0.000 description 2
- 230000033558 biomineral tissue development Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- -1 phosphate anion Chemical class 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229910001414 potassium ion Inorganic materials 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 229910052917 strontium silicate Inorganic materials 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 244000089742 Citrus aurantifolia Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- HIVGXUNKSAJJDN-UHFFFAOYSA-N [Si].[P] Chemical compound [Si].[P] HIVGXUNKSAJJDN-UHFFFAOYSA-N 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000009740 moulding (composite fabrication) Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- OYLRFHLPEAGKJU-UHFFFAOYSA-N phosphane silicic acid Chemical compound P.[Si](O)(O)(O)O OYLRFHLPEAGKJU-UHFFFAOYSA-N 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000005361 soda-lime glass Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Confectionery (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to oral health technical fields, and in particular to a kind of chewable composition (such as chewing gum) and preparation method thereof containing phosphosilicate glass.The present invention is prepared for a kind of chewable composition and chewable object containing phosphosilicate glass, and after contacting with saliva of buccal cavity a series of chemical reaction can occur for phosphosilicate glass therein, finally plays it in tooth or the repairing effect of gingival surface.And, the phosphosilicate glass in composition and chewable object can be chewed due to high stripping property, stablizing pH value in the present invention, several genes can be promoted to express, it can achieve and prevent and treat the oral problems such as mouth infection, canker sore and gingivitis, simultaneously by its remineralization on tooth, hemodia can be alleviated.Preparation method simple process of the invention, raw material is cheap and easy to get, is suitble to industrialized large-scale production.
Description
Technical field
The invention belongs to oral health technical fields, and in particular to a kind of chewable combination containing phosphosilicate glass
Object, chewable object (such as chewing gum) containing the composition and preparation method thereof.
Background technique
Chewing gum is a kind of sugar that chewing in mouth is put into for people, deep to be liked by children and young people, and the elderly chews mouth
Fragrant sugar is also not within minority.It can remove the swill of dental surface by chew gum, masticatory movement promotes facial blood
The exercise of liquid circulation and muscle, mechanical stimulus can increase the secretion of saliva again, rinse oral surfaces, there is certain cleaning oral cavity
Effect.Active constituent with certain function is introduced into chewing gum, can in such a way that a kind of people like to tooth into
Row functional protection.
Patent document TW201039860A1 discloses a kind of non-aqueous toothpaste constituent containing bioactivity glass, uses
In alleviation sensitivity of tooth.But bioactivity glass degradation therein is slowly, and people use the time of toothpaste shorter every time,
It will affect the formation speed of mineralized layer.In addition, chewing gum presence currently on the market has a single function, preparation method is complicated, raw material
The problems such as price is high.
Therefore, it studies a kind of with other function, the chewing gum that preparation method is simple, raw material is cheap and easy to get, has important
Meaning.
Summary of the invention
The purpose of the present invention is to provide a kind of chewable composition containing phosphosilicate glass and contain the composition
Chewable object (such as chewing gum).Applicants have found that phosphosilicate glass is constantly steady when having high stripping property and using
Determine pH, can discharge rapidly phosphate anion and calcium, strontium, magnesium, zinc, potassium or sodium ion in the environment such as saliva, while
Material surface forms rich SiO2Layer of silica gel, then Ca2+And PO4 3-In SiO2Layer of silica gel on form CaO-P2O5Unformed layer,
Recrystallization is changed into hydroxyapatite (HA), and the mineralising behavior of substrate (such as tooth) on the one hand can be improved, on the other hand can
Promote several genes expression, makes it that can be bonded with sclerous tissues and be bonded between soft tissue, if being introduced into
In chewable composition, it should repairing effect can be played in tooth or gingival surface；Based on the discovery that proposing this hair
It is bright.
The invention proposes a kind of chewable composition containing phosphosilicate glass includes matrix and phosphosilicate glass
At least one of glass, and optionally following components：Sweetener, fragrance, interfacial agent, plasticizer, filler material and anti-oxidant
Agent.
According to the present invention, the weight percent of each component can be in the chewable composition：Matrix 15-93%, phosphorus
Silicate glass 1-52%, sweetener 0-25%, fragrance 0-30%, interfacial agent 0-8%, plasticizer 0-8%, filler material 0-
25%, antioxidant 0-0.1%, the sum of each component content are 100%.
Preferably, the weight percent of each component can be in the chewable composition：Matrix 20-88%, phosphorus silicic acid
Salt glass 3-50%, sweetener 0-20%, fragrance 0-25%, interfacial agent 0-3%, plasticizer 0-3%, filler material 0-
20%, antioxidant 0-0.02%, the sum of each component content are 100%.
According to the present invention, the phosphosilicate glass be as known to those skilled in the art it is any be suitable for body of the present invention
The phosphosilicate glass of system, the phosphosilicate glass include metal oxide and nonmetal oxide, wherein described non-
Metal oxide is SiO2And P2O5, the metal oxide is one of oxides such as calcium, strontium, magnesium, zinc, sodium, potassium or several
Kind.
Further, the weight percent of each component can be in phosphosilicate glass：SiO240-60%, P2O515-
30%, metal oxide 20-40%, the sum of each component content are 100%.
Preferably, the group of phosphosilicate glass becomes：SiO245-55%, P2O520-25%, metal oxide 25-
35%, the sum of each component content is 100%.
According to the present invention, the phosphosilicate glass is selected from phosphorus calcic silicate glass, phosphorus silicic acid strontium glass, phosphorus magnesium silicate glass
One of glass, phosphorus zinc silicate glass, phosphorus water pearl ash glass, phosphorus water soda glass are a variety of (two or more).
According to the present invention, the preparation method of the phosphosilicate glass includes but is not limited to sol-gal process.
According to the present invention, the matrix is selected from tunny gum, processing common alstonia gel matrix, polyvinyl acetate, poly- isobutyl
One of alkene, vinegar natural gum etc. are a variety of (two or more).
According to the present invention, the sweetener is selected from granulated sugar, glucose, starch sugar, beet sugar, sucrose, maltose, sorbose
One of alcohol, mannitol, xylitol, Aspartame etc. are a variety of (two or more).
According to the present invention, the fragrance is selected from one of peppermint, orange, lemon, grapefruit, apple, berry etc. or a variety of
(two or more).
According to the present invention, the interfacial agent is selected from one of glycerol, vegetable oil, lecithin, two or three.
According to the present invention, the plasticizer is selected from one or both of microcrystalline wax, animals and plants wax.
The purpose that interfacial agent and/or plasticizer are added in the present invention be mainly improve Combination between each component with
And the processing performance of mixed system if Combination and processing performance are good enough does not need that interfacial agent and/or plastic is added
Agent is selected as the case may be.
According to the present invention, the filler material is selected from one of calcium carbonate, talcum, sodium sulphate, magnesium sulfate or (two kinds a variety of
Or two or more).
According to the present invention, the antioxidant is selected from tea polyphenols.
A kind of chewable object comprising above-mentioned chewable composition.Preferably, by above-mentioned chewable composition group
At.
According to the present invention, the chewable object is chewing gum, bubble gum etc..
The preparation method of the present invention also provides the above-mentioned chewable composition containing phosphosilicate glass, the preparation method
Include the following steps：
(1) matrix is heated, or by least one of matrix and optionally following components：Plasticizer and interfacial activity
Agent mixing, heating；The matrix melted；
(2) it is added in phosphosilicate glass and optionally following components in the matrix for the melting that step (1) obtains
It is at least one：Sweetener, fragrance, antioxidant and filler material, stirring, obtain the chewable composition.
According to the present invention, the matrix, phosphosilicate glass, sweetener, fragrance, interfacial agent, plasticizer, filling
Material, antioxidant have definition described above.
The present invention also provides the preparation methods of above-mentioned chewable object, and the preparation method comprises the following steps：
(1) matrix is heated, or by least one of matrix and optionally following components：Plasticizer and interfacial activity
Agent mixing, heating；The matrix melted；
(2) it is added in phosphosilicate glass and optionally following components in the matrix for the melting that step (1) obtains
It is at least one：Sweetener, fragrance, antioxidant and filler material, stirring, obtain the chewable composition；
(3) composition obtained step (2) carries out extrusion forming, cooling, cutting, aging, packaging, can obtain it is described can nozzle
Chew object.
According to the present invention, the matrix, phosphosilicate glass, sweetener, fragrance, interfacial agent, plasticizer, filling
Material, antioxidant have definition described above.
According to the present invention, in step (1), to make matrix preferably with other material mixings, obtain the good product of shape,
Plasticizer or interfacial agent can be added in the reaction.
According to the present invention, in step (2), for the freshness for keeping chewable object, antioxidant can be added in the reaction.
According to the present invention, in step (1), the temperature of the heating can be 105-165 DEG C, preferably 125-145 DEG C, example
Such as 125 DEG C, 135 DEG C, 145 DEG C；
According to the present invention, in step (3), the cooling temperature is 10-25 DEG C, preferably 15-20 DEG C, such as 15 DEG C, 17
℃、19℃、20℃。
The aging temperature is 25-30 DEG C, such as 25 DEG C, 30 DEG C；
According to the present invention, the relative humidity of the step (3) can be 45-60%, preferably 50-55%.
It is that after contacting with saliva of buccal cavity a system can occur for phosphosilicate glass therein that the characteristic of object can be chewed in the present invention
The chemical reaction of column therefrom discharges phosphate anion and calcium, strontium, magnesium, zinc, potassium or sodium ion first, while on the surface of the material
Form richness SiO2Layer of silica gel, then Ca2+And PO4 3-In SiO2Layer of silica gel on form CaO-P2O5Unformed layer, recrystallization turn
Become hydroxyapatite (HA), finally plays it in tooth or the repairing effect of gingival surface.Phosphosilicate glass in the present invention
Glass release ion is very fast, mainly due to wherein containing higher PO4 3-Plasma diffusing W,Mo promotes Ca2+And PO4 3-It can be quickly in material
Expect surface deposition, form mineralized layer faster, and the metal ion and PO of its release4 3-Neutralization can be played, material is made
There is stable pH value in body fluid.
Beneficial effect
The present invention is prepared for a kind of chewable composition and chewable object containing phosphosilicate glass, phosphorus silicic acid therein
After contacting with saliva of buccal cavity a series of chemical reaction can occur for salt glass, finally play it in the reparation of tooth or gingival surface
Effect.Moreover, phosphosilicate glass ion release rate is very fast in chewable composition and chewable object, it can be in oral environment
Lower promotion dental surface quickly forms chemical bonding, prevents dental decayed tooth and sensitivity of tooth.Also, the phosphosilicate in the present invention
The metal ion and PO of glass release4 3-Neutralization can be played, makes material that there is stable pH value in body fluid.
The phosphosilicate glass in composition and chewable object can be chewed due to high stripping property, stablizing pH in the present invention
Value, can promote several genes to express, and can achieve the oral cavities such as prevention and treatment mouth infection, canker sore and gingivitis and ask
Topic, while by its remineralization on tooth, hemodia can be alleviated.
Preparation method simple process of the invention, raw material is cheap and easy to get, is suitble to industrialized large-scale production.
Detailed description of the invention
Fig. 1：The SEM of phosphorus calcic silicate glass powder schemes；
Fig. 2：SEM figure for 24 hours is impregnated in artificial saliva：(a) traditional 45S5 glass；(b) phosphorus calcic silicate glass；
Fig. 3：Phosphorus calcic silicate glass chewing gum prepared by embodiment 1 deposits 1 day SEM figure in artificial saliva；
Fig. 4：Phosphorus magnesium silicate glass chewing gum prepared by embodiment 2 deposits 3 days XRD diagram in artificial saliva；
Fig. 5：The dentin surface SEM of different chewing gum stamping process schemes：(a) not phosphorous calcic silicate glass；(b) containing phosphorus silicon
Sour lime glass.
Specific embodiment
Further detailed description is done to the present invention below in conjunction with specific embodiment.It should be appreciated that the following example
It is merely illustrative the ground description and interpretation present invention, and is not necessarily to be construed as limiting the scope of the invention.It is all to be based on this hair
In the range of the technology that bright above content is realized is encompassed by the present invention is directed to protect.
Unless otherwise indicated, raw materials and reagents used in the following embodiment are commercial goods, or can be by
Perception method preparation.
The group of phosphosilicate glass becomes in following embodiment：SiO248% (wt%), metal oxide 29%
(wt%), P2O523% (wt%).
Embodiment 1
A kind of phosphorus calcic silicate glass chewing gum, wherein including tunny gum matrix 20g, phosphorus calcic silicate glass 50g, granulated sugar sweet tea
Taste agent 15g, Aspartame 5g, lemon 6g, grapefruit 2g and glycerol 2g.
The preparation method of phosphorus calcic silicate glass chewing gum is as follows：
(1) tunny gum, glycerol (interfacial agent) are heated to 145 DEG C, the matrix melted；
(2) it is gradually added phosphorus calcic silicate glass, granulated sugar, Aspartame, lemon and grapefruit in above-mentioned melting matrix, stirs
Uniformly, mixed raw material is obtained；
(3) mixed raw material is packed into extruder and carries out extrusion forming, 20 DEG C of coolings are cut, and 30 DEG C of agings are relatively wet
50-55% is spent, packaging can obtain.
Embodiment 2
A kind of phosphorus magnesium silicate glass chewing gum, wherein including polyvinyl acetate 40g, phosphorus magnesium silicate glass 30g, xylitol
20g and peppermint 10g.
The preparation method of phosphorus magnesium silicate glass chewing gum is as follows：
(1) polyvinyl acetate is heated to 135 DEG C, the matrix melted；
(2) it is gradually added phosphorus magnesium silicate glass, xylitol and peppermint in above-mentioned melting matrix, stirs evenly, is mixed
Close raw material；
(3) mixed raw material is packed into extruder and carries out extrusion forming, 15 DEG C of coolings are cut, and 25 DEG C of agings are relatively wet
50-55% is spent, packaging can obtain.
Embodiment 3
A kind of phosphorus zinc silicate glass chewing gum, wherein including polyvinyl acetate 60g, phosphorus zinc silicate glass 15g, orange
20g and apple 5g.
The preparation method of phosphorus zinc silicate glass chewing gum is as follows：
(1) polyvinyl acetate is heated to 135 DEG C, the matrix melted；
(2) it is gradually added phosphorus zinc silicate glass, orange and apple in above-mentioned melting matrix, stirs evenly, is mixed
Raw material；
(3) mixed raw material is packed into extruder and carries out extrusion forming, 15 DEG C of coolings are cut, and 25 DEG C of agings are relatively wet
50-55% is spent, packaging can obtain.
Embodiment 4
A kind of phosphorus strontium silicate glass chewing gum, wherein comprising polyisobutene 53g, vinegar natural gum 35g, phosphorus silicic acid strontium glass 8g,
Sucrose 1g and microcrystalline wax 3g.
The preparation method of phosphorus strontium silicate glass chewing gum is as follows：
(1) polyisobutene, vinegar natural gum and microcrystalline wax (plasticizer) are heated to 135 DEG C, the matrix melted；
(2) it is gradually added phosphorus silicic acid strontium glass and sucrose in above-mentioned melting matrix, stirs evenly, obtains mixed raw material；
(3) mixed raw material is packed into extruder and carries out extrusion forming, 15 DEG C of coolings are cut, and 25 DEG C of agings are relatively wet
50-55% is spent, packaging can obtain.
Embodiment 5
A kind of phosphorus water soda glass chewing gum, wherein comprising processing common alstonia gel matrix 39.8g, vinegar natural gum 35g, phosphorus silicic acid
Soda-lime glass 3g, calcium carbonate 20g, sucrose 2g and tea polyphenols 0.02g.
The preparation method of phosphorus water soda glass chewing gum is as follows：
(1) processing common alstonia gel matrix and vinegar natural gum are heated to 125 DEG C, the matrix melted；
(2) phosphorus water soda glass, calcium carbonate, sucrose and tea polyphenols are gradually added in above-mentioned melting matrix, stirred evenly,
Obtain mixed raw material；
(3) mixed raw material is packed into extruder and carries out extrusion forming, 15 DEG C of coolings are cut, and 25 DEG C of agings are relatively wet
50-55% is spent, packaging can obtain.
6 mineralization ability of experimental example detects (phosphosilicate glass)
The SEM of phosphorus calcic silicate glass powder schemes as shown in Figure 1, the phosphorus calcic silicate glass and tradition 45S5 glass phase ratio,
Phosphorus calcic silicate glass can form mineralized layer faster in artificial saliva, as shown in Figure 2.
7 mineralization ability of experimental example detects (phosphosilicate glass chewing gum)
By the phosphorus calcic silicate glass chewing gum in embodiment 1, it, which is put into artificial saliva, deposits 1 day, and discovery material surface has
The formation of mineralized layer, as shown in Figure 3.Similar, the phosphorus magnesium silicate glass chewing gum in embodiment 2 is put into artificial saliva and is sunk
Product 3 days, discovery material surface have the formation of mineralized layer, as shown in Figure 4.
8 effect detection of experimental example
Grinding one's teeth in sleep (6) of pulling out of hospital surgery outpatient service is chosen, is divided into 2 groups, it is every group 3, clean with normal saline flushing, it goes
Except root face dental calculus and parodontium, vertically remove corona enamel with spark saw, expose dentin surface, sand paper polishing preparation goes out
Unified dentin surface, after manually saliva is rinsed, by chewing gum (phosphorus calcic silicate glass chewing gum, implementation in embodiment 1
Remove the chewing gum of phosphorus calcic silicate glass component in example 1) surface of grinding one's teeth in sleep is lain in, hand holds the continuous punching press chewing gum of plastic rod,
The other hand, which is stablized, places grinding one's teeth in sleep on the table, suitably increases a small amount of artificial saliva, Mouthsimulator chewing environment in the process.
After punching press 15min, manually saliva is cleaned, and stands 2h, and manually saliva is cleaned after punching press 15min again, stands 2h, and SEM is seen
It examines after finding the chewing gum processing of not phosphorous calcic silicate glass, dentin surface only has minimal amount of mineralized layer to be formed, and passes through
After the chewing gum processing of phosphorous calcic silicate glass, dentin surface has the mineralized layer of large area to be formed, as shown in Figure 5.This explanation
Chewing gum containing phosphosilicate glass can preferably promote oral care and teeth caring repairing effect.
More than, embodiments of the present invention are illustrated.But the present invention is not limited to above embodiment.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution, improvement and etc. done should be included in guarantor of the invention
Within the scope of shield.
Claims (10)
1. a kind of chewable composition containing phosphosilicate glass, which is characterized in that the chewable composition includes matrix
And at least one of phosphosilicate glass, and optionally following components：Sweetener, interfacial agent, plasticizer, is filled out fragrance
Charge and antioxidant.
2. chewable composition according to claim 1, which is characterized in that the weight of each component in the chewable composition
Measuring percentage can be：Matrix 15-93%, phosphosilicate glass 1-52%, sweetener 0-25%, fragrance 0-30%, interface are living
Property agent 0-8%, plasticizer 0-8%, filler material 0-25%, antioxidant 0-0.1%, the sum of each component content be 100%；
Preferably, the weight percent of each component can be in the chewable composition：Matrix 20-88%, phosphosilicate glass
Glass 3-50%, sweetener 0-20%, fragrance 0-25%, interfacial agent 0-3%, plasticizer 0-3%, filler material 0-20% resist
Oxidant 0-0.02%, the sum of each component content are 100%.
3. chewable composition according to claim 1 or 2, which is characterized in that the phosphosilicate glass includes metal
Oxide and nonmetal oxide, wherein the nonmetal oxide is SiO2And P2O5, the metal oxide be calcium, strontium,
One or more of oxides such as magnesium, zinc, sodium, potassium；
Further, the weight percent of each component can be in phosphosilicate glass：SiO240-60%, P2O515-30%,
Metal oxide 20-40%, the sum of each component content are 100%；
Preferably, the group of phosphosilicate glass becomes：SiO245-55%, P2O520-25%, metal oxide 25-35%, respectively
The sum of constituent content is 100%；
Preferably, the phosphosilicate glass is selected from phosphorus calcic silicate glass, phosphorus silicic acid strontium glass, phosphorus magnesium silicate glass, phosphorus silicic acid
One of zinc glass, phosphorus water pearl ash glass, phosphorus water soda glass are a variety of (two or more).
4. chewable composition according to claim 1-3, which is characterized in that the matrix is selected from common alstonia
Glue, processing common alstonia gel matrix, polyvinyl acetate, polyisobutene, one of vinegar natural gum or it is a variety of (two kinds or two kinds with
On)；
Preferably, the sweetener is selected from granulated sugar, glucose, starch sugar, beet sugar, sucrose, maltose, D-sorbite, sweet dew
One of sugar alcohol, xylitol, Aspartame are a variety of (two or more)；
Preferably, the fragrance is selected from one of peppermint, orange, lemon, grapefruit, apple, berry or (two kinds or two kinds a variety of
More than)；
Preferably, the interfacial agent is selected from one of glycerol, vegetable oil, lecithin, two or three；
Preferably, the plasticizer is selected from one or both of microcrystalline wax, animals and plants wax；
Preferably, the filler material be selected from one of calcium carbonate, talcum, sodium sulphate, magnesium sulfate or it is a variety of (two kinds or two kinds with
On)；
Preferably, the antioxidant is selected from tea polyphenols.
5. a kind of chewable object, which is characterized in that the chewable object includes described in any item chewable groups of claim 1-4
Close object；
Preferably, object can be chewed to be made of the chewable composition；
Preferably, the chewable object is chewing gum, bubble gum.
6. the preparation method of the chewable composition described in claim any one of 1-4 containing phosphosilicate glass, feature exist
In the preparation method comprises the following steps：
(1) matrix is heated, or by least one of matrix and optionally following components：Plasticizer and interfacial agent are mixed
It closes, heating；The matrix melted；
(2) it is added in phosphosilicate glass and optionally following components at least in the matrix for the melting that step (1) obtains
It is a kind of：Sweetener, fragrance, antioxidant and filler material, stirring, obtain the chewable composition.
7. the preparation method of chewable composition according to claim 6, which is characterized in that the matrix, phosphosilicate
Glass, sweetener, fragrance, interfacial agent, plasticizer, filler material, antioxidant have claim 2-4 described in any item
Definition.
8. the preparation method of object can be chewed described in claim 5, which is characterized in that the preparation method comprises the following steps：
(1) matrix is heated, or by least one of matrix and optionally following components：Plasticizer and interfacial agent are mixed
It closes, heating；The matrix melted；
(2) it is added in phosphosilicate glass and optionally following components at least in the matrix for the melting that step (1) obtains
It is a kind of：Sweetener, fragrance, antioxidant and filler material, stirring, obtain the chewable composition；
(3) composition for obtaining step (2) carries out extrusion forming, cooling, cutting, aging, packaging, can obtain described chewable
Object.
9. the preparation method of chewable object according to claim 8, which is characterized in that the matrix, phosphosilicate glass,
Sweetener, fragrance, interfacial agent, plasticizer, filler material, antioxidant have the described in any item definition of claim 2-4.
10. the preparation method of chewable object according to claim 8 or claim 9, which is characterized in that in step (1), the heating
Temperature can be 105-165 DEG C, preferably 125-145 DEG C, such as 125 DEG C, 135 DEG C, 145 DEG C；
Preferably, in step (3), the cooling temperature be 10-25 DEG C, preferably 15-20 DEG C, for example, 15 DEG C, 17 DEG C, 19 DEG C,
20℃；
Preferably, in step (3), the aging temperature is 25-30 DEG C, such as 25 DEG C, 30 DEG C；
Preferably, the relative humidity of step (3) can be 45-60%, preferably 50-55%.
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