CN1088086A - A kind of novel skin-protection health products - Google Patents
A kind of novel skin-protection health products Download PDFInfo
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- CN1088086A CN1088086A CN 92114587 CN92114587A CN1088086A CN 1088086 A CN1088086 A CN 1088086A CN 92114587 CN92114587 CN 92114587 CN 92114587 A CN92114587 A CN 92114587A CN 1088086 A CN1088086 A CN 1088086A
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- Prior art keywords
- sod
- skin
- quasi
- health products
- protection health
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Abstract
The invention discloses a kind of skin-protection health products that contains with the intimate quasi-SOD organic compound of natural superoxide dismutase (SOD), these quasi-SOD chemical compounds are to people's no side effects, can be by skin absorbs, participate in human organism's Biochemical processes directly, can remove superoxide ion effectively, to the uncomfortable functions of prevention and health care that rises such as the scytitis that causes by the superoxide ion free radical, allergy, pain.These quasi-SOD chemistries are stable, and its biological activity is not subjected to the influence of factors such as environment for use such as Acidity of Aikalinity, temperature, holding time, no degeneration inactivation, putrid and deteriorated anxiety.This skin-protection health products disclosed by the invention is made simple, stable performance, and effect duration is long.
Description
The present invention relates to a kind of skin-protection health products that contains natural superoxide dismutase (SOD) similar substance, it is specially adapted to remove the superoxide ion free radical that is produced by Biochemical processes in the human body, can prevent the local skin inflammation, allergy and the pain that cause by superoxide ion, play the skin-protection and health-care effect.
Existing traditional skin-protection health products mainly contains easily by the chemical substance of skin absorbs, makes Skin Cell keep enough moisture, with skin care.These quasi-tradition skin care item are not considered the Biochemical processes of human body.Medical research shows that superoxide ion can react with various biomolecule and have toxicity, with physiological phenomenons such as inflammation, cardiovascular diseases, tumor and agings tangible dependency is arranged.Therefore, there are the skin care item that contain natural superoxide dismutase (SOD) to come out in recent years.Natural superoxide dismutase (SOD) is a metalloid enzyme; it protects body to avoid its murder by poisoning by catalysis superoxide ion disproportionation; but natural superoxide dismutase (SOD) its biological activity under non-physiological condition is subjected to the influence of factors such as environment for use, resting period very big; easy degeneration inactivation; putrid and deteriorated, use with preservation condition comparatively harsh.In addition, natural superoxide dismutase (SOD) and molecular weight big, the transdermal ability is difficult to enter subcutaneous, thereby its effect of removing superoxides is limited.
Compare with technology in the past; outstanding progress of the present invention is: one; contain in the skin-protection health products of the present invention and the functionally similar material of natural superoxide dismutase (SOD); these materials are abiotic organic micromolecule compounds; their easy transdermals; participate in the intravital Biochemical processes of people directly; the dismutation reaction of catalysis superoxide ion (Chinese Chemical Letters; 1992; 3(1); 67) remove superoxide ion effectively; the protection body is avoided its evil, to the inflammation that is caused by superoxide ion; irritated; discomforts such as pain have prevention and medical function.Two, the natural superoxide dismutase (SOD) that uses of the present invention though similar substance do not have life but the biological activity height, no degeneration inactivation, putrid and deteriorated shortcoming.Their chemical stability is good, and it removes the influence that superoxide ion effect is not subjected to service condition such as acid-base value, ambient temperature, holding time, occurrence patterns, and service condition is very tolerant, and effect is lasting, effect stability.Three, the similar substance of the natural superoxide dismutase (SOD) of the present invention's use is non-steroid antiinflammation pain-stopping pharmaceutical mefenamic acid, meclofenamic acid an ex hoc genus anne thing, and nonhazardous has no side effect to human body for they.Four, the similar substance mefenamic acid of the natural superoxide dismutase (SOD) of the present invention's use, meclofenamic acid ex hoc genus anne thing itself also has the fungus-proof antisepsis effect, these materials are added among traditional skin care item substrate, can no longer add antiseptic such as benzoic acid etc.
The objective of the invention is to from the Biochemical processes of human body actual, keeping on traditional skin-protection health products basic feature basis, with replacing natural superoxide dismutase (SOD) with the intimate organic molecule medicine of natural superoxide dismutase (SOD), so both guaranteed that skin care item had the removing superoxide ion function of lasting stability, overcome again and used natural superoxide dismutase (SOD) service condition harsh, the changeableness inactivation, shortcoming such as putrid and deteriorated, give full play to these organic molecule pharmaceutical chemistry stable in properties simultaneously, not influenced by service condition, have characteristics such as anticorrosion mildew-proof function.
What the present invention used belongs to diphenylamine compound with the functionally similar organic substance of natural superoxide dismutase (SOD), and its general structure is:
In the formula, R
1, R
2, R
3And R
4Can-CH
3,-CI, substituted radicals such as-COOH.Work as R
1=R
2=CH
3, R
3=H, R
4During=COOH, be the antiinflammation pain-stopping pharmaceutical mefenamic acid; Work as R
1=CH
3, R
2=R
3=CI, R
4It during=COOH meclofenamic acid; Work as R
1=R
2=R
3=H, R
4During=COOH, be vanadium reagents.
The present invention realizes like this, with the similar substance of superoxide dismutase (SOD) such as mefenamic acid, meclofenamic acid ex hoc genus anne thing with the form of former compound or its salt by a certain percentage [as 0.001～1%(W/W)] be added to mixing in the suitable substrate (the various cream emulsions of using as ethanol, water, carboxymethyl cellulose and other traditional skin protection), can make skin-protection health products according to a conventional method with dosage forms such as alcohol, water, powder, book film and various cream emulsions.The whole pH of scalable skin care item is within 7.2～7.4 scopes in case of necessity.In traditional skin-protection health products substrate, add the analog of the superoxide dismutase (SOD) of indication of the present invention, need not special technique measure such as temperature, pressure etc., also need not to change original technology and equipment, can they be added in the later stage of former skin-protection health products manufacture process, as long as guarantee that these analog have good dispersion, dissolubility, and guarantee can not run off to get final product.
Advantage of the present invention is: one, the present invention use with the functionally similar material of natural superoxide dismutase (SOD), the biological activity height, cheap and easy to get.Two, these similar SOD materials of the present invention's use are chemically stable, its function of removing superoxide ion is not subjected to the influence of ambient temperature, Acidity of Aikalinity, resting period, occurrence patterns, natural superoxide dismutase (SOD) easily inactivation degeneration under non-physiological condition, putrid and deteriorated shortcoming have been overcome, can be attached to according to actual needs in the existing skin care item substrate, be extensive use of.Three, enforcement method of the present invention is very simple, need not to increase equipment investment, also need not to change former technological process.
It is as follows to implement preferred example of the present invention:
1, antiinflammatory antiallergic floral water is made up of mefenamic acid or meclofenamic acid (0.1～0.5 gram), dipotaccium glycyrrhizate or ammonium (0.5～1.0 gram), essence (in right amount), pigment (in right amount), 70% ethanol (1000 milliliters).
Its compound method is: restrain mefenamic acid or meclofenamic acid powder 0.5～1.0 gram dipotaccium glycyrrhizate or ammonium with 0.1～0.5 and be dissolved in 300 ml waters, regulating pH with weak ammonia is 7.2～7.4, adds an amount of essence and pigment again, shakes up, add 700 milliliters of anhydrous alcohols at last, shake up.
2, quasi-SOD protective skin cream (breast), deionized water 35.0% an amount of by stearic acid 2.5%, glyceryl monostearate 11.0%, vaseline 10.0%, lanoline 22.0%, hexadecanol 1.5%, liquid paraffin wax 9.0%, Polyethylene Glycol (1500) 3%, triethanolamine 1%, mefenamic acid sodium or meclofenamate sodium 0.02%, dipotaccium glycyrrhizate 0.05%, essence formed.
Its method for production is: except that mefenamic acid sodium or meclofenamate sodium, dipotaccium glycyrrhizate, essence, with the manufacture method dissolving routinely of other material, mixed, emulsifying and then add mefenamic acid sodium or meclofenamate sodium, dipotaccium glycyrrhizate, essence, continuation emulsifying to even cooling gets final product.
Claims (3)
1, is the skin-protection health products that contains the quasi-SOD material of substrate by traditional skin protection with cream emulsion and ethanol, it is characterized in that containing the organic micromolecule compound with natural superoxide dismutase (SOD) identity function, in that chemically it belongs to the diphenylamine derivant.
2, the strong product of skin protection that contain the quasi-SOD material according to claim 1 is characterized in that diphenylamine derivatives chemical general structure is
In the general formula, R
1, R
2, R
3And R
4Mainly be H, CH
3, CI, substituted radical and combinations thereof such as COOH.
3, the skin-protection health products that contains the quasi-SOD material according to claim 1 is characterized in that employed organic micromolecule compound is a non-steroid antiinflammation pain-stopping pharmaceutical mefenamic acid, meclofenamic acid and its congener with and alkali metal salt and ammonium salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114587 CN1088086A (en) | 1992-12-14 | 1992-12-14 | A kind of novel skin-protection health products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114587 CN1088086A (en) | 1992-12-14 | 1992-12-14 | A kind of novel skin-protection health products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1088086A true CN1088086A (en) | 1994-06-22 |
Family
ID=4947017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92114587 Pending CN1088086A (en) | 1992-12-14 | 1992-12-14 | A kind of novel skin-protection health products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1088086A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998058636A1 (en) * | 1997-06-20 | 1998-12-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
-
1992
- 1992-12-14 CN CN 92114587 patent/CN1088086A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998058636A1 (en) * | 1997-06-20 | 1998-12-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| US6395725B1 (en) | 1997-06-20 | 2002-05-28 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |