CN108801752B - Sample loading device and sample driving device - Google Patents
Sample loading device and sample driving device Download PDFInfo
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- CN108801752B CN108801752B CN201810871409.9A CN201810871409A CN108801752B CN 108801752 B CN108801752 B CN 108801752B CN 201810871409 A CN201810871409 A CN 201810871409A CN 108801752 B CN108801752 B CN 108801752B
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- sample
- test tube
- annular boss
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- magnetic
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- 238000012360 testing method Methods 0.000 claims abstract description 66
- 239000011324 bead Substances 0.000 claims description 27
- 238000003325 tomography Methods 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 8
- 238000005259 measurement Methods 0.000 abstract description 7
- 238000009434 installation Methods 0.000 abstract description 4
- 230000003287 optical effect Effects 0.000 description 9
- 230000006872 improvement Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 230000032683 aging Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005389 magnetism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The application discloses a sample loading device and a sample driving device, wherein the sample loading device comprises a sample fixing module, a test tube module and a loading table, a stepped through hole is formed in the middle of the loading table, a first annular boss and a second annular boss are arranged in the stepped through hole, the sample fixing module comprises a circular panel and a straight rod, the test tube module is magnetically buckled on the upper surface of the second annular boss, the panel of the sample fixing module is magnetically buckled on the upper surface of the first annular boss, and the straight rod can be inserted into the test tube module. The application realizes the installation connection between the test tube module and the loading table and between the sample fixing module and the loading table in a magnetic attraction mode, improves the convenience and the accuracy of operation in the application process of the device, and improves the measurement accuracy. The sample driving device installs the sample to be measured on the rotating assembly through the sample loading device, so that the convenience of device operation in the application process is improved, and the accuracy of tomography measurement is improved.
Description
Technical Field
The application relates to the technical field of optical projection tomography devices, in particular to a sample loading device and a sample driving device applied to an optical projection tomography system.
Background
Optical projection tomography (optical projection tomography) is a novel three-dimensional imaging technique for small biological specimens that uses optical scavengers to clean or transparent samples to calculate three-dimensional structures using ultraviolet, visible and near infrared spectra to transmit photons through the sample.
At present, a sample loading scheme of an optical projection tomography system mainly utilizes an open-pore rubber plug, a sample fixing device penetrates through a through hole in the rubber plug, a sample to be measured is fixed on the sample fixing device, the rubber plug is finally plugged into a test tube port, the sample to be measured is placed in a test tube, and finally the whole test tube is placed on an imaging system for measurement.
The existing sample loading scheme has the advantages that the required loading assembly is simple and low in cost, but has the defects that the rubber plug is easy to age due to the influence of environment or use times, so that the through hole of the rubber plug is deformed, a sample to be tested in a test tube is easy to deviate from the center position, and after the rubber plug is plugged into a port of the test tube, the rubber plug is inclined to a certain extent to a greater or lesser extent, so that the sample to be tested in the test tube is easy to deviate from the center position, the depth of field of the sample to be tested is easy to deviate from the depth of field in the rotation process of the test tube, and the accuracy of projection data is influenced.
Disclosure of Invention
The application aims to solve the technical problems that: due to the deformation of the rubber stopper itself and the inclination of the rubber stopper when the rubber stopper is loaded onto the test tube, the sample to be tested inside the test tube is deviated from the center position.
The application solves the technical problems as follows:
the utility model provides a be applied to optical projection tomography imaging system's sample loading device, includes sample fixed module, test tube module and loading table, loading table middle part position is equipped with the ladder through-hole, top-down is equipped with first annular boss and second annular boss in proper order in the ladder through-hole, first annular boss and second annular boss centre of a circle are the same point, second annular boss height is greater than first annular boss height, sample fixed module includes circular panel and straight stick, and the sample that awaits measuring is fixed in straight stick bottom when using, straight stick is installed in panel bottom centre of a circle position department, test tube module magnetism lock is at second annular boss upper surface, sample fixed module's panel magnetism lock is at first annular boss upper surface, straight stick can insert test tube module inside.
As a further improvement of the above technical solution, the test tube module includes a test tube and a test tube fixing ring, where the test tube fixing ring is fastened on the upper surface of the second annular boss; the wall thickness of the test tube fixing ring gradually increases from top to bottom, the test tube comprises a tube body and a limiting part arranged at the top of the tube body, the inner ring size of the test tube fixing ring is matched with the tube body size of the test tube, and the limiting part is in surface contact with the inner wall of the test tube fixing ring.
As a further improvement of the technical scheme, a plurality of first magnetic beads are arranged on the upper surface of the second annular boss, a plurality of first magnetic concave positions matched with the first magnetic beads are arranged at the bottom of the test tube fixing ring, and when the test tube fixing ring is buckled on the second annular boss, the first magnetic beads are magnetically connected with the first magnetic concave positions.
As a further improvement of the technical scheme, a plurality of second magnetic concave positions are formed in the upper surface of the first annular boss, a plurality of second magnetic beads matched with the second magnetic concave positions are arranged at the bottom of the panel of the sample fixing module, and when the bottom of the panel of the sample fixing module is buckled on the upper surface of the first annular boss, the second magnetic beads are magnetically connected with the second magnetic concave positions.
The beneficial effects of the application are as follows: the application realizes the installation connection between the test tube module and the loading table and between the sample fixing module and the loading table in a magnetic attraction mode, avoids the technical problem of deformation caused by aging of the rubber plug in the prior art, improves the convenience and the accuracy of operation in the application process of the device, and improves the accuracy of measurement.
The application also discloses a sample driving device which comprises a lifting component, a rotating component, a three-dimensional adjusting component and the sample loading device, wherein the rotating component is arranged on the lifting component, the three-dimensional adjusting component is arranged on the rotating component, and the sample loading device is arranged on the three-dimensional adjusting component.
As a further improvement of the technical scheme, a plurality of third magnetic beads are arranged on the upper surface of the loading table, the third magnetic beads are distributed in an annular array by taking the center of the loading table as the circle center, a plurality of third magnetic concave positions matched with the third magnetic beads are arranged at the bottom of the three-dimensional adjusting assembly, and when the sample loading device is arranged at the bottom of the three-dimensional adjusting assembly, the third magnetic beads are magnetically connected with the third magnetic concave positions.
The beneficial effects of the application are as follows: according to the application, the sample to be measured is mounted on the rotating assembly through the sample loading device, and the position of the sample loading device is regulated through the three-dimensional regulating assembly, so that the sample to be measured is ensured to be accurately fixed at the rotating central shaft position of the rotating assembly, the convenience of device operation in the application process is improved, and the accuracy of tomography measurement is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings that are required to be used in the description of the embodiments will be briefly described below. It is evident that the drawings described are only some embodiments of the application, but not all embodiments, and that other designs and drawings can be obtained from these drawings by a person skilled in the art without inventive effort.
FIG. 1 is a schematic view of a sample loading device according to the present application;
FIG. 2 is a schematic diagram of a sample driving apparatus according to the present application.
Detailed Description
The conception, specific structure, and technical effects produced by the present application will be clearly and completely described below with reference to the embodiments and the drawings to fully understand the objects, features, and effects of the present application. It is apparent that the described embodiments are only some embodiments of the present application, but not all embodiments, and that other embodiments obtained by those skilled in the art without inventive effort are within the scope of the present application based on the embodiments of the present application. In addition, all coupling/connection relationships mentioned herein do not refer to direct connection of the components, but rather, refer to the fact that a more optimal coupling structure may be formed by adding or subtracting coupling aids depending on the particular implementation. The technical features in the application can be interactively combined on the premise of no contradiction and conflict.
Referring to fig. 1, aiming at the defect of a sample loading scheme of an optical projection tomography system in the prior art, the application creates and discloses a sample loading device applied to the optical projection tomography system, which comprises a sample fixing module, a test tube module and a loading table 1, wherein a stepped through hole 11 is arranged in the middle of the loading table 1, a first annular boss 12 and a second annular boss 13 are sequentially arranged in the stepped through hole 11 from top to bottom, the centers of the first annular boss 12 and the second annular boss 13 are at the same point, the height of the second annular boss 13 is larger than that of the first annular boss 12, namely, the radius of a circle surrounded by the first annular boss 12 is larger than that of a circle surrounded by the second annular boss 13, the sample fixing module comprises a circular panel 21 and a straight bar 22, when the sample to be measured is fixed at the bottom of the straight bar 22, the straight bar 22 is arranged at the position of the center of the bottom of the panel 21, the test tube module is magnetically buckled on the upper surface of the second annular boss 13, the panel 21 of the sample fixing module is magnetically buckled on the upper surface of the first annular boss 12, and the straight bar 22 can be inserted into the test tube module. Specifically, the application realizes the installation connection between the test tube module and the loading table 1 and between the sample fixing module and the loading table 1 in a magnetic attraction mode, avoids the technical problem of deformation caused by aging of the rubber plug in the prior art, improves the convenience and accuracy of operation in the application process of the device, and improves the accuracy of measurement.
Further as a preferred embodiment, the application creates a specific embodiment, the test tube module includes a test tube 31 and a test tube fixing ring 32, and the test tube fixing ring 32 is buckled on the upper surface of the second annular boss 13; the wall thickness of the test tube fixing ring 32 gradually increases from top to bottom, the test tube 31 comprises a tube body 312 and a limiting part 311 arranged at the top of the tube body 312, the inner ring size of the test tube fixing ring 32 is matched with the tube body 312 of the test tube 31 in size, and the limiting part 311 is in contact with the inner side wall surface of the test tube fixing ring 32. More specifically, the contact surface between the limiting part 311 of the test tube 31 and the inner side wall of the test tube fixing ring 32 is in an arc structure, and the convenience of device operation and the stability of the test tube 31 in the application process are effectively improved through the arrangement.
Further as a preferred embodiment, the application creates a specific embodiment, the upper surface of the second annular boss 13 is provided with a plurality of first magnetic beads 14, the bottom of the test tube fixing ring 32 is provided with a plurality of first magnetic concave positions matched with the first magnetic beads 14, and when the test tube fixing ring 32 is buckled on the second annular boss 13, the first magnetic beads 14 are magnetically connected with the first magnetic concave positions. Specifically, after the fixed ring 32 lock of test tube is at second annular boss 13, the fixed ring 32 bottom of test tube is laminated mutually with second annular boss 13 upper surface, the fixed ring 32 top of test tube flushes with first annular boss 12 upper surface, has guaranteed the fixed ring of test tube 32 and has installed the fastness between loading table 1, still facilitates the user to dismantle it.
Further as a preferred embodiment, the application creates a specific embodiment, the upper surface of the first annular boss 12 is provided with a plurality of second magnetic concave positions 15, the bottom of the panel 21 of the sample fixing module is provided with a plurality of second magnetic beads matched with the second magnetic concave positions 15, and when the bottom of the panel 21 of the sample fixing module is buckled on the upper surface of the first annular boss 12, the second magnetic beads are magnetically connected with the second magnetic concave positions 15. Specifically, after the bottom of the panel 21 of the sample fixing module is buckled on the upper surface of the first annular boss 12, the bottom of the panel 21 is attached to the upper surface of the first annular boss 12, and the top of the panel 21 is flush with the upper surface of the loading table 1, so that the convenience is brought to a user to detach the sample fixing module while the mounting firmness between the sample fixing module and the loading table 1 is ensured.
Referring to fig. 2, the application also discloses a sample driving device, which comprises a lifting assembly 4, a rotating assembly 5, a three-dimensional adjusting assembly 6 and the sample loading device, wherein the rotating assembly 5 is arranged on the lifting assembly 4, the three-dimensional adjusting assembly 6 is arranged on the rotating assembly 5, and the sample loading device is arranged on the three-dimensional adjusting assembly 6. Specifically, lifting assembly 4 is used for adjusting the height of sample that awaits measuring, guarantees that the sample that awaits measuring is in suitable position in carrying out tomography in-process, rotating assembly 5 is used for realizing the rotation operation of sample that awaits measuring, realizes the multi-angle image acquisition operation of sample that awaits measuring, three-dimensional adjusting assembly 6 is used for carrying out fine adjustment to the position of sample that awaits measuring, guarantees that the sample that awaits measuring is located the rotation center pin of rotating assembly 5. In addition, in the embodiment of the present application, the rotating assembly 5 is not directly mounted on the lifting assembly 4, but the rotating assembly 5 is mounted and connected with the lifting assembly 4 through a connecting member 7.
According to the application, the sample to be detected is arranged on the rotating assembly 5 through the sample loading device, the position of the sample loading device is regulated through the three-dimensional regulating assembly 6, the sample to be detected is ensured to be accurately fixed at the rotating central shaft position of the rotating assembly 5, the convenience of device operation in the application process is improved, and the accuracy of tomography measurement is improved.
Further as a preferred embodiment, the application creates a specific embodiment, the upper surface of the loading table 1 is provided with a plurality of third magnetic beads 16, the third magnetic beads 16 are distributed in an annular array with the center of the loading table 1 as the center of the circle, the bottom of the three-dimensional adjusting component 6 is provided with a plurality of third magnetic concave positions matched with the third magnetic beads 16, and when the sample loading device is installed at the bottom of the three-dimensional adjusting component 6, the third magnetic beads 16 are magnetically connected with the third magnetic concave positions. After the buckling is completed, the bottom of the three-dimensional adjusting assembly 6 is attached to the upper surface of the loading table 1, so that the installation firmness between the three-dimensional adjusting assembly 6 and the loading table 1 is guaranteed, and a user can conveniently detach the three-dimensional adjusting assembly.
While the preferred embodiment of the present application has been described in detail, the application is not limited to the embodiments, and various equivalent modifications and substitutions can be made by those skilled in the art without departing from the spirit of the application, and these modifications and substitutions are intended to be included in the scope of the present application as defined in the appended claims.
Claims (4)
1. A sample loading device, characterized in that: the test tube fixing device comprises a sample fixing module, a test tube module and a loading table (1), wherein a stepped through hole (11) is formed in the middle of the loading table (1), a first annular boss (12) and a second annular boss (13) are sequentially formed in the stepped through hole (11) from top to bottom, the centers of the first annular boss (12) and the second annular boss (13) are at the same point, the height of the second annular boss (13) is larger than that of the first annular boss (12), the sample fixing module comprises a circular panel (21) and a straight rod (22), the straight rod (22) is arranged at the center of the bottom of the panel (21), the test tube module is magnetically buckled on the upper surface of the second annular boss (13), the panel (21) of the sample fixing module is magnetically buckled on the upper surface of the first annular boss (12), and the straight rod (22) can be inserted into the test tube module;
the test tube module comprises a test tube (31) and a test tube fixing ring (32), and the test tube fixing ring (32) is buckled on the upper surface of the second annular boss (13); the wall thickness of the test tube fixing ring (32) gradually increases from top to bottom, the test tube (31) comprises a tube body (312) and a limiting part (311) arranged at the top of the tube body (312), the inner ring size of the test tube fixing ring (32) is matched with the tube body (312) size of the test tube (31), and the limiting part (311) is in contact with the inner side wall surface of the test tube fixing ring (32);
the device is characterized in that a plurality of second magnetic concave positions (15) are arranged on the upper surface of the first annular boss (12), a plurality of second magnetic beads matched with the second magnetic concave positions (15) are arranged at the bottom of the panel (21) of the sample fixing module, and when the bottom of the panel (21) of the sample fixing module is buckled on the upper surface of the first annular boss (12), the second magnetic beads are magnetically connected with the second magnetic concave positions (15).
2. A sample loading device according to claim 1, wherein: the test tube fixing device is characterized in that a plurality of first magnetic beads (14) are arranged on the upper surface of the second annular boss (13), a plurality of first magnetic concave positions matched with the first magnetic beads (14) are arranged at the bottom of the test tube fixing ring (32), and the first magnetic beads (14) are magnetically connected with the first magnetic concave positions when the test tube fixing ring (32) is buckled on the second annular boss (13).
3. A sample driving device, characterized in that: the sample loading device comprises a lifting assembly (4), a rotating assembly (5), a three-dimensional adjusting assembly (6) and any one of claims 1 to 2, wherein the rotating assembly (5) is installed on the lifting assembly (4), the three-dimensional adjusting assembly (6) is installed on the rotating assembly (5), and the sample loading device is installed on the three-dimensional adjusting assembly (6).
4. A sample driving device according to claim 3, wherein: the three-dimensional magnetic loading device is characterized in that a plurality of third magnetic beads (16) are arranged on the upper surface of the loading table (1), the third magnetic beads (16) are distributed in an annular array by taking the center of the loading table (1) as the center of a circle, a plurality of third magnetic concave positions matched with the third magnetic beads (16) are arranged at the bottom of the three-dimensional adjusting assembly (6), and the third magnetic beads (16) are magnetically connected with the third magnetic concave positions when the sample loading device is arranged at the bottom of the three-dimensional adjusting assembly (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810871409.9A CN108801752B (en) | 2018-08-02 | 2018-08-02 | Sample loading device and sample driving device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810871409.9A CN108801752B (en) | 2018-08-02 | 2018-08-02 | Sample loading device and sample driving device |
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| CN108801752A CN108801752A (en) | 2018-11-13 |
| CN108801752B true CN108801752B (en) | 2023-11-28 |
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