CN108786633A - A kind of liquid preparation continuous-blending equipment and method - Google Patents
A kind of liquid preparation continuous-blending equipment and method Download PDFInfo
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- CN108786633A CN108786633A CN201810752057.5A CN201810752057A CN108786633A CN 108786633 A CN108786633 A CN 108786633A CN 201810752057 A CN201810752057 A CN 201810752057A CN 108786633 A CN108786633 A CN 108786633A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/405—Methods of mixing liquids with liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/43—Mixing liquids with liquids; Emulsifying using driven stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/49—Mixing systems, i.e. flow charts or diagrams
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/2201—Control or regulation characterised by the type of control technique used
- B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
Abstract
The invention discloses a kind of liquid preparation continuous-blending equipment and methods, liquid preparation continuous-blending equipment in the present invention can realize charging, mixing and discharging while is carried out continuously under the control action of the first control valve and the second control valve, and interval preset time monitors the physical and chemical parameter of multiple monitoring points under the effect of sampling monitoring device, to ensure that liquid preparation is met the requirements, to ensure that discharging homogeneity.Due to the present invention liquid preparation continuous-blending equipment can continuous production, realize with the period divide production batch.Compared with prior art, the small relatively small equipment of occupied area, which may be used, can improve production efficiency, to improve the utilization rate of workshop.
Description
Technical field
The present invention relates to liquid preparation preparation technique fields, and more specifically to a kind of liquid preparation, continuously mixing is set
Standby and method.
Background technology
Existing liquid preparation production method is batch production model, and each batch actual production of this production model takes not
Long, the most of the time is used for the transfer and inspection of product, and for improving production efficiency, the way of most of enterprise is to increase single batch
Secondary injected volume reaches shortening time raising efficiency to down-sample number and intermediate product amount of testing.But using such production
Pattern needs more transfer containers, equipment occupation space is increased, to reduce workshop utilization rate；In addition, since transfer is held
Device increases, and when cleaning can cause more sewage discharges, meanwhile, increase the procedure quality risk of cleaning validity.
Therefore, workshop utilization rate is improved while how improving production efficiency, it is urgently to be resolved hurrily to become those skilled in the art
The technical issues of.
Invention content
It is utilized in view of this, improving workshop while the technical problem to be solved by the present invention is to how improve production efficiency
Rate, for this purpose, the present invention provides a kind of liquid preparation continuous-blending equipment and liquid preparation method for continuously mixing.
To achieve the above object, the present invention provides the following technical solutions：
A kind of liquid preparation continuous-blending equipment, including：
First blending tank, for holding simultaneously mixing liquid preparation；
The bottom of second blending tank, second blending tank is connected to by communicating pipe with the bottom of first blending tank；
First control valve is arranged between the feed inlet and liquid mixing system of first blending tank, with control through matching liquid system
Liquid preparation after system under unified central planning is exported to first blending tank；
Second control valve is arranged between the discharge port and bulking system of the second blending tank liquid, after controlling mixing
Liquid preparation export to the bulking system；
Sampling monitoring device, the physical and chemical parameter for monitoring the liquid preparation of multiple monitoring points for being spaced preset time；
It is corresponding with the correspondence of monitoring point to obtain each monitoring point according to the preset time, physical and chemical parameter for controller
Physical and chemical index, according to the physical and chemical index and level threshold value, output control signals to the first control control valve control terminal and
The control terminal of second control valve, to control the keying of first control valve and second control valve.
Preferably, in aforesaid liquid preparation continuous-blending equipment, the middle part of second blending tank by circulation pipe with
The middle part of first blending tank is connected to, and circulating pump is provided at the circulation pipe.
Preferably, in aforesaid liquid preparation continuous-blending equipment, the position of the circulation pipe is arranged in first blending tank
At the 2/3 of first blending tank；The position that the circulation pipe is arranged in second blending tank is mixed positioned at described second
At close tank 2/3.
Preferably, in aforesaid liquid preparation continuous-blending equipment, being internally provided with for first blending tank first is stirred
Mix system；Second blending tank is internally provided with the second stirring system.
Preferably, in aforesaid liquid preparation continuous-blending equipment, the connection of the communicating pipe and second blending tank
Bottom of the place higher than second stirring system.
Preferably, in aforesaid liquid preparation continuous-blending equipment, the physical and chemical parameter includes pH value, soluble solid
Content, polyoses content and run time.
Preferably, in aforesaid liquid preparation continuous-blending equipment, the multiple monitoring point includes being located at described first to mix
Close the first monitoring point at the feed inlet of tank, the second monitoring point at the communicating pipe, positioned at second blending tank
The third monitoring point of discharge outlet and the 4th monitoring point at the circulation pipe.
The invention also discloses a kind of liquid preparation method for continuously mixing, the method is using as described in any one of the above embodiments
Liquid preparation continuous-blending equipment, the method includes：
Preset standard threshold value；
Interval preset time monitors the physical and chemical parameter of the liquid preparation of multiple monitoring points；
The corresponding physics and chemistry in each monitoring point is obtained according to the preset time, physical and chemical parameter and the correspondence of monitoring point to refer to
Mark, with the physical and chemical index whether not in level threshold value for condition, obtain first control valve and second control valve
It is enough to have the judgement of conditions for use as a result, when judgement result characterizes first control valve and second control valve does not have
When conditions for use, the control signal of first control valve and second control valve is opened in output.
Preferably, in aforesaid liquid preparation method for continuously mixing, the physical and chemical parameter includes pH value, soluble solid
Content, polyoses content and run time；
The level threshold value includes PH level threshold values, soluble solid content level threshold value, polyoses content level threshold value
With the temporary time limit；
Wherein, the pH value is on-line monitoring, and the soluble solid content and polyoses content are off-line monitoring.
Preferably, in aforesaid liquid preparation method for continuously mixing, the pH value is supervised online using plum Teller 3250
It surveys；The soluble solid content carries out off-line monitoring using Rudolph refractometers；The polyoses content uses potassium permanganate
Titration carries out off-line monitoring；The temporary time limit is obtained using challenge experiment and online verification.
It can be seen from the above technical scheme that liquid preparation continuous-blending equipment in the present invention in the first control valve and
Charging, mixing and discharging can be realized under the control action of second control valve while being carried out continuously, and are acted in sampling monitoring device
Lower interval preset time monitors the physical and chemical parameter of multiple monitoring points, to ensure that liquid preparation is met the requirements, to ensure that discharging
Homogeneity.Due to the present invention liquid preparation continuous-blending equipment can continuous production, realize with the period divide production batch
It is secondary.Compared with prior art, the small relatively small equipment of occupied area, which may be used, can improve production efficiency, to improve
The utilization rate of workshop.
In addition, additional transfer container is not needed substantially using the equipment in the present invention, to reduce due in cleaning
Turn that container is invalid and the quality risk that generates.It is carried out at the same time monitoring by the way that multiple monitoring points are arranged, can ensure liquid preparation
While quality, excessively supervision is reduced, supervision resource is concentrated on to the field of more high risk, more meaningful statistical data is provided
With more stable technology controlling and process.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
Obtain other attached drawings according to these attached drawings.
A kind of structural schematic diagram for liquid preparation continuous-blending equipment that Fig. 1 is provided by the embodiment of the present invention；
A kind of flow diagram for liquid preparation method for continuously mixing that Fig. 2 is provided by the embodiment of the present invention.
Wherein, 100 it is liquid mixing system, 200 be liquid preparation continuous-blending equipment, 300 be bulking system, 201 is first
Blending tank, 202 be the second blending tank, 203 be the first control valve, 204 be the second control valve, 205 be communicating pipe, 206 be cycle
Pipe, 207 be circulating pump, 208 be the device in order to control of sampling monitoring device, 209.
Specific implementation mode
Traditional oral liquid formulations production model is batch production model, i.e., can all pause among every procedure and do centre
Detection can just enter the next step after qualified.This production model is long there are the production time, and inventory is high, and a large amount of libraries
It deposits and is in intermediate product, directly contribute interrupted production, change and criticize the shortcomings of time is long, production loss is high.But due to production regulation
Regulation (2017 editions《Health food production permit examines detailed rules and regulations》In 5.2 regulation, " * 5.2 enterprises should establish production batch managing system
Degree, health food are produced according to same process tissue, through homogeneous caused by same equipment mixed once before being molded or is filling
Product should work out unique product batch number.The continuous production within the same production cycle, it can be ensured that the health care of product homogenisation is eaten
Product can work out same product batch number.") and oral liquid formulations there is no standardized device and method in continuous production field, this
When most enterprises in order to reduce intermediate survey number, can only allow production batch become increasing, cause plant area more to make
Bigger, transfer container tool is more and more, directly results in the new problems such as investment cost height, the low, malfunction of workshop utilization ratio.
Currently, the continuous production of raw material is easier to realize, it is fine chemistry industry that raw material dries packet leading portion in essence after all
Operation, software, hardware condition are more perfect, but are to have certain technology to want from raw material serialization to liquid preparation serialization
It asks, mainly raw material production and preparation production is usually in different local or even different companies, still《Health food production is permitted
It can examine detailed rules and regulations》It clearly carries and releasing new regulation, i.e., full process commission production, this is the matter of intermediate product (preparing liquid) before liquid preparation
Amount stability provides guarantee, while also providing achievable prerequisite for liquid preparation continuous production；National legislation
It is specific as follows there has also been relevant mating support：
A.《Pharmaceutical production quality management practices》2010 the 31st article of revised edition annex bulk pharmaceutical chemicals are mixed about intermediate product
Description：The intermediate products of several batches are merged to the component part for doing further processing together and can be used as production technology, are not regarded
For mixing；
B.《Health food production permit examines detailed rules and regulations》Regulation：The continuous production within the same production cycle, it can be ensured that production
The health food of product homogeneous can work out same product batch number.
On above-mentioned background, core of the invention is to provide a kind of liquid preparation continuous-blending equipment and method,
Workshop utilization rate is improved while to improve production efficiency.
In addition, embodiments illustrated below does not play any restriction effect to the invention described in the claims content.In addition,
The full content of composition represented by following example is not limited to must as the solution of the invention described in the claims
It needs.
It please refers to Fig.1 to Fig. 2, the liquid preparation continuous-blending equipment 200 of embodiment is applied in liquid mixing system in the present invention
Between 100 and bulking system 300, filling system is delivered to after the liquid preparation that liquid mixing system 100 is prepared is sufficiently mixed uniformly
It unites 300 embeddings, finally realizes continuous production.
The liquid preparation continuous-blending equipment 200 (follow-up abbreviation mixing apparatus 200) of the embodiment of the present invention includes：
First blending tank 201, for holding simultaneously mixing liquid preparation, it is defeated which receives liquid mixing system 100
The liquid preparation brought can carry out mixture operation under 201 self structure of the first blending tank；
The bottom of second blending tank 202, the second blending tank 202 is connected by the bottom of communicating pipe 205 and the first blending tank 201
It is logical；
First control valve 203 is arranged between the feed inlet and liquid mixing system 100 of the first blending tank 201, to control through matching
Liquid preparation after liquid system 100 is prepared is exported to the first blending tank 201；
Second control valve 204 is arranged between the discharge port and bulking system 300 of 202 liquid of the second blending tank, mixed to control
Liquid preparation after even is exported to bulking system 300；
Sampling monitoring device 208, the physical and chemical parameter for monitoring the liquid preparation of multiple monitoring points for being spaced preset time；
It is corresponding with the correspondence of monitoring point to obtain each monitoring point according to preset time, physical and chemical parameter for controller 209
Physical and chemical index outputs control signals to control terminal and the second control of the first control control valve according to physical and chemical index and level threshold value
The control terminal of valve 204 processed, to control the keying of the first control valve 203 and the second control valve 204.
The control of liquid preparation continuous-blending equipment 200 in the present invention in the first control valve 203 and the second control valve 204
Charging, mixing and discharging can be realized under effect while being carried out continuously, and are spaced preset time under the effect of sampling monitoring device 208
The physical and chemical parameter for monitoring multiple monitoring points, to ensure that liquid preparation is met the requirements, to ensure that discharging homogeneity.Due to this hair
Bright liquid preparation continuous-blending equipment 200 can continuous production, realize with the period divide production batch.With the prior art
It compares, the small relatively small equipment of occupied area, which may be used, can improve production efficiency, to improve the utilization rate of workshop.
In addition, additional transfer container is not needed substantially using the equipment in the present invention, to reduce due in cleaning
Turn that container is invalid and the quality risk that generates.It is carried out at the same time monitoring by the way that multiple monitoring points are arranged, can ensure liquid preparation
While quality, excessively supervision is reduced, supervision resource is concentrated on to the field of more high risk, more meaningful statistical data is provided
With more stable technology controlling and process.
In order to improve the mixing quality of the mixing apparatus 200, the middle part of the second blending tank 202 passes through circulation pipe 206 and
The middle part of one blending tank 201 is connected to, and circulating pump 207 is provided at circulation pipe 206.The bottom of first blending tank 201 is mixed with second
The bottom for closing tank 202 is connected by communicating pipe 205, and middle part is attached by circulation pipe 206, therefore, into the first blending tank
Liquid preparation in 201 can be freely delivered in the second blending tank 202 by communicating pipe 205, the liquid system in the second blending tank 202
Agent is entered to by circulation pipe 206 in the first blending tank 201 under the action of circulating pump 207, at this time the first blending tank 201 and
Two blending tanks 202 form a circulation loop.
In aforesaid liquid preparation continuous-blending equipment 200, the first blending tank 201 is internally provided with the first stirring system
System；Second blending tank 202 is internally provided with the second stirring system.By the way that the first stirring system and the second stirring system is arranged,
The liquid preparation in respective system can be uniformly mixed in first blending tank 201 and the second blending tank 202, meanwhile, it is defeated each other
Cycle is sent to form a big mixed system, at this point, the liquid preparation in the first blending tank 201 and the second blending tank 202 is phase
It is same and uniform.
In addition, in order to enable the liquid preparation entered in the second blending tank 202 by the first blending tank 201 being capable of maximum limit
Degree is mixed with the liquid preparation in the second blending tank 202, and communicating pipe 205 and the junction of the second blending tank 202 are stirred higher than second
Mix the bottom of system.Further, the position of the first blending tank 201 setting circulation pipe 206 is located at the first blending tank 201
At 2/3；The position of second blending tank 202 setting circulation pipe 206 is located at the 2/3 of the second blending tank 202.
Syrup class of the liquid preparation of the present invention mainly for water-soluble inorganic salt, water soluble organic salt and low viscosity.Needle
It is different to different liquid preparation physical and chemical parameters, physical and chemical parameter include relative density, pH value, soluble solid content,
It is one or more in polyoses content, viscosity and run time；The relative density of aforesaid liquid preparation：1~1.05 (20/4 DEG C)；
Solid content：0~30%；PH：3~10；Polyoses content：0~1500mg/100ml；Viscosity：1~10cp (20 DEG C).
Liquid preparation is mainly for the syrup class of low viscosity in the embodiment of the present invention, and physical and chemical parameter includes pH value, solvable
Property solid content, polyoses content and run time.In view of the stability of current on-line monitoring technique, PH can realize online prison
It surveys, soluble solid and polyoses content use offline periodic monitor.
It is more ripe in PH on-line monitoring equipment and the current industry of software, 3250 model of plum Teller may be selected, it can be achieved that in real time
It monitors and automatically records；Soluble solid uses offline sampling monitoring, and detection is primary per hour, and Rudolph refractive powers may be selected
Instrument, later stage can gradually extend the assay intervals time according to the stable case of technique；Polyoses content is monitored using offline chemical method, often
Hour detection is primary, permanganimetric method may be selected, when the later stage can gradually extend assay intervals according to the stable case of technique
Between.
In order to improve the mixing quality of liquid preparation, in the embodiment of the present invention, multiple monitoring points can be arranged mixed first
It closes at tank 201, at the second blending tank 202, at communicating pipe 205, at circulation pipe 206, in the embodiment of the present invention, is saved to reach
Monitoring device is monitored using intermediate portions emphasis.Specifically, multiple monitoring points include being located at the first mixing in the embodiment of the present invention
The first monitoring point A at the feed inlet of tank 201, the second monitoring point B at communicating pipe 205, positioned at the second blending tank 202
The third monitoring point C of discharge outlet and the 4th monitoring point D at circulation pipe 206.According to liquid in entire mixing apparatus 200
The flow direction of body preparation, above-mentioned 4 monitoring points are located at " after in preceding " three of 200 liquid preparation of entire mixing apparatus flow direction
A stage, the fluctuation situation of physical and chemical parameter can reflect the uniform situation of the liquid preparation in entire mixing apparatus 200, dynamic
Under the conditions of each monitoring point physical and chemical index in standard limits, illustrate that all liq preparation reaches uniform in mixing apparatus 200
Change and requires.
In addition, when due to above-mentioned 200 continuous production of mixing apparatus, which can be in strip shape for a long time
State, therefore, it is necessary to carry out the temporary time limit of liquid preparation to be verified, and main method is challenge experiment and online verification.Its
In, challenge experiment：The directly grab sample from above-mentioned mixing apparatus 200, room temperature storage (do not recycle mixing) under static conditions and send
Inspection, until any abnormal end of overall merits such as microorganism, material sense organ, physical and chemical parameter, when obtaining the longest under the conditions of challenging
It limits (this longest time limit is different because of the kind of product and production environment)；Online verification：The on-line period in above-mentioned mixing apparatus 200
Inspection, index confirm the longest continuous production time under normal production conditions with experiment is challenged, and are obtained most according to challenge experiment
The longest continuous production time that long time limit and online verification obtain, the temporary time limit of liquid preparation is obtained, for following production batch
Number formulate provide technological basis.Meanwhile the run time of entire mixing apparatus 200 is no more than the temporary time limit.
Referring to Fig. 2, the invention also discloses a kind of liquid preparation method for continuously mixing, method applies such as any of the above-described
Liquid preparation continuous-blending equipment 200, this method includes：
Step S1, preset standard threshold value；Level threshold value has mostly not according to different liquid preparations in embodiments of the present invention
Together, in general, level threshold value includes relative density level threshold value, PH level threshold values, soluble solid content level threshold value, polysaccharide
Content standard threshold value, viscosity criterion threshold value and one or more in the temporary time limit.According to different liquids standard preparation threshold value
It chooses and differs, for the syrup class for choosing low viscosity in embodiments of the present invention, level threshold value includes PH level threshold values, can
Dissolubility solid content level threshold value, polyoses content level threshold value and temporary time limit.Wherein, according to previous in the embodiment of the present invention
Experience PH level threshold values 4.4~4.7, soluble solid content level threshold value 7.9%~8.1%, polyoses content level threshold value
480mg/100ml~530mg/100ml.
Step S2, interval preset time monitors the physical and chemical parameter of the liquid preparation of multiple monitoring points；The liquid system of the present invention
Agent is the syrup class of water-soluble inorganic salt, water soluble organic salt and low viscosity.For different liquid preparation physical and chemical parameters
Difference, usual physical and chemical parameter include in relative density, pH value, soluble solid content, polyoses content, viscosity and run time
It is one or more.
When liquid preparation is the syrup class of low viscosity, physical and chemical parameter includes that pH value, soluble solid content, polysaccharide contain
Amount and run time, for judging that liquid preparation uniforms, run time is used for pH value, soluble solid content, polyoses content
In the run time of judgement equipment.In view of the stability of current on-line monitoring technique, PH can realize on-line monitoring, soluble solid
Object and polyoses content use offline periodic monitor.
It is more ripe in PH on-line monitoring equipment and the current industry of software, 3250 model of plum Teller may be selected, it can be achieved that in real time
It monitors and automatically records；Soluble solid uses offline sampling monitoring, and detection is primary per hour, and Rudolph refractive powers may be selected
Instrument, later stage can gradually extend the assay intervals time according to the stable case of technique；Polyoses content is monitored using offline chemical method, often
Hour detection is primary, permanganimetric method may be selected, when the later stage can gradually extend assay intervals according to the stable case of technique
Between.
When due to above-mentioned 200 continuous production of mixing apparatus, which can be in strip state for a long time, because
This, needs the temporary time limit for carrying out liquid preparation to be verified.On the one hand the temporary time limit once connects for characterizing mixing apparatus 200
The maximum duration of reforwarding row, that is, run time is no more than temporary storage time；On the other hand, following production batch is limited to when temporary
Number formulate provide technological basis.The temporary time limit is obtained using challenge experiment and online verification, challenge experiment：Directly from above-mentioned mixing
Grab sample in equipment 200, room temperature storage, the inspection that (do not recycle mixing) under static conditions, until microorganism, material sense organ, managing
Change any abnormal ends of overall merits such as parameter, obtains the longest time limit under the conditions of challenge；Online verification：In above-mentioned mixing apparatus
On-line period inspection in 200, index is with challenging experiment, the longest continuous production time under confirmation normal production conditions, according to choosing
The longest continuous production time that the longest time limit and online verification that war experiment obtains obtain, obtain the temporary time limit of liquid preparation.
Step S3, the corresponding reason in each monitoring point is obtained according to preset time, physical and chemical parameter and the correspondence of monitoring point
Change index, with physical and chemical index whether not in level threshold value for condition, obtaining the first control valve 203 and the second control valve 204 is
Enough has the judgement of conditions for use as a result, when judgement result characterizes the first control valve 203 and the second control valve 204 does not have enabling
When condition, the control signal of the first control valve 203 and the second control valve 204 is opened in output.
In order to improve the mixing quality of liquid preparation, in the embodiment of the present invention, multiple monitoring points can be arranged mixed first
It closes at tank 201, at the second blending tank 202, at communicating pipe 205, at circulation pipe 206, in the embodiment of the present invention, is saved to reach
Monitoring device is monitored using intermediate portions emphasis.Specifically, multiple monitoring points include being located at the first mixing in the embodiment of the present invention
The first monitoring point A at the feed inlet of tank 201, the second monitoring point B at communicating pipe 205, positioned at the second blending tank 202
The third monitoring point C of discharge outlet and the 4th monitoring point D at circulation pipe 206.According to liquid in entire mixing apparatus 200
The flow direction of body preparation, above-mentioned 4 monitoring points are located at " after in preceding " three of 200 liquid preparation of entire mixing apparatus flow direction
A stage, the fluctuation situation of physical and chemical parameter can reflect the uniform situation of the liquid preparation in entire mixing apparatus 200, dynamic
Under the conditions of each monitoring point physical and chemical index in standard limits, illustrate that all liq preparation reaches uniform in mixing apparatus 200
Change and requires.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (10)
1. a kind of liquid preparation continuous-blending equipment, which is characterized in that including：
First blending tank, for holding simultaneously mixing liquid preparation；
The bottom of second blending tank, second blending tank is connected to by communicating pipe with the bottom of first blending tank；
First control valve is arranged between the feed inlet and liquid mixing system of first blending tank, is matched through liquid mixing system with control
Liquid preparation after system is exported to first blending tank；
Second control valve is arranged between the discharge port and bulking system of the second blending tank liquid, to control the liquid after mixing
Body preparation is exported to the bulking system；
Sampling monitoring device, the physical and chemical parameter for monitoring the liquid preparation of multiple monitoring points for being spaced preset time；
Controller obtains the corresponding reason in each monitoring point according to the preset time, physical and chemical parameter and the correspondence of monitoring point
Change index, according to the physical and chemical index and level threshold value, outputs control signals to the control terminal of the first control control valve and described
The control terminal of second control valve, to control the keying of first control valve and second control valve.
2. liquid preparation continuous-blending equipment as described in claim 1, which is characterized in that the middle part of second blending tank is logical
It crosses circulation pipe to be connected to the middle part of first blending tank, circulating pump is provided at the circulation pipe.
3. liquid preparation continuous-blending equipment as claimed in claim 2, which is characterized in that described in the first blending tank setting
The position of circulation pipe is located at the 2/3 of first blending tank；The position that the circulation pipe is arranged in second blending tank is located at
At the 2/3 of second blending tank.
4. liquid preparation continuous-blending equipment as claimed in claim 2, which is characterized in that the inside of first blending tank is set
It is equipped with the first stirring system；Second blending tank is internally provided with the second stirring system.
5. liquid preparation continuous-blending equipment as claimed in claim 4, which is characterized in that the communicating pipe is mixed with described second
The junction for closing tank is higher than the bottom of second stirring system.
6. liquid preparation continuous-blending equipment as claimed in claim 2, which is characterized in that the physical and chemical parameter include pH value,
Soluble solid content, polyoses content and run time.
7. liquid preparation continuous-blending equipment as claimed in claim 6, which is characterized in that the multiple monitoring point includes being located at
The first monitoring point at the feed inlet of first blending tank, is located at described the at the second monitoring point at the communicating pipe
The third monitoring point of the discharge outlet of two blending tanks and the 4th monitoring point at the circulation pipe.
8. a kind of liquid preparation method for continuously mixing, which is characterized in that the method is applied such as any one of claim 1 to 6 institute
The liquid preparation continuous-blending equipment stated, the method includes：
Preset standard threshold value；
Interval preset time monitors the physical and chemical parameter of the liquid preparation of multiple monitoring points；
The corresponding physical and chemical index in each monitoring point is obtained according to the preset time, physical and chemical parameter and the correspondence of monitoring point,
With the physical and chemical index whether not in level threshold value for condition, it is enough to obtain first control valve and second control valve
Has the judgement of conditions for use as a result, when judgement result characterizes first control valve and second control valve does not have enabling
When condition, the control signal of first control valve and second control valve is opened in output.
9. liquid preparation method for continuously mixing as claimed in claim 8, which is characterized in that the physical and chemical parameter include pH value,
Soluble solid content, polyoses content and run time；
The level threshold value include PH level threshold values, soluble solid content level threshold value, polyoses content level threshold value and temporarily
Deposit the time limit；
Wherein, the pH value is on-line monitoring, and the soluble solid content and polyoses content are off-line monitoring.
10. liquid preparation method for continuously mixing as claimed in claim 9, which is characterized in that the pH value uses plum Teller
3250 are monitored on-line；The soluble solid content carries out off-line monitoring using Rudolph refractometers；The polysaccharide contains
Amount carries out off-line monitoring using permanganimetric method；The temporary time limit is obtained using challenge experiment and online verification.
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