CN108785607A - 一种治疗类风湿关节炎的药物及其制备方法 - Google Patents
一种治疗类风湿关节炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗类风湿关节炎的药物及其制备方法,其主要是由当归、独活、乌梢蛇、鸡血藤、地龙、海风藤、淫羊藿、薏苡仁、牛膝、金钱白花蛇、三棱、杜仲、秦艽、伸筋草、青风藤、鹿角胶、生石膏、全蝎、续断、威灵仙、石斛、巴戟天、独活按一定重量配比制备而成,本发明药物具有祛风胜湿、散寒止痛、活血舒筋、补肝肾、壮筋骨的功能,用于治疗类风湿关节炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗类风湿关节炎的药物及其制备方法,属中药领域。
技术背景
类风湿关节炎是一种病因未明的慢性、以炎性滑膜炎为主的***性疾病。其特征是手、足小关节的多关节、对称性、侵袭性关节炎症,经常伴有关节外器官受累及血清类风湿因子阳性,可以导致关节畸形及功能丧失。中医则认为类风湿关节炎与湿热痹阻、寒热错杂、痰瘀互结、肝肾亏损有关。由于西药治疗副作用大,因此人们对有效治疗类风湿关节炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗类风湿关节炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗类风湿关节炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明是选择当归、独活、乌梢蛇、鸡血藤、地龙、海风藤、淫羊藿、薏苡仁、牛膝、金钱白花蛇、三棱、杜仲、秦艽、伸筋草、青风藤、鹿角胶、生石膏、全蝎、续断、威灵仙、石斛、巴戟天、丹参、莪术、白芍、乳香、没药药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗类风湿关节炎。其中选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治***,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。选用乌梢蛇是因为其性味甘,平,归肝经,有祛风活络,镇痉,治风湿痹痛,四肢麻木,抽搐痉挛,皮肤瘙痒,麻风。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,***。选用地龙是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用海风藤是因为其性味辛苦,微温,入心、肾二经,有祛风湿,通经络,理气的功能,治风寒湿痹,关节疼痛,筋脉拘挛,跌打损伤,哮喘,久咳。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选用金钱白花蛇是因为其性味甘、咸,温,有毒,归肝经,有祛风,通络,镇惊,攻毒的功能,治半身不遂,四肢麻木,抽搐痉挛,破伤风,关节酸痛,风湿顽痹,麻风。选用三棱是因为其性味苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用杜仲是因为其性味甘微辛,温,入肝、肾经,有补肝肾,强筋骨,安胎的功能,治腰脊酸疼,足膝痿弱,小便余沥,阴下湿痒,胎漏欲堕,高血压。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用青风藤是因为其性味苦平,有祛风湿,利不便的功能,治风湿痹痛,鹤膝风,水肿,脚气。选用鹿角胶是因为其性味甘咸,温,入肝、肾经,有补血,益精的功能,治肾气不足,虚劳羸瘦,腰痛,阴疽,男子阳痿、滑精,妇女子宫虚冷,崩漏,带下。选用生石膏是因为其有清热泻火, 除烦止渴,收敛生肌的功能。选用全蝎是因为其性味咸辛,平,有毒,入足厥阴经,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风、半身不遂、口眼喎斜,偏头痛,风湿痹痛,破伤风,***结核,风疹疮肿。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用巴戟天是因为其性味辛甘,温,入肝、肾经,有补肾阳,壮筋骨,祛风湿的功能,治阳痿,少腹冷痛,小便不禁,子宫虚冷,风寒湿痹,腰膝酸痛。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,***,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕痞块,瘀血经闭,食积胀痛,跌打肿痛,早期***。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,***,崩漏,带下。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效
当归25-35克、独活15-25克、乌梢蛇10-20克、鸡血藤10-20克、地龙15-20克、海风藤10-20克、淫羊藿10-15克、薏苡仁10-15克、牛膝10-20克、金钱白花蛇5-10克、三棱5-15克、杜仲10-15克、秦艽5-15克、伸筋草10-20克、青风藤10-15克、鹿角胶10-20克、生石膏10-20克、全蝎5-10克、续断10-15克、威灵仙10-20克、石斛5-10克、巴戟天10-15克、丹参5-15克、莪术5-15克、白芍5-10克、乳香5-15克、没药5-15克。
优选为
当归30克、独活20克、乌梢蛇15克、鸡血藤15克、地龙18克、海风藤15克、淫羊藿12克、薏苡仁12克、牛膝15克、金钱白花蛇8克、三棱10克、杜仲12克、秦艽10克、伸筋草15克、青风藤12克、鹿角胶15克、生石膏15克、全蝎8克、续断12克、威灵仙15克、石斛8克、巴戟天12克、丹参10克、莪术10克、白芍8克、乳香10克、没药10克。
本发明药物的制备方法如下
一、备料
1、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
2、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
3、乌梢蛇:取原药材,刷去灰屑,用时去头、鳞,切段;
4、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
5、地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
6、海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
7、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
8、薏苡仁:取原药材,除去残留皮壳、杂质;
9、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
10、金钱白花蛇:取原药材,除去竹签及头,用时切段;
11、三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
12、杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
13、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
14、伸筋草:筛去灰屑,拣净杂质,切成小段;
15、青风藤:秋冬采老藤,切段,晒干;
16、鹿角胶:取原药材,除去杂质,用时捣碎或研粉;
17、生石膏:去净杂石,洗净泥土,打碎成小块;
18、全蝎:清水漂去盐质,晒干,或微火焙用;
19、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
20、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
21、石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜,晒干;
22、巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
23、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
24、莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
25、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
26、乳香:拣去砂子杂质;
27、没药:拣去杂质,打成碎块。
二、制备
1、将所述重量的当归、独活、乌梢蛇、鸡血藤、地龙、海风藤、淫羊藿、薏苡仁、牛膝、金钱白花蛇、三棱、杜仲、秦艽、伸筋草、青风藤、鹿角胶、生石膏、全蝎、续断、威灵仙、石斛、巴戟天、丹参、莪术、白芍、乳香、没药放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中当归补血和血,调经止痛,润燥滑肠,独活有祛风,胜湿,散寒,止痛的功能二者为君药;乌梢蛇祛风活络,镇痉,鸡血藤有活血、舒筋的功能,与地龙、海风藤、淫羊藿、薏苡仁为臣药,八味药共同发挥祛风胜湿、散寒止痛、活血舒筋、补血和血、润燥滑肠、调经止痛的作用,治疗类风湿关节炎效力全面,且以祛风胜湿、散寒止痛、活血舒筋为主,可治本;牛膝有散瘀血,消痈肿,补肝肾,强筋骨的功能与金钱白花蛇、三棱、杜仲、秦艽、伸筋草、青风藤、鹿角胶、生石膏、全蝎、续断、威灵仙、石斛为佐药;巴戟天有补肾阳,壮筋骨,祛风湿的功能与余下诸药为使药,是治标。
本发明药物具有祛风胜湿、散寒止痛、活血舒筋、补肝肾、壮筋骨的功能,用于治疗类风湿关节炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治类风湿关节炎门诊患者共75例。
2、诊断标准
典型症状为:关节疼痛、关节肿胀、弯曲不利、腰骶疼痛、臀部酸痛、肩痛、非对称性关节痛、髋关节痛、晨僵等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,30天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:类风湿关节炎症状消失,恢复正常,随访一年无复发;
好转:患者关节疼痛、关节肿胀、弯曲不利、腰骶疼痛、臀部酸痛、肩痛、非对称性关节痛、髋关节痛、晨僵的现象减轻,类风湿关节炎症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗类风湿关节炎患者75例,结果显效63例,显效率为84%,好转8例,好转率为10.67%,无效4例,总有效率为94.67%。
Claims (3)
1.一种治疗类风湿关节炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
当归25-35克、独活15-25克、乌梢蛇10-20克、鸡血藤10-20克、地龙15-20克、海风藤10-20克、淫羊藿10-15克、薏苡仁10-15克、牛膝10-20克、金钱白花蛇5-10克、三棱5-15克、杜仲10-15克、秦艽5-15克、伸筋草10-20克、青风藤10-15克、鹿角胶10-20克、生石膏10-20克、全蝎5-10克、续断10-15克、威灵仙10-20克、石斛5-10克、巴戟天10-15克、丹参5-15克、莪术5-15克、白芍5-10克、乳香5-15克、没药5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
当归30克、独活20克、乌梢蛇15克、鸡血藤15克、地龙18克、海风藤15克、淫羊藿12克、薏苡仁12克、牛膝15克、金钱白花蛇8克、三棱10克、杜仲12克、秦艽10克、伸筋草15克、青风藤12克、鹿角胶15克、生石膏15克、全蝎8克、续断12克、威灵仙15克、石斛8克、巴戟天12克、丹参10克、莪术10克、白芍8克、乳香10克、没药10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(2)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(3)乌梢蛇:取原药材,刷去灰屑,用时去头、鳞,切段;
(4)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(5)地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
(6)海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
(7)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(8)薏苡仁:取原药材,除去残留皮壳、杂质;
(9)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(10)金钱白花蛇:取原药材,除去竹签及头,用时切段;
(11)三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
(12)杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
(13)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(14)伸筋草:筛去灰屑,拣净杂质,切成小段;
(15)青风藤:秋冬采老藤,切段,晒干;
(16)鹿角胶:取原药材,除去杂质,用时捣碎或研粉;
(17)生石膏:去净杂石,洗净泥土,打碎成小块;
(18)全蝎:清水漂去盐质,晒干,或微火焙用;
(19)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(20)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(21)石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜,晒干;
(22)巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
(23)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(24)莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
(25)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(26)乳香:拣去砂子杂质;
(27)没药:拣去杂质,打成碎块;
(二)制备
(1)将所述重量的当归、独活、乌梢蛇、鸡血藤、地龙、海风藤、淫羊藿、薏苡仁、牛膝、金钱白花蛇、三棱、杜仲、秦艽、伸筋草、青风藤、鹿角胶、生石膏、全蝎、续断、威灵仙、石斛、巴戟天、丹参、莪术、白芍、乳香、没药放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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