CN108785200B - 一种抗菌、祛痘、抗皱的银离子保湿面膜液、面膜及其制备方法 - Google Patents
一种抗菌、祛痘、抗皱的银离子保湿面膜液、面膜及其制备方法 Download PDFInfo
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- CN108785200B CN108785200B CN201810725318.4A CN201810725318A CN108785200B CN 108785200 B CN108785200 B CN 108785200B CN 201810725318 A CN201810725318 A CN 201810725318A CN 108785200 B CN108785200 B CN 108785200B
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Abstract
本发明涉及到日用化学品技术领域,具体涉及到一种抗菌、祛痘、抗皱的银离子保湿面膜液、面膜及其制备方法。一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:苦参和迷迭香提取物0.5~4份、积雪草提取物2~10份、黄芩提取物0.6~3份、芦荟提取物0.5~3份、银离子溶液0.001~0.03份。
Description
技术领域
本发明涉及到日用化学品技术领域,具体涉及到一种抗菌、祛痘、抗皱的银离子保湿面膜液、面膜及其制备方法。
背景技术
面膜是面部皮肤保养或美容品的一种载体,将其涂敷或贴在脸上保持一定时间,当保养或美容品中的有益物质被皮肤吸收,或者皮表面中有害皮肤健康的物质被面膜吸附后,通过洗净或剥离将其去除,达到面部肤质保养或美化目的。目前面膜制品种类及剂型较多,如膏剂、粉剂、霜剂、乳液及以无纺布、蚕丝、生物纤维等材质为依托的撕拉式湿纸巾面膜等。面膜的美容或保养原理就是利用其覆盖在脸部一定时间,是皮肤与外界的空气与污染暂时隔离,提高肌肤温度,皮肤的毛孔扩张,促进汗腺分泌与新陈代谢,使肌肤的含氧量上升,排除表皮细胞新陈代谢产物和累积油脂类物质,同时面膜中的水分及有益成分渗入表皮的角质层,皮肤变得柔软,自然光亮有弹性。一般将面膜分为泥膏型、撕拉型、冻胶型、湿纸巾型四种形式。尤其湿纸巾式面膜纸,使用方便、效果好、易于存放,深受爱美之人喜爱,迅速在美容品市场占有极大份额。由于贮运方便、运输成本低,也深受生产厂家推崇,因此其消费量极大。
诸多面部皮肤疾病中痤疮的发病率较高,又称粉刺、暗疮,中医古代称面疮,是皮肤可常见病、多发病。如果治疗不及时或盲目治疗会导致面部疾病更加严重,延长病程,甚至留下难以根除的疤痕,影响健康和形象,给青少年带来心理阴影。面部有痤疮时,免疫***不能完全抵御细菌侵害,同时皮肤对外界的刺激更为敏感和强烈,现有的研究的误区认为护肤及化妆品对痤疮的愈合有不良影响,因此一般建议面部出现痤疮期间避免使用化妆品,但是其实使用一些以植物提取物为主要原料的护肤品能使面部皮肤保持水分、清爽舒畅、舒缓抗敏、保湿抗皱,同时杀灭皮肤表面有害细菌,加快伤口愈合、软化角质细胞、防止色素沉积,有益于痤疮以及痘痘的消除以及皮肤屏障修复等。
针对上述技术问题,本发明提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液、面膜,其不含刺激性的杀菌防腐成分,通过多种植物提取物的复配能有效杀灭皮肤表面细菌,加快伤口愈合、软化角质细胞、防止色素沉积,对痤疮以及痘痘具有良好的治愈效果以及优异的保湿抗皱效果。本品风味清爽幽香、安全无毒、无刺激性,长期使用无任何毒副作用。
发明内容
为了解决上述技术问题,本发明的第一个方面提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:苦参和迷迭香提取物0.5~4份、积雪草提取物2~10份、黄芩提取物0.6~3份、芦荟提取物0.5~3份、银离子溶液0.001~0.03份。
作为本发明一种优选的技术方案,所述的抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,还含有以下组分:水40~70份、增粘剂0.1~1.6份、甘草酸二钾0.1~2份、高分子保湿剂0.01~3份、丙二醇1~5份、1,3-丁二醇1~3份、苯氧乙醇0.1~1份。
作为本发明一种优选的技术方案,所述的抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水50~65份、苦参和迷迭香提取物1.5~4份、积雪草提取物5~10份、黄芩提取物0.6~2份、芦荟提取物1~3份、增粘剂0.5~1.4份、甘草酸二钾0.5~1.6份、高分子保湿剂0.2~2.4份、丙二醇1~5份、1,3-丁二醇1~3份、苯氧乙醇0.1~0.5份、银离子溶液0.001~0.01份。
作为本发明一种优选的技术方案,所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为5~10:1。
作为本发明一种优选的技术方案,所述的银离子溶液为壳聚糖改性银离子溶液。
作为本发明一种优选的技术方案,所述的增粘剂为黄原胶、卡波姆、聚乙烯醇、明胶、葡糖酸、玉米淀粉、癸基葡聚糖、聚乙烯吡咯烷酮、羟乙基纤维素、乙酸纤维素、乙酸-丁酸纤维、甲基纤维素、羧甲基纤维素钠中的至少一种。
作为本发明一种优选的技术方案,所述的增粘剂为黄原胶和羟乙基纤维素的混合物,其质量比为1~3:1。
作为本发明一种优选的技术方案,所述的高分子保湿剂选自透明质酸钠、吡咯烷酮羧酸钠、聚谷氨酸钠、芦荟多糖、海藻多糖、胶原蛋白中的至少一种。
本发明的第二个部分提供了一种面膜,所述的面膜包括:作为载体的面膜基质,以及所述的抗菌、祛痘、抗皱的银离子保湿面膜液,所述的面膜基质中吸附有所述的抗菌、祛痘、抗皱的银离子保湿面膜液。
作为本发明一种优选的技术方案,所述的面膜基质的材质选自无纺布、蚕丝、概念隐形蚕丝、水凝胶、纯棉纤维、生物纤维、粘胶纤维、天丝纤维、竹炭纤维中的至少一种。
参考以下详细说明更易于理解本申请的上述以及其他特征、方面和优点。
本发明的面膜液性质稳定,在高低温条件下放置透明性、沉淀、气味均不产生变化。本发明的面膜具有优异的补水保湿效果,同时具有修复皮肤屏障,紧致皮肤,促进胶原蛋白的再生等功效,能有效预防皱纹的发生,具有优异的抗皱效果。并且本发明的面膜液对大肠杆菌、金黄色葡萄球菌、白色假丝酵母菌和链球菌还有痤疮丙酸杆菌均有明显的抑菌效果,同时对皮肤无刺激,具有优异的补水、抗皱、止痒、消炎效果。
具体实施方式
参选以下本发明的优选实施方法的详述以及包括的实施例可更容易地理解本发明的内容。除非另有限定,本文使用的所有技术以及科学术语具有与本发明所属领域普通技术人员通常理解的相同的含义。当存在矛盾时,以本说明书中的定义为准。
如本文所用术语“由…制备”与“包含”同义。本文中所用的术语“包含”、“包括”、“具有”、“含有”或其任何其它变形,意在覆盖非排它性的包括。例如,包含所列要素的组合物、步骤、方法、制品或装置不必仅限于那些要素,而是可以包括未明确列出的其它要素或此种组合物、步骤、方法、制品或装置所固有的要素。
连接词“由…组成”排除任何未指出的要素、步骤或组分。如果用于权利要求中,此短语将使权利要求为封闭式,使其不包含除那些描述的材料以外的材料,但与其相关的常规杂质除外。当短语“由…组成”出现在权利要求主体的子句中而不是紧接在主题之后时,其仅限定在该子句中描述的要素;其它要素并不被排除在作为整体的所述权利要求之外。
当量、浓度、或者其它值或参数以范围、优选范围、或一系列上限优选值和下限优选值限定的范围表示时,这应当被理解为具体公开了由任何范围上限或优选值与任何范围下限或优选值的任一配对所形成的所有范围,而不论该范围是否单独公开了。例如,当公开了范围“1至5”时,所描述的范围应被解释为包括范围“1至4”、“1至3”、“1至2”、“1至2和4至5”、“1至3和5”等。当数值范围在本文中被描述时,除非另外说明,否则该范围意图包括其端值和在该范围内的所有整数和分数。
单数形式包括复数讨论对象,除非上下文中另外清楚地指明。“任选的”或者“任意一种”是指其后描述的事项或事件可以发生或不发生,而且该描述包括事件发生的情形和事件不发生的情形。
说明书和权利要求书中的近似用语用来修饰数量,表示本发明并不限定于该具体数量,还包括与该数量接近的可接受的而不会导致相关基本功能的改变的修正的部分。相应的,用“大约”、“约”等修饰一个数值,意为本发明不限于该精确数值。在某些例子中,近似用语可能对应于测量数值的仪器的精度。在本申请说明书和权利要求书中,范围限定可以组合和/或互换,如果没有另外说明这些范围包括其间所含有的所有子范围。
此外,本发明要素或组分前的不定冠词“一种”和“一个”对要素或组分的数量要求(即出现次数)无限制性。因此“一个”或“一种”应被解读为包括一个或至少一个,并且单数形式的要素或组分也包括复数形式,除非所述数量明显旨指单数形式。
“聚合物”意指通过聚合相同或不同类型的单体所制备的聚合化合物。通用术语“聚合物”包含术语“均聚物”、“共聚物”、“三元共聚物”与“共聚体”。
“共聚体”意指通过聚合至少两种不同单体制备的聚合物。通用术语“共聚体”包括术语“共聚物”(其一般用以指由两种不同单体制备的聚合物)与术语“三元共聚物”(其一般用以指由三种不同单体制备的聚合物)。其亦包含通过聚合四或更多种单体而制造的聚合物。“共混物”意指两种或两种以上聚合物通过物理的或化学的方法共同混合而形成的聚合物。
为了解决上述技术问题,本发明的第一个方面提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:苦参和迷迭香提取物0.5~4份、积雪草提取物2~10份、黄芩提取物0.6~3份、芦荟提取物0.5~3份、银离子溶液0.001~0.03份。
作为本发明一种优选的技术方案,所述的抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,还含有以下组分:水40~70份、增粘剂0.1~1.6份、甘草酸二钾0.1~2份、高分子保湿剂0.01~3份、丙二醇1~5份、1,3-丁二醇1~3份、苯氧乙醇0.1~1份。
作为本发明一种优选的技术方案,所述的抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水50~65份、苦参和迷迭香提取物1.5~4份、积雪草提取物5~10份、黄芩提取物0.6~2份、芦荟提取物1~3份、增粘剂0.5~1.4份、甘草酸二钾0.5~1.6份、高分子保湿剂0.2~2.4份、丙二醇1~5份、1,3-丁二醇1~3份、苯氧乙醇0.1~0.5份、银离子溶液0.001~0.01份。
苦参
苦参为豆科植物苦参Sophora flavescens Ait.的干燥根。性味苦,寒。归经归心、肝、胃、大肠、膀胱经。功能主治清热燥湿,杀虫,利尿。用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风;外治滴虫性***炎。
根中含生物碱:苦参碱(matrine)、氧化苦参碱(oxymatrine)、N-氧化槐根碱(N-oxysophocarpine)、槐定碱(sophoridine)、右旋别苦参碱(-allomatrine)、右旋异苦参碱(I-somatrine)、右旋槐花醇(sophoranol)、(+)槐花醇N-氧化物(sophoranol N-oxide)、左旋槐根碱(sophocarpine)、左旋槐胺碱(sophoramine)、右旋-N-甲基金雀花碱(N-methylcytisine)、左旋臭豆碱(anagyrine)、赝靛叶碱(baptifoline)。根中还含多种黄酮类化合物:苦参新醇(kushenol)A、B、C、D、E、F、G、H、I、J、K、L、M、N、O,苦参查耳酮(kuraridin),苦参查耳酮醇(kuraridinol),苦参醇(kurarinol),新苦参醇(neokurarinol),降苦参醇(norkurarinol),异苦参酮(isokurarinone),刺芒柄花素(for-mononetin),苦参酮(kurarinone),降苦参酮(norkurarinone),甲基苦参新醇C(methylkushenol C),l-山槐素(lmaackiain),三叶豆紫檀甙(trifolirhizin)及三叶豆紫檀甙丙二酸酯(rtifolirhizin-6”-O-malonate),苦参素(kushenin),异脱水淫羊藿素(isoanhy-droicaritin),降脱水淫羊藿素(noranhydroicaritin),黄腐醇(xan-thohumol),异黄腐酸(isoxanthohumol),木犀草素-7-葡萄糖甙(luteolin-7-glucoside)。此外,根中还含有三萜皂甙:苦参皂甙(sophoraflavoside)Ⅰ,Ⅱ、Ⅲ、Ⅳ,大豆皂甙(soyasaponin)I以及醌类化合物:苦参醌(kushequinone)A。
苦参碱具有抗癌活性。苦参碱还能通过兴奋β受体,尤其是兴奋中枢的β受体,解除支气管痉挛及抑制抗体和慢反应物质的释放而产生平喘作用的。苦参总碱单独使用有轻度的镇痛以及安定作用。苦参碱可降低过敏介质的释放,为免疫抑制剂。
迷迭香
迷迭香为唇形科植物迷迭香的全草。全草含橙皮甙(hesperidin)、香叶木甙(dios-min)、滨蓟黄甙(cirsimarin)、结合卵果蕨甙(phegopolin)、楔叶泽兰素-3-O-葡萄糖甙(eupafolin-3-O-glucoside)、楔叶泽兰素-4-O-葡萄糖甙(eupafolin-4-O-glucoside)、高车前甙(homoplantagi-nin)、尼泊尔黄酮甙(nepetrin)、芹菜素-7-葡萄糖甙(apigetrin)、木犀草素-3-O-葡萄糖醛酸甙(luteolin-3-O-glucuronide)、木犀草素-7-葡萄糖甙(luteolin-7-glucoside)、5-羟基-4,7-二甲氧基黄酮(5-hydroxy-4,7-dimethoxyflavone)、4,5-二羟-7-甲氧基黄酮(4,5-dihydroxy-7-methoxyflavone)、鼠尾草苦内酯(carnosol)、迷迭香碱(rosmaricine)、异迷迭香碱(isorosmaricine)、表-α-香树脂醇(epi-α-amyrin)、α-香树脂醇(α-amyrin)、β-香树脂醇(β-amyrin)、白桦脂醇(betulin)、β-谷甾醇(β-sitosterol)、芫花素(genkwanin)、7-乙氧基迷迭香酚(7-ethoxyrosmanol)、迷迭香酚(rosmanol)、7-甲氧基迷迭香酚(7-methoxyrosmanol)、熊果酸(ursolic acid)、19α-羟基熊果酸(19α-hydroxyursolic acid)、2β-羟基齐墩果酸(2β-hydroxyoleanolic acid)、白桦脂酸(betulinic acid)、迷迭香酸(rosmarinic acid)、鼠尾草酸(carnosic acid)。此外尚含唇形草鞣质酸(labiatic acid)。根含紫杉双醌(tarodione)、7α-羟基总状土木香醌(7α-hy-droxyroyleanone)、陷丹参酮(cryptotanshinone)。枝、叶中含有抗菌作用的挥发油,其中含α-蒎烯(α-pinene)、樟烯(camphene)、1,8-桉叶素(cineole)、龙脑(borneol)、樟脑(camphor)、α-和β-松油醇(terpineol)、松油烯-4-醇(terpien-4-ol)、马鞭烯醇(verbenol)、乙酸龙脑酯(bornylac-etate)等。
迷迭香味辛;性温。功能主治:发汗;健脾;安神;止痛,包括各种头痛;防止早期脱发等。迷迭香叶的挥发油对金黄色萄萄球菌、大肠杆菌、霍乱弧菌等有肯定的抗菌作用。迷迭香碱还能加强大脑皮层的抑制过程,有催眠、抗惊厥作用。迷迭香中所含香叶木甙能降低毛细血管渗透性,对毛细血管脆性增加的治疗效果比芦丁好,并且毒性低。
天然植物迷迭香不仅是一种香料植物,而且还可从中提取抗氧化剂、迷迭香精油和医药中间体,是目前公认的最具有抗氧化作用的植物之一。它的抗氧化成分主要为鼠尾草酸、鼠尾草酚、迷迭香酚、熊果酸、迷迭香酸等成分,这些成分具有延缓衰老、防腐、抗菌、抗氧化等功效,广泛用于食品、化妆品和医药保健领域。除此之外由于迷迭香优异的抗氧化、抗自由基能力,因而其还具有收敛以及皮肤修复效果。迷迭香提取物不仅能够有效刺激皮肤血液循环,并且与皮肤有很强的亲和性,使得有效成分能够被皮肤吸收。
作为本发明一种优选的技术方案,所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为5~10:1。
作为本发明一种优选的技术方案,所述的苦参和迷迭香提取物的制备方法,至少包括以下步骤:
按重量份,取干燥的苦参根和迷迭香干叶,粉碎后过40目筛,将其混合均匀,投入反应釜中,加入乙醇,苦参根和迷迭香干叶的总质量与乙醇的质量之比为1:3~5,在70~80℃下回流提取,每次提取时间为0.3~2h,共提取两次,合并提取液;向提取液中加入活性炭,活性炭与提取液的质量比为2~7:100,搅拌30min,过500目滤布,减压浓缩至干,得到所述的苦参和迷迭香提取物。
本发明人发现将苦参和迷迭香进行混合提取不仅可以促进有效物质的溶出,并且有效改善了苦参提取物的易氧化性和易吸湿性、迷迭香提取物在水中的低溶解性,同时苦参和迷迭香提取物在抗炎、抗菌、皮肤修护等中均表现出了良好的协同作用。
积雪草
积雪草为伞形科植物积雪草Centella asiatica(L.)Urb.的干燥全草。夏、秋二季采收,除去泥沙,晒干。性味苦、辛,寒,归肝、脾、肾经。功能主治清热利湿,解毒消肿。用于湿热黄疸,中暑腹泻,砂淋血淋,痈肿疮毒,跌扑损伤。
积雪草中含多种α-香树脂醇型的三萜成分,其中有积雪草甙(Asiaticoside)、参枯尼甙(Thankuniside)、异参枯尼甙(Isothankuniside)、羟基积雪草甙(Madecas-soside)、玻热模甙(Brahmoside)、破热米甙(Brah-minoside)和破热米酸(Brahmic acid),以及马达积雪草酸(Madasiatic acid)等。此外,尚含内消旋肌醇(Meso-inositol)、积雪草糖(Centellose,一种寡糖)、蜡、胡萝卜烃类(Carotenoids)、叶绿素,以及山奈酚、槲皮素和葡萄糖、鼠李糖的黄酮甙。全草主要含三萜酸和三萜皂甙。三萜有积雪草酸(siatic acid)、羟基积雪草酸(brahmic acid)、异羟基积雪草酸(isobrahmic acid)及桦皮酸(be-tulinicacid)等。三萜皂甙有积雪草甙(asiaticoside,madecassol)、羟基积雪草甙(madecassoside)、落得打三糖甙(brahmoside)及落得打四糖甙(brahminoside),又谓含参枯甙(thankuniside)及异参枯甙(isothankuniside)。另含山奈素和槲皮素及其甙、积雪草碱(hydrocotyline)、内消旋肌醇(inositol)、积雪草低聚糖(centellose)、谷甾醇、维生素C、胡萝卜素、绿色挥发油及树脂状物质。
积雪草中所含的甙具有镇静、安定作用;其水提物还具有抗菌作用。积雪草的醇提物无镇痛作用,积雪草甙能治疗皮肤溃疡,如顽固性创伤、皮肤结核、麻风等。积雪草可以紧致表皮与真皮连接部分,能使皮肤柔软,有助于解决皮肤松弛现象(尤其针对产后妈妈);帮助促进真皮层中胶原蛋白形成,使纤维蛋白再生;既能促进表皮与真皮之间的密切连接,又能抑制脂肪细胞的增加,防止皮肤水肿、出现肥胖。
作为本发明一种优选的技术方案,所述的积雪草提取物通过渗漉法制备得到,所述的提取溶剂为体积百分比浓度为30~70%的乙醇水溶液。
作为本发明一种优选的技术方案,所述的积雪草提取物的制备方法,至少包括以下步骤:
取干燥的积雪草全草粉碎至颗粒度为5~60目,将其装填入渗漉柱内,压实测得积雪草堆积体积,加入0.6~1倍积雪草堆积体积的提取溶剂,在30~70℃浸泡0.2~1h;将1~3倍积雪草堆积体积的提取溶剂自上而下流经渗漉柱进行渗漉提取,提取溶剂流速为0.2~1倍积雪草堆积体积/小时,渗漉提取的温度为30~70℃,收集渗漉液,减压浓缩回收溶剂得到积雪草提取物;所述的提取溶剂为体积百分比浓度为30~70%的乙醇水溶液。
黄芩
黄芩为唇形科植物黄芩Scutellaria baicalensis Georgi的干燥根。性味苦,寒。归肺、胆、脾、大肠、小肠经。功能主治:清热燥湿,泻火解毒,止血,安胎。用于湿温、暑温胸闷呕恶,湿热痞满,泻痢,黄疸,肺热咳嗽,高热烦渴,血热吐衄,痈肿疮毒,胎动不安。
黄芩含黄酮类化合物:黄芩素(baicalein)、黄芩新素(neobaicalein)即黄芩黄酮Ⅱ(skullcapflavoneⅡ)、黄芩甙(baicalin)、汉黄芩素(wogonin)、汉黄芩甙(wogono-side)、木蝴蝶素A(oroxylin,oroxylin A)、7-甲氧基黄芩素(7-methoxbaic alein)、黄芩黄酮(skullcapflavone)Ⅰ、二氢木蝴蝶素A(dihydrooroxylin A)、白杨素(chrysin)、2,5,8-三羟基-7-甲氧基黄酮(2,5,8-trihydroxy-7-methoxy-flavone)、2,5,8-三羟基-6,7-二甲氧基黄酮(2,5,8-trihydroxy-6,7-dimethoxyflavone)、4,5,7-三羟基-6-甲氧基黄烷酮(4,5,7-trhydroxy-6-methoxyflavanone)、2,3,5,6,7-五羟基黄烷酮(2,3,5,6,7-pentahydroxyflavanone)、汉黄芩素-5-β-D-葡萄糖甙(wogonin-5-β-D-glucoside)、2-(3-羟基-4-甲氧基苯基)-乙基-1-O-α-L-鼠李糖基([2-(3-hydroxy-4-methoxyphenyl)ethyl-1-O-α-L-rhamnosyl)、(1→3)-β-D(4-阿魏酰基)-葡萄糖((1→3)-β-D-(4-feruloyl)-glucoside)、白杨素-6-C-α-L-***糖甙(chrysin-6-C-β-D-glucoside-8-C-β-L-arabinoside)、白杨素-6-C-α-L-***糖甙-8-C-β-D-葡萄糖甙(chrysin-6-C-α-L-arabi-noside-8-C-β-D-glucoside)、(2S)-2,5,6,7-四羟基黄烷酮[(2S)-2,5,6,7-terahydroxyflavanone]、5,7,2,6-四羟基黄酮(5,7,2,7-tetrahydroxyflavone)、5,8-二羟基-6,7-二甲氧基黄酮(5,8-dihydroxy-6,7-drimethoxyflavone)、5,7,4-三羟基-8-甲氧基黄酮(5,7,4-trihydroxy-8-methoxyflavone)、木蝴蝶素A-7-O-葡萄糖醛酸甙(oroxylinA-7-O-glucuronide)、5,7,2-三羟基甲氧基黄酮(5,7,2-trihyroxy-6-methoxyflavone)、5,2-二羟基-6,7,8-三甲氧基黄酮(5,2-dihydroxy-6,7,8-trimethoxyfla-vone)、5-羟基-7,8-二甲氧基黄酮(5-hydroxy-7,8-dimethoxy-flavone)、去甲汉黄芩素(norwogonin)、二氢黄芩素(dihydro-baicalin)、5,7,2-三羟基黄酮(5,7,2-trihydroxyflavone)、5,7,2-三羟基-8,6-二甲氧基黄酮(5,7,2-trihydroxy-8,6-dimethoxyflavone)、5,7,2,5-四羟基-8,6-二甲氧基黄酮即粘毛黄芩素Ⅲ(5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone,vis-ciduiinⅢ)、5,2,5-三羟基三甲氧基黄酮(5,2,5-trihy-droxy-6,7,8-trimethoxyflavone)、黄芩素-7-O-β-D-吡喃葡萄糖甙(baicalein-7-O-β-D-glucopyranoside)、5,7,2-三羟基-8-甲氧基黄酮(5,7,2-trhiyroxy-8-methoxyflavone)、5,2,6-三羟基-7,8-二甲氧基黄酮、5,2,6-三羟基-6-甲氧基黄酮(5,7,2-trihydroxy-6-methoxyflavone)、5,7,2,3-四羟基黄酮(5,7,2,3-trihydroxy-6-methoxyflavone)、5,7,2,3-四羟基黄酮(5,7,2,3-tetrahydroxyflavone)、3,5,7,2,5,6-五羟基黄酮(3,5,7,2,6-pentahydroxyflavone)即粘毛黄芩素Ⅰ(viscidulinⅠ)、(2S)-7,2,6-三羟基-5-甲氧基黄烷酮[(2S)-7,2,6-trihydroxy-5-methoxyflavanone]、2,6,2,4-四羟基-6-甲氧基查尔酮(2,6,2,4-tetrahydroxy-6-methoxychalcone)、5,7,2,5-四羟基黄酮(5,7,2,5-tetrahydroxyflavone)、左旋圣草素(eriodictyol)、半枝莲种素(rivularin)及粘毛黄芩素Ⅲ-2-O-β-D-吡喃葡萄糖甙(viscidulinⅢ-2-O-β-D-glucoplyranoside)等。另外还含β-谷甾醇(β-sitosterol)、菜油甾醇(campesterol)及豆甾醇(stigmasterol)。
黄芩中的黄酮类物质具有抗菌消炎、解热、镇痛、抗氧化和清除自由基等功效,同时对紫外线吸收能力强。提取物黄芩素和黄芩苷可减少自由基的生成或有效地消除已生成的自由基,并能有效延缓皮肤衰老和皱纹的产生。医学界认为黄芩是理想的无毒、无害和效果优良的天然防晒物质。黄芩提取物对荧光素酶的活化和对干扰素分泌的促进,这说明其对抑制皮炎,增加皮肤抵抗力有作用。黄芩提取物有中和组胺的能力,所以能防治过敏。
作为本发明一种优选的技术方案,所述的黄芩提取物的制备方法,至少包括以下步骤:
取黄芩,粉碎过100目筛,加入7~10倍质量的水,在0~10℃和pH=5~7的条件下搅拌、超声(频率为40kHz,功率为100W)提取两次,每次15~40min,合并提取液,过滤,使用苹果酸将滤液的pH调至4~6,加热至50~60℃并保温10~15h,过滤收集沉淀,水洗、干燥,得到所述的黄芩提取物。
芦荟
芦荟为百合科植物库拉索芦荟Aloe barbadensis Miller,它是目前应用在食品、药品和美容方面最广泛的品种。芦荟的主要成分有:(1)稳定化芦荟凝胶成份:木质素、芦荟酸、皂素、蒽醌、芦荟素、肉桂酸醌、芦荟苷大、芦荟大黄素、酚、大黄根酸、蒽等;(2)维生素:维生素B1、叶酸、维生素B2、维生素C、烟酰胺、维生素E、维生素B6、维生素A、胆碱;(3)单糖和粘多糖:纤维素、葡萄糖、L-鼠李糖、苷露糖、木糖等;(4)酶:氧化酶、脂酶、淀粉酶、过氧化氢酶:(5)必需氨基酸:赖氨酸、亮氨酸、苏氨酸、异亮氨酸、苯丙氨酸、缬氨酸等。科学研究发现芦荟中不少成分对人体皮肤有良好的营养滋润作用,且刺激性小,有增白皮肤、防止皮肤上的色素形成及浸润、软化皮肤的作用,同时还有止痛消痒、抑汗防臭、防粉刺、防老年斑,对皮肤粗糙、面部皱纹等有一定疗效。滋润美容作用:芦荟多糖和维生素对皮肤有良好的营养、滋润、增白作用。芦荟大黄素等属蒽醌甙物质能使头发柔软而有光泽,且具有去头屑的作用。抗衰老作用:芦荟中的粘液(即蛋白质)是防止细胞老化和治疗慢性过敏的重要成分。防晒作用:芦荟中的天然蒽醌甙或蒽的衍生物,能吸收紫外线,防止皮肤红、褐斑产生。
作为本发明一种优选的技术方案,所述的芦荟提取物的制备方法,至少包括以下步骤:
割取一定量的新鲜芦荟叶片,用刀削去外皮,切块,放到榨汁机里榨取汁液,用四层纱布过滤,滤渣弃掉,滤液置冰箱(3~6℃)中保存10h,然后再用四层纱布过滤,弃去渣,得到所述的芦荟提取物。
作为本发明一种优选的技术方案,所述的银离子溶液为壳聚糖改性银离子溶液。
作为本发明一种优选的技术方案,所述的银离子溶液的制备方法,至少包括以下步骤:
按重量比为1:1:1:1取干燥的中国红玫瑰、槐花、丁香、薰衣草,粉碎并混合均匀,向其中加入5~8倍质量的体积百分比浓度为15~25%的乙醇水溶液,40~60℃提取5~10h,过滤,减压浓缩至无乙醇,得到植物提取物;
取壳聚糖,将其溶于体积分数为2%的醋酸水溶液,配置质量浓度为2%的壳聚糖醋酸水溶液,搅拌至壳聚糖完全溶解;取壳聚糖醋酸溶液,加入浓度为12.5mmol/L的AgNO3水溶液,壳聚糖醋酸溶液和AgNO3水溶液的体积比为20~30:1,搅拌20~45min;逐滴加入所述植物提取物,所述植物提取物和AgNO3水溶液的体积比为20~50:1,搅拌,24~40min后得到所述的银离子溶液。
本发明人发现壳聚糖改性银离子溶液相对于普通银离子,其抗菌性明显增强,并通过与其他植物提取物的复配,有效降低了常用防腐抗菌剂的用量,增强了所述的面膜液的安全性。另外,本发明的银离子溶液通过特殊的合成方法制备得到,其分散性好,不聚沉,所述的面膜液具有优异的稳定性。本发明的银离子溶液中银被包覆在壳聚糖内部,不直接与皮肤接触,降低了其对皮肤的刺激性,并且通过壳聚糖改性,银与面膜基质的相互作用增强,使用者在使用面膜的过程中银能发挥其抗菌以及促进细胞生长、伤口愈合等功效,同时无刺激、低致敏,几乎无残留。
作为本发明一种优选的技术方案,所述的增粘剂为黄原胶、卡波姆、聚乙烯醇、明胶、葡糖酸、玉米淀粉、癸基葡聚糖、聚乙烯吡咯烷酮、羟乙基纤维素、乙酸纤维素、乙酸-丁酸纤维、甲基纤维素、羧甲基纤维素钠中的至少一种。
作为本发明一种优选的技术方案,所述的增粘剂为黄原胶和羟乙基纤维素的混合物,其质量比为1~3:1。
作为本发明一种优选的技术方案,所述的高分子保湿剂选自透明质酸钠、吡咯烷酮羧酸钠、聚谷氨酸钠、芦荟多糖、海藻多糖、胶原蛋白中的至少一种。
本发明的第二个方面提供了所述的抗菌、祛痘、抗皱的银离子保湿面膜液的制备方法,至少包括以下步骤:
按重量份,将水加入反应釜中,加热至75~85℃,以10~20r/min的速度搅拌,向其中加入增粘剂、甘草酸二钾、高分子保湿剂、丙二醇、1,3-丁二醇、苯氧乙醇,搅拌至物料完全溶解,保持10~20r/min的速度搅拌并降温,冷却至35~45℃,向其中加入苦参和迷迭香提取物、积雪草提取物、黄芩提取物、芦荟提取物、银离子溶液,保持10~20r/min的搅拌速度至混合均匀,加入pH调节剂,调节pH为6~7,冷却至25~34℃,继续搅拌15~30min,得到所述的抗菌、祛痘、抗皱的银离子保湿面膜液。
作为本发明一种优选的技术方案,所述的pH调节剂选自乳酸钙、焦磷酸、羟乙基氨基丁酸、辛酰水杨酸、癸二酸二乙酯、苹果酸二辛酯、双丙苷醇水杨酸酯、叶酸、三乙醇胺、柠檬酸、酒石酸、苹果酸、二乙醇胺、乙二胺四乙酸、富马酸、磷酸中的至少一种。
本发明的第三个方面提供了一种面膜,所述的面膜包括:作为载体的面膜基质,以及所述的抗菌、祛痘、抗皱的银离子保湿面膜液,所述的面膜基质中吸附有所述的面膜液。
作为本发明一种优选的技术方案,所述的面膜基质的材质选自无纺布、蚕丝、概念隐形蚕丝、水凝胶、纯棉纤维、生物纤维、粘胶纤维、天丝纤维、竹炭纤维中的至少一种。
本发明的面膜液不含刺激性的杀菌防腐成分,通过多种植物提取物与银离子的复配能有效杀灭皮肤表面细菌,加快伤口愈合、软化角质细胞、防止色素沉积,对痤疮以及痘痘具有良好的治愈效果。长期使用本发明的面膜液对面膜皮肤具有清除污物、美化面部皮肤、消炎抗菌、减轻痤疮、淡化青春痘疤痕等作用,同时可以使面部皮肤平滑、细致、有光泽,能有效预防皱纹的形成。本发明不含香精、色素、防腐剂,适合各阶层、各年龄段人群对面部保养护理的需要,特别是面部有痤疮(青春痘)的皮肤患者。本品风味清爽幽香、安全无毒、无刺激性,长期使用无任何毒副作用。
下面通过实施例对本发明进行具体描述。有必要在此指出的是,以下实施例只用于对本发明作进一步说明,不能理解为对本发明保护范围的限制,该领域的专业技术人员根据上述本发明的内容做出的一些非本质的改进和调整,仍属于本发明的保护范围。
另外,如果没有其它说明,所用原料都是市售的。
实施例1:
实施例1提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水40份、苦参和迷迭香提取物0.5份、积雪草提取物2份、黄芩提取物0.6份、芦荟提取物0.5份、增粘剂0.1份、甘草酸二钾0.1份、高分子保湿剂0.01份、丙二醇1份、1,3-丁二醇1份、苯氧乙醇0.1份、银离子溶液0.001份。
所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为5:1。
所述的苦参和迷迭香提取物的制备方法,至少包括以下步骤:
按重量份,取干燥的苦参根和迷迭香干叶,粉碎后过40目筛,将其混合均匀,投入反应釜中,加入乙醇,苦参根和迷迭香干叶的总质量与乙醇的质量之比为1:5,在70~80℃下回流提取,每次提取时间为1.5h,共提取两次,合并提取液;向提取液中加入活性炭,活性炭与提取液的质量比为5:100,搅拌30min,过500目滤布,减压浓缩至干,得到所述的苦参和迷迭香提取物。
所述的积雪草提取物通过渗漉法制备得到,所述的提取溶剂为体积百分比浓度为70%的乙醇水溶液。
所述的积雪草提取物的制备方法,至少包括以下步骤:
取干燥的积雪草全草粉碎至颗粒度为40目,将其装填入渗漉柱内,压实测得积雪草堆积体积,加入0.8倍积雪草堆积体积的提取溶剂,在50℃浸泡1h;将2倍积雪草堆积体积的提取溶剂自上而下流经渗漉柱进行渗漉提取,提取溶剂流速为0.5倍积雪草堆积体积/小时,渗漉提取的温度为50℃,收集渗漉液,减压浓缩回收溶剂得到积雪草提取物;所述的提取溶剂为体积百分比浓度为70%的乙醇水溶液。
所述的黄芩提取物的制备方法,至少包括以下步骤:
取黄芩,粉碎过100目筛,加入8倍质量的水,在5℃和pH=5的条件下搅拌、超声(频率为40kHz,功率为100W)提取两次,每次30min,合并提取液,过滤,使用苹果酸将滤液的pH调至5,加热至50℃并保温12h,过滤收集沉淀,水洗、干燥,得到所述的黄芩提取物。
所述的芦荟提取物的制备方法,至少包括以下步骤:
割取一定量的新鲜芦荟叶片,用刀削去外皮,切块,放到榨汁机里榨取汁液,用四层纱布过滤,滤渣弃掉,滤液置冰箱(3~6℃)中保存10h,然后再用四层纱布过滤,弃去渣,得到所述的芦荟提取物。
所述的增粘剂为黄原胶,为购自西安泽隆生物技术有限公司的化妆品级产品。所述的高分子保湿剂选自透明质酸钠,为购自西安泽隆生物技术有限公司的化妆品级产品。
所述的银离子溶液为壳聚糖改性银离子溶液。
所述的银离子溶液的制备方法,至少包括以下步骤:
按重量比为1:1:1:1取干燥的中国红玫瑰、槐花、丁香、薰衣草,粉碎并混合均匀,向其中加入8倍质量的体积百分比浓度为18%的乙醇水溶液,55℃提取7h,过滤,减压浓缩至无乙醇,得到植物提取物;
取壳聚糖,将其溶于体积分数为2%的醋酸水溶液,配置质量浓度为2%的壳聚糖醋酸水溶液,搅拌至壳聚糖完全溶解;取壳聚糖醋酸溶液,加入浓度为12.5mmol/L的AgNO3水溶液,壳聚糖醋酸溶液和AgNO3水溶液的体积比为25:1,搅拌25min;逐滴加入所述植物提取物,所述植物提取物和AgNO3水溶液的体积比为40:1,搅拌,30min后得到所述的银离子溶液。
所述的抗菌、祛痘、抗皱的银离子保湿面膜液的制备方法,至少包括以下步骤:
按重量份,将水加入反应釜中,加热至75~85℃,以10~20r/min的速度搅拌,向其中加入增粘剂、甘草酸二钾、高分子保湿剂、丙二醇、1,3-丁二醇、苯氧乙醇,搅拌至物料完全溶解,保持10~20r/min的速度搅拌并降温,冷却至35~45℃,向其中加入苦参和迷迭香提取物、积雪草提取物、黄芩提取物、芦荟提取物、银离子溶液,保持10~20r/min的搅拌速度至混合均匀,加入pH调节剂,调节pH为6~7,冷却至25~34℃,继续搅拌15~30min,得到所述的抗菌、祛痘、抗皱的银离子保湿面膜液。所述的pH调节剂为苹果酸或三乙醇胺。
实施例2:
实施例2提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水70份、苦参和迷迭香提取物4份、积雪草提取物10份、黄芩提取物3份、芦荟提取物3份、增粘剂1.6份、甘草酸二钾2份、高分子保湿剂3份、丙二醇5份、1,3-丁二醇3份、苯氧乙醇1份、银离子溶液0.03份。
所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为10:1。
所述的苦参和迷迭香提取物的制备方法同实施例1。
所述的积雪草提取物通过渗漉法制备得到,所述的提取溶剂为体积百分比浓度为30%的乙醇水溶液。
所述的积雪草提取物的制备方法同实施例1。
所述的黄芩提取物的制备方法同实施例1。
所述的芦荟提取物的制备方法同实施例1。
所述的增粘剂为卡波姆,为购自广州南嘉化工科技有限公司的卡波姆940。所述的高分子保湿剂选自吡咯烷酮羧酸钠,购自汕头市勋诺化工科技有限公司。
所述的银离子溶液为壳聚糖改性银离子溶液。
所述的银离子溶液的制备方法同实施例1。
所述的抗菌、祛痘、抗皱的银离子保湿面膜液的制备方法同实施例1。所述的pH调节剂为苹果酸或三乙醇胺。
实施例3:
实施例3提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水50份、苦参和迷迭香提取物1.5份、积雪草提取物5份、黄芩提取物0.6份、芦荟提取物1份、增粘剂0.5份、甘草酸二钾0.5份、高分子保湿剂0.2份、丙二醇1份、1,3-丁二醇1份、苯氧乙醇0.1份、银离子溶液0.001份。
所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为8:1。
所述的苦参和迷迭香提取物的制备方法同实施例1。
所述的积雪草提取物通过渗漉法制备得到,所述的提取溶剂为体积百分比浓度为30%的乙醇水溶液。
所述的积雪草提取物的制备方法同实施例1。
所述的黄芩提取物的制备方法同实施例1。
所述的芦荟提取物的制备方法同实施例1。
所述的增粘剂为黄原胶和羟乙基纤维素的混合物,其质量比为1:1。所述的黄原胶为购自西安泽隆生物技术有限公司的化妆品级产品。羟乙基纤维素,CAS:0255-10-7,购自广州博峰化工科技有限公司。所述的高分子保湿剂选自聚谷氨酸钠,购自陕西承乾生物科技有限公司,型号为CQ25513-46-6。
所述的银离子溶液为壳聚糖改性银离子溶液。
所述的银离子溶液的制备方法同实施例1。
所述的抗菌、祛痘、抗皱的银离子保湿面膜液的制备方法同实施例1。所述的pH调节剂为苹果酸或三乙醇胺。
实施例4:
实施例4提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水65份、苦参和迷迭香提取物4份、积雪草提取物10份、黄芩提取物2份、芦荟提取物3份、增粘剂1.4份、甘草酸二钾01.6份、高分子保湿剂2.4份、丙二醇5份、1,3-丁二醇3份、苯氧乙醇0.5份、银离子溶液0.01份。
所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为8:1。
所述的苦参和迷迭香提取物的制备方法同实施例1。
所述的积雪草提取物通过渗漉法制备得到,所述的提取溶剂为体积百分比浓度为30%的乙醇水溶液。
所述的积雪草提取物的制备方法同实施例1。
所述的黄芩提取物的制备方法同实施例1。
所述的芦荟提取物的制备方法同实施例1。
所述的增粘剂为黄原胶和羟乙基纤维素的混合物,其质量比为3:1。所述的黄原胶为购自西安泽隆生物技术有限公司的化妆品级产品。羟乙基纤维素,CAS:0255-10-7,购自广州博峰化工科技有限公司。所述的高分子保湿剂选自透明质酸钠,为购自西安泽隆生物技术有限公司的化妆品级产品。
所述的银离子溶液为壳聚糖改性银离子溶液。
所述的银离子溶液的制备方法同实施例1。
所述的抗菌、祛痘、抗皱的银离子保湿面膜液的制备方法同实施例1。所述的pH调节剂为苹果酸或三乙醇胺。
实施例5:
实施例5提供了一种抗菌、祛痘、抗皱的银离子保湿面膜液,按重量份计,至少包括以下组分:水60份、苦参和迷迭香提取物3份、积雪草提取物6份、黄芩提取物2份、芦荟提取物1.5份、增粘剂0.8份、甘草酸二钾1.3份、高分子保湿剂1.2份、丙二醇4份、1,3-丁二醇1.5份、苯氧乙醇0.15份、银离子溶液0.003份。
所述的苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为8:1。
所述的苦参和迷迭香提取物的制备方法同实施例1。
所述的积雪草提取物通过渗漉法制备得到,所述的提取溶剂为体积百分比浓度为30%的乙醇水溶液。
所述的积雪草提取物的制备方法同实施例1。
所述的黄芩提取物的制备方法同实施例1。
所述的芦荟提取物的制备方法同实施例1。
所述的增粘剂为黄原胶和羟乙基纤维素的混合物,其质量比为1.6:1。所述的黄原胶为购自西安泽隆生物技术有限公司的化妆品级产品。羟乙基纤维素,CAS:0255-10-7,购自广州博峰化工科技有限公司。所述的高分子保湿剂选自透明质酸钠,为购自西安泽隆生物技术有限公司的化妆品级产品。
所述的银离子溶液为壳聚糖改性银离子溶液。
所述的银离子溶液的制备方法同实施例1。
所述的抗菌、祛痘、抗皱的银离子保湿面膜液的制备方法同实施例1。所述的pH调节剂为苹果酸或三乙醇胺。
对比例1:
对比例1的具体实施方式同实施例5,不同之处在于,不包括苦参和迷迭香提取物。
对比例2:
对比例2的具体实施方式同实施例5,不同之处在于,将苦参和迷迭香提取物更换为等质量的苦参提取物和迷迭香提取物的混合物。所述的苦参/迷迭香提取物的制备方法,至少包括以下步骤:按重量份,取干燥的苦参根/迷迭香干叶,粉碎后过40目筛,将其混合均匀,投入反应釜中,加入乙醇,苦参根/迷迭香干叶的总质量与乙醇的质量之比为1:3~5,在70~80℃下回流提取,每次提取时间为0.3~2h,共提取两次,合并提取液;向提取液中加入活性炭,活性炭与提取液的质量比为2~7:100,搅拌30min,过500目滤布,减压浓缩至干,得到所述的苦参/迷迭香提取物。
对比例3:
对比例3的具体实施方式同实施例5,不同之处在于,将苦参和迷迭香提取物更换为等质量的苦参提取物。
对比例4:
对比例4的具体实施方式同实施例5,不同之处在于,将苦参和迷迭香提取物更换为等质量的迷迭香提取物。
对比例5:
对比例5的具体实施方式同实施例5,不同之处在于,不包括银离子溶液。
对比例6:
对比例6的具体实施方式同实施例5,不同之处在于,所述的银离子溶液的制备方法,至少包括以下步骤:按重量比为1:1:1:1取干燥的中国红玫瑰、槐花、丁香、薰衣草,粉碎并混合均匀,向其中加入8倍质量的体积百分比浓度为18%的乙醇水溶液,55℃提取7h,过滤,减压浓缩至无乙醇,得到植物提取物;配置浓度为12.5mmol/L的AgNO3水溶液,逐滴加入所述植物提取物,所述植物提取物和AgNO3水溶液的体积比为40:1,搅拌,30min后得到所述的银离子溶液。
对比例7:
对比例7的具体实施方式同实施例5,不同之处在于,所述的银离子溶液的制备方法,至少包括以下步骤:取壳聚糖,将其溶于体积分数为2%的醋酸水溶液,配置质量浓度为2%的壳聚糖醋酸水溶液,搅拌至壳聚糖完全溶解;取壳聚糖醋酸溶液,加入浓度为12.5mmol/L的AgNO3水溶液,壳聚糖醋酸溶液和AgNO3水溶液的体积比为25:1,搅拌25min;逐滴加入浓度为5mmol/L的柠檬酸钠溶液,所述柠檬酸钠溶液和AgNO3水溶液的体积比为40:1,搅拌,30min后得到所述的银离子溶液。
性能评价:
利用实施例1~5以及对比例1~7得到抗菌、祛痘、抗皱的银离子保湿面膜液来生产面膜。本发明应用时浸泡无纺布面贴膜,每片浸含保湿面膜液30g。
1.毒理学测试
选用小鼠进行毒理学测试,将实施例1~5的面膜液配置成质量浓度为25%的水溶液进行测试,测试结果如下所示:
a.急性口服毒性:无毒
b.眼睛刺激:非常耐受
c.致敏试验:无致敏
2.面膜性能评价
选取120例女性志愿者,年龄在20~40岁之间,自愿者选择标准:敏感性肌肤、脸部有痘痘或红斑的女性志愿者。将自愿者随机分为12组,每组10人,分别使用实施例1~5和对比例1~7的面膜。各组志愿者清洁面部后,使用相应的面膜,将面膜朝内展开轻敷于面部,轻按至完全贴合,敷15min,每周使用3次,4周后对面膜的补水效果、止痒、刺激性、消炎效果进行评价,汇总数据并计算平均值,评价方法为:
a.补水效果:5分-效果很好;4分-效果好;3分-效果一般;2分-没有效果;
b.止痒:5分-效果很好;4分-效果好;3分-效果一般;2分-没有效果;
c.刺激性:5分-无刺激;4分-有点刺激,但是没有红、痒;2分-有刺激,有红、痒;2分-刺激,红、肿;
d.消炎效果:5分-效果很好,痘痘或红斑的肿痛消退;4分-效果好,痘痘或红斑没有痛感;3分-效果一般,痘痘或红斑的肿痛还在;2分-没有效果,痘痘或红斑肿痛严重。
表1
补水效果 | 止痒 | 刺激性 | 消炎效果 | |
实施例1 | 3.9 | 4.0 | 4.8 | 3.9 |
实施例2 | 3.8 | 4.1 | 4.7 | 4.0 |
实施例3 | 4.0 | 4.4 | 5 | 4.2 |
实施例4 | 4.2 | 4.5 | 5 | 4.3 |
实施例5 | 4.5 | 4.7 | 5 | 4.4 |
对比例1 | 3.2 | 3.0 | 3.6 | 2.5 |
对比例2 | 3.6 | 3.3 | 3.2 | 3.3 |
对比例3 | 3.3 | 3.1 | 2.5 | 2.9 |
对比例4 | 3.4 | 3.1 | 2.6 | 3.0 |
对比例5 | 3.8 | 3.8 | 5 | 3.5 |
对比例6 | 3.5 | 2.8 | 3.4 | 3.2 |
对比例7 | 3.6 | 3.2 | 3.7 | 3.0 |
3.稳定性效果评价
a.将面膜液放置在(45±2)℃电热恒温培养箱中30天,恢复室温后观察其稳定性;b.将面膜液放置在(-5±2)℃的电冰箱中30天,恢复室温后观察其稳定性。
观察项目:面膜液透明性、沉淀、气味变化等,若面膜液仍然保持透明、无沉淀、无气味变化,则记录为稳定,否则记录为不稳定。测试结果如表2所示。
4.杀菌性能
a.对金黄色葡萄球菌、大肠杆菌的抑制试验
将实施例1~5和对比例1~7制得的面膜剪成5×5cm2的样片,将其置于封闭环境(室温,正常湿度),在所述的封闭环境中放置敞口培养的大肠杆菌培养物、金黄色葡萄球菌培养物、白色假丝酵母菌培养物和链球菌培养物,放置12h后,测量所述的样片上的菌落数(CFU/mL),具体测量方法是取出所述的样品置于100mL的去离子水中,浸泡3h,过滤,取1mL试样在37℃下培养48h,进行菌落总数测定。
b.对痤疮丙酸杆菌的抑制试验
现在大家普遍认为痤疮丙酸杆菌在毛囊中的大量繁殖是诱发痤疮或痘痘并导致其恶化的一种非常重要的因素,因此,研究对痤疮丙酸杆菌的抑制作用是评价产品祛痘功效的一个重要方法。
具体测试方法:(1)称取18.5g生物合成人胰岛素(BHI)粉末溶于500mL水中,灭菌后制成BHI培养基,将痤疮丙酸杆菌菌株接种到BHI培养基中,在厌氧发生袋中37℃厌氧培养48h并振摇均匀备用,另取少量菌株涂于载玻片上,采用革兰染色的方法固定染色,然后将其置于100×100的油镜下执行镜检,镜下可见紫色杆菌,微弯呈棒状或杆状,无杂菌生长。
(2)将痤疮丙酸杆菌培养的溶菌溶液稀释100倍(OD600约为0.02)。将实施例1~5和对比例1~7制得的面膜液分别配置成200mg/mL的水溶液,倍比稀释成100、50.0、25.0、12.5mg/mL的不同浓度样品溶液。
(3)向无菌96孔板中每孔加入上述稀释的含有痤疮丙酸杆菌的溶液90μL,再加入稀释的样品溶液10μL,使得药物终浓度为20mg/mL、10mg/mL、5mg/mL、2.5mg/mL和1.25mg/mL;以90μL菌液加10μL无菌生理盐水作为阴性对照;阳性对照是由10μg/mL、5μg/mL和2.5μg/mL的氨苄青霉素钠溶液组成。将上述标本转移入恒温摇床培养箱37℃,250r/min厌氧培养48h。
(4)用酶标仪测定每组样品与痤疮丙酸杆菌混合后溶液OD600的吸光值。已完全没有光吸收孔的药物浓度作为最小抑菌浓度。取没有光吸收的菌液常规行革兰染色后用显微镜检查来证明有无痤疮丙酸杆菌的生长。
(5)采用平板培养复测的方法检测出针对上述型号痤疮丙酸杆菌的最小抑菌浓度值,结果如下表所示。
表2性能表征测试
本发明的面膜液性质稳定,在高低温条件下放置透明性、沉淀、气味均不产生变化,并且对大肠杆菌、金黄色葡萄球菌、白色假丝酵母菌和链球菌还有痤疮丙酸杆菌均有明显的抑菌效果,同时对皮肤无刺激,具有优异的补水、抗皱、止痒、消炎效果。
前述的实例仅是说明性的,用于解释本发明所述方法的一些特征。所附的权利要求旨在要求可以设想的尽可能广的范围,且本文所呈现的实施例仅是根据所有可能的实施例的组合的选择的实施方式的说明。因此,申请人的用意是所附的权利要求不被说明本发明的特征的示例的选择限制。在权利要求中所用的一些数值范围也包括了在其之内的子范围,这些范围中的变化也应在可能的情况下解释为被所附的权利要求覆盖。
Claims (8)
1.一种抗菌、祛痘、抗皱的银离子保湿面膜液,其特征在于,按重量份计,由以下组分组成:苦参和迷迭香提取物0.5~4份、积雪草提取物2~10份、黄芩提取物0.6~3份、芦荟提取物0.5~3份、银离子溶液0.001~0.03份、水40~70份、增粘剂0.1~1.6份、甘草酸二钾0.1~2份、高分子保湿剂0.01~3份、丙二醇1~5份、1,3-丁二醇1~3份、苯氧乙醇0.1~1份,所述的银离子溶液为壳聚糖改性银离子溶液,所述的银离子溶液的制备方法,包括以下步骤:按重量比为1:1:1:1取干燥的中国红玫瑰、槐花、丁香、薰衣草,粉碎并混合均匀,向其中加入8倍质量的体积百分比浓度为18%的乙醇水溶液,55℃提取7h,过滤,减压浓缩至无乙醇,得到植物提取物;取壳聚糖,将其溶于体积分数为2%的醋酸水溶液,配置质量浓度为2%的壳聚糖醋酸水溶液,搅拌至壳聚糖完全溶解;取壳聚糖醋酸溶液,加入浓度为12.5mmol/L的AgNO3水溶液,壳聚糖醋酸溶液和AgNO3水溶液的体积比为25:1,搅拌25min;逐滴加入所述植物提取物,所述植物提取物和AgNO3水溶液的体积比为40:1,搅拌,30min后得到所述的银离子溶液;所述苦参和迷迭香提取物,其制备原料中苦参和迷迭香的质量比为8:1,所述苦参和迷迭香提取物的制备方法为:按重量份,取干燥的苦参根和迷迭香干叶,粉碎后过40目筛,将其混合均匀,投入反应釜中,加入乙醇,苦参根和迷迭香干叶的总质量与乙醇的质量之比为1:5,在70~80℃下回流提取,每次提取时间为1.5h,共提取两次,合并提取液;向提取液中加入活性炭,活性炭与提取液的质量比为5:100,搅拌30min,过500目滤布,减压浓缩至干,得到所述的苦参和迷迭香提取物;所述的积雪草提取物的制备方法,包括以下步骤:取干燥的积雪草全草粉碎至颗粒度为40目,将其装填入渗漉柱内,压实测得积雪草堆积体积,加入0.8倍积雪草堆积体积的提取溶剂,在50℃浸泡1h;将2倍积雪草堆积体积的提取溶剂自上而下流经渗漉柱进行渗漉提取,提取溶剂流速为0.5倍积雪草堆积体积/小时,渗漉提取的温度为50℃,收集渗漉液,减压浓缩回收溶剂得到积雪草提取物;所述的提取溶剂为体积百分比浓度为70%的乙醇水溶液;所述的黄芩提取物的制备方法,包括以下步骤:取黄芩,粉碎过100目筛,加入8倍质量的水,在5℃和pH=5的条件下搅拌、超声,频率为40kHz,功率为100W提取两次,每次30min,合并提取液,过滤,使用苹果酸将滤液的pH调至5,加热至50℃并保温12h,过滤收集沉淀,水洗、干燥,得到所述的黄芩提取物;所述的芦荟提取物的制备方法,包括以下步骤:割取一定量的新鲜芦荟叶片,用刀削去外皮,切块,放到榨汁机里榨取汁液,用四层纱布过滤,滤渣弃掉,滤液置冰箱3~6℃中保存10h,然后再用四层纱布过滤,弃去渣,得到所述的芦荟提取物。
2.如权利要求1所述的抗菌、祛痘、抗皱的银离子保湿面膜液,其特征在于,按重量份计,由以下组分组成:水50~65份、苦参和迷迭香提取物1.5~4份、积雪草提取物5~10份、黄芩提取物0.6~2份、芦荟提取物1~3份、增粘剂0.5~1.4份、甘草酸二钾0.5~1.6份、高分子保湿剂0.2~2.4份、丙二醇1~5份、1,3-丁二醇1~3份、苯氧乙醇0.1~0.5份、银离子溶液0.001~0.01份。
3.如权利要求2所述的抗菌、祛痘、抗皱的银离子保湿面膜液,其特征在于,所述的增粘剂为黄原胶、卡波姆、聚乙烯醇、明胶、葡糖酸、玉米淀粉、癸基葡聚糖、聚乙烯吡咯烷酮、羟乙基纤维素、乙酸纤维素、乙酸-丁酸纤维、甲基纤维素、羧甲基纤维素钠中的至少一种。
4.如权利要求3所述的抗菌、祛痘、抗皱的银离子保湿面膜液,其特征在于,所述的增粘剂为黄原胶和羟乙基纤维素的混合物,其质量比为1~3:1。
5.如权利要求2所述的抗菌、祛痘、抗皱的银离子保湿面膜液,其特征在于,所述的高分子保湿剂选自透明质酸钠、吡咯烷酮羧酸钠、聚谷氨酸钠、芦荟多糖、海藻多糖中的至少一种。
6.一种面膜,其特征在于,所述的面膜包括:作为载体的面膜基质,以及如权利要求1~5任一项所述的抗菌、祛痘、抗皱的银离子保湿面膜液,所述的面膜基质中吸附有所述的抗菌、祛痘、抗皱的银离子保湿面膜液。
7.如权利要求6所述的面膜,其特征在于,所述的面膜基质的材质选自无纺布、蚕丝、水凝胶、纯棉纤维、粘胶纤维、天丝纤维、竹炭纤维中的至少一种。
8.如权利要求7所述的面膜,其特征在于,所述蚕丝为概念隐形蚕丝。
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