CN108772358A - A kind of new automatic more reagent strip cleaning magnetic beads mechanism - Google Patents
A kind of new automatic more reagent strip cleaning magnetic beads mechanism Download PDFInfo
- Publication number
- CN108772358A CN108772358A CN201810393452.9A CN201810393452A CN108772358A CN 108772358 A CN108772358 A CN 108772358A CN 201810393452 A CN201810393452 A CN 201810393452A CN 108772358 A CN108772358 A CN 108772358A
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- CN
- China
- Prior art keywords
- magnetosheath
- reagent strip
- magnet
- stepper motor
- magnetic beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 51
- 239000011324 bead Substances 0.000 title claims abstract description 48
- 238000004140 cleaning Methods 0.000 title claims abstract description 44
- 230000007246 mechanism Effects 0.000 title claims abstract description 24
- 239000007788 liquid Substances 0.000 claims 1
- 238000012864 cross contamination Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B1/00—Cleaning by methods involving the use of tools
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of new automatic more reagent strip cleaning magnetic beads mechanisms, including the first stepper motor, the second stepper motor, magnetosheath moving mass, magnet movement block and reagent strip, first stepper motor connects magnetosheath moving mass, it is provided with magnetosheath fixing axle on the magnetosheath moving mass, second stepper motor connects magnet movement block, it is provided with bar magnet on the magnet movement block, the lower section of the bar magnet is reagent strip, and the dress hole of magnetosheath, the hole of magnetic bead to be cleaned, the hole of cleaning solution and reacting hole are provided on the reagent strip.The new automatic more reagent strip cleaning magnetic beads mechanism of one kind provided by the present invention, cleaning speed are fast；Magnetosheath used is disposable no cross contamination；Magnetic bead is evenly distributed on magnetosheath when cleaning, and cleaning is more thorough；More parts of magnetic beads can once be cleaned.
Description
Technical field
The present invention relates to medical detecting Instrument technical field, more particularly to a kind of new automatic more reagent strips clean magnetic bead
Mechanism.
Background technology
Medical test be with modern physics chemical method, means carry out medical diagnosis technology, it mainly study how
It is clinical diagnosis by laboratory technique, medical instruments and equipment, treatment provides foundation, the various photoelectric instruments of technology requirement use
And chemical reagent completes experimental analysis.It has a wide range of applications in the laboratory of big-and-middle universities and colleges, scientific research institutions, in environmental protection, occupation
Health, public health, hospital, animals and plants research institute are also widely used；The same fashionable dress of full-automatic more reagent strip cleaning magnetic bead mechanisms
Multiple magnetosheaths are carried, each magnetosheath is sleeved on bar magnet, the magnetosheath being sleeved on bar magnet is inserted into the magnetic bead to be cleaned of reagent strip, and inhale
Then attached magnetic bead is moved on in another hole of reagent strip and is cleaned, after the completion of cleaning, be moved to another hole of reagent strip position,
Magnetosheath is abandoned, all processes are all performed fully automatic.
Existing more reagent strip cleaning magnetic beads mechanism is cleaning solution to be first added magnetic bead is then adsorbed on cleaning with magnet
Unbonded substance on one side, is then siphoned away with cleaning needle, wants repeated multiple times in this way by hole, and magnetic bead is easy to be sucked away, cross contamination
With do not wash clean clearly.Therefore, existing more reagent strip cleaning magnetic beads mechanism will also be improved further.
Invention content
It is that cleaning solution is first added then to be adsorbed magnetic bead with magnet for above-mentioned existing more reagent strip cleaning magnetic beads mechanism
The hole of cleaning on one side, then unbonded substance is siphoned away with cleaning needle, wants repeated multiple times in this way, magnetic bead is easy to be sucked away,
Cross contamination and the sordid problem of cleaning, the technical problem to be solved in the present invention is to provide a kind of new automatic more reagent strips
Clean magnetic bead mechanism.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：
A kind of new automatic more reagent strip cleaning magnetic beads mechanism, including the first stepper motor, the second stepper motor, magnetosheath
Moving mass, magnet movement block and reagent strip, first stepper motor connect magnetosheath moving mass, are arranged on the magnetosheath moving mass
There are magnetosheath fixing axle, second stepper motor to connect magnet movement block, bar magnet, the magnetic are provided on the magnet movement block
The lower section of stick is reagent strip, and the dress hole of magnetosheath, the hole of magnetic bead to be cleaned, the hole of cleaning solution and reaction are provided on the reagent strip
Hole.
The preferred embodiment of said program is：Further include lower support column, bottom plate is provided on the lower support column, it is described
Upper support column, the upper support column upper mounted plate, first stepper motor and the second stepper motor are provided on bottom plate
It is arranged on upper mounted plate, the first guide post and the second guide post is provided on the bottom plate.
The preferred embodiment of said program is：Magnetosheath moving mass, the magnetosheath moving mass are provided in first guide post
On be provided with the first screw component, first screw component is connect with the first stepper motor.
The preferred embodiment of said program is：Magnet movement block, the magnet movement block are provided in second guide post
On be provided with the second screw component, second screw component is connect with the second stepper motor.
The preferred embodiment of said program is：The first stepper motor sensor and the second stepping are provided on fixed plate
Electromechanical transducer.
The preferred embodiment of said program is：Magnetosheath sensor, the magnet movement block are provided on the magnetosheath moving mass
On be provided with magnet sensor.
The preferred embodiment of said program is：Magnet fixed link, the magnet fixed link are provided on the magnet movement block
On be provided with bar magnet.
Advantageous effect：The new automatic more reagent strip cleaning magnetic beads mechanism course of work of one kind of the present invention is as follows,
1) take magnetosheath, the rotation of the first stepper motor that magnetosheath moving mass, magnetosheath moving mass is driven to be inserted into reagent after moving down
It in the magnetosheath of item, moves then up, such magnetosheath is just removed；
2) magnetic bead is taken, when hole of the reagent strip equipped with magnetic bead to be cleaned, which is moved to, to be removed immediately below magnetosheath, the first stepping
Motor rotates, and is inserted into after driving magnetosheath moving mass, magnetosheath to move down in hole of the reagent strip equipped with magnetic bead to be cleaned, while second
Stepper motor rotation drives magnet movement block to be moved down along the second guide post, to which magnet fixed link and bar magnet are also to moving down
Dynamic, such bar magnet is put into magnetosheath, and magnetosheath paripheral zone is made to be magnetic, and at this moment magnetosheath is equipped with the hole of magnetic bead to be cleaned in reagent strip
It inside stays for some time, to which the magnetic bead in hole is uniformly adsorbed on magnetosheath surface.
3) magnetic bead is cleaned, when hole of the reagent strip equipped with cleaning solution, which is moved to, to be removed immediately below magnetosheath, the first stepping electricity
Machine rotates, and is inserted into after driving magnetosheath moving mass, magnetosheath to move down in the hole equipped with cleaning solution, while the second stepper motor rotates
Magnet movement block is driven to be moved down along the second guide post, to which magnet fixed link and bar magnet also move up, such bar magnet is just
Into in magnetosheath, magnetosheath paripheral zone is made to be magnetic, at this moment magnetosheath stays in hole of the reagent strip equipped with cleaning solution, at this moment bar magnet
It is repeatedly fast moved up and down simultaneously with magnetosheath and washes unbonded substance.
4) magnetic bead is discharged, bar magnet and magnetosheath move upward out in reagent strip hole after cleaning magnetic bead, then the reacting hole of reagent strip
It is moved to immediately below magnetosheath, then magnetosheath and bar magnet are moved down into the reacting hole of reagent strip, and then bar magnet moves out magnetosheath
It is interior, it at this moment loses magnetism around magnetosheath, magnetic bead is released in the reacting hole of reagent strip.
The new automatic more reagent strip cleaning magnetic beads mechanism of one kind provided by the present invention, cleaning speed are fast；Magnetosheath used
It is disposable no cross contamination；Magnetic bead is evenly distributed on magnetosheath when cleaning, and cleaning is more thorough；More parts of magnetic can once be cleaned
Pearl.
Description of the drawings
Fig. 1 is the pre-structure schematic diagram that a kind of new automatic more reagent strips of the present invention clean magnetic bead mechanism；
Fig. 2 is the pre-structure schematic diagram that a kind of new automatic more reagent strips of the present invention clean magnetic bead mechanism；
Fig. 3 is the sectional view that a kind of new automatic more reagent strips of the present invention clean magnetic bead mechanism.
In figure：Support column under 101-, 102- bottom plates, the first guide posts of 103-, 104- upper mounted plates, 105-
Second guide post, 105- upper support columns, the first screw components of 201-, 202- magnetosheath moving mass, the first stepper motors of 203-,
204- magnetosheath sensors, 205- the first stepper motor sensors, the second screw components of 301-, 302- magnet movement blocks,
The second stepper motors of 303-, 304- magnet sensors, 305- the second stepper motor sensors, 401- bar magnets, 402- magnet
Fixed link, 403- magnetosheath fixing axles, 404- magnetosheaths, 405- reagent strips.
Specific implementation mode
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, below in conjunction with the accompanying drawings to the present invention
Specific implementation mode be described in detail.Many details are elaborated in the following description in order to fully understand this hair
It is bright.But the invention can be embodied in many other ways as described herein, those skilled in the art can be not
Similar improvement is done in the case of violating intension of the present invention, therefore the present invention is not limited by following public specific embodiment.
It should be noted that when element is referred to as " being fixed on " another element, it can be directly on another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it can be directly connected to
To another element or it may be simultaneously present centering elements.
Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to the technical field of the present invention
The normally understood meaning of technical staff is identical.Used term is intended merely to description tool in the description of the invention herein
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term " and or " used herein includes one or more phases
Any and all combinations of the Listed Items of pass.
As shown in Figure 1, 2, 3, the new automatic more reagent strip cleaning magnetic beads mechanism of one kind of the present embodiment, including the first step
Stepper motor 203, the second stepper motor 303, magnetosheath moving mass 202, magnet movement block 302 and reagent strip 405, first stepping
Motor 203 connects magnetosheath moving mass 202, and magnetosheath fixing axle 403 is provided on magnetosheath moving mass 202, and the second stepper motor 303 connects
Magnet movement block 302 is connect, bar magnet 401 is provided on magnet movement block 302, the lower section of bar magnet 401 is reagent strip 405, reagent strip
The dress hole of magnetosheath, the hole of magnetic bead to be cleaned, the hole of cleaning solution and reacting hole are provided on 405.
Wherein, further include lower support column 101, bottom plate 102 is provided on lower support column 101, is set on bottom plate 102
It is equipped with upper support column 106,106 upper mounted plate 104 of upper support column, the first stepper motor 203 and the setting of the second stepper motor 303 exist
On upper mounted plate 104, the first guide post 103 and the second guide post 105 are provided on bottom plate 102.
Wherein, it is provided with magnetosheath moving mass 202 in the first guide post 103, the first lead screw is provided on magnetosheath moving mass 202
Component 201, the first screw component 201 are connect with the first stepper motor 203.
Wherein, it is provided with magnet movement block 302 in the second guide post 105, the second lead screw is provided on magnet movement block 302
Component 301, the second screw component 301 are connect with the second stepper motor 303.
Wherein, the first stepper motor sensor 205 and the second stepper motor sensor 305 are provided on upper mounted plate 104.
Wherein, it is provided with magnetosheath sensor 204 on magnetosheath moving mass 202, magnet sensing is provided on magnet movement block 302
Device 304.
Wherein, it is provided with magnet fixed link 402 on magnet movement block 302, bar magnet is provided in the magnet fixed link 402
401。
From the above mentioned, invention achieves following technique effects：Cleaning speed is fast；Magnetosheath used is disposably without intersection
Pollution；Magnetic bead is evenly distributed on magnetosheath when cleaning, and cleaning is more thorough；More parts of magnetic beads can once be cleaned.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (7)
1. a kind of new automatic more reagent strip cleaning magnetic beads mechanism, which is characterized in that including the first stepper motor, the second stepping
Motor, magnetosheath moving mass, magnet movement block and reagent strip, first stepper motor connect magnetosheath moving mass, the magnetosheath fortune
Magnetosheath fixing axle is provided on motion block, second stepper motor connects magnet movement block, is provided on the magnet movement block
The lower section of bar magnet, the bar magnet is reagent strip, and the hole of dress magnetosheath, the hole of magnetic bead to be cleaned, cleaning are provided on the reagent strip
The hole of liquid and reacting hole.
2. new automatic more reagent strip cleaning magnetic beads mechanism according to claim 1, which is characterized in that further include lower branch
Dagger is provided with bottom plate on the lower support column, is provided with upper support column on the bottom plate, on the upper support column
Fixed plate, first stepper motor and the second stepper motor are arranged on upper mounted plate, and the is provided on the bottom plate
One guide post and the second guide post.
3. new automatic more reagent strip cleaning magnetic beads mechanism according to claim 2, which is characterized in that described first leads
Be provided with magnetosheath moving mass on column, be provided with the first screw component on the magnetosheath moving mass, first screw component with
First stepper motor connects.
4. new automatic more reagent strip cleaning magnetic beads mechanism according to claim 2, which is characterized in that described second leads
Be provided with magnet movement block on column, be provided with the second screw component on the magnet movement block, second screw component with
Second stepper motor connects.
5. new automatic more reagent strip cleaning magnetic beads mechanism according to claim 2, which is characterized in that fixed
The first stepper motor sensor and the second stepper motor sensor are provided on plate.
6. new automatic more reagent strip cleaning magnetic beads mechanism according to claim 1, which is characterized in that the magnetosheath fortune
It is provided with magnetosheath sensor on motion block, magnet sensor is provided on the magnet movement block.
7. new automatic more reagent strip cleaning magnetic beads mechanism according to claim 1, which is characterized in that the magnet fortune
It is provided with magnet fixed link on motion block, bar magnet is provided in the magnet fixed link.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810393452.9A CN108772358A (en) | 2018-04-27 | 2018-04-27 | A kind of new automatic more reagent strip cleaning magnetic beads mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810393452.9A CN108772358A (en) | 2018-04-27 | 2018-04-27 | A kind of new automatic more reagent strip cleaning magnetic beads mechanism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108772358A true CN108772358A (en) | 2018-11-09 |
Family
ID=64026675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810393452.9A Pending CN108772358A (en) | 2018-04-27 | 2018-04-27 | A kind of new automatic more reagent strip cleaning magnetic beads mechanism |
Country Status (1)
| Country | Link |
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| CN (1) | CN108772358A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210199542A1 (en) * | 2019-11-09 | 2021-07-01 | Sophonix Co., Ltd. | Pipetting device |
| WO2021196464A1 (en) * | 2020-03-30 | 2021-10-07 | 北京美联泰科生物技术有限公司 | Cleaning apparatus |
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| JP2702450B2 (en) * | 1994-06-16 | 1998-01-21 | ベーリンガー・マンハイム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Method for magnetically separating test components in liquid |
| CN2890059Y (en) * | 2006-01-24 | 2007-04-18 | 陈晓汀 | Nucleic acid extracting instrument |
| CA2676042A1 (en) * | 2007-02-08 | 2008-08-14 | Biokit, S.A. | Magnetic particle washing station |
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| CN203426088U (en) * | 2013-08-22 | 2014-02-12 | 钟伟明 | Magnetic bead washing device |
| CN105420074A (en) * | 2016-01-19 | 2016-03-23 | 山西振东基赛生物科技有限公司 | Multifunctional biological substance separating device |
| CN106916739A (en) * | 2017-05-04 | 2017-07-04 | 广州和实生物技术有限公司 | A kind of single group of extracting is knitted sample nucleic acid and surveys the automatic extracting instrument of OD values |
| CN107525922A (en) * | 2017-09-21 | 2017-12-29 | 苏州新波生物技术有限公司 | A kind of updraft type magnetic bead transfer device and its magnetic bead transfer method |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2702450B2 (en) * | 1994-06-16 | 1998-01-21 | ベーリンガー・マンハイム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Method for magnetically separating test components in liquid |
| CN2890059Y (en) * | 2006-01-24 | 2007-04-18 | 陈晓汀 | Nucleic acid extracting instrument |
| CA2676042A1 (en) * | 2007-02-08 | 2008-08-14 | Biokit, S.A. | Magnetic particle washing station |
| CN102172910A (en) * | 2011-01-26 | 2011-09-07 | 上海铭源数康生物芯片有限公司 | Device for fetching and releasing magnetic sleeve |
| CN203426088U (en) * | 2013-08-22 | 2014-02-12 | 钟伟明 | Magnetic bead washing device |
| CN105420074A (en) * | 2016-01-19 | 2016-03-23 | 山西振东基赛生物科技有限公司 | Multifunctional biological substance separating device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210199542A1 (en) * | 2019-11-09 | 2021-07-01 | Sophonix Co., Ltd. | Pipetting device |
| US11971334B2 (en) * | 2019-11-09 | 2024-04-30 | Sophonix Co., Ltd. | Pipetting device |
| WO2021196464A1 (en) * | 2020-03-30 | 2021-10-07 | 北京美联泰科生物技术有限公司 | Cleaning apparatus |
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Application publication date: 20181109 |