CN108744261B - Soluble microneedle patch drug delivery device - Google Patents
Soluble microneedle patch drug delivery device Download PDFInfo
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- CN108744261B CN108744261B CN201810699559.6A CN201810699559A CN108744261B CN 108744261 B CN108744261 B CN 108744261B CN 201810699559 A CN201810699559 A CN 201810699559A CN 108744261 B CN108744261 B CN 108744261B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
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- A—HUMAN NECESSITIES
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
Abstract
The invention provides a soluble microneedle patch drug delivery device, comprising: a body assembly, and a microneedle drug introduction assembly coupled to the body assembly; the microneedle medicine introduction assembly comprises a microneedle medicine administration accelerating dissolution part and a microneedle medicine administration pressure sensing part; one end of the microneedle administration accelerating dissolution part is connected with the main body component, and the other end is connected with the microneedle administration pressure sensing part; the microneedle drug delivery pressure sensing part comprises a pressure sensing layer and a pressure sensor connected with the pressure sensing layer; and the microneedle drug delivery pressure sensing part is used for placing a microneedle patch on the pressure sensing layer so as to facilitate drug delivery to a drug delivery area through the microneedle patch and obtain a drug delivery pressure value through the pressure sensor. The invention realizes transdermal drug delivery by utilizing the soluble microneedle patch by the pressing force suitable for the skin of the patient, improves the drug delivery efficiency of the patch in application, ensures that the drug components carried by the microneedle are truly absorbed by the skin, and improves the user experience.
Description
Technical Field
The invention belongs to the technical field of microneedles, and particularly relates to a soluble microneedle patch drug delivery device.
Background
The soluble microneedle technology is to conduct medicine transdermally by means of a soluble microneedle patch, and act on the skin surface in a manner similar to a band-aid. The medicine applying part of the soluble microneedle medicine patch consists of hundreds of soluble microneedles containing active medicines, and the reason that the microneedles can be absorbed by the skin is that the materials for manufacturing the microneedles have good water solubility, and the microneedles can be naturally dissolved after penetrating through the stratum corneum of the skin to contact with the moisture deep in the skin, so that the medicines are absorbed by the skin.
At present, the soluble microneedle patch is used by pressing the patch forcefully after the patch is manually attached to the skin by a user, so that the microneedles on the patch penetrate through the stratum corneum, and the purpose that the microneedles and the medicines carried by the microneedles are absorbed by the skin is achieved.
However, the existing soluble microneedle patches have the following two problems when in use: firstly, the process of dissolving and absorbing the micro needle of the soluble micro needle patch by the skin is slower, generally 1-8 hours are needed, and in order to ensure that the medicine is fully absorbed by the skin, the micro needle patch needs to be stuck on the surface of the skin for a long time, so that the actual use experience of the product is poor to a great extent; secondly, the different users have the differences of age and sex, so that the skin condition and the stratum corneum thickness of the different users have great differences, the pressing force of the different users is different, the user is difficult to grasp the pressure suitable for the skin of the user, and the soluble micro-needles effectively penetrate the skin, so that the medicine carried by the micro-needles cannot be really absorbed by the skin.
Disclosure of Invention
Based on the above-mentioned problems, a primary object of the present invention is to provide a soluble microneedle patch delivery device, which solves the drawbacks and disadvantages of the prior art.
In order to solve the above problems, the present invention provides a soluble microneedle patch delivery device comprising:
a body assembly, a microneedle drug introduction assembly coupled to the body assembly; wherein,
the microneedle drug introduction assembly comprises a microneedle drug administration accelerating dissolution part and/or a microneedle drug administration pressure sensing part;
one end of the microneedle administration accelerating dissolution part is connected with the main body component, and the other end is connected with the microneedle administration pressure sensing part;
the microneedle drug delivery pressure sensing part comprises a pressure sensing layer and a pressure sensor connected with the pressure sensing layer;
the microneedle drug delivery pressure sensing part is used for placing a microneedle patch on the pressure sensing layer so as to facilitate drug delivery to a drug delivery area through the microneedle patch and obtain a drug delivery pressure value through the pressure sensor.
Preferably, the main body assembly comprises a main body housing, and a processor and a power supply assembly arranged in the main body housing;
the power supply assembly is used for supplying power to the soluble microneedle patch drug delivery device;
The processor is used for processing data of the soluble microneedle patch administration device in the administration process;
the processor is electrically connected with the pressure sensor.
Preferably, the main body assembly further comprises a pressure indicator lamp, a controller and a display screen which are arranged on the main body shell;
the pressure indicator lamp, the controller and the display screen are electrically connected with the processor;
the pressure indicator lamp is used for feeding back according to the pressure data acquired by the pressure sensor;
the controller is used for setting parameters and controlling a switch of the soluble microneedle patch administration device;
the display screen is used for displaying pressure data of the microneedle administration pressure sensing part.
Preferably, the microneedle administration accelerating dissolution comprises one or more of a heating unit, an ultrasonic vibration unit, and a micro-current control unit.
Preferably, the heating unit comprises a heating plate, a temperature sensor and a heating control circuit;
the heating plate is electrically connected with the heating control circuit;
the temperature sensor is electrically connected with the heating control circuit and the processor.
Preferably, the ultrasonic vibration unit comprises a transducer, an ultrasonic generation module and a bridge type amplifying circuit;
The ultrasonic generating module transmits the vibration signal generated by the ultrasonic generating module to the bridge type amplifying circuit; and, the bridge amplifying circuit outputs the corresponding pulse and loads the pulse to the transducer so as to generate ultrasonic vibration.
Preferably, the micro-current control unit comprises a micro-current converter, a micro-current stimulation generator electrically connected with the micro-current converter, and a micro-current conducting contact;
the micro-current converter is electrically connected with the processor; the micro-current conducting contact is electrically connected with the micro-current stimulation generator and is connected with the microneedle administration pressure sensing part;
the micro-current converter receives a micro-current control instruction of the processor; and, based on the microcurrent control instructions, the microcurrent stimulation generator generates microcurrent stimulation signals and conducts through the microcurrent conduction contacts.
Preferably, the dissolvable microneedle patch delivery device further comprises a laser positioning device;
the laser positioning device comprises a first laser ranging unit, a second laser ranging unit and a laser positioner; the first laser ranging unit, the second laser ranging unit and the laser positioner are electrically connected with the processing unit;
The laser positioning device is arranged on the microneedle drug introduction assembly and is arranged at one end of the microneedle drug introduction assembly, which is away from the main body assembly; the first laser ranging unit, the second laser ranging unit and the laser positioner are arranged on the microneedle medicament introducing assembly in a triangular shape;
the first laser ranging unit and the second laser ranging unit are used for respectively acquiring the boundary distance and the vertical distance of the microneedle introduction device in the administration area;
the laser locator is used for locating the administration area according to the locating instruction of the processor; when the device is used, the soluble microneedle dosing device positions the dosing region through the laser positioner, a coordinate point in the dosing region is obtained to serve as a positioning coordinate point, and the boundary distance of the dosing region taking the positioning coordinate point as the center and the vertical distance of the dosing region are obtained through the first laser ranging unit and the second laser ranging unit based on the positioning coordinate point.
Preferably, the dissolvable microneedle patch delivery device further comprises an audio cue;
The audio prompter is arranged in the main body component; the audio prompter is electrically connected with the processor;
the audio prompter is used for giving a voice prompt for the distance and the direction between the microneedle patch and the administration area based on the positioning instruction of the processor; and prompting the pressure degree of the administration area according to the administration pressure value.
Preferably, the dissolvable microneedle patch delivery device further comprises at least two fixation strap portions connected to the body assembly;
the fixing strap part comprises a strap body connected with the main body component and a fixing connecting piece arranged at one end of the strap body, which is different from the main body component;
when the microneedle drug delivery device is used, the binding band body of the fixing binding band part is used for binding, and the fixing connection piece is used for connecting and fixing, so that the microneedle drug delivery device connected with the main body assembly is conveniently fixed in the drug delivery area.
The invention provides a soluble microneedle patch drug delivery device, which comprises a main body component and a microneedle drug introduction component; wherein, microneedle medicine introduction subassembly includes microneedle administration acceleration dissolving portion and microneedle administration pressure sensing portion. According to the drug delivery device provided by the invention, the drug delivery pressure value can be obtained in real time through the microneedle drug delivery pressure sensing part in the microneedle drug introduction assembly, so that when a user carries out drug delivery by utilizing the microneedle patch, the drug delivery pressure value of the microneedle patch is obtained in real time through the drug delivery device, so that the user can select different drug delivery pressure values according to the skin condition and the skin stratum corneum thickness of the user in the use process, the skin delivery is carried out by utilizing the soluble microneedle patch through the pressure force suitable for the skin of the user, the drug delivery efficiency of the patch in application is improved, the drug components carried by the microneedle are ensured to be really absorbed by the skin, and the user experience is improved.
Drawings
FIG. 1 is a schematic structural view of a soluble microneedle patch delivery device according to a first embodiment of the present application;
FIG. 2 is an enlarged schematic view of a portion of a soluble microneedle patch delivery device according to a first embodiment of the present application;
FIG. 3 is a schematic structural view of a soluble microneedle patch delivery device according to a second embodiment of the present application;
FIG. 4 is a schematic structural view of a soluble microneedle patch delivery device according to a third embodiment of the present application;
FIG. 5 is a perspective view of a dissolvable microneedle patch delivery device according to a fourth embodiment of the present application;
FIG. 6 is a schematic top view of a soluble microneedle patch delivery device according to a fifth embodiment of the present disclosure, with two sides of the fixing strap portions disposed in parallel;
FIG. 7 is a schematic side view of a soluble microneedle patch delivery device according to a fifth embodiment of the present disclosure, showing the side view of the fixing band portions disposed in parallel on both sides;
FIG. 8 is a schematic top view of a soluble microneedle patch delivery device according to a fifth embodiment of the present disclosure, with two sides of the device being crossed and obliquely provided with a fixing strap portion;
fig. 9 is a schematic side view of a soluble microneedle patch delivery device according to a fifth embodiment of the present application, in which fixing band portions are disposed diagonally across from each other.
Reference numerals:
| name of the name | Numbering device | Name of the name | Numbering device |
| Soluble microneedle patch drug delivery device | 1 | Transducer | 12121 |
| Main body assembly | 11 | Micro-current control unit | 1213 |
| Main body shell | 111 | Micro-current converter | 12131 |
| Processor and method for controlling the same | 112 | Microcurrent stimulation generator | 12132 |
| Power supply assembly | 113 | Micro-current conductive contact | 12133 |
| Pressure indicator lamp | 114 | Microneedle administration pressure sensing part | 122 |
| Controller for controlling a power supply | 115 | Pressure sensitive layer | 1221 |
| Display screen | 116 | Pressure sensor | 1222 |
| Microneedle drug delivery assembly | 12 | Laser positioning device | 13 |
| Microneedle administration accelerating dissolution part | 121 | First laser ranging unit | 131 |
| Heating unit | 1211 | Second laser ranging unit | 132 |
| Heating plate | 12111 | Laser positioner | 133 |
| Temperature sensor | 12112 | Audio frequency prompter | 14 |
| Heating control circuit | 12113 | Fixing strap part | 15 |
| Ultrasonic vibration unit | 1212 | Strap body | 151 |
| Ultrasonic wave generating module | 12122 | Fixed connecting piece | 152 |
| Bridge type amplifying circuit | 12123 |
The achievement of the objects, functional features and advantages of the present invention will be further described with reference to the accompanying drawings, in conjunction with the embodiments.
Detailed Description
Embodiments of the present invention are described in detail below, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present invention, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Example 1:
referring to fig. 1 and 2, the present embodiment provides a soluble microneedle patch delivery device 1 comprising:
a body assembly 11 and a microneedle drug introduction assembly 12 coupled to the body assembly 11; wherein,
the microneedle drug introduction assembly 12 includes a microneedle administration accelerating dissolution portion 121 and a microneedle administration pressure sensing portion 122;
one end of the microneedle administration accelerating dissolution portion 121 is connected to the main body assembly 11, and the other end is connected to the microneedle administration pressure sensing portion 122;
The microneedle administration pressure sensing part 122 includes a pressure sensing layer 1221 and a pressure sensor 1222 connected to the pressure sensing layer 1221;
the microneedle administration pressure sensing part 122 is used for placing a microneedle patch on the pressure sensing layer 1221 so as to administer the administration area through the microneedle patch and obtain an administration pressure value through the pressure sensor 1222.
The pressure sensor 1222 (Pressure Transducer) is a device or apparatus that senses a pressure signal and converts the pressure signal into an electric signal that can be used as an output according to a certain rule.
The pressure sensitive layer 1221 is connected to the pressure sensor 1222 and is configured to receive pressing pressure. The pressure sensitive layer 1221 may be provided as a member having elasticity, may be in a compressed state when pressed, and may be restored to its original state when released. Thus, in the using process of the microneedle patch, the force feedback feeling for the using force is provided during pressing.
The microneedle administration acceleration dissolution unit 121 is a component for increasing the dissolution rate of the soluble microneedle patch in the soluble microneedle patch administration device 1. The dissolving of the soluble microneedle patch into the skin can be realized by utilizing the acceleration vibration technology, the heating technology, the ultrasonic technology and the like. The soluble microneedle patch is characterized in that the patch, the substrate and the microneedles are sequentially arranged from outside to inside, and can be soluble components, when the soluble microneedle patch is applied to the skin, the microneedles can penetrate through the stratum corneum of the skin to reach the dermis layer, and dissolution is slowly realized in the stratum corneum layer and the dermis layer of the skin. Generally, the attaching time of the soluble microneedle patch is long, and the medicine can be completely dissolved in 1-8 hours, so that an assembly for improving the dissolution speed is needed to be arranged, thereby realizing high-speed dissolution of the microneedle patch, improving the dissolution efficiency and facilitating the use of the microneedles by users.
The main body assembly 11 may be provided as a hand-held device with a hand grip to facilitate pressing by the user during use.
The body assembly 11 may also have other shapes, such as: the shape is suitable for hand shape and convenient for holding.
The microneedle drug delivery assembly 12 may be circular or square and may conform to the shape of the microneedle patch.
The microneedle administration accelerating dissolution portion 121 is provided on the main body assembly 11, and the microneedle administration pressure sensing portion 122 is provided on the outside of the microneedle administration accelerating dissolution portion 121 for placing a microneedle patch on one surface of the microneedle administration pressure sensing portion 122 different from the microneedle administration accelerating dissolution portion 121. Wherein, the microneedle administration accelerating dissolution portion 121 may be provided with an upper baffle and a lower baffle, and the microneedle patch is disposed between the upper baffle and the lower baffle when placed on the surface of the microneedle administration accelerating dissolution portion 121, and the upper baffle and the lower baffle are made of elastic materials, so as to prevent the gel-like microneedle patch from flowing or stretching to other directions due to the pressing force in the pressing process, which causes the loss of components of the medicine.
In the above description, microneedle arrays for transdermal administration are classified into the following three types according to the state of the art and the materials of construction. (1) silicon microneedles: silicon and silicon dioxide have good sensing performance and electromechanical performance, and are common materials for manufacturing micro-needles. The microneedle processing technology of silicon and silicon dioxide is also mature, but the application and popularization of silicon microneedles are hindered by the high price of silicon materials, the weak strength of silicon needles, the problem of biocompatibility with organism tissues and the like. (2) metallic microneedles: compared with silicon microneedles, the metal materials have lower cost and good mechanical strength, but the metal microneedles can be broken during the skin insertion process, and the biocompatibility is common, so that the adverse effect on the human body caused by long-term retention of the materials in the skin is difficult to predict. (3) soluble microneedles: the potential application risks of the two microneedles limit the industrial production and clinical application of the microneedles. In recent years, the selection of the microneedle materials focuses on biodegradable materials with good biocompatibility, and the soluble microneedles are prepared by taking the biodegradable materials as matrixes, so that the preparation method has the advantages of common microneedles, the problem that the microneedles are difficult to treat once broken in the skin is solved due to the biodegradable characteristics, the drug loading rate of the microneedles is improved to a great extent, and the application range of the microneedles is widened. Therefore, the biodegradable microneedle is expected to be an ideal carrier for a percutaneous drug delivery system. There are various materials for manufacturing the soluble nano-microneedles, such as polyethylene, polypropylene, methacrylic acid, hyaluronic acid, and the like. These materials are also satisfactory in terms of biocompatibility, toughness, and safety, and are ideal materials for the marketization of soluble microneedles. In summary, the application and popularization prospect of the soluble microneedle technology in the field of transdermal drug conduction is clear, and the application value is very good.
At present, the soluble microneedle technology is to conduct medicine through skin in a mode of a soluble microneedle patch, and acts on the surface of skin in a mode similar to a band-aid. The drug delivery part of the soluble microneedle drug patch consists of hundreds of soluble microneedles containing active drugs, and the reason that the microneedles can be absorbed by the skin is that the materials for manufacturing the microneedles have good water solubility, and can be naturally dissolved after penetrating through the stratum corneum of the skin to contact with moisture deep in the skin, so that the microneedles can be absorbed by the skin.
At present, in the use process of the soluble microneedle medicine patch, a user needs to press the patch forcefully after attaching the patch to the skin, so that the microneedles on the patch penetrate through the stratum corneum, and the purpose that the microneedles and medicines carried by the microneedles are absorbed by the skin is achieved.
The embodiment provides a soluble microneedle patch drug delivery device 1, which comprises a main body assembly 11 and a microneedle drug introduction assembly 12; wherein the microneedle drug introducing assembly 12 includes a microneedle administration accelerating dissolution portion 121 and a microneedle administration pressure sensing portion 122. According to the drug delivery device provided by the embodiment, the drug delivery pressure value can be obtained in real time through the microneedle drug delivery pressure sensing part 122 in the microneedle drug introduction component 12, so that when a user performs drug delivery by utilizing the microneedle patch, the drug delivery pressure value of the microneedle patch is obtained in real time by pressing the drug delivery device, and therefore, in the use process, the user can select different drug delivery pressure values according to the skin condition and the skin stratum corneum thickness of the user, and transdermal drug delivery is performed by utilizing the soluble microneedle patch through the pressing force suitable for the skin of the user, the drug delivery efficiency of the patch in application is improved, the drug components carried by the microneedle are ensured to be really absorbed by the skin, and the user experience is improved.
Example 2:
referring to fig. 3, based on the above-described embodiment 1, the present embodiment provides a soluble microneedle patch delivery device 1, wherein the body assembly 11 includes a body housing 111, and a processor 112 and a power supply assembly 113 provided within the body housing 111;
as described above, to ensure the service life of the device, the main body case 111 may be made of a material having a certain high temperature resistance or a certain strength. Or a material of a high-hardness rubber having a certain elasticity, and the like.
The main body housing 111 may have a shape of a hand grip, and specifically may include a main body portion attached to the microneedle drug introduction assembly 12 and a grip portion connected to the main body portion, and the grip portion may have a shock absorbing hand gel made of rubber material or a heat insulating hand gel, so as to prevent discomfort and scald caused by long-term use of the hand arm.
The power supply assembly 113 is used for supplying power to the soluble microneedle patch delivery device 1;
the power supply unit 113 may be dc or ac. The solar cell may be a battery, for example, a lithium battery, and may further include a photovoltaic module, and a small solar panel may be disposed at an outer surface of the main body housing 111 for receiving solar rays, and a photoelectric converter is disposed inside the housing for photoelectric conversion and electrically connected to the lithium battery for real-time storage of converted electric energy. The lithium battery, namely the photovoltaic module, has improved the duration of the device of dosing greatly, on the one hand, has solved the problem of uninterrupted current that uses for a long time, on the other hand is the device power supply through using the new forms of energy, and is more environmental protection.
The processor 112 is configured to process data of the soluble microneedle patch delivery device 1 during a delivery process;
the processor 112 is used for processing data, analyzing signals returned by the sensor, setting parameters, and exchanging data. Through the processor 112, simultaneous processing of various data can be realized, the drug delivery efficiency of the microneedle patch in the attaching process is improved, and the drug delivery process is more intelligent.
In addition, since the processor 112 provided in the present embodiment processes data of a plurality of different components or devices simultaneously, a large amount of operations need to be performed simultaneously, which consumes a large amount of system resources, and the huge amount of operations can cause the processor 112 to operate at a higher temperature to some extent, and an excessively high temperature can reduce the operation efficiency and the service life of the processor 112. Therefore, in this embodiment, a refrigeration component may be disposed on the surface of the processor 112; the refrigeration assembly may include a thermal barrier disposed on a surface of the processor 112, and a refrigeration unit disposed on the thermal barrier. The heat insulating layer may be heat conducting silica gel or ultrathin aluminum alloy heat dissipating fin with thickness of 0.2-0.5 mm.
Wherein, the refrigeration unit can be a refrigeration fan; the liquid refrigeration device may also be a liquid refrigeration device, and may include a refrigeration main body, a cooling liquid inner pipeline disposed in the refrigeration main body, where the refrigeration main body is provided with a cooling liquid inlet and outlet port, and the cooling liquid inner pipeline is connected with the cooling liquid inlet and outlet port, and forms a circulation pipeline with an external cooling liquid outer pipeline and a TEC semiconductor refrigerator, and the refrigeration effect on the CPU processor 112 is achieved through circulation of the cooling liquid. The liquid refrigeration can cool the processor 112 more efficiently and more quickly, and the refrigeration effect is better.
The processor 112 is electrically connected to the pressure sensor 1222.
The body assembly 11 further includes a pressure indicator 114, a controller 115, and a display 116 provided on the body housing 111;
the pressure indicator 114, the controller 115 and the display 116 are all electrically connected to the processor 112;
the pressure indicator 114 is configured to perform feedback according to the pressure data collected by the pressure sensor 1222;
the controller 115 is used for performing parameter setting and control switching on the soluble microneedle patch delivery device 1;
the display 116 is configured to display pressure data of the microneedle administration pressure sensing portion 122.
The pressure indicator 114 is provided on the main body unit 11, and is used for feeding back the pressure value at the time of pressing when the user performs the drug administration by the drug administration device based on the soluble microneedle patch. For example, the pressure indicator light 114 may include two switchable colors, red and blue, the red indicating that pressure is not reached but is in a depressed state, the blue indicating that a preset pressure threshold is reached, the preset pressure threshold is preset, and the pressure indicator light 114 is not illuminated when the administration device is not administering the medication; after the administration is started, pressing the administration device so that when the microneedle penetrates into the stratum corneum, the red light is lighted if the preset pressure threshold is not reached; when the administration pressure value is obtained by the pressure sensor 1222, the blue light blinks when the administration pressure value reaches a preset pressure threshold. The pressure indicator 114 is set to make the user more clear about the force applied when administering the microneedle patch, so that the effective components in the patch more conform to the condition of the personal skin of the user, and the user can administer the patch under the force mastered by the user, thereby improving the user experience.
The pressure indicator 114 may be a color-changeable LED lamp.
The display 116 is used for displaying the pressure data of the microneedle administration pressure sensing part 122. The display 116 may be a touch screen, such as a touch screen, and may be configured to trigger different commands when the user presses the screen with different forces.
Example 3:
referring to fig. 4, based on the above-described embodiment 2, the present embodiment provides a soluble microneedle patch drug delivery device 1 in which the microneedle drug delivery accelerating dissolution 121 includes one or several of a heating unit 1211, an ultrasonic vibration unit 1212, and a micro-current control unit 1213.
Preferably, the method comprises the steps of,
the heating unit 1211 includes a heating plate 12111, a temperature sensor 12112, and a heating control circuit 12113;
the heating plate 12111 is electrically connected to the heating control circuit 12113;
the temperature sensor 12112 is electrically connected to the heating control circuit 12113 and the processor 112.
The microneedle administration accelerating dissolution portion 121 includes the heating unit 1211 described above. Wherein the heating unit 1211 includes a heating plate 12111, a temperature sensor 12112, and a heating control circuit 12113. The heating control circuit 12113 is controlled by the processor 112, the heating plate 12111 is controlled to heat, and the current heating temperature is obtained in real time by the temperature sensor 12112, and the temperature can be set to 40-60 ℃ to heat the soluble microneedle patch, so as to accelerate the dissolution of the patch, and under the heating condition, the medicine can be more quickly permeated into the skin, and the administration speed is improved.
Preferably, the method comprises the steps of,
the ultrasonic vibration unit 1212 includes a transducer 12121, an ultrasonic generation module 12122, and a bridge amplification circuit 12123;
the ultrasonic wave generation module 12122 transmits the vibration signal generated thereby to the bridge amplifying circuit 12123; and, the bridge amplifying circuit 12123 outputs a corresponding pulse and loads the transducer 12121 so as to generate an ultrasonic vibration.
The ultrasonic wave is an acoustic wave with the frequency higher than 20000 hertz, has good directivity and strong penetrating power, is easy to obtain more concentrated acoustic energy, and has long propagation distance in water. Scientists refer to the number of vibrations per second as the frequency of sound, which is in hertz (Hz). The frequency of sound waves which can be heard by human ears is 20Hz-20000Hz. Therefore, sound waves having a frequency higher than 20000 hertz are called "ultrasonic waves". Ultrasound frequencies commonly used for medical diagnostics are 1 megahertz to 30 megahertz.
Transducer 12121 refers to a device that converts electrical energy and acoustic energy into each other. Used in echo sounding device, doppler log and acoustic correlation log. A so-called transmit transducer 12121 that converts electrical energy into acoustic energy; what converts the acoustic energy into electrical energy is a receiving transducer 12121.
In the above description, the ultrasonic generator is a device for converting the commercial power into the high-frequency ac power corresponding to the transducer 12121 to drive the transducer 12121 to operate, and is an important component of the high-power ultrasonic system, and may also be referred to as an electronic box, an ultrasonic driving power supply, and an ultrasonic controller 115. In this embodiment, the ultrasound vibration unit 1212 is used to realize ultrasound of the drug delivery device, so that the soluble microneedle patch is more rapidly dissolved in the skin during high-speed vibration, and the drug or the active ingredient in the microneedle patch is efficiently dissolved.
Preferably, the method comprises the steps of,
the micro-current control unit 1213 includes a micro-current transducer 12131, a micro-current stimulation generator 12132 electrically connected to the micro-current transducer 12131, and micro-current conductive contacts 12133;
the micro-current converter 12131 is electrically connected to the processor 112; the micro-current conductive contact 12133 is electrically connected to the micro-current stimulus generator 12132, and the micro-current conductive contact 12133 is connected to the microneedle administration pressure sensing portion 122;
the micro-current converter 12131 receives micro-current control instructions of the processor 112; and, based on the micro-current control instruction, the micro-current stimulation generator 12132 generates a micro-current stimulation signal and conducts through the micro-current conducting contact 12133.
As described above, through the micro-current control unit 1213, micro-current stimulation is generated, and dissolution of the soluble microneedle and absorption of the drug are accelerated by using low-intensity specific waveform current, and at the same time, skin of the administration area can be stimulated, and a certain massage function is provided, thereby relieving fatigue.
In the present embodiment, the microneedle administration accelerating dissolution 121 includes one or more of a heating unit 1211, an ultrasonic vibration unit 1212, and a micro-current control unit 1213. Wherein, the units of different heating dissolution parts have different functions, the above 3 technologies for accelerating dissolution can be combined for use, and different functional units can be adopted according to microneedle patches with different properties. For example, some drugs need to be used at normal or low temperature, and if a certain decomposition or modification occurs at a high temperature, the heating unit 1211 may not be turned on. By utilizing the various different microneedle administration accelerating dissolution parts 121, the drug administration accelerating dissolution parts are singly used or combined to realize the accelerating dissolution of the drug components in the soluble microneedle patch, improve the administration efficiency and improve the customer experience.
Example 4:
referring to fig. 5, based on the above-described embodiment 2, the present embodiment provides a soluble microneedle patch delivery device 1, wherein the soluble microneedle patch delivery device 1 further includes a laser positioning device 13;
the laser positioning device 13 comprises a first laser ranging unit 131, a second laser ranging unit 132 and a laser positioner 133; the first laser ranging unit 131, the second laser ranging unit 132 and the laser positioner 133 are all electrically connected with the process;
the laser positioning device 13 is arranged on the microneedle medicament introduction assembly 12 and is arranged at one end of the microneedle medicament introduction assembly 12 away from the main body assembly 11; the first laser ranging unit 131, the second laser ranging unit 132 and the laser positioner 133 are arranged on the microneedle drug introducing assembly 12 in a triangular shape;
the first laser ranging unit 131 and the second laser ranging unit 132 are used for respectively acquiring the boundary distance and the vertical distance of the microneedle introduction device in the administration area;
the laser positioner 133 is configured to position the administration area according to positioning instructions of the processor 112;
In use, the soluble microneedle dosing device positions the dosing region by the laser locator 133, obtains a coordinate point within the dosing region as a positioning coordinate point, and obtains a boundary distance of the dosing region centered on the positioning coordinate point and a vertical distance from the dosing region by the first laser ranging unit 131 and the second laser ranging unit 132 based on the positioning coordinate point.
As described above, it should be understood that the laser ranging (laser distance measuring) is performed by using a laser as a light source. Laser ranging is an instrument that uses laser light to accurately measure the distance to a target (also known as laser ranging). The laser distance measuring device emits a very thin laser beam to the target during operation, the photoelectric element receives the laser beam reflected by the target, and the timer measures the time from the emission to the reception of the laser beam and calculates the distance from the observer to the target.
The above-mentioned administration area may be a predetermined coordinate range of the target area, for example, the upper left corner of the entire back is set to x=0, y=0, the lower right corner is set to x=128, y=128, the coordinate range is set to x=45-47, and y=64.5-66.5, and the preset administration area is defined in the area.
The above-mentioned positioning coordinate point is a positioning coordinate point in the administration area of the user found by scanning with the laser positioner 133, and the coordinate point may be a theoretical center coordinate or a coordinate in the administration area of a non-center position, that is, the current coordinate may be set as the positioning coordinate point as long as the user enters the administration area. For example, the back administration area of the user is square, and when the user holds the soluble microneedle administration device, the user moves by the laser positioner 133, and when moving to above the administration area, the laser positioner 133 determines that the area is the administration area, and the coordinate point located by the current laser positioner 133 is the location coordinate point.
The first laser ranging unit 131 and the second laser ranging unit 132 are used to obtain the boundary distance and the vertical distance of the microneedle introduction device in the administration area, respectively. The boundary distance, that is, the nearest distance between each laser ranging unit and the edge of the administration area, and the measurement of the distance may be the distance value between the laser ranging unit with a certain inclination angle and the edge of the administration area of the skin of the user. The two laser ranging units are respectively used for measuring distance values of two ends from the edge of the administration area. In addition, the laser ranging unit may also acquire a vertical distance from the skin, and since the skin of a person is not entirely planar, a part of the area such as the face or the knee has a certain arc shape, for example, a concave area and a convex area, different positions have different ranging distances. In this embodiment, simultaneous ranging for the same target is achieved by means of different laser ranging units. Generating first ranging data corresponding to the first laser ranging unit 131 and second ranging data corresponding to the second laser ranging unit 132; averaging the first ranging data and the second ranging data results in a more accurate mean of the dosing distance relative to the dosing device.
When a user performs drug administration through the device provided by the application, a part of the area is an area which can not be directly observed by eyes of the user, and can be administered only through own experience and manual fumbling, such as back, buttocks, rear neck, armpit, rear inner side of legs and the like, when the user performs drug administration through a microneedle patch on the area, the user needs to firstly determine the area through hands, then performs drug administration through the other hand-held device, and if the drug administration area is sterilized through a sterilizing solvent such as alcohol and the like, the drug administration area is easy to pollute, or the drug administration area is a wound surface, and if the direction is confirmed through hands, the phenomena of infection and pollution can be caused; in addition, if the microneedle is directly administered through the device without first positioning by the hand of the user, it may occur that the wrong or deviated administration area is administered, which may cause a mistake in the administration area, affect the efficacy and efficacy, and may cause waste if the administration is performed in a non-administration area.
Therefore, in the present embodiment, the above-described problems are solved by a soluble microneedle delivery device provided by the present embodiment. The device comprises a first laser ranging unit 131, a second laser ranging unit 132 and a laser positioner 133; the first laser ranging unit 131, the second laser ranging unit 132 and the laser positioner 133 are electrically connected to the process. When the device is used, a user holds the device and moves to the vicinity of a drug administration area, the device is positioned through the laser positioner 133, when the device moves to the upper side of the drug administration area, the laser positioner 133 obtains the current coordinates to obtain positioning coordinate points, the first laser ranging unit 131 and the second laser ranging unit 132 respectively obtain the boundary distances between the current positioning coordinate points and the edges of the preset drug administration area, the data can be further transmitted to the mobile intelligent communication equipment through a visual screen or a network, or voice prompt is carried out, so that the user is prompted whether the area is the correct drug administration area or not, whether the deviation value is enough, or the direction of the device is required to be moved by the user, and therefore the accuracy of the user in drug administration of the body part which cannot be observed through holding the device is greatly improved, and convenience is provided for the user in drug administration.
Preferably, the soluble microneedle patch delivery device 1 further comprises an audio cue 14;
the audio prompter 14 is arranged in the main body assembly 11; the audio prompter 14 is electrically connected with the processor 112;
the audio prompter 14 is used for giving a voice prompt to the distance and the position of the microneedle patch from a drug administration area based on the positioning instruction of the processor 112; and prompting the pressure degree of the administration area according to the administration pressure value.
The audio prompter 14 can give corresponding prompts according to different conditions, so that the user can adjust parameters such as strength, position and the like according to the prompt tone.
Furthermore, in the present embodiment, the soluble microneedle patch delivery device may further include an image recognition component and a network component. Wherein the image recognition assembly includes a microneedle drug delivery assembly 12 positioned on a side facing the skin of the user. The image recognition component comprises an image acquisition unit and a data storage unit; the image acquisition unit can be a camera, a camera and the like and is used for acquiring images of the skin of a user; the data storage unit stores an image recognition program, communicates with the cloud or the server through the network component, and rapidly recognizes the acquired image, so as to judge whether the area is a preset administration area, if the area is the preset administration area, the audio prompt is performed through the audio prompt device 14, and if the area does not belong to the administration area, the error position is prompted. In the image recognition process, the characteristic extraction can be firstly carried out on the acquired image through the neural network learning technology, the minimum screenshot of the characteristic is intercepted, and the neural network learning training is carried out on the minimum screenshot, so that whether the region is a preset administration region or not is recognized. The image recognition technology improves the accuracy of the selection of the drug delivery positions, and provides convenience for accurate drug delivery of partial crowds in partial occasions.
Example 5:
referring to fig. 6 to 7, based on the above-described embodiment 2, the present embodiment provides a soluble microneedle patch delivery device 1, wherein the soluble microneedle patch delivery device 1 further includes at least two fixing strap portions 15 connected with the main body assembly 11;
the fixing strap portion 15 includes a strap body 151 connected to the main body assembly 11, and a fixing connector 152 provided at one end of the strap body 151 different from the main body assembly 11;
in use, the binding band body 151 of the fixing band portion 15 is tightened and connected and fixed by the fixing connector 152, so that the microneedle drug introducing assembly 12 connected to the main body assembly 11 is fixed to the administration area.
The number of the fixing band portions 15 may be plural, and in this embodiment, 4 are preferable, and two are set on the left and right sides of the main body assembly 11. Each of the fixed strap portions 15 includes a strap body 151 connected to the main body assembly 11, and a fixed connector 152 disposed away from the main body assembly 11. The fixed connection 152 may be fixedly connected by various means, such as adhesive, clamping, etc. It may be snap-in, hook-and-loop, etc.
The position where the fixing strap portion 15 is disposed may be set according to the actual requirement of the patient, for example, for the administration of the knee, the fixing strap portion 15 is required to be a crossed fixing strap to achieve binding, so as to improve stability; if the administration is to the abdominal region, the fixing band portions 15 on both sides may be fixing bands arranged in parallel.
From the outside, can be through fixed band connection two soluble microneedle dosing device, realize the dosing to the eye, for example: on the basis of the embodiment 2, a soluble microneedle administration system is provided, comprising two soluble microneedle administration devices connected for acting on eyes of a user, respectively;
the two soluble microneedle drug delivery devices are also provided with head fixing belts connected with the two soluble microneedle drug delivery devices and are used for being placed at the hindbrain position to realize fixation.
In this embodiment, the device is provided mainly facing the area to be administered, or the area to be administered for a long time, and the fixation by the band is required, for example, the abdomen area, the trunk area of the limbs, etc., and the special administration mode for the specific area is realized by the fixation band portion 15 connected with the main body assembly 11, thereby providing convenience for the user to administer the drug.
In addition, the invention also provides a use method of the soluble microneedle drug delivery device, which comprises the following steps:
1. a pressure sensing layer 1221 of the microneedle drug delivery pressure sensing portion 122 that places a dissolvable microneedle patch in the microneedle drug delivery assembly 12 of the drug delivery device;
2. the hand-held medicine feeding device aims the micro-object on the pressure sensing layer 1221 at the corresponding medicine feeding area on the skin, presses the micro-object with force, and reminds a user through flashing of a blue lamp after the pressing force reaches a specified value;
3. the switch of the microneedle administration accelerating dissolution portion 121 is activated, and the microneedle administration accelerating dissolution portion 121 starts to operate.
4. The soluble microneedle delivery device is removed and the soluble microneedle substrate patch attached to the pressure sensitive layer 1221 is removed and discarded.
Claims (6)
1. A dissolvable microneedle patch delivery device, comprising:
a body assembly, a microneedle drug introduction assembly coupled to the body assembly; wherein,
the microneedle drug introduction assembly comprises a microneedle drug administration accelerating dissolution part and/or a microneedle drug administration pressure sensing part;
one end of the microneedle administration accelerating dissolution part is connected with the main body component, and the other end is connected with the microneedle administration pressure sensing part;
the microneedle drug delivery pressure sensing part comprises a pressure sensing layer and a pressure sensor connected with the pressure sensing layer;
The microneedle drug delivery pressure sensing part is used for placing a microneedle patch on the pressure sensing layer so as to facilitate drug delivery to a drug delivery area through the microneedle patch and obtain a drug delivery pressure value through the pressure sensor;
the main body assembly comprises a main body shell, and a processor and a power supply assembly which are arranged in the main body shell;
the power supply assembly is used for supplying power to the soluble microneedle patch drug delivery device;
the processor is used for processing data of the soluble microneedle patch administration device in the administration process;
the processor is electrically connected with the pressure sensor;
the main body assembly further comprises a pressure indicator lamp, a controller and a display screen which are arranged on the main body shell;
the pressure indicator lamp, the controller and the display screen are electrically connected with the processor;
the pressure indicator lamp is used for feeding back according to the pressure data acquired by the pressure sensor;
the controller is used for setting parameters and controlling a switch of the soluble microneedle patch administration device;
the display screen is used for displaying pressure data of the microneedle administration pressure sensing part;
the microneedle administration accelerating dissolution part comprises one or more of a heating unit, an ultrasonic vibration unit and a micro-current control unit;
The soluble microneedle patch drug delivery device also comprises a laser positioning device;
the laser positioning device comprises a first laser ranging unit, a second laser ranging unit and a laser positioner; the first laser ranging unit, the second laser ranging unit and the laser positioner are electrically connected with the processor;
the laser positioning device is arranged on the microneedle drug introduction assembly and is arranged at one end of the microneedle drug introduction assembly, which is away from the main body assembly; the first laser ranging unit, the second laser ranging unit and the laser positioner are arranged on the microneedle medicament introducing assembly in a triangular shape;
the first laser ranging unit and the second laser ranging unit are used for respectively acquiring the boundary distance and the vertical distance of the microneedle drug introduction assembly in the drug administration area;
the laser locator is used for locating the administration area according to the locating instruction of the processor;
when the device is used, the soluble microneedle patch drug delivery device is used for positioning the drug delivery area through the laser positioner, obtaining coordinate points in the drug delivery area as positioning coordinate points, and obtaining the boundary distance of the drug delivery area taking the positioning coordinate points as the center and the vertical distance from the drug delivery area through the first laser ranging unit and the second laser ranging unit based on the positioning coordinate points.
2. The soluble microneedle patch delivery device of claim 1,
the heating unit comprises a heating plate, a temperature sensor and a heating control circuit;
the heating plate is electrically connected with the heating control circuit;
the temperature sensor is electrically connected with the heating control circuit and the processor.
3. The soluble microneedle patch delivery device of claim 1,
the ultrasonic vibration unit comprises a transducer, an ultrasonic generation module and a bridge type amplifying circuit;
the ultrasonic generating module transmits the vibration signal generated by the ultrasonic generating module to the bridge type amplifying circuit; and, the bridge amplifying circuit outputs the corresponding pulse and loads the pulse to the transducer so as to generate ultrasonic vibration.
4. The soluble microneedle patch delivery device of claim 1,
the micro-current control unit comprises a micro-current converter, a micro-current stimulation generator and a micro-current conducting contact, wherein the micro-current stimulation generator is electrically connected with the micro-current converter;
the micro-current converter is electrically connected with the processor; the micro-current conducting contact is electrically connected with the micro-current stimulation generator and is connected with the microneedle administration pressure sensing part;
The micro-current converter receives a micro-current control instruction of the processor; and, based on the microcurrent control instructions, the microcurrent stimulation generator generates microcurrent stimulation signals and conducts through the microcurrent conduction contacts.
5. The dissolvable microneedle patch delivery device of claim 1, further comprising an audio cue;
the audio prompter is arranged in the main body component; the audio prompter is electrically connected with the processor;
the audio prompter is used for giving a voice prompt for the distance and the direction between the microneedle patch and the administration area based on the positioning instruction of the processor; and prompting the pressure degree of the administration area according to the administration pressure value.
6. The dissolvable microneedle patch delivery device of any one of claims 2-4, further comprising at least two fixation strap portions connected to the body assembly;
the fixing strap part comprises a strap body connected with the main body component and a fixing connecting piece arranged at one end of the strap body, which is different from the main body component;
When the microneedle drug delivery device is used, the binding band body of the fixing binding band part is used for binding, and the fixing connection piece is used for connecting and fixing, so that the microneedle drug delivery device connected with the main body assembly is conveniently fixed in the drug delivery area.
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| CN109432585B (en) * | 2018-11-08 | 2021-08-17 | 中科微针（北京）科技有限公司 | Microneedle device for percutaneous administration |
| CN110613892A (en) * | 2019-07-10 | 2019-12-27 | 厦门大学 | Transdermal drug delivery system |
| CN111956948A (en) * | 2020-01-16 | 2020-11-20 | 广州医科大学 | Wearable remote control thermal response microneedle array patch and preparation method thereof |
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